lymecycline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibiotics, protein-synthesis inhibitors, tetracycline derivatives | 1619 | 992-21-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A semisynthetic antibiotic related to TETRACYCLINE. It is more readily absorbed than TETRACYCLINE and can be used in lower doses.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.60 | g | O |
| 0.60 | g | P |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 99 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug reaction with eosinophilia and systemic symptoms | 62.11 | 37.95 | 20 | 619 | 33816 | 63454567 |
| Swelling face | 42.97 | 37.95 | 18 | 621 | 63457 | 63424926 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug reaction with eosinophilia and systemic symptoms | 53.54 | 36.14 | 22 | 900 | 64222 | 79679244 |
| Hidradenitis | 46.58 | 36.14 | 10 | 912 | 3034 | 79740432 |
| Swelling face | 44.83 | 36.14 | 20 | 902 | 71192 | 79672274 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01AA04 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE TETRACYCLINES Tetracyclines |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D000890 | Anti-Infective Agents |
| CHEBI has role | CHEBI:33281 | antibiotics |
| CHEBI has role | CHEBI:35820 | antiprotozoal drugs |
| CHEBI has role | CHEBI:36047 | antibacterial drugs |
| CHEBI has role | CHEBI:48001 | protein synthesis inhibitors |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 1.99 | acidic |
| pKa2 | 3.72 | acidic |
| pKa3 | 7.83 | acidic |
| pKa4 | 9.46 | acidic |
| pKa5 | 11.9 | acidic |
| pKa6 | 13.04 | acidic |
| pKa7 | 13.7 | acidic |
| pKa8 | 10.16 | Basic |
| pKa9 | 9.21 | Basic |
| pKa10 | 8.44 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| N0000167346 | NUI |
| D06884 | KEGG_DRUG |
| C0024200 | UMLSCUI |
| CHEBI:59040 | CHEBI |
| CHEMBL2103929 | ChEMBL_ID |
| D008194 | MESH_DESCRIPTOR_UI |
| DB00256 | DRUGBANK_ID |
| 10912 | IUPHAR_LIGAND_ID |
| 1679 | INN_ID |
| 7D6EM3S13P | UNII |
| 54707177 | PUBCHEM_CID |
| 6513 | RXNORM |
| 003993 | NDDF |
| 387548007 | SNOMEDCT_US |
| 96077007 | SNOMEDCT_US |
Pharmaceutical products:
None