mebeverine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
spasmolytics with a papaverine-like action	1642	3625-06-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: mebeverine mebeverine hydrochloride CSAG 144 mebeverine HCl	Molecular weight: 429.56 Formula: C25H35NO5 CLOGP: 5.03 LIPINSKI: 1 HAC: 6 HDO: 0 TPSA: 57.23 ALOGS: -5.17 ROTB: 14

Molecule

Description

Molfile Inchi Smiles

Synonyms:

mebeverine
mebeverine hydrochloride
CSAG 144
mebeverine HCl

Molecular weight: 429.56
Formula: C25H35NO5
CLOGP: 5.03
LIPINSKI: 1
HAC: 6
HDO: 0
TPSA: 57.23
ALOGS: -5.17
ROTB: 14

Drug dosage:

Dose	Unit	Route
0.30	g	O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Catarrh	89.06	24.90	21	4572	1528	63482901
Steroid dependence	86.34	24.90	21	4572	1743	63482686
Accidental overdose	85.34	24.90	39	4554	23270	63461159
Burns second degree	83.96	24.90	21	4572	1957	63482472
Hypopnoea	70.34	24.90	21	4572	3785	63480644
Anxiety disorder	64.80	24.90	20	4573	4030	63480399
Tinnitus	64.28	24.90	37	4556	35591	63448838
Parosmia	56.42	24.90	20	4573	6186	63478243
Gingival pain	54.64	24.90	21	4572	8141	63476288
Bronchiectasis	49.78	24.90	24	4569	16118	63468311
Swollen tongue	49.44	24.90	31	4562	34769	63449660
Cardiac murmur	49.04	24.90	23	4570	14529	63469900
Rhinitis	47.91	24.90	21	4572	11345	63473084
Delirium	47.83	24.90	35	4558	50506	63433923
Vertigo	44.67	24.90	36	4557	59851	63424578
Impaired quality of life	44.04	24.90	21	4572	13762	63470667
Nightmare	43.01	24.90	23	4570	19171	63465258
Dermatitis atopic	41.09	24.90	18	4575	9706	63474723
Schizophrenia	40.69	24.90	18	4575	9934	63474495
Metastatic neoplasm	39.64	24.90	14	4579	4281	63480148
Tubulointerstitial nephritis	39.47	24.90	22	4571	19881	63464548
Impaired work ability	39.32	24.90	21	4572	17454	63466975
Vitamin D deficiency	37.89	24.90	19	4574	13873	63470556
Adjusted calcium decreased	36.65	24.90	7	4586	183	63484246
Frequent bowel movements	36.49	24.90	22	4571	23000	63461429
Rectal haemorrhage	35.55	24.90	29	4564	49001	63435428
Palpitations	35.11	24.90	42	4551	112728	63371701
Dyspepsia	35.04	24.90	40	4553	102156	63382273
Dysgeusia	34.65	24.90	28	4565	46682	63437747
Iron deficiency anaemia	34.04	24.90	20	4573	19949	63464480
Colitis ulcerative	33.96	24.90	22	4571	26069	63458360
Chest pain	33.90	24.90	58	4535	215901	63268528
Lip swelling	32.79	24.90	23	4570	31040	63453389
Splenic vein thrombosis	32.77	24.90	7	4586	324	63484105
Pulmonary embolism	32.36	24.90	41	4552	116643	63367786
Lagophthalmos	32.00	24.90	7	4586	363	63484066
Eczema	31.99	24.90	23	4570	32268	63452161
Somnolence	29.36	24.90	49	4544	178636	63305793
Lung neoplasm malignant	29.16	24.90	18	4575	19615	63464814
False positive investigation result	28.04	24.90	7	4586	646	63483783
Haemorrhoids	27.17	24.90	18	4575	22132	63462297
Angina pectoris	26.58	24.90	20	4573	30058	63454371
Migraine	25.05	24.90	34	4559	103312	63381117

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Nightmare	73.87	41.61	27	1589	14364	34940951
Gingival pain	69.52	41.61	18	1598	3034	34952281
Drug dispensed to wrong patient	56.36	41.61	11	1605	513	34954802
Swollen tongue	55.46	41.61	22	1594	14583	34940732
Burns second degree	53.35	41.61	12	1604	1117	34954198
Medication error	52.65	41.61	25	1591	25540	34929775
Steroid dependence	49.82	41.61	12	1604	1505	34953810
Catarrh	49.25	41.61	11	1605	991	34954324
Hypopnoea	44.92	41.61	12	1604	2277	34953038
Parosmia	44.24	41.61	12	1604	2413	34952902
Arthropod sting	44.14	41.61	9	1607	525	34954790

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Burns second degree	108.74	24.70	27	5393	2601	79736367
Steroid dependence	108.72	24.70	27	5393	2603	79736365
Catarrh	108.59	24.70	26	5394	2152	79736816
Gingival pain	99.32	24.70	33	5387	8965	79730003
Hypopnoea	89.84	24.70	27	5393	5302	79733666
Swollen tongue	87.10	24.70	47	5373	42523	79696445
Parosmia	86.59	24.70	28	5392	6986	79731982
Accidental overdose	84.62	24.70	45	5375	39536	79699432
Tinnitus	74.46	24.70	43	5377	44290	79694678
Cardiac murmur	67.69	24.70	29	5391	15795	79723173
Rhinitis	62.88	24.70	27	5393	14780	79724188
Nightmare	62.70	24.70	32	5388	25829	79713139
Bronchiectasis	61.04	24.70	30	5390	22356	79716612
Impaired quality of life	60.33	24.70	26	5394	14360	79724608
Vertigo	54.85	24.70	42	5378	69040	79669928
Medication error	52.90	24.70	41	5379	68601	79670367
Impaired work ability	49.59	24.70	25	5395	19656	79719312
Rectal haemorrhage	49.08	24.70	41	5379	76259	79662709
Drug dispensed to wrong patient	48.84	24.70	11	5409	695	79738273
Eczema	46.67	24.70	31	5389	40787	79698181
Frequent bowel movements	45.24	24.70	27	5393	29512	79709456
Palpitations	44.99	24.70	49	5371	126561	79612407
Dysgeusia	43.71	24.70	34	5386	57143	79681825
Lip swelling	41.84	24.70	29	5391	40882	79698086
Colitis ulcerative	41.21	24.70	27	5393	34715	79704253
Adverse drug reaction	39.26	24.70	34	5386	66358	79672610
Pulmonary embolism	39.04	24.70	53	5367	171601	79567367
Migraine	38.52	24.70	38	5382	87455	79651513
Myalgia	37.29	24.70	54	5366	185587	79553381
Tubulointerstitial nephritis	36.53	24.70	26	5394	38209	79700759
Adjusted calcium decreased	35.90	24.70	7	5413	218	79738750
Lagophthalmos	31.18	24.70	7	5413	436	79738532
Abdominal pain	27.71	24.70	73	5347	389496	79349472
Splenic vein thrombosis	26.98	24.70	7	5413	803	79738165
Dermatitis allergic	26.27	24.70	16	5404	18114	79720854
Pharyngeal swelling	26.10	24.70	12	5408	7707	79731261
Somnolence	26.05	24.70	53	5367	238928	79500040
Stress	25.15	24.70	29	5391	79583	79659385
Benign mediastinal neoplasm	24.80	24.70	4	5416	40	79738928
False positive investigation result	24.78	24.70	7	5413	1105	79737863

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A03AA04	ALIMENTARY TRACT AND METABOLISM DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS Synthetic anticholinergics, esters with tertiary amino group
MeSH PA	D000927	Anticonvulsants
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D010276	Parasympatholytics
MeSH PA	D018373	Peripheral Nervous System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Irritable bowel syndrome	indication	10743008	DOID:9778

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.31	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D04868	KEGG_DRUG
C0065832	UMLSCUI
CHEBI:91514	CHEBI
CHEMBL282121	ChEMBL_ID
DB12554	DRUGBANK_ID
C005096	MESH_SUPPLEMENTAL_RECORD_UI
4031	PUBCHEM_CID
9011	IUPHAR_LIGAND_ID
1191	INN_ID
2753-45-9	SECONDARY_CAS_RN
7F80CC3NNV	UNII
235827	RXNORM
003995	NDDF
003996	NDDF
349819003	SNOMEDCT_US
395779008	SNOMEDCT_US
419830007	SNOMEDCT_US
CHEMBL1446650	ChEMBL_ID

Pharmaceutical products:

None