lornoxicam Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory, isoxicam derivatives 1609 70374-39-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • lornoxicam
  • chlortenoxicam
  • lorcam
  • xefocam
  • Molecular weight: 371.81
  • Formula: C13H10ClN3O4S2
  • CLOGP: 2.34
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 99.60
  • ALOGS: -3.93
  • ROTB: 2

Drug dosage:

DoseUnitRoute
12 mg O
12 mg P
12 mg R

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Angioedema 46.16 32.51 18 656 42058 53306334

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

SourceCodeDescription
ATC M01AC05 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Oxicams
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drugs
CHEBI has role CHEBI:35493 anti-pyretic

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Pain indication 22253000

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 0.98 acidic
pKa2 8.43 acidic
pKa3 5.18 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01866 KEGG_DRUG
C0055477 UMLSCUI
CHEBI:31783 CHEBI
CHEMBL1569487 ChEMBL_ID
DB06725 DRUGBANK_ID
C059451 MESH_SUPPLEMENTAL_RECORD_UI
54690031 PUBCHEM_CID
6233 INN_ID
ER09126G7A UNII
20890 RXNORM
007785 NDDF
391655005 SNOMEDCT_US
412013008 SNOMEDCT_US

Pharmaceutical products:

None