loxoprofen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory agents, ibuprofen derivatives 1615 68767-14-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • loxoprofen sodium hydrate
  • loxonin
  • loxoprofen
  • loxoprofen sodium
  • sodium loxoprofen
  • Molecular weight: 246.31
  • Formula: C15H18O3
  • CLOGP: 1.97
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 54.37
  • ALOGS: -3.57
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 23, 2006 PMDA Lead Chemical Co., Ltd.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Platelet count decreased 320.53 19.16 225 11882 115897 63361018
Interstitial lung disease 315.18 19.16 177 11930 61731 63415184
Hepatic function abnormal 224.36 19.16 119 11988 37023 63439892
Malignant neoplasm progression 172.06 19.16 135 11972 81986 63394929
Neutrophil count decreased 161.60 19.16 112 11995 56294 63420621
Osteonecrosis of jaw 132.86 19.16 83 12024 35040 63441875
White blood cell count decreased 128.41 19.16 145 11962 138959 63337956
Anaemia 126.02 19.16 211 11896 293219 63183696
Fatigue 109.72 19.16 19 12088 888009 62588906
Disseminated intravascular coagulation 106.44 19.16 58 12049 18993 63457922
Drug eruption 103.97 19.16 66 12041 28628 63448287
Drug ineffective 96.07 19.16 40 12067 1044725 62432190
Cerebral infarction 89.16 19.16 56 12051 23837 63453078
Decreased appetite 77.83 19.16 157 11950 250895 63226020
Spinal compression fracture 75.69 19.16 42 12065 14241 63462674
Gastrointestinal perforation 69.98 19.16 26 12081 3465 63473450
Erythema multiforme 68.24 19.16 35 12072 10134 63466781
Pyrexia 66.85 19.16 219 11888 470259 63006656
Enterocolitis 64.45 19.16 31 12076 7827 63469088
Altered state of consciousness 62.74 19.16 46 12061 25184 63451731
Upper respiratory tract inflammation 62.60 19.16 22 12085 2501 63474414
Febrile neutropenia 61.41 19.16 93 12014 118356 63358559
Drug-induced liver injury 61.11 19.16 55 12052 40167 63436748
Cardiac failure 61.07 19.16 80 12027 89062 63387853
Renal impairment 55.48 19.16 76 12031 88279 63388636
Haemorrhage subcutaneous 51.78 19.16 20 12087 2963 63473952
Joint swelling 50.52 19.16 3 12104 327663 63149252
Pneumonia bacterial 47.88 19.16 27 12080 9438 63467477
Drug intolerance 47.06 19.16 3 12104 308658 63168257
Iron deficiency anaemia 46.49 19.16 35 12072 19934 63456981
Liver disorder 46.11 19.16 54 12053 53633 63423282
Enteritis infectious 43.24 19.16 16 12091 2108 63474807
Pain 42.89 19.16 47 12060 740581 62736334
Hypoalbuminaemia 42.36 19.16 27 12080 11778 63465137
Femoral neck fracture 42.26 19.16 24 12083 8499 63468416
Ileus 41.55 19.16 29 12078 14696 63462219
Drug hypersensitivity 39.62 19.16 6 12101 310681 63166234
Aspartate aminotransferase increased 37.34 19.16 64 12043 90213 63386702
Fulminant type 1 diabetes mellitus 37.14 19.16 10 12097 465 63476450
Peripheral swelling 36.64 19.16 4 12103 265938 63210977
Swelling 35.85 19.16 5 12102 275373 63201542
Peritonitis 35.41 19.16 28 12079 17126 63459789
Paronychia 34.03 19.16 18 12089 5547 63471368
Lymphocyte count decreased 33.90 19.16 35 12072 30222 63446693
Herpes zoster 32.20 19.16 57 12050 82405 63394510
Ascites 31.74 19.16 39 12068 40689 63436226
Pharyngitis 31.49 19.16 28 12079 20115 63456800
Asteatosis 31.11 19.16 6 12101 59 63476856
Alanine aminotransferase increased 30.99 19.16 64 12043 103706 63373209
Colon cancer 29.15 19.16 20 12087 9858 63467057
Heat illness 29.09 19.16 7 12100 206 63476709
Hypopituitarism 28.44 19.16 10 12097 1138 63475777
Gastroenteritis 28.43 19.16 30 12077 26560 63450355
Pulmonary alveolar haemorrhage 28.26 19.16 15 12092 4653 63472262
Stevens-Johnson syndrome 28.20 19.16 29 12078 24921 63451994
Breast cancer 27.94 19.16 40 12067 48343 63428572
Weight increased 27.19 19.16 8 12099 260784 63216131
Malignant pleural effusion 26.71 19.16 12 12095 2594 63474321
Subarachnoid haemorrhage 26.70 19.16 22 12085 14261 63462654
Purpura 26.60 19.16 20 12087 11365 63465550
Lymphangiosis carcinomatosa 26.20 19.16 10 12097 1435 63475480
Concomitant disease aggravated 25.83 19.16 18 12089 9094 63467821
Haemoglobin decreased 25.45 19.16 73 12034 145412 63331503
Pneumocystis jirovecii pneumonia 25.42 19.16 23 12084 16891 63460024
Eczema 25.29 19.16 31 12076 32260 63444655
Tumour haemorrhage 25.02 19.16 10 12097 1621 63475294
Pleural effusion 24.96 19.16 55 12052 93155 63383760
Blood pressure decreased 24.17 19.16 44 12063 64978 63411937
Duodenal ulcer haemorrhage 24.15 19.16 11 12096 2456 63474459
Hyperuricaemia 23.65 19.16 14 12093 5356 63471559
Atypical femur fracture 23.64 19.16 14 12093 5358 63471557
Blood bilirubin increased 23.37 19.16 32 12075 37108 63439807
Physical deconditioning 23.37 19.16 8 12099 841 63476074
Enterocolitis viral 22.62 19.16 6 12101 263 63476652
Liver abscess 22.62 19.16 11 12096 2843 63474072
Hypersensitivity 22.52 19.16 14 12093 292671 63184244
Alopecia 22.27 19.16 19 12088 337517 63139398
Osteomyelitis 22.04 19.16 26 12081 25994 63450921
Melaena 21.94 19.16 28 12079 30337 63446578
Stomatitis 21.78 19.16 67 12040 138658 63338257
Lymphoproliferative disorder 21.46 19.16 11 12096 3179 63473736
Aortitis 21.44 19.16 8 12099 1079 63475836
Cancer pain 21.41 19.16 11 12096 3194 63473721
Subacute hepatic failure 21.26 19.16 5 12102 133 63476782
Delirium 21.11 19.16 36 12071 50505 63426410
Sinusitis 20.15 19.16 9 12098 226644 63250271
Malaise 19.59 19.16 141 11966 415813 63061102
Gamma-glutamyltransferase increased 19.45 19.16 28 12079 34003 63442912
Pneumonia 19.35 19.16 151 11956 456616 63020299
Asthenia 19.33 19.16 27 12080 383577 63093338
Familial mediterranean fever 19.18 19.16 4 12103 60 63476855

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Interstitial lung disease 455.17 17.50 272 10682 65010 34880967
Malignant neoplasm progression 233.16 17.50 204 10750 87842 34858135
Platelet count decreased 206.43 17.50 219 10735 119498 34826479
Hepatic function abnormal 202.64 17.50 142 10812 44221 34901756
White blood cell count decreased 116.01 17.50 146 10808 95299 34850678
Liver disorder 96.30 17.50 81 10873 32916 34913061
Neutrophil count decreased 94.04 17.50 97 10857 51007 34894970
Decreased appetite 84.89 17.50 171 10783 166221 34779756
Osteonecrosis of jaw 65.11 17.50 50 10904 17839 34928138
Drug ineffective 62.27 17.50 33 10921 456718 34489259
Stomatitis 61.28 17.50 71 10883 42443 34903534
Fatigue 56.30 17.50 23 10931 370630 34575347
Disseminated intravascular coagulation 54.43 17.50 49 10905 21767 34924210
Drug eruption 52.24 17.50 46 10908 19852 34926125
Renal impairment 49.10 17.50 98 10856 94415 34851562
Toxicity to various agents 47.93 17.50 4 10950 200358 34745619
Pyrexia 45.34 17.50 215 10739 332798 34613179
Radiation pneumonitis 44.55 17.50 20 10934 2620 34943357
Asthenia 42.76 17.50 12 10942 245239 34700738
Cholangitis 42.36 17.50 29 10925 8660 34937317
Anaemia 41.98 17.50 164 10790 233171 34712806
Drug-induced liver injury 41.27 17.50 48 10906 28784 34917193
Gastric ulcer haemorrhage 38.47 17.50 23 10931 5443 34940534
Delirium 37.78 17.50 57 10897 43934 34902043
Malaise 37.02 17.50 135 10819 185690 34760287
Aspartate aminotransferase increased 34.83 17.50 70 10884 67713 34878264
Gastrointestinal perforation 34.54 17.50 19 10935 3844 34942133
Altered state of consciousness 34.25 17.50 39 10915 22854 34923123
Confusional state 34.12 17.50 3 10951 144157 34801820
Erythema multiforme 33.28 17.50 25 10929 8624 34937353
Gastric ulcer 32.96 17.50 32 10922 15618 34930359
Upper respiratory tract inflammation 31.96 17.50 14 10940 1730 34944247
Hypothyroidism 30.24 17.50 35 10919 20867 34925110
Cerebral infarction 30.12 17.50 40 10914 27415 34918562
Lymphangiosis carcinomatosa 29.21 17.50 11 10943 921 34945056
Adrenocorticotropic hormone deficiency 29.04 17.50 11 10943 936 34945041
Non-small cell lung cancer 28.83 17.50 17 10937 3923 34942054
Pneumonia aspiration 28.72 17.50 49 10905 41854 34904123
Duodenal ulcer 27.34 17.50 24 10930 10308 34935669
Adrenal insufficiency 26.40 17.50 27 10927 14020 34931957
Pneumonia bacterial 26.37 17.50 25 10929 11847 34934130
Enterocolitis 26.10 17.50 21 10933 8005 34937972
Hyperuricaemia 26.06 17.50 21 10933 8022 34937955
Death 25.75 17.50 54 10900 397995 34547982
C-reactive protein increased 25.58 17.50 54 10900 54044 34891933
Blood bilirubin increased 25.21 17.50 44 10910 38252 34907725
Product dose omission issue 24.61 17.50 4 10950 119707 34826270
Alanine aminotransferase increased 23.59 17.50 67 10887 80748 34865229
Immune-mediated enterocolitis 22.93 17.50 13 10941 2786 34943191
Rash 22.73 17.50 133 10821 222619 34723358
Palmar-plantar erythrodysaesthesia syndrome 22.43 17.50 27 10927 16768 34929209
Hypoalbuminaemia 22.15 17.50 23 10931 12151 34933826
Prescribed underdose 22.14 17.50 20 10934 8913 34937064
Pharyngitis 22.12 17.50 19 10935 7925 34938052
Thrombophlebitis migrans 21.52 17.50 6 10948 191 34945786
Anxiety 21.17 17.50 3 10951 99425 34846552
Hepatocellular carcinoma 20.99 17.50 18 10936 7491 34938486
Cancer pain 20.79 17.50 12 10942 2660 34943317
Hypotension 20.05 17.50 24 10930 221625 34724352
Blood lactate dehydrogenase increased 20.02 17.50 30 10924 22960 34923017
Infective spondylitis 19.90 17.50 6 10948 253 34945724
Peritonitis 19.75 17.50 25 10929 16340 34929637
Haemorrhage subcutaneous 19.60 17.50 11 10943 2313 34943664
Duodenal perforation 19.42 17.50 9 10945 1269 34944708
Rhinitis allergic 19.32 17.50 12 10942 3038 34942939
Pneumonia 19.04 17.50 185 10769 362442 34583535
Eosinophil count increased 18.94 17.50 18 10936 8554 34937423
Colon cancer 18.85 17.50 18 10936 8603 34937374
Dyspnoea 18.30 17.50 59 10895 376723 34569254
Constipation 18.19 17.50 88 10866 136894 34809083
Paralysis recurrent laryngeal nerve 18.11 17.50 4 10950 47 34945930
Spinal compression fracture 17.77 17.50 16 10938 7100 34938877

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Interstitial lung disease 734.23 16.04 441 23196 112159 79608592
Platelet count decreased 512.64 16.04 439 23198 194225 79526526
Malignant neoplasm progression 408.04 16.04 331 23306 135659 79585092
Hepatic function abnormal 401.45 16.04 257 23380 72850 79647901
White blood cell count decreased 244.87 16.04 290 23347 187998 79532753
Neutrophil count decreased 236.75 16.04 207 23430 93752 79626999
Osteonecrosis of jaw 179.70 16.04 128 23509 43098 79677653
Fatigue 159.56 16.04 40 23597 929687 78791064
Disseminated intravascular coagulation 153.28 16.04 108 23529 35734 79685017
Decreased appetite 152.29 16.04 322 23315 342096 79378655
Anaemia 147.88 16.04 373 23264 444642 79276109
Drug ineffective 146.80 16.04 69 23568 1080844 78639907
Drug eruption 137.94 16.04 110 23527 43825 79676926
Liver disorder 129.49 16.04 132 23505 72285 79648466
Pyrexia 100.47 16.04 432 23205 678277 79042474
Gastrointestinal perforation 98.04 16.04 44 23593 6093 79714658
Cerebral infarction 97.96 16.04 92 23545 45584 79675167
Renal impairment 96.49 16.04 170 23467 157613 79563138
Erythema multiforme 91.67 16.04 60 23577 17591 79703160
Upper respiratory tract inflammation 87.79 16.04 36 23601 3999 79716752
Drug-induced liver injury 86.00 16.04 102 23535 66015 79654736
Enterocolitis 81.95 16.04 52 23585 14460 79706291
Spinal compression fracture 81.67 16.04 55 23582 16903 79703848
Altered state of consciousness 80.34 16.04 81 23556 43741 79677010
Confusional state 77.79 16.04 4 23633 317993 79402758
Toxicity to various agents 76.32 16.04 16 23621 421524 79299227
Stomatitis 67.34 16.04 140 23497 146617 79574134
Asthenia 67.12 16.04 34 23603 511655 79209096
Pneumonia bacterial 66.27 16.04 51 23586 19280 79701471
Haemorrhage subcutaneous 62.84 16.04 30 23607 4779 79715972
Aspartate aminotransferase increased 62.14 16.04 131 23506 138510 79582241
Joint swelling 61.17 16.04 7 23630 288639 79432112
Hypoalbuminaemia 59.83 16.04 50 23587 21247 79699504
Febrile neutropenia 57.93 16.04 175 23462 230824 79489927
Completed suicide 57.34 16.04 4 23633 245763 79474988
Drug intolerance 56.99 16.04 6 23631 264113 79456638
Drug hypersensitivity 56.92 16.04 10 23627 298906 79421845
Cardiac failure 55.64 16.04 134 23503 154708 79566043
Product dose omission issue 55.04 16.04 5 23632 247532 79473219
Pain 54.24 16.04 78 23559 703724 79017027
Cholangitis 53.44 16.04 38 23599 12738 79708013
Lymphangiosis carcinomatosa 53.01 16.04 21 23616 2133 79718618
Radiation pneumonitis 52.82 16.04 25 23612 3908 79716843
Delirium 52.74 16.04 92 23545 84535 79636216
Pharyngitis 51.70 16.04 47 23590 22328 79698423
Peripheral swelling 51.37 16.04 9 23628 269608 79451143
Peritonitis 49.88 16.04 51 23586 27985 79692766
Hyperuricaemia 49.14 16.04 35 23602 11764 79708987
Colon cancer 46.92 16.04 37 23600 14486 79706265
Gastric ulcer 46.89 16.04 54 23583 33851 79686900
Non-small cell lung cancer 46.77 16.04 27 23610 6333 79714418
Blood bilirubin increased 46.57 16.04 76 23561 66156 79654595
Fulminant type 1 diabetes mellitus 45.58 16.04 17 23620 1466 79719285
Alanine aminotransferase increased 44.39 16.04 127 23510 162443 79558308
Enteritis infectious 44.16 16.04 21 23616 3317 79717434
Adrenocorticotropic hormone deficiency 43.02 16.04 16 23621 1369 79719382
Femoral neck fracture 42.46 16.04 30 23607 9954 79710797
Hypotension 42.21 16.04 41 23596 440276 79280475
Ileus 41.84 16.04 45 23592 26166 79694585
Swelling 41.79 16.04 7 23630 216704 79504047
Malaise 41.15 16.04 267 23370 489602 79231149
Hypopituitarism 40.78 16.04 20 23617 3379 79717372
Dyspnoea 40.74 16.04 125 23512 856900 78863851
Pneumonia 40.65 16.04 334 23303 659912 79060839
Cancer pain 40.53 16.04 23 23614 5222 79715529
Gastric ulcer haemorrhage 40.43 16.04 28 23609 8999 79711752
Tumour haemorrhage 39.85 16.04 21 23616 4123 79716628
Herpes zoster 38.30 16.04 85 23552 92998 79627753
Arthropathy 38.25 16.04 4 23633 177107 79543644
Pleural effusion 38.23 16.04 112 23525 145150 79575601
Pneumonia aspiration 38.13 16.04 70 23567 66897 79653854
Iron deficiency anaemia 37.38 16.04 42 23595 25630 79695121
Therapeutic product effect decreased 37.26 16.04 3 23634 163860 79556891
Adrenal insufficiency 37.10 16.04 44 23593 28443 79692308
Drug abuse 36.94 16.04 3 23634 162688 79558063
Asteatosis 36.06 16.04 8 23629 102 79720649
Weight increased 35.47 16.04 19 23618 277367 79443384
Malignant pleural effusion 35.00 16.04 18 23619 3362 79717389
Hypersensitivity 34.97 16.04 17 23620 262222 79458529
Renal disorder 34.72 16.04 52 23585 42053 79678698
Pulmonary alveolar haemorrhage 34.48 16.04 28 23609 11429 79709322
Constipation 34.11 16.04 170 23467 282880 79437871
Pneumocystis jirovecii pneumonia 34.02 16.04 45 23592 32463 79688288
Gastroenteritis 33.86 16.04 46 23591 34036 79686715
Pain in extremity 33.71 16.04 35 23602 364503 79356248
Stevens-Johnson syndrome 33.20 16.04 49 23588 39117 79681634
Haemoglobin decreased 32.34 16.04 141 23496 221978 79498773
Duodenal ulcer 31.36 16.04 31 23606 16338 79704413
Gamma-glutamyltransferase increased 30.92 16.04 57 23580 54623 79666128
Eczema 30.28 16.04 48 23589 40770 79679981
Lymphocyte count decreased 30.22 16.04 52 23585 47237 79673514
Paronychia 29.87 16.04 22 23615 7786 79712965
Duodenal perforation 29.76 16.04 14 23623 2158 79718593
Immune-mediated enterocolitis 29.01 16.04 18 23619 4812 79715939
Anxiety 28.98 16.04 19 23618 248493 79472258
Hypothyroidism 28.86 16.04 54 23583 52338 79668413
C-reactive protein increased 28.84 16.04 94 23543 128933 79591818
Weight decreased 28.66 16.04 38 23599 355160 79365591
Hypocalcaemia 28.18 16.04 52 23585 49872 79670879
Cerebrovascular accident 27.84 16.04 6 23631 155286 79565465
Injection site dermatitis 27.78 16.04 5 23632 19 79720732
Liver abscess 27.64 16.04 19 23618 6035 79714716
Blood lactate dehydrogenase increased 27.60 16.04 45 23592 39125 79681626
Haemolytic anaemia 27.40 16.04 30 23607 17790 79702961
Hepatocellular carcinoma 27.05 16.04 22 23615 8999 79711752
Rhinitis allergic 26.84 16.04 25 23612 12244 79708507
Pneumothorax 26.29 16.04 37 23600 28286 79692465
Palmar-plantar erythrodysaesthesia syndrome 26.01 16.04 40 23597 33094 79687657
Paraesthesia 25.76 16.04 10 23627 176313 79544438
Prescribed underdose 25.12 16.04 37 23600 29477 79691274
Thrombophlebitis migrans 24.94 16.04 8 23629 439 79720312
Small intestine ulcer 24.90 16.04 9 23628 710 79720041
Syncope 24.89 16.04 11 23626 179438 79541313
Dyslalia 24.81 16.04 10 23627 1062 79719689
Arthralgia 24.62 16.04 87 23550 571716 79149035
Headache 24.61 16.04 105 23532 653667 79067084
Off label use 24.55 16.04 163 23474 907052 78813699
Breast cancer 24.06 16.04 39 23598 33742 79687009
Infective spondylitis 23.84 16.04 8 23629 506 79720245
KL-6 increased 23.05 16.04 6 23631 155 79720596
Heart rate increased 23.04 16.04 4 23633 120720 79600031
Heat illness 22.94 16.04 8 23629 569 79720182
Blood urea increased 22.88 16.04 47 23590 48743 79672008
Skin erosion 22.81 16.04 15 23622 4430 79716321
Eczema asteatotic 22.55 16.04 8 23629 598 79720153
Ascites 22.55 16.04 61 23576 75501 79645250
Blood creatine phosphokinase increased 22.44 16.04 56 23581 66034 79654717
Melaena 22.17 16.04 53 23584 60837 79659914
Tumour necrosis 22.14 16.04 11 23626 1911 79718840
Product use in unapproved indication 22.06 16.04 25 23612 250334 79470417
Sudden hearing loss 21.89 16.04 11 23626 1958 79718793
Wound 21.85 16.04 4 23633 116175 79604576
Enterocolitis viral 21.79 16.04 7 23630 386 79720365
Diverticulum intestinal haemorrhagic 21.72 16.04 14 23623 3997 79716754
Concomitant disease aggravated 21.71 16.04 23 23614 13144 79707607
Small intestinal perforation 21.62 16.04 13 23624 3284 79717467
Rash 21.60 16.04 264 23373 578094 79142657
Chronic gastritis 21.54 16.04 14 23623 4054 79716697
Large intestine perforation 21.49 16.04 24 23613 14543 79706208
Cholangitis acute 21.38 16.04 10 23627 1522 79719229
Pyelonephritis 20.99 16.04 28 23609 20360 79700391
Chest pain 20.98 16.04 32 23605 282272 79438479
Atypical femur fracture 20.71 16.04 15 23622 5174 79715577
Death 20.69 16.04 92 23545 566422 79154329
Duodenal ulcer haemorrhage 20.49 16.04 17 23620 7146 79713605
Rheumatoid arthritis 20.42 16.04 19 23618 208451 79512300
Pulmonary toxicity 20.31 16.04 22 23615 12892 79707859
Periodontitis 20.26 16.04 14 23623 4482 79716269
Blood pressure decreased 20.05 16.04 70 23567 99396 79621355
Shock haemorrhagic 19.81 16.04 27 23610 20033 79700718
Lymphoproliferative disorder 19.65 16.04 15 23622 5600 79715151
Blood alkaline phosphatase increased 19.60 16.04 52 23585 63612 79657139
Musculoskeletal stiffness 19.57 16.04 14 23623 174994 79545757
Osteomyelitis 19.52 16.04 35 23602 32830 79687921
Metastases to liver 19.23 16.04 32 23605 28282 79692469
Sinusitis 18.94 16.04 18 23619 195483 79525268
Memory impairment 18.68 16.04 5 23632 111729 79609022
Oculomucocutaneous syndrome 18.64 16.04 6 23631 333 79720418
Discomfort 18.55 16.04 7 23630 125610 79595141
Physical deconditioning 18.53 16.04 10 23627 2060 79718691
Aortitis 18.48 16.04 9 23628 1498 79719253
Alopecia 18.39 16.04 25 23612 231330 79489421
Meningitis 18.08 16.04 18 23619 9564 79711187
Immune-mediated hepatic disorder 18.00 16.04 9 23628 1585 79719166
Mobility decreased 17.73 16.04 7 23630 122168 79598583
Familial mediterranean fever 17.57 16.04 5 23632 182 79720569
Lupus nephritis 17.53 16.04 11 23626 2997 79717754
Nephrotic syndrome 17.51 16.04 19 23618 11155 79709596
Dermatitis acneiform 17.45 16.04 18 23619 9975 79710776
Product use issue 17.37 16.04 22 23615 209800 79510951
Malignant ascites 17.31 16.04 8 23629 1184 79719567
Hyperhidrosis 17.09 16.04 12 23625 151480 79569271
Subarachnoid haemorrhage 17.09 16.04 28 23609 24437 79696314
General physical health deterioration 17.01 16.04 35 23602 275203 79445548
Pleurisy 16.74 16.04 18 23619 10457 79710294
Wheezing 16.42 16.04 7 23630 116657 79604094
Loss of personal independence in daily activities 16.39 16.04 5 23632 102575 79618176
Colony stimulating factor therapy 16.08 16.04 6 23631 518 79720233

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M02AA31 MUSCULO-SKELETAL SYSTEM
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Antiinflammatory preparations, non-steroids for topical use
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory agent
CHEBI has role CHEBI:35493 anti-pyretic
CHEBI has role CHEBI:35544 cyclooxygenase inhibitors
CHEBI has role CHEBI:50266 Prodrugs

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Rheumatoid arthritis indication 69896004 DOID:7148




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.37 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 5 CHEMBL KEGG DRUG
Prostaglandin G/H synthase 1 Enzyme INHIBITOR IC50 5.19 CHEMBL KEGG DRUG

External reference:

IDSource
D08149 KEGG_DRUG
C0065199 UMLSCUI
CHEBI:31786 CHEBI
CHEMBL19299 ChEMBL_ID
DB09212 DRUGBANK_ID
C040656 MESH_SUPPLEMENTAL_RECORD_UI
3965 PUBCHEM_CID
5410 INN_ID
80382-23-6 SECONDARY_CAS_RN
3583H0GZAP UNII
28908 RXNORM
008162 NDDF
18991000122102 SNOMEDCT_US
CHEMBL66552 ChEMBL_ID

Pharmaceutical products:

None