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loxoprofen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| anti-inflammatory agents, ibuprofen derivatives | 1615 | 68767-14-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,BRAF,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,ITK,MAPK7,PDK1,PDK2,PDK4,PRKDC | 14 | |||
| kinase-selectivity-class | AXL,EIF2AK3,GRK2 | 3 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 23, 2006 | PMDA | Lead Chemical Co., Ltd. |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Platelet count decreased | 391.27 | 19.37 | 251 | 13847 | 136718 | 90477631 |
| Interstitial lung disease | 383.43 | 19.37 | 202 | 13896 | 76203 | 90538146 |
| Hepatic function abnormal | 277.34 | 19.37 | 138 | 13960 | 46150 | 90568199 |
| Neutrophil count decreased | 201.19 | 19.37 | 130 | 13968 | 71402 | 90542947 |
| Malignant neoplasm progression | 195.02 | 19.37 | 149 | 13949 | 106721 | 90507628 |
| Osteonecrosis of jaw | 158.82 | 19.37 | 90 | 14008 | 39013 | 90575336 |
| Anaemia | 156.99 | 19.37 | 231 | 13867 | 352571 | 90261778 |
| White blood cell count decreased | 148.34 | 19.37 | 155 | 13943 | 166954 | 90447395 |
| Drug eruption | 126.53 | 19.37 | 75 | 14023 | 35332 | 90579017 |
| Disseminated intravascular coagulation | 116.58 | 19.37 | 60 | 14038 | 21478 | 90592871 |
| Cerebral infarction | 112.82 | 19.37 | 63 | 14035 | 26533 | 90587816 |
| Fatigue | 104.13 | 19.37 | 26 | 14072 | 1153997 | 89460352 |
| Erythema multiforme | 102.45 | 19.37 | 46 | 14052 | 12200 | 90602149 |
| Decreased appetite | 99.98 | 19.37 | 196 | 13902 | 376344 | 90238005 |
| Drug ineffective | 93.31 | 19.37 | 50 | 14048 | 1384248 | 89230101 |
| Gastrointestinal perforation | 92.24 | 19.37 | 32 | 14066 | 4300 | 90610049 |
| Altered state of consciousness | 90.28 | 19.37 | 58 | 14040 | 31474 | 90582875 |
| Spinal compression fracture | 87.13 | 19.37 | 44 | 14054 | 15134 | 90599215 |
| Renal impairment | 83.26 | 19.37 | 92 | 14006 | 105329 | 90509020 |
| Pyrexia | 78.54 | 19.37 | 253 | 13845 | 660232 | 89954117 |
| Enterocolitis | 77.05 | 19.37 | 36 | 14062 | 10454 | 90603895 |
| Cardiac failure | 73.72 | 19.37 | 88 | 14010 | 109408 | 90504941 |
| Upper respiratory tract inflammation | 69.74 | 19.37 | 23 | 14075 | 2649 | 90611700 |
| Febrile neutropenia | 69.21 | 19.37 | 103 | 13995 | 158246 | 90456103 |
| Hypoalbuminaemia | 65.62 | 19.37 | 37 | 14061 | 15860 | 90598489 |
| Joint swelling | 62.59 | 19.37 | 4 | 14094 | 503296 | 90111053 |
| Drug intolerance | 57.35 | 19.37 | 3 | 14095 | 447588 | 90166761 |
| Pneumonia bacterial | 56.15 | 19.37 | 31 | 14067 | 12759 | 90601590 |
| Iron deficiency anaemia | 54.43 | 19.37 | 38 | 14060 | 23624 | 90590725 |
| Lymphocyte count decreased | 49.25 | 19.37 | 42 | 14056 | 35008 | 90579341 |
| Drug hypersensitivity | 48.94 | 19.37 | 7 | 14091 | 463602 | 90150747 |
| Ileus | 48.75 | 19.37 | 31 | 14067 | 16515 | 90597834 |
| Aspartate aminotransferase increased | 47.90 | 19.37 | 69 | 14029 | 102868 | 90511481 |
| Peripheral swelling | 46.62 | 19.37 | 5 | 14093 | 413101 | 90201248 |
| Peritonitis | 46.15 | 19.37 | 32 | 14066 | 19673 | 90594676 |
| Haemorrhage subcutaneous | 46.05 | 19.37 | 18 | 14080 | 3378 | 90610971 |
| Drug-induced liver injury | 45.67 | 19.37 | 63 | 14035 | 90255 | 90524094 |
| Femoral neck fracture | 45.46 | 19.37 | 25 | 14073 | 10208 | 90604141 |
| Ascites | 45.37 | 19.37 | 46 | 14052 | 47694 | 90566655 |
| Swelling | 45.00 | 19.37 | 6 | 14092 | 419052 | 90195297 |
| Enteritis infectious | 44.28 | 19.37 | 16 | 14082 | 2419 | 90611930 |
| Pain | 43.37 | 19.37 | 55 | 14043 | 996286 | 89618063 |
| Alanine aminotransferase increased | 42.00 | 19.37 | 70 | 14028 | 118268 | 90496081 |
| Herpes zoster | 41.94 | 19.37 | 62 | 14036 | 94582 | 90519767 |
| Pulmonary toxicity | 40.06 | 19.37 | 24 | 14074 | 11507 | 90602842 |
| Pneumocystis jirovecii pneumonia | 39.04 | 19.37 | 30 | 14068 | 21586 | 90592763 |
| Gastroenteritis | 38.98 | 19.37 | 34 | 14064 | 29195 | 90585154 |
| Contraindicated product administered | 38.45 | 19.37 | 3 | 14095 | 320136 | 90294213 |
| Atypical femur fracture | 37.98 | 19.37 | 19 | 14079 | 6402 | 90607947 |
| Fulminant type 1 diabetes mellitus | 37.42 | 19.37 | 11 | 14087 | 867 | 90613482 |
| Subarachnoid haemorrhage | 37.14 | 19.37 | 27 | 14071 | 17877 | 90596472 |
| Immune-mediated enterocolitis | 37.03 | 19.37 | 17 | 14081 | 4740 | 90609609 |
| Stevens-Johnson syndrome | 36.84 | 19.37 | 33 | 14065 | 29343 | 90585006 |
| Pharyngitis | 36.48 | 19.37 | 29 | 14069 | 21918 | 90592431 |
| Colon cancer | 36.02 | 19.37 | 22 | 14076 | 10922 | 90603427 |
| Blood pressure decreased | 36.01 | 19.37 | 51 | 14047 | 74844 | 90539505 |
| Melaena | 35.77 | 19.37 | 35 | 14063 | 34762 | 90579587 |
| Haemoglobin decreased | 35.44 | 19.37 | 78 | 14020 | 161878 | 90452471 |
| Physical deconditioning | 34.43 | 19.37 | 13 | 14085 | 2222 | 90612127 |
| Pleural effusion | 34.20 | 19.37 | 62 | 14036 | 111929 | 90502420 |
| Breast cancer | 34.19 | 19.37 | 42 | 14056 | 53719 | 90560630 |
| Paronychia | 34.03 | 19.37 | 19 | 14079 | 7987 | 90606362 |
| Pulmonary alveolar haemorrhage | 33.29 | 19.37 | 17 | 14081 | 5981 | 90608368 |
| Asteatosis | 32.33 | 19.37 | 6 | 14092 | 59 | 90614290 |
| Dyslalia | 30.62 | 19.37 | 9 | 14089 | 709 | 90613640 |
| Osteomyelitis | 30.49 | 19.37 | 29 | 14069 | 27817 | 90586532 |
| Palmar-plantar erythrodysaesthesia syndrome | 30.34 | 19.37 | 29 | 14069 | 27994 | 90586355 |
| Alopecia | 30.16 | 19.37 | 20 | 14078 | 495051 | 90119298 |
| Renal disorder | 29.79 | 19.37 | 33 | 14065 | 37826 | 90576523 |
| Weight increased | 29.61 | 19.37 | 14 | 14084 | 417913 | 90196436 |
| Blood creatine phosphokinase increased | 29.11 | 19.37 | 31 | 14067 | 33992 | 90580357 |
| Hyperuricaemia | 28.71 | 19.37 | 16 | 14082 | 6703 | 90607646 |
| Malaise | 28.60 | 19.37 | 172 | 13926 | 585814 | 90028535 |
| Dehydration | 28.14 | 19.37 | 80 | 14018 | 194367 | 90419982 |
| Heat illness | 28.01 | 19.37 | 7 | 14091 | 298 | 90614051 |
| Purpura | 27.77 | 19.37 | 21 | 14077 | 14757 | 90599592 |
| Malignant pleural effusion | 27.58 | 19.37 | 12 | 14086 | 2952 | 90611397 |
| Toxic encephalopathy | 27.38 | 19.37 | 17 | 14081 | 8682 | 90605667 |
| Enterocolitis viral | 26.91 | 19.37 | 7 | 14091 | 350 | 90613999 |
| Pyelonephritis | 26.84 | 19.37 | 24 | 14074 | 21292 | 90593057 |
| Lymphangiosis carcinomatosa | 26.76 | 19.37 | 10 | 14088 | 1662 | 90612687 |
| Hypothyroidism | 26.76 | 19.37 | 37 | 14061 | 53090 | 90561259 |
| Hypopituitarism | 26.30 | 19.37 | 10 | 14088 | 1743 | 90612606 |
| Immune-mediated hepatic disorder | 26.08 | 19.37 | 10 | 14088 | 1782 | 90612567 |
| Mobility decreased | 25.94 | 19.37 | 4 | 14094 | 250730 | 90363619 |
| Duodenal ulcer haemorrhage | 25.92 | 19.37 | 11 | 14087 | 2545 | 90611804 |
| Constipation | 25.87 | 19.37 | 99 | 13999 | 280296 | 90334053 |
| Liver abscess | 25.68 | 19.37 | 12 | 14086 | 3484 | 90610865 |
| Familial mediterranean fever | 25.66 | 19.37 | 5 | 14093 | 65 | 90614284 |
| Hypersensitivity | 25.56 | 19.37 | 20 | 14078 | 454657 | 90159692 |
| Concomitant disease aggravated | 25.33 | 19.37 | 18 | 14080 | 11500 | 90602849 |
| Gastric ulcer | 25.26 | 19.37 | 26 | 14072 | 27422 | 90586927 |
| Liver disorder | 24.95 | 19.37 | 57 | 14041 | 121212 | 90493137 |
| Tumour haemorrhage | 24.57 | 19.37 | 10 | 14088 | 2084 | 90612265 |
| Blood bilirubin increased | 24.53 | 19.37 | 32 | 14066 | 43438 | 90570911 |
| Pericarditis | 24.39 | 19.37 | 6 | 14092 | 270145 | 90344204 |
| Abdominal discomfort | 24.39 | 19.37 | 23 | 14075 | 477305 | 90137044 |
| Sinusitis | 23.52 | 19.37 | 12 | 14086 | 343076 | 90271273 |
| Product use issue | 23.44 | 19.37 | 11 | 14087 | 329908 | 90284441 |
| Lymphoproliferative disorder | 23.42 | 19.37 | 12 | 14086 | 4250 | 90610099 |
| Large intestine perforation | 23.28 | 19.37 | 16 | 14082 | 9696 | 90604653 |
| Depressed level of consciousness | 23.11 | 19.37 | 41 | 14057 | 72743 | 90541606 |
| Gamma-glutamyltransferase increased | 23.08 | 19.37 | 29 | 14069 | 37923 | 90576426 |
| Discomfort | 23.07 | 19.37 | 7 | 14091 | 274328 | 90340021 |
| Systemic lupus erythematosus | 22.88 | 19.37 | 14 | 14084 | 361882 | 90252467 |
| Psoriatic arthropathy | 22.82 | 19.37 | 4 | 14094 | 228331 | 90386018 |
| Gastrointestinal disorder | 22.60 | 19.37 | 6 | 14092 | 256681 | 90357668 |
| Cholangitis | 22.52 | 19.37 | 14 | 14084 | 7168 | 90607181 |
| Subacute hepatic failure | 22.50 | 19.37 | 5 | 14093 | 127 | 90614222 |
| Small intestinal perforation | 21.91 | 19.37 | 9 | 14089 | 1920 | 90612429 |
| Rheumatoid arthritis | 21.60 | 19.37 | 15 | 14083 | 362599 | 90251750 |
| Femur fracture | 21.58 | 19.37 | 31 | 14067 | 46051 | 90568298 |
| Aortitis | 21.33 | 19.37 | 8 | 14090 | 1342 | 90613007 |
| Cancer pain | 21.16 | 19.37 | 11 | 14087 | 4014 | 90610335 |
| Eczema | 21.10 | 19.37 | 33 | 14065 | 52837 | 90561512 |
| Cerebral haemorrhage | 20.39 | 19.37 | 26 | 14072 | 34496 | 90579853 |
| Blood cholesterol increased | 20.02 | 19.37 | 4 | 14094 | 208008 | 90406341 |
| Malignant ascites | 20.00 | 19.37 | 7 | 14091 | 965 | 90613384 |
| Shock haemorrhagic | 19.96 | 19.37 | 16 | 14082 | 12229 | 90602120 |
| Pneumonia | 19.84 | 19.37 | 168 | 13930 | 637891 | 89976458 |
| Tumour necrosis | 19.80 | 19.37 | 7 | 14091 | 994 | 90613355 |
| Asthenia | 19.67 | 19.37 | 33 | 14065 | 533718 | 90080631 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Interstitial lung disease | 480.61 | 16.66 | 299 | 12809 | 78163 | 42530064 |
| Hepatic function abnormal | 221.85 | 16.66 | 158 | 12950 | 51409 | 42556818 |
| Malignant neoplasm progression | 216.61 | 16.66 | 213 | 12895 | 108187 | 42500040 |
| Platelet count decreased | 211.97 | 16.66 | 236 | 12872 | 138345 | 42469882 |
| White blood cell count decreased | 116.41 | 16.66 | 156 | 12952 | 110240 | 42497987 |
| Decreased appetite | 100.53 | 16.66 | 198 | 12910 | 192939 | 42415288 |
| Liver disorder | 96.37 | 16.66 | 87 | 13021 | 39557 | 42568670 |
| Neutrophil count decreased | 94.94 | 16.66 | 107 | 13001 | 63308 | 42544919 |
| Drug ineffective | 90.03 | 16.66 | 41 | 13067 | 630156 | 41978071 |
| Drug eruption | 73.16 | 16.66 | 59 | 13049 | 23016 | 42585211 |
| Osteonecrosis of jaw | 69.67 | 16.66 | 53 | 13055 | 18996 | 42589231 |
| Fatigue | 65.80 | 16.66 | 26 | 13082 | 435615 | 42172612 |
| Renal impairment | 64.61 | 16.66 | 119 | 12989 | 110109 | 42498118 |
| Disseminated intravascular coagulation | 61.38 | 16.66 | 55 | 13053 | 24739 | 42583488 |
| Pyrexia | 58.86 | 16.66 | 258 | 12850 | 393784 | 42214443 |
| Stomatitis | 57.39 | 16.66 | 74 | 13034 | 50255 | 42557972 |
| Cholangitis | 46.33 | 16.66 | 33 | 13075 | 10694 | 42597533 |
| Pancreatic abscess | 46.23 | 16.66 | 11 | 13097 | 187 | 42608040 |
| Radiation pneumonitis | 46.02 | 16.66 | 21 | 13087 | 2912 | 42605315 |
| Malaise | 44.67 | 16.66 | 155 | 12953 | 212001 | 42396226 |
| Gastric ulcer haemorrhage | 44.14 | 16.66 | 26 | 13082 | 6101 | 42602126 |
| Asthenia | 43.57 | 16.66 | 16 | 13092 | 280777 | 42327450 |
| Gastric ulcer | 42.24 | 16.66 | 39 | 13069 | 18223 | 42590004 |
| Aspartate aminotransferase increased | 41.07 | 16.66 | 80 | 13028 | 77083 | 42531144 |
| Confusional state | 40.10 | 16.66 | 3 | 13105 | 167594 | 42440633 |
| Cerebral infarction | 38.97 | 16.66 | 48 | 13060 | 31121 | 42577106 |
| Anaemia | 38.33 | 16.66 | 179 | 12929 | 280099 | 42328128 |
| Drug-induced liver injury | 37.09 | 16.66 | 52 | 13056 | 38221 | 42570006 |
| Non-small cell lung cancer | 35.55 | 16.66 | 21 | 13087 | 4953 | 42603274 |
| Lymphangiosis carcinomatosa | 35.53 | 16.66 | 13 | 13095 | 1024 | 42607203 |
| Delirium | 34.96 | 16.66 | 60 | 13048 | 52459 | 42555768 |
| Erythema multiforme | 34.81 | 16.66 | 27 | 13081 | 9950 | 42598277 |
| Pneumonia aspiration | 34.38 | 16.66 | 58 | 13050 | 50020 | 42558207 |
| C-reactive protein increased | 33.94 | 16.66 | 66 | 13042 | 63494 | 42544733 |
| Immune-mediated enterocolitis | 32.99 | 16.66 | 21 | 13087 | 5656 | 42602571 |
| Toxicity to various agents | 32.38 | 16.66 | 15 | 13093 | 229121 | 42379106 |
| Gastrointestinal perforation | 32.22 | 16.66 | 19 | 13089 | 4467 | 42603760 |
| Altered state of consciousness | 31.75 | 16.66 | 42 | 13066 | 29217 | 42579010 |
| Product dose omission issue | 31.29 | 16.66 | 5 | 13103 | 154360 | 42453867 |
| Upper respiratory tract inflammation | 31.09 | 16.66 | 14 | 13094 | 1882 | 42606345 |
| Enterocolitis | 30.64 | 16.66 | 25 | 13083 | 9904 | 42598323 |
| Adrenal insufficiency | 30.11 | 16.66 | 33 | 13075 | 18891 | 42589336 |
| Duodenal ulcer | 29.91 | 16.66 | 27 | 13081 | 12252 | 42595975 |
| Blood lactate dehydrogenase increased | 29.17 | 16.66 | 38 | 13070 | 26043 | 42582184 |
| Fulminant type 1 diabetes mellitus | 28.58 | 16.66 | 12 | 13096 | 1362 | 42606865 |
| Spinal compression fracture | 27.75 | 16.66 | 21 | 13087 | 7462 | 42600765 |
| Alanine aminotransferase increased | 27.37 | 16.66 | 74 | 13034 | 88332 | 42519895 |
| Hypothyroidism | 27.30 | 16.66 | 41 | 13067 | 32043 | 42576184 |
| Hypotension | 26.69 | 16.66 | 24 | 13084 | 257607 | 42350620 |
| Pneumonia bacterial | 26.08 | 16.66 | 28 | 13080 | 15664 | 42592563 |
| Hepatocellular carcinoma | 26.06 | 16.66 | 21 | 13087 | 8173 | 42600054 |
| Death | 25.69 | 16.66 | 68 | 13040 | 471117 | 42137110 |
| Adrenocorticotropic hormone deficiency | 25.31 | 16.66 | 11 | 13097 | 1359 | 42606868 |
| Blood bilirubin increased | 25.19 | 16.66 | 46 | 13062 | 42206 | 42566021 |
| Pulmonary toxicity | 25.05 | 16.66 | 21 | 13087 | 8634 | 42599593 |
| Pharyngitis | 24.56 | 16.66 | 21 | 13087 | 8869 | 42599358 |
| Rhinitis allergic | 24.31 | 16.66 | 15 | 13093 | 3827 | 42604400 |
| Peritonitis | 23.77 | 16.66 | 29 | 13079 | 18604 | 42589623 |
| Anxiety | 23.66 | 16.66 | 4 | 13104 | 118556 | 42489671 |
| Hyperuricaemia | 23.50 | 16.66 | 21 | 13087 | 9403 | 42598824 |
| Hypopituitarism | 23.19 | 16.66 | 13 | 13095 | 2778 | 42605449 |
| Off label use | 22.89 | 16.66 | 110 | 12998 | 638225 | 41970002 |
| Cancer pain | 22.75 | 16.66 | 14 | 13094 | 3553 | 42604674 |
| Pneumonia | 22.55 | 16.66 | 213 | 12895 | 421936 | 42186291 |
| Dyspnoea | 22.54 | 16.66 | 66 | 13042 | 442555 | 42165672 |
| Rash | 21.97 | 16.66 | 153 | 12955 | 276801 | 42331426 |
| Cholangitis sclerosing | 21.86 | 16.66 | 11 | 13097 | 1891 | 42606336 |
| Immune-mediated hepatic disorder | 21.68 | 16.66 | 12 | 13096 | 2502 | 42605725 |
| Haemorrhage subcutaneous | 21.11 | 16.66 | 12 | 13096 | 2634 | 42605593 |
| Colon cancer | 21.08 | 16.66 | 20 | 13088 | 9661 | 42598566 |
| Duodenal perforation | 20.34 | 16.66 | 10 | 13098 | 1636 | 42606591 |
| Prescribed underdose | 20.06 | 16.66 | 20 | 13088 | 10262 | 42597965 |
| Infective spondylitis | 19.90 | 16.66 | 6 | 13102 | 258 | 42607969 |
| Hypoalbuminaemia | 19.44 | 16.66 | 24 | 13084 | 15586 | 42592641 |
| Palmar-plantar erythrodysaesthesia syndrome | 18.51 | 16.66 | 27 | 13081 | 20555 | 42587672 |
| Thrombophlebitis migrans | 17.91 | 16.66 | 6 | 13102 | 364 | 42607863 |
| Completed suicide | 17.68 | 16.66 | 4 | 13104 | 96461 | 42511766 |
| Chronic gastritis | 17.63 | 16.66 | 10 | 13098 | 2187 | 42606040 |
| Tumour haemorrhage | 17.60 | 16.66 | 12 | 13096 | 3626 | 42604601 |
| Injection site dermatitis | 17.11 | 16.66 | 3 | 13105 | 9 | 42608218 |
| Product use in unapproved indication | 17 | 16.66 | 19 | 13089 | 184437 | 42423790 |
| Hypocalcaemia | 16.91 | 16.66 | 32 | 13076 | 30141 | 42578086 |
| Eczema asteatotic | 16.72 | 16.66 | 6 | 13102 | 447 | 42607780 |
| Pericarditis malignant | 16.70 | 16.66 | 4 | 13104 | 70 | 42608157 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Interstitial lung disease | 849.52 | 15.99 | 493 | 27307 | 138841 | 110422658 |
| Platelet count decreased | 600.41 | 15.99 | 482 | 27318 | 229961 | 110331538 |
| Hepatic function abnormal | 480.91 | 15.99 | 292 | 27508 | 89003 | 110472496 |
| Malignant neoplasm progression | 426.50 | 15.99 | 352 | 27448 | 174215 | 110387284 |
| Neutrophil count decreased | 280.86 | 15.99 | 237 | 27563 | 120704 | 110440795 |
| White blood cell count decreased | 271.91 | 15.99 | 311 | 27489 | 229079 | 110332420 |
| Osteonecrosis of jaw | 210.59 | 15.99 | 138 | 27662 | 47879 | 110513620 |
| Decreased appetite | 191.86 | 15.99 | 390 | 27410 | 475456 | 110086043 |
| Drug eruption | 182.83 | 15.99 | 132 | 27668 | 53527 | 110507972 |
| Disseminated intravascular coagulation | 174.59 | 15.99 | 116 | 27684 | 41170 | 110520329 |
| Anaemia | 173.44 | 15.99 | 407 | 27393 | 546679 | 110014820 |
| Drug ineffective | 168.05 | 15.99 | 87 | 27713 | 1520453 | 109041046 |
| Fatigue | 166.33 | 15.99 | 50 | 27750 | 1215908 | 109345591 |
| Renal impairment | 141.68 | 15.99 | 204 | 27596 | 188241 | 110373258 |
| Cerebral infarction | 131.48 | 15.99 | 107 | 27693 | 51731 | 110509768 |
| Pyrexia | 131.14 | 15.99 | 508 | 27292 | 897757 | 109663742 |
| Erythema multiforme | 123.80 | 15.99 | 73 | 27727 | 21024 | 110540475 |
| Gastrointestinal perforation | 116.11 | 15.99 | 50 | 27750 | 7406 | 110554093 |
| Spinal compression fracture | 103.64 | 15.99 | 62 | 27738 | 18330 | 110543169 |
| Altered state of consciousness | 100.16 | 15.99 | 96 | 27704 | 57530 | 110503969 |
| Enterocolitis | 99.37 | 15.99 | 61 | 27739 | 18888 | 110542611 |
| Confusional state | 97.25 | 15.99 | 5 | 27795 | 468675 | 110092824 |
| Upper respiratory tract inflammation | 94.24 | 15.99 | 37 | 27763 | 4334 | 110557165 |
| Liver disorder | 88.41 | 15.99 | 141 | 27659 | 142102 | 110419397 |
| Aspartate aminotransferase increased | 82.69 | 15.99 | 146 | 27654 | 159790 | 110401709 |
| Drug intolerance | 79.35 | 15.99 | 6 | 27794 | 406506 | 110154993 |
| Hypoalbuminaemia | 75.98 | 15.99 | 61 | 27739 | 28913 | 110532586 |
| Joint swelling | 75.04 | 15.99 | 11 | 27789 | 442834 | 110118665 |
| Pneumonia bacterial | 74.69 | 15.99 | 58 | 27742 | 26203 | 110535296 |
| Cardiac failure | 73.24 | 15.99 | 152 | 27648 | 187474 | 110374025 |
| Drug hypersensitivity | 73.09 | 15.99 | 13 | 27787 | 454077 | 110107422 |
| Asthenia | 69.21 | 15.99 | 44 | 27756 | 688955 | 109872544 |
| Peripheral swelling | 68.54 | 15.99 | 10 | 27790 | 404024 | 110157475 |
| Drug-induced liver injury | 66.48 | 15.99 | 113 | 27687 | 119954 | 110441545 |
| Peritonitis | 65.70 | 15.99 | 59 | 27741 | 32548 | 110528951 |
| Gastric ulcer | 64.79 | 15.99 | 64 | 27736 | 39763 | 110521736 |
| Cholangitis | 64.49 | 15.99 | 44 | 27756 | 16291 | 110545208 |
| Immune-mediated enterocolitis | 64.40 | 15.99 | 37 | 27763 | 10148 | 110551351 |
| Pain | 64.16 | 15.99 | 88 | 27712 | 954867 | 109606632 |
| Pulmonary toxicity | 63.50 | 15.99 | 45 | 27755 | 17701 | 110543798 |
| Febrile neutropenia | 62.24 | 15.99 | 198 | 27602 | 316569 | 110244930 |
| Fulminant type 1 diabetes mellitus | 61.70 | 15.99 | 23 | 27777 | 2340 | 110559159 |
| Alanine aminotransferase increased | 61.58 | 15.99 | 140 | 27660 | 183633 | 110377866 |
| Swelling | 61.16 | 15.99 | 8 | 27792 | 351033 | 110210466 |
| Lymphangiosis carcinomatosa | 60.60 | 15.99 | 23 | 27777 | 2459 | 110559040 |
| Haemorrhage subcutaneous | 60.46 | 15.99 | 29 | 27771 | 5510 | 110555989 |
| Pharyngitis | 59.85 | 15.99 | 50 | 27750 | 25048 | 110536451 |
| Arthropathy | 59.82 | 15.99 | 3 | 27797 | 287519 | 110273980 |
| Product dose omission issue | 59.38 | 15.99 | 6 | 27794 | 321776 | 110239723 |
| Pneumonia aspiration | 58.15 | 15.99 | 86 | 27714 | 81147 | 110480352 |
| Colon cancer | 57.23 | 15.99 | 41 | 27759 | 16402 | 110545097 |
| Radiation pneumonitis | 56.45 | 15.99 | 26 | 27774 | 4510 | 110556989 |
| Non-small cell lung cancer | 56.06 | 15.99 | 31 | 27769 | 7904 | 110553595 |
| Gastric ulcer haemorrhage | 54.21 | 15.99 | 33 | 27767 | 10061 | 110551438 |
| Ileus | 53.02 | 15.99 | 51 | 27749 | 30678 | 110530821 |
| Malaise | 52.53 | 15.99 | 318 | 27482 | 671501 | 109889998 |
| Hyperuricaemia | 52.34 | 15.99 | 37 | 27763 | 14494 | 110547005 |
| Blood bilirubin increased | 50.92 | 15.99 | 78 | 27722 | 75894 | 110485605 |
| Pneumocystis jirovecii pneumonia | 50.58 | 15.99 | 58 | 27742 | 42677 | 110518822 |
| Femoral neck fracture | 49.96 | 15.99 | 34 | 27766 | 12533 | 110548966 |
| Iron deficiency anaemia | 48.18 | 15.99 | 49 | 27751 | 31510 | 110529989 |
| Hypopituitarism | 47.96 | 15.99 | 23 | 27777 | 4367 | 110557132 |
| Hypersensitivity | 47.58 | 15.99 | 21 | 27779 | 403977 | 110157522 |
| Renal disorder | 46.89 | 15.99 | 60 | 27740 | 49419 | 110512080 |
| Pneumonia | 46.77 | 15.99 | 378 | 27422 | 876336 | 109685163 |
| Therapeutic product effect decreased | 46.55 | 15.99 | 4 | 27796 | 244312 | 110317187 |
| Hypothyroidism | 46.28 | 15.99 | 73 | 27727 | 72826 | 110488673 |
| Herpes zoster | 46.07 | 15.99 | 91 | 27709 | 108288 | 110453211 |
| Adrenal insufficiency | 45.96 | 15.99 | 55 | 27745 | 42335 | 110519164 |
| Contraindicated product administered | 44.85 | 15.99 | 5 | 27795 | 248262 | 110313237 |
| Gastroenteritis | 44.81 | 15.99 | 52 | 27748 | 38748 | 110522751 |
| Haemoglobin decreased | 44.81 | 15.99 | 151 | 27649 | 248576 | 110312923 |
| Immune-mediated hepatic disorder | 44.66 | 15.99 | 22 | 27778 | 4428 | 110557071 |
| Lymphocyte count decreased | 44.46 | 15.99 | 63 | 27737 | 57180 | 110504319 |
| Enteritis infectious | 44.43 | 15.99 | 21 | 27779 | 3861 | 110557638 |
| Pleural effusion | 44.35 | 15.99 | 121 | 27679 | 177588 | 110383911 |
| Cancer pain | 43.88 | 15.99 | 25 | 27775 | 6747 | 110554752 |
| Delirium | 43.16 | 15.99 | 101 | 27699 | 134924 | 110426575 |
| Dyspnoea | 42.43 | 15.99 | 140 | 27660 | 1106732 | 109454767 |
| Blood lactate dehydrogenase increased | 42.39 | 15.99 | 54 | 27746 | 44280 | 110517219 |
| Adrenocorticotropic hormone deficiency | 41.93 | 15.99 | 17 | 27783 | 2165 | 110559334 |
| Constipation | 41.47 | 15.99 | 189 | 27611 | 357597 | 110203902 |
| Tumour haemorrhage | 41.25 | 15.99 | 22 | 27778 | 5223 | 110556276 |
| Completed suicide | 41.08 | 15.99 | 6 | 27794 | 242375 | 110319124 |
| Palmar-plantar erythrodysaesthesia syndrome | 40.86 | 15.99 | 51 | 27749 | 40974 | 110520525 |
| Duodenal ulcer | 40.68 | 15.99 | 36 | 27764 | 19478 | 110542021 |
| Paraesthesia | 40.19 | 15.99 | 10 | 27790 | 276511 | 110284988 |
| Toxicity to various agents | 40.15 | 15.99 | 37 | 27763 | 480518 | 110080981 |
| Stomatitis | 40.10 | 15.99 | 154 | 27646 | 270088 | 110291411 |
| Stevens-Johnson syndrome | 40.00 | 15.99 | 54 | 27746 | 46847 | 110514652 |
| Hypotension | 39.59 | 15.99 | 44 | 27756 | 523805 | 110037694 |
| Off label use | 39.55 | 15.99 | 219 | 27581 | 1499966 | 109061533 |
| Weight increased | 39.15 | 15.99 | 29 | 27771 | 419615 | 110141884 |
| Blood creatine phosphokinase increased | 38.11 | 15.99 | 67 | 27733 | 73010 | 110488489 |
| Dyslalia | 37.95 | 15.99 | 14 | 27786 | 1383 | 110560116 |
| Pancreatic abscess | 37.69 | 15.99 | 9 | 27791 | 192 | 110561307 |
| Hepatocellular carcinoma | 37.55 | 15.99 | 26 | 27774 | 9854 | 110551645 |
| Wheezing | 37.54 | 15.99 | 9 | 27791 | 255221 | 110306278 |
| Anxiety | 37.48 | 15.99 | 20 | 27780 | 345058 | 110216441 |
| Wound | 37.07 | 15.99 | 7 | 27793 | 234430 | 110327069 |
| Physical deconditioning | 37.04 | 15.99 | 18 | 27782 | 3519 | 110557980 |
| Product use in unapproved indication | 36.72 | 15.99 | 35 | 27765 | 447342 | 110114157 |
| Small intestinal perforation | 36.24 | 15.99 | 19 | 27781 | 4357 | 110557142 |
| Melaena | 35.80 | 15.99 | 63 | 27737 | 68694 | 110492805 |
| Liver abscess | 35.76 | 15.99 | 23 | 27777 | 7716 | 110553783 |
| Mobility decreased | 35.66 | 15.99 | 8 | 27792 | 237414 | 110324085 |
| Gamma-glutamyltransferase increased | 35.65 | 15.99 | 59 | 27741 | 61250 | 110500249 |
| Helicobacter infection | 34.58 | 15.99 | 3 | 27797 | 181874 | 110379625 |
| Malignant pleural effusion | 34.55 | 15.99 | 18 | 27782 | 4075 | 110557424 |
| Pulmonary alveolar haemorrhage | 33.92 | 15.99 | 33 | 27767 | 20117 | 110541382 |
| Pneumothorax | 33.77 | 15.99 | 43 | 27757 | 35242 | 110526257 |
| Type 2 diabetes mellitus | 33.49 | 15.99 | 3 | 27797 | 177229 | 110384270 |
| Alopecia | 33.00 | 15.99 | 26 | 27774 | 364727 | 110196772 |
| Hypocalcaemia | 32.89 | 15.99 | 59 | 27741 | 65307 | 110496192 |
| Pain in extremity | 32.51 | 15.99 | 45 | 27755 | 487073 | 110074426 |
| Ascites | 32.51 | 15.99 | 72 | 27728 | 92736 | 110468763 |
| Headache | 32.14 | 15.99 | 114 | 27686 | 882263 | 109679236 |
| Fibromyalgia | 32.01 | 15.99 | 3 | 27797 | 170906 | 110390593 |
| Duodenal perforation | 31.75 | 15.99 | 15 | 27785 | 2755 | 110558744 |
| Blood pressure decreased | 31.37 | 15.99 | 81 | 27719 | 115010 | 110446489 |
| Paronychia | 30.48 | 15.99 | 24 | 27776 | 11057 | 110550442 |
| Maternal exposure during pregnancy | 30.38 | 15.99 | 13 | 27787 | 254870 | 110306629 |
| Blood cholesterol increased | 30.34 | 15.99 | 5 | 27795 | 184780 | 110376719 |
| Atypical femur fracture | 30.02 | 15.99 | 19 | 27781 | 6200 | 110555299 |
| Asteatosis | 29.97 | 15.99 | 8 | 27792 | 271 | 110561228 |
| Chronic gastritis | 29.85 | 15.99 | 18 | 27782 | 5393 | 110556106 |
| Rhinitis allergic | 29.52 | 15.99 | 29 | 27771 | 17893 | 110543606 |
| Osteomyelitis | 29.49 | 15.99 | 41 | 27759 | 36559 | 110524940 |
| Large intestine perforation | 29.44 | 15.99 | 28 | 27772 | 16601 | 110544898 |
| Haemolytic anaemia | 29.27 | 15.99 | 31 | 27769 | 20889 | 110540610 |
| Discomfort | 28.89 | 15.99 | 9 | 27791 | 214698 | 110346801 |
| Femur fracture | 28.87 | 15.99 | 45 | 27755 | 44424 | 110517075 |
| Pericarditis | 28.06 | 15.99 | 10 | 27790 | 219104 | 110342395 |
| Musculoskeletal stiffness | 27.86 | 15.99 | 18 | 27782 | 279804 | 110281695 |
| Breast cancer | 27.85 | 15.99 | 41 | 27759 | 38501 | 110522998 |
| Gastrointestinal disorder | 27.80 | 15.99 | 13 | 27787 | 241939 | 110319560 |
| Nephrotic syndrome | 27.80 | 15.99 | 25 | 27775 | 13806 | 110547693 |
| Pyelonephritis | 27.76 | 15.99 | 33 | 27767 | 25217 | 110536282 |
| Abdominal discomfort | 27.69 | 15.99 | 35 | 27765 | 393823 | 110167676 |
| Metastases to liver | 27.56 | 15.99 | 39 | 27761 | 35347 | 110526152 |
| Cerebrovascular accident | 27.43 | 15.99 | 6 | 27794 | 181278 | 110380221 |
| Injection site dermatitis | 27.33 | 15.99 | 5 | 27795 | 26 | 110561473 |
| Memory impairment | 26.96 | 15.99 | 8 | 27792 | 196936 | 110364563 |
| Psoriatic arthropathy | 26.92 | 15.99 | 8 | 27792 | 196753 | 110364746 |
| Thyroiditis | 26.65 | 15.99 | 18 | 27782 | 6555 | 110554944 |
| Drug abuse | 26.59 | 15.99 | 6 | 27794 | 177405 | 110384094 |
| Eczema | 26.36 | 15.99 | 57 | 27743 | 72236 | 110489263 |
| Weight decreased | 25.82 | 15.99 | 49 | 27751 | 468008 | 110093491 |
| Dry mouth | 25.81 | 15.99 | 9 | 27791 | 199939 | 110361560 |
| Sinusitis | 25.77 | 15.99 | 22 | 27778 | 296666 | 110264833 |
| Irritable bowel syndrome | 25.75 | 15.99 | 5 | 27795 | 164210 | 110397289 |
| Thrombophlebitis migrans | 25.70 | 15.99 | 9 | 27791 | 765 | 110560734 |
| Blood urea increased | 25.62 | 15.99 | 48 | 27752 | 54909 | 110506590 |
| Heat illness | 25.50 | 15.99 | 9 | 27791 | 783 | 110560716 |
| Migraine | 25.34 | 15.99 | 6 | 27794 | 171646 | 110389853 |
| Eczema asteatotic | 25.15 | 15.99 | 9 | 27791 | 815 | 110560684 |
| Sudden hearing loss | 25.13 | 15.99 | 12 | 27788 | 2257 | 110559242 |
| Rheumatoid arthritis | 25.08 | 15.99 | 23 | 27777 | 299590 | 110261909 |
| General physical health deterioration | 24.82 | 15.99 | 43 | 27757 | 425252 | 110136247 |
| Infective spondylitis | 24.78 | 15.99 | 8 | 27792 | 530 | 110560969 |
| Small intestine ulcer | 24.67 | 15.99 | 9 | 27791 | 862 | 110560637 |
| Injury | 24.63 | 15.99 | 7 | 27793 | 177258 | 110384241 |
| Cerebral haemorrhage | 24.58 | 15.99 | 52 | 27748 | 64916 | 110496583 |
| Folliculitis | 24.47 | 15.99 | 6 | 27794 | 167647 | 110393852 |
| KL-6 increased | 24.41 | 15.99 | 7 | 27793 | 310 | 110561189 |
| Tumour necrosis | 24.32 | 15.99 | 12 | 27788 | 2424 | 110559075 |
| Therapy non-responder | 24.23 | 15.99 | 5 | 27795 | 157302 | 110404197 |
| Diverticulum intestinal haemorrhagic | 24.12 | 15.99 | 15 | 27785 | 4748 | 110556751 |
| Product use issue | 23.72 | 15.99 | 26 | 27774 | 311669 | 110249830 |
| Muscle spasms | 23.71 | 15.99 | 21 | 27779 | 278136 | 110283363 |
| Night sweats | 23.44 | 15.99 | 3 | 27797 | 133980 | 110427519 |
| Duodenal ulcer haemorrhage | 23.39 | 15.99 | 18 | 27782 | 8019 | 110553480 |
| Intentional product use issue | 23.27 | 15.99 | 17 | 27783 | 247889 | 110313610 |
| Meningitis | 23.22 | 15.99 | 21 | 27779 | 11681 | 110549818 |
| Syncope | 23.09 | 15.99 | 11 | 27789 | 202525 | 110358974 |
| Chest pain | 22.94 | 15.99 | 37 | 27763 | 376338 | 110185161 |
| Periodontitis | 22.89 | 15.99 | 15 | 27785 | 5193 | 110556306 |
| Immune-mediated lung disease | 22.65 | 15.99 | 15 | 27785 | 5288 | 110556211 |
| Loss of personal independence in daily activities | 22.63 | 15.99 | 5 | 27795 | 150015 | 110411484 |
| Cholangitis sclerosing | 22.61 | 15.99 | 13 | 27787 | 3569 | 110557930 |
| Blood alkaline phosphatase increased | 22.59 | 15.99 | 53 | 27747 | 70882 | 110490617 |
| Familial mediterranean fever | 22.51 | 15.99 | 6 | 27794 | 202 | 110561297 |
| C-reactive protein abnormal | 22.46 | 15.99 | 3 | 27797 | 129692 | 110431807 |
| C-reactive protein increased | 22.23 | 15.99 | 111 | 27689 | 217808 | 110343691 |
| Cellulitis | 22.22 | 15.99 | 76 | 27724 | 125940 | 110435559 |
| Metastases to bone | 22.13 | 15.99 | 33 | 27767 | 31339 | 110530160 |
| Subarachnoid haemorrhage | 22.05 | 15.99 | 32 | 27768 | 29670 | 110531829 |
| Small intestinal haemorrhage | 22.02 | 15.99 | 14 | 27786 | 4604 | 110556895 |
| Immune-mediated encephalitis | 21.94 | 15.99 | 9 | 27791 | 1181 | 110560318 |
| Systemic lupus erythematosus | 21.92 | 15.99 | 19 | 27781 | 254319 | 110307180 |
| Hyperkalaemia | 21.46 | 15.99 | 79 | 27721 | 135717 | 110425782 |
| Skin erosion | 21.30 | 15.99 | 15 | 27785 | 5839 | 110555660 |
| Tubulointerstitial nephritis | 21.18 | 15.99 | 44 | 27756 | 54240 | 110507259 |
| Enterocolitis viral | 20.92 | 15.99 | 8 | 27792 | 873 | 110560626 |
| Cholangitis acute | 20.83 | 15.99 | 10 | 27790 | 1903 | 110559596 |
| Concomitant disease aggravated | 20.71 | 15.99 | 23 | 27777 | 16341 | 110545158 |
| Lymphoproliferative disorder | 20.65 | 15.99 | 16 | 27784 | 7202 | 110554297 |
| Diarrhoea | 20.58 | 15.99 | 401 | 27399 | 1139104 | 109422395 |
| Gastric cancer | 20.38 | 15.99 | 19 | 27781 | 10989 | 110550510 |
| Toxic encephalopathy | 20.32 | 15.99 | 22 | 27778 | 15192 | 110546307 |
| Loss of consciousness | 20.02 | 15.99 | 100 | 27700 | 196206 | 110365293 |
| Dermatitis acneiform | 19.90 | 15.99 | 20 | 27780 | 12675 | 110548824 |
| Arthralgia | 19.80 | 15.99 | 115 | 27685 | 779517 | 109781982 |
| Colony stimulating factor therapy | 19.55 | 15.99 | 7 | 27793 | 635 | 110560864 |
| Heart rate increased | 19.40 | 15.99 | 6 | 27794 | 143828 | 110417671 |
| Infusion related reaction | 19.23 | 15.99 | 42 | 27758 | 381120 | 110180379 |
| Oculomucocutaneous syndrome | 19.22 | 15.99 | 6 | 27794 | 356 | 110561143 |
| Osteoarthritis | 19.21 | 15.99 | 11 | 27789 | 182612 | 110378887 |
| Peripheral sensory neuropathy | 18.67 | 15.99 | 22 | 27778 | 16658 | 110544841 |
| Depression | 18.58 | 15.99 | 32 | 27768 | 317303 | 110244196 |
| Blister | 18.39 | 15.99 | 18 | 27782 | 227358 | 110334141 |
| Shock haemorrhagic | 18.28 | 15.99 | 28 | 27772 | 27219 | 110534280 |
| Duodenal ulcer perforation | 18.28 | 15.99 | 11 | 27789 | 177689 | 110383810 |
| Mechanical ileus | 18.05 | 15.99 | 8 | 27792 | 1269 | 110560230 |
| Rash | 18.01 | 15.99 | 298 | 27502 | 820666 | 109740833 |
| Intra-abdominal haemorrhage | 17.86 | 15.99 | 13 | 27787 | 5329 | 110556170 |
| Exposure during pregnancy | 17.73 | 15.99 | 10 | 27790 | 167414 | 110394085 |
| Hepatic atrophy | 17.65 | 15.99 | 6 | 27794 | 467 | 110561032 |
| Diabetes mellitus | 17.58 | 15.99 | 60 | 27740 | 99321 | 110462178 |
| Aortitis | 17.40 | 15.99 | 9 | 27791 | 2006 | 110559493 |
| Immune-mediated cholangitis | 17.37 | 15.99 | 7 | 27793 | 877 | 110560622 |
| Balance disorder | 17.35 | 15.99 | 4 | 27796 | 116556 | 110444943 |
| Malignant ascites | 17.29 | 15.99 | 8 | 27792 | 1402 | 110560097 |
| Compression fracture | 17.12 | 15.99 | 16 | 27784 | 9283 | 110552216 |
| Pleurisy | 17.03 | 15.99 | 18 | 27782 | 12098 | 110549401 |
| Amnesia | 16.97 | 15.99 | 3 | 27797 | 105405 | 110456094 |
| Dehydration | 16.75 | 15.99 | 124 | 27676 | 279387 | 110282112 |
| Pericarditis malignant | 16.59 | 15.99 | 4 | 27796 | 89 | 110561410 |
| Infectious pleural effusion | 16.57 | 15.99 | 12 | 27788 | 4879 | 110556620 |
| Blood creatinine increased | 16.46 | 15.99 | 90 | 27710 | 182799 | 110378700 |
| Cytomegalovirus enterocolitis | 16.36 | 15.99 | 9 | 27791 | 2272 | 110559227 |
| Radius fracture | 16.32 | 15.99 | 11 | 27789 | 3989 | 110557510 |
| Pulmonary artery thrombosis | 16.32 | 15.99 | 8 | 27792 | 1594 | 110559905 |
| Organising pneumonia | 16.30 | 15.99 | 19 | 27781 | 14224 | 110547275 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | M01AE19 | MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Propionic acid derivatives |
| ATC | M02AA31 | MUSCULO-SKELETAL SYSTEM TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN Antiinflammatory preparations, non-steroids for topical use |
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D000894 | Anti-Inflammatory Agents, Non-Steroidal |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D018501 | Antirheumatic Agents |
| MeSH PA | D018689 | Sensory System Agents |
| MeSH PA | D018712 | Analgesics, Non-Narcotic |
| CHEBI has role | CHEBI:35475 | non-steroidal anti-inflammatory drug |
| CHEBI has role | CHEBI:35481 | non-narcotic analgesic |
| CHEBI has role | CHEBI:35493 | antipyretic |
| CHEBI has role | CHEBI:35544 | EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor |
| CHEBI has role | CHEBI:35480 | analgesic |
| CHEBI has role | CHEBI:35842 | antirheumatic drug |
| CHEBI has role | CHEBI:50266 | prodrug |
Related Drugs by ATC class:
M01AE Propionic acid derivatives 21 drugs
M02AA Antiinflammatory preparations, non-steroids for topical use 28 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Rheumatoid arthritis | indication | 69896004 | DOID:7148 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.37 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Prostaglandin G/H synthase 2 | Enzyme | INHIBITOR | IC50 | 5 | CHEMBL | KEGG DRUG | |||
| Prostaglandin G/H synthase 1 | Enzyme | INHIBITOR | IC50 | 5.19 | CHEMBL | KEGG DRUG |
External reference:
| ID | Source |
|---|---|
| D08149 | KEGG_DRUG |
| C0065199 | UMLSCUI |
| CHEBI:31786 | CHEBI |
| CHEMBL19299 | ChEMBL_ID |
| DB09212 | DRUGBANK_ID |
| CHEMBL66552 | ChEMBL_ID |
| C040656 | MESH_SUPPLEMENTAL_RECORD_UI |
| 3965 | PUBCHEM_CID |
| 5410 | INN_ID |
| 80382-23-6 | SECONDARY_CAS_RN |
| 3583H0GZAP | UNII |
| 28908 | RXNORM |
| 008162 | NDDF |
| 18991000122102 | SNOMEDCT_US |
| 484071000221104 | SNOMEDCT_US |
| 3583H0GZAP | INXIGHT DRUGS |
Pharmaceutical products:
None