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malathion 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| insecticides, anthelminthics, pesticides etc., phosphorous derivatives | 1626 | 121-75-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A wide spectrum aliphatic organophosphate insecticide widely used for both domestic and commercial agricultural purposes.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IGF1R,IKBKB,ITK,JAK1,JAK2,JAK3,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAPK1,MAPK10,MAPK7,MAPK8,MAPK9,MAPKAPK2,MARK4,MELK,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ZAP70 | 65 | |||
| kinase-selectivity-class | ACVR2B,AXL,BRAF,CDK9,DDR1,EPHB4,ERBB2,GRK2,MAP2K6,MAPK7,PRKDC,STK33,SYK,TEK,ZAP70 | 15 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Aug. 2, 1982 | FDA | TARO PHARMS NORTH |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Pregnancy with injectable contraceptive | 74.88 | 49.81 | 7 | 34 | 134 | 90628272 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Pregnancy with injectable contraceptive | 75.47 | 63.97 | 7 | 48 | 108 | 110589136 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | P03AX03 | ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ECTOPARASITICIDES, INCL. SCABICIDES, INSECTICIDES AND REPELLENTS ECTOPARASITICIDES, INCL. SCABICIDES Other ectoparasiticides, incl. scabicides |
| FDA MoA | N0000000177 | Cholinesterase Inhibitors |
| MeSH PA | D002800 | Cholinesterase Inhibitors |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D007306 | Insecticides |
| MeSH PA | D010575 | Pesticides |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018678 | Cholinergic Agents |
| CHEBI has role | CHEBI:33286 | agrochemical |
| CHEBI has role | CHEBI:35442 | antiparasitic agent |
| CHEBI has role | CHEBI:37733 | EC 3.1.1.8 (cholinesterase) inhibitor |
| CHEBI has role | CHEBI:38462 | EC 3.1.1.7 (acetylcholinesterase) inhibitor |
| CHEBI has role | CHEBI:38706 | pediculicide |
| CHEBI has role | CHEBI:73333 | scabicide |
| CHEBI has role | CHEBI:136644 | proinsecticide |
| FDA EPC | N0000175723 | Cholinesterase Inhibitor |
Related Drugs by ATC class:
P03AX Other ectoparasiticides, incl. scabicides 4 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Pediculosis capitis | indication | 81000006 | DOID:5501 |
| Skin irritation | contraindication | 367466007 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
|---|---|---|---|---|---|---|---|---|---|---|
| 0.5% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | OVIDE | TARO | N018613 | Aug. 2, 1982 | DISCN | LOTION | TOPICAL | 7560445 | Feb. 1, 2027 | TREATMENT OF PATIENTS INFECTED WITH PEDICULUS HUMANUS CAPITIS (HEAD LICE AND THEIR OVA) OF THE SCALP HAIR |
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Melatonin receptor type 1A | GPCR | Ki | 9.54 | PDSP | |||||
| Acetylcholinesterase | Enzyme | INHIBITOR | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4018435 | VUID |
| N0000146761 | NUI |
| D00534 | KEGG_DRUG |
| 4018435 | VANDF |
| C0024547 | UMLSCUI |
| CHEBI:6651 | CHEBI |
| CHEMBL1200468 | ChEMBL_ID |
| DB00772 | DRUGBANK_ID |
| D008294 | MESH_DESCRIPTOR_UI |
| 4004 | PUBCHEM_CID |
| U5N7SU872W | UNII |
| 6606 | RXNORM |
| 165167 | MMSL |
| 8231 | MMSL |
| 002995 | NDDF |
| 333071000 | SNOMEDCT_US |
| 87205003 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Ovide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-5293 | LOTION | 0.00 g | TOPICAL | ANDA | 21 sections |
| Malathion | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-5294 | LOTION | 0.00 g | TOPICAL | ANDA | 21 sections |