mebeverine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
spasmolytics with a papaverine-like action	1642	3625-06-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: mebeverine mebeverine hydrochloride CSAG 144 mebeverine HCl	Molecular weight: 429.56 Formula: C25H35NO5 CLOGP: 5.03 LIPINSKI: 1 HAC: 6 HDO: 0 TPSA: 57.23 ALOGS: -5.17 ROTB: 14

Molecule

Description

Molfile Inchi Smiles

Synonyms:

mebeverine
mebeverine hydrochloride
CSAG 144
mebeverine HCl

Molecular weight: 429.56
Formula: C25H35NO5
CLOGP: 5.03
LIPINSKI: 1
HAC: 6
HDO: 0
TPSA: 57.23
ALOGS: -5.17
ROTB: 14

Drug dosage:

Dose	Unit	Route
0.30	g	O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Catarrh	89.06	24.90	21	4572	1528	63482901
Steroid dependence	86.34	24.90	21	4572	1743	63482686
Accidental overdose	85.34	24.90	39	4554	23270	63461159
Burns second degree	83.96	24.90	21	4572	1957	63482472
Hypopnoea	70.34	24.90	21	4572	3785	63480644
Anxiety disorder	64.80	24.90	20	4573	4030	63480399
Tinnitus	64.28	24.90	37	4556	35591	63448838
Parosmia	56.42	24.90	20	4573	6186	63478243
Gingival pain	54.64	24.90	21	4572	8141	63476288
Bronchiectasis	49.78	24.90	24	4569	16118	63468311

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Nightmare	73.87	41.61	27	1589	14364	34940951
Gingival pain	69.52	41.61	18	1598	3034	34952281
Drug dispensed to wrong patient	56.36	41.61	11	1605	513	34954802
Swollen tongue	55.46	41.61	22	1594	14583	34940732
Burns second degree	53.35	41.61	12	1604	1117	34954198
Medication error	52.65	41.61	25	1591	25540	34929775
Steroid dependence	49.82	41.61	12	1604	1505	34953810
Catarrh	49.25	41.61	11	1605	991	34954324
Hypopnoea	44.92	41.61	12	1604	2277	34953038
Parosmia	44.24	41.61	12	1604	2413	34952902

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Burns second degree	108.74	24.70	27	5393	2601	79736367
Steroid dependence	108.72	24.70	27	5393	2603	79736365
Catarrh	108.59	24.70	26	5394	2152	79736816
Gingival pain	99.32	24.70	33	5387	8965	79730003
Hypopnoea	89.84	24.70	27	5393	5302	79733666
Swollen tongue	87.10	24.70	47	5373	42523	79696445
Parosmia	86.59	24.70	28	5392	6986	79731982
Accidental overdose	84.62	24.70	45	5375	39536	79699432
Tinnitus	74.46	24.70	43	5377	44290	79694678
Cardiac murmur	67.69	24.70	29	5391	15795	79723173

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	A03AA04	ALIMENTARY TRACT AND METABOLISM DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS Synthetic anticholinergics, esters with tertiary amino group
MeSH PA	D000927	Anticonvulsants
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D010276	Parasympatholytics
MeSH PA	D018373	Peripheral Nervous System Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Irritable bowel syndrome	indication	10743008	DOID:9778

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.31	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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ID	Source
003995	NDDF
003996	NDDF
1191	INN_ID
235827	RXNORM
2753-45-9	SECONDARY_CAS_RN
349819003	SNOMEDCT_US
395779008	SNOMEDCT_US
4031	PUBCHEM_CID
419830007	SNOMEDCT_US
7F80CC3NNV	UNII

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Pharmaceutical products:

None