benzyl alcohol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
334 100-51-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • benzyl alcohol
  • benzenemethanol
  • phenylmethanol
  • phenylcarbinol
  • hydroxytoluene
A colorless liquid with a sharp burning taste and slight odor. It is used as a local anesthetic and to reduce pain associated with LIDOCAINE injection. Also, it is used in the manufacture of other benzyl compounds, as a pharmaceutic aid, and in perfumery and flavoring.
  • Molecular weight: 108.14
  • Formula: C7H8O
  • CLOGP: 1.10
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: -0.61
  • ROTB: 1

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK1,JAK2,MAP3K21,MAP3K7,MAPK7,MAPK9,MTOR,NTRK2,PDK2,PDK4,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,TEK,TTK,ULK1 38
kinase-selectivity-class ACVR2A,ACVR2B,AXL,BRAF,EPHB4,ERBB2,GRK2,PDK4,SIK2,SIK3 10
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
April 9, 2009 FDA SHIONOGI INC

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC P03AX06 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ECTOPARASITICIDES, INCL. SCABICIDES, INSECTICIDES AND REPELLENTS
ECTOPARASITICIDES, INCL. SCABICIDES
Other ectoparasiticides, incl. scabicides
FDA EPC N0000181811 Pediculicide
CHEBI has role CHEBI:22586 antioxidant
CHEBI has role CHEBI:25212 metabolite
CHEBI has role CHEBI:35442 antiparasitic agent
CHEBI has role CHEBI:46787 solvent
CHEBI has role CHEBI:48318 fragrance
MeSH PA D000777 Anesthetics
MeSH PA D000779 Anesthetics, Local
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018689 Sensory System Agents

Related Drugs by ATC class:

P03AX Other ectoparasiticides, incl. scabicides 4 drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Skin irritation indication 367466007
Itching of skin indication 418363000
Peptic ulcer contraindication 13200003 DOID:750
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Contact dermatitis contraindication 40275004 DOID:2773
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Diabetes mellitus contraindication 73211009 DOID:9351
Chronic idiopathic constipation contraindication 82934008
Open wound contraindication 125643001
Gastrointestinal obstruction contraindication 126765001
Bladder outflow obstruction contraindication 236645006
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Hypertensive urgency contraindication 443482000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
LKG8494WBH UNII
4017798 VUID
N0000146159 NUI
D00077 KEGG_DRUG
1426 RXNORM
C0005100 UMLSCUI
CHEBI:17987 CHEBI
010 PDB_CHEM_ID
CHEMBL720 ChEMBL_ID
244 PUBCHEM_CID
DB06770 DRUGBANK_ID
D019905 MESH_DESCRIPTOR_UI
923 INN_ID
11807 MMSL
NOCODE MMSL
4017445 VANDF
4017798 VANDF
003192 NDDF
400850005 SNOMEDCT_US
55902002 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
ITCH X HUMAN OTC DRUG LABEL 2 0225-0495 GEL 10 g TOPICAL OTC Monograph Drug 14 sections
ITCH-X HUMAN OTC DRUG LABEL 2 0225-0516 SPRAY 10 g TOPICAL OTC monograph not final 13 sections
Walgreens Unscented Pain Relieving HUMAN OTC DRUG LABEL 2 0363-6752 CREAM 100 mg TOPICAL OTC Monograph Drug 14 sections
Walgreens Lidocaine Plus Cream HUMAN OTC DRUG LABEL 2 0363-9951 CREAM 100 mg TOPICAL OTC Monograph Drug 14 sections
Ivarest HUMAN OTC DRUG LABEL 3 10157-9077 CREAM 10.50 g TOPICAL OTC Monograph Drug 14 sections
Orajel Toothache Rinse HUMAN OTC DRUG LABEL 2 10237-764 LIQUID 2.70 mg TOPICAL OTC Monograph Drug 11 sections
Nitrotan HUMAN OTC DRUG LABEL 4 11960-0049 AEROSOL, SPRAY 0.06 g TOPICAL OTC monograph not final 9 sections
Cipro HC HUMAN PRESCRIPTION DRUG LABEL 3 16590-053 SUSPENSION 9 mg AURICULAR (OTIC) NDA 9 sections
ZilactinEarly Relief Cold Sore HUMAN OTC DRUG LABEL 1 42829-468 GEL 0.10 g TOPICAL OTC Monograph Drug 10 sections
Ivy-Dry Super HUMAN OTC DRUG LABEL 3 49546-105 SPRAY 100 mg TOPICAL OTC monograph not final 13 sections
Ivy-Dry Super HUMAN OTC DRUG LABEL 3 49546-106 SPRAY 100 mg TOPICAL OTC monograph not final 13 sections
Ivy Dry HUMAN OTC DRUG LABEL 3 49546-201 CREAM 10 g TOPICAL OTC monograph not final 14 sections
Lidocaine Plus Pain Relieving HUMAN OTC DRUG LABEL 2 51316-175 LIQUID 100 mg TOPICAL OTC Monograph Drug 13 sections
AVERTEAX HUMAN OTC DRUG LABEL 1 54866-002 CREAM 10 mg TOPICAL OTC monograph not final 11 sections
Cipro HUMAN PRESCRIPTION DRUG LABEL 3 54868-4365 SUSPENSION 9 mg AURICULAR (OTIC) NDA 10 sections
Salonpas LIDOCAINE PLUS HUMAN OTC DRUG LABEL 2 55328-901 LIQUID 10 g TOPICAL OTC Monograph Drug 15 sections
Salonpas LIDOCAINE PLUS HUMAN OTC DRUG LABEL 2 55328-902 CREAM 10 g TOPICAL OTC Monograph Drug 14 sections
shing-Releev HUMAN OTC DRUG LABEL 3 63287-420 LIQUID 5 mg TOPICAL OTC monograph not final 8 sections
Fast Freeze Lidocaine Roll-On HUMAN OTC DRUG LABEL 2 66902-235 LIQUID 10 mg TOPICAL OTC Monograph Drug 14 sections
CVS Health Lidocaine PlusPain Relieving HUMAN OTC DRUG LABEL 2 66902-758 CREAM 100 mg TOPICAL OTC Monograph Drug 13 sections
Pain Relieving Cream Lidocaine HUMAN OTC DRUG LABEL 2 69396-139 CREAM 10 g TOPICAL OTC Monograph Drug 14 sections
Thermacare Heat Therapy Max Strength Lidocaine Pain Relief Rollon HUMAN OTC DRUG LABEL 2 69693-002 LIQUID 10 g TOPICAL OTC Monograph Drug 10 sections
Thermacare Heat Therapy Max Strength Lidocaine Pain Relief Gel HUMAN OTC DRUG LABEL 2 69693-003 GEL 10 g TOPICAL OTC Monograph Drug 10 sections
Thermacare Max Strength Lidocaine HUMAN OTC DRUG LABEL 2 69693-004 SPRAY 10 g TOPICAL OTC Monograph Drug 10 sections
CVS Maximum Strength LIDOCAINE PLUS HUMAN OTC DRUG LABEL 2 69842-573 SPRAY 10 g TOPICAL OTC Monograph Drug 15 sections
HealthWise Lidocaine Plus Cream HUMAN OTC DRUG LABEL 2 71101-037 CREAM 10 g TOPICAL OTC Monograph Drug 13 sections
Protocoxil HUMAN OTC DRUG LABEL 1 71416-001 GEL 100 mg TOPICAL OTC monograph not final 12 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 3 73166-602 GEL 0.30 g TOPICAL unapproved drug other 5 sections
Carpal Comfort HUMAN OTC DRUG LABEL 2 73214-001 CREAM 10 mg TOPICAL OTC monograph not final 12 sections
Meijer Pain Lidocaine Plus RelievingAnalgesic HUMAN OTC DRUG LABEL 2 79481-0084 LIQUID 100 mg TOPICAL OTC Monograph Drug 15 sections