mannomustine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antineoplastic, alkylating agents, (beta-chloroethyl)amine derivatives 1633 576-68-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • mannomustine
  • mannitol mustard
  • mannomustin
Nitrogen mustard derivative alkylating agent used as antineoplastic. It causes severe bone marrow depression and is a powerful vesicant.
  • Molecular weight: 305.20
  • Formula: C10H22Cl2N2O4
  • CLOGP: 0.10
  • LIPINSKI: 1
  • HAC: 6
  • HDO: 6
  • TPSA: 104.98
  • ALOGS: -0.75
  • ROTB: 11

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000477 Alkylating Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018906 Antineoplastic Agents, Alkylating
MeSH PA D009676 Noxae

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.19 acidic
pKa2 12.73 acidic
pKa3 7.52 Basic
pKa4 6.92 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
C0024738 UMLSCUI
CHEBI:135296 CHEBI
CHEMBL460283 ChEMBL_ID
D008357 MESH_DESCRIPTOR_UI
3033867 PUBCHEM_CID
759 INN_ID
E60VWA40D2 UNII

Pharmaceutical products:

None