mebhydrolin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	1643	524-81-2

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

fabahistin
mebhydrolin napadisilate
diazolinum
mebhydroline
mebhydrolin
mebhydrolin napadisylate

see also record for mebhydroline, RN: 524-81-2

Molecular weight: 276.38
Formula: C19H20N2
CLOGP: 4.01
LIPINSKI: 0
HAC: 2
HDO: 0
TPSA: 8.17
ALOGS: -3.88
ROTB: 2

Drug dosage:

Dose	Unit	Route
0.20	g	O

ADMET properties:

Property	Value	Reference
MRTD (Maximum Recommended Therapeutic Daily Dose)	15.51 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

Date	Agency	Company	Orphan
Jan. 1, 1954	YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	R06AX15	RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Other antihistamines for systemic use

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Allergic rhinitis	indication	61582004

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	7.31	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Histamine H1 receptor	GPCR	P35367	HRH1_HUMAN	ANTAGONIST	Ki	7.12		WOMBAT-PK	KEGG DRUG
Histamine H4 receptor	GPCR	Q9H3N8	HRH4_HUMAN					WOMBAT-PK
Muscarinic acetylcholine receptor M1	GPCR	P11229	ACM1_HUMAN		Ki	6.75		WOMBAT-PK
5-hydroxytryptamine receptor 5A	GPCR	P47898	5HT5A_HUMAN		Ki	6.92		WOMBAT-PK

External reference:

ID	Source
D01786	KEGG_DRUG
6153-33-9	SECONDARY_CAS_RN
CHEBI:135144	CHEBI
CHEMBL1625607	ChEMBL_ID
C025079	MESH_SUPPLEMENTAL_RECORD_UI
C005139	MESH_SUPPLEMENTAL_RECORD_UI
896	INN_ID
DB13808	DRUGBANK_ID
9SUK9B7XVY	UNII
22822	RXNORM
003997	NDDF
320747007	SNOMEDCT_US
419632002	SNOMEDCT_US
C0065834	UMLSCUI
22530	PUBCHEM_CID

Pharmaceutical products:

None