All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

mebeverine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
spasmolytics with a papaverine-like action	1642	3625-06-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: mebeverine mebeverine hydrochloride CSAG 144 mebeverine HCl	Molecular weight: 429.56 Formula: C25H35NO5 CLOGP: 5.03 LIPINSKI: 1 HAC: 6 HDO: 0 TPSA: 57.23 ALOGS: -5.17 ROTB: 14

Drug dosage:

Dose	Unit	Route
0.30	g	O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2A,ACVR2B,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK1,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPK9,MARK4,MET,MTOR,NTRK2,PAK4,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ZAP70	52
kinase-selectivity-class	AKT3,AXL,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,PDK4,PRKDC,SIK2,TEK,TTK	13
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Accidental overdose	100.77	24.64	45	5865	28228	90594309
Catarrh	90.10	24.64	21	5889	1613	90620924
Burns second degree	86.09	24.64	21	5889	1959	90620578
Steroid dependence	83.25	24.64	21	5889	2248	90620289
Anxiety disorder	75.62	24.64	23	5887	4899	90617638
Tinnitus	71.82	24.64	41	5869	43061	90579476
Hypopnoea	69.33	24.64	21	5889	4410	90618127
Parosmia	55.90	24.64	20	5890	7049	90615488
Gingival pain	53.32	24.64	21	5889	9631	90612906
Cardiac murmur	52.43	24.64	25	5885	18169	90604368
Swollen tongue	49.24	24.64	33	5877	45923	90576614
Nightmare	48.23	24.64	25	5885	21700	90600837
Vertigo	47.28	24.64	38	5872	69773	90552764
Vitamin D deficiency	47.19	24.64	23	5887	17533	90605004
Rhinitis	46.42	24.64	21	5889	13551	90608986
Myalgia	46.23	24.64	57	5853	175068	90447469
Dysgeusia	45.24	24.64	33	5877	52527	90570010
Bronchiectasis	44.75	24.64	24	5886	22306	90600231
Pulmonary embolism	43.58	24.64	48	5862	130772	90491765
Starvation ketoacidosis	42.43	24.64	8	5902	217	90622320
Palpitations	40.17	24.64	47	5863	136681	90485856
Metastatic neoplasm	39.49	24.64	14	5896	4801	90617736
Impaired work ability	39.37	24.64	21	5889	19305	90603232
Somnolence	38.33	24.64	57	5853	209027	90413510
Benign mediastinal neoplasm	38.22	24.64	6	5904	52	90622485
Mediastinal cyst	37.82	24.64	6	5904	56	90622481
Tubulointerstitial nephritis	36.64	24.64	22	5888	25321	90597216
Adjusted calcium decreased	36.10	24.64	7	5903	221	90622316
Impaired quality of life	35.83	24.64	21	5889	23123	90599414
Schizophrenia	35.53	24.64	18	5892	14896	90607641
Lip swelling	34.95	24.64	25	5885	38585	90583952
Eyelid sensory disorder	33.86	24.64	6	5904	114	90622423
Oesophageal irritation	33.29	24.64	7	5903	334	90622203
Iron deficiency anaemia	32.81	24.64	20	5890	23642	90598895
Angina pectoris	32.37	24.64	24	5886	39136	90583401
Splenic vein thrombosis	31.62	24.64	7	5903	426	90622111
Lagophthalmos	31.02	24.64	7	5903	465	90622072
Upper gastrointestinal haemorrhage	30.79	24.64	19	5891	22957	90599580
Pathological fracture	30.06	24.64	14	5896	9646	90612891
Eczema	30.02	24.64	26	5884	52844	90569693
Atrioventricular block complete	29.85	24.64	14	5896	9797	90612740
Dyspepsia	29.34	24.64	49	5861	198111	90424426
Delirium	29.19	24.64	35	5875	104324	90518213
Tooth deposit	28.75	24.64	6	5904	276	90622261
Haemorrhoids	28.17	24.64	19	5891	26683	90595854
Dermatitis atopic	27.92	24.64	18	5892	23454	90599083
False positive investigation result	27.41	24.64	7	5903	786	90621751
Lung neoplasm malignant	27.37	24.64	18	5892	24255	90598282
Suspected COVID-19	26.64	24.64	9	5901	2677	90619860
Chest pain	26.57	24.64	62	5848	319583	90302954
Rectal haemorrhage	25.21	24.64	29	5881	82715	90539822
Dermatitis allergic	24.94	24.64	15	5895	17312	90605225

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Gingival pain	286.77	71.43	84	5124	8410	42607717
Burns second degree	281.46	71.43	77	5131	6019	42610108
Catarrh	278.18	71.43	76	5132	5910	42610217
Steroid dependence	269.46	71.43	76	5132	6646	42609481
Parosmia	263.75	71.43	77	5131	7614	42608513
Hypopnoea	261.89	71.43	77	5131	7805	42608322
Systemic lupus erythematosus	249.12	71.43	77	5131	9247	42606880
Swollen tongue	239.67	71.43	92	5116	21139	42594988
Nightmare	228.47	71.43	93	5115	24919	42591208
Rhinitis	226.19	71.43	76	5132	11901	42604226
Cardiac murmur	225.29	71.43	77	5131	12698	42603429
Impaired work ability	213.68	71.43	73	5135	12018	42604109
Bronchiectasis	199.44	71.43	77	5131	17942	42598185
Frequent bowel movements	193.40	71.43	79	5129	21328	42594799
Medication error	187.63	71.43	88	5120	33066	42583061
Colitis ulcerative	181.32	71.43	80	5128	26095	42590032
Alcohol poisoning	179.10	71.43	57	5151	7517	42608610
Impaired quality of life	176.38	71.43	66	5142	14111	42602016
Migraine	173.85	71.43	77	5131	25337	42590790
Tinnitus	164.28	71.43	77	5131	28861	42587266
Eczema	164.12	71.43	81	5127	34005	42582122
Accidental overdose	159.64	71.43	75	5133	28255	42587872
Vertigo	154.67	71.43	78	5130	34269	42581858
Dysgeusia	149.15	71.43	76	5132	34113	42582014
Tubulointerstitial nephritis	148.98	71.43	74	5134	31474	42584653
Rectal haemorrhage	146.12	71.43	85	5123	49521	42566606
Stress	136.16	71.43	78	5130	44134	42571993
Arthritis	134.34	71.43	76	5132	41989	42574138
Loss of personal independence in daily activities	124.97	71.43	77	5131	49739	42566388
Palpitations	123.59	71.43	77	5131	50720	42565407
Haematochezia	120.95	71.43	80	5128	58356	42557771
Abdominal discomfort	107.12	71.43	82	5126	75173	42540954
Adverse drug reaction	104.51	71.43	62	5146	37372	42578755
Deep vein thrombosis	99.01	71.43	79	5129	76878	42539249
Intentional product use issue	97.26	71.43	76	5132	71757	42544370
Inappropriate schedule of product administration	83.91	71.43	79	5129	95823	42520304
Cerebrovascular accident	81.13	71.43	78	5130	97082	42519045
Depression	77.54	71.43	81	5127	111282	42504845
Pulmonary embolism	74.47	71.43	82	5126	119530	42496597

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Burns second degree	363.99	27.94	93	9793	7640	110571773
Catarrh	363.91	27.94	92	9794	7243	110572170
Steroid dependence	350.79	27.94	92	9794	8377	110571036
Hypopnoea	328.38	27.94	93	9793	11287	110568126
Gingival pain	324.02	27.94	99	9787	15637	110563776
Parosmia	319.27	27.94	94	9792	13086	110566327
Cardiac murmur	272.85	27.94	97	9789	24531	110554882
Rhinitis	261.96	27.94	92	9794	22453	110556960
Swollen tongue	258.28	27.94	120	9766	60242	110519171
Accidental overdose	256.37	27.94	114	9772	51720	110527693
Nightmare	243.31	27.94	101	9785	38762	110540651
Tinnitus	236.38	27.94	113	9773	60427	110518986
Bronchiectasis	232.36	27.94	96	9790	36397	110543016
Impaired work ability	229.49	27.94	87	9799	26332	110553081
Impaired quality of life	201.42	27.94	82	9804	29935	110549478
Alcohol poisoning	195.25	27.94	59	9827	8961	110570452
Dysgeusia	195.07	27.94	104	9782	69881	110509532
Vertigo	192.55	27.94	111	9775	86759	110492654
Tubulointerstitial nephritis	180.98	27.94	91	9795	54193	110525220
Eczema	172.62	27.94	97	9789	72196	110507217
Frequent bowel movements	168.32	27.94	95	9791	71295	110508118
Colitis ulcerative	163.85	27.94	96	9790	77267	110502146
Medication error	158.06	27.94	105	9781	105261	110474152
Rectal haemorrhage	155.08	27.94	109	9777	119724	110459689
Palpitations	148.50	27.94	119	9767	159093	110420320
Stress	136.69	27.94	96	9790	105252	110474161
Haematochezia	133.24	27.94	98	9788	115426	110463987
Pulmonary embolism	130.99	27.94	126	9760	214348	110365065
Adverse drug reaction	118.23	27.94	88	9798	105471	110473942
Deep vein thrombosis	116.64	27.94	98	9788	139789	110439624
Migraine	110.76	27.94	104	9782	171548	110407865
Loss of personal independence in daily activities	102.78	27.94	94	9792	149926	110429487
Arthritis	97.64	27.94	96	9790	167490	110411923
Somnolence	97.12	27.94	126	9760	297323	110282090
Inappropriate schedule of product administration	95.83	27.94	104	9782	203533	110375880
Cerebrovascular accident	91.31	27.94	96	9790	181188	110398225
Confusional state	74.97	27.94	143	9743	468537	110110876
Depression	69.15	27.94	111	9775	317224	110262189
COVID-19	65.08	27.94	94	9792	244966	110334447
Intentional product use issue	62.80	27.94	93	9793	247813	110331600
Systemic lupus erythematosus	60.99	27.94	93	9793	254245	110325168
Pain in extremity	51.76	27.94	126	9760	486992	110092421
Myalgia	50.06	27.94	79	9807	222302	110357111
Abdominal discomfort	46.29	27.94	106	9780	393752	110185661
Drug dispensed to wrong patient	45.19	27.94	11	9875	738	110578675
Lip swelling	43.21	27.94	36	9850	50631	110528782
Headache	36.78	27.94	166	9720	882211	109697202
Pharyngeal swelling	36.65	27.94	19	9867	12013	110567400
Benign mediastinal neoplasm	36.33	27.94	6	9880	52	110579361
Weight decreased	35.52	27.94	107	9779	467950	110111463
Mediastinal cyst	35.47	27.94	6	9880	61	110579352
Adjusted calcium decreased	33.06	27.94	7	9879	250	110579163
Eyelid sensory disorder	32.83	27.94	6	9880	98	110579315
Pneumonia	31.23	27.94	20	9866	876694	109702719

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A03AA04	ALIMENTARY TRACT AND METABOLISM DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS Synthetic anticholinergics, esters with tertiary amino group
MeSH PA	D000927	Anticonvulsants
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D010276	Parasympatholytics
MeSH PA	D018373	Peripheral Nervous System Agents
CHEBI has role	CHEBI:53784	antispasmodic drug

Related Drugs by ATC class:

A03AA Synthetic anticholinergics, esters with tertiary amino group 8 drugs

camylofindicycloverinedifemerinedihexyverineoxyphencycliminepiperidolaterociverinetrimebutine

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Irritable bowel syndrome	indication	10743008	DOID:9778

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.31	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D04868	KEGG_DRUG
C0065832	UMLSCUI
CHEBI:748080	CHEBI
CHEMBL282121	ChEMBL_ID
CHEMBL1446650	ChEMBL_ID
DB12554	DRUGBANK_ID
C005096	MESH_SUPPLEMENTAL_RECORD_UI
4031	PUBCHEM_CID
9011	IUPHAR_LIGAND_ID
1191	INN_ID
2753-45-9	SECONDARY_CAS_RN
7F80CC3NNV	UNII
235827	RXNORM
003995	NDDF
003996	NDDF
349819003	SNOMEDCT_US
395779008	SNOMEDCT_US
419830007	SNOMEDCT_US

Pharmaceutical products:

None