melatonin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1672 73-31-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • melatonin
  • melatol
  • melatonine
  • circadin
A biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective antioxidant.
  • Molecular weight: 232.28
  • Formula: C13H16N2O2
  • CLOGP: 1.03
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 54.12
  • ALOGS: -3.21
  • ROTB: 4

Drug dosage:

DoseUnitRoute
2 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1.16 mg/mL Bocci G, Oprea TI, Benet LZ
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.36 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 12 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.10 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 16.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.39 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.10 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
March 25, 2020 PMDA Nobelpharma Co., Ltd
None FDA
June 29, 2007 EMA RAD NEURIM PHARMACEUTICALS EEC SARL

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Intentional self-injury 549.13 10.45 302 47334 25385 63416001
Intentional overdose 420.41 10.45 387 47249 73765 63367621
Pneumonia aspiration 241.09 10.45 203 47433 34337 63407049
Somnolence 206.13 10.45 430 47206 178255 63263131
Coma 168.32 10.45 224 47412 64140 63377246
Gastrooesophageal reflux disease 152.05 10.45 264 47372 95375 63346011
Contraindicated product administered 141.14 10.45 5 47631 217643 63223743
Pemphigus 123.56 10.45 3 47633 183723 63257663
Synovitis 104.02 10.45 10 47626 186908 63254478
Hand deformity 98.90 10.45 5 47631 159452 63281934
Glossodynia 98.41 10.45 10 47626 178866 63262520
Desmoplastic small round cell tumour 98.26 10.45 21 47615 75 63441311
Maternal exposure during pregnancy 96.99 10.45 23 47613 220039 63221347
Systemic lupus erythematosus 93.73 10.45 21 47615 208897 63232489
Treatment failure 87.32 10.45 21 47615 199022 63242364
Arthropathy 80.08 10.45 38 47598 234754 63206632
Joint swelling 76.32 10.45 80 47556 327586 63113800
Wound 72.04 10.45 17 47619 163246 63278140
Insomnia 71.97 10.45 336 47300 214916 63226470
Drug ineffective 68.45 10.45 482 47154 1044283 62397103
Discomfort 63.65 10.45 23 47613 167351 63274035
Drug intolerance 61.62 10.45 85 47551 308576 63132810
Exposure during pregnancy 59.79 10.45 21 47615 155526 63285860
Swelling 57.86 10.45 73 47563 275305 63166081
General physical health deterioration 52.94 10.45 44 47592 201358 63240028
Therapeutic product effect decreased 49.81 10.45 43 47593 193144 63248242
Helicobacter infection 48.95 10.45 6 47630 92779 63348607
Cestode infection 48.87 10.45 15 47621 272 63441114
Rheumatoid arthritis 47.59 10.45 73 47563 253746 63187640
Aplastic anaemia 46.64 10.45 46 47590 9523 63431863
Seizure 44.98 10.45 208 47428 132426 63308960
Suicidal ideation 43.63 10.45 124 47512 62297 63379089
Feeling abnormal 41.29 10.45 220 47416 148172 63293214
Alopecia 39.46 10.45 126 47510 337410 63103976
Drug hypersensitivity 39.17 10.45 112 47524 310575 63130811
Hepatic enzyme increased 39.07 10.45 57 47579 202271 63239115
Premenstrual syndrome 38.78 10.45 16 47620 703 63440683
Disturbance in attention 38.32 10.45 87 47549 38102 63403284
Muscle injury 37.67 10.45 3 47633 65342 63376044
Metastases to peritoneum 36.63 10.45 26 47610 3416 63437970
Abdominal discomfort 35.98 10.45 122 47514 320763 63120623
Infusion related reaction 35.15 10.45 83 47553 245438 63195948
Constipation 34.83 10.45 288 47348 224655 63216731
Tachycardia 34.81 10.45 178 47458 117978 63323408
Magnesium deficiency 34.75 10.45 14 47622 578 63440808
Lip pruritus 34.54 10.45 16 47620 931 63440455
Onychoclasis 34.27 10.45 32 47604 6190 63435196
Fatigue 34.18 10.45 889 46747 887139 62554247
Anxiety 33.94 10.45 279 47357 217262 63224124
Clostridium test positive 33.65 10.45 24 47612 3177 63438209
Hallucination 33.65 10.45 104 47532 54713 63386673
Suicide attempt 33.24 10.45 111 47525 60807 63380579
Irritability 32.68 10.45 73 47563 31621 63409765
Lichen sclerosus 32.14 10.45 16 47620 1093 63440293
Tremor 30.82 10.45 187 47449 132052 63309334
Polymenorrhoea 30.68 10.45 16 47620 1205 63440181
Menstruation delayed 30.64 10.45 18 47618 1711 63439675
COVID-19 29.64 10.45 165 47471 112938 63328448
Restless legs syndrome 29.20 10.45 51 47585 18480 63422906
Epilepsy with myoclonic-atonic seizures 28.46 10.45 8 47628 105 63441281
Derailment 27.82 10.45 7 47629 58 63441328
Akathisia 27.28 10.45 34 47602 9112 63432274
Choanal stenosis 26.97 10.45 6 47630 27 63441359
Product dose omission issue 26.70 10.45 281 47355 234032 63207354
Depression 26.46 10.45 244 47392 196248 63245138
Poisoning deliberate 26.21 10.45 37 47599 11181 63430205
Hypersensitivity 25.99 10.45 122 47514 292563 63148823
Infusion site pruritus 25.74 10.45 27 47609 6008 63435378
Electrocardiogram PR prolongation 25.69 10.45 12 47624 712 63440674
Illness 25.54 10.45 88 47548 48971 63392415
Tic 24.79 10.45 15 47621 1505 63439881
Agitation 24.29 10.45 99 47537 59658 63381728
Irritable bowel syndrome 24.23 10.45 16 47620 82396 63358990
Vision blurred 24.01 10.45 134 47502 91790 63349596
Impaired healing 23.86 10.45 25 47611 102517 63338869
Body temperature fluctuation 23.72 10.45 17 47619 2268 63439118
Abnormal dreams 23.56 10.45 34 47602 10482 63430904
Liver injury 23.53 10.45 8 47628 60512 63380874
Staphylococcal scalded skin syndrome 22.96 10.45 7 47629 124 63441262
Metastases to lymph nodes 22.24 10.45 29 47607 8129 63433257
Rheumatic fever 22.22 10.45 3 47633 43108 63398278
Restlessness 22.04 10.45 60 47576 29393 63411993
Angiokeratoma 22.03 10.45 7 47629 143 63441243
Change in seizure presentation 21.42 10.45 9 47627 414 63440972
Infection 21.25 10.45 94 47542 229079 63212307
Lower respiratory tract infection 21.18 10.45 42 47594 132265 63309121
Arthralgia 21.05 10.45 301 47335 569409 62871977
Infusion site pain 21.04 10.45 42 47594 16827 63424559
Acute respiratory failure 20.76 10.45 65 47571 34420 63406966
Type 2 diabetes mellitus 20.75 10.45 11 47625 63857 63377529
Helplessness 20.69 10.45 8 47628 296 63441090
False positive investigation result 20.65 10.45 10 47626 643 63440743
Neuralgia 20.60 10.45 54 47582 25872 63415514
Tri-iodothyronine free decreased 20.19 10.45 8 47628 316 63441070
Creatinine urine decreased 20.05 10.45 7 47629 193 63441193
Rabbit syndrome 20.00 10.45 8 47628 324 63441062
Rhabdomyolysis 19.62 10.45 75 47561 43876 63397510
Anticonvulsant drug level decreased 19.51 10.45 12 47624 1240 63440146
Sleep apnoea syndrome 19.50 10.45 57 47579 29076 63412310
Attention deficit hyperactivity disorder 19.26 10.45 17 47619 3059 63438327
Respiratory syncytial virus infection 19.21 10.45 25 47611 6993 63434393
Fall 19.04 10.45 406 47230 391928 63049458
Cognitive disorder 18.51 10.45 87 47549 55728 63385658
Abnormal behaviour 18.45 10.45 46 47590 21380 63420006
Aorta hypoplasia 18.01 10.45 6 47630 143 63441243
Pulmonary fibrosis 17.83 10.45 4 47632 39805 63401581
Underdose 17.70 10.45 53 47583 27403 63413983
Urine leukocyte esterase positive 17.06 10.45 17 47619 3562 63437824
C-reactive protein increased 17.00 10.45 28 47608 94679 63346707
Interstitial lung disease 16.91 10.45 13 47623 61895 63379491
Parasitic gastroenteritis 16.88 10.45 4 47632 25 63441361
Multiple organ dysfunction syndrome 16.70 10.45 11 47625 56741 63384645
Anticholinergic syndrome 16.61 10.45 14 47622 2368 63439018
Infusion site rash 16.61 10.45 13 47623 1981 63439405
Orgasmic sensation decreased 16.51 10.45 3 47633 3 63441383
Defiant behaviour 16.51 10.45 3 47633 3 63441383
Infusion site scar 16.50 10.45 8 47628 516 63440870
Mental status changes 16.40 10.45 66 47570 39533 63401853
Psychomotor hyperactivity 16.35 10.45 29 47607 10634 63430752
Convulsive threshold lowered 16.21 10.45 7 47629 345 63441041
Small intestine ulcer 16.11 10.45 7 47629 350 63441036
Hepatic function abnormal 16.11 10.45 4 47632 37138 63404248
Protrusion tongue 15.87 10.45 7 47629 363 63441023
Neutrophil count increased 15.86 10.45 37 47599 16490 63424896
Nephritis allergic 15.65 10.45 6 47630 217 63441169
Tumour marker abnormal 15.57 10.45 7 47629 380 63441006
Psoriatic arthropathy 15.57 10.45 28 47608 91492 63349894
Sinus bradycardia 15.55 10.45 34 47602 14517 63426869
Coagulation factor V level increased 15.30 10.45 3 47633 6 63441380
Immunodeficiency common variable 15.17 10.45 6 47630 236 63441150
Red blood cell sedimentation rate increased 15.15 10.45 7 47629 43975 63397411
Myocardial infarction 14.90 10.45 33 47603 99860 63341526
Pre-existing condition improved 14.73 10.45 24 47612 8220 63433166
Stupor 14.56 10.45 17 47619 4258 63437128
Muscle spasms 14.50 10.45 180 47456 155970 63285416
Basophil count increased 14.48 10.45 9 47627 948 63440438
Peripheral swelling 14.32 10.45 129 47507 265813 63175573
Vascular stent thrombosis 14.30 10.45 9 47627 968 63440418
Nightmare 14.26 10.45 39 47597 19155 63422231
Infusion site swelling 14.25 10.45 26 47610 9744 63431642
Medication error 14.25 10.45 11 47625 52273 63389113
Therapy non-responder 14.04 10.45 22 47614 75879 63365507
Depressed level of consciousness 13.95 10.45 87 47549 61991 63379395
Headache 13.92 10.45 594 47042 632647 62808739
Ascites 13.88 10.45 64 47572 40664 63400722
Product confusion 13.77 10.45 3 47633 12 63441374
Hypersomnia 13.73 10.45 37 47599 18018 63423368
Metapneumovirus infection 13.63 10.45 9 47627 1051 63440335
Sinus disorder 13.62 10.45 45 47591 24508 63416878
Diarrhoea 13.55 10.45 661 46975 714705 62726681
Balance disorder 13.53 10.45 109 47527 84313 63357073
Blood viscosity abnormal 13.36 10.45 5 47631 169 63441217
Infusion site warmth 13.33 10.45 11 47625 1807 63439579
Inflammation 13.26 10.45 26 47610 82247 63359139
Urinary tract infection 13.17 10.45 275 47361 264409 63176977
Snoring 13.14 10.45 16 47620 4186 63437200
Lethargy 12.91 10.45 79 47557 55928 63385458
Parainfluenzae virus infection 12.88 10.45 12 47624 2315 63439071
Skin burning sensation 12.76 10.45 29 47607 12705 63428681
Tracheo-oesophageal fistula 12.75 10.45 7 47629 585 63440801
Band sensation 12.68 10.45 8 47628 865 63440521
Thyroid cyst 12.58 10.45 7 47629 600 63440786
Pregnancy 12.48 10.45 6 47630 36830 63404556
Memory impairment 12.31 10.45 126 47510 104132 63337254
Renal failure 12.31 10.45 46 47590 117606 63323780
Infective pulmonary exacerbation of cystic fibrosis 12.28 10.45 23 47613 8794 63432592
Mobility decreased 12.27 10.45 48 47588 121111 63320275
Gingival pain 12.26 10.45 22 47614 8140 63433246
Activation syndrome 12.18 10.45 5 47631 217 63441169
Unresponsive to stimuli 12.17 10.45 54 47582 33762 63407624
Urine ketone body present 12.14 10.45 12 47624 2491 63438895
Lactose intolerance 12.13 10.45 13 47623 2965 63438421
Hospitalisation 12.12 10.45 107 47529 84974 63356412
Gastrointestinal disorder 12.05 10.45 54 47582 131185 63310201
Oral cavity fistula 11.94 10.45 7 47629 663 63440723
Epilepsy 11.93 10.45 46 47590 27019 63414367
Water intoxication 11.90 10.45 6 47630 421 63440965
Therapeutic response unexpected 11.89 10.45 36 47600 18723 63422663
Premature delivery 11.78 10.45 4 47632 30277 63411109
Oculogyric crisis 11.76 10.45 10 47626 1711 63439675
Alcoholic pancreatitis 11.60 10.45 3 47633 28 63441358
Meningitis aseptic 11.40 10.45 16 47620 4807 63436579
Crying 11.39 10.45 41 47595 23302 63418084
Hallucination, visual 11.27 10.45 36 47600 19262 63422124
Gaze palsy 11.27 10.45 9 47627 1411 63439975
Aggression 11.24 10.45 41 47595 23457 63417929
On and off phenomenon 11.21 10.45 10 47626 1825 63439561
Infusion site discomfort 11.13 10.45 9 47627 1437 63439949
Mood altered 11.00 10.45 30 47606 14713 63426673
Hyporesponsive to stimuli 10.97 10.45 8 47628 1096 63440290
Postoperative ileus 10.90 10.45 6 47630 504 63440882
Complement factor C4 decreased 10.89 10.45 5 47631 285 63441101
Complement factor C3 decreased 10.76 10.45 5 47631 293 63441093
Infusion site extravasation 10.73 10.45 24 47612 10402 63430984
Dermatitis atopic 10.71 10.45 23 47613 9701 63431685
Rash 10.68 10.45 330 47306 560541 62880845
Hip arthroplasty 10.66 10.45 12 47624 47634 63393752
Nasal congestion 10.64 10.45 85 47551 65575 63375811
Orbital oedema 10.59 10.45 5 47631 304 63441082
Product use issue 10.58 10.45 110 47526 220410 63220976
Cytokine release syndrome 10.55 10.45 29 47607 14285 63427101
Weight decreased 10.51 10.45 277 47359 276521 63164865

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Appendicolith 294.47 11.61 149 32500 8452 34915830
Appendicitis 243.45 11.61 159 32490 14648 34909634
Stress 170.42 11.61 174 32475 30173 34894109
Cardiogenic shock 164.91 11.61 161 32488 26457 34897825
Intentional self-injury 145.58 11.61 113 32536 13658 34910624
Abdominal distension 131.85 11.61 213 32436 58279 34866003
Congenital hiatus hernia 121.82 11.61 41 32608 803 34923479
Ventricular fibrillation 115.23 11.61 124 32525 22830 34901452
Blood phosphorus increased 115.01 11.61 78 32571 7643 34916639
Multiple organ dysfunction syndrome 100.21 11.61 221 32428 76345 34847937
Constipation 96.40 11.61 314 32335 136668 34787614
Ascites 92.10 11.61 160 32489 46411 34877871
Victim of child abuse 84.40 11.61 32 32617 895 34923387
Somnolence 81.10 11.61 258 32391 110858 34813424
Hyponatraemia 78.57 11.61 211 32438 82480 34841802
Epidural lipomatosis 66.74 11.61 28 32621 1026 34923256
Hallucination 61.05 11.61 143 32506 51355 34872927
Agitation 59.12 11.61 151 32498 57248 34867034
Malignant melanoma in situ 56.40 11.61 29 32620 1699 34922583
Parasomnia 55.85 11.61 19 32630 385 34923897
Respiratory depression 53.79 11.61 71 32578 16174 34908108
Breath sounds abnormal 52.97 11.61 47 32602 6834 34917448
Myasthenia gravis 52.62 11.61 47 32602 6893 34917389
Intentional overdose 52.55 11.61 122 32527 43552 34880730
Juvenile idiopathic arthritis 51.07 11.61 28 32621 1869 34922413
Aplastic anaemia 49.64 11.61 53 32596 9663 34914619
Dry mouth 47.50 11.61 94 32555 30071 34894211
Aggression 44.87 11.61 107 32542 38857 34885425
General physical health deterioration 42.66 11.61 234 32415 128035 34796247
Product prescribing error 41.73 11.61 76 32573 22851 34901431
Bronchiectasis 40.71 11.61 48 32601 9753 34914529
Product administered to patient of inappropriate age 39.17 11.61 29 32620 3262 34921020
Insomnia 36.88 11.61 193 32456 103714 34820568
Vomiting 36.87 11.61 373 32276 247248 34677034
Drug dependence 36.37 11.61 74 32575 24143 34900139
Oculogyric crisis 36.17 11.61 21 32628 1565 34922717
Sepsis 35.19 11.61 271 32378 166290 34757992
Choreoathetosis 35.14 11.61 18 32631 1046 34923236
Fall 33.81 11.61 313 32336 202572 34721710
Dystonia 33.76 11.61 46 32603 10799 34913483
Blood uric acid increased 33.31 11.61 43 32606 9581 34914701
Interstitial lung disease 32.93 11.61 10 32639 65272 34859010
Abdominal pain 31.17 11.61 260 32389 163358 34760924
Abnormal sleep-related event 31.04 11.61 13 32636 474 34923808
Child abuse 29.25 11.61 12 32637 415 34923867
Myocardial infarction 28.59 11.61 43 32606 121042 34803240
Drug therapy 28.41 11.61 16 32633 1125 34923157
Hyperphosphataemia 27.75 11.61 27 32622 4410 34919872
Analgesic therapy 27.61 11.61 15 32634 983 34923299
Electrocardiogram QT interval abnormal 27.31 11.61 8 32641 97 34924185
Blood cholesterol increased 26.49 11.61 59 32590 20484 34903798
Extrapyramidal disorder 26.41 11.61 45 32604 12835 34911447
Dyskinesia 26.28 11.61 62 32587 22351 34901931
Joint injury 25.71 11.61 37 32612 9136 34915146
Full blood count abnormal 25.64 11.61 55 32594 18613 34905669
Micturition urgency 25.53 11.61 31 32618 6494 34917788
Dopamine dysregulation syndrome 25.19 11.61 11 32638 445 34923837
Dissociative disorder 24.90 11.61 11 32638 458 34923824
Suicidal behaviour 24.40 11.61 16 32633 1481 34922801
Psychomotor hyperactivity 24.36 11.61 37 32612 9585 34914697
Suicidal ideation 24.31 11.61 88 32561 40300 34883982
Hepatic function abnormal 23.86 11.61 6 32643 44357 34879925
Benign prostatic hyperplasia 23.82 11.61 46 32603 14449 34909833
Hypercholesterolaemia 22.62 11.61 34 32615 8728 34915554
Paradoxical drug reaction 22.11 11.61 21 32628 3330 34920952
Abnormal behaviour 21.97 11.61 62 32587 24907 34899375
Drooling 21.95 11.61 21 32628 3361 34920921
Renal impairment 21.88 11.61 34 32615 94479 34829803
Salivary hypersecretion 21.55 11.61 33 32616 8611 34915671
Confusional state 21.32 11.61 217 32432 143943 34780339
Acute myocardial infarction 21.03 11.61 12 32637 53707 34870575
Off label use 20.71 11.61 525 32124 418999 34505283
Incorrect route of product administration 20.69 11.61 44 32605 14801 34909481
Toxicity to various agents 20.42 11.61 107 32542 200255 34724027
Renal failure 20.17 11.61 59 32590 130498 34793784
Hallucinations, mixed 19.97 11.61 18 32631 2671 34921611
Intentional product misuse 19.95 11.61 90 32559 45521 34878761
Poor quality sleep 19.85 11.61 31 32618 8225 34916057
Mixed dementia 19.68 11.61 8 32641 270 34924012
Hospice care 19.46 11.61 28 32621 6912 34917370
Acute kidney injury 19.30 11.61 187 32462 304801 34619481
Cardiac failure 19.12 11.61 35 32614 91213 34833069
Seizure 19.08 11.61 165 32484 104692 34819590
Obesity 18.92 11.61 39 32610 12839 34911443
Ear infection 18.72 11.61 34 32615 10197 34914085
Tardive dyskinesia 18.69 11.61 25 32624 5765 34918517
Iron deficiency 18.56 11.61 24 32625 5357 34918925
Hypogonadism 18.55 11.61 16 32633 2239 34922043
Gastric hypomotility 18.35 11.61 6 32643 107 34924175
Nausea 18.13 11.61 430 32219 339478 34584804
Anaemia 17.91 11.61 136 32513 233199 34691083
Tri-iodothyronine decreased 17.71 11.61 6 32643 120 34924162
Illness 17.60 11.61 39 32610 13490 34910792
Stoma site discharge 17.46 11.61 12 32637 1201 34923081
Bladder dilatation 17.43 11.61 13 32636 1479 34922803
Chronic obstructive pulmonary disease 17.42 11.61 91 32558 48827 34875455
Subacute cutaneous lupus erythematosus 17.04 11.61 11 32638 991 34923291
Non-high-density lipoprotein cholesterol increased 17.01 11.61 6 32643 136 34924146
Cardio-respiratory arrest 16.90 11.61 16 32633 55257 34869025
Muscle rigidity 16.82 11.61 33 32616 10485 34913797
Delirium 16.48 11.61 83 32566 43908 34880374
Hallucination, visual 16.46 11.61 45 32604 17746 34906536
Device kink 16.34 11.61 8 32641 422 34923860
Serotonin syndrome 16.09 11.61 48 32601 19885 34904397
Device issue 16.03 11.61 31 32618 9746 34914536
Disease risk factor 15.85 11.61 3 32646 3 34924279
Multiple drug therapy 15.81 11.61 8 32641 453 34923829
Mental status changes 15.80 11.61 74 32575 38009 34886273
Opisthotonus 15.71 11.61 8 32641 459 34923823
Gallbladder enlargement 15.68 11.61 11 32638 1137 34923145
Tremor 15.56 11.61 131 32518 82456 34841826
Viral diarrhoea 15.55 11.61 6 32643 176 34924106
Pleurothotonus 15.20 11.61 11 32638 1194 34923088
Shunt malfunction 15.18 11.61 6 32643 188 34924094
Embedded device 15.15 11.61 7 32642 324 34923958
Thrombocytopenia 15.05 11.61 85 32564 156162 34768120
Clostridium test positive 14.94 11.61 17 32632 3325 34920957
Restlessness 14.89 11.61 55 32594 25427 34898855
Thyroxine decreased 14.48 11.61 6 32643 213 34924069
Blood bilirubin increased 14.36 11.61 9 32640 38287 34885995
Sleep disorder 14.21 11.61 63 32586 31625 34892657
Abscess intestinal 14.20 11.61 12 32637 1634 34922648
Hypersomnia 14.19 11.61 34 32615 12373 34911909
Hyperkalaemia 14.19 11.61 27 32622 69362 34854920
Leukopenia 14.17 11.61 23 32626 62833 34861449
Dissociation 14.12 11.61 12 32637 1646 34922636
Stoma site infection 14.04 11.61 9 32640 801 34923481
Malaise 13.92 11.61 109 32540 185716 34738566
Respiratory alkalosis 13.81 11.61 12 32637 1697 34922585
Neuralgia 13.76 11.61 38 32611 15075 34909207
Progesterone increased 13.54 11.61 3 32646 10 34924272
Parkinsonian rest tremor 13.49 11.61 5 32644 131 34924151
Hepatitis 13.31 11.61 3 32646 23901 34900381
Transient ischaemic attack 13.23 11.61 56 32593 27557 34896725
Glycogen storage disease type VIII 13.11 11.61 3 32646 12 34924270
Product dose omission issue 13.09 11.61 170 32479 119541 34804741
False positive investigation result 13.04 11.61 7 32642 448 34923834
Speech disorder 13.01 11.61 53 32596 25633 34898649
Rheumatoid arthritis 12.99 11.61 10 32639 38228 34886054
Growth hormone-producing pituitary tumour 12.94 11.61 4 32645 59 34924223
Respiratory arrest 12.92 11.61 5 32644 28038 34896244
Intentional dose omission 12.68 11.61 16 32633 3484 34920798
Disease progression 12.58 11.61 55 32594 108022 34816260
Cyanosis 12.53 11.61 33 32616 12731 34911551
Camptocormia 12.49 11.61 5 32644 162 34924120
Hyperchloraemia 12.34 11.61 7 32642 499 34923783
Acanthosis nigricans 12.10 11.61 5 32644 176 34924106
Eye movement disorder 12.09 11.61 17 32632 4110 34920172
Arrhythmia supraventricular 12.04 11.61 10 32639 1330 34922952
Dementia 11.96 11.61 34 32615 13714 34910568
Dysarthria 11.90 11.61 64 32585 34718 34889564
Middle insomnia 11.68 11.61 22 32627 6780 34917502
Foetal exposure during pregnancy 11.68 11.61 11 32638 38090 34886192
Haematuria traumatic 11.65 11.61 5 32644 194 34924088
Hypernatraemia 11.64 11.61 25 32624 8465 34915817
Reduced facial expression 11.63 11.61 9 32640 1082 34923200

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Intentional self-injury 465.94 10.39 307 66337 32112 79645632
Appendicolith 307.83 10.39 148 66496 8403 79669341
Intentional overdose 278.92 10.39 391 66253 105569 79572175
Somnolence 240.23 10.39 581 66063 238400 79439344
Appendicitis 217.18 10.39 162 66482 20632 79657112
Pneumonia aspiration 127.84 10.39 213 66431 66754 79610990
Cardiogenic shock 127.43 10.39 166 66478 41748 79635996
Gastrooesophageal reflux disease 127.34 10.39 274 66370 103972 79573772
Congenital hiatus hernia 123.18 10.39 40 66604 784 79676960
Ascites 116.68 10.39 219 66425 75343 79602401
Stress 103.88 10.39 215 66429 79397 79598347
Aplastic anaemia 101.19 10.39 98 66546 17807 79659937
Constipation 100.96 10.39 486 66158 282564 79395180
Blood phosphorus increased 100.05 10.39 77 66567 10270 79667474
Ventricular fibrillation 97.91 10.39 127 66517 31799 79645945
Coma 93.84 10.39 238 66406 100411 79577333
Synovitis 93.33 10.39 9 66635 150725 79527019
Desmoplastic small round cell tumour 92.96 10.39 21 66623 90 79677654
Victim of child abuse 86.99 10.39 32 66612 921 79676823
Abdominal distension 84.83 10.39 256 66388 119394 79558350
Hallucination 76.04 10.39 199 66445 85546 79592198
Agitation 71.29 10.39 214 66430 99501 79578243
Pemphigus 70.30 10.39 3 66641 99579 79578165
Joint swelling 68.80 10.39 84 66560 288562 79389182
Treatment failure 67.41 10.39 29 66615 170457 79507287
Epidural lipomatosis 65.61 10.39 28 66616 1200 79676544
Contraindicated product administered 65.21 10.39 25 66619 157513 79520231
Pericarditis 65.11 10.39 6 66638 104230 79573514
Hand deformity 64.86 10.39 6 66638 103913 79573831
Maternal exposure during pregnancy 61.11 10.39 19 66625 136519 79541225
Multiple organ dysfunction syndrome 58.59 10.39 227 66417 120019 79557725
Insomnia 55.57 10.39 373 66271 244797 79432947
Systemic lupus erythematosus 53.97 10.39 17 66627 121132 79556612
Hyponatraemia 53.29 10.39 291 66353 177557 79500187
Wound 52.29 10.39 16 66628 116163 79561581
Aggression 52.23 10.39 125 66519 50833 79626911
Myasthenia gravis 51.53 10.39 53 66591 10346 79667398
Exposure during pregnancy 51.13 10.39 11 66633 101121 79576623
Arthropathy 50.72 10.39 44 66600 177067 79500677
Glossodynia 50.72 10.39 12 66632 103325 79574419
Suicidal ideation 50.06 10.39 159 66485 76181 79601563
Seizure 50.03 10.39 299 66345 188535 79489209
Malignant melanoma in situ 49.90 10.39 29 66615 2423 79675321
Parasomnia 48.13 10.39 18 66626 543 79677201
Cestode infection 47.75 10.39 15 66629 263 79677481
Clostridium test positive 47.57 10.39 41 66603 6413 79671331
Drug dependence 46.17 10.39 104 66540 40665 79637079
Interstitial lung disease 44.75 10.39 19 66625 112581 79565163
Hepatic function abnormal 43.61 10.39 5 66639 73102 79604642
Rheumatoid arthritis 41.40 10.39 69 66575 208401 79469343
Discomfort 41.36 10.39 27 66617 125590 79552154
Premenstrual syndrome 40.81 10.39 16 66628 550 79677194
Irritability 40.11 10.39 99 66545 41045 79636699
Respiratory depression 40.06 10.39 78 66566 27552 79650192
Drug ineffective 38.90 10.39 653 65991 1080260 78597484
Disturbance in attention 38.17 10.39 111 66533 50690 79627054
Tremor 35.69 10.39 254 66390 169829 79507915
Neuralgia 35.41 10.39 83 66561 33301 79644443
Akathisia 34.94 10.39 49 66595 13210 79664534
Fall 34.61 10.39 586 66058 487043 79190701
Juvenile idiopathic arthritis 34.58 10.39 30 66614 4733 79673011
Product administered to patient of inappropriate age 34.43 10.39 32 66612 5521 79672223
Mental status changes 33.91 10.39 128 66516 66831 79610913
Myocardial infarction 33.79 10.39 64 66580 184065 79493679
Lip pruritus 33.47 10.39 16 66628 896 79676848
Extrapyramidal disorder 32.85 10.39 64 66580 22615 79655129
Hypersensitivity 32.74 10.39 111 66533 262128 79415616
Helicobacter infection 32.46 10.39 9 66635 69695 79608049
Benign prostatic hyperplasia 32.22 10.39 44 66600 11568 79666176
Lichen sclerosus 32.16 10.39 16 66628 978 79676766
Polymenorrhoea 32.04 10.39 16 66628 986 79676758
Product prescribing error 31.84 10.39 96 66548 44717 79633027
Therapeutic product effect decreased 31.82 10.39 55 66589 163808 79513936
Dystonia 31.74 10.39 61 66583 21338 79656406
Sepsis 31.46 10.39 354 66290 269074 79408670
Drug hypersensitivity 31.21 10.39 136 66508 298780 79378964
Abnormal sleep-related event 30.82 10.39 15 66629 874 79676870
Child abuse 30.49 10.39 12 66632 417 79677327
False positive investigation result 30.47 10.39 16 66628 1096 79676648
Arthralgia 30.14 10.39 319 66325 571484 79106260
Alopecia 29.51 10.39 97 66547 231258 79446486
Magnesium deficiency 29.33 10.39 13 66631 611 79677133
Drug therapy 29.31 10.39 16 66628 1185 79676559
Analgesic therapy 29.02 10.39 15 66629 994 79676750
Blood uric acid increased 28.90 10.39 45 66599 13315 79664429
Anxiety 28.78 10.39 326 66318 248186 79429558
Metastases to peritoneum 28.68 10.39 26 66618 4346 79673398
Hypersomnia 28.52 10.39 61 66583 23025 79654719
Infusion related reaction 28.36 10.39 98 66546 230139 79447605
Choreoathetosis 27.86 10.39 17 66627 1553 79676191
Abnormal behaviour 27.76 10.39 80 66564 36341 79641403
Dry mouth 27.68 10.39 146 66498 87873 79589871
Paradoxical drug reaction 27.55 10.39 32 66612 7153 79670591
Epilepsy with myoclonic-atonic seizures 27.40 10.39 8 66636 108 79677636
Inflammation 27.18 10.39 23 66621 93730 79584014
Restlessness 27.05 10.39 93 66551 46399 79631345
Salivary hypersecretion 26.80 10.39 45 66599 14179 79663565
Breath sounds abnormal 26.76 10.39 48 66596 15936 79661808
Suicidal behaviour 26.76 10.39 22 66622 3225 79674519
Menstruation delayed 26.75 10.39 16 66628 1410 79676334
Product dose omission issue 26.12 10.39 319 66325 247218 79430526
Dissociative disorder 25.93 10.39 13 66631 808 79676936
Drug intolerance 25.88 10.39 123 66521 263996 79413748
Suicide attempt 25.70 10.39 137 66507 82795 79594949
Illness 25.30 10.39 91 66553 46420 79631324
Derailment 25.29 10.39 7 66637 77 79677667
Onychoclasis 25.09 10.39 27 66617 5551 79672193
Hepatic enzyme increased 24.38 10.39 75 66569 182535 79495209
Acute respiratory failure 23.94 10.39 106 66538 59435 79618309
Micturition urgency 23.83 10.39 40 66604 12601 79665143
Hyperphosphataemia 23.79 10.39 28 66616 6348 79671396
Renal failure 23.78 10.39 87 66557 200881 79476863
Psychomotor hyperactivity 23.74 10.39 47 66597 16802 79660942
Type 2 diabetes mellitus 23.73 10.39 9 66635 57113 79620631
Hypogonadism 23.66 10.39 16 66628 1744 79676000
Full blood count abnormal 23.58 10.39 81 66563 40393 79637351
Poisoning deliberate 23.55 10.39 50 66594 18778 79658966
Feeling abnormal 23.25 10.39 219 66425 158980 79518764
Dysarthria 23.24 10.39 115 66529 67507 79610237
Hallucination, visual 23.15 10.39 70 66574 32659 79645085
Abdominal pain 22.66 10.39 454 66190 389115 79288629
Impaired healing 22.49 10.39 24 66620 87631 79590113
Fatigue 22.49 10.39 970 65674 928757 78748987
Restless legs syndrome 22.46 10.39 51 66593 20041 79657703
Renal impairment 22.37 10.39 63 66581 157720 79520024
Tic 22.07 10.39 19 66625 2967 79674777
Rabbit syndrome 21.81 10.39 9 66635 354 79677390
Intentional product misuse 21.65 10.39 145 66499 95020 79582724
C-reactive protein increased 21.01 10.39 48 66596 128979 79548765
Tachycardia 20.93 10.39 234 66410 177534 79500210
Rash 20.83 10.39 349 66295 578009 79099735
Swelling 20.60 10.39 102 66542 216609 79461135
Angioedema 20.44 10.39 20 66624 76015 79601729
Psoriatic arthropathy 20.41 10.39 21 66623 77978 79599766
Anaphylactic reaction 20.32 10.39 24 66620 83719 79594025
Oculogyric crisis 20.24 10.39 18 66626 2934 79674810
Mixed dementia 20.19 10.39 8 66636 283 79677461
Bronchiectasis 19.88 10.39 52 66592 22334 79655410
COVID-19 19.69 10.39 210 66434 157464 79520280
Red blood cell sedimentation rate increased 19.49 10.39 7 66637 45935 79631809
Autism spectrum disorder 19.24 10.39 12 66632 1140 79676604
Cytomegalovirus infection 18.96 10.39 6 66638 42638 79635106
Crying 18.92 10.39 52 66592 22991 79654753
On and off phenomenon 18.81 10.39 18 66626 3222 79674522
Change in seizure presentation 18.68 10.39 9 66635 513 79677231
Cognitive disorder 18.67 10.39 111 66533 69815 79607929
Attention deficit hyperactivity disorder 18.49 10.39 18 66626 3291 79674453
Infusion site scar 18.48 10.39 8 66636 355 79677389
Helplessness 18.29 10.39 8 66636 364 79677380
Stoma site discharge 18.27 10.39 15 66629 2194 79675550
Angiokeratoma 18.15 10.39 7 66637 230 79677514
Tri-iodothyronine free decreased 18.13 10.39 8 66636 372 79677372
Influenza B virus test positive 18.09 10.39 8 66636 374 79677370
Anaphylactic shock 18.02 10.39 4 66640 35992 79641752
Anal incontinence 18.01 10.39 44 66600 18124 79659620
Vomiting 17.96 10.39 703 65941 665125 79012619
Behaviour disorder 17.64 10.39 24 66620 6289 79671455
Eye movement disorder 17.35 10.39 27 66617 7984 79669760
Lower respiratory tract infection 17.29 10.39 53 66591 129167 79548577
Hospice care 17.28 10.39 31 66613 10293 79667451
Serotonin syndrome 17.23 10.39 79 66565 44948 79632796
Antipsychotic drug level increased 17.18 10.39 23 66621 5934 79671810
Drug reaction with eosinophilia and systemic symptoms 17.15 10.39 17 66627 64227 79613517
Confusional state 16.97 10.39 366 66278 317631 79360113
Delirium 16.94 10.39 125 66519 84502 79593242
Infusion site pruritus 16.91 10.39 19 66625 4099 79673645
Sleep disorder 16.83 10.39 126 66518 85551 79592193
Dyskinesia 16.73 10.39 78 66566 44695 79633049
Bladder dilatation 16.72 10.39 14 66630 2105 79675639
Tumour marker abnormal 16.69 10.39 7 66637 287 79677457
Abdominal discomfort 16.59 10.39 132 66512 250595 79427149
Dermatitis atopic 16.58 10.39 30 66614 10026 79667718
Underdose 16.47 10.39 63 66581 33088 79644656
Body temperature fluctuation 16.38 10.39 18 66626 3789 79673955
Abnormal dreams 16.28 10.39 32 66612 11380 79666364
Incorrect route of product administration 16.24 10.39 65 66579 34864 79642880
Gaze palsy 16.14 10.39 16 66628 2989 79674755
Therapy non-responder 16.14 10.39 33 66611 92272 79585472
Electrocardiogram QT interval abnormal 16.12 10.39 7 66637 313 79677431
Chronic obstructive pulmonary disease 15.88 10.39 124 66520 85295 79592449
Electrocardiogram PR prolongation 15.78 10.39 12 66632 1571 79676173
Hepatitis 15.75 10.39 14 66630 55713 79622031
Drooling 15.74 10.39 22 66622 5912 79671832
Toxic epidermal necrolysis 15.48 10.39 9 66635 44572 79633172
Respiratory syncytial virus infection 15.44 10.39 28 66616 9374 79668370
Anticholinergic syndrome 15.41 10.39 17 66627 3594 79674150
Iron deficiency 15.35 10.39 30 66614 10624 79667120
Gallbladder enlargement 15.07 10.39 12 66632 1681 79676063
Irritable bowel syndrome 14.92 10.39 18 66626 62223 79615521
Viral infection 14.67 10.39 73 66571 42943 79634801
Metastases to lymph nodes 14.64 10.39 29 66615 10368 79667376
Cardiac failure 14.64 10.39 73 66571 154769 79522975
Rheumatic fever 14.62 10.39 3 66641 28522 79649222
Unresponsive to stimuli 14.54 10.39 88 66556 55700 79622044
Staphylococcal scalded skin syndrome 14.41 10.39 7 66637 406 79677338
Mood altered 14.38 10.39 40 66604 17807 79659937
Hepatic failure 14.36 10.39 18 66626 61194 79616550
Hypomagnesaemia 14.23 10.39 11 66633 46900 79630844
International normalised ratio increased 14.21 10.39 31 66613 84690 79593054
Nausea 14.14 10.39 954 65690 956242 78721502
Adhesive tape use 14.11 10.39 3 66641 9 79677735
Creatinine urine decreased 14.04 10.39 6 66638 258 79677486
Shunt malfunction 13.89 10.39 6 66638 265 79677479
Protrusion tongue 13.89 10.39 7 66637 440 79677304
Cytokine release syndrome 13.66 10.39 63 66581 35935 79641809
Ear infection 13.62 10.39 61 66583 34371 79643373
Hypoxia 13.59 10.39 139 66505 103104 79574640
Opisthotonus 13.55 10.39 8 66636 688 79677056
Therapeutic response decreased 13.38 10.39 22 66622 66831 79610913
Parasitic gastroenteritis 13.37 10.39 4 66640 59 79677685
Toxicity to various agents 13.37 10.39 260 66384 421280 79256464
Hepatotoxicity 13.24 10.39 14 66630 51338 79626406
Psychotic disorder 13.24 10.39 69 66575 41333 79636411
Tardive dyskinesia 13.14 10.39 28 66616 10543 79667201
Glycogen storage disease type VIII 13.07 10.39 3 66641 14 79677730
Distractibility 13.05 10.39 8 66636 737 79677007
Infection 13.04 10.39 134 66510 241578 79436166
Growth hormone-producing pituitary tumour 13.02 10.39 4 66640 65 79677679
Infusion site rash 12.92 10.39 11 66633 1691 79676053
Pleurothotonus 12.79 10.39 13 66631 2503 79675241
Peripheral swelling 12.75 10.39 154 66490 269463 79408281
Vision blurred 12.73 10.39 140 66504 105758 79571986
Nightmare 12.73 10.39 49 66595 25812 79651932
Blood viscosity abnormal 12.70 10.39 5 66639 174 79677570
Drug resistance 12.68 10.39 10 66634 42203 79635541
Electrocardiogram QRS complex prolonged 12.67 10.39 28 66616 10805 79666939
Infective pulmonary exacerbation of cystic fibrosis 12.60 10.39 31 66613 12820 79664924
Therapeutic response unexpected 12.57 10.39 41 66603 19905 79657839
Non-high-density lipoprotein cholesterol increased 12.57 10.39 6 66638 335 79677409
Liver disorder 12.56 10.39 26 66618 72391 79605353
Infusion site swelling 12.47 10.39 23 66621 7803 79669941
Drug eruption 12.46 10.39 11 66633 43924 79633820
Product confusion 12.44 10.39 3 66641 18 79677726
Snoring 12.39 10.39 19 66625 5547 79672197
Gastric hypomotility 12.36 10.39 5 66639 187 79677557
Infusion site warmth 12.29 10.39 10 66634 1445 79676299
Poisoning 12.27 10.39 3 66641 25269 79652475
Haematuria traumatic 12.23 10.39 5 66639 192 79677552
Urine ketone body present 12.23 10.39 15 66629 3550 79674194
Sinus tachycardia 12.14 10.39 62 66582 36846 79640898
Dementia with Lewy bodies 12.12 10.39 8 66636 838 79676906
Acanthosis nigricans 12.06 10.39 5 66639 199 79677545
Basophil count increased 12.00 10.39 10 66634 1493 79676251
Stupor 11.97 10.39 21 66623 6851 79670893
Skin burning sensation 11.96 10.39 31 66613 13241 79664503
Abscess intestinal 11.82 10.39 13 66631 2738 79675006
Viral diarrhoea 11.82 10.39 6 66638 383 79677361
Anticonvulsant drug level decreased 11.71 10.39 11 66633 1923 79675821
Immune effector cell-associated neurotoxicity syndrome 11.69 10.39 19 66625 5829 79671915
Death 11.68 10.39 582 66062 565932 79111812
Infusion site pain 11.65 10.39 32 66612 14144 79663600
Thrombocytopenia 11.62 10.39 154 66490 265105 79412639
Acute kidney injury 11.59 10.39 338 66306 519066 79158678
Pyrexia 11.57 10.39 457 66187 678252 78999492
Thyroid cyst 11.56 10.39 6 66638 401 79677343
Pregnancy 11.54 10.39 4 66640 26847 79650897
Pulmonary fibrosis 11.40 10.39 12 66632 44100 79633644
Gingival pain 11.37 10.39 24 66620 8974 79668770
Gastrointestinal disorder 11.33 10.39 58 66586 122147 79555597
Urinary tract infection 11.32 10.39 305 66339 274207 79403537
Liver function test abnormal 11.31 10.39 23 66621 64452 79613292
Melaena 11.31 10.39 21 66623 60869 79616875
Joint injury 11.27 10.39 54 66590 31281 79646463
Sudden unexplained death in epilepsy 11.26 10.39 7 66637 661 79677083
Neutropenia 11.20 10.39 171 66473 287539 79390205
Slow speech 11.16 10.39 12 66632 2466 79675278
Poor quality sleep 11.14 10.39 43 66601 22679 79655065
Acute myeloid leukaemia 11.06 10.39 6 66638 30879 79646865
Musculoskeletal pain 11.02 10.39 46 66598 102308 79575436
Tongue spasm 10.98 10.39 4 66640 112 79677632
Oral cavity fistula 10.90 10.39 7 66637 700 79677044
Muscle rigidity 10.90 10.39 39 66605 19843 79657901
Affect lability 10.87 10.39 27 66617 11232 79666512
Small intestine ulcer 10.79 10.39 7 66637 712 79677032
Urine leukocyte esterase positive 10.60 10.39 15 66629 4076 79673668
Allergy to arthropod sting 10.54 10.39 5 66639 275 79677469
Camptocormia 10.54 10.39 6 66638 482 79677262
Liver function test increased 10.53 10.39 63 66581 39710 79638034
Parkinsonian rest tremor 10.53 10.39 5 66639 276 79677468
Memory impairment 10.50 10.39 141 66503 111593 79566151
Activation syndrome 10.46 10.39 5 66639 280 79677464

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05CH01 NERVOUS SYSTEM
PSYCHOLEPTICS
HYPNOTICS AND SEDATIVES
Melatonin receptor agonists
MeSH PA D000975 Antioxidants
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D020011 Protective Agents
CHEBI has role CHEBI:24621 hormones
CHEBI has role CHEBI:35488 central nervous system depressants
CHEBI has role CHEBI:35623 anticonvulsants
CHEBI has role CHEBI:48578 free radical scavengers
CHEBI has role CHEBI:50847 Immunologic adjuvant
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:176497 geroprotectors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Disorders of initiating and maintaining sleep indication 194437008
Alcoholism contraindication 7200002
Psoriasis contraindication 9014002 DOID:8893
Poisoning by digitalis glycoside contraindication 12876009
Constipation contraindication 14760008 DOID:2089
Sarcoidosis contraindication 31541009 DOID:11335
Depressive disorder contraindication 35489007
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Schizophrenia contraindication 58214004 DOID:5419
Hepatic failure contraindication 59927004
Hypercalcemia contraindication 66931009 DOID:12678
Poisoning by acetaminophen contraindication 70273001
Hypercalciuria contraindication 71938000
Autoimmune disease contraindication 85828009
Kidney disease contraindication 90708001 DOID:557
Eosinophilia myalgia syndrome contraindication 95416007 DOID:998
Kidney stone contraindication 95570007
Disease of liver contraindication 235856003 DOID:409




🐶 Veterinary Drug Use

SpeciesUseRelation
Mustelids Acceleration of the fur priming cycle Indication

🐶 Veterinary products

ProductApplicantIngredients
PrimeX Wildlife Laboratories Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.29 acidic
pKa2 13.99 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Melatonin receptor type 1B GPCR AGONIST EC50 9.70 WOMBAT-PK IUPHAR
Melatonin receptor type 1A GPCR AGONIST EC50 9.40 WOMBAT-PK IUPHAR
Nuclear receptor ROR-alpha Nuclear hormone receptor EC50 9 WOMBAT-PK
Myeloperoxidase Enzyme IC50 5.52 CHEMBL
Histamine H3 receptor GPCR Ki 9.30 CHEMBL
Cytochrome P450 1B1 Enzyme Ki 4.85 CHEMBL
5-hydroxytryptamine receptor 2B GPCR ANTAGONIST Ki 5.20 IUPHAR
Ribosyldihydronicotinamide dehydrogenase [quinone] Enzyme Ki 7.56 CHEMBL
Melatonin receptor type 1B GPCR Ki 9.15 CHEMBL
Melatonin receptor GPCR Ki 9.75 CHEMBL
Melatonin receptor type 1C GPCR EC50 9.91 CHEMBL

External reference:

IDSource
4021324 VUID
N0000148757 NUI
4021324 VANDF
C0025219 UMLSCUI
CHEBI:16796 CHEBI
ML1 PDB_CHEM_ID
CHEMBL45 ChEMBL_ID
DB01065 DRUGBANK_ID
D008550 MESH_DESCRIPTOR_UI
896 PUBCHEM_CID
224 IUPHAR_LIGAND_ID
JL5DK93RCL UNII
6711 RXNORM
5037 MMSL
5609 MMSL
d04058 MMSL
005039 NDDF
116523008 SNOMEDCT_US
41199001 SNOMEDCT_US

Pharmaceutical products:

None