Stem definition | Drug id | CAS RN |
---|---|---|
1646 | 60-40-2 |
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 0 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 212 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 1.75 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 99 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
March 1, 1956 | FDA |
None
None
None
None
Source | Code | Description |
---|---|---|
ATC | C02BB01 | CARDIOVASCULAR SYSTEM ANTIHYPERTENSIVES ANTIADRENERGIC AGENTS, GANGLION-BLOCKING Secondary and tertiary amines |
MeSH PA | D000959 | Antihypertensive Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D018678 | Cholinergic Agents |
MeSH PA | D018680 | Cholinergic Antagonists |
MeSH PA | D005730 | Ganglionic Blockers |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D018733 | Nicotinic Antagonists |
MeSH PA | D018373 | Peripheral Nervous System Agents |
FDA EPC | N0000175641 | Autonomic Ganglionic Blocker |
FDA PE | N0000175644 | Decreased Autonomic Ganglionic Activity |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Hypertensive disorder | indication | 38341003 | DOID:10763 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 10.86 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Neuronal acetylcholine receptor; alpha3/beta4 | Ion channel | NEGATIVE ALLOSTERIC MODULATOR | Ki | 6.22 | WOMBAT-PK | CHEMBL | |||
Neuronal acetylcholine receptor; alpha2/beta4 | Ion channel | IC50 | 5.51 | CHEMBL | |||||
Neuronal acetylcholine receptor; alpha4/beta2 | Ion channel | Ki | 5.60 | WOMBAT-PK | |||||
Neuronal acetylcholine receptor; alpha3/beta2 | Ion channel | IC50 | 6.55 | CHEMBL | |||||
Neuronal acetylcholine receptor; alpha4/beta4 | Ion channel | BLOCKER | IC50 | 6.48 | IUPHAR | ||||
Neuronal acetylcholine receptor; alpha3/alpha6/beta2/beta3 | Ion channel | IC50 | 4.96 | CHEMBL | |||||
Acetylcholine receptor subunit alpha | Ion channel | BLOCKER | IC50 | 5.82 | IUPHAR | ||||
Neuronal acetylcholine receptor subunit alpha-3 | Ion channel | BLOCKER | IC50 | 6.41 | IUPHAR | ||||
Neuronal acetylcholine receptor subunit alpha-4 | Ion channel | BLOCKER | IC50 | 6.48 | IUPHAR | ||||
Neuronal acetylcholine receptor subunit alpha-7 | Ion channel | Ki | 5.16 | WOMBAT-PK | |||||
Neuronal acetylcholine receptor subunit alpha-6 | Ion channel | BLOCKER | IC50 | 4.96 | IUPHAR | ||||
Acetylcholine receptor subunit alpha | Ion channel | IC50 | 6.22 | CHEMBL |
ID | Source |
---|---|
4019807 | VUID |
N0000147896 | NUI |
D00611 | KEGG_DRUG |
826-39-1 | SECONDARY_CAS_RN |
4017929 | VANDF |
4019807 | VANDF |
C0025029 | UMLSCUI |
CHEBI:6706 | CHEBI |
CHEMBL267936 | ChEMBL_ID |
CHEMBL1398031 | ChEMBL_ID |
DB00657 | DRUGBANK_ID |
D008464 | MESH_DESCRIPTOR_UI |
4032 | PUBCHEM_CID |
542 | INN_ID |
3990 | IUPHAR_LIGAND_ID |
6EE945D3OK | UNII |
6673 | RXNORM |
5027 | MMSL |
d00739 | MMSL |
000655 | NDDF |
004499 | NDDF |
2991007 | SNOMEDCT_US |
372828008 | SNOMEDCT_US |
73277004 | SNOMEDCT_US |
CHEMBL1237082 | ChEMBL_ID |
6147-18-8 | SECONDARY_CAS_RN |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Mecamylamine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0722-7183 | TABLET | 2.50 mg | ORAL | ANDA | 19 sections |
Vecamyl | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45043-558 | TABLET | 2.50 mg | ORAL | ANDA | 19 sections |
Vecamyl | HUMAN PRESCRIPTION DRUG LABEL | 1 | 69413-558 | TABLET | 2.50 mg | ORAL | ANDA | 19 sections |
Vecamyl | HUMAN PRESCRIPTION DRUG LABEL | 1 | 69413-558 | TABLET | 2.50 mg | ORAL | ANDA | 19 sections |
Mecamylamine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 79739-7183 | TABLET | 2.50 mg | ORAL | ANDA | 19 sections |