All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

dimethicone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	3152	9006-65-9

Description:

Molecule	Description
Synonyms: simethicone dimethicone Silicone Fluid 350 polydimethylsiloxane dimeticone dimethicone 410	A poly(dimethylsiloxane) which is a polymer of 200-350 units of dimethylsiloxane, along with added silica gel. It is used as an antiflatulent, surfactant, and ointment base. Molecular weight: Formula: C6H18Si2(C2H6O2Si)n CLOGP: 3.39 LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

Date	Agency	Company	Orphan
June 26, 1997	FDA	MCNEIL

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	351.25	9.35	23	276074	145035	90207315
Drug ineffective	349.50	9.35	2631	273466	1381667	88970683
Milk-alkali syndrome	341.06	9.35	133	275964	1140	90351210
Liver injury	310.68	9.35	1183	274914	169384	90182966
Psoriatic arthropathy	276.42	9.35	1401	274696	226934	90125416
Wheezing	265.59	9.35	1428	274669	236652	90115698
Toxicity to various agents	250.40	9.35	305	275792	287541	90064809
Rheumatic fever	245.81	9.35	1021	275076	152100	90200250
Joint range of motion decreased	214.99	9.35	901	275196	134742	90217608
Macular degeneration	213.34	9.35	401	275696	37569	90314781
Swollen joint count increased	206.27	9.35	776	275321	110430	90241920
Schizophrenia	196.68	9.35	235	275862	14679	90337671
Type 2 diabetes mellitus	186.05	9.35	1157	274940	202087	90150263
Product dose omission issue	173.80	9.35	395	275702	291292	90061058
Facet joint syndrome	163.31	9.35	663	275434	97726	90254624
Fibromyalgia	160.77	9.35	1128	274969	205141	90147209
Deep vein thrombosis postoperative	159.63	9.35	527	275570	70282	90282068
Adjustment disorder with depressed mood	152.53	9.35	449	275648	56304	90296046
Hypomania	151.21	9.35	160	275937	8737	90343613
Injury	150.75	9.35	1074	275023	196275	90156075
Dyspepsia	149.97	9.35	1076	275021	197084	90155266
Intentional overdose	140.31	9.35	55	276042	93779	90258571
Sciatica	139.76	9.35	646	275451	100736	90251614
Lip dry	139.70	9.35	644	275453	100311	90252039
Autoimmune disorder	139.36	9.35	532	275565	76212	90276138
Dislocation of vertebra	139.31	9.35	431	275666	55537	90296813
Injection site pain	137.71	9.35	197	275900	173502	90178848
Jaundice cholestatic	136.97	9.35	161	275936	9882	90342468
Grip strength decreased	132.15	9.35	596	275501	91980	90260370
Road traffic accident	124.94	9.35	653	275444	106973	90245377
Duodenal ulcer perforation	122.55	9.35	1119	274978	220169	90132181
Mobility decreased	121.65	9.35	1233	274864	249501	90102849
Helicobacter infection	121.04	9.35	1138	274959	225712	90126638
Blood cholesterol increased	120.38	9.35	1062	275035	206950	90145400
Oedema	120.28	9.35	1031	275066	199264	90153086
Wound infection	116.99	9.35	636	275461	105766	90246584
Peripheral venous disease	115.11	9.35	534	275563	83387	90268963
Neurologic neglect syndrome	109.49	9.35	135	275962	8712	90343638
Hypercholesterolaemia	108.86	9.35	600	275497	100292	90252058
Carotid artery thrombosis	108.13	9.35	136	275961	8956	90343394
Rheumatoid arthritis	108.12	9.35	1627	274470	360987	89991363
Hypocalcaemia	107.98	9.35	329	275768	42039	90310311
Death	103.97	9.35	890	275207	455661	89896689
Gastrooesophageal reflux disease	101.85	9.35	860	275237	165477	90186873
Myelosuppression	101.31	9.35	20	276077	53571	90298779
Vaginal flatulence	100.80	9.35	156	275941	12482	90339868
Adjustment disorder	98.77	9.35	134	275963	9508	90342842
Proctitis	98.24	9.35	171	275926	15088	90337262
Device expulsion	97.43	9.35	7	276090	40879	90311471
Gait inability	97.09	9.35	771	275326	145685	90206665
Injection site erythema	94.75	9.35	96	276001	98406	90253944
Lower limb fracture	94.69	9.35	510	275587	84503	90267847
Amnesia	90.78	9.35	604	275493	107901	90244449
Lupus vulgaris	89.87	9.35	322	275775	44737	90307613
Irritable bowel syndrome	89.75	9.35	997	275100	206451	90145899
Rheumatoid factor positive	89.48	9.35	857	275240	170793	90181557
Recalled product	87.78	9.35	54	276043	1334	90351016
Cholelithiasis	86.45	9.35	353	275744	52153	90300197
Folliculitis	83.83	9.35	972	275125	203381	90148969
Asthma-chronic obstructive pulmonary disease overlap syndrome	83.08	9.35	88	276009	4811	90347539
Pulmonary fibrosis	82.57	9.35	586	275511	106917	90245433
Frequent bowel movements	82.33	9.35	368	275729	56567	90295783
Delirium	81.99	9.35	572	275525	103787	90248563
Radiculopathy	81.91	9.35	177	275920	18328	90334022
X-ray abnormal	81.72	9.35	314	275783	45110	90307240
Drug interaction	81.71	9.35	500	275597	275953	90076397
Hyperhidrosis	79.96	9.35	186	275911	136119	90216231
Total lung capacity increased	79.54	9.35	87	276010	4934	90347416
Female genital tract fistula	79.20	9.35	171	275926	17697	90334653
Accidental exposure to product	77.63	9.35	17	276080	42349	90310001
Injection site swelling	77.22	9.35	43	276054	59796	90292554
Colitis ulcerative	77.20	9.35	376	275721	59890	90292460
Hypoaesthesia	74.80	9.35	1359	274738	312851	90039499
Personality disorder	74.38	9.35	135	275962	12309	90340041
Nasal oedema	74.38	9.35	96	276001	6488	90345862
Prescribed overdose	73.15	9.35	529	275568	97096	90255254
Chronic sinusitis	72.43	9.35	197	275900	23605	90328745
COVID-19	71.76	9.35	268	275829	168575	90183775
Breast cancer stage II	71.74	9.35	254	275843	35080	90317270
C-reactive protein	71.16	9.35	234	275863	31133	90321217
Gangrene	71.09	9.35	135	275962	12741	90339609
Angioedema	71.06	9.35	56	276041	64820	90287530
Prescribed underdose	69.77	9.35	429	275668	74590	90277760
Vomiting	69.26	9.35	2998	273099	785295	89567055
Nasal obstruction	69.18	9.35	60	276037	2552	90349798
Sleep disorder	69.17	9.35	914	275183	197116	90155234
Dry mouth	68.71	9.35	860	275237	183199	90169151
Obesity	68.58	9.35	553	275544	104954	90247396
Walking aid user	67.65	9.35	250	275847	35256	90317094
Injection site pruritus	66.19	9.35	41	276056	53793	90298557
Arterial occlusive disease	65.66	9.35	128	275969	12318	90340032
Suicidal ideation	65.47	9.35	77	276020	73778	90278572
Abdominal pain	65.15	9.35	1622	274475	394099	89958251
Pneumonia aspiration	64.84	9.35	272	275825	40668	90311682
C-reactive protein abnormal	63.35	9.35	630	275467	126799	90225551
Coordination abnormal	62.25	9.35	174	275923	21182	90331168
Vaginal discharge	62.16	9.35	164	275933	19300	90333050
Sleep disorder due to general medical condition, insomnia type	61.93	9.35	632	275465	128062	90224288
Stomatitis	61.51	9.35	1177	274920	273521	90078829
Herpes zoster	61.45	9.35	122	275975	94522	90257828
Pericarditis	61.34	9.35	1160	274937	268991	90083359
Suicide attempt	61.24	9.35	84	276013	75315	90277035
Nephrocalcinosis	60.79	9.35	41	276056	1191	90351159
Bursitis	60.73	9.35	641	275456	131013	90221337
Hemiplegia	59.80	9.35	144	275953	16016	90336334
Osteoarthritis	59.32	9.35	881	275216	194849	90157501
Retinitis	58.96	9.35	253	275844	38205	90314145
Wrong technique in product usage process	58.87	9.35	79	276018	71492	90280858
Drug ineffective for unapproved indication	58.52	9.35	70	276027	66574	90285776
Sensory loss	58.44	9.35	153	275944	17922	90334428
Therapy interrupted	56.47	9.35	42	276055	50066	90302284
Injection site bruising	56.22	9.35	46	276051	52261	90300089
Breast cancer stage III	56.17	9.35	445	275652	84002	90268348
Impaired healing	55.37	9.35	1012	275085	233187	90119163
Wound	55.36	9.35	1260	274837	301720	90050630
Seizure	54.50	9.35	259	275838	152370	90199980
Nicotine dependence	54.35	9.35	36	276061	1014	90351336
Decreased appetite	54.34	9.35	1517	274580	375023	89977327
Hip arthroplasty	53.14	9.35	406	275691	75802	90276548
Gastrointestinal procedural complication	53.09	9.35	27	276070	455	90351895
Colitis	52.97	9.35	380	275717	69562	90282788
Multiple sclerosis relapse	52.58	9.35	49	276048	52256	90300094
Hypotension	52.56	9.35	687	275410	324710	90027640
Hypercalcaemia	52.30	9.35	225	275872	34015	90318335
Drug resistance	52.30	9.35	14	276083	30435	90321915
Eating disorder	52.09	9.35	196	275901	27877	90324473
Sinus congestion	50.50	9.35	191	275906	27233	90325117
Abortion spontaneous	50.49	9.35	54	276043	54002	90298348
Joint dislocation	50.00	9.35	268	275829	44314	90308036
Throat clearing	49.71	9.35	60	276037	3787	90348563
Anti-cyclic citrullinated peptide antibody	49.64	9.35	189	275908	27032	90325318
Anaphylactic reaction	49.29	9.35	122	275975	87402	90264948
Disease progression	49.03	9.35	278	275819	156337	90196013
Skin haemorrhage	48.95	9.35	160	275937	21220	90331130
Asthma	48.66	9.35	1021	275076	241139	90111211
Affect lability	48.61	9.35	143	275954	17920	90334430
General physical health deterioration	48.55	9.35	1421	274676	353694	89998656
Myocardial infarction	48.49	9.35	163	275934	105809	90246541
Full blood count abnormal	48.07	9.35	230	275867	36367	90315983
Bradycardia	47.90	9.35	116	275981	83731	90268619
Motor dysfunction	47.76	9.35	148	275949	19082	90333268
Loss of consciousness	47.74	9.35	242	275855	139996	90212354
Inappropriate schedule of product administration	47.01	9.35	266	275831	149667	90202683
Muscle injury	46.64	9.35	777	275320	175877	90176473
Segmental diverticular colitis	45.98	9.35	18	276079	156	90352194
Therapy cessation	45.67	9.35	27	276070	36334	90316016
Neutropenia	45.66	9.35	451	275646	224453	90127897
Liver disorder	45.40	9.35	567	275530	120702	90231648
Ulcer haemorrhage	44.95	9.35	179	275918	26142	90326208
Psychotic disorder	44.50	9.35	201	275896	31029	90321321
Cardiac arrest	44.29	9.35	167	275930	104768	90247582
General symptom	44.23	9.35	121	275976	14547	90337803
Oedema peripheral	44.15	9.35	1063	275034	256852	90095498
Sputum purulent	44.01	9.35	35	276062	1317	90351033
Hand deformity	43.86	9.35	1198	274899	295164	90057186
Glossodynia	43.81	9.35	1287	274810	320492	90031858
Food allergy	43.22	9.35	12	276085	25466	90326884
Night sweats	43.16	9.35	590	275507	128176	90224174
Seronegative arthritis	43.14	9.35	138	275959	18096	90334254
Foetal death	43.02	9.35	6	276091	20717	90331633
Nasal polyps	42.48	9.35	99	275998	10781	90341569
Lactic acidosis	42.22	9.35	55	276042	50408	90301942
Rectal haemorrhage	42.04	9.35	411	275686	82333	90270017
Bone erosion	41.86	9.35	291	275806	52730	90299620
Respiratory tract congestion	41.77	9.35	180	275917	27230	90325120
Calcium ionised decreased	41.66	9.35	21	276076	347	90352003
Paraesthesia oral	41.60	9.35	199	275898	31460	90320890
Pedal pulse abnormal	41.59	9.35	18	276079	206	90352144
Alanine aminotransferase increased	41.55	9.35	202	275895	118136	90234214
Sarcoidosis	41.54	9.35	97	276000	10576	90341774
Diarrhoea	41.44	9.35	3359	272738	935831	89416519
Taste disorder	41.30	9.35	325	275772	61221	90291129
Intentional product misuse	40.20	9.35	139	275958	89465	90262885
Sneezing	40.16	9.35	189	275908	29680	90322670
Irritability	40.05	9.35	30	276067	35632	90316718
Knee arthroplasty	39.77	9.35	408	275689	82774	90269576
Hypophosphataemic osteomalacia	39.62	9.35	18	276079	233	90352117
Drug reaction with eosinophilia and systemic symptoms	39.62	9.35	43	276054	42715	90309635
Cardio-respiratory arrest	39.62	9.35	83	276014	63057	90289293
Multiple drug therapy	39.33	9.35	74	276023	6935	90345415
Lupus-like syndrome	39.10	9.35	269	275828	48577	90303773
Blister	38.92	9.35	1035	275062	253963	90098387
Vision blurred	38.88	9.35	188	275909	110105	90242245
No adverse event	38.88	9.35	94	276003	67888	90284462
Blood glucose increased	38.64	9.35	154	275943	95092	90257258
Hepatocellular injury	38.55	9.35	20	276077	28938	90323412
Feeling abnormal	37.98	9.35	326	275771	166909	90185441
Back pain	37.89	9.35	709	275388	316466	90035884
Foetal exposure during pregnancy	37.88	9.35	45	276052	42930	90309420
Blood calcium decreased	37.71	9.35	187	275910	29995	90322355
Weight decreased	37.61	9.35	1464	274633	378446	89973904
Exostosis	37.56	9.35	284	275813	52850	90299500
Rash	37.34	9.35	2014	274083	794086	89558264
Hypoparathyroidism	37.13	9.35	28	276069	973	90351377
Rheumatoid nodule	37.13	9.35	8	276089	20158	90332192
Confusional state	37.00	9.35	1483	274614	384722	89967628
Heart rate increased	36.65	9.35	198	275899	112704	90239646
Urticaria	36.55	9.35	1228	274869	311506	90040844
Tremor	36.41	9.35	295	275802	152878	90199472
Serotonin syndrome	36.34	9.35	37	276060	37850	90314500
Poisoning deliberate	36.11	9.35	4	276093	16482	90335868
Hepatic cirrhosis	36.05	9.35	322	275775	62931	90289419
Flushing	35.95	9.35	143	275954	88348	90264002
Respiratory tract infection	35.89	9.35	305	275792	58773	90293577
Inflammation	35.86	9.35	753	275344	177839	90174511
Pneumonia	35.77	9.35	2327	273770	635732	89716618
Oropharyngeal pain	35.76	9.35	205	275892	114982	90237368
Myositis	35.66	9.35	157	275940	23971	90328379
Immunodeficiency	35.27	9.35	48	276049	43186	90309164
Off label use	35.25	9.35	2886	273211	1099366	89252984
Hepatic function abnormal	35.20	9.35	54	276043	46234	90306116
Illness	34.88	9.35	130	275967	81839	90270511
Laryngitis	34.60	9.35	269	275828	50484	90301866
Systemic lupus erythematosus	33.59	9.35	1385	274712	360511	89991839
Oxygen saturation decreased	33.52	9.35	191	275906	107292	90245058
Drug eruption	33.48	9.35	35	276062	35372	90316978
Subcutaneous drug absorption impaired	33.41	9.35	104	275993	13441	90338909
Pemphigus	33.15	9.35	1263	274834	325601	90026749
Tinnitus	33.04	9.35	50	276047	43052	90309298
Muscular weakness	33.03	9.35	844	275253	205822	90146528
Muscle spasticity	32.21	9.35	201	275896	35121	90317229
Musculoskeletal disorder	32.14	9.35	13	276084	21756	90330594
Electrocardiogram QT prolonged	32.09	9.35	113	275984	72343	90280007
Amyloid arthropathy	31.77	9.35	32	276065	1648	90350702
Rib deformity	31.76	9.35	16	276081	264	90352086
Injection site rash	31.73	9.35	17	276080	24156	90328194
Surgery	31.67	9.35	55	276042	44832	90307518
Methaemoglobinaemia	31.24	9.35	49	276048	3966	90348384
Neuropathy peripheral	31.10	9.35	267	275830	136703	90215647
Blood bilirubin increased	31.09	9.35	233	275864	43237	90309113
Erythema	30.71	9.35	502	275595	228744	90123606
Spondylitis	30.59	9.35	104	275993	14074	90338276
Hepatic enzyme increased	30.44	9.35	1367	274730	359369	89992981
Skin ulcer	30.44	9.35	67	276030	50008	90302342
Metabolic acidosis	30.27	9.35	79	276018	55597	90296753
Burning sensation	30.13	9.35	96	276001	63356	90288994
Incorrect route of product administration	30.03	9.35	260	275837	50366	90301984
Arthralgia	30.02	9.35	2006	274091	776516	89575834
Cholestasis	29.92	9.35	40	276057	36259	90316091
Therapy partial responder	29.67	9.35	15	276082	22028	90330322
Sinus disorder	29.55	9.35	193	275904	34254	90318096
Oral candidiasis	29.42	9.35	197	275900	35258	90317092
Pruritus	29.41	9.35	1349	274748	540176	89812174
Impaired quality of life	29.33	9.35	17	276080	23127	90329223
Secondary immunodeficiency	28.86	9.35	34	276063	2092	90350258
Skin necrosis	28.70	9.35	8	276089	16933	90335417
Headache	28.59	9.35	2252	273845	860494	89491856
Liver function test abnormal	28.52	9.35	71	276026	50774	90301576
Product storage error	28.43	9.35	13	276084	20228	90332122
Device difficult to use	28.37	9.35	9	276088	17516	90334834
Acute kidney injury	28.30	9.35	751	275346	319636	90032714
Tetany	28.14	9.35	37	276060	2547	90349803
Neuroleptic malignant syndrome	27.77	9.35	6	276091	15090	90337260
Coronary artery disease	27.76	9.35	37	276060	33586	90318764
Rhabdomyolysis	27.66	9.35	73	276024	51183	90301167
Disability	27.25	9.35	215	275882	40530	90311820
Dyspnoea	27.14	9.35	2313	273784	878642	89473708
Incorrect dose administered	26.97	9.35	136	275961	78794	90273556
Salivary gland calculus	26.97	9.35	13	276084	194	90352156
Throat tightness	26.93	9.35	30	276067	29454	90322896
Speech disorder	26.89	9.35	62	276035	45523	90306827
Foot deformity	26.82	9.35	289	275808	59362	90292988
Hepatic cytolysis	26.58	9.35	33	276064	30883	90321467
Blindness	26.57	9.35	25	276072	26543	90325807
Exercise tolerance decreased	26.57	9.35	66	276031	7485	90344865
Withdrawal syndrome	26.54	9.35	18	276079	22506	90329844
Carbuncle	26.52	9.35	27	276070	1409	90350941
Renal impairment	26.46	9.35	200	275897	105221	90247129
Agranulocytosis	26.45	9.35	41	276056	34961	90317389
Eye irritation	26.45	9.35	39	276058	33939	90318411
Acute respiratory distress syndrome	26.41	9.35	29	276068	28657	90323693
Hypertension	26.39	9.35	1673	274424	455859	89896491
Feeding intolerance	26.27	9.35	23	276074	991	90351359
Disturbance in attention	26.26	9.35	66	276031	47043	90305307
Malignant neoplasm progression	26.24	9.35	204	275893	106666	90245684
Multiple organ dysfunction syndrome	26.15	9.35	113	275984	68223	90284127
Rhinorrhoea	26.14	9.35	396	275701	87920	90264430
Dermatitis atopic	26.03	9.35	20	276077	23452	90328898
Chest pain	26.03	9.35	1207	274890	318438	90033912
Lung disorder	26.00	9.35	619	275478	149264	90203086
Restlessness	25.90	9.35	43	276054	35677	90316673
Overdose	25.79	9.35	332	275765	157377	90194973
Aspartate aminotransferase increased	25.50	9.35	196	275901	102741	90249609
Drug withdrawal syndrome	25.40	9.35	30	276067	28693	90323657
Musculoskeletal stiffness	25.29	9.35	1125	274972	295407	90056943
Swollen tongue	25.14	9.35	65	276032	45891	90306459
Rash vesicular	25.09	9.35	116	275981	18081	90334269
Breast cancer	25.07	9.35	82	276015	53679	90298671
Arteriovenous fistula occlusion	24.92	9.35	15	276082	356	90351994
Epilepsy	24.87	9.35	370	275727	81836	90270514
Drug abuse	24.79	9.35	148	275949	82199	90270151
Brain oedema	24.68	9.35	11	276086	17374	90334976
Device dislocation	24.64	9.35	36	276061	31446	90320904
Calciphylaxis	24.62	9.35	40	276057	3336	90349014
Procedural pain	24.53	9.35	180	275917	33180	90319170
Adverse event	24.52	9.35	498	275599	116920	90235430
Metabolic alkalosis	24.46	9.35	41	276056	3508	90348842
Bronchopulmonary aspergillosis	24.38	9.35	3	276094	11395	90340955
Cardiotoxicity	24.35	9.35	3	276094	11386	90340964
Poisoning	24.31	9.35	8	276089	15209	90337141
Disease recurrence	24.04	9.35	49	276048	37604	90314746
Shunt stenosis	23.82	9.35	17	276080	542	90351808
Mood swings	23.79	9.35	17	276080	20685	90331665
Sopor	23.71	9.35	24	276073	24620	90327730
Epistaxis	23.56	9.35	157	275940	84968	90267382
Cardiac failure congestive	23.48	9.35	190	275907	98504	90253846
Blepharospasm	23.27	9.35	265	275832	55180	90297170
Injection site urticaria	23.15	9.35	13	276084	17998	90334352
Swelling face	23.04	9.35	149	275948	81203	90271147
Musculoskeletal pain	23.02	9.35	684	275413	170567	90181783
Fungal infection	22.83	9.35	61	276036	42600	90309750
Red blood cell sedimentation rate abnormal	22.80	9.35	24	276073	24180	90328170
Creatinine renal clearance increased	22.74	9.35	38	276059	3243	90349107
Injection site haemorrhage	22.54	9.35	32	276065	28286	90324064
Monoclonal immunoglobulin present	22.49	9.35	30	276067	2094	90350256
Hepatotoxicity	22.46	9.35	226	275871	45616	90306734
Pancytopenia	22.41	9.35	246	275851	120017	90232333
Therapeutic response shortened	22.34	9.35	22	276075	22857	90329493
Hypotonia	22.16	9.35	4	276093	11422	90340928
Heavy menstrual bleeding	22.13	9.35	18	276079	20512	90331838
Product prescribing error	22.13	9.35	36	276061	30109	90322241
C-reactive protein increased	22.13	9.35	716	275381	180673	90171677
Thrombocytopenia	22.08	9.35	476	275621	208249	90144101
Contusion	22.06	9.35	956	275141	250260	90102090
Device issue	21.94	9.35	35	276062	29502	90322848
Hemiparesis	21.88	9.35	169	275928	31650	90320700
Blood pressure fluctuation	21.73	9.35	84	276013	52329	90300021
Basal cell carcinoma	21.70	9.35	43	276054	33346	90319004
Rhinitis allergic	21.69	9.35	105	275992	16680	90335670
Acute hepatic failure	21.67	9.35	22	276075	22539	90329811
Gonorrhoea	21.64	9.35	10	276087	135	90352215
Memory impairment	21.64	9.35	769	275328	196475	90155875
Obstructive airways disorder	21.62	9.35	144	275953	25725	90326625
Cardiac murmur	21.52	9.35	111	275986	18083	90334267
Hypercalciuria	21.49	9.35	14	276083	383	90351967
Blood pressure inadequately controlled	21.48	9.35	54	276043	6170	90346180
Product preparation error	21.23	9.35	3	276094	10258	90342092
Drug dose omission by device	21.15	9.35	3	276094	10228	90342122
Stress	21.11	9.35	153	275944	81242	90271108
Labelled drug-drug interaction medication error	21.06	9.35	9	276088	14573	90337777
Back disorder	21.01	9.35	142	275955	25489	90326861
Eye pruritus	21.00	9.35	35	276062	28992	90323358
Amenorrhoea	20.88	9.35	5	276092	11717	90340633
Live birth	20.88	9.35	348	275749	78759	90273591
Migraine	20.81	9.35	742	275355	189650	90162700
Cardiac failure	20.80	9.35	223	275874	109273	90243077
Flatulence	20.78	9.35	205	275892	41162	90311188
Injection site warmth	20.63	9.35	14	276083	17501	90334849
Intentional product use issue	20.54	9.35	832	275265	216060	90136290
Mydriasis	20.53	9.35	10	276087	15002	90337348
Central nervous system lupus	20.53	9.35	23	276074	1340	90351010
Head banging	20.42	9.35	14	276083	418	90351932
Malaise	20.28	9.35	2060	274037	583926	89768424
Leukopenia	19.99	9.35	203	275894	100507	90251843
Agitation	19.98	9.35	121	275976	66977	90285373
Abdominal discomfort	19.81	9.35	1700	274397	475628	89876722
Sedation complication	19.78	9.35	103	275994	16841	90335509
Complication of device insertion	19.50	9.35	4	276093	10432	90341918
Respiratory failure	19.46	9.35	249	275848	118169	90234181
Abortion induced	19.43	9.35	6	276091	11882	90340468
Renal function test abnormal	19.42	9.35	57	276040	7134	90345216
Tendonitis	19.24	9.35	22	276075	21350	90331000
Vertigo	19.20	9.35	129	275968	69682	90282668
Interstitial lung disease	19.15	9.35	145	275952	76260	90276090
Product substitution issue	19.15	9.35	16	276081	17992	90334358
Constipation	19.14	9.35	1041	275056	279354	90072996
Dry eye	19.13	9.35	101	275996	57830	90294520
Treatment failure	19.01	9.35	745	275352	303183	90049167
Spinal fusion surgery	18.98	9.35	81	276016	12202	90340148
Blue toe syndrome	18.93	9.35	14	276083	472	90351878
Nightmare	18.88	9.35	23	276074	21702	90330648
Sleep apnoea syndrome	18.87	9.35	43	276054	31704	90320646
Bone marrow failure	18.86	9.35	44	276053	32177	90320173
Crohn's disease	18.79	9.35	44	276053	4807	90347543
Shock	18.76	9.35	37	276060	28741	90323609
Abdominal distension	18.75	9.35	526	275571	130075	90222275
Large intestine polyp	18.65	9.35	67	276030	9319	90343031
Anti-cyclic citrullinated peptide antibody positive	18.64	9.35	890	275207	235543	90116807
Epidermal necrosis	18.63	9.35	29	276068	2332	90350018
Hypothyroidism	18.46	9.35	91	276006	53036	90299314
Intermenstrual bleeding	18.39	9.35	3	276094	9220	90343130
Encephalopathy	18.26	9.35	76	276021	46368	90305982
Haematochezia	18.00	9.35	310	275787	70603	90281747
Blood pressure decreased	17.90	9.35	144	275953	74751	90277599
Arthropathy	17.89	9.35	1321	274776	364921	89987429
Hypophosphataemia	17.83	9.35	91	276006	14763	90337587
Pustular psoriasis	17.81	9.35	107	275990	18449	90333901
Acute myeloid leukaemia	17.78	9.35	22	276075	20618	90331732
Hypoglycaemia	17.77	9.35	132	275965	69716	90282634
Osteoporosis	17.77	9.35	402	275695	96129	90256221
Akathisia	17.59	9.35	6	276091	11153	90341197
Sleep disorder due to a general medical condition	17.52	9.35	211	275886	44527	90307823
Dehydration	17.52	9.35	742	275355	193705	90158645
Platelet count decreased	17.33	9.35	303	275794	136666	90215684
Post procedural diarrhoea	17.31	9.35	12	276085	365	90351985
Pharyngitis	17.27	9.35	25	276072	21922	90330428
Cerebral haemorrhage	17.26	9.35	51	276046	34471	90317879
Onychomadesis	17.17	9.35	215	275882	45783	90306567
Anaphylactic shock	17.08	9.35	45	276052	31572	90320778
Small intestinal obstruction	17.03	9.35	117	275980	21117	90331233
Hemianopia	17.02	9.35	26	276071	2056	90350294
Asphyxia	17.02	9.35	54	276043	7049	90345301
Tardive dyskinesia	17.02	9.35	6	276091	10924	90341426
Hepatic failure	16.90	9.35	63	276034	39665	90312685
Synovitis	16.90	9.35	1194	274903	328558	90023792
Neuralgia	16.89	9.35	45	276052	31455	90320895
Psychomotor hyperactivity	16.83	9.35	9	276088	12804	90339546
Unevaluable event	16.81	9.35	98	275999	54750	90297600
Lymph node palpable	16.74	9.35	8	276089	117	90352233
Cerebral infarction	16.65	9.35	35	276062	26561	90325789
Urinary tract infection	16.63	9.35	761	275336	304871	90047479
Inappropriate antidiuretic hormone secretion	16.58	9.35	21	276076	19484	90332866
Vaginal haemorrhage	16.52	9.35	45	276052	31226	90321124
Device malfunction	16.40	9.35	24	276073	20953	90331397
Myalgia	16.38	9.35	407	275690	174718	90177632
Intentional dose omission	16.34	9.35	18	276079	17765	90334585
Creatinine renal clearance decreased	16.28	9.35	106	275991	18793	90333557
Drug intolerance	16.25	9.35	1159	274938	446432	89905918
Altered state of consciousness	16.19	9.35	46	276051	31486	90320864
Gestational diabetes	16.15	9.35	6	276091	10576	90341774
Hallucination	16.14	9.35	126	275971	65833	90286517
Mucosal inflammation	16.09	9.35	106	275991	57519	90294831
Discoloured vomit	16.07	9.35	19	276078	1173	90351177
Tachypnoea	16.06	9.35	25	276072	21284	90331066
Deep vein thrombosis	16.06	9.35	190	275907	91430	90260920
Bronchospasm	15.90	9.35	24	276073	20685	90331665
Injection site induration	15.87	9.35	6	276091	10462	90341888
Swollen joint count	15.71	9.35	60	276037	8593	90343757
Body mass index abnormal	15.70	9.35	15	276082	724	90351626
Gait disturbance	15.64	9.35	956	275141	259540	90092810
Body height decreased	15.62	9.35	75	276022	11874	90340476
Premature delivery	15.51	9.35	63	276034	38699	90313651
Erythema multiforme	15.51	9.35	9	276088	12237	90340113
Dyskinesia	15.50	9.35	58	276039	36476	90315874
Ulcer	15.43	9.35	50	276047	32832	90319518
Disseminated cryptococcosis	15.19	9.35	15	276082	754	90351596
Paralysis	15.17	9.35	8	276089	11470	90340880
Adrenal insufficiency	15.11	9.35	44	276053	29877	90322473
Joint injury	15.10	9.35	50	276047	32614	90319736
Syncope	15.07	9.35	299	275798	132364	90219986
Decreased immune responsiveness	15.07	9.35	4	276093	8744	90343606
Stress fracture	15.06	9.35	59	276038	8552	90343798
Peripheral pulse decreased	15.03	9.35	6	276091	55	90352295
Joint stiffness	14.99	9.35	327	275770	77715	90274635
Throat irritation	14.93	9.35	87	276010	48608	90303742
Ankylosing spondylitis	14.81	9.35	11	276086	13122	90339228
Chronic fatigue syndrome	14.76	9.35	21	276076	1558	90350792
Pain	14.71	9.35	2743	273354	993598	89358752
Diplopia	14.67	9.35	42	276055	28672	90323678
Loose tooth	14.55	9.35	34	276063	3709	90348641
Onychomycosis	14.52	9.35	176	275921	37200	90315150
Discomfort	14.51	9.35	996	275101	273339	90079011
Fear of injection	14.46	9.35	4	276093	8511	90343839
Eosinophilic cellulitis	14.43	9.35	9	276088	228	90352122
Oral herpes	14.37	9.35	53	276044	33471	90318879
Impaired work ability	14.26	9.35	23	276074	19303	90333047
Tenosynovitis	14.23	9.35	14	276083	14553	90337797
Intentional self-injury	14.19	9.35	44	276053	29290	90323060
Apathy	14.15	9.35	8	276089	11032	90341318
Maternal exposure timing unspecified	14.14	9.35	117	275980	22366	90329984
Unintended pregnancy	14.12	9.35	3	276094	7634	90344716
Respiratory depression	14.06	9.35	16	276081	15559	90336791
Respiratory arrest	14.06	9.35	53	276044	33258	90319092
Deformity	13.97	9.35	10	276087	12160	90340190
Abdominal pain upper	13.97	9.35	1186	274911	331488	90020862
Ill-defined disorder	13.94	9.35	693	275404	184198	90168152
Sinusitis	13.92	9.35	1220	274877	341868	90010482
Injection site mass	13.89	9.35	29	276068	22061	90330289
Bronchial wall thickening	13.87	9.35	24	276073	2107	90350243
Urine calcium/creatinine ratio increased	13.87	9.35	7	276090	116	90352234
Aphasia	13.86	9.35	195	275902	42617	90309733
Cardiogenic shock	13.85	9.35	34	276063	24434	90327916
Circulatory collapse	13.79	9.35	35	276062	24869	90327481
Breast cancer female	13.76	9.35	15	276082	14871	90337479
Hyponatraemia	13.69	9.35	306	275791	133232	90219118
Haemorrhage	13.69	9.35	140	275957	69229	90283121
Product dose omission in error	13.68	9.35	26	276071	20477	90331873
Hyperphosphataemia	13.66	9.35	33	276064	3678	90348672
Pelvic pain	13.62	9.35	16	276081	15341	90337009
Lipid metabolism disorder	13.59	9.35	8	276089	182	90352168
Eye injury	13.57	9.35	68	276029	10952	90341398
Bacterial disease carrier	13.46	9.35	22	276075	1844	90350506
Congestive cardiomyopathy	13.37	9.35	3	276094	7351	90344999
Polyneuropathy	13.37	9.35	24	276073	19317	90333033
Arteriosclerosis coronary artery	13.08	9.35	61	276036	9542	90342808
Fracture	13.04	9.35	30	276067	22046	90330304
Nystagmus	13.04	9.35	3	276094	7224	90345126
Renal failure	12.93	9.35	302	275795	130705	90221645
Hypothalamo-pituitary disorder	12.92	9.35	24	276073	2228	90350122
Exposure during pregnancy	12.89	9.35	594	275503	237816	90114534
Bronchiectasis	12.89	9.35	114	275983	22216	90330134
Oncocytoma	12.80	9.35	4	276093	16	90352334
Atrioventricular block complete	12.73	9.35	7	276090	9804	90342546
Acquired haemophilia	12.73	9.35	16	276081	1053	90351297
Hysterectomy	12.68	9.35	10	276087	11574	90340776
Posterior reversible encephalopathy syndrome	12.68	9.35	31	276066	22308	90330042
Hyperparathyroidism secondary	12.67	9.35	21	276076	1780	90350570
Porphyria acute	12.66	9.35	96	276001	17879	90334471
Pneumothorax spontaneous	12.64	9.35	15	276082	930	90351420
Subarachnoid haemorrhage	12.57	9.35	22	276075	17882	90334468
Pulmonary pain	12.37	9.35	39	276058	5075	90347275
Gastroenteritis viral	12.36	9.35	49	276048	30306	90322044
Product label confusion	12.35	9.35	115	275982	22735	90329615
Nephroangiosclerosis	12.34	9.35	8	276089	217	90352133
Post transplant lymphoproliferative disorder	12.31	9.35	3	276094	6946	90345404
Hypomagnesaemia	12.30	9.35	164	275933	35424	90316926
Fibrosis	12.26	9.35	43	276054	5909	90346441
Noninfectious peritonitis	12.26	9.35	7	276090	150	90352200
Spinal cord injury lumbar	12.24	9.35	5	276092	49	90352301
Hypokinesia	12.24	9.35	18	276079	15679	90336671
Nodule	12.23	9.35	41	276056	26645	90325705
Aggression	12.21	9.35	41	276056	26627	90325723
Visual acuity reduced	12.13	9.35	34	276063	23376	90328974
Periarticular disorder	12.06	9.35	5	276092	51	90352299
Coagulopathy	11.94	9.35	34	276063	23255	90329095
Delayed graft function	11.94	9.35	18	276079	1407	90350943
Drug-induced liver injury	11.93	9.35	360	275737	89958	90262392
Tension headache	11.90	9.35	4	276093	7505	90344845
Poliomyelitis	11.89	9.35	5	276092	53	90352297
Gastroenteritis bacterial	11.78	9.35	10	276087	413	90351937
Sinus bradycardia	11.75	9.35	21	276076	16931	90335419
Anti-saccharomyces cerevisiae antibody test positive	11.73	9.35	5	276092	55	90352295
Hypervitaminosis	11.73	9.35	5	276092	55	90352295
Dissociation	11.70	9.35	3	276094	6712	90345638
Diverticulitis	11.68	9.35	85	276012	45102	90307248
Ocular hyperaemia	11.68	9.35	58	276039	33740	90318610
Pharyngeal swelling	11.64	9.35	8	276089	9936	90342414
Stevens-Johnson syndrome	11.59	9.35	48	276049	29328	90323022
Hyperparathyroidism	11.57	9.35	29	276068	3308	90349042
Fanconi syndrome	11.51	9.35	21	276076	1922	90350428
Dystonia	11.51	9.35	21	276076	16798	90335552
Pulmonary arterial hypertension	11.49	9.35	41	276056	26146	90326204
Lacrimation increased	11.46	9.35	43	276054	27019	90325331
Blood glucose decreased	11.44	9.35	35	276062	23394	90328956
Toxic skin eruption	11.43	9.35	19	276078	15755	90336595
Localised infection	11.37	9.35	58	276039	33504	90318846
Clostridium difficile colitis	11.37	9.35	128	275969	26578	90325772
Therapeutic product effect decreased	11.37	9.35	711	275386	276860	90075490
Gastrointestinal sounds abnormal	11.31	9.35	35	276062	4508	90347842
Lip swelling	11.30	9.35	70	276027	38540	90313810
Urinary retention	11.27	9.35	68	276029	37676	90314674
Pulmonary embolism	11.18	9.35	308	275789	130512	90221838
Caesarean section	11.17	9.35	25	276072	18552	90333798
Cold sweat	11.12	9.35	16	276081	14065	90338285
Mesenteric phlebosclerosis	11.11	9.35	3	276094	6	90352344
Gluten sensitivity	11.10	9.35	13	276084	795	90351555
Parkinsonism	11.09	9.35	16	276081	14049	90338301
Abdominal rigidity	11.09	9.35	24	276073	2488	90349862
Urinary incontinence	11.05	9.35	68	276029	37498	90314852
Blood parathyroid hormone increased	11.01	9.35	29	276068	3408	90348942
Appetite disorder	11.00	9.35	56	276041	9077	90343273
Low turnover osteopathy	10.98	9.35	33	276064	4185	90348165
Respiratory rate increased	10.93	9.35	20	276077	15981	90336369
Candida infection	10.90	9.35	60	276037	33997	90318353
Toxic epidermal necrolysis	10.87	9.35	149	275948	32379	90319971
Therapeutic reaction time decreased	10.85	9.35	30	276067	3628	90348722
Grip strength	10.81	9.35	55	276042	8910	90343440
Polyarthritis	10.79	9.35	25	276072	18325	90334025
Dry skin	10.77	9.35	196	275901	87877	90264473
Sensory disturbance	10.77	9.35	19	276078	15394	90336956
Drug use disorder	10.76	9.35	6	276091	8337	90344013
Pulmonary mass	10.75	9.35	48	276049	28724	90323626
Eczema	10.72	9.35	106	275991	52764	90299586
Neoplasm malignant	10.67	9.35	60	276037	33820	90318530
Eye disorder	10.66	9.35	45	276052	27345	90325005
Miosis	10.62	9.35	8	276089	9476	90342874
Parathyroid gland enlargement	10.61	9.35	4	276093	31	90352319
Congenital knee deformity	10.59	9.35	5	276092	71	90352279
Extrapyramidal disorder	10.59	9.35	21	276076	16282	90336068
Underdose	10.59	9.35	227	275870	53790	90298560
Nail disorder	10.56	9.35	245	275852	58822	90293528
Metastases to lymph nodes	10.56	9.35	12	276085	11677	90340673
Middle insomnia	10.52	9.35	22	276075	16729	90335621
Atrial septal defect	10.50	9.35	6	276091	8228	90344122
Haemoptysis	10.50	9.35	59	276038	33261	90319089
Anti-erythropoietin antibody positive	10.49	9.35	9	276088	377	90351973
Platelet count increased	10.30	9.35	31	276066	20828	90331522
Arrhythmia	10.30	9.35	81	276016	42251	90310099
Hypocalcaemic seizure	10.29	9.35	4	276093	34	90352316
Muscle spasms	10.26	9.35	896	275201	250987	90101363
Infusion related reaction	10.25	9.35	1434	274663	415346	89937004
Pain of skin	10.20	9.35	21	276076	16061	90336289
Viral infection	10.19	9.35	79	276018	41335	90311015
Cytomegalovirus infection	10.17	9.35	44	276053	26558	90325792
Intracranial pressure increased	10.17	9.35	4	276093	6807	90345543
Haematotoxicity	10.14	9.35	14	276083	12521	90339829
Facial paralysis	10.10	9.35	20	276077	15514	90336836
Anal erosion	10.09	9.35	4	276093	36	90352314
Lung neoplasm	10.09	9.35	44	276053	6691	90345659
Eye pain	10.06	9.35	86	276011	44082	90308268
Incorrect product administration duration	10.06	9.35	28	276069	19294	90333056
Epstein-Barr virus infection	10.04	9.35	10	276087	10334	90342016
Osteomalacia	10.03	9.35	13	276084	882	90351468
Catatonia	10.00	9.35	3	276094	6053	90346297
Skin laceration	9.99	9.35	43	276054	25992	90326358
Chronic kidney disease-mineral and bone disorder	9.98	9.35	6	276091	142	90352208
Tongue disorder	9.97	9.35	11	276086	10849	90341501
Anal incontinence	9.96	9.35	84	276013	16146	90336204
Disseminated intravascular coagulation	9.94	9.35	33	276064	21505	90330845
Therapeutic product effect incomplete	9.91	9.35	702	275395	193194	90159156
Shunt occlusion	9.87	9.35	12	276085	763	90351587
Dysphonia	9.87	9.35	134	275963	62950	90289400
Hypervitaminosis A	9.80	9.35	3	276094	11	90352339
Faecalith	9.80	9.35	3	276094	11	90352339
Drug effective for unapproved indication	9.77	9.35	6	276091	7912	90344438
Body temperature increased	9.77	9.35	88	276009	44622	90307728
Sepsis	9.72	9.35	448	275649	179366	90172984
Hypertriglyceridaemia	9.71	9.35	6	276091	7883	90344467
Polyglandular disorder	9.70	9.35	7	276090	227	90352123
Intestinal fibrosis	9.70	9.35	7	276090	227	90352123
Immune thrombocytopenia	9.70	9.35	16	276081	13310	90339040
Proctalgia	9.68	9.35	50	276047	8148	90344202
Atypical femur fracture	9.66	9.35	42	276055	6379	90345971
Maternal exposure during pregnancy	9.64	9.35	955	275142	359108	89993242
Nephrogenic systemic fibrosis	9.64	9.35	31	276066	4077	90348273
Joint destruction	9.63	9.35	16	276081	13271	90339079
Haemorrhoids	9.62	9.35	124	275973	26578	90325772
Blood pH increased	9.61	9.35	11	276086	656	90351694
Foot operation	9.57	9.35	8	276089	8993	90343357
Diabetic ketoacidosis	9.56	9.35	40	276057	24367	90327983
Cytomegalovirus infection reactivation	9.51	9.35	6	276091	7794	90344556
Jaundice	9.49	9.35	59	276038	32458	90319892
Jaundice acholuric	9.49	9.35	5	276092	91	90352259
Blood potassium increased	9.43	9.35	32	276065	20717	90331633
Mitral valve incompetence	9.40	9.35	36	276061	22488	90329862
Nerve injury	9.40	9.35	12	276085	11094	90341256
Gastrointestinal disorder	9.38	9.35	906	275191	255781	90096569

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Milk-alkali syndrome	346.16	10.25	104	83739	603	42536889
Drug ineffective	215.68	10.25	588	83255	629609	41907883
Pulmonary vasculitis	167.77	10.25	121	83722	6145	42531347
Neuritis	161.73	10.25	118	83725	6102	42531390
Respiratory symptom	157.09	10.25	148	83695	10958	42526534
Completed suicide	153.52	10.25	9	83834	96456	42441036
Diarrhoea	137.45	10.25	1446	82397	459403	42078089
Antineutrophil cytoplasmic antibody positive	127.75	10.25	89	83754	4276	42533216
Obstructive airways disorder	125.73	10.25	196	83647	24563	42512929
Neurological symptom	120.46	10.25	122	83721	9869	42527623
Eosinophilic granulomatosis with polyangiitis	118.14	10.25	113	83730	8525	42528967
Toxicity to various agents	111.58	10.25	174	83669	228962	42308530
Total lung capacity abnormal	105.90	10.25	80	83763	4363	42533129
Mycotic allergy	105.51	10.25	83	83760	4808	42532684
Mite allergy	105.35	10.25	84	83759	4962	42532530
Spirometry abnormal	103.90	10.25	84	83759	5062	42532430
Conjunctivitis allergic	101.77	10.25	88	83755	5823	42531669
Dust allergy	101.28	10.25	84	83759	5248	42532244
Hypercalcaemia	91.74	10.25	143	83700	17915	42519577
Pulmonary alveolar haemorrhage	86.20	10.25	125	83718	14691	42522801
Fractional exhaled nitric oxide increased	85.69	10.25	48	83795	1561	42535931
Drug abuse	82.63	10.25	52	83791	104719	42432773
Nodule	79.20	10.25	110	83733	12424	42525068
Arteriosclerosis coronary artery	78.79	10.25	136	83707	18541	42518951
Normochromic normocytic anaemia	77.10	10.25	92	83751	8939	42528553
Full blood count abnormal	77.00	10.25	177	83666	29699	42507793
Shunt stenosis	76.12	10.25	35	83808	742	42536750
Wheezing	72.53	10.25	255	83588	54526	42482966
Forced expiratory volume decreased	72.28	10.25	82	83761	7548	42529944
Sleep disorder due to a general medical condition	72.21	10.25	126	83717	17327	42520165
Blood mercury abnormal	70.76	10.25	25	83818	257	42537235
Pulmonary fibrosis	64.31	10.25	154	83689	26527	42510965
Vasculitis	63.73	10.25	123	83720	18271	42519221
Dehydration	58.68	10.25	478	83365	141289	42396203
Plantar fasciitis	57.55	10.25	48	83795	3022	42534470
Nasal polyps	55.76	10.25	52	83791	3799	42533693
Haemoptysis	55.27	10.25	208	83635	45959	42491533
Myoglobin blood increased	53.85	10.25	50	83793	3632	42533860
Hypothyroidism	52.01	10.25	160	83683	31924	42505568
Calciphylaxis	51.85	10.25	31	83812	1142	42536350
Sensation of foreign body	50.80	10.25	48	83795	3565	42533927
Hypocalcaemia	50.34	10.25	152	83691	30021	42507471
Product use in unapproved indication	49.46	10.25	191	83652	184265	42353227
Abdominal distension	49.04	10.25	274	83569	71461	42466031
Proctalgia	48.98	10.25	65	83778	7028	42530464
Lung disorder	48.59	10.25	205	83638	47718	42489774
Abdominal pain	47.05	10.25	577	83266	189894	42347598
Brain natriuretic peptide increased	46.69	10.25	62	83781	6708	42530784
Arteriosclerosis	45.71	10.25	106	83737	17883	42519609
Off label use	44.70	10.25	938	82905	637397	41900095
5-hydroxyindolacetic acid in urine increased	43.84	10.25	16	83827	182	42537310
Frequent bowel movements	43.68	10.25	116	83727	21291	42516201
Colitis ulcerative	42.86	10.25	131	83712	26044	42511448
Small intestinal obstruction	42.77	10.25	100	83743	16961	42520531
Capillaritis	42.11	10.25	35	83808	2193	42535299
Hyperparathyroidism secondary	41.33	10.25	32	83811	1810	42535682
Asthma	41.25	10.25	236	83607	62078	42475414
SARS-CoV-2 test negative	40.19	10.25	31	83812	1744	42535748
Chronic sinusitis	40.12	10.25	41	83802	3351	42534141
Anal inflammation	40.03	10.25	34	83809	2195	42535297
Pulmonary embolism	39.51	10.25	384	83459	119228	42418264
Loss of personal independence in daily activities	39.32	10.25	198	83645	49618	42487874
Low density lipoprotein decreased	39.12	10.25	27	83816	1277	42536215
Myocardial infarction	37.50	10.25	122	83721	123887	42413605
Treatment failure	37.13	10.25	41	83802	62583	42474909
Methaemoglobinaemia	36.96	10.25	51	83792	5723	42531769
Drug resistance	36.46	10.25	11	83832	34237	42503255
Death	36.32	10.25	681	83162	470504	42066988
Drug ineffective for unapproved indication	36.25	10.25	23	83820	46140	42491352
Productive cough	35.92	10.25	198	83645	51369	42486123
Thrombosis	35.68	10.25	244	83599	68267	42469225
Nephrogenic systemic fibrosis	35.52	10.25	39	83804	3462	42534030
Exostosis	34.95	10.25	49	83794	5582	42531910
Granulomatous pneumonitis	33.74	10.25	9	83834	31	42537461
Metabolic alkalosis	33.60	10.25	30	83813	2071	42535421
Suicide attempt	33.50	10.25	25	83818	46075	42491417
Hungry bone syndrome	32.99	10.25	13	83830	185	42537307
Shunt occlusion	32.55	10.25	22	83821	1005	42536487
Myelosuppression	31.99	10.25	20	83823	40441	42497051
Drug interaction	31.34	10.25	355	83488	266644	42270848
Colitis	31.22	10.25	177	83666	46395	42491097
Blood calcium increased	27.43	10.25	55	83788	8399	42529093
Hyperphosphataemia	27.07	10.25	71	83772	12933	42524559
Pouchitis	26.95	10.25	19	83824	930	42536562
Hepatic neoplasm	26.86	10.25	27	83816	2164	42535328
Oesophageal perforation	26.76	10.25	21	83822	1212	42536280
Intestinal obstruction	26.61	10.25	115	83728	27043	42510449
Hypophosphataemia	26.42	10.25	96	83747	20849	42516643
Ileus	26.10	10.25	90	83753	19049	42518443
Aggression	26.08	10.25	29	83814	44134	42493358
Hypoxia	26.02	10.25	230	83613	69556	42467936
Blood parathyroid hormone increased	25.95	10.25	25	83818	1902	42535590
Soft tissue mass	25.86	10.25	19	83824	993	42536499
Open reduction of fracture	25.18	10.25	9	83834	96	42537396
Suicidal ideation	24.91	10.25	35	83808	48126	42489366
Multimorbidity	24.86	10.25	18	83825	919	42536573
Foetal exposure during pregnancy	24.85	10.25	34	83809	47277	42490215
5-hydroxyindolacetic acid increased	24.23	10.25	9	83834	108	42537384
Carcinoid tumour of the small bowel	23.98	10.25	13	83830	396	42537096
Vascular device infection	23.84	10.25	43	83800	6067	42531425
Cutaneous T-cell lymphoma stage I	23.79	10.25	9	83834	114	42537378
Blood pressure diastolic increased	23.63	10.25	44	83799	6361	42531131
Haemorrhoids	22.97	10.25	80	83763	17017	42520475
Coma	22.96	10.25	44	83799	53510	42483982
Blood pressure systolic increased	22.65	10.25	112	83731	27856	42509636
Hypomagnesaemia	22.31	10.25	113	83730	28375	42509117
Contraindicated product administered	22.13	10.25	11	83832	25261	42512231
Therapeutic product effect decreased	21.73	10.25	27	83816	39123	42498369
Hyperparathyroidism	21.68	10.25	19	83824	1280	42536212
Blood follicle stimulating hormone increased	21.66	10.25	10	83833	214	42537278
Secretion discharge	21.64	10.25	47	83796	7588	42529904
Enterocolonic fistula	21.61	10.25	8	83835	95	42537397
Sedation	21.54	10.25	17	83826	30458	42507034
Calcinosis	21.53	10.25	16	83827	851	42536641
Intentional overdose	21.43	10.25	43	83800	51413	42486079
Wrong technique in product usage process	21.05	10.25	32	83811	42603	42494889
Growth hormone deficiency	20.84	10.25	11	83832	317	42537175
Therapeutic reaction time decreased	20.82	10.25	23	83820	2055	42535437
Atypical fracture	20.38	10.25	9	83834	173	42537319
Foreign body in throat	20.27	10.25	13	83830	543	42536949
Increased upper airway secretion	20.13	10.25	25	83818	2531	42534961
Fistula discharge	20.10	10.25	17	83826	1091	42536401
Crohn's disease	20.07	10.25	27	83816	2957	42534535
Red blood cell count decreased	19.77	10.25	121	83722	32594	42504898
Bone density decreased	19.70	10.25	23	83820	2183	42535309
Immunosuppressant drug level decreased	19.70	10.25	21	83822	1803	42535689
N-telopeptide urine increased	19.66	10.25	6	83837	37	42537455
Electrolyte imbalance	19.59	10.25	76	83767	17025	42520467
Nerve degeneration	19.35	10.25	9	83834	196	42537296
Interstitial lung disease	19.27	10.25	84	83759	78378	42459114
Enterocolitis bacterial	19.09	10.25	11	83832	378	42537114
Respiratory tract infection bacterial	18.91	10.25	21	83822	1888	42535604
Femur fracture	18.84	10.25	52	83791	9760	42527732
Transfusion-related circulatory overload	18.67	10.25	14	83829	755	42536737
Hypophosphatasia	18.65	10.25	6	83837	45	42537447
Synovitis	18.49	10.25	4	83839	15563	42521929
Expired product administered	18.46	10.25	31	83812	4132	42533360
Abscess intestinal	18.12	10.25	20	83823	1786	42535706
Drug hypersensitivity	17.97	10.25	118	83725	99271	42438221
Neuroleptic malignant syndrome	17.84	10.25	10	83833	21462	42516030
Hallucination	17.77	10.25	56	83787	57451	42480041
Anaphylactic reaction	17.56	10.25	36	83807	42707	42494785
Renal tubular dysfunction	17.51	10.25	11	83832	443	42537049
Blood potassium decreased	17.49	10.25	83	83760	20301	42517191
Gastrointestinal obstruction	17.44	10.25	16	83827	1144	42536348
Constipation	17.38	10.25	430	83413	161861	42375631
Pain in extremity	17.33	10.25	403	83440	150201	42387291
Clostridium difficile colitis	17.13	10.25	85	83758	21167	42516325
Poisoning	17.01	10.25	4	83839	14695	42522797
Flatulence	16.46	10.25	95	83748	25057	42512435
Lactic acidosis	16.26	10.25	41	83802	45220	42492272
Haematocrit decreased	16.23	10.25	121	83722	34787	42502705
Activated partial thromboplastin time prolonged	16.09	10.25	68	83775	15835	42521657
Blood immunoglobulin E increased	16.08	10.25	27	83816	3598	42533894
Accident at work	15.92	10.25	14	83829	947	42536545
Therapy non-responder	15.77	10.25	53	83790	53306	42484186
Agitation	15.70	10.25	69	83774	64245	42473247
Urogenital fistula	15.70	10.25	3	83840	0	42537492
Hypergastrinaemia	15.57	10.25	8	83835	218	42537274
Erythema	15.50	10.25	138	83705	108655	42428837
Respiratory depression	15.37	10.25	9	83834	18859	42518633
Primary familial brain calcification	15.37	10.25	5	83838	39	42537453
Central nervous system mass	15.32	10.25	13	83830	838	42536654
Gastrointestinal stoma output increased	15.29	10.25	10	83833	432	42537060
Wall motion score index abnormal	15.27	10.25	13	83830	842	42536650
Dyspnoea	14.77	10.25	1035	82808	441586	42095906
Airway remodelling	14.69	10.25	13	83830	887	42536605
Fibrous histiocytoma	14.68	10.25	9	83834	347	42537145
Respiratory tract infection viral	14.62	10.25	25	83818	3381	42534111
Haematopoietic stem cell mobilisation	14.54	10.25	9	83834	353	42537139
Bilirubin conjugated abnormal	14.26	10.25	6	83837	102	42537390
Angioedema	14.10	10.25	40	83803	42437	42495055
Psoriatic arthropathy	14.08	10.25	17	83826	24950	42512542
Rheumatoid arthritis	14.07	10.25	40	83803	42400	42495092
Hepatic function abnormal	14.05	10.25	53	83790	51514	42485978
Cardiac septal defect	13.97	10.25	13	83830	947	42536545
Hypovolaemia	13.95	10.25	52	83791	11433	42526059
Psoriasis	13.87	10.25	49	83794	48555	42488937
Atopy	13.80	10.25	13	83830	962	42536530
Bronchial obstruction	13.76	10.25	17	83826	1712	42535780
Neoplasm	13.72	10.25	35	83808	6270	42531222
SARS-CoV-2 antibody test positive	13.64	10.25	9	83834	395	42537097
Weight decreased	13.44	10.25	518	83325	207430	42330062
Pleural effusion	13.42	10.25	267	83576	96899	42440593
Psychotic disorder	13.41	10.25	23	83820	29185	42508307
Injection site erythema	13.37	10.25	12	83831	20183	42517309
Disturbance in attention	13.27	10.25	24	83819	29842	42507650
Blood calcium decreased	13.24	10.25	50	83793	11058	42526434
End stage renal disease	13.19	10.25	66	83777	16492	42521000
Extrapyramidal disorder	13.13	10.25	8	83835	16404	42521088
Stoma complication	13.11	10.25	10	83833	553	42536939
Rectal prolapse	13.03	10.25	10	83833	558	42536934
Accident	13.02	10.25	35	83808	6468	42531024
Shunt aneurysm	12.80	10.25	4	83839	27	42537465
Monoclonal immunoglobulin increased	12.79	10.25	9	83834	439	42537053
Sleep disorder therapy	12.71	10.25	36	83807	6858	42530634
Failure to thrive	12.58	10.25	44	83799	9378	42528114
Product dose omission issue	12.48	10.25	221	83622	154144	42383348
Blood 25-hydroxycholecalciferol decreased	12.46	10.25	8	83835	335	42537157
Paranoia	12.44	10.25	6	83837	14020	42523472
Calcification metastatic	12.42	10.25	3	83840	6	42537486
Circulatory collapse	12.40	10.25	17	83826	23619	42513873
Overgrowth bacterial	12.37	10.25	6	83837	144	42537348
Dysphonia	12.32	10.25	97	83746	28353	42509139
Skin induration	12.30	10.25	17	83826	1910	42535582
Cardiac failure	12.14	10.25	143	83700	106713	42430779
Alkalosis	12.11	10.25	6	83837	151	42537341
Systemic inflammatory response syndrome	12.11	10.25	37	83806	7353	42530139
Intentional dose omission	12.03	10.25	42	83801	8944	42528548
Overdose	11.91	10.25	141	83702	105123	42432369
Haemoglobin decreased	11.88	10.25	343	83500	132128	42405364
Superinfection	11.81	10.25	21	83822	2930	42534562
Renal mass	11.80	10.25	17	83826	1985	42535507
Premature baby	11.80	10.25	17	83826	23136	42514356
Necrotising ulcerative gingivostomatitis	11.78	10.25	5	83838	87	42537405
Myocarditis	11.66	10.25	12	83831	18926	42518566
Gastroenteritis staphylococcal	11.61	10.25	7	83836	262	42537230
Peripheral motor neuropathy	11.59	10.25	18	83825	2246	42535246
Drug use disorder	11.59	10.25	3	83840	10330	42527162
Mixed dementia	11.49	10.25	7	83836	267	42537225
Dermatitis atopic	11.48	10.25	5	83838	12399	42525093
Hepatocellular injury	11.47	10.25	18	83825	23660	42513832
Blood test abnormal	11.40	10.25	53	83790	12853	42524639
Vomiting	11.36	10.25	687	83156	289036	42248456
Ulcer	11.35	10.25	63	83780	16378	42521114
Renal cyst haemorrhage	11.33	10.25	10	83833	680	42536812
Blood parathyroid hormone decreased	11.26	10.25	15	83828	1628	42535864
Poisoning deliberate	11.26	10.25	3	83840	10131	42527361
Hepatic enzyme increased	11.25	10.25	49	83794	45735	42491757
Blood phosphorus decreased	11.21	10.25	23	83820	3570	42533922
Disease progression	11.19	10.25	207	83636	143449	42394043
Erectile dysfunction	11.09	10.25	20	83823	24893	42512599
High turnover osteopathy	11.08	10.25	4	83839	44	42537448
Anal fistula	11.02	10.25	32	83811	6181	42531311
Device related infection	11.01	10.25	73	83770	20206	42517286
Microangiopathy	10.98	10.25	15	83828	1667	42535825
Therapy partial responder	10.91	10.25	14	83829	20007	42517485
Transurethral prostatectomy	10.82	10.25	8	83835	422	42537070
Respiratory arrest	10.80	10.25	25	83818	28399	42509093
Drug eruption	10.75	10.25	18	83825	23057	42514435
Chronic respiratory failure	10.71	10.25	15	83828	1707	42535785
Lung consolidation	10.54	10.25	33	83810	6644	42530848
Neuromyopathy	10.42	10.25	12	83831	1122	42536370
Ascites	10.41	10.25	163	83680	56515	42480977
Hepatic infection	10.39	10.25	10	83833	760	42536732
Autoimmune colitis	10.36	10.25	12	83831	1129	42536363
Pneumonia	10.32	10.25	964	82879	421185	42116307
Muscle swelling	10.28	10.25	8	83835	456	42537036
Puncture site pain	10.28	10.25	4	83839	55	42537437
Injection site pain	10.25	10.25	69	83774	57729	42479763

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Milk-alkali syndrome	651.67	9.60	234	299896	1771	110287398
Completed suicide	529.71	9.60	32	300098	242349	110046820
Drug ineffective	430.87	9.60	2400	297730	1518140	108771029
Toxicity to various agents	400.59	9.60	428	299702	480127	109809042
Wheezing	346.58	9.60	1492	298638	253738	110035431
Rheumatic fever	298.56	9.60	869	299261	121710	110167459
Swollen joint count increased	244.37	9.60	634	299496	83027	110206142
Psoriatic arthropathy	217.29	9.60	1083	299047	195678	110093491
Facet joint syndrome	215.48	9.60	665	299465	96163	110193006
Joint range of motion decreased	209.35	9.60	767	299363	121065	110168104
Lip dry	197.85	9.60	660	299470	99423	110189746
Liver injury	196.15	9.60	869	299261	149544	110139625
Type 2 diabetes mellitus	169.16	9.60	937	299193	176295	110112874
Intentional overdose	165.61	9.60	76	300054	132425	110156744
Duodenal ulcer perforation	164.64	9.60	932	299198	176768	110112401
Fibromyalgia	164.07	9.60	905	299225	170004	110119165
Sciatica	162.35	9.60	586	299544	91813	110197356
Schizophrenia	162.13	9.60	245	299885	21581	110267588
Myelosuppression	155.50	9.60	33	300097	94307	110194862
Death	155.15	9.60	1185	298945	697684	109591485
Deep vein thrombosis postoperative	153.69	9.60	430	299700	58861	110230308
Hypomania	153.57	9.60	163	299967	10047	110279122
Peripheral venous disease	152.51	9.60	539	299591	83578	110205591
Drug interaction	148.63	9.60	775	299355	499408	109789761
Helicobacter infection	148.62	9.60	923	299207	180954	110108215
Rheumatoid factor positive	139.95	9.60	717	299413	130923	110158246
Injury	133.37	9.60	881	299249	176384	110112785
Autoimmune disorder	130.43	9.60	433	299697	65050	110224119
Rheumatoid arthritis	130.19	9.60	1314	298816	298299	109990870
Product dose omission issue	129.94	9.60	443	299687	321339	109967830
Pulmonary vasculitis	128.71	9.60	121	300009	6439	110282730
Mobility decreased	127.16	9.60	1089	299041	236333	110052836
Full blood count abnormal	126.58	9.60	387	299743	55665	110233504
Neurologic neglect syndrome	121.73	9.60	138	299992	9160	110280009
Hypocalcaemia	120.34	9.60	421	299709	64945	110224224
Blood cholesterol increased	119.42	9.60	885	299245	183900	110105269
Road traffic accident	119.10	9.60	592	299538	106806	110182363
Frequent bowel movements	118.88	9.60	445	299685	70945	110218224
Hypercalcaemia	118.60	9.60	336	299794	46321	110242848
Carotid artery thrombosis	117.69	9.60	138	299992	9500	110279669
Gastrooesophageal reflux disease	116.89	9.60	863	299267	179113	110110056
Neuritis	116.42	9.60	121	300009	7278	110281891
Adjustment disorder with depressed mood	115.45	9.60	320	299810	43563	110245606
Chronic sinusitis	114.50	9.60	227	299903	24857	110264312
Jaundice cholestatic	112.82	9.60	167	299963	14441	110274728
Drug abuse	112.18	9.60	193	299937	177218	110111951
Myocardial infarction	109.94	9.60	222	299908	191861	110097308
Irritable bowel syndrome	109.84	9.60	793	299337	163422	110125747
Dyspepsia	109.21	9.60	889	299241	190076	110099093
Grip strength decreased	108.89	9.60	469	299661	79705	110209464
Pulmonary fibrosis	108.59	9.60	556	299574	101486	110187683
Folliculitis	107.79	9.60	802	299328	166851	110122318
Asthma	106.93	9.60	1094	299036	249197	110039972
Colitis ulcerative	105.41	9.60	453	299677	76910	110212259
Systemic lupus erythematosus	104.08	9.60	1102	299028	253236	110035933
Cholelithiasis	102.84	9.60	392	299738	63030	110226139
Nasal polyps	102.09	9.60	151	299979	13049	110276120
Dislocation of vertebra	101.66	9.60	305	299825	43416	110245753
Dry mouth	101.27	9.60	906	299224	199042	110090127
Injection site pain	100.66	9.60	207	299923	177715	110111454
Adjustment disorder	100.57	9.60	135	299995	10660	110278509
Suicide attempt	100.28	9.60	80	300050	103314	110185855
Sleep disorder	99.54	9.60	898	299232	197746	110091423
Drug resistance	98.67	9.60	17	300113	56357	110232812
Obstructive airways disorder	98.08	9.60	312	299818	45837	110243332
C-reactive protein	97.04	9.60	238	299892	30093	110259076
Drug ineffective for unapproved indication	96.72	9.60	82	300048	102756	110186413
Pericarditis	96.60	9.60	964	299166	218150	110071019
Wound infection	94.67	9.60	514	299616	95951	110193218
Wound	94.62	9.60	1013	299117	233424	110055745
Respiratory symptom	93.38	9.60	155	299975	14790	110274379
Obesity	93.03	9.60	576	299554	112775	110176394
Lower limb fracture	92.70	9.60	428	299702	74920	110214249
Vaginal flatulence	92.60	9.60	138	299992	12006	110277163
Total lung capacity increased	92.17	9.60	90	300040	5022	110284147
Bursitis	91.31	9.60	635	299495	129283	110159886
Glossodynia	90.39	9.60	961	299169	221043	110068126
Vomiting	90.35	9.60	3166	296964	907509	109381660
Oedema	89.30	9.60	917	299213	209059	110080110
Abdominal pain	89.18	9.60	1918	298212	511071	109778098
Antineutrophil cytoplasmic antibody positive	88.97	9.60	88	300042	4988	110284181
Angioedema	88.48	9.60	82	300048	98418	110190751
C-reactive protein abnormal	88.28	9.60	629	299501	129066	110160103
Shunt stenosis	87.31	9.60	52	300078	1364	110287805
X-ray abnormal	86.83	9.60	264	299866	37853	110251316
Eosinophilic granulomatosis with polyangiitis	86.64	9.60	125	300005	10561	110278608
Personality disorder	85.44	9.60	137	299993	12700	110276469
Nasal oedema	85.31	9.60	99	300031	6740	110282429
Sleep disorder due to general medical condition, insomnia type	84.92	9.60	534	299596	105109	110184060
Macular degeneration	84.77	9.60	184	299946	21475	110267694
Lupus vulgaris	84.16	9.60	242	299888	33641	110255528
Sleep disorder due to a general medical condition	83.59	9.60	321	299809	51791	110237378
Suicidal ideation	83.44	9.60	79	300051	93858	110195311
Total lung capacity abnormal	83.22	9.60	81	300049	4502	110284667
Lung disorder	83.20	9.60	800	299330	179247	110109922
Spirometry abnormal	81.34	9.60	87	300043	5410	110283759
Stomatitis	80.75	9.60	1103	299027	269139	110020030
Female genital tract fistula	78.44	9.60	152	299978	16367	110272802
Proctitis	78.24	9.60	154	299976	16773	110272396
Hand deformity	77.22	9.60	920	299210	217586	110071583
Pemphigus	76.52	9.60	905	299225	213665	110075504
Asthma-chronic obstructive pulmonary disease overlap syndrome	76.08	9.60	90	300040	6254	110282915
Arteriosclerosis coronary artery	75.01	9.60	192	299938	24926	110264243
Hyperhidrosis	74.11	9.60	260	299870	187038	110102131
Mite allergy	74.06	9.60	85	300045	5718	110283451
Mycotic allergy	73.95	9.60	86	300044	5868	110283301
Osteoarthritis	73.61	9.60	789	299341	181834	110107335
Lactic acidosis	73.51	9.60	86	300044	92725	110196444
Dust allergy	73.40	9.60	86	300044	5915	110283254
Injection site erythema	72.74	9.60	89	300041	94087	110195082
Hypotension	71.92	9.60	995	299135	522854	109766315
Conjunctivitis allergic	71.28	9.60	91	300039	6840	110282329
Radiculopathy	69.75	9.60	159	299971	19177	110269992
Anaphylactic reaction	68.95	9.60	128	300002	114172	110174997
Breast cancer stage III	68.05	9.60	407	299723	78710	110210459
Wrong technique in product usage process	68.05	9.60	82	300048	87266	110201903
Prescribed overdose	66.88	9.60	437	299693	87144	110202025
Gangrene	66.46	9.60	141	299989	16200	110272969
Nephrocalcinosis	66.24	9.60	48	300082	1766	110287403
Gait inability	66	9.60	612	299518	135764	110153405
Muscle injury	65.71	9.60	627	299503	140180	110148989
Accidental exposure to product	65.14	9.60	27	300103	49981	110239188
Injection site swelling	64.85	9.60	44	300086	61746	110227423
Disease progression	64.31	9.60	393	299737	243641	110045528
Night sweats	64.21	9.60	600	299530	133383	110155786
Arterial occlusive disease	63.32	9.60	133	299997	15175	110273994
Colitis	63.21	9.60	485	299645	101838	110187331
Taste disorder	63.20	9.60	347	299783	65040	110224129
Blood mercury abnormal	62.93	9.60	25	300105	257	110288912
Blister	62.67	9.60	915	299215	226461	110062708
Nasal obstruction	62.32	9.60	60	300070	3290	110285879
Diarrhoea	61.91	9.60	3728	296402	1135777	109153392
Agitation	61.86	9.60	134	299996	112917	110176252
Vaginal discharge	61.03	9.60	144	299986	17764	110271405
Sensory loss	60.98	9.60	161	299969	21296	110267873
Hepatic function abnormal	60.31	9.60	93	300037	89202	110199967
Impaired healing	60.01	9.60	806	299324	195911	110093258
Methaemoglobinaemia	59.87	9.60	97	300033	9071	110280098
Device expulsion	59.47	9.60	7	300123	30884	110258285
Bradycardia	59.45	9.60	219	299911	155298	110133871
Neurological symptom	59.27	9.60	131	299999	15477	110273692
Affect lability	58.31	9.60	145	299985	18492	110270677
Calciphylaxis	57.99	9.60	64	300066	4123	110285046
Interstitial lung disease	57.43	9.60	190	299940	139144	110150025
Hepatocellular injury	57.38	9.60	33	300097	50609	110238560
Hypoaesthesia	54.25	9.60	1174	298956	313049	109976120
Sinus congestion	54.18	9.60	194	299936	30265	110258904
Drug reaction with eosinophilia and systemic symptoms	54.02	9.60	87	300043	82008	110207161
Gastrointestinal procedural complication	53.92	9.60	26	300104	439	110288730
Amnesia	53.53	9.60	478	299652	104930	110184239
Recalled product	53.14	9.60	34	300096	1016	110288153
Injection site bruising	53.14	9.60	37	300093	51226	110237943
Throat clearing	52.84	9.60	62	300068	4271	110284898
Breast cancer stage II	52.72	9.60	179	299951	27196	110261973
Off label use	52.38	9.60	3440	296690	1496745	108792424
Seizure	52.30	9.60	368	299762	220817	110068352
Metabolic alkalosis	52.17	9.60	70	300060	5525	110283644
Neuroleptic malignant syndrome	52.02	9.60	14	300116	34045	110255124
Cardio-respiratory arrest	51.96	9.60	152	299978	115684	110173485
Eating disorder	51.90	9.60	193	299937	30665	110258504
Injection site pruritus	51.82	9.60	38	300092	51220	110237949
Prescribed underdose	51.48	9.60	328	299802	64846	110224323
Respiratory tract infection	51.46	9.60	352	299778	71265	110217904
Loss of consciousness	50.74	9.60	318	299812	195988	110093181
Inflammation	50.66	9.60	771	299359	192467	110096702
Poisoning deliberate	50.60	9.60	6	300124	26325	110262844
Muscle spasticity	50.22	9.60	212	299918	35703	110253466
Hepatic enzyme increased	49.79	9.60	1181	298949	319711	109969458
Hypercholesterolaemia	49.29	9.60	418	299712	90419	110198750
Cardiac arrest	49.18	9.60	322	299808	196431	110092738
Synovitis	48.90	9.60	1029	299101	273063	110016106
Poisoning	48.33	9.60	10	300120	29095	110260074
Segmental diverticular colitis	48.01	9.60	18	300112	156	110289013
Abdominal discomfort	47.95	9.60	1404	298726	392454	109896715
Vision blurred	47.81	9.60	184	299946	128838	110160331
Coordination abnormal	47.74	9.60	164	299966	25064	110264105
Skin haemorrhage	47.51	9.60	162	299968	24665	110264504
Paraesthesia oral	47.28	9.60	199	299931	33472	110255697
Acute kidney injury	46.96	9.60	1339	298791	634091	109655078
Retinitis	46.13	9.60	192	299938	32135	110257034
Anti-cyclic citrullinated peptide antibody positive	45.75	9.60	721	299409	181263	110107906
Live birth	45.54	9.60	334	299796	69150	110220019
Hip arthroplasty	45.39	9.60	283	299847	55530	110233639
Erythema	45.34	9.60	539	299591	290908	109998261
Liver disorder	45.11	9.60	587	299543	141656	110147513
Sneezing	44.88	9.60	189	299941	31795	110257374
Therapeutic product effect incomplete	44.84	9.60	855	299275	222950	110066219
Hemiplegia	44.78	9.60	150	299980	22632	110266537
Multiple organ dysfunction syndrome	44.44	9.60	236	299894	151474	110137695
Rhinorrhoea	44.39	9.60	450	299680	102216	110186953
Drug eruption	44.37	9.60	48	300082	53611	110235558
Pancytopenia	44.23	9.60	360	299770	209253	110079916
Sinus disorder	44.08	9.60	191	299939	32537	110256632
Motor dysfunction	43.88	9.60	156	299974	24250	110264919
Nicotine dependence	43.62	9.60	33	300097	1298	110287871
Cardiac failure	43.46	9.60	314	299816	187312	110101857
Intentional product misuse	43.39	9.60	199	299931	132705	110156464
Abdominal distension	43.36	9.60	692	299438	174411	110114758
Therapy cessation	43.12	9.60	35	300095	44822	110244347
Sarcoidosis	42.70	9.60	101	300029	12478	110276691
Pulmonary alveolar haemorrhage	42.60	9.60	136	299994	20014	110269155
Aggression	42.59	9.60	59	300071	59151	110230018
Cardiac murmur	42.23	9.60	155	299975	24473	110264696
Therapy partial responder	42.20	9.60	24	300106	37037	110252132
Small intestinal obstruction	41.87	9.60	186	299944	32027	110257142
Therapy interrupted	41.83	9.60	44	300086	49778	110239391
Pedal pulse abnormal	41.83	9.60	18	300112	230	110288939
Respiratory tract congestion	41.50	9.60	180	299950	30677	110258492
Fractional exhaled nitric oxide increased	41.45	9.60	26	300104	750	110288419
Disturbance in attention	41.45	9.60	65	300065	61930	110227239
Neutropenia	41.43	9.60	741	299389	373879	109915290
Normochromic normocytic anaemia	41.28	9.60	102	300028	12955	110276214
Swelling	41.26	9.60	1246	298884	349795	109939374
Exostosis	41.19	9.60	239	299891	45717	110243452
Agranulocytosis	41.06	9.60	65	300065	61695	110227474
Renal impairment	40.98	9.60	321	299809	188124	110101045
Migraine	40.14	9.60	672	299458	170980	110118189
Neuropathy peripheral	40.10	9.60	303	299827	178974	110110195
Calcium ionised decreased	39.88	9.60	24	300106	642	110288527
Blepharospasm	39.65	9.60	270	299860	54581	110234588
Ill-defined disorder	39.64	9.60	622	299508	156231	110132938
Ulcer haemorrhage	39.50	9.60	143	299987	22428	110266741
Blood calcium decreased	39.30	9.60	197	299933	35648	110253521
Irritability	39.27	9.60	43	300087	47766	110241403
Herpes zoster	39.23	9.60	156	299974	108223	110180946
Sputum purulent	39.15	9.60	36	300094	1862	110287307
Altered state of consciousness	38.93	9.60	60	300070	57566	110231603
Muscular weakness	38.69	9.60	915	299215	247553	110041616
5-hydroxyindolacetic acid in urine increased	38.68	9.60	16	300114	184	110288985
Serotonin syndrome	38.62	9.60	63	300067	59090	110230079
Alanine aminotransferase increased	38.59	9.60	316	299814	183457	110105712
COVID-19	38.58	9.60	452	299678	244608	110044561
Multiple drug therapy	38.37	9.60	74	300056	7940	110281229
Rheumatoid nodule	38.09	9.60	5	300125	20291	110268878
Blindness	38.01	9.60	26	300104	36333	110252836
Abortion spontaneous	37.90	9.60	23	300107	34259	110254910
Sinusitis	37.85	9.60	1064	299066	295624	109993545
Hypophosphataemic osteomalacia	37.69	9.60	20	300110	417	110288752
Respiratory depression	37.49	9.60	20	300110	31981	110257188
Bone marrow failure	37.41	9.60	62	300068	57786	110231383
Proctalgia	37.36	9.60	99	300031	13123	110276046
Rectal haemorrhage	37.36	9.60	493	299637	119340	110169829
Circulatory collapse	37.20	9.60	37	300093	42956	110246213
Adverse event	37.04	9.60	455	299675	108354	110180815
Thrombocytopenia	37.04	9.60	695	299435	348190	109940979
Hyperparathyroidism secondary	36.56	9.60	45	300085	3259	110285910
Overdose	36.50	9.60	432	299698	233362	110055807
Hypoparathyroidism	35.47	9.60	31	300099	1499	110287670
Musculoskeletal pain	35.23	9.60	695	299435	182328	110106841
Amyloid arthropathy	34.91	9.60	32	300098	1648	110287521
Feeling abnormal	34.71	9.60	318	299812	180393	110108776
Sopor	34.53	9.60	29	300101	36517	110252652
Acute hepatic failure	34.38	9.60	29	300101	36439	110252730
Anal inflammation	34.31	9.60	38	300092	2458	110286711
Multiple sclerosis relapse	34.23	9.60	52	300078	50188	110238981
Hypophosphataemia	34.04	9.60	179	299951	33003	110256166
Shunt occlusion	34.00	9.60	32	300098	1705	110287464
Feeding intolerance	33.69	9.60	27	300103	1157	110288012
Hungry bone syndrome	33.50	9.60	17	300113	322	110288847
Rib deformity	33.19	9.60	15	300115	217	110288952
Malaise	32.86	9.60	2179	297951	669640	109619529
Cytomegalovirus infection	32.80	9.60	61	300069	54383	110234786
Knee arthroplasty	32.19	9.60	293	299837	64655	110224514
Lower respiratory tract infection	32.17	9.60	876	299254	242230	110046939
Rhabdomyolysis	32.17	9.60	193	299937	120208	110168961
Hallucination	31.86	9.60	154	299976	101278	110187891
Nephrogenic systemic fibrosis	31.78	9.60	55	300075	5428	110283741
Cholestasis	31.67	9.60	81	300049	64437	110224732
Respiratory failure	31.31	9.60	404	299726	214928	110074241
Blood creatine phosphokinase increased	31.26	9.60	98	300032	72979	110216190
Procedural pain	31.25	9.60	184	299946	35381	110253788
Respiratory arrest	31.15	9.60	70	300060	58229	110230940
Discomfort	31.11	9.60	783	299347	213924	110075245
Oedema peripheral	31.04	9.60	1137	298993	327523	109961646
Lupus-like syndrome	30.81	9.60	203	299927	40589	110248580
Heart rate increased	30.81	9.60	246	299884	143588	110145581
Oxygen saturation decreased	30.69	9.60	275	299855	156707	110132462
Therapeutic reaction time decreased	30.66	9.60	53	300077	5226	110283943
Shock	30.59	9.60	62	300068	53526	110235643
Weight decreased	30.51	9.60	1558	298572	466499	109822670
Cerebral infarction	30.43	9.60	59	300071	51779	110237390
Miosis	30.07	9.60	11	300119	21972	110267197
Cerebral haemorrhage	30.05	9.60	84	300046	64884	110224285
Foetal death	30.00	9.60	4	300126	16041	110273128
Musculoskeletal stiffness	29.91	9.60	982	299148	278840	110010329
Capillaritis	29.91	9.60	35	300095	2404	110286765
Bone erosion	29.87	9.60	222	299908	46149	110243020
General physical health deterioration	29.87	9.60	1426	298704	423869	109865300
Urticaria	29.85	9.60	1102	299028	317755	109971414
Product prescribing error	29.63	9.60	59	300071	51272	110237897
Product storage error	29.50	9.60	11	300119	21717	110267452
Low density lipoprotein decreased	29.39	9.60	27	300103	1395	110287774
Cytomegalovirus infection reactivation	29.03	9.60	7	300123	18326	110270843
Intentional product use issue	28.86	9.60	879	299251	247027	110042142
Hyperparathyroidism	28.62	9.60	43	300087	3767	110285402
Decreased appetite	28.62	9.60	1572	298558	474274	109814895
Tremor	28.46	9.60	382	299748	201850	110087319
Acute respiratory distress syndrome	28.32	9.60	64	300066	53134	110236035
Device difficult to use	28.21	9.60	8	300122	18797	110270372
Confusional state	28.12	9.60	1548	298582	467132	109822037
Anti-cyclic citrullinated peptide antibody	28.03	9.60	118	300012	19846	110269323
Hyperphosphataemia	28.00	9.60	103	300027	16278	110272891
Onychomadesis	27.95	9.60	216	299914	45447	110243722
Blood parathyroid hormone increased	27.81	9.60	45	300085	4203	110284966
Inappropriate antidiuretic hormone secretion	27.20	9.60	31	300099	33820	110255349
Metabolic acidosis	27.11	9.60	159	299971	99585	110189584
Seronegative arthritis	27.01	9.60	88	300042	13089	110276080
Leukopenia	26.80	9.60	266	299864	148525	110140644
Musculoskeletal disorder	26.79	9.60	14	300116	22650	110266519
Carbuncle	26.77	9.60	26	300104	1441	110287728
Speech disorder	26.74	9.60	82	300048	61487	110227682
Laryngitis	26.73	9.60	202	299928	42209	110246960
Post transplant lymphoproliferative disorder	26.69	9.60	5	300125	15608	110273561
Sleep apnoea syndrome	26.48	9.60	43	300087	40404	110248765
Dehydration	26.40	9.60	967	299163	278544	110010625
Drug dose omission by device	26.25	9.60	4	300126	14512	110274657
Walking aid user	26.22	9.60	136	299994	24939	110264230
Forced expiratory volume decreased	26.12	9.60	87	300043	13089	110276080
Diplopia	26.08	9.60	46	300084	41848	110247321
Haemorrhoids	26.02	9.60	176	299954	35496	110253673
Blood glucose increased	25.95	9.60	232	299898	132264	110156905
Arteriovenous fistula occlusion	25.88	9.60	17	300113	532	110288637
Restlessness	25.83	9.60	73	300057	56186	110232983
Delirium	25.73	9.60	512	299618	134513	110154656
Food allergy	25.61	9.60	11	300119	19937	110269232
Hepatic cytolysis	25.60	9.60	71	300059	54982	110234187
Brain oedema	25.51	9.60	28	300102	31070	110258099
Burning sensation	25.44	9.60	99	300031	69113	110220056
Visual acuity reduced	25.27	9.60	30	300100	32143	110257026
Exposure via skin contact	25.25	9.60	3	300127	13144	110276025
Rhinitis allergic	25.22	9.60	106	300024	17816	110271353
Vasculitis	24.99	9.60	175	299955	35698	110253471
Arteriosclerosis	24.99	9.60	133	299997	24634	110264535
Haematotoxicity	24.95	9.60	13	300117	21069	110268100
Dyskinesia	24.93	9.60	65	300065	51381	110237788
SARS-CoV-2 test negative	24.92	9.60	30	300100	2123	110287046
Drug use disorder	24.79	9.60	9	300121	18065	110271104
Low turnover osteopathy	24.77	9.60	29	300101	1993	110287176
Acute graft versus host disease	24.59	9.60	3	300127	12878	110276291
Blood pressure inadequately controlled	24.53	9.60	60	300070	7573	110281596
Incorrect route of product administration	24.52	9.60	274	299856	63787	110225382
Liver function test abnormal	24.48	9.60	100	300030	68850	110220319
Mydriasis	24.31	9.60	15	300115	22142	110267027
Injection site rash	24.14	9.60	17	300113	23402	110265767
Hypoglycaemia	23.75	9.60	201	299929	115903	110173266
Extrapyramidal disorder	23.67	9.60	26	300104	28841	110260328
Coronary artery disease	23.60	9.60	107	300023	71583	110217586
Anaphylactic shock	23.58	9.60	67	300063	51479	110237690
Pneumonia	23.50	9.60	2720	297410	873994	109415175
Stress fracture	23.46	9.60	57	300073	7164	110282005
5-hydroxyindolacetic acid increased	23.36	9.60	10	300120	126	110289043
Epilepsy	23.30	9.60	392	299738	99817	110189352
Psychomotor hyperactivity	23.28	9.60	13	300117	20264	110268905
Dermatitis atopic	23.24	9.60	21	300109	25520	110263649
Creatinine renal clearance increased	23.19	9.60	38	300092	3587	110285582
Epstein-Barr virus infection	23.01	9.60	11	300119	18727	110270442
Flushing	22.95	9.60	178	299952	104558	110184611
Central nervous system lupus	22.87	9.60	23	300107	1330	110287839
Withdrawal syndrome	22.84	9.60	31	300099	31349	110257820
Maternal exposure timing unspecified	22.69	9.60	115	300015	20898	110268271
Pruritus	22.69	9.60	1319	298811	580241	109708928
Akathisia	22.68	9.60	9	300121	17104	110272065
Oropharyngeal pain	22.26	9.60	247	299883	135029	110154140
Bronchopulmonary aspergillosis	22.25	9.60	29	300101	29834	110259335
Cardiac failure congestive	22.05	9.60	283	299847	150717	110138452
Vascular device infection	21.96	9.60	96	300034	16416	110272753
Tendonitis	21.94	9.60	23	300107	26060	110263109
Bladder cancer	21.90	9.60	14	300116	20278	110268891
Spondylitis	21.71	9.60	74	300056	11264	110277905
Arthropathy	21.67	9.60	971	299159	286551	110002618
Swollen joint count	21.59	9.60	62	300068	8612	110280557
Hypotonia	21.33	9.60	8	300122	15737	110273432
Substance abuse	21.29	9.60	4	300126	12459	110276710
Onychomycosis	21.26	9.60	178	299952	38353	110250816
Melaena	21.24	9.60	105	300025	68652	110220517
Renal failure	21.14	9.60	461	299669	226113	110063056
Joint dislocation	21.08	9.60	162	299968	34028	110255141
Delusion	21.06	9.60	20	300110	23735	110265434
Ankylosing spondylitis	21.04	9.60	8	300122	15604	110273565
Acute myeloid leukaemia	20.98	9.60	45	300085	38065	110251104
Skin ulcer	20.94	9.60	95	300035	63550	110225619
Infusion related reaction	20.93	9.60	1249	298881	379913	109909256
Candida infection	20.80	9.60	64	300066	47945	110241224
Apathy	20.78	9.60	9	300121	16230	110272939
Memory impairment	20.74	9.60	690	299440	196254	110092915
Salivary gland calculus	20.73	9.60	12	300118	298	110288871
Stevens-Johnson syndrome	20.70	9.60	62	300068	46839	110242330
Tetany	20.69	9.60	36	300094	3568	110285601
Granuloma skin	20.65	9.60	3	300127	11280	110277889
Myocarditis	20.58	9.60	31	300099	30024	110259145
Pouchitis	20.48	9.60	22	300108	1375	110287794
Psychotic disorder	20.47	9.60	220	299910	50717	110238452
Unevaluable event	20.34	9.60	87	300043	59140	110230029
Nail disorder	20.03	9.60	243	299887	57692	110231477
Back pain	19.84	9.60	814	299316	370182	109918987
Throat tightness	19.75	9.60	38	300092	33451	110255718
Porphyria acute	19.74	9.60	102	300028	18678	110270491
Diabetic ketoacidosis	19.73	9.60	54	300076	42004	110247165
Swelling face	19.72	9.60	158	299972	92163	110197006
Congestive cardiomyopathy	19.64	9.60	7	300123	14212	110274957
Sinus bradycardia	19.62	9.60	31	300099	29452	110259717
Monoclonal immunoglobulin present	19.56	9.60	29	300101	2511	110286658
Drug effective for unapproved indication	19.53	9.60	7	300123	14160	110275009
Cytomegalovirus viraemia	19.52	9.60	12	300118	17752	110271417
Renal function test abnormal	19.48	9.60	61	300069	8885	110280284
Posterior reversible encephalopathy syndrome	19.47	9.60	39	300091	33822	110255347
Carcinoid tumour of the small bowel	19.23	9.60	13	300117	427	110288742
Tachycardia	19.22	9.60	468	299662	226177	110062992
Cutaneous T-cell lymphoma stage I	19.21	9.60	9	300121	142	110289027
Red blood cell sedimentation rate abnormal	19.09	9.60	23	300107	24486	110264683
Malignant neoplasm progression	19.05	9.60	346	299784	174221	110114948
Injection site haemorrhage	19.03	9.60	38	300092	32990	110256179
Open reduction of fracture	18.94	9.60	11	300119	275	110288894
Abdominal rigidity	18.88	9.60	35	300095	3645	110285524
Alopecia	18.87	9.60	1189	298941	363564	109925605
Injection site warmth	18.80	9.60	12	300118	17393	110271776
Muscle spasms	18.74	9.60	929	299201	277228	110011941
Eye pruritus	18.64	9.60	38	300092	32737	110256432
Catatonia	18.52	9.60	4	300126	11296	110277873
Fungal infection	18.47	9.60	73	300057	50733	110238436
Discoloured vomit	18.45	9.60	25	300105	1992	110287177
Product label confusion	18.45	9.60	115	300015	22562	110266607
Foot deformity	18.39	9.60	207	299923	48273	110240896
Arrhythmia	18.33	9.60	112	300018	69463	110219706
Blue toe syndrome	18.12	9.60	15	300115	673	110288496
Contusion	18.00	9.60	790	299340	232571	110056598
Granulomatous pneumonitis	17.97	9.60	10	300120	230	110288939
Intramedullary rod insertion	17.97	9.60	10	300120	230	110288939
Cold sweat	17.89	9.60	20	300110	22011	110267158
Illness	17.84	9.60	140	299990	82031	110207138
Gonorrhoea	17.77	9.60	10	300120	235	110288934
Rash maculo-papular	17.77	9.60	123	300007	74099	110215070
Gastrointestinal disorder	17.77	9.60	815	299315	241137	110048032
Nasopharyngitis	17.64	9.60	1270	298860	393091	109896078
Sedation complication	17.62	9.60	103	300027	19752	110269417
Blood bilirubin increased	17.59	9.60	297	299833	75675	110213494
Underdose	17.59	9.60	256	299874	63298	110225871
Bradyphrenia	17.58	9.60	5	300125	11723	110277446
Product preparation error	17.53	9.60	4	300126	10875	110278294
Hypomagnesaemia	17.43	9.60	245	299885	60125	110229044
Paranoia	17.43	9.60	21	300109	22353	110266816
Blood pressure fluctuation	17.42	9.60	125	300005	74699	110214470
Multimorbidity	17.30	9.60	21	300109	1499	110287670
Dystonia	17.30	9.60	27	300103	25778	110263391
Mucosal inflammation	17.26	9.60	172	299958	95969	110193200
N-telopeptide urine increased	17.23	9.60	6	300124	41	110289128
Surgery	17.21	9.60	56	300074	41227	110247942
Eye irritation	17.20	9.60	41	300089	33411	110255758
BK virus infection	17.19	9.60	7	300123	13099	110276070
Dissociation	17.15	9.60	3	300127	9839	110279330
Incorrect dose administered	17.15	9.60	189	299941	103452	110185717
Hallucination, visual	17.02	9.60	53	300077	39552	110249617
Constipation	17.01	9.60	1158	298972	356628	109932541
Syncope	16.96	9.60	419	299711	202117	110087052
Skin necrosis	16.96	9.60	20	300110	21492	110267677
Nephroangiosclerosis	16.96	9.60	12	300118	425	110288744
Blood calcium increased	16.94	9.60	95	300035	17945	110271224
Epidermal necrosis	16.91	9.60	30	300100	3020	110286149
Device malfunction	16.89	9.60	27	300103	25531	110263638
Flatulence	16.86	9.60	216	299914	51933	110237236
Fluid retention	16.81	9.60	169	299961	94138	110195031
Hypertension	16.80	9.60	1605	298525	508479	109780690
Lymphoma	16.72	9.60	18	300112	20153	110269016
Hepatic neoplasm	16.46	9.60	34	300096	3833	110285336
Pallor	16.44	9.60	88	300042	56379	110232790
Blood pH increased	16.41	9.60	20	300110	1434	110287735
Haemodynamic instability	16.27	9.60	23	300107	22865	110266304
Head banging	16.26	9.60	13	300117	555	110288614
Therapeutic response shortened	16.23	9.60	35	300095	29548	110259621
Myelodysplastic syndrome	16.22	9.60	50	300080	37434	110251735
Dry eye	16.22	9.60	87	300043	55706	110233463
Transfusion-related circulatory overload	16.20	9.60	16	300114	905	110288264
Bacterial disease carrier	16.19	9.60	25	300105	2244	110286925
Haematemesis	16.18	9.60	94	300036	59014	110230155
Mood swings	16.14	9.60	23	300107	22789	110266380
Pulmonary oedema	16.09	9.60	185	299945	100474	110188695
Oral candidiasis	16.03	9.60	189	299941	44571	110244598
Eye disorder	16.03	9.60	34	300096	28872	110260297
Erectile dysfunction	16.02	9.60	16	300114	18540	110270629
Hemiparesis	16.00	9.60	186	299944	43717	110245452
Skin toxicity	15.94	9.60	6	300124	11777	110277392
Disease recurrence	15.94	9.60	98	300032	60686	110228483
Exercise tolerance decreased	15.93	9.60	70	300060	11997	110277172
Disseminated intravascular coagulation	15.86	9.60	58	300072	41228	110247941
Polyneuropathy	15.86	9.60	40	300090	31972	110257197
Oesophageal perforation	15.84	9.60	21	300109	1638	110287531
Breast cancer female	15.81	9.60	7	300123	12461	110276708
Clostridium difficile colitis	15.74	9.60	185	299945	43593	110245576
Device issue	15.71	9.60	45	300085	34490	110254679
Ketoacidosis	15.68	9.60	4	300126	10083	110279086
Pathogen resistance	15.53	9.60	15	300115	17657	110271512
Pneumonia aspiration	15.46	9.60	308	299822	80925	110208244
Secretion discharge	15.44	9.60	101	300029	20143	110269026
Encephalopathy	15.40	9.60	143	299987	80912	110208257
Metastases to lymph nodes	15.38	9.60	11	300119	15021	110274148
Blood bicarbonate increased	15.34	9.60	19	300111	1385	110287784
Acute graft versus host disease in skin	15.33	9.60	5	300125	10735	110278434
Jaundice	15.27	9.60	96	300034	59140	110230029
Cystitis haemorrhagic	15.25	9.60	7	300123	12202	110276967
Grip strength	15.23	9.60	57	300073	9084	110280085
Cardiotoxicity	15.22	9.60	14	300116	16867	110272302
Haemophagocytic lymphohistiocytosis	15.20	9.60	40	300090	31519	110257650
Erythema multiforme	15.20	9.60	21	300109	21076	110268093
Lymphadenopathy	15.18	9.60	106	300024	63729	110225440
Immune reconstitution inflammatory syndrome	15.18	9.60	13	300117	16213	110272956
Mucormycosis	15.08	9.60	5	300125	10623	110278546
Neutrophil count decreased	15.06	9.60	234	299896	120707	110168462
Paradoxical drug reaction	15.06	9.60	4	300126	9813	110279356
Acute myocardial infarction	14.99	9.60	150	299980	83627	110205542
Hepatic failure	14.98	9.60	117	300013	68622	110220547
Gastrointestinal sounds abnormal	14.96	9.60	43	300087	5975	110283194
Hypertensive crisis	14.95	9.60	27	300103	24345	110264824
Rebound effect	14.93	9.60	11	300119	14795	110274374
Haemorrhage	14.83	9.60	202	299928	106490	110182679
Subarachnoid haemorrhage	14.80	9.60	37	300093	29665	110259504
Neutropenic sepsis	14.78	9.60	39	300091	30707	110258462
Enterocolonic fistula	14.77	9.60	8	300122	174	110288995
Acute coronary syndrome	14.73	9.60	25	300105	23087	110266082
Adrenal insufficiency	14.72	9.60	62	300068	42328	110246841
Injection site urticaria	14.68	9.60	15	300115	17200	110271969
Device dislocation	14.65	9.60	41	300089	31663	110257506
Product substitution issue	14.65	9.60	25	300105	23036	110266133
Immune thrombocytopenia	14.64	9.60	24	300106	22470	110266699
Basal cell carcinoma	14.64	9.60	68	300062	45202	110243967
Ocular hyperaemia	14.56	9.60	56	300074	39230	110249939
Hyperkalaemia	14.55	9.60	270	299860	135526	110153643
Osteoporosis	14.50	9.60	324	299806	86828	110202341
Body height decreased	14.50	9.60	62	300068	10501	110278668
Aspartate aminotransferase increased	14.46	9.60	327	299803	159609	110129560
Neoplasm malignant	14.39	9.60	52	300078	37091	110252078
Vaginal haemorrhage	14.32	9.60	29	300101	25045	110264124
Anosmia	14.31	9.60	8	300122	12464	110276705
Gynaecomastia	14.31	9.60	4	300126	9486	110279683
Bradypnoea	14.30	9.60	3	300127	8646	110280523
Finger deformity	14.28	9.60	145	299985	32947	110256222
Drug withdrawal syndrome	14.27	9.60	54	300076	38000	110251169
Intestinal obstruction	14.18	9.60	213	299917	53014	110236155
Somnolence	14.17	9.60	661	299469	296788	109992381
Lymph node palpable	14.10	9.60	8	300122	191	110288978
Atypical femur fracture	14.09	9.60	43	300087	6176	110282993
Hypophosphatasia	14.07	9.60	7	300123	127	110289042
Nightmare	14.02	9.60	56	300074	38807	110250362
Fracture nonunion	14.01	9.60	19	300111	1515	110287654
Immunodeficiency	13.99	9.60	56	300074	38782	110250387
Paralysis	13.99	9.60	13	300117	15587	110273582
Appetite disorder	13.92	9.60	58	300072	9711	110279458
Shunt aneurysm	13.91	9.60	5	300125	38	110289131
Diversion colitis	13.90	9.60	4	300126	13	110289156
Abdominal pain upper	13.89	9.60	1114	299016	347997	109941172
Myalgia	13.86	9.60	479	299651	221902	110067267
Blood 25-hydroxycholecalciferol decreased	13.85	9.60	11	300119	465	110288704
Adverse drug reaction	13.85	9.60	380	299750	105179	110183990
Nerve degeneration	13.83	9.60	9	300121	277	110288892
Growth hormone deficiency	13.83	9.60	11	300119	466	110288703
Haematochezia	13.81	9.60	411	299719	115113	110174056
Creatinine renal clearance decreased	13.80	9.60	104	300026	21711	110267458
Primary familial brain calcification	13.79	9.60	5	300125	39	110289130
Amenorrhoea	13.71	9.60	4	300126	9227	110279942
Weight fluctuation	13.69	9.60	105	300025	22040	110267129
Shock haemorrhagic	13.53	9.60	34	300096	27213	110261956
Hepatic necrosis	13.51	9.60	5	300125	9917	110279252
Tuberculosis	13.51	9.60	17	300113	17757	110271412
Electrocardiogram QT prolonged	13.51	9.60	211	299919	108749	110180420
Atrioventricular block complete	13.48	9.60	21	300109	20061	110269108
Bronchiectasis	13.47	9.60	155	299975	36338	110252831
Epistaxis	13.42	9.60	261	299869	130111	110159058
Adverse reaction	13.41	9.60	131	299999	29463	110259706
Platelet count decreased	13.31	9.60	501	299629	229942	110059227
Gastrointestinal stoma output increased	13.31	9.60	15	300115	989	110288180
Progressive multifocal leukoencephalopathy	13.30	9.60	30	300100	24926	110264243
Hypothalamo-pituitary disorder	13.28	9.60	26	300104	2820	110286349
Thrombotic microangiopathy	13.25	9.60	38	300092	29111	110260058
Polyomavirus-associated nephropathy	13.25	9.60	3	300127	8198	110280971
Monoclonal immunoglobulin increased	13.24	9.60	12	300118	609	110288560
Unresponsive to stimuli	13.24	9.60	110	300020	63680	110225489
Eosinophilic cellulitis	13.20	9.60	9	300121	300	110288869
Hepatitis acute	13.20	9.60	19	300111	18747	110270422
Hemianopia	13.14	9.60	26	300104	2842	110286327
Urine calcium/creatinine ratio increased	13.10	9.60	7	300123	148	110289021
Failure to thrive	13.09	9.60	72	300058	13502	110275667
Blood follicle stimulating hormone increased	13.05	9.60	10	300120	401	110288768
Fracture	13.05	9.60	30	300100	24758	110264411
Product monitoring error	13.02	9.60	4	300126	8923	110280246
Breast cancer	13.00	9.60	57	300073	38485	110250684
General symptom	12.98	9.60	53	300077	8793	110280376
Febrile bone marrow aplasia	12.97	9.60	17	300113	17448	110271721
Mood altered	12.83	9.60	24	300106	21351	110267818
Complication of device insertion	12.82	9.60	4	300126	8834	110280335
Injection site mass	12.79	9.60	30	300100	24583	110264586
Urinary retention	12.78	9.60	124	300006	69559	110219610
Tinnitus	12.75	9.60	104	300026	60436	110228733
Atypical fracture	12.74	9.60	15	300115	1037	110288132
Depressed level of consciousness	12.74	9.60	221	299909	112057	110177112
Hepatic cirrhosis	12.74	9.60	256	299874	67370	110221799
Aphasia	12.71	9.60	228	299902	58769	110230400
Body mass index abnormal	12.53	9.60	14	300116	914	110288255
Soft tissue mass	12.53	9.60	18	300112	1515	110287654
Pulmonary calcification	12.52	9.60	11	300119	536	110288633
Quality of life decreased	12.48	9.60	12	300118	14157	110275012
Paraesthesia	12.44	9.60	891	299239	275630	110013539
Oncocytoma	12.38	9.60	4	300126	21	110289148
Papule	12.37	9.60	6	300124	10127	110279042
Cardiogenic shock	12.30	9.60	98	300032	57240	110231929
Anti-saccharomyces cerevisiae antibody test positive	12.29	9.60	5	300125	55	110289114
Fungal cystitis	12.22	9.60	4	300126	22	110289147
Delayed graft function	12.16	9.60	32	300098	4225	110284944
Poliomyelitis	12.13	9.60	5	300125	57	110289112
Heavy menstrual bleeding	12.08	9.60	16	300114	16349	110272820
Pancreatitis acute	12.03	9.60	105	300025	60169	110229000
Headache	11.99	9.60	2160	297970	880217	109408952
Sedation	11.96	9.60	126	300004	69557	110219612
Pharyngitis	11.94	9.60	32	300098	25066	110264103
Product dose omission in error	11.94	9.60	29	300101	23483	110265686
Ear pain	11.93	9.60	207	299923	53019	110236150
Fibrous histiocytoma	11.92	9.60	13	300117	826	110288343
Productive cough	11.91	9.60	400	299730	113905	110175264
Urinary incontinence	11.89	9.60	80	300050	48507	110240662
Caesarean section	11.83	9.60	12	300118	13805	110275364
Oral herpes	11.78	9.60	54	300076	36026	110253143
Coagulopathy	11.78	9.60	64	300066	40847	110248322
Toxic skin eruption	11.69	9.60	37	300093	27478	110261691
Spinal cord injury lumbar	11.68	9.60	5	300125	63	110289106
Autoimmune colitis	11.62	9.60	20	300110	1965	110287204
Haematoma	11.62	9.60	102	300028	58374	110230795
Hepatotoxicity	11.61	9.60	239	299891	63161	110226008
Enterocolitis bacterial	11.58	9.60	12	300118	719	110288450
Muscle twitching	11.53	9.60	42	300088	29893	110259276
Congenital knee deformity	11.53	9.60	4	300126	27	110289142
Tongue oedema	11.51	9.60	4	300126	8252	110280917
Drug dependence	11.44	9.60	84	300046	49936	110239233
Graft versus host disease	11.39	9.60	21	300109	18785	110270384
Labelled drug-drug interaction medication error	11.36	9.60	41	300089	29261	110259908
Endophthalmitis	11.36	9.60	4	300126	8183	110280986
Septic shock	11.33	9.60	333	299797	157195	110131974
Personality change	11.32	9.60	8	300122	10994	110278175
Fear of injection	11.30	9.60	5	300125	8906	110280263
Abnormal behaviour	11.28	9.60	61	300069	38978	110250191
Diffuse large B-cell lymphoma	11.28	9.60	16	300114	15882	110273287
Intestinal haemorrhage	11.24	9.60	3	300127	7338	110281831
Secondary immunodeficiency	11.23	9.60	33	300097	4643	110284526
Bronchial wall thickening	11.16	9.60	26	300104	3181	110285988
Rash pustular	11.14	9.60	11	300119	12818	110276351
Gluten sensitivity	11.11	9.60	10	300120	503	110288666
Gastroenteritis bacterial	11.11	9.60	10	300120	503	110288666
Death neonatal	11.10	9.60	18	300112	1685	110287484
Femur fracture	11.10	9.60	176	299954	44293	110244876
Status epilepticus	11.07	9.60	46	300084	31525	110257644
Chronic kidney disease-mineral and bone disorder	11.07	9.60	11	300119	627	110288542
Skin exfoliation	11.07	9.60	314	299816	87337	110201832
Herpes simplex	11.05	9.60	16	300114	15748	110273421
Product prescribing issue	11.04	9.60	11	300119	12761	110276408
Generalised tonic-clonic seizure	11.03	9.60	95	300035	54585	110234584
Obsessive-compulsive disorder	11.01	9.60	3	300127	7238	110281931
Foreign body in throat	11.00	9.60	14	300116	1049	110288120
Face oedema	10.99	9.60	50	300080	33419	110255750
Transient ischaemic attack	10.85	9.60	116	300014	63866	110225303
SARS-CoV-2 antibody test positive	10.83	9.60	9	300121	406	110288763
Guillain-Barre syndrome	10.81	9.60	8	300122	10736	110278433
Injection site induration	10.79	9.60	9	300121	11374	110277795
Hypothermia	10.74	9.60	36	300094	26266	110262903
Facial paralysis	10.69	9.60	32	300098	24182	110264987
Large intestine polyp	10.68	9.60	74	300056	15043	110274126
Leiomyoma	10.66	9.60	9	300121	415	110288754
Mesenteric phlebosclerosis	10.60	9.60	3	300127	9	110289160
Pulmonary toxicity	10.59	9.60	20	300110	17726	110271443
Electrolyte imbalance	10.58	9.60	150	299980	36878	110252291
Rash	10.50	9.60	2016	298114	818948	109470221
Drug level increased	10.50	9.60	81	300049	47638	110241531
Haematopoietic stem cell mobilisation	10.50	9.60	9	300121	424	110288745
Blood pressure decreased	10.49	9.60	235	299895	114856	110174313
Cytopenia	10.49	9.60	44	300086	30072	110259097
Nodule	10.48	9.60	135	299995	32496	110256673
Cardiomyopathy	10.47	9.60	51	300079	33474	110255695
Swollen tongue	10.42	9.60	109	300021	60253	110228916
Intracranial pressure increased	10.40	9.60	8	300122	10527	110278642
Plantar fasciitis	10.39	9.60	34	300096	5067	110284102
Pelvic pain	10.39	9.60	17	300113	15925	110273244
Calcification metastatic	10.37	9.60	6	300124	149	110289020
Hypermagnesaemia	10.36	9.60	17	300113	1606	110287563
Ureteral stent removal	10.36	9.60	3	300127	10	110289159
Intermenstrual bleeding	10.31	9.60	3	300127	6931	110282238
Myopathy	10.31	9.60	34	300096	24926	110264243
Pulmonary pain	10.28	9.60	39	300091	6254	110282915
Central nervous system mass	10.28	9.60	12	300118	822	110288347
Eye injury	10.24	9.60	45	300085	7710	110281459
Immunosuppressant drug level decreased	10.23	9.60	23	300107	2748	110286421
Hyperthermia	10.21	9.60	27	300103	21245	110267924
Cystitis	10.21	9.60	243	299887	65793	110223376
Wall motion score index abnormal	10.20	9.60	12	300118	829	110288340
Skin laceration	10.16	9.60	52	300078	33701	110255468
Hypervitaminosis B12	10.15	9.60	3	300127	11	110289158
Tumour lysis syndrome	10.12	9.60	46	300084	30755	110258414
Polyglandular disorder	10.12	9.60	7	300123	239	110288930
Asthenia	10.01	9.60	2066	298064	686933	109602236
Respiratory tract infection bacterial	10.00	9.60	21	300109	2395	110286774
Abnormal dreams	9.95	9.60	12	300118	12768	110276401
Polyarthritis	9.94	9.60	23	300107	18940	110270229
Pulseless electrical activity	9.90	9.60	19	300111	16738	110272431
Tension headache	9.89	9.60	7	300123	9611	110279558
Hepatitis B	9.88	9.60	7	300123	9605	110279564
Hypergastrinaemia	9.88	9.60	8	300122	348	110288821
Foetal exposure during pregnancy	9.86	9.60	4	300126	7501	110281668
Hepatitis B reactivation	9.81	9.60	4	300126	7480	110281689
Metastases to lung	9.81	9.60	31	300099	23032	110266137
Spinal fusion surgery	9.81	9.60	50	300080	9106	110280063
Pathological fracture	9.78	9.60	61	300069	11971	110277198
Respiratory acidosis	9.72	9.60	14	300116	13812	110275357
Joint injury	9.71	9.60	66	300064	39928	110249241
Eye pain	9.68	9.60	88	300042	50011	110239158
Gestational diabetes	9.61	9.60	4	300126	7385	110281784

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	P03AX05	ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ECTOPARASITICIDES, INCL. SCABICIDES, INSECTICIDES AND REPELLENTS ECTOPARASITICIDES, INCL. SCABICIDES Other ectoparasiticides, incl. scabicides
FDA PE	N0000010282	Skin Barrier Activity
MeSH PA	D000934	Antifoaming Agents
MeSH PA	D003879	Dermatologic Agents
MeSH PA	D004643	Emollients
MeSH PA	D013501	Surface-Active Agents
CHEBI has role	CHEBI:35442	antiparasitic agent
CHEBI has role	CHEBI:35610	antineoplastic agent
CHEBI has role	CHEBI:49201	anti-ulcer drug
CHEBI has role	CHEBI:50177	dermatologic drug
CHEBI has role	CHEBI:50748	antipsoriatic
CHEBI has role	CHEBI:35480	analgesic

Related Drugs by ATC class:

P03AX Other ectoparasiticides, incl. scabicides 4 drugs

abametapirbenzyl alcoholbenzyl benzoatemalathion

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Diaper rash	indication	91487003

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4018922	VUID
N0000147215	NUI
D01540	KEGG_DRUG
4018922	VANDF
4019331	VANDF
C1113707	UMLSCUI
CHEBI:31498	CHEBI
CHEMBL2108200	ChEMBL_ID
DB11074	DRUGBANK_ID
CHEMBL4297192	ChEMBL_ID
C501844	MESH_SUPPLEMENTAL_RECORD_UI
C013830	MESH_SUPPLEMENTAL_RECORD_UI
DB09512	DRUGBANK_ID
DB14005	DRUGBANK_ID
1299921	RXNORM
4607	MMSL
5175	MMSL
5464	MMSL
d01027	MMSL
001144	NDDF
001915	NDDF
387442005	SNOMEDCT_US
396031000	SNOMEDCT_US
420874002	SNOMEDCT_US
77898008	SNOMEDCT_US
D012841	MESH_DESCRIPTOR_UI
6433516	PUBCHEM_CID
TYU5GP6XGE	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Simethicone	HUMAN OTC DRUG LABEL	1	10267-5328	CAPSULE, LIQUID FILLED	180 mg	ORAL	Export only	1 sections
Gas Relief Ultra Strength	HUMAN OTC DRUG LABEL	1	53345-003	CAPSULE, LIQUID FILLED	180 mg	ORAL	OTC Monograph Drug	10 sections
Infants Relief Non-Staining Formula	HUMAN OTC DRUG LABEL	1	59779-102	LIQUID	20 mg	ORAL	OTC MONOGRAPH FINAL	10 sections