All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

masoprocol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	1637	27686-84-6

Description:

Molecule

Description

Molfile Inchi Smiles Synonyms: nordihydroguaiaretic acid masoprocol actinex mesonordihydroguaiaretic acid

A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in fats and oils. Molecular weight: 302.37 Formula: C18H22O4 CLOGP: 3.92 LIPINSKI: 0 HAC: 4 HDO: 4 TPSA: 80.92 ALOGS: -4.35 ROTB: 5 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,ALK,AURKA,AURKC,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK2,CDK4,CDK5,CDK9,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FGFR1,FLT1,FLT3,GRK2,GRK3,GSK3B,IGF1R,ITK,JAK1,JAK2,JAK3,KDR,KIT,MAP2K6,MAP3K1,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK1,MAPK10,MAPK12,MAPK14,MAPK7,MAPK8,MAPK9,MAPKAPK2,MARK4,MELK,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIM2,PLK1,PRKCD,PRKDC,PTK2,SGK1,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2,ZAP70	81
kinase-selectivity-class	ACVR2A,ACVR2B,ACVRL1,AXL,BMX,BRAF,CAMK2B,CAMK2D,CDK4,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,JAK2,KIT,MAP2K6,MAP3K14,MAPK1,MAPK12,MAPK7,MAPK8,MARK4,PIK3CD,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,ULK1	33
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

Date	Agency	Company	Orphan
Sept. 4, 1992	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	L01XX10	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS OTHER ANTINEOPLASTIC AGENTS Other antineoplastic agents
MeSH PA	D000700	Analgesics
MeSH PA	D000893	Anti-Inflammatory Agents
MeSH PA	D000894	Anti-Inflammatory Agents, Non-Steroidal
MeSH PA	D000975	Antioxidants
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D016859	Lipoxygenase Inhibitors
MeSH PA	D016861	Cyclooxygenase Inhibitors
MeSH PA	D018501	Antirheumatic Agents
MeSH PA	D018689	Sensory System Agents
MeSH PA	D018712	Analgesics, Non-Narcotic
MeSH PA	D020011	Protective Agents
CHEBI has role	CHEBI:22586	antioxidant
CHEBI has role	CHEBI:76924	plant metabolite
CHEBI has role	CHEBI:173084	ferroptosis inhibitor
CHEBI has role	CHEBI:176497	geroprotector
CHEBI has role	CHEBI:25212	metabolite
CHEBI has role	CHEBI:35526	hypoglycemic agent
CHEBI has role	CHEBI:35610	antineoplastic agent
CHEBI has role	CHEBI:35856	lipoxygenase inhibitor

Related Drugs by ATC class:

L01XX Other antineoplastic agents 33 drugs

adagrasibafliberceptaltretamineamsacrineanagrelidearsenic trioxideasparaginasebelzutifancalaspargase pegolcelecoxibdarinaparsindenileukin diftitox show all 33 →

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Actinic keratosis	indication	201101007	DOID:8866

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.09	acidic
pKa2	9.69	acidic
pKa3	13.33	acidic
pKa4	13.93	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Transthyretin	Secreted	P02766	TTHY_HUMAN		EC50	5.14		CHEMBL
Estrogen receptor	Nuclear hormone receptor	P03372	ESR1_HUMAN		IC50	4.65		CHEMBL
Androgen receptor	Nuclear hormone receptor	P10275	ANDR_HUMAN		IC50	4.41		CHEMBL
Aromatase	Enzyme	P11511	CP19A_HUMAN		IC50	7.96		CHEMBL
Arachidonate 5-lipoxygenase	Enzyme	P09917	LOX5_HUMAN		IC50	7.60		CHEMBL
Insulin-like growth factor 1 receptor	Kinase	P08069	IGF1R_HUMAN		IC50	6.05		CHEMBL
Arachidonate 15-lipoxygenase	Enzyme	P16050	LOX15_HUMAN		IC50	6.96		CHEMBL
Estradiol 17-beta-dehydrogenase 1	Enzyme	P14061	DHB1_HUMAN		IC50	5.26		CHEMBL
Estradiol 17-beta-dehydrogenase 2	Enzyme	P37059	DHB2_HUMAN		IC50	6.42		CHEMBL
Arachidonate 12-lipoxygenase, 12S-type	Enzyme	P18054	LOX12_HUMAN		IC50	6.96		CHEMBL
Leukotriene B4 receptor 1	GPCR	Q15722	LT4R1_HUMAN		IC50	7.07		CHEMBL
Transient receptor potential cation channel subfamily A member 1	Ion channel	O75762	TRPA1_HUMAN		EC50	5.31		CHEMBL
Arachidonate 15-lipoxygenase, type II	Enzyme	O15296	LX15B_HUMAN		IC50	4.96		CHEMBL
Alpha-synuclein	Transporter	P37840	SYUA_HUMAN		IC50	6.68		CHEMBL
Arachidonate 15-lipoxygenase	Enzyme		LOX15_RABIT		IC50	6.96		CHEMBL
Arachidonate 5-lipoxygenase	Enzyme		LOX5_RAT		IC50	8		CHEMBL
Seed linoleate 13S-lipoxygenase-1	Enzyme		LOX1_SOYBN		IC50	6.74		CHEMBL
Prostaglandin G/H synthase 1	Enzyme		PGH1_BOVIN		IC50	4.30		CHEMBL
Zinc finger protein mex-5	Cytosolic other		MEX5_CAEEL		EC50	5.06		CHEMBL
5-lipoxygenase	Enzyme		Q9BEG3_BOVIN		IC50	6.40		CHEMBL
Arachidonate 5-lipoxygenase	Enzyme		LOX5_MOUSE		IC50	6.40		CHEMBL
Cyclooxygenase	Enzyme		PGH1_BOVIN PGH2_BOVIN		IC50	4.85		CHEMBL
Lipoxygenase	Enzyme		Q39829_SOYBN		IC50	4.29		CHEMBL
Cytoplasmic zinc-finger protein	Cytosolic other		G5EF15_CAEEL		EC50	4.58		CHEMBL
Fatty acid hydroperoxide lyase, chloroplastic	Enzyme		HPL_SOLLC		IC50	4.30		CHEMBL

External reference:

ID	Source
4020556	VUID
N0000179680	NUI
D04862	KEGG_DRUG
4020556	VANDF
C0733397	UMLSCUI
CHEBI:73468	CHEBI
CHEMBL313972	ChEMBL_ID
CHEMBL52	ChEMBL_ID
DB00179	DRUGBANK_ID
D009637	MESH_DESCRIPTOR_UI
71398	PUBCHEM_CID
6615	INN_ID
7BO8G1BYQU	UNII
227238	RXNORM
5024	MMSL
966	MMSL
004081	NDDF
108933006	SNOMEDCT_US
398929003	SNOMEDCT_US
7BO8G1BYQU	INXIGHT DRUGS

Pharmaceutical products:

None