All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

medroxyprogesterone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
steroids, progestogens	1659	71-58-9

Description:

Molecule

Description

Molfile Inchi Smiles Synonyms: medroxyprogesterone medroxyprogesterone acetate medoxyprogesterone medroxyprogesteron depomedroxyprogesterone acetate medroprogesterone acetate hysron

A synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been used to treat breast and endometrial neoplasms. Molecular weight: 386.53 Formula: C24H34O4 CLOGP: 4.20 LIPINSKI: 0 HAC: 4 HDO: 0 TPSA: 60.44 ALOGS: -5.24 ROTB: 3 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
1.67	mg	P
5	mg	O
7	mg	P
1	g	O
1	g	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Bocci G, Oprea TI, Benet LZ
S (Water solubility)	0.02 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	44 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.06 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	15 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
June 18, 1959	FDA	PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Unintended pregnancy	1916.16	10.53	491	37506	5688	63445337
Pregnancy with injectable contraceptive	665.69	10.53	108	37889	32	63450993
Intermenstrual bleeding	404.48	10.53	159	37838	7767	63443258
Incorrect dose administered by device	400.94	10.53	135	37862	4213	63446812
Drug dose omission by device	387.83	10.53	135	37862	4666	63446359
Device leakage	319.23	10.53	130	37867	6966	63444059
Syringe issue	316.46	10.53	102	37895	2767	63448258
Heavy menstrual bleeding	276.55	10.53	157	37840	17616	63433409
Injection site abscess	233.25	10.53	66	37931	1132	63449893
Needle issue	224.11	10.53	114	37883	10262	63440763
Amenorrhoea	214.35	10.53	109	37888	9805	63441220
Device occlusion	207.10	10.53	97	37900	7290	63443735
Vaginal haemorrhage	196.02	10.53	149	37848	27338	63423687
Breast cancer	183.67	10.53	183	37814	48200	63402825
Osteopenia	169.91	10.53	120	37877	19665	63431360
Depression	144.60	10.53	345	37652	196147	63254878
Device issue	141.74	10.53	116	37881	23665	63427360
Contraindicated product administered	109.17	10.53	5	37992	217643	63233382
Oestrogen receptor assay positive	107.84	10.53	30	37967	482	63450543
Fibrocystic breast disease	101.99	10.53	35	37962	1157	63449868
Glossodynia	93.47	10.53	3	37994	178873	63272152
Injection site atrophy	92.44	10.53	28	37969	615	63450410
Uterine perforation	85.98	10.53	53	37944	6910	63444115
Menstruation irregular	85.69	10.53	53	37944	6951	63444074
Treatment failure	84.51	10.53	10	37987	199033	63251992
Progesterone receptor assay positive	84.02	10.53	23	37974	347	63450678
Pulmonary embolism	83.69	10.53	203	37794	116481	63334544
Breast cancer in situ	83.10	10.53	32	37965	1476	63449549
Pelvic pain	82.77	10.53	67	37930	13452	63437573
Incorrect dose administered	81.20	10.53	136	37861	59832	63391193
Device mechanical issue	77.13	10.53	20	37977	242	63450783
Clear cell renal cell carcinoma	76.47	10.53	30	37967	1455	63449570
Joint swelling	74.03	10.53	53	37944	327613	63123412
Drug intolerance	73.65	10.53	47	37950	308614	63142411
Uterine leiomyoma	72.56	10.53	53	37944	9145	63441880
Dysmenorrhoea	72.49	10.53	39	37958	3934	63447091
Death	71.77	10.53	71	37926	374310	63076715
Breast calcifications	70.00	10.53	27	37970	1251	63449774
Breast cancer female	68.19	10.53	60	37937	13499	63437526
Uterine haemorrhage	66.36	10.53	37	37960	4004	63447021
Postmenopausal haemorrhage	65.88	10.53	30	37967	2112	63448913
Anxiety	65.68	10.53	281	37716	217260	63233765
Renal mass	63.19	10.53	30	37967	2323	63448702
Abortion spontaneous	62.51	10.53	106	37891	47089	63403936
Wrong technique in device usage process	61.98	10.53	34	37963	3564	63447461
Hepatic enzyme increased	61.70	10.53	22	37975	202306	63248719
Systemic lupus erythematosus	61.56	10.53	24	37973	208894	63242131
Emotional distress	61.25	10.53	86	37911	32463	63418562
Breast tenderness	60.18	10.53	29	37968	2321	63448704
Rheumatoid arthritis	60.05	10.53	39	37958	253780	63197245
Product administration error	57.50	10.53	69	37928	22328	63428697
Poor quality device used	57.44	10.53	27	37970	2044	63448981
Injury	56.35	10.53	131	37866	73116	63377909
Abdominal discomfort	54.70	10.53	67	37930	320818	63130207
Synovitis	54.20	10.53	22	37975	186896	63264129
Deep vein thrombosis	52.95	10.53	139	37858	83661	63367364
Wound	52.85	10.53	16	37981	163247	63287778
Hot flush	52.64	10.53	103	37894	51056	63399969
Injection site necrosis	51.60	10.53	22	37975	1322	63449703
Product quality issue	50.77	10.53	83	37914	35782	63415243
Pyrexia	50.63	10.53	131	37866	470347	62980678
Infertility female	50.12	10.53	17	37980	542	63450483
Therapeutic product effect decreased	49.45	10.53	27	37970	193160	63257865
Off label use	48.76	10.53	223	37774	674239	62776786
Suppressed lactation	48.74	10.53	16	37981	460	63450565
Exposure via skin contact	47.12	10.53	15	37982	390	63450635
Lower respiratory tract infection	46.53	10.53	11	37986	132296	63318729
Genital haemorrhage	46.29	10.53	37	37960	7295	63443730
Uterine polyp	45.65	10.53	23	37974	2027	63448998
Infusion related reaction	45.37	10.53	48	37949	245473	63205552
Toxicity to various agents	44.95	10.53	49	37948	247201	63203824
Injection site pain	44.93	10.53	175	37822	129625	63321400
Discomfort	44.90	10.53	22	37975	167352	63283673
Breast cancer metastatic	44.72	10.53	45	37952	11973	63439052
Infertility	44.57	10.53	17	37980	764	63450261
Pericarditis	42.39	10.53	13	37984	131566	63319459
Cerebrovascular accident	41.84	10.53	151	37846	107873	63343152
Poor quality product administered	41.47	10.53	25	37972	3131	63447894
Breast disorder	38.40	10.53	22	37975	2508	63448517
Menstrual disorder	38.29	10.53	29	37968	5284	63445741
Pneumonia	37.28	10.53	144	37853	456623	62994402
Cholecystitis chronic	37.10	10.53	38	37959	10323	63440702
Mood swings	37.01	10.53	50	37947	18198	63432827
Diarrhoea	36.85	10.53	264	37733	715102	62735923
Helicobacter infection	36.21	10.53	6	37991	92779	63358246
Osteoporosis	36.10	10.53	95	37902	57243	63393782
Endometrial hyperplasia	35.77	10.53	15	37982	865	63450160
Acute kidney injury	35.17	10.53	65	37932	263350	63187675
Scar	34.63	10.53	42	37955	13740	63437285
Product use issue	34.52	10.53	49	37948	220471	63230554
Mammogram abnormal	34.42	10.53	14	37983	747	63450278
Hyperlipidaemia	34.30	10.53	50	37947	19521	63431504
Mood altered	33.94	10.53	43	37954	14700	63436325
Peripheral swelling	33.44	10.53	68	37929	265874	63185151
Blister	33.42	10.53	18	37979	129796	63321229
Stomatitis	33.21	10.53	21	37976	138704	63312321
Arthropathy	33.09	10.53	56	37941	234736	63216289
Device dislocation	33.06	10.53	57	37940	25648	63425377
Sepsis	32.94	10.53	26	37971	153097	63297928
Infection	32.91	10.53	54	37943	229119	63221906
Spinal osteoarthritis	32.29	10.53	44	37953	16142	63434883
Injection site panniculitis	32.11	10.53	5	37992	0	63451025
Device breakage	32.02	10.53	37	37960	11505	63439520
Endometrial cancer	31.06	10.53	21	37976	3204	63447821
Device delivery system issue	30.90	10.53	13	37984	756	63450269
Gastrooesophageal reflux disease	30.72	10.53	126	37871	95513	63355512
Low turnover osteopathy	30.51	10.53	23	37974	4162	63446863
Exostosis of jaw	30.29	10.53	15	37982	1274	63449751
Confusional state	30.09	10.53	60	37937	236320	63214705
Bone density decreased	29.57	10.53	40	37957	14572	63436453
Haemorrhage	29.56	10.53	92	37905	60930	63390095
Abdominal pain lower	29.25	10.53	54	37943	25624	63425401
Suicidal ideation	29.22	10.53	93	37904	62328	63388697
Incorrect route of product administration	29.12	10.53	56	37941	27396	63423629
Folliculitis	28.69	10.53	4	37993	70313	63380712
Therapeutic product effect incomplete	28.49	10.53	20	37977	125036	63325989
Pregnancy test positive	28.44	10.53	8	37989	134	63450891
Scoliosis	28.37	10.53	29	37968	7859	63443166
Coronary artery disease	28.35	10.53	61	37936	32316	63418709
Breast mass	28.27	10.53	29	37968	7893	63443132
Musculoskeletal stiffness	27.93	10.53	42	37955	184576	63266449
Ectopic pregnancy	27.84	10.53	18	37979	2549	63448476
Injection site inflammation	27.75	10.53	21	37976	3822	63447203
Fatigue	27.46	10.53	371	37626	887657	62563368
Eosinopenia	26.60	10.53	6	37991	38	63450987
Urticaria	26.51	10.53	180	37817	165622	63285403
Cervical dysplasia	26.44	10.53	19	37978	3195	63447830
Neutropenia	26.29	10.53	40	37957	174965	63276060
C-reactive protein increased	26.08	10.53	12	37985	94695	63356330
Breast hyperplasia	26.07	10.53	9	37988	303	63450722
Rash	25.99	10.53	213	37784	560658	62890367
Intentional product use issue	25.93	10.53	23	37974	127869	63323156
Intervertebral disc degeneration	25.86	10.53	39	37958	15693	63435332
General physical health deterioration	25.73	10.53	51	37946	201351	63249674
Swelling	25.66	10.53	82	37915	275296	63175729
Injection site indentation	25.58	10.53	8	37989	196	63450829
Device failure	25.15	10.53	24	37973	5987	63445038
Abnormal uterine bleeding	24.96	10.53	14	37983	1532	63449493
Stress urinary incontinence	24.28	10.53	16	37981	2339	63448686
Hyponatraemia	24.06	10.53	19	37978	111881	63339144
Dyspareunia	23.68	10.53	16	37981	2439	63448586
Embedded device	22.89	10.53	18	37979	3465	63447560
Device difficult to use	22.87	10.53	33	37964	12763	63438262
Product complaint	22.85	10.53	33	37964	12776	63438249
Breast cyst	22.83	10.53	14	37983	1807	63449218
Device use issue	22.68	10.53	16	37981	2614	63448411
Dental caries	22.57	10.53	30	37967	10749	63440276
Biopsy breast abnormal	22.54	10.53	5	37992	29	63450996
Osteonecrosis	22.38	10.53	47	37950	24483	63426542
Alopecia	22.32	10.53	115	37882	337421	63113604
Cerebral venous sinus thrombosis	21.81	10.53	14	37983	1958	63449067
Menometrorrhagia	21.66	10.53	11	37986	986	63450039
Mastectomy	21.62	10.53	13	37984	1620	63449405
Diabetes mellitus	21.58	10.53	78	37919	55732	63395293
Diverticulum	21.54	10.53	31	37966	11960	63439065
Ill-defined disorder	21.53	10.53	11	37986	81744	63369281
Injection site discolouration	21.50	10.53	25	37972	7823	63443202
Vaginal odour	21.43	10.53	9	37988	521	63450504
Completed suicide	21.20	10.53	34	37963	145639	63305386
Breast conserving surgery	21.13	10.53	11	37986	1038	63449987
Abortion missed	21.01	10.53	13	37984	1706	63449319
Mobility decreased	20.92	10.53	25	37972	121134	63329891
Emotional disorder	20.35	10.53	32	37965	13347	63437678
Oligomenorrhoea	20.28	10.53	10	37987	841	63450184
Migraine	20.12	10.53	118	37879	103228	63347797
Muscle injury	20.08	10.53	7	37990	65338	63385687
Uterine disorder	20.02	10.53	16	37981	3153	63447872
Fracture nonunion	19.88	10.53	14	37983	2281	63448744
Endometrial cancer stage I	19.62	10.53	7	37990	260	63450765
Adnexa uteri pain	19.50	10.53	8	37989	436	63450589
Injection site reaction	19.50	10.53	78	37919	58446	63392579
Cardiac failure	19.34	10.53	15	37982	89127	63361898
Withdrawal bleed	19.32	10.53	5	37992	60	63450965
Resorption bone increased	19.12	10.53	11	37986	1263	63449762
Device deployment issue	19.09	10.53	17	37980	3885	63447140
Vulvovaginal dryness	19.08	10.53	15	37982	2886	63448139
Skin laceration	18.99	10.53	42	37955	22666	63428359
Urine leukocyte esterase	18.85	10.53	6	37991	156	63450869
Anaphylactic reaction	18.84	10.53	84	37913	66016	63385009
Drug abuse	18.74	10.53	10	37987	72508	63378517
Uterine pain	18.73	10.53	7	37990	297	63450728
Endometrial atrophy	18.55	10.53	5	37992	71	63450954
Muscle fatigue	18.49	10.53	14	37983	2550	63448475
Disease progression	18.49	10.53	28	37969	122730	63328295
Cervicitis	18.47	10.53	8	37989	500	63450525
Angina unstable	18.44	10.53	22	37975	7073	63443952
Procedural pain	18.16	10.53	40	37957	21529	63429496
Knee arthroplasty	18.10	10.53	5	37992	54201	63396824
Intentional overdose	18.05	10.53	11	37986	74141	63376884
Adenomyosis	18.02	10.53	8	37989	530	63450495
Stress fracture	17.97	10.53	23	37974	7940	63443085
Coma	17.96	10.53	8	37989	64356	63386669
Pregnancy with implant contraceptive	17.92	10.53	14	37983	2669	63448356
Internal injury	17.85	10.53	7	37990	339	63450686
Deformity	17.84	10.53	28	37969	11656	63439369
Thyrotoxic periodic paralysis	17.78	10.53	4	37993	25	63451000
Postmortem blood drug level abnormal	17.62	10.53	7	37990	351	63450674
Osteomyelitis	17.29	10.53	44	37953	25976	63425049
Liquid product physical issue	17.20	10.53	10	37987	1172	63449853
Medical device discomfort	17.20	10.53	12	37985	1927	63449098
Device defective	17.07	10.53	12	37985	1950	63449075
Gastrointestinal disorder	16.96	10.53	33	37964	131206	63319819
Placenta accreta	16.89	10.53	6	37991	220	63450805
Benign breast neoplasm	16.75	10.53	10	37987	1230	63449795
Decidual cast	16.73	10.53	3	37994	4	63451021
Femur fracture	16.69	10.53	59	37938	41697	63409328
Delayed puberty	16.67	10.53	5	37992	106	63450919
Delirium	16.26	10.53	5	37992	50536	63400489
Breast reconstruction	16.18	10.53	6	37991	249	63450776
Liver injury	16.15	10.53	8	37989	60512	63390513
Acne	16.11	10.53	40	37957	23253	63427772
Febrile neutropenia	15.99	10.53	29	37968	118420	63332605
Neurofibroma	15.97	10.53	3	37994	6	63451019
Blood oestrogen decreased	15.89	10.53	6	37991	262	63450763
Libido decreased	15.84	10.53	13	37984	2659	63448366
Renal failure	15.71	10.53	29	37968	117623	63333402
Pancytopenia	15.69	10.53	21	37976	96912	63354113
Psoriatic arthropathy	15.67	10.53	19	37978	91501	63359524
Oral infection	15.62	10.53	17	37980	4951	63446074
Thrombocytopenia	15.51	10.53	43	37954	151114	63299911
Renal impairment	15.50	10.53	18	37979	88337	63362688
Toothache	15.48	10.53	35	37962	19164	63431861
Modified radical mastectomy	15.37	10.53	3	37994	8	63451017
Weight increased	15.33	10.53	230	37767	260562	63190463
Meniscus injury	15.20	10.53	20	37977	7094	63443931
Complication of device removal	15.14	10.53	17	37980	5125	63445900
Uterine injury	15.02	10.53	4	37993	54	63450971
Cerebral palsy	14.94	10.53	5	37992	153	63450872
Intentional device misuse	14.93	10.53	8	37989	800	63450225
Endometrial hypertrophy	14.91	10.53	6	37991	311	63450714
Lipoatrophy	14.81	10.53	6	37991	317	63450708
Livedo reticularis	14.77	10.53	12	37985	2420	63448605
Liver iron concentration abnormal	14.76	10.53	4	37993	58	63450967
Oestrogen deficiency	14.75	10.53	5	37992	159	63450866
Breast necrosis	14.72	10.53	5	37992	160	63450865
Large intestine polyp	14.52	10.53	21	37976	8136	63442889
Galactorrhoea	14.45	10.53	15	37982	4140	63446885
Product packaging issue	14.43	10.53	9	37988	1197	63449828
Foot fracture	14.42	10.53	39	37958	23875	63427150
Lumbar spinal stenosis	14.29	10.53	16	37981	4806	63446219
Injection site abscess sterile	14.07	10.53	3	37994	14	63451011
Cardiac arrest	14.04	10.53	21	37976	92524	63358501
Intramedullary rod insertion	14.01	10.53	11	37986	2112	63448913
Chlamydial infection	14.00	10.53	6	37991	365	63450660
Injection site induration	13.94	10.53	22	37975	9204	63441821
Mitral valve incompetence	13.93	10.53	34	37963	19560	63431465
Bradycardia	13.86	10.53	14	37983	73213	63377812
Anhedonia	13.67	10.53	24	37973	10950	63440075
Radiotherapy	13.58	10.53	6	37991	393	63450632
Loss of libido	13.51	10.53	9	37988	1340	63449685
Circumstance or information capable of leading to medication error	13.51	10.53	14	37983	3856	63447169
Anaemia postoperative	13.49	10.53	11	37986	2231	63448794
Immunoglobulin G4 related disease	13.42	10.53	4	37993	83	63450942
Breast pain	13.32	10.53	21	37976	8777	63442248
Uterine spasm	13.31	10.53	7	37990	674	63450351
Post procedural cellulitis	13.28	10.53	4	37993	86	63450939
Inappropriate schedule of product administration	13.26	10.53	107	37890	103858	63347167
Crystalluria	13.25	10.53	6	37991	417	63450608
Hospitalisation	13.20	10.53	19	37978	85062	63365963
Hip arthroplasty	13.17	10.53	6	37991	47640	63403385
Pituitary tumour recurrent	13.16	10.53	4	37993	89	63450936
Injection site discomfort	13.11	10.53	15	37982	4615	63446410
Muscle spasms	13.08	10.53	147	37850	156003	63295022
Seborrhoeic keratosis	13.07	10.53	11	37986	2331	63448694
Panic attack	13.04	10.53	36	37961	22295	63428730
Red blood cell sedimentation rate increased	13.02	10.53	5	37992	43977	63407048
Hyperkeratosis	12.99	10.53	17	37980	6001	63445024
Mitral valve prolapse	12.86	10.53	11	37986	2382	63448643
Myocardial infarction	12.84	10.53	103	37894	99790	63351235
Mucosal inflammation	12.83	10.53	6	37991	46922	63404103
Drug ineffective for unapproved indication	12.65	10.53	47	37950	34016	63417009
Complication associated with device	12.65	10.53	30	37967	16948	63434077
Osteoarthritis	12.63	10.53	99	37898	95244	63355781
Fine motor skill dysfunction	12.60	10.53	15	37982	4810	63446215
Gingivitis	12.60	10.53	20	37977	8409	63442616
Menopausal symptoms	12.59	10.53	11	37986	2450	63448575
Anticonvulsant drug level increased	12.55	10.53	9	37988	1508	63449517
Post procedural discomfort	12.55	10.53	8	37989	1106	63449919
Tic	12.54	10.53	9	37988	1511	63449514
Cartilage injury	12.53	10.53	10	37987	1967	63449058
Nasopharyngitis	12.46	10.53	95	37902	254162	63196863
Pregnancy test urine positive	12.37	10.53	3	37994	27	63450998
Uterine cervix stenosis	12.32	10.53	5	37992	265	63450760
Insomnia	12.32	10.53	189	37808	215063	63235962
Medical device pain	12.23	10.53	9	37988	1571	63449454
Acne cystic	12.12	10.53	6	37991	509	63450516
Product administered at inappropriate site	12.10	10.53	12	37985	3137	63447888
Breast fibrosis	12.00	10.53	3	37994	31	63450994
Respiratory failure	11.99	10.53	27	37970	101831	63349194
Fear	11.90	10.53	28	37969	15738	63435287
Cardio-respiratory arrest	11.89	10.53	11	37986	59948	63391077
Nocturia	11.73	10.53	19	37978	8122	63442903
Ovarian cyst	11.69	10.53	28	37969	15917	63435108
Injection site cellulitis	11.68	10.53	8	37989	1246	63449779
HIV test positive	11.67	10.53	3	37994	35	63450990
Gallbladder disorder	11.63	10.53	31	37966	18811	63432214
Adenoma benign	11.61	10.53	7	37990	877	63450148
Cholecystectomy	11.59	10.53	22	37975	10655	63440370
Anger	11.52	10.53	24	37973	12432	63438593
Thyroid disorder	11.52	10.53	27	37970	15135	63435890
Breast disorder female	11.52	10.53	4	37993	137	63450888
Endometriosis	11.44	10.53	15	37982	5305	63445720
Hepatic function abnormal	11.37	10.53	4	37993	37138	63413887
Maternal exposure during pregnancy	11.36	10.53	81	37916	219981	63231044
Atrophic vulvovaginitis	11.33	10.53	9	37988	1759	63449266
Pregnancy with contraceptive device	11.30	10.53	14	37983	4680	63446345
Hypothyroidism	11.27	10.53	53	37944	42579	63408446
Protein urine present	11.26	10.53	16	37981	6104	63444921
Drug exposure before pregnancy	11.25	10.53	7	37990	927	63450098
Ventricular hypertrophy	11.23	10.53	12	37985	3424	63447601
Wrong product administered	11.21	10.53	16	37981	6125	63444900
Feelings of worthlessness	11.16	10.53	5	37992	339	63450686
Complication of pregnancy	11.07	10.53	6	37991	614	63450411
Condition aggravated	10.97	10.53	172	37825	402045	63048980
Cervicobrachial syndrome	10.96	10.53	7	37990	970	63450055
Dehydration	10.92	10.53	60	37937	173294	63277731
Hirsutism	10.92	10.53	8	37989	1387	63449638
Marital problem	10.84	10.53	4	37993	164	63450861
Therapy interrupted	10.82	10.53	3	37994	32452	63418573
Fat necrosis	10.72	10.53	6	37991	654	63450371
Porphyria	10.70	10.53	4	37993	170	63450855
Hypotension	10.64	10.53	108	37889	272496	63178529
Injection site infection	10.58	10.53	9	37988	1934	63449091
Hormone level abnormal	10.55	10.53	10	37987	2473	63448552

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Head titubation	118.88	36.16	18	754	393	34955766
Cogwheel rigidity	97.47	36.16	18	754	1334	34954825
Sedation complication	74.38	36.16	15	757	1762	34954397
Extrapyramidal disorder	74.25	36.16	22	750	12858	34943301
Serotonin syndrome	64.80	36.16	22	750	19911	34936248
Anticholinergic syndrome	54.80	36.16	11	761	1258	34954901
Porphyria non-acute	38.36	36.16	7	765	482	34955677
Sexually inappropriate behaviour	38.04	36.16	7	765	505	34955654
Exposure during pregnancy	37.58	36.16	12	760	8922	34947237

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Unintended pregnancy	1097.00	11.47	261	29134	3672	79711321
Pregnancy with injectable contraceptive	539.41	11.47	82	29313	32	79714961
Intermenstrual bleeding	273.97	11.47	97	29298	5787	79709206
Vaginal haemorrhage	199.17	11.47	115	29280	21702	79693291
Incorrect dose administered by device	197.66	11.47	73	29322	4916	79710077
Amenorrhoea	196.83	11.47	82	29313	7610	79707383
Drug dose omission by device	192.10	11.47	76	29319	6174	79708819
Heavy menstrual bleeding	186.95	11.47	95	29300	13916	79701077
Injection site abscess	158.25	11.47	47	29348	1593	79713400
Osteopenia	152.35	11.47	91	29304	18273	79696720
Depression	149.16	11.47	278	29117	216512	79498481
Device leakage	120.26	11.47	65	29330	10791	79704202
Needle issue	119.56	11.47	69	29326	12999	79701994
Uterine perforation	108.89	11.47	51	29344	6252	79708741
Oestrogen receptor assay positive	108.27	11.47	25	29370	305	79714688
Injection site atrophy	102.22	11.47	25	29370	396	79714597
Breast cancer in situ	95.16	11.47	28	29367	918	79714075
Syringe issue	90.75	11.47	45	29350	6253	79708740
Fibrocystic breast disease	90.69	11.47	25	29370	645	79714348
Device issue	88.26	11.47	76	29319	27032	79687961
Abortion spontaneous	86.62	11.47	78	29317	29429	79685564
Menstruation irregular	84.69	11.47	40	29355	4996	79709997
Progesterone receptor assay positive	82.50	11.47	19	29376	229	79714764
Pelvic pain	80.20	11.47	54	29341	13327	79701666
Breast cancer	77.64	11.47	78	29317	33703	79681290
Death	76.91	11.47	58	29337	566456	79148537
Uterine leiomyoma	75.36	11.47	40	29355	6403	79708590
Injury	75.26	11.47	116	29279	77380	79637613
Clear cell renal cell carcinoma	74.55	11.47	30	29365	2546	79712447
Pulmonary embolism	68.57	11.47	177	29218	171477	79543516
Emotional distress	68.47	11.47	79	29316	39890	79675103
Renal mass	67.04	11.47	30	29365	3310	79711683
Postmenopausal haemorrhage	62.54	11.47	23	29372	1529	79713464
Genital haemorrhage	62.52	11.47	35	29360	6220	79708773
Acute kidney injury	62.14	11.47	60	29335	519344	79195649
Uterine haemorrhage	61.24	11.47	27	29368	2876	79712117
Anxiety	59.44	11.47	214	29181	248298	79466695
Breast cancer female	58.71	11.47	42	29353	11419	79703574
Device dislocation	52.53	11.47	56	29339	25914	79689079
Device occlusion	50.72	11.47	39	29356	11827	79703166
Pyrexia	49.31	11.47	111	29284	678598	79036395
Uterine polyp	47.76	11.47	19	29376	1565	79713428
Breast calcifications	46.67	11.47	16	29379	866	79714127
Contraindicated product administered	46.23	11.47	3	29392	157535	79557458
Dysmenorrhoea	44.59	11.47	22	29373	3023	79711970
Neutropenia	43.61	11.47	26	29369	287684	79427309
Hot flush	42.25	11.47	74	29321	54803	79660190
Injection site necrosis	42.04	11.47	17	29378	1461	79713532
Pneumonia	41.70	11.47	116	29279	660130	79054863
Sepsis	41.33	11.47	24	29371	269404	79445589
Treatment failure	40.53	11.47	7	29388	170479	79544514
Osteoporosis	40.41	11.47	72	29323	54040	79660953
Toxicity to various agents	40.39	11.47	58	29337	421482	79293511
Injection site pain	39.18	11.47	121	29274	129717	79585276
Cholecystitis chronic	38.97	11.47	31	29364	9875	79705118
Menstrual disorder	38.60	11.47	22	29373	4045	79710948
Cerebrovascular accident	37.32	11.47	134	29261	155158	79559835
Gastrooesophageal reflux disease	37.05	11.47	103	29292	104143	79610850
Mood swings	36.94	11.47	41	29354	19839	79695154
Drug abuse	35.90	11.47	8	29387	162683	79552310
Scoliosis	35.16	11.47	26	29369	7438	79707555
Injection site panniculitis	34.53	11.47	5	29390	0	79714993
Dyspareunia	34.46	11.47	16	29379	1922	79713071
Mammogram abnormal	34.41	11.47	11	29384	478	79714515
Abdominal pain lower	34.30	11.47	50	29345	31732	79683261
Product administration error	34.22	11.47	50	29345	31796	79683197
Exostosis of jaw	34.22	11.47	14	29381	1240	79713753
Low turnover osteopathy	34.09	11.47	16	29379	1970	79713023
Breast disorder	33.38	11.47	16	29379	2065	79712928
Endometrial cancer	33.28	11.47	16	29379	2078	79712915
Scar	32.93	11.47	34	29361	15162	79699831
Abnormal uterine bleeding	32.80	11.47	13	29382	1060	79713933
Stress urinary incontinence	32.08	11.47	15	29380	1831	79713162
Breast tenderness	32.07	11.47	16	29379	2252	79712741
Poor quality device used	31.95	11.47	16	29379	2269	79712724
Embedded device	31.63	11.47	18	29377	3301	79711692
Endometrial hyperplasia	31.57	11.47	11	29384	625	79714368
Wrong technique in device usage process	30.92	11.47	19	29376	4009	79710984
Off label use	29.88	11.47	204	29191	907011	78807982
Porphyria non-acute	29.81	11.47	11	29384	738	79714255
Hyperlipidaemia	29.54	11.47	42	29353	26051	79688942
Vulvovaginal dryness	29.42	11.47	15	29380	2209	79712784
Pregnancy test positive	29.36	11.47	7	29388	99	79714894
Device breakage	28.94	11.47	27	29368	10648	79704345
Urticaria	28.90	11.47	140	29255	185061	79529932
Spinal osteoarthritis	28.22	11.47	33	29362	16894	79698099
Osteonecrosis	28.02	11.47	45	29350	31050	79683943
Migraine	27.75	11.47	83	29312	87410	79627583
Eosinopenia	27.74	11.47	6	29389	53	79714940
Device failure	27.69	11.47	21	29374	6240	79708753
Deformity	27.41	11.47	25	29370	9580	79705413
Procedural pain	27.39	11.47	38	29357	23046	79691947
Infertility female	27.13	11.47	9	29386	440	79714553
Hepatic enzyme increased	26.96	11.47	17	29378	182593	79532400
Osteoarthritis	26.92	11.47	82	29313	87227	79627766
Complication of device removal	26.48	11.47	17	29378	3872	79711121
Deep vein thrombosis	26.25	11.47	101	29294	120818	79594175
Cerebral venous sinus thrombosis	26.16	11.47	14	29381	2277	79712716
Hyponatraemia	25.65	11.47	17	29378	177831	79537162
Intervertebral disc degeneration	25.03	11.47	30	29365	15755	79699238
Endometrial cancer stage I	24.98	11.47	7	29388	192	79714801
Benign breast neoplasm	24.81	11.47	10	29385	852	79714141
Dental caries	24.81	11.47	26	29369	11794	79703199
Breast reconstruction	24.30	11.47	6	29389	99	79714894
Renal failure	24.22	11.47	23	29372	200945	79514048
Exposure during pregnancy	24.05	11.47	87	29308	101045	79613948
Device mechanical issue	24.02	11.47	8	29387	396	79714597
Head titubation	23.99	11.47	10	29385	928	79714065
Febrile neutropenia	23.91	11.47	30	29365	230969	79484024
Toothache	23.88	11.47	33	29362	19937	79695056
Uterine disorder	23.84	11.47	13	29382	2194	79712799
Device difficult to use	23.83	11.47	27	29368	13358	79701635
Medical device discomfort	23.70	11.47	12	29383	1742	79713251
Completed suicide	23.33	11.47	34	29361	245733	79469260
Infertility	23.21	11.47	9	29386	692	79714301
Cardiac arrest	22.80	11.47	18	29377	172078	79542915
Diarrhoea	22.49	11.47	212	29183	880277	78834716
Injection site reaction	22.36	11.47	57	29338	54728	79660265
Bradycardia	22.35	11.47	11	29384	135546	79579447
Adenomyosis	22.15	11.47	7	29388	293	79714700
Thrombocytopenia	22.08	11.47	40	29355	265219	79449774
Cardiac failure	22.06	11.47	15	29380	154827	79560166
Lower respiratory tract infection	22.05	11.47	10	29385	129210	79585783
Weight increased	21.92	11.47	176	29219	277210	79437783
Diabetes mellitus	21.75	11.47	71	29324	78319	79636674
Rheumatoid arthritis	21.65	11.47	27	29368	208443	79506550
Exposure via skin contact	21.51	11.47	7	29388	322	79714671
Confusional state	21.43	11.47	54	29341	317943	79397050
Product quality issue	21.39	11.47	42	29353	33898	79681095
Injection site inflammation	21.36	11.47	15	29380	3961	79711032
Cervical dysplasia	21.35	11.47	12	29383	2149	79712844
Insomnia	21.28	11.47	159	29236	245011	79469982
Adnexa uteri pain	21.09	11.47	7	29388	343	79714650
Joint swelling	21.06	11.47	47	29348	288599	79426394
Ectopic pregnancy	20.89	11.47	11	29384	1732	79713261
Injection site indentation	20.71	11.47	6	29389	186	79714807
Emotional disorder	20.65	11.47	26	29369	14361	79700632
Therapeutic product effect decreased	20.64	11.47	18	29377	163845	79551148
Bone density decreased	20.57	11.47	25	29370	13322	79701671
Internal injury	20.54	11.47	7	29388	372	79714621
C-reactive protein increased	20.48	11.47	11	29384	129016	79585977
Urine leukocyte esterase	20.44	11.47	6	29389	195	79714798
Pregnancy with contraceptive device	20.13	11.47	14	29381	3640	79711353
Breast mass	20.10	11.47	18	29377	6736	79708257
Disease progression	20.08	11.47	23	29372	184339	79530654
Vaginal odour	19.76	11.47	7	29388	418	79714575
Resorption bone increased	19.67	11.47	10	29385	1465	79713528
Pericarditis	19.52	11.47	7	29388	104229	79610764
Oligomenorrhoea	19.45	11.47	8	29387	718	79714275
Fracture nonunion	19.37	11.47	10	29385	1512	79713481
Drug intolerance	19.27	11.47	43	29352	264076	79450917
Renal impairment	19.08	11.47	18	29377	157765	79557228
Intentional device misuse	18.85	11.47	8	29387	777	79714216
Gallbladder disorder	18.83	11.47	29	29366	19311	79695682
Stress fracture	18.76	11.47	17	29378	6463	79708530
Osteomyelitis	18.72	11.47	39	29356	32826	79682167
Oral infection	18.57	11.47	16	29379	5691	79709302
Therapeutic product effect incomplete	18.53	11.47	15	29380	141630	79573363
Skin laceration	18.45	11.47	36	29359	28926	79686067
Prolactin-producing pituitary tumour	18.44	11.47	5	29390	121	79714872
Maternal drugs affecting foetus	18.42	11.47	10	29385	1673	79713320
Ovarian cyst	18.37	11.47	23	29372	12632	79702361
General physical health deterioration	18.34	11.47	47	29348	275191	79439802
Muscle fatigue	18.26	11.47	13	29382	3506	79711487
Modified radical mastectomy	18.18	11.47	3	29392	4	79714989
Decidual cast	18.18	11.47	3	29392	4	79714989
Drug interaction	18.14	11.47	85	29310	415098	79299895
Abortion missed	17.99	11.47	9	29386	1274	79713719
Breast cyst	17.96	11.47	9	29386	1278	79713715
Intentional product use issue	17.64	11.47	18	29377	152094	79562899
Lumbar spinal stenosis	17.58	11.47	15	29380	5267	79709726
Breast hyperplasia	17.45	11.47	5	29390	149	79714844
Fine motor skill dysfunction	17.39	11.47	15	29380	5342	79709651
Blood oestrogen decreased	17.35	11.47	5	29390	152	79714841
Synovitis	17.30	11.47	18	29377	150716	79564277
Endometrial atrophy	17.23	11.47	4	29391	50	79714943
Uterine injury	17.23	11.47	4	29391	50	79714943
Respiratory failure	17.19	11.47	25	29370	180886	79534107
Medical device pain	17.06	11.47	9	29386	1422	79713571
Menopausal symptoms	16.99	11.47	10	29385	1953	79713040
Ovarian cancer	16.97	11.47	13	29382	3921	79711072
Postmortem blood drug level abnormal	16.82	11.47	7	29388	647	79714346
Post procedural discomfort	16.69	11.47	8	29387	1032	79713961
Liver iron concentration abnormal	16.68	11.47	4	29391	58	79714935
Complication of pregnancy	16.67	11.47	6	29389	375	79714618
Pancytopenia	16.65	11.47	22	29373	165723	79549270
Uterine pain	16.49	11.47	5	29390	182	79714811
Cartilage injury	16.42	11.47	9	29386	1534	79713459
Delayed puberty	16.36	11.47	5	29390	187	79714806
Stomatitis	16.31	11.47	18	29377	146739	79568254
Coronary artery disease	16.14	11.47	57	29338	65417	79649576
Cerebral palsy	16.13	11.47	5	29390	196	79714797
Device use issue	16.12	11.47	11	29384	2773	79712220
Foot fracture	16.09	11.47	29	29366	21952	79693041
Post procedural cellulitis	15.98	11.47	4	29391	70	79714923
Suicidal ideation	15.94	11.47	63	29332	76277	79638716
Placenta accreta	15.85	11.47	5	29390	208	79714785
Throat tightness	15.76	11.47	33	29362	27874	79687119
Biopsy breast abnormal	15.70	11.47	3	29392	13	79714980
Galactorrhoea	15.62	11.47	12	29383	3634	79711359
Uterine cervix stenosis	15.58	11.47	5	29390	220	79714773
Discomfort	15.58	11.47	14	29381	125603	79589390
Wound	15.58	11.47	12	29383	116167	79598826
Femur fracture	15.55	11.47	40	29355	38612	79676381
Intentional overdose	15.45	11.47	10	29385	105950	79609043
Diverticulum	15.44	11.47	23	29372	14873	79700120
Breast necrosis	15.43	11.47	4	29391	81	79714912
Oestrogen deficiency	15.38	11.47	4	29391	82	79714911
Coma	15.37	11.47	9	29386	100640	79614353
Hyperkalaemia	15.10	11.47	12	29383	114386	79600607
Septic shock	14.85	11.47	14	29381	122787	79592206
Cardio-respiratory arrest	14.81	11.47	11	29384	108499	79606494
Infection	14.81	11.47	43	29352	241669	79473324
Uterine spasm	14.67	11.47	6	29389	531	79714462
Interstitial lung disease	14.63	11.47	12	29383	112588	79602405
Sexually inappropriate behaviour	14.58	11.47	6	29389	539	79714454
Meniscus injury	14.41	11.47	15	29380	6753	79708240
Hyperkeratosis	14.36	11.47	16	29379	7774	79707219
Blood cholesterol increased	14.30	11.47	65	29330	83655	79631338
Lumbar radiculopathy	14.26	11.47	9	29386	1990	79713003
Gingivitis	14.07	11.47	17	29378	9004	79705989
Unwanted pregnancy	14.03	11.47	3	29392	25	79714968
Blister	14.01	11.47	14	29381	119462	79595531
Mitral valve prolapse	13.83	11.47	9	29386	2098	79712895
Premature menopause	13.82	11.47	6	29389	616	79714377
Atrial fibrillation	13.80	11.47	33	29362	197853	79517140
Drug exposure before pregnancy	13.73	11.47	6	29389	626	79714367
Hepatic function abnormal	13.53	11.47	5	29390	73102	79641891
Cholecystectomy	13.46	11.47	17	29378	9415	79705578
Hypotension	13.46	11.47	101	29294	440216	79274777
Vaginal discharge	13.20	11.47	15	29380	7448	79707545
Hypoaesthesia	13.19	11.47	112	29283	179240	79535753
Platelet count decreased	13.15	11.47	33	29362	194631	79520362
Multiple organ dysfunction syndrome	13.09	11.47	15	29380	120231	79594762
Pain in jaw	12.98	11.47	42	29353	46109	79668884
Menometrorrhagia	12.98	11.47	6	29389	714	79714279
Injection site discolouration	12.95	11.47	15	29380	7599	79707394
Thyrotoxic periodic paralysis	12.90	11.47	4	29391	157	79714836
Cogwheel rigidity	12.87	11.47	10	29385	3078	79711915
Anaphylactic reaction	12.83	11.47	63	29332	83680	79631313
Progesterone decreased	12.82	11.47	3	29392	39	79714954
Nitrite urine present	12.73	11.47	7	29388	1202	79713791
Complication associated with device	12.70	11.47	23	29372	17473	79697520
Mucosal inflammation	12.66	11.47	6	29389	75574	79639419
Bacterial test	12.65	11.47	7	29388	1216	79713777
Spondylolisthesis	12.62	11.47	10	29385	3165	79711828
Helicobacter infection	12.52	11.47	5	29390	69699	79645294
Withdrawal bleed	12.48	11.47	3	29392	44	79714949
Atrophic vulvovaginitis	12.45	11.47	7	29388	1254	79713739
Fear	12.42	11.47	26	29369	21960	79693033
Endometrial hypertrophy	12.38	11.47	4	29391	180	79714813
Pregnancy with implant contraceptive	12.36	11.47	8	29387	1848	79713145
Livedo reticularis	12.34	11.47	11	29384	4092	79710901
Cholelithiasis	12.26	11.47	45	29350	52619	79662374
Pituitary tumour recurrent	12.19	11.47	4	29391	189	79714804
Thyroid disorder	12.17	11.47	20	29375	14059	79700934
Morton's neuralgia	12.12	11.47	3	29392	50	79714943
Device defective	12.11	11.47	8	29387	1912	79713081
Carpal tunnel syndrome	12.10	11.47	24	29371	19504	79695489
Device use error	12.10	11.47	14	29381	7087	79707906
Incorrect dose administered	11.99	11.47	58	29337	76572	79638421
Anticonvulsant drug level increased	11.96	11.47	9	29386	2644	79712349
Mitral valve incompetence	11.95	11.47	30	29365	28535	79686458
Hormone level abnormal	11.81	11.47	8	29387	1994	79712999
Hypoglycaemia	11.80	11.47	12	29383	101582	79613411
Device expulsion	11.71	11.47	28	29367	25833	79689160
Pain in extremity	11.68	11.47	194	29201	364344	79350649
Complex regional pain syndrome	11.64	11.47	8	29387	2040	79712953
Injection site swelling	11.59	11.47	41	29354	47091	79667902
Blood creatinine increased	11.50	11.47	25	29370	155032	79559961
Feeling abnormal	11.49	11.47	99	29296	159100	79555893
Ligament sprain	11.47	11.47	19	29376	13445	79701548

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	G03AA08	GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE Progestogens and estrogens, fixed combinations
ATC	G03AA17	GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE Progestogens and estrogens, fixed combinations
ATC	G03AC06	GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE Progestogens
ATC	G03DA02	GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM PROGESTOGENS Pregnen (4) derivatives
ATC	G03FA12	GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM PROGESTOGENS AND ESTROGENS IN COMBINATION Progestogens and estrogens, fixed combinations
ATC	G03FB06	GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM PROGESTOGENS AND ESTROGENS IN COMBINATION Progestogens and estrogens, sequential preparations
ATC	L02AB02	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ENDOCRINE THERAPY HORMONES AND RELATED AGENTS Progestogens
FDA CS	M0447349	Progesterone Congeners
MeSH PA	D003270	Contraceptive Agents
MeSH PA	D003271	Contraceptive Agents, Female
MeSH PA	D000080066	Contraceptive Agents, Hormonal
MeSH PA	D003278	Contraceptives, Oral, Hormonal
MeSH PA	D003280	Contraceptives, Oral, Synthetic
MeSH PA	D012102	Reproductive Control Agents
CHEBI has role	CHEBI:49323	contraceptive drugs
CHEBI has role	CHEBI:49326	synthetic oral contraceptives
CHEBI has role	CHEBI:59826	progestins
CHEBI has role	CHEBI:22586	antioxidants
CHEBI has role	CHEBI:35222	inhibitor
CHEBI has role	CHEBI:35610	antineoplastic agents
CHEBI has role	CHEBI:49324	female contraceptive drugs
CHEBI has role	CHEBI:50113	androgene
CHEBI has role	CHEBI:60809	adjuvants
FDA EPC	N0000175602	Progestin
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D018931	Antineoplastic Agents, Hormonal
MeSH PA	D003272	Contraceptive Agents, Male

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Contraception	indication	13197004
Dysfunctional uterine bleeding	indication	19155002
Atrophic vaginitis	indication	52441000
Secondary physiologic amenorrhea	indication	86030004
Secondary malignant neoplasm of kidney	indication	94360002
Postmenopausal osteoporosis	indication	102447009
Endometriosis	indication	129103003
Menopausal flushing	indication	198436008
Endometrial carcinoma	indication	254878006	DOID:2871
Prevention of premature ovulation during controlled ovarian stimulation	indication	732970000
Endometrial Hyperplasia Prevention	indication
Polycystic ovaries	off-label use	69878008
Precocious puberty	off-label use	400179000
Endogenous Estrogen Production Test	off-label use
Hyperlipoproteinemia	contraindication	3744001	DOID:1168
Hypocalcemia	contraindication	5291005
Alcoholism	contraindication	7200002
Weight gain finding	contraindication	8943002
Hypercholesterolemia	contraindication	13644009
Myocardial infarction	contraindication	22298006	DOID:5844
Fibroadenosis of breast	contraindication	23260002	DOID:10352
Depressive disorder	contraindication	35489007
Chloasma	contraindication	36209000
Migraine	contraindication	37796009	DOID:6364
Hypertensive disorder	contraindication	38341003	DOID:10763
Disorder of gallbladder	contraindication	39621005	DOID:0060262
Hypothyroidism	contraindication	40930008	DOID:1459
Body fluid retention	contraindication	43498006
Thrombosis of retinal vein	contraindication	46085004
Humoral hypercalcemia of malignancy	contraindication	47709007
Dementia	contraindication	52448006
Hepatic porphyria	contraindication	55056006	DOID:3133
Systemic lupus erythematosus	contraindication	55464009	DOID:9074
Hyperlipidemia	contraindication	55822004	DOID:1168
Anorexia nervosa	contraindication	56882008	DOID:8689
Hepatic failure	contraindication	59927004
Cerebrovascular disease	contraindication	62914000	DOID:6713
Thrombophlebitis	contraindication	64156001	DOID:3875
Osteoporosis	contraindication	64859006	DOID:11476
Intermenstrual bleeding - irregular	contraindication	64996003
Diabetes mellitus	contraindication	73211009	DOID:9351
Epilepsy	contraindication	84757009	DOID:1826
Breast lump	contraindication	89164003
Kidney disease	contraindication	90708001	DOID:557
Uterine leiomyoma	contraindication	95315005	DOID:13223
Deep venous thrombosis	contraindication	128053003
Mammography abnormal	contraindication	168750009
Asthma	contraindication	195967001	DOID:2841
Cerebrovascular accident	contraindication	230690007
Pulmonary thromboembolism	contraindication	233935004
Thrombophilia	contraindication	234467004	DOID:2452
Disease of liver	contraindication	235856003	DOID:409
Chorea	contraindication	271700006
Pregnancy, function	contraindication	289908002
Hypertriglyceridemia	contraindication	302870006
Osteopenia	contraindication	312894000
Functional visual loss	contraindication	313165001
Malignant tumor of ovary	contraindication	363443007	DOID:2394
Thromboembolic disorder	contraindication	371039008
Cardiovascular event risk	contraindication	395112001
Disorder of coronary artery	contraindication	414024009
Obesity	contraindication	414916001	DOID:9970
Estrogen receptor positive tumor	contraindication	416053008
Family history of malignant neoplasm of breast	contraindication	429740004
Hypertensive urgency	contraindication	443482000
Carcinoma of female breast	contraindication	447782002
Smokes tobacco daily	contraindication	449868002

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Progesterone receptor	Nuclear hormone receptor	P06401	PRGR_HUMAN	AGONIST	EC50	9.59		WOMBAT-PK	CHEMBL
Glucocorticoid receptor	Nuclear hormone receptor	P04150	GCR_HUMAN		Ki	7.88		CHEMBL
Mineralocorticoid receptor	Nuclear hormone receptor	P08235	MCR_HUMAN		IC50	5.92		CHEMBL
Androgen receptor	Nuclear hormone receptor	P10275	ANDR_HUMAN		EC50	8.20		WOMBAT-PK
Aldo-keto reductase family 1 member C1	Enzyme	Q04828	AK1C1_HUMAN		IC50	5.74		CHEMBL
Aldo-keto reductase family 1 member C2	Enzyme	P52895	AK1C2_HUMAN		IC50	5.39		CHEMBL
Aldo-keto reductase family 1 member C3	Enzyme	P42330	AK1C3_HUMAN		IC50	6.52		CHEMBL
Cytochrome P450 2C19	Enzyme	P33261	CP2CJ_HUMAN		IC50	5.70		DRUG MATRIX
Sex hormone-binding globulin	Secreted	P04278	SHBG_HUMAN		Kd	6.20		CHEMBL
Histamine H2 receptor	GPCR	P25021	HRH2_HUMAN		Ki	4.56		DRUG MATRIX
Estrogen receptor	Nuclear hormone receptor	P03372 Q92731	ESR1_HUMAN ESR2_HUMAN		IC50	6.03		CHEMBL
Androgen receptor	Transcription factor		ANDR_RAT		IC50	7.45		CHEMBL
Progesterone receptor	Transcription factor		Q690N0_BOVIN		Ki	7.03		DRUG MATRIX
Androgen receptor	Transcription factor		ANDR_MOUSE		EC50	8.21		CHEMBL

External reference:

ID	Source
4019810	VUID
N0000147899	NUI
D00951	KEGG_DRUG
4017828	VANDF
4019810	VANDF
C0025147	UMLSCUI
CHEBI:6715	CHEBI
CHEMBL717	ChEMBL_ID
D008525	MESH_DESCRIPTOR_UI
10631	PUBCHEM_CID
2879	IUPHAR_LIGAND_ID
853	INN_ID
HSU1C9YRES	UNII
DB00603	DRUGBANK_ID
1000112	RXNORM
5032	MMSL
7121	MMSL
d00284	MMSL
001295	NDDF
004938	NDDF
126112002	SNOMEDCT_US
126113007	SNOMEDCT_US
36621009	SNOMEDCT_US
D017258	MESH_DESCRIPTOR_UI
520-85-4	SECONDARY_CAS_RN

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Provera	HUMAN PRESCRIPTION DRUG LABEL	1	0009-0050	TABLET	10 mg	ORAL	NDA	25 sections
Provera	HUMAN PRESCRIPTION DRUG LABEL	1	0009-0051	TABLET	10 mg	ORAL	NDA	25 sections
Provera	HUMAN PRESCRIPTION DRUG LABEL	1	0009-0064	TABLET	2.50 mg	ORAL	NDA	25 sections
Provera	HUMAN PRESCRIPTION DRUG LABEL	1	0009-0065	TABLET	2.50 mg	ORAL	NDA	25 sections
Provera	HUMAN PRESCRIPTION DRUG LABEL	1	0009-0286	TABLET	5 mg	ORAL	NDA	25 sections
Provera	HUMAN PRESCRIPTION DRUG LABEL	1	0009-0287	TABLET	5 mg	ORAL	NDA	25 sections
Depo-Provera	HUMAN PRESCRIPTION DRUG LABEL	1	0009-0746	INJECTION, SUSPENSION	150 mg	INTRAMUSCULAR	NDA	29 sections
Depo-SubQ Provera	HUMAN PRESCRIPTION DRUG LABEL	1	0009-4709	INJECTION, SUSPENSION	104 mg	SUBCUTANEOUS	NDA	30 sections
Depo-Provera	HUMAN PRESCRIPTION DRUG LABEL	1	0009-7376	INJECTION, SUSPENSION	150 mg	INTRAMUSCULAR	NDA	29 sections
Prempro	HUMAN PRESCRIPTION DRUG LABEL	2	0046-1105	TABLET, SUGAR COATED	1.50 mg	ORAL	NDA	30 sections
Prempro	HUMAN PRESCRIPTION DRUG LABEL	2	0046-1105	TABLET, SUGAR COATED	1.50 mg	ORAL	NDA	30 sections
Prempro	HUMAN PRESCRIPTION DRUG LABEL	2	0046-1106	TABLET, SUGAR COATED	1.50 mg	ORAL	NDA	30 sections
Prempro	HUMAN PRESCRIPTION DRUG LABEL	2	0046-1106	TABLET, SUGAR COATED	1.50 mg	ORAL	NDA	30 sections
Prempro	HUMAN PRESCRIPTION DRUG LABEL	2	0046-1107	TABLET, SUGAR COATED	2.50 mg	ORAL	NDA	30 sections
Prempro	HUMAN PRESCRIPTION DRUG LABEL	2	0046-1107	TABLET, SUGAR COATED	2.50 mg	ORAL	NDA	30 sections
Prempro	HUMAN PRESCRIPTION DRUG LABEL	2	0046-1108	TABLET, SUGAR COATED	5 mg	ORAL	NDA	30 sections
Prempro	HUMAN PRESCRIPTION DRUG LABEL	2	0046-1108	TABLET, SUGAR COATED	5 mg	ORAL	NDA	30 sections
Medroxyprogesterone Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	0548-5400	INJECTION, SUSPENSION, EXTENDED RELEASE	150 mg	INTRAMUSCULAR	ANDA	29 sections
Medroxyprogesterone Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	0548-5410	INJECTION, SUSPENSION, EXTENDED RELEASE	150 mg	INTRAMUSCULAR	ANDA	29 sections
Medroxyprogesterone Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	0548-5410	INJECTION, SUSPENSION, EXTENDED RELEASE	150 mg	INTRAMUSCULAR	ANDA	29 sections
Medroxyprogesterone Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	0548-5701	INJECTION, SUSPENSION, EXTENDED RELEASE	150 mg	INTRAMUSCULAR	ANDA	29 sections
Medroxyprogesterone Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	0548-5711	INJECTION, SUSPENSION, EXTENDED RELEASE	150 mg	INTRAMUSCULAR	ANDA	29 sections
Medroxyprogesterone Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	0548-5711	INJECTION, SUSPENSION, EXTENDED RELEASE	150 mg	INTRAMUSCULAR	ANDA	29 sections
Medroxyprogesterone Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	0555-0779	TABLET	10 mg	ORAL	ANDA	24 sections
Medroxyprogesterone Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	0555-0872	TABLET	2.50 mg	ORAL	ANDA	24 sections
Medroxyprogesterone Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	0555-0873	TABLET	5 mg	ORAL	ANDA	24 sections
Medroxyprogesterone Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	0703-6801	INJECTION, SUSPENSION	150 mg	INTRAMUSCULAR	ANDA	29 sections
Medroxyprogesterone Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	0703-6801	INJECTION, SUSPENSION	150 mg	INTRAMUSCULAR	ANDA	29 sections
Medroxyprogesterone Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	10544-001	TABLET	5 mg	ORAL	ANDA	24 sections
Medroxyprogesterone Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	10544-062	TABLET	10 mg	ORAL	ANDA	24 sections