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lucanthone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1616 | 479-50-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
One of the SCHISTOSOMICIDES, it has been replaced largely by HYCANTHONE and more recently PRAZIQUANTEL. (From Martindale The Extrapharmacopoeia, 30th ed., p46)
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000871 | Anthelmintics |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000977 | Antiparasitic Agents |
| MeSH PA | D000980 | Antiplatyhelmintic Agents |
| MeSH PA | D012556 | Schistosomicides |
| CHEBI has role | CHEBI:25435 | mutagen |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| CHEBI has role | CHEBI:38941 | schistosomicide drug |
| CHEBI has role | CHEBI:47868 | photosensitizing agent |
| CHEBI has role | CHEBI:50266 | prodrug |
| CHEBI has role | CHEBI:50276 | EC 5.99.1.2 (DNA topoisomerase) inhibitor |
| CHEBI has role | CHEBI:50750 | EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor |
| CHEBI has role | CHEBI:60809 | adjuvant |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.72 | Basic |
| pKa2 | 3.44 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| DNA-(apurinic or apyrimidinic site) lyase | Enzyme | IC50 | 5.30 | CHEMBL | |||||
| Microtubule-associated protein tau | Structural | IC50 | 4.96 | CHEMBL | |||||
| Amyloid beta A4 protein | Membrane other | IC50 | 4.62 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D04791 | KEGG_DRUG |
| C0024071 | UMLSCUI |
| CHEBI:51052 | CHEBI |
| CHEMBL279014 | ChEMBL_ID |
| DB04967 | DRUGBANK_ID |
| CHEMBL2007389 | ChEMBL_ID |
| D008154 | MESH_DESCRIPTOR_UI |
| 10180 | PUBCHEM_CID |
| 337 | INN_ID |
| 548-57-2 | SECONDARY_CAS_RN |
| FC6D57000M | UNII |
| 002982 | NDDF |
| 004876 | NDDF |
| 68310009 | SNOMEDCT_US |
| FC6D57000M | INXIGHT DRUGS |
Pharmaceutical products:
None