lorcainide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
Class I antiarrhythmics, procainamide and lidocaine derivatives	1607	59729-31-6

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

lorcainide hydrochloride
lorcainide
lorcamide
lorcainide HCl

Molecular weight: 370.92
Formula: C22H27ClN2O
CLOGP: 4.48
LIPINSKI: 0
HAC: 3
HDO: 0
TPSA: 23.55
ALOGS: -4.69
ROTB: 5

Drug dosage:

Dose	Unit	Route
0.20	g	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	2.40 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	1 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	17.98 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution)	6.60 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	16 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.15 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	6.50 hours	Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	C01BC07	CARDIOVASCULAR SYSTEM CARDIAC THERAPY ANTIARRHYTHMICS, CLASS I AND III Antiarrhythmics, class Ic
MeSH PA	D000889	Anti-Arrhythmia Agents
MeSH PA	D002317	Cardiovascular Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.18	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Sodium channel protein type 5 subunit alpha	Ion channel	Q14524	SCN5A_HUMAN					WOMBAT-PK
Sodium channel subunit beta-1	Ion channel	Q07699	SCN1B_HUMAN					WOMBAT-PK
Sodium channel subunit beta-2	Ion channel	O60939	SCN2B_HUMAN					WOMBAT-PK
Sodium channel subunit beta-3	Ion channel	Q9NY72	SCN3B_HUMAN					WOMBAT-PK
Sodium channel subunit beta-4	Ion channel	Q8IWT1	SCN4B_HUMAN					WOMBAT-PK

External reference:

ID	Source
D04778	KEGG_DRUG
58934-46-6	SECONDARY_CAS_RN
C0065183	UMLSCUI
CHEBI:135568	CHEBI
CHEMBL87543	ChEMBL_ID
CHEMBL3085477	ChEMBL_ID
DB13653	DRUGBANK_ID
C015970	MESH_SUPPLEMENTAL_RECORD_UI
42884	PUBCHEM_CID
4143	INN_ID
KGJ2T0N7IQ	UNII
008142	NDDF
008143	NDDF

Pharmaceutical products:

None