lorazepam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diazepam derivatives 1606 846-49-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ativan
  • Wy 4036
  • Wy-4036
  • lorazepam
A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.
  • Molecular weight: 321.16
  • Formula: C15H10Cl2N2O2
  • CLOGP: 2.37
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 61.69
  • ALOGS: -4.26
  • ROTB: 1
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2.50 mg O
2.50 mg P
2.50 mg SL

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.08 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.44 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 93 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.09 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 17 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Sept. 30, 1977 FDA VALEANT INTL

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sopor 2093.81 9.54 1291 290015 20873 63176843
Drug abuse 1256.05 9.54 1605 289701 70913 63126803
Completed suicide 595.15 9.54 1740 289566 143933 63053783
Suicide attempt 565.37 9.54 1008 290298 59910 63137806
Intentional overdose 450.86 9.54 1029 290277 73123 63124593
Somnolence 430.75 9.54 1792 289514 176893 63020823
Neuroleptic malignant syndrome 425.26 9.54 389 290917 11667 63186049
Intentional self-injury 421.60 9.54 554 290752 25133 63172583
Bradyphrenia 387.73 9.54 293 291013 6687 63191029
Agitation 380.83 9.54 845 290461 58912 63138804
Overdose 378.88 9.54 1276 290030 113802 63083914
Coma 344.45 9.54 850 290456 63514 63134202
Drug ineffective 332.57 9.54 3134 288172 1041631 62156085
Contraindicated product administered 302.89 9.54 331 290975 217317 62980399
Delirium 299.01 9.54 694 290612 49847 63147869
Toxicity to various agents 280.66 9.54 2019 289287 245231 62952485
Systemic lupus erythematosus 262.69 9.54 344 290962 208574 62989142
Drug intolerance 252.53 9.54 661 290645 308000 62889716
Pemphigus 250.54 9.54 284 291022 183442 63014274
Catatonia 242.20 9.54 185 291121 4292 63193424
Arthropathy 238.66 9.54 446 290860 234346 62963370
Joint swelling 227.98 9.54 757 290549 326909 62870807
Alopecia 222.55 9.54 798 290508 336738 62860978
Drug withdrawal syndrome 220.80 9.54 425 290881 26769 63170947
Serotonin syndrome 213.25 9.54 432 290874 28250 63169466
Treatment failure 195.33 9.54 386 290920 198657 62999059
Suicidal ideation 194.66 9.54 680 290626 61741 63135975
Pain 193.57 9.54 2323 288983 738305 62459411
Drug interaction 192.38 9.54 1747 289559 227384 62970332
Anxiety 191.03 9.54 1675 289631 215866 62981850
Glossodynia 181.51 9.54 340 290966 178536 63019180
Therapeutic product effect decreased 179.94 9.54 386 290920 192801 63004915
Hand deformity 178.28 9.54 285 291021 159172 63038544
Disorientation 176.15 9.54 487 290819 38965 63158751
Poisoning 174.92 9.54 262 291044 13438 63184278
Hypersensitivity 170.43 9.54 727 290579 291958 62905758
Tachycardia 167.85 9.54 1021 290285 117135 63080581
Arthralgia 164.29 9.54 1747 289559 567963 62629753
Restlessness 163.93 9.54 395 290911 29058 63168658
Swelling 163.42 9.54 679 290627 274699 62923017
Mydriasis 163.26 9.54 236 291070 11720 63185996
Rheumatoid arthritis 161.96 9.54 608 290698 253211 62944505
Psychotic disorder 161.94 9.54 362 290944 25350 63172366
Confusional state 159.82 9.54 1723 289583 234657 62963059
Rash 156.05 9.54 1734 289572 559137 62638579
Depressed level of consciousness 154.35 9.54 629 290677 61449 63136267
Bradykinesia 153.64 9.54 152 291154 5036 63192680
Pneumonia aspiration 151.86 9.54 424 290882 34116 63163600
Respiratory depression 151.00 9.54 245 291061 13470 63184246
Drug dependence 150.07 9.54 341 290965 24142 63173574
Abdominal discomfort 147.89 9.54 865 290441 320020 62877696
Synovitis 144.65 9.54 411 290895 186507 63011209
Mania 144.51 9.54 227 291079 12140 63185576
Akathisia 131.45 9.54 185 291121 8961 63188755
Extrapyramidal disorder 123.38 9.54 220 291086 13064 63184652
Maternal exposure during pregnancy 119.36 9.54 561 290745 219501 62978215
Speech disorder 119.28 9.54 434 290872 40195 63157521
Infusion related reaction 111.89 9.54 664 290642 244857 62952859
Anti-cyclic citrullinated peptide antibody positive 110.82 9.54 229 291077 115983 63081733
Febrile neutropenia 110.12 9.54 924 290382 117525 63080191
Muscle rigidity 110.09 9.54 193 291113 11307 63186409
Tremor 108.16 9.54 1003 290303 131236 63066480
Delusion 103.97 9.54 193 291113 11824 63185892
Mental status changes 102.22 9.54 406 290900 39193 63158523
Psychomotor hyperactivity 99.55 9.54 177 291129 10486 63187230
Wound 98.35 9.54 400 290906 162863 63034853
Abnormal behaviour 97.13 9.54 266 291040 21160 63176556
Hallucination, auditory 95.13 9.54 193 291113 12631 63185085
Slow speech 93.48 9.54 68 291238 1461 63196255
Hypothermia 92.10 9.54 197 291109 13384 63184332
Respiratory arrest 91.87 9.54 344 290962 32301 63165415
Aggression 91.30 9.54 276 291030 23222 63174494
Tardive dyskinesia 91.06 9.54 150 291156 8352 63189364
Psychomotor retardation 90.61 9.54 100 291206 3770 63193946
Product use issue 89.89 9.54 617 290689 219903 62977813
Hepatic enzyme increased 89.63 9.54 552 290754 201776 62995940
Seizure 89.14 9.54 966 290340 131668 63066048
Device expulsion 88.82 9.54 25 291281 34897 63162819
COVID-19 88.70 9.54 247 291059 112856 63084860
Off label use 88.24 9.54 2389 288917 672073 62525643
Dysarthria 87.97 9.54 409 290897 42302 63155414
Withdrawal syndrome 84.49 9.54 242 291064 19755 63177961
Gastric pH decreased 83.16 9.54 49 291257 725 63196991
Derealisation 81.39 9.54 57 291249 1151 63196565
Schizophrenia 81.34 9.54 156 291150 9796 63187920
Mutism 80.88 9.54 64 291242 1566 63196150
Mobility decreased 80.62 9.54 285 291021 120874 63076842
Electrocardiogram QT prolonged 80.45 9.54 508 290798 59022 63138694
Drug hypersensitivity 79.00 9.54 979 290327 309708 62888008
Depression 77.99 9.54 1301 290005 195191 63002525
Status epilepticus 76.03 9.54 196 291110 15037 63182679
Bezoar 75.90 9.54 60 291246 1466 63196250
Unresponsive to stimuli 75.76 9.54 332 290974 33484 63164232
Pericarditis 75.74 9.54 328 290978 131251 63066465
Drooling 75.51 9.54 91 291215 3777 63193939
Therapeutic product effect incomplete 74.29 9.54 308 290998 124748 63072968
Cogwheel rigidity 74.26 9.54 66 291240 1904 63195812
Cardiac arrest 74.17 9.54 699 290607 91846 63105870
Sedation 72.96 9.54 362 290944 38447 63159269
Discomfort 72.88 9.54 459 290847 166915 63030801
Substance abuse 71.72 9.54 99 291207 4708 63193008
Sinus tachycardia 71.02 9.54 259 291047 24009 63173707
Pneumonia viral 69.50 9.54 128 291178 7794 63189922
Hallucination 69.30 9.54 460 290846 54357 63143359
Soft tissue disorder 68.89 9.54 93 291213 4329 63193387
Hyponatraemia 68.82 9.54 801 290505 111099 63086617
Injection site pain 68.51 9.54 334 290972 129466 63068250
Dehydration 68.12 9.54 1146 290160 172208 63025508
Incontinence 67.96 9.54 159 291147 11473 63186243
Salivary hypersecretion 67.43 9.54 124 291182 7542 63190174
Rheumatoid factor positive 65.67 9.54 185 291121 84221 63113495
Injection site erythema 64.94 9.54 182 291124 82992 63114724
Dissociation 64.19 9.54 73 291233 2846 63194870
Paranoia 63.23 9.54 155 291151 11524 63186192
Electrocardiogram QRS complex prolonged 62.57 9.54 104 291202 5834 63191882
Psoriasis 62.32 9.54 198 291108 86759 63110957
Dystonia 62.08 9.54 171 291135 13648 63184068
Mental disorder 60.77 9.54 258 291048 25661 63172055
Sinusitis 60.70 9.54 706 290600 225947 62971769
Infection 59.39 9.54 719 290587 228454 62969262
Feeling of despair 59.24 9.54 63 291243 2276 63195440
Brain injury 58.30 9.54 111 291195 6932 63190784
Hypoxia 56.36 9.54 468 290838 59324 63138392
Hypokinesia 56.33 9.54 166 291140 13770 63183946
Pruritus 56.17 9.54 1247 290059 360206 62837510
Loss of consciousness 55.97 9.54 806 290500 117315 63080401
Depersonalisation/derealisation disorder 55.81 9.54 48 291258 1324 63196392
Persecutory delusion 55.05 9.54 66 291240 2724 63194992
Computerised tomogram thorax abnormal 54.72 9.54 53 291253 1710 63196006
Narcotic bowel syndrome 54.49 9.54 22 291284 131 63197585
Stupor 53.49 9.54 81 291225 4194 63193522
Peripheral swelling 53.44 9.54 878 290428 265064 62932652
Product dose omission issue 53.42 9.54 755 290551 233558 62964158
Interstitial lung disease 53.27 9.54 129 291177 61779 63135937
Myelosuppression 53.23 9.54 21 291285 23682 63174034
Hallucinations, mixed 52.80 9.54 86 291220 4743 63192973
Hallucination, visual 52.35 9.54 201 291105 19097 63178619
Blister 51.00 9.54 367 290939 129447 63068269
Cardio-respiratory arrest 50.61 9.54 458 290848 59501 63138215
Computerised tomogram thorax 49.75 9.54 29 291277 420 63197296
H1N1 influenza 49.74 9.54 50 291256 1689 63196027
Alcohol interaction 49.21 9.54 58 291248 2351 63195365
Nasopharyngitis 48.93 9.54 846 290460 253411 62944305
Dyskinesia 48.90 9.54 282 291024 31720 63165996
Coma scale abnormal 48.70 9.54 86 291220 5067 63192649
Multiple-drug resistance 48.49 9.54 86 291220 5084 63192632
Therapeutic response decreased 48.49 9.54 134 291172 61391 63136325
Respiratory failure 48.24 9.54 695 290611 101163 63096553
Diabetes insipidus 46.80 9.54 59 291247 2566 63195150
Erythema 45.67 9.54 551 290755 175200 63022516
Injection site reaction 44.26 9.54 130 291176 58394 63139322
Skin necrosis 43.81 9.54 6 291300 13944 63183772
Fall 43.76 9.54 2210 289096 390124 62807592
C-reactive protein increased 43.68 9.54 255 291051 94452 63103264
Condition aggravated 43.66 9.54 1460 289846 400757 62796959
Headache 42.89 9.54 2423 288883 630818 62566898
Lower respiratory tract infection 42.82 9.54 394 290912 131913 63065803
Miosis 42.40 9.54 100 291206 7253 63190463
Injection site pruritus 41.24 9.54 91 291215 45025 63152691
Panic attack 41.05 9.54 207 291099 22124 63175592
Red blood cell sedimentation rate increased 40.79 9.54 88 291218 43894 63153822
Hypertonia 40.77 9.54 75 291231 4562 63193154
Mood swings 40.75 9.54 179 291127 18069 63179647
Psoriatic arthropathy 40.32 9.54 250 291056 91270 63106446
Cytomegalovirus infection 40.25 9.54 23 291283 20929 63176787
Compartment syndrome 40.18 9.54 51 291255 2233 63195483
Alcohol abuse 39.48 9.54 49 291257 2097 63195619
Hypotension 39.44 9.54 1577 289729 271027 62926689
Osmolar gap increased 39.39 9.54 16 291290 97 63197619
Encephalitis autoimmune 39.37 9.54 41 291265 1445 63196271
Disorganised speech 39.21 9.54 38 291268 1227 63196489
Hyperreflexia 39.00 9.54 85 291221 5849 63191867
Pain in extremity 38.89 9.54 1191 290115 330295 62867421
Crying 38.52 9.54 210 291096 23133 63174583
Somatic symptom disorder 38.51 9.54 54 291252 2606 63195110
Apnoea 37.77 9.54 101 291205 7921 63189795
Insomnia 37.38 9.54 1271 290035 213981 62983735
Decorticate posture 37.15 9.54 21 291285 286 63197430
Myocardial depression 36.83 9.54 25 291281 479 63197237
Emotional disorder 36.82 9.54 140 291166 13239 63184477
Newborn persistent pulmonary hypertension 36.59 9.54 19 291287 216 63197500
Tachypnoea 36.59 9.54 167 291139 17135 63180581
Small intestinal obstruction 36.58 9.54 174 291132 18163 63179553
Myoclonus 36.46 9.54 157 291149 15711 63182005
Mental impairment 36.44 9.54 145 291161 14006 63183710
Urinary retention 35.74 9.54 250 291056 30051 63167665
Poisoning deliberate 35.63 9.54 123 291183 11095 63186621
Deep vein thrombosis postoperative 35.54 9.54 124 291182 11245 63186471
Change of bowel habit 35.51 9.54 47 291259 2146 63195570
Nicotine dependence 35.25 9.54 28 291278 689 63197027
Drug eruption 35.24 9.54 48 291258 28646 63169070
Propofol infusion syndrome 35.21 9.54 32 291274 951 63196765
Respiratory acidosis 35.17 9.54 88 291218 6627 63191089
Injection site swelling 35.01 9.54 107 291199 47465 63150251
Abortion spontaneous 34.84 9.54 106 291200 47089 63150627
Oral pain 34.52 9.54 236 291070 28158 63169558
Loss of personal independence in daily activities 34.46 9.54 283 291023 97007 63100709
Victim of sexual abuse 34.25 9.54 27 291279 657 63197059
Psychiatric decompensation 34.19 9.54 37 291269 1364 63196352
Blood prolactin increased 33.80 9.54 59 291247 3444 63194272
Red blood cell sedimentation rate abnormal 33.54 9.54 25 291281 19757 63177959
Atelectasis 33.27 9.54 190 291116 21293 63176423
Knee arthroplasty 33.12 9.54 132 291174 54074 63143642
Dysphagia 33.09 9.54 581 290725 88004 63109712
Patient uncooperative 32.61 9.54 17 291289 195 63197521
Mouth ulceration 32.27 9.54 64 291242 32920 63164796
PO2 increased 32.24 9.54 29 291277 850 63196866
Basal cell carcinoma 32.23 9.54 49 291257 27942 63169774
Parosmia 32.16 9.54 81 291225 6125 63191591
Anaphylactic shock 31.66 9.54 37 291269 23596 63174120
Encephalopathy 31.07 9.54 292 291014 38328 63159388
Lip dry 31.01 9.54 147 291159 15323 63182393
Blood pH decreased 30.94 9.54 48 291258 2539 63195177
Pulseless electrical activity 30.79 9.54 90 291216 7431 63190285
Asthenia 30.39 9.54 2096 289210 381508 62816208
Disturbance in attention 30.35 9.54 288 291018 37901 63159815
Exposure during pregnancy 30.07 9.54 517 290789 155030 63042686
Nightmare 29.89 9.54 170 291136 19024 63178692
Feeling of body temperature change 29.77 9.54 68 291238 4829 63192887
CSF oligoclonal band present 29.61 9.54 20 291286 380 63197336
Renal ischaemia 29.59 9.54 24 291282 609 63197107
Aspiration 29.41 9.54 113 291193 10738 63186978
Cataract 29.40 9.54 148 291158 56905 63140811
Facet joint syndrome 29.37 9.54 122 291184 12016 63185700
Electroencephalogram abnormal 29.32 9.54 57 291249 3615 63194101
Wrong patient received product 29.31 9.54 43 291263 2164 63195552
Myocardial reperfusion injury 29.29 9.54 13 291293 101 63197615
Joint injury 29.26 9.54 57 291249 29515 63168201
Blood creatine phosphokinase increased 29.11 9.54 239 291067 30191 63167525
Musculoskeletal stiffness 28.88 9.54 636 290670 183982 63013734
Lethargy 28.87 9.54 388 290918 55619 63142097
Breast cancer female 28.86 9.54 13 291293 13546 63184170
Hypotonia neonatal 28.83 9.54 32 291274 1214 63196502
Generalised tonic-clonic seizure 28.35 9.54 229 291077 28787 63168929
Intentional product misuse 28.17 9.54 414 290892 60503 63137213
Skin ulcer 28.12 9.54 102 291204 42943 63154773
Feeling jittery 28.07 9.54 129 291177 13274 63184442
Bradycardia 27.96 9.54 482 290824 72745 63124971
Constipation 27.96 9.54 1281 290025 223662 62974054
Pancreatic fibrosis 27.86 9.54 12 291294 86 63197630
Aphasia 27.80 9.54 252 291054 32748 63164968
Hepatic function abnormal 27.72 9.54 83 291223 37059 63160657
Parkinsonism 27.72 9.54 108 291198 10331 63187385
Restless legs syndrome 27.47 9.54 162 291144 18369 63179347
Panniculitis 27.41 9.54 9 291297 11376 63186340
PCO2 increased 27.27 9.54 31 291275 1208 63196508
Hypophagia 27.00 9.54 240 291066 31019 63166697
Neonatal seizure 26.99 9.54 21 291285 501 63197215
Respiratory distress 26.96 9.54 256 291050 33695 63164021
Macular degeneration 26.80 9.54 44 291262 24332 63173384
Peripheral venous disease 26.73 9.54 141 291165 15336 63182380
Tenosynovitis 26.70 9.54 15 291291 13780 63183936
Bronchiectasis 26.60 9.54 21 291285 16121 63181595
Accidental exposure to product by child 26.51 9.54 30 291276 1163 63196553
Obsessive-compulsive disorder 26.51 9.54 58 291248 4002 63193714
Major depression 26.42 9.54 89 291217 7929 63189787
Cerebral microhaemorrhage 26.39 9.54 13 291293 131 63197585
Mean cell haemoglobin increased 26.38 9.54 48 291258 2895 63194821
Schizophreniform disorder 26.38 9.54 11 291295 72 63197644
Neonatal asphyxia 26.25 9.54 17 291289 300 63197416
Brain death 26.10 9.54 52 291254 3358 63194358
Phagophobia 26.04 9.54 10 291296 51 63197665
Morbid thoughts 25.76 9.54 22 291284 601 63197115
Premature delivery 25.34 9.54 64 291242 30217 63167499
Granulocytopenia 25.29 9.54 70 291236 5602 63192114
Plasma cell myeloma 25.25 9.54 264 291042 35641 63162075
Mitochondrial encephalomyopathy 24.90 9.54 8 291298 21 63197695
Hyperammonaemic encephalopathy 24.80 9.54 42 291264 2392 63195324
Immunodeficiency 24.75 9.54 34 291272 20220 63177496
Emotional distress 24.65 9.54 243 291063 32306 63165410
Antipsychotic drug level increased 24.65 9.54 51 291255 3384 63194332
Bone erosion 24.54 9.54 27 291279 17690 63180026
Pneumocystis jirovecii pneumonia 24.29 9.54 25 291281 16889 63180827
Coma scale 24.26 9.54 9 291297 41 63197675
Macrocytosis 24.17 9.54 42 291264 2443 63195273
Femur fracture 24.06 9.54 104 291202 41652 63156064
Depressed mood 23.93 9.54 286 291020 39905 63157811
Blood bicarbonate decreased 23.91 9.54 46 291260 2895 63194821
Hyperhidrosis 23.85 9.54 656 290650 107180 63090536
Dry mouth 23.71 9.54 495 290811 77368 63120348
Ill-defined disorder 23.70 9.54 250 291056 81505 63116211
Acute psychosis 23.68 9.54 42 291264 2483 63195233
Solar urticaria 23.54 9.54 10 291296 69 63197647
Homicide 23.26 9.54 17 291289 368 63197348
Neurosensory hypoacusis 23.25 9.54 14 291292 216 63197500
Areflexia 23.21 9.54 47 291259 3071 63194645
Menstrual disorder 23.13 9.54 65 291241 5248 63192468
Homicidal ideation 23.07 9.54 34 291272 1718 63195998
Neutropenic sepsis 22.82 9.54 25 291281 16413 63181303
Urinary incontinence 22.80 9.54 236 291070 31778 63165938
Malaise 22.65 9.54 1623 289683 414331 62783385
Upper respiratory tract infection 22.54 9.54 254 291052 81793 63115923
Bradypnoea 22.37 9.54 50 291256 3500 63194216
Suicidal behaviour 22.35 9.54 42 291264 2597 63195119
Hip arthroplasty 22.11 9.54 128 291178 47518 63150198
Sputum purulent 21.92 9.54 26 291280 1061 63196655
Blood sodium decreased 21.88 9.54 188 291118 24064 63173652
Mitochondrial DNA mutation 21.87 9.54 17 291289 405 63197311
Affective disorder 21.85 9.54 70 291236 6076 63191640
Muscle disorder 21.84 9.54 61 291245 4908 63192808
Sacroiliitis 21.80 9.54 47 291259 3210 63194506
Screaming 21.75 9.54 47 291259 3215 63194501
Impaired healing 21.74 9.54 335 290971 102207 63095509
Bone density decreased 21.67 9.54 21 291285 14591 63183125
Respiratory alkalosis 21.66 9.54 42 291264 2659 63195057
Toxic epidermal necrolysis 21.62 9.54 53 291253 25281 63172435
Communication disorder 21.44 9.54 40 291266 2460 63195256
Impaired quality of life 21.40 9.54 19 291287 13764 63183952
Respiratory rate decreased 21.40 9.54 49 291257 3486 63194230
Alcohol use 21.35 9.54 36 291270 2043 63195673
Ataxia 21.35 9.54 131 291175 15064 63182652
Skin reaction 21.27 9.54 22 291284 14827 63182889
Behaviour disorder 21.23 9.54 46 291260 3153 63194563
Apallic syndrome 21.12 9.54 21 291285 700 63197016
Autoimmune disorder 21.02 9.54 143 291163 17034 63180682
Foot deformity 20.96 9.54 62 291244 27791 63169925
Skin maceration 20.96 9.54 8 291298 40 63197676
Vomiting 20.95 9.54 2901 288405 556716 62641000
Hypochloraemia 20.92 9.54 35 291271 1974 63195742
Altered state of consciousness 20.92 9.54 192 291114 25038 63172678
Rectal polyp 20.75 9.54 27 291279 1212 63196504
Waxy flexibility 20.74 9.54 11 291295 131 63197585
Echolalia 20.70 9.54 13 291293 217 63197499
Osteoporosis 20.66 9.54 166 291140 57172 63140544
Coeliac disease 20.65 9.54 17 291289 12780 63184936
Device difficult to use 20.64 9.54 17 291289 12779 63184937
Staring 20.56 9.54 31 291275 1599 63196117
Paralysis 20.52 9.54 95 291211 9805 63187911
Therapy interrupted 20.48 9.54 78 291228 32377 63165339
Ulcer 20.46 9.54 57 291249 26050 63171666
Failure to thrive 20.37 9.54 76 291230 7122 63190594
Fear 20.34 9.54 133 291173 15633 63182083
Drop attacks 20.23 9.54 20 291286 662 63197054
Hypoxic-ischaemic encephalopathy 20.21 9.54 54 291252 4233 63193483
Bipolar disorder 20.04 9.54 81 291225 7879 63189837
Mood altered 20.02 9.54 126 291180 14617 63183099
Accidental death 20.01 9.54 34 291272 1942 63195774
Haematotoxicity 19.94 9.54 9 291297 9367 63188349
Haemophagocytic lymphohistiocytosis 19.94 9.54 12 291294 10615 63187101
Myocardial fibrosis 19.92 9.54 21 291285 751 63196965
Injection site bruising 19.77 9.54 112 291194 41798 63155918
Hepatic cytolysis 19.71 9.54 25 291281 15382 63182334
Protein C increased 19.62 9.54 10 291296 109 63197607
Rapid eye movements sleep abnormal 19.51 9.54 11 291295 149 63197567
Fibromyalgia 19.44 9.54 495 290811 79925 63117791
Ventricular hypokinesia 19.42 9.54 56 291250 4588 63193128
Alcohol poisoning 19.41 9.54 33 291273 1886 63195830
Leukocytosis 19.34 9.54 193 291113 25742 63171974
Device issue 19.33 9.54 51 291255 23730 63173986
Torsade de pointes 19.33 9.54 116 291190 13235 63184481
Oxygen saturation abnormal 19.28 9.54 47 291259 3482 63194234
Hyperprolactinaemia 19.27 9.54 50 291256 3850 63193866
Disease recurrence 19.26 9.54 65 291241 27965 63169751
Psychomotor skills impaired 19.21 9.54 37 291269 2331 63195385
Monocyte count decreased 19.15 9.54 35 291271 2118 63195598
Withdrawal catatonia 19.15 9.54 9 291297 81 63197635
Accidental overdose 19.13 9.54 177 291129 23132 63174584
Vitamin B1 decreased 19.12 9.54 12 291294 200 63197516
Refusal of treatment by patient 18.99 9.54 62 291244 5435 63192281
Renal impairment 18.95 9.54 288 291018 88067 63109649
Urine abnormality 18.95 9.54 73 291233 6946 63190770
Pallor 18.85 9.54 219 291087 30349 63167367
Drug use disorder 18.85 9.54 58 291248 4926 63192790
Drug tolerance decreased 18.79 9.54 32 291274 17441 63180275
Sleep disorder due to a general medical condition 18.68 9.54 17 291289 12171 63185545
Decreased appetite 18.68 9.54 1365 289941 249687 62948029
Oropharyngeal swelling 18.52 9.54 22 291284 899 63196817
Patent ductus arteriosus 18.51 9.54 52 291254 4198 63193518
Rhesus antigen positive 18.51 9.54 10 291296 124 63197592
Inappropriate antidiuretic hormone secretion 18.49 9.54 128 291178 15334 63182382
Pleocytosis 18.36 9.54 21 291285 824 63196892
Creatinine renal clearance decreased 18.34 9.54 29 291277 16279 63181437
Persistent left superior vena cava 18.34 9.54 7 291299 35 63197681
Frustration tolerance decreased 18.31 9.54 72 291234 6916 63190800
Polyarthritis 18.29 9.54 12 291294 10134 63187582
No adverse event 18.28 9.54 113 291193 41292 63156424
Arthritis 18.22 9.54 399 290907 115522 63082194
Ear infection 18.09 9.54 102 291204 38111 63159605
Alcoholism 18.04 9.54 31 291275 1787 63195929
Device malfunction 18.03 9.54 34 291272 17823 63179893
Rhabdomyolysis 17.76 9.54 292 291014 43659 63154057
Inflammation 17.71 9.54 268 291038 82005 63115711
Logorrhoea 17.70 9.54 37 291269 2473 63195243
Joint effusion 17.66 9.54 32 291274 17028 63180688
Dementia 17.65 9.54 147 291159 18647 63179069
Blood gases abnormal 17.64 9.54 20 291286 777 63196939
Tremor neonatal 17.58 9.54 10 291296 138 63197578
Neutrophil count increased 17.56 9.54 133 291173 16394 63181322
Generalised anxiety disorder 17.55 9.54 33 291273 2041 63195675
Therapy cessation 17.46 9.54 76 291230 30381 63167335
Haemoglobin urine 17.45 9.54 10 291296 140 63197576
Galactorrhoea 17.28 9.54 50 291256 4105 63193611
Rash pruritic 17.27 9.54 183 291123 59616 63138100
Laryngeal injury 17.20 9.54 5 291301 8 63197708
Finger deformity 17.17 9.54 7 291299 7738 63189978
Injection site rash 17.14 9.54 38 291268 18771 63178945
Medication error 17.11 9.54 336 290970 51948 63145768
Wrong drug 17.09 9.54 11 291295 192 63197524
Hypotonia 17.02 9.54 86 291220 9199 63188517
Metabolic encephalopathy 17.00 9.54 62 291244 5747 63191969
Metabolic alkalosis 16.97 9.54 41 291265 3020 63194696
Blood lactic acid decreased 16.97 9.54 10 291296 148 63197568
Device use error 16.91 9.54 3 291303 5758 63191958
Proctalgia 16.87 9.54 64 291242 6046 63191670
Joint destruction 16.81 9.54 4 291302 6248 63191468
Hyperchloraemia 16.64 9.54 19 291287 744 63196972
On and off phenomenon 16.54 9.54 30 291276 1805 63195911
Hypokalaemia 16.52 9.54 607 290699 103197 63094519
Cough 16.44 9.54 1139 290167 291604 62906112
Gallbladder disorder 16.44 9.54 145 291161 18697 63179019
Tracheal atresia 16.41 9.54 6 291300 26 63197690
Acute generalised exanthematous pustulosis 16.40 9.54 16 291290 11083 63186633
Unintentional medical device removal 16.27 9.54 4 291302 6111 63191605
pH urine increased 16.22 9.54 14 291292 388 63197328
Prescribed overdose 16.14 9.54 233 291073 33920 63163796
Anxiety disorder 16.14 9.54 48 291258 4002 63193714
Nervousness 16.12 9.54 215 291091 30764 63166952
Dysphemia 16.10 9.54 37 291269 2638 63195078
Irritability 16.10 9.54 219 291087 31475 63166241
Pleurothotonus 16.09 9.54 25 291281 1324 63196392
Muscle spasticity 16.05 9.54 49 291257 21745 63175971
Therapeutic product ineffective 16.01 9.54 29 291277 1743 63195973
Tendonitis 15.99 9.54 42 291264 19573 63178143
Neonatal behavioural syndrome 15.93 9.54 7 291299 53 63197663
Sleep disorder due to general medical condition, insomnia type 15.82 9.54 158 291148 52059 63145657
Atonic seizures 15.81 9.54 17 291289 622 63197094
Postural tremor 15.76 9.54 13 291293 338 63197378
Dopamine transporter scintigraphy abnormal 15.71 9.54 8 291298 87 63197629
Cardiac malposition 15.71 9.54 7 291299 55 63197661
Breast cancer stage I 15.64 9.54 6 291300 6883 63190833
Neonatal respiratory failure 15.61 9.54 12 291294 281 63197435
Bronchitis 15.58 9.54 445 290861 124490 63073226
Hypervigilance 15.54 9.54 13 291293 345 63197371
Cannabinoid hyperemesis syndrome 15.49 9.54 7 291299 57 63197659
Angioedema 15.44 9.54 143 291163 47822 63149894
Anger 15.42 9.54 104 291202 12352 63185364
Anomalous pulmonary venous connection 15.39 9.54 7 291299 58 63197658
Platelet production decreased 15.33 9.54 4 291302 3 63197713
Thymus disorder 15.33 9.54 12 291294 289 63197427
Self-medication 15.31 9.54 37 291269 2726 63194990
Cholangitis infective 15.29 9.54 13 291293 353 63197363
Gastrointestinal sounds abnormal 15.19 9.54 47 291259 4004 63193712
Apathy 15.11 9.54 80 291226 8714 63189002
Suspected suicide attempt 15.05 9.54 9 291297 137 63197579
Death 15.00 9.54 1949 289357 372432 62825284
Respiratory tract infection 14.99 9.54 120 291186 41363 63156353
Morose 14.96 9.54 6 291300 35 63197681
Squamous cell carcinoma of the oral cavity 14.95 9.54 12 291294 300 63197416
Psychotic behaviour 14.91 9.54 16 291290 584 63197132
Autonomic nervous system imbalance 14.83 9.54 37 291269 2781 63194935
Obesity 14.82 9.54 206 291100 29746 63167970
Tooth hypoplasia 14.80 9.54 7 291299 64 63197652
Fluid retention 14.78 9.54 189 291117 59497 63138219
Central nervous system necrosis 14.77 9.54 9 291297 142 63197574
Loss of libido 14.72 9.54 24 291282 1325 63196391
Gait disturbance 14.66 9.54 1002 290304 182176 63015540
Amnesia 14.59 9.54 346 290960 55239 63142477
Impaired work ability 14.57 9.54 37 291269 17438 63180278
Diaphragmatic rupture 14.55 9.54 11 291295 251 63197465
Transient aphasia 14.55 9.54 6 291300 38 63197678
Lymphocyte count decreased 14.53 9.54 207 291099 30050 63167666
Enthesopathy 14.46 9.54 11 291295 8603 63189113
Uveitis 14.43 9.54 22 291284 12531 63185185
Injury 14.38 9.54 439 290867 72808 63124908
Pulmonary embolism 14.37 9.54 664 290642 116020 63081696
Duodenal ulcer perforation 14.33 9.54 298 291008 86911 63110805
Drug clearance decreased 14.33 9.54 25 291281 1459 63196257
Oppositional defiant disorder 14.30 9.54 6 291300 40 63197676
Glaucoma 14.28 9.54 42 291264 18863 63178853
Secondary immunodeficiency 14.27 9.54 24 291282 1359 63196357
Bulimia nervosa 14.24 9.54 14 291292 460 63197256
Head injury 14.20 9.54 190 291116 27206 63170510
Arrhythmia 14.18 9.54 250 291056 37890 63159826
Ductus arteriosus premature closure 14.17 9.54 12 291294 324 63197392
Febrile bone marrow aplasia 14.13 9.54 8 291298 7317 63190399
Intentional product use issue 14.12 9.54 463 290843 127429 63070287
Skin exfoliation 14.09 9.54 128 291178 42974 63154742
Inappropriate schedule of product administration 14.08 9.54 366 290940 103599 63094117
Visceral congestion 14.04 9.54 12 291294 328 63197388
Cardiac failure 13.95 9.54 307 290999 88835 63108881
Extensor plantar response 13.86 9.54 23 291283 1288 63196428
Thinking abnormal 13.86 9.54 90 291216 10553 63187163
Electrocardiogram T wave abnormal 13.81 9.54 33 291273 2414 63195302
Foot operation 13.80 9.54 8 291298 7223 63190493
Suspected suicide 13.60 9.54 63 291243 6505 63191211
Pulmonary toxicity 13.55 9.54 14 291292 9441 63188275
Echopraxia 13.44 9.54 5 291301 23 63197693
Mucosal dryness 13.38 9.54 35 291271 2709 63195007
Rheumatic fever 13.25 9.54 130 291176 42981 63154735
Sleep disorder 13.23 9.54 478 290828 81088 63116628
Pruritus allergic 13.18 9.54 25 291281 1557 63196159
Antidepressant drug level below therapeutic 13.17 9.54 3 291303 0 63197716
Maximal voluntary ventilation abnormal 13.10 9.54 5 291301 25 63197691
Pupillary reflex impaired 13.09 9.54 29 291277 2018 63195698
Abdominal pain 13.08 9.54 1538 289768 291918 62905798
Device dislocation 13.06 9.54 67 291239 25638 63172078
Blood albumin increased 13.04 9.54 19 291287 950 63196766
Drug abuser 12.96 9.54 36 291270 2887 63194829
Hypernatraemia 12.92 9.54 69 291237 7540 63190176
Surgery 12.92 9.54 104 291202 35808 63161908
Congenital pneumonia 12.88 9.54 4 291302 9 63197707
Drug screen false positive 12.88 9.54 18 291288 866 63196850
Benzodiazepine drug level increased 12.80 9.54 9 291297 183 63197533
Induced abortion failed 12.73 9.54 10 291296 242 63197474
Anaphylactic reaction 12.67 9.54 220 291086 65880 63131836
Neutrophil Pelger-Huet anomaly present 12.67 9.54 7 291299 91 63197625
Vasculitis 12.67 9.54 42 291264 18167 63179549
Influenza 12.62 9.54 391 290915 108331 63089385
Labelled drug-drug interaction issue 12.57 9.54 20 291286 1081 63196635
Joint stiffness 12.55 9.54 127 291179 41742 63155974
Cerebellar haematoma 12.50 9.54 12 291294 383 63197333
Delusion of grandeur 12.49 9.54 10 291296 249 63197467
Product complaint 12.46 9.54 101 291205 12708 63185008
Acute respiratory failure 12.45 9.54 225 291081 34260 63163456
Inflammatory marker increased 12.45 9.54 8 291298 6831 63190885
Inappropriate affect 12.42 9.54 18 291288 896 63196820
Normal newborn 12.36 9.54 12 291294 8329 63189387
Live birth 12.35 9.54 68 291238 25562 63172154
Vulvar basal cell carcinoma 12.35 9.54 5 291301 30 63197686
Leukopenia neonatal 12.35 9.54 5 291301 30 63197686
Melaena 12.33 9.54 85 291221 30280 63167436
Hyperthyroidism 12.29 9.54 31 291275 14642 63183074
Parachute mitral valve 12.28 9.54 7 291299 97 63197619
Urine ketone body present 12.28 9.54 32 291274 2471 63195245
Diverticulitis 12.27 9.54 119 291187 39438 63158278
Rabbit syndrome 12.27 9.54 11 291295 321 63197395
Impaired driving ability 12.25 9.54 47 291259 4464 63193252
Arterial spasm 12.22 9.54 6 291300 60 63197656
Musculoskeletal disorder 12.15 9.54 51 291255 20593 63177123
Erysipelas 12.15 9.54 11 291295 7894 63189822
Incoherent 12.13 9.54 47 291259 4483 63193233
Autologous bone marrow transplantation therapy 12.07 9.54 4 291302 12 63197704
Depressive delusion 12.07 9.54 4 291302 12 63197704
Soft tissue swelling 12.07 9.54 21 291285 1223 63196493
Osteonecrosis of jaw 12.05 9.54 103 291203 35020 63162696
Sluggishness 12.00 9.54 52 291254 5217 63192499
Adverse event 11.96 9.54 228 291078 67331 63130385
Tachyphylaxis 11.93 9.54 10 291296 266 63197450
Cognitive disorder 11.90 9.54 338 290968 55477 63142239
Therapy non-responder 11.87 9.54 443 290863 75458 63122258
Pleural adhesion 11.85 9.54 7 291299 104 63197612
Cardiac failure congestive 11.84 9.54 328 290978 92105 63105611
Hypoprolactinaemia 11.83 9.54 4 291302 13 63197703
Tachyphrenia 11.80 9.54 22 291284 1352 63196364
Hepatitis 11.80 9.54 121 291185 39667 63158049
Rhinalgia 11.78 9.54 24 291282 1575 63196141
Nephrogenic diabetes insipidus 11.76 9.54 18 291288 941 63196775
Water intoxication 11.71 9.54 12 291294 415 63197301
Acute respiratory distress syndrome 11.70 9.54 162 291144 23372 63174344
Cyanosis 11.66 9.54 124 291182 16811 63180905
Device breakage 11.63 9.54 22 291284 11520 63186196
Vasoconstriction 11.60 9.54 14 291292 582 63197134
Scleritis 11.58 9.54 3 291303 4425 63193291
Differential white blood cell count abnormal 11.45 9.54 16 291290 770 63196946
Neoplasm malignant 11.44 9.54 85 291221 29776 63167940
Kluver-Bucy syndrome 11.39 9.54 4 291302 15 63197701
Hypersexuality 11.39 9.54 13 291293 509 63197207
Stereotypy 11.36 9.54 12 291294 430 63197286
Partial seizures 11.34 9.54 55 291251 5787 63191929
Drug screen negative 11.32 9.54 10 291296 286 63197430
Left ventricle outflow tract obstruction 11.32 9.54 10 291296 286 63197430
Injection site warmth 11.31 9.54 34 291272 15161 63182555
Biliary tract infection 11.30 9.54 15 291291 687 63197029
Anion gap increased 11.29 9.54 26 291280 1856 63195860
Brain oedema 11.25 9.54 107 291199 14088 63183628
Polydipsia 11.25 9.54 39 291267 3525 63194191
Amegakaryocytic thrombocytopenia 11.19 9.54 4 291302 16 63197700
Natural killer cell count 11.19 9.54 4 291302 16 63197700
Maternal exposure before pregnancy 11.19 9.54 11 291295 7592 63190124
Blood lactic acid increased 11.19 9.54 63 291243 7023 63190693
Hypercapnia 11.17 9.54 52 291254 5379 63192337
Anti-neuronal antibody positive 11.10 9.54 3 291303 3 63197713
Patient restraint 11.10 9.54 3 291303 3 63197713
Antidepressant drug level decreased 11.10 9.54 3 291303 3 63197713
Benzodiazepine drug level 11.10 9.54 3 291303 3 63197713
Increased appetite 11.09 9.54 79 291227 9551 63188165
Blood creatine increased 11.06 9.54 53 291253 5548 63192168
Non-small cell lung cancer 11.06 9.54 39 291267 3556 63194160
Incision site complication 11.05 9.54 14 291292 612 63197104
Osteoradionecrosis 11.04 9.54 7 291299 119 63197597
Toxicologic test abnormal 10.98 9.54 15 291291 706 63197010
Fear of injection 10.97 9.54 10 291296 7154 63190562
Drug resistance 10.97 9.54 61 291245 22872 63174844
Pathogen resistance 10.96 9.54 8 291298 6390 63191326
Hallucination, tactile 10.95 9.54 10 291296 299 63197417
Pressure of speech 10.90 9.54 15 291291 711 63197005
Vision blurred 10.87 9.54 521 290785 91403 63106313
Carbohydrate antigen 125 increased 10.87 9.54 33 291273 2783 63194933
Dysmetropsia 10.86 9.54 6 291300 78 63197638
Stillbirth 10.85 9.54 9 291297 6741 63190975
Device adhesion issue 10.83 9.54 5 291301 5136 63192580
Hyponatriuria 10.82 9.54 4 291302 18 63197698
Red cell distribution width increased 10.80 9.54 84 291222 10440 63187276
Cerebral atrophy 10.79 9.54 49 291257 5017 63192699
Systolic hypertension 10.78 9.54 12 291294 457 63197259
Antidepressant drug level increased 10.76 9.54 10 291296 306 63197410
Tuberculosis 10.76 9.54 22 291284 11189 63186527
Clonus 10.75 9.54 46 291260 4590 63193126
Hyponatraemic syndrome 10.74 9.54 13 291293 542 63197174
Sneezing 10.73 9.54 45 291261 18173 63179543
Regressive behaviour 10.72 9.54 8 291298 179 63197537
Hypoaesthesia oral 10.71 9.54 99 291207 12934 63184782
Troponin T increased 10.67 9.54 20 291286 1234 63196482
Delusional perception 10.66 9.54 9 291297 242 63197474
Cardiovascular disorder 10.65 9.54 24 291282 11788 63185928
Dependence 10.65 9.54 27 291279 2050 63195666
Affective ambivalence 10.65 9.54 4 291302 19 63197697
Delusional disorder, unspecified type 10.60 9.54 11 291295 386 63197330
False positive investigation result 10.58 9.54 14 291292 639 63197077
Tri-iodothyronine free decreased 10.55 9.54 10 291296 314 63197402
Drug diversion 10.52 9.54 17 291289 931 63196785
Eczema 10.51 9.54 96 291210 32195 63165521
Transplant rejection 10.47 9.54 21 291285 10759 63186957
Hepatocellular injury 10.46 9.54 78 291228 27303 63170413
Bone marrow failure 10.46 9.54 85 291221 29205 63168511
Gastric ulcer 10.41 9.54 66 291240 23971 63173745
Basophil count increased 10.40 9.54 17 291289 940 63196776
Limbic encephalitis 10.37 9.54 10 291296 321 63197395
Tongue movement disturbance 10.37 9.54 10 291296 321 63197395
Schizoaffective disorder bipolar type 10.27 9.54 7 291299 135 63197581
Abortion spontaneous complete 10.25 9.54 3 291303 5 63197711
Malignant catatonia 10.24 9.54 8 291298 192 63197524
Hypoglycaemia 10.24 9.54 204 291102 59861 63137855
C-reactive protein 10.23 9.54 47 291259 4835 63192881
Lupus-like syndrome 10.15 9.54 36 291270 15259 63182457
Intestinal strangulation 10.11 9.54 6 291300 90 63197626
Balance disorder 10.09 9.54 479 290827 83943 63113773
Adrenal insufficiency 10.09 9.54 45 291261 17870 63179846
Malnutrition 10.07 9.54 111 291195 15187 63182529
Product storage error 10.06 9.54 35 291271 14921 63182795
Drug withdrawal convulsions 10.04 9.54 21 291285 1404 63196312
Disinhibition 10.03 9.54 16 291290 867 63196849
Macrophages increased 10.02 9.54 4 291302 23 63197693
Antidepressant discontinuation syndrome 10.02 9.54 5 291301 52 63197664
Pneumonia 10.01 9.54 1895 289411 454872 62742844
Blood immunoglobulin M decreased 10.00 9.54 17 291289 971 63196745
Wound infection fungal 9.97 9.54 7 291299 142 63197574
Hypertransaminasaemia 9.94 9.54 58 291248 6551 63191165
Asthma 9.92 9.54 481 290825 127080 63070636
Injection site haemorrhage 9.90 9.54 68 291238 24246 63173470
Intestinal perforation 9.90 9.54 91 291215 11872 63185844
Morbihan disease 9.88 9.54 4 291302 24 63197692
Discoloured vomit 9.88 9.54 16 291290 878 63196838
Post-traumatic stress disorder 9.88 9.54 49 291257 5202 63192514
Klebsiella bacteraemia 9.87 9.54 23 291283 1655 63196061
Skin cancer 9.85 9.54 24 291282 11471 63186245
Parkinsonian gait 9.79 9.54 12 291294 507 63197209
Cardiac failure chronic 9.78 9.54 4 291302 4414 63193302
White blood cell count decreased 9.77 9.54 753 290553 138351 63059365
Muscle tension dysphonia 9.76 9.54 8 291298 206 63197510
Cytomegalovirus viraemia 9.76 9.54 7 291299 5642 63192074
Gastric disorder 9.75 9.54 117 291189 37252 63160464
Platelet morphology abnormal 9.75 9.54 4 291302 25 63197691
Blood magnesium decreased 9.74 9.54 98 291208 13100 63184616
Compulsions 9.73 9.54 8 291298 207 63197509
Antidepressant drug level above therapeutic 9.73 9.54 11 291295 426 63197290
Brain herniation 9.73 9.54 38 291268 3639 63194077
Verbal abuse 9.72 9.54 6 291300 97 63197619
Gallbladder cholesterolosis 9.70 9.54 15 291291 791 63196925
Sarcoidosis 9.70 9.54 11 291295 7111 63190605
Cellulitis 9.70 9.54 294 291012 81664 63116052
Ventricular arrhythmia 9.68 9.54 39 291267 3789 63193927
Culture urine positive 9.67 9.54 38 291268 3649 63194067
Gout 9.66 9.54 30 291276 13241 63184475
Rhinorrhoea 9.65 9.54 228 291078 65349 63132367
Impulsive behaviour 9.64 9.54 22 291284 1561 63196155
Drug dose omission by device 9.61 9.54 5 291301 4796 63192920
Aplastic anaemia 9.61 9.54 76 291230 9493 63188223
Road traffic accident 9.61 9.54 228 291078 36404 63161312
Dysaesthesia pharynx 9.60 9.54 7 291299 151 63197565
Drug withdrawal syndrome neonatal 9.59 9.54 26 291280 2055 63195661
Sensory loss 9.57 9.54 80 291226 10158 63187558
Synovial cyst 9.57 9.54 21 291285 10412 63187304

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sopor 859.15 10.31 579 152129 11557 34792666
Agitation 434.71 10.31 846 151862 56553 34747670
Neuroleptic malignant syndrome 433.08 10.31 460 152248 17474 34786749
Drug abuse 425.97 10.31 1168 151540 97928 34706295
Catatonia 334.77 10.31 231 152477 4794 34799429
Intentional self-injury 317.99 10.31 345 152363 13426 34790797
Bradyphrenia 301.96 10.31 213 152495 4585 34799638
Sedation 275.10 10.31 396 152312 20610 34783613
Psychotic disorder 273.22 10.31 428 152280 24024 34780199
Aggression 263.42 10.31 548 152160 38416 34765807
Completed suicide 253.99 10.31 973 151735 97195 34707028
Suicide attempt 249.21 10.31 537 152171 38579 34765644
Delirium 231.56 10.31 560 152148 43431 34760792
Somnolence 223.77 10.31 1020 151688 110096 34694127
Extrapyramidal disorder 180.73 10.31 251 152457 12629 34791594
Anxiety 170.71 10.31 872 151836 98556 34705667
Schizophrenia 169.18 10.31 199 152509 8467 34795756
Confusional state 157.13 10.31 1123 151585 143037 34661186
Hallucination, auditory 153.57 10.31 223 152485 11694 34792529
Dysarthria 137.39 10.31 398 152310 34384 34769839
Intentional overdose 136.74 10.31 461 152247 43213 34761010
Drug dependence 134.63 10.31 315 152393 23902 34780321
Drug withdrawal syndrome 134.03 10.31 279 152429 19555 34784668
Overdose 132.20 10.31 763 151945 90296 34713927
Interstitial lung disease 117.01 10.31 70 152638 65212 34739011
Restlessness 115.88 10.31 307 152401 25175 34779048
Muscle rigidity 109.07 10.31 178 152530 10340 34793883
Mental status changes 102.89 10.31 383 152325 37700 34766523
Suicidal ideation 99.94 10.31 395 152313 39993 34764230
Respiratory depression 95.46 10.31 216 152492 16029 34788194
Disorientation 94.90 10.31 340 152368 32848 34771375
Febrile neutropenia 92 10.31 958 151750 135891 34668332
Abnormal behaviour 91.26 10.31 278 152430 24691 34779532
Tachycardia 90.26 10.31 657 152051 84115 34720108
Depressed level of consciousness 89.60 10.31 398 152310 42443 34761780
Parkinsonism 86.12 10.31 139 152569 7999 34796224
Delusion 83.33 10.31 176 152532 12459 34791764
Seizure 81.64 10.31 757 151951 104100 34700123
Toxicity to various agents 80.41 10.31 1275 151433 199087 34605136
Ataxia 77.87 10.31 181 152527 13672 34790551
COVID-19 72.56 10.31 143 152565 77407 34726816
Akathisia 70.61 10.31 127 152581 7982 34796241
Joint swelling 69.47 10.31 96 152612 59794 34744429
Psychomotor hyperactivity 65.75 10.31 136 152572 9486 34794737
Bradykinesia 65.60 10.31 83 152625 3810 34800413
Withdrawal syndrome 63.82 10.31 157 152551 12298 34791925
Serotonin syndrome 62.88 10.31 211 152497 19722 34784501
Mental impairment 62.60 10.31 139 152569 10183 34794040
Sedation complication 62.43 10.31 56 152652 1721 34802502
Salivary hypersecretion 62.42 10.31 125 152583 8519 34795704
Unresponsive to stimuli 62.14 10.31 262 152446 27307 34776916
Rheumatoid arthritis 61.77 10.31 46 152662 38192 34766031
Hallucination 61.77 10.31 411 152297 51087 34753136
Product dose omission issue 61.56 10.31 291 152417 119420 34684803
Acute kidney injury 60.82 10.31 952 151756 304036 34500187
Pruritus 60.34 10.31 368 152340 141613 34662610
Speech disorder 60.16 10.31 247 152461 25439 34778784
Myelosuppression 59.77 10.31 7 152701 19258 34784965
Blood creatine phosphokinase increased 58.08 10.31 365 152343 44492 34759731
Dystonia 58.02 10.31 139 152569 10706 34793517
Granulocytopenia 57.37 10.31 103 152605 6464 34797759
Paradoxical drug reaction 57.35 10.31 72 152636 3279 34800944
Paranoia 54.45 10.31 145 152563 11923 34792300
Miosis 54.04 10.31 125 152583 9410 34794813
Anaemia 52.88 10.31 710 151998 232625 34571598
Dyskinesia 52.86 10.31 216 152492 22197 34782026
Drug interaction 52.57 10.31 1325 151383 224621 34579602
Arthralgia 52.57 10.31 482 152226 169559 34634664
Psoriasis 51.56 10.31 56 152652 38756 34765467
Needle fatigue 50.59 10.31 37 152671 844 34803379
Renal impairment 50.20 10.31 227 152481 94286 34709937
Peripheral swelling 50.14 10.31 169 152539 76372 34727851
Refusal of treatment by patient 49.27 10.31 83 152625 4949 34799274
Antipsychotic drug level decreased 48.01 10.31 38 152670 979 34803244
Delusion of grandeur 47.71 10.31 40 152668 1120 34803103
Gait spastic 47.59 10.31 39 152669 1057 34803166
Multiple organ dysfunction syndrome 47.51 10.31 173 152535 76393 34727830
Negativism 47.50 10.31 27 152681 392 34803831
Treatment noncompliance 47.12 10.31 245 152463 27855 34776368
Cytomegalovirus infection 46.84 10.31 28 152680 26107 34778116
Hypokinesia 46.63 10.31 113 152595 8767 34795456
Prostate cancer 46.53 10.31 63 152645 39586 34764637
Poverty of speech 46.37 10.31 22 152686 214 34804009
Movement disorder 46.28 10.31 138 152570 12110 34792113
Major depression 45.55 10.31 76 152632 4496 34799727
Relapsing-remitting multiple sclerosis 44.84 10.31 37 152671 1013 34803210
Stupor 44.59 10.31 59 152649 2832 34801391
Electrocardiogram QT prolonged 44.47 10.31 319 152389 40633 34763590
Psoriatic arthropathy 43.51 10.31 16 152692 19782 34784441
Multiple drug therapy 42.53 10.31 26 152682 435 34803788
Antipsychotic drug level increased 42.24 10.31 67 152641 3798 34800425
Treatment failure 42.05 10.31 88 152620 46609 34757614
Sinus tachycardia 41.49 10.31 168 152540 17192 34787031
Coma 41.34 10.31 341 152367 45337 34758886
Irritability 41.21 10.31 215 152493 24475 34779748
Withdrawal catatonia 40.85 10.31 16 152692 92 34804131
Rash 40.47 10.31 707 152001 222045 34582178
Hepatic function abnormal 40.46 10.31 83 152625 44280 34759943
Drug ineffective 40.13 10.31 1611 151097 455140 34349083
Homicide 39.61 10.31 33 152675 916 34803307
Bladder cancer 39.59 10.31 11 152697 16267 34787956
Rhinitis perennial 39.59 10.31 22 152686 305 34803918
Synovitis 39.25 10.31 7 152701 14059 34790164
Tremor 39.07 10.31 541 152167 82046 34722177
Hyperkalaemia 39.06 10.31 163 152545 69226 34734997
Psychotic symptom 39.06 10.31 43 152665 1700 34802523
Drug screen positive 38.56 10.31 65 152643 3878 34800345
Insomnia 38.52 10.31 653 152055 103254 34700969
Victim of child abuse 38.20 10.31 32 152676 895 34803328
Faecaloma 37.92 10.31 77 152631 5300 34798923
Incoherent 37.83 10.31 69 152639 4383 34799840
Dyspnoea 37.50 10.31 1309 151399 375473 34428750
Depression 37.01 10.31 613 152095 96485 34707738
Pneumonia aspiration 36.94 10.31 311 152397 41592 34762631
Anxiolytic therapy 36.80 10.31 13 152695 53 34804170
Self-injurious ideation 36.80 10.31 41 152667 1643 34802580
Adjustment disorder 36.67 10.31 35 152673 1166 34803057
Anaphylactic shock 36.55 10.31 12 152696 15929 34788294
Confabulation 35.99 10.31 16 152692 132 34804091
Dysphoria 35.53 10.31 47 152661 2255 34801968
Drug withdrawal convulsions 35.37 10.31 34 152674 1143 34803080
Diet refusal 35.21 10.31 20 152688 290 34803933
Drug therapy enhancement 35.18 10.31 13 152695 62 34804161
Visceral congestion 35.14 10.31 26 152682 604 34803619
Parathyroid gland enlargement 35.08 10.31 16 152692 141 34804082
Affective disorder 35.08 10.31 66 152642 4294 34799929
Respiratory arrest 34.94 10.31 226 152482 27817 34776406
Iatrogenic injury 34.58 10.31 30 152678 881 34803342
Cardiac failure 34.44 10.31 245 152463 91003 34713220
Drug reaction with eosinophilia and systemic symptoms 34.33 10.31 57 152651 32955 34771268
Hypersensitivity 33.97 10.31 144 152564 60891 34743332
Cardiac failure congestive 33.70 10.31 219 152489 83051 34721172
Upper respiratory fungal infection 33.60 10.31 16 152692 157 34804066
Hepatic cytolysis 33.08 10.31 11 152697 14485 34789738
Mental disorder 33.08 10.31 143 152565 15066 34789157
Sexually inappropriate behaviour 32.84 10.31 23 152685 489 34803734
Pain in extremity 32.73 10.31 374 152334 126139 34678084
Status epilepticus 32.51 10.31 125 152583 12489 34791734
Affect lability 32.47 10.31 58 152650 3625 34800598
Thinking abnormal 32.12 10.31 78 152630 6059 34798164
Myocardial infarction 32.09 10.31 356 152352 120729 34683494
Oropharyngeal spasm 31.08 10.31 15 152693 152 34804071
Muscle spasticity 30.99 10.31 75 152633 5813 34798410
Angioedema 30.74 10.31 74 152634 37300 34766923
Hyperammonaemic encephalopathy 30.68 10.31 44 152664 2280 34801943
Neologism 30.50 10.31 8 152700 7 34804216
Oral discharge 30.44 10.31 14 152694 126 34804097
Cholestasis 30.44 10.31 44 152664 26904 34777319
Psychotic behaviour 30.31 10.31 25 152683 684 34803539
Hyperprolactinaemia 30.07 10.31 36 152672 1560 34802663
Lethargy 30.02 10.31 293 152415 40829 34763394
Mania 29.39 10.31 100 152608 9411 34794812
Mutism 29.09 10.31 27 152681 868 34803355
Hangover 29.04 10.31 29 152679 1022 34803201
Aplastic anaemia 29.02 10.31 101 152607 9615 34794608
Monoparesis 28.92 10.31 43 152665 2303 34801920
Hypertonic bladder 28.68 10.31 38 152670 1826 34802397
Forced expiratory volume 28.66 10.31 13 152695 113 34804110
Impulsive behaviour 28.64 10.31 41 152667 2121 34802102
Haematuria 28.55 10.31 117 152591 49949 34754274
Acute myocardial infarction 28.52 10.31 129 152579 53590 34750633
Arthropathy 28.40 10.31 46 152662 26861 34777362
Micturition urgency 28.03 10.31 77 152631 6448 34797775
Nervousness 27.78 10.31 119 152589 12487 34791736
Myocardial fibrosis 27.64 10.31 30 152678 1167 34803056
Anger 27.60 10.31 114 152594 11770 34792453
Off label use 27.35 10.31 1527 151181 417997 34386226
Bone marrow failure 27.29 10.31 54 152654 29199 34775024
Epidural lipomatosis 27.15 10.31 28 152680 1026 34803197
Intentional product use issue 26.99 10.31 152 152556 59664 34744559
Transplant rejection 26.95 10.31 6 152702 10305 34793918
Substance abuse 26.91 10.31 84 152624 7557 34796666
Arthritis 26.63 10.31 61 152647 31285 34772938
Amnesia 26.60 10.31 203 152505 26360 34777863
Diarrhoea 26.56 10.31 1413 151295 388499 34415724
Anaphylactic reaction 26.53 10.31 64 152644 32237 34771986
Logorrhoea 26.44 10.31 42 152666 2384 34801839
Gastrointestinal haemorrhage 26.36 10.31 253 152455 88224 34715999
Coronary artery disease 26.24 10.31 115 152593 48190 34756033
Social avoidant behaviour 26.13 10.31 48 152660 3066 34801157
Erythema 25.97 10.31 255 152453 88525 34715698
Pleurothotonus 25.75 10.31 29 152679 1176 34803047
Parkinsonian gait 25.57 10.31 20 152688 506 34803717
Panic attack 25.57 10.31 95 152613 9337 34794886
Myocarditis 25.55 10.31 123 152585 13559 34790664
Psychomotor retardation 25.42 10.31 52 152656 3598 34800625
Urinary incontinence 24.68 10.31 154 152554 18720 34785503
Child abuse 24.67 10.31 18 152690 409 34803814
Balance disorder 24.65 10.31 279 152429 40375 34763848
Orgasmic sensation decreased 24.51 10.31 10 152698 65 34804158
Poisoning 24.36 10.31 112 152596 12114 34792109
Depressed mood 24.26 10.31 156 152552 19161 34785062
Panic reaction 24.14 10.31 31 152677 1444 34802779
Oedema peripheral 24.11 10.31 373 152335 119439 34684784
Alcohol withdrawal syndrome 23.96 10.31 31 152677 1455 34802768
Pathogen resistance 23.83 10.31 6 152702 9476 34794747
Hallucination, visual 23.79 10.31 146 152562 17645 34786578
Rhabdomyolysis 23.67 10.31 424 152284 67739 34736484
Failure to thrive 23.63 10.31 87 152621 8514 34795709
Priapism 23.54 10.31 61 152647 4933 34799290
Communication disorder 23.29 10.31 41 152667 2533 34801690
Urticaria 23.28 10.31 168 152540 62209 34742014
Therapeutic product effect decreased 23.23 10.31 76 152632 34667 34769556
Persecutory delusion 23.22 10.31 41 152667 2539 34801684
Epstein-Barr virus infection 23.10 10.31 3 152705 7625 34796598
Tubulointerstitial nephritis 23.09 10.31 35 152673 20989 34783234
Injection site pain 22.97 10.31 90 152618 38915 34765308
Eczema 22.96 10.31 28 152680 18408 34785815
Hyperosmolar state 22.94 10.31 17 152691 396 34803827
C-reactive protein abnormal 22.91 10.31 5 152703 8705 34795518
Hyperreflexia 22.71 10.31 46 152662 3160 34801063
Contraindicated product administered 22.42 10.31 37 152671 21444 34782779
Memory impairment 22.22 10.31 288 152420 43030 34761193
Inappropriate antidiuretic hormone secretion 21.93 10.31 112 152596 12641 34791582
Bipolar disorder 21.79 10.31 49 152659 3620 34800603
Full blood count abnormal 21.77 10.31 148 152560 18520 34785703
Ascites 21.74 10.31 117 152591 46454 34757769
Loss of consciousness 21.65 10.31 493 152215 82174 34722049
Fear 21.64 10.31 97 152611 10379 34793844
Drug resistance 21.58 10.31 51 152657 25876 34778347
Disturbance in attention 21.52 10.31 190 152518 25755 34778468
Liver disorder 21.50 10.31 73 152635 32924 34771299
Disorganised speech 21.46 10.31 23 152685 882 34803341
Plasma cell myeloma 21.36 10.31 279 152429 41758 34762465
Atrial fibrillation 21.07 10.31 392 152316 122001 34682222
Cerebral haemorrhage 20.96 10.31 80 152628 34857 34769366
Haematotoxicity 20.96 10.31 5 152703 8189 34796034
COVID-19 pneumonia 20.89 10.31 26 152682 16941 34787282
Middle insomnia 20.57 10.31 71 152637 6731 34797492
Drug intolerance 20.54 10.31 164 152544 59406 34744817
Hypoglycaemia 20.46 10.31 147 152561 54493 34749730
Thrombocytopenia 20.39 10.31 523 152185 155724 34648499
Soliloquy 20.25 10.31 16 152692 411 34803812
Blood creatine phosphokinase 20.25 10.31 10 152698 107 34804116
Sexual dysfunction 20.12 10.31 67 152641 6236 34797987
Drug eruption 20.09 10.31 35 152673 19863 34784360
Melaena 19.97 10.31 83 152625 35297 34768926
Negative thoughts 19.93 10.31 19 152689 632 34803591
Flight of ideas 19.79 10.31 15 152693 362 34803861
Blood sodium decreased 19.65 10.31 130 152578 16121 34788102
Visual acuity reduced 19.62 10.31 25 152683 16124 34788099
Illusion 19.58 10.31 21 152687 806 34803417
Proteinuria 19.55 10.31 32 152676 18610 34785613
Cough 19.47 10.31 503 152205 149637 34654586
Oculogyric crisis 19.45 10.31 29 152679 1557 34802666
Pyrexia 19.36 10.31 1225 151483 331788 34472435
Angina pectoris 19.35 10.31 71 152637 31292 34772931
Nephropathy toxic 19.24 10.31 16 152692 12572 34791651
Jaundice 19.13 10.31 73 152635 31809 34772414
Premature ejaculation 19.11 10.31 10 152698 122 34804101
Cerebral infarction 19.09 10.31 59 152649 27396 34776827
Pulmonary fibrosis 18.90 10.31 32 152676 18364 34785859
Intentional product misuse 18.88 10.31 292 152416 45319 34758904
Purple glove syndrome 18.87 10.31 8 152700 58 34804165
Schizoaffective disorder 18.82 10.31 26 152682 1301 34802922
Cerebrovascular accident 18.81 10.31 259 152449 84552 34719671
Sexual relationship change 18.64 10.31 6 152702 17 34804206
Rhinalgia 18.62 10.31 23 152685 1030 34803193
Generalised tonic-clonic seizure 18.57 10.31 157 152551 21017 34783206
Injection site swelling 18.44 10.31 14 152694 11513 34792710
Growth hormone deficiency 18.38 10.31 13 152695 281 34803942
Cognitive disorder 18.35 10.31 199 152509 28494 34775729
Thought insertion 18.27 10.31 5 152703 6 34804217
Renal disorder 18.26 10.31 54 152654 25426 34778797
Dysphagia 18.24 10.31 378 152330 62003 34742220
Hyperventilation 18.23 10.31 39 152669 2785 34801438
Herpes zoster 18.02 10.31 83 152625 34316 34769907
Appendicitis 17.91 10.31 23 152685 14784 34789439
Haematuria traumatic 17.79 10.31 11 152697 188 34804035
Immune reconstitution inflammatory syndrome 17.75 10.31 8 152700 8751 34795472
Basal cell carcinoma 17.73 10.31 37 152671 19621 34784602
Infection 17.62 10.31 285 152423 90630 34713593
Emotional disorder 17.57 10.31 60 152648 5656 34798567
Perseveration 17.55 10.31 9 152699 105 34804118
Aspiration 17.54 10.31 102 152606 12092 34792131
Infusion related reaction 17.41 10.31 148 152560 52909 34751314
Nasal congestion 17.16 10.31 48 152660 23009 34781214
Neutropenic sepsis 17.05 10.31 21 152687 13746 34790477
Floppy infant 17.04 10.31 9 152699 112 34804111
Staring 16.78 10.31 26 152682 1444 34802779
Fall 16.65 10.31 1063 151645 201822 34602401
Oesophageal carcinoma 16.63 10.31 10 152698 9294 34794929
Porphyria acute 16.45 10.31 13 152695 334 34803889
Dyspnoea exertional 16.42 10.31 116 152592 43163 34761060
Pressure of speech 16.22 10.31 15 152693 480 34803743
Hypoxia 16.15 10.31 334 152374 54761 34749462
Homicidal ideation 16.13 10.31 36 152672 2646 34801577
Loose associations 16.04 10.31 7 152701 55 34804168
Skin ulcer 15.98 10.31 47 152661 22169 34782054
Coordination abnormal 15.96 10.31 71 152637 7573 34796650
Antipsychotic drug level above therapeutic 15.78 10.31 23 152685 1210 34803013
Testicular atrophy 15.75 10.31 16 152692 576 34803647
Hypomania 15.71 10.31 33 152675 2326 34801897
Altered state of consciousness 15.68 10.31 161 152547 22732 34781491
Venous angioma of brain 15.54 10.31 6 152702 33 34804190
Apnoea 15.53 10.31 64 152644 6600 34797623
Glycosylated haemoglobin increased 15.52 10.31 16 152692 11344 34792879
Ventricular fibrillation 15.49 10.31 50 152658 22904 34781319
Rebound effect 15.44 10.31 40 152668 3234 34800989
Chronic kidney disease 15.37 10.31 111 152597 41099 34763124
Megacolon 15.31 10.31 28 152680 1782 34802441
Tachyphrenia 15.27 10.31 23 152685 1246 34802977
Somatic hallucination 15.25 10.31 6 152702 35 34804188
Posturing 15.25 10.31 15 152693 519 34803704
Self esteem decreased 15.13 10.31 15 152693 524 34803699
Suicidal behaviour 15.07 10.31 25 152683 1472 34802751
Blood urea nitrogen/creatinine ratio decreased 14.97 10.31 6 152702 37 34804186
Immunosuppressant drug level increased 14.90 10.31 4 152704 6051 34798172
Fluid replacement 14.81 10.31 10 152698 200 34804023
Slow speech 14.77 10.31 22 152686 1180 34803043
Pneumocystis jirovecii pneumonia 14.69 10.31 41 152667 19669 34784554
Dystonic tremor 14.43 10.31 10 152698 209 34804014
Juvenile idiopathic arthritis 14.38 10.31 28 152680 1869 34802354
Frequent bowel movements 14.32 10.31 21 152687 12766 34791457
Hypogammaglobulinaemia 14.28 10.31 8 152700 7732 34796491
Injection site erythema 14.28 10.31 30 152678 15869 34788354
Myalgia 14.27 10.31 270 152438 83840 34720383
Tuberculosis 14.26 10.31 10 152698 8567 34795656
Renal failure 14.22 10.31 448 152260 130109 34674114
Manic symptom 14.20 10.31 8 152700 114 34804109
Shoshin beriberi 14.17 10.31 7 152701 75 34804148
Skin necrosis 14.15 10.31 4 152704 5849 34798374
Colitis ulcerative 14.15 10.31 32 152676 16488 34787735
Drop attacks 14.15 10.31 15 152693 568 34803655
Gingival oedema 14.11 10.31 4 152704 6 34804217
Feeling jittery 14.09 10.31 44 152664 3959 34800264
Spasmodic dysphonia 13.98 10.31 10 152698 220 34804003
Lip swelling 13.89 10.31 31 152677 16049 34788174
End stage renal disease 13.87 10.31 11 152697 8850 34795373
Hepatic failure 13.87 10.31 91 152617 34440 34769783
Derealisation 13.85 10.31 15 152693 582 34803641
Staphylococcal infection 13.84 10.31 85 152623 32675 34771548
Cardiac disorder 13.84 10.31 121 152587 43005 34761218
Head banging 13.63 10.31 9 152699 173 34804050
Pneumonia 13.62 10.31 1382 151326 361245 34442978
Myelodysplastic syndrome 13.55 10.31 41 152667 19167 34785056
Hepatocellular carcinoma 13.52 10.31 8 152700 7501 34796722
Electroencephalogram abnormal 13.51 10.31 32 152676 2446 34801777
Reduced facial expression 13.45 10.31 20 152688 1071 34803152
Hypercapnia 13.38 10.31 45 152663 4210 34800013
Vascular stenosis 13.20 10.31 9 152699 183 34804040
Nephrolithiasis 13.18 10.31 78 152630 30255 34773968
Hypocalcaemia 13.08 10.31 58 152650 24231 34779992
Progressive multifocal leukoencephalopathy 13.06 10.31 14 152694 9750 34794473
Congenital pulmonary valve atresia 13.05 10.31 6 152702 54 34804169
Malaise 13.05 10.31 671 152037 185154 34619069
Poor sucking reflex 13.00 10.31 11 152697 312 34803911
Haemophagocytic lymphohistiocytosis 12.94 10.31 23 152685 12950 34791273
Grandiosity 12.85 10.31 11 152697 317 34803906
Blood alkaline phosphatase decreased 12.83 10.31 17 152691 817 34803406
Lactic acidosis 12.80 10.31 94 152614 34678 34769545
Muscle mass 12.75 10.31 10 152698 254 34803969
Skin laceration 12.75 10.31 96 152612 12413 34791810
Blood osmolarity increased 12.74 10.31 12 152696 393 34803830
Lung disorder 12.67 10.31 94 152614 34602 34769621
Obesity 12.66 10.31 98 152610 12780 34791443
Mood swings 12.63 10.31 68 152640 7833 34796390
Hallucination, olfactory 12.62 10.31 9 152699 197 34804026
Nerve degeneration 12.55 10.31 9 152699 199 34804024
Clumsiness 12.45 10.31 25 152683 1707 34802516
Emotional distress 12.44 10.31 110 152598 14916 34789307
Hepatotoxicity 12.38 10.31 50 152658 21435 34782788
Hyperchloraemia 12.24 10.31 13 152695 493 34803730
Vasculitis 12.22 10.31 19 152689 11277 34792946
Prescribed overdose 12.17 10.31 84 152624 10563 34793660
Blood prolactin increased 12.17 10.31 25 152683 1735 34802488
Waxy flexibility 12.12 10.31 7 152701 105 34804118
Skin toxicity 12.08 10.31 3 152705 4781 34799442
Bronchopulmonary aspergillosis 12.07 10.31 29 152679 14630 34789593
Pulmonary tuberculosis 11.96 10.31 3 152705 4751 34799472
Neutrophil count increased 11.94 10.31 121 152587 17025 34787198
Lithiasis 11.93 10.31 6 152702 67 34804156
Gastrointestinal disorder 11.91 10.31 93 152615 33855 34770368
Therapeutic response decreased 11.90 10.31 77 152631 29236 34774987
Obsessive-compulsive disorder 11.86 10.31 52 152656 5512 34798711
Grimacing 11.84 10.31 10 152698 283 34803940
Drooling 11.74 10.31 37 152671 3345 34800878
Peritonitis bacterial 11.74 10.31 6 152702 6104 34798119
Pseudomonal bacteraemia 11.74 10.31 22 152686 1427 34802796
Ureteric obstruction 11.68 10.31 20 152688 1208 34803015
Neonatal tachypnoea 11.63 10.31 8 152700 165 34804058
Selective mutism 11.62 10.31 6 152702 71 34804152
Renal cancer 11.62 10.31 10 152698 7725 34796498
Dehydration 11.58 10.31 686 152022 129283 34674940
Delirium tremens 11.53 10.31 14 152694 616 34803607
Nephrotic syndrome 11.52 10.31 9 152699 7294 34796929
Creutzfeldt-Jakob disease 11.49 10.31 5 152703 39 34804184
Acute stress disorder 11.47 10.31 8 152700 169 34804054
Drug hypersensitivity 11.46 10.31 266 152442 80263 34723960
Septic shock 11.45 10.31 233 152475 71601 34732622
Echolalia 11.40 10.31 10 152698 298 34803925
Transient acantholytic dermatosis 11.40 10.31 7 152701 118 34804105
Arachnoid cyst 11.40 10.31 9 152699 231 34803992
Physical assault 11.36 10.31 19 152689 1126 34803097
Cytotoxic oedema 11.31 10.31 8 152700 173 34804050
Tangentiality 11.30 10.31 7 152701 120 34804103
Central nervous system lesion 11.28 10.31 57 152651 6406 34797817
Pulse pressure increased 11.25 10.31 3 152705 3 34804220
Thought withdrawal 11.25 10.31 3 152705 3 34804220
Anorectal operation 11.25 10.31 3 152705 3 34804220
Hypertensive crisis 11.21 10.31 13 152695 8738 34795485
Mucormycosis 11.17 10.31 6 152702 5936 34798287
Feelings of worthlessness 11.10 10.31 10 152698 309 34803914
Pollakiuria 11.03 10.31 133 152575 19541 34784682
Autoimmune haemolytic anaemia 11.01 10.31 3 152705 4493 34799730
Device issue 11.00 10.31 16 152692 9761 34794462
Platelet transfusion 10.94 10.31 22 152686 1504 34802719
Foetal exposure during pregnancy 10.89 10.31 110 152598 37991 34766232
Body temperature increased 10.89 10.31 120 152588 17248 34786975
Anal incontinence 10.87 10.31 65 152643 7784 34796439
Cerebral atrophy 10.83 10.31 44 152664 4508 34799715
Dissociation 10.82 10.31 23 152685 1635 34802588
Pneumonitis chemical 10.81 10.31 8 152700 186 34804037
Impaired reasoning 10.77 10.31 7 152701 131 34804092
Impaired quality of life 10.76 10.31 6 152702 5812 34798411
Lymphocyte count abnormal 10.73 10.31 19 152689 1179 34803044
Drug ineffective for unapproved indication 10.66 10.31 154 152554 23561 34780662
General physical health deterioration 10.62 10.31 455 152253 127814 34676409
Drug-induced liver injury 10.58 10.31 78 152630 28754 34775469
Injection site pruritus 10.52 10.31 9 152699 6974 34797249
Periorbital pain 10.51 10.31 4 152704 21 34804202
Thrombosis 10.51 10.31 156 152552 50302 34753921
Erectile dysfunction 10.49 10.31 137 152571 20500 34783723
Thrombotic microangiopathy 10.46 10.31 19 152689 10611 34793612
Crying 10.44 10.31 52 152656 5810 34798413
Drug tolerance 10.44 10.31 32 152676 2850 34801373
Hypophagia 10.40 10.31 155 152553 23867 34780356
Haematochezia 10.35 10.31 142 152566 46392 34757831

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sopor 2747.20 9.53 1775 364468 31235 79346910
Drug abuse 1495.34 9.53 2680 363563 160011 79218134
Completed suicide 828.54 9.53 2747 363496 243020 79135125
Neuroleptic malignant syndrome 798.55 9.53 798 365445 26761 79351384
Intentional self-injury 752.53 9.53 834 365409 31585 79346560
Agitation 695.56 9.53 1463 364780 98252 79279893
Suicide attempt 625.78 9.53 1257 364986 81675 79296470
Bradyphrenia 624.97 9.53 462 365781 10178 79367967
Somnolence 541.88 9.53 2354 363889 236627 79141518
Catatonia 529.63 9.53 387 365856 8369 79369776
Delirium 477.23 9.53 1141 365102 83486 79294659
Intentional overdose 469.85 9.53 1305 364938 104655 79273490
Overdose 423.08 9.53 1822 364421 182384 79195761
Psychotic disorder 359.28 9.53 666 365577 40736 79337409
Toxicity to various agents 315.03 9.53 3137 363106 418403 78959742
Drug withdrawal syndrome 311.99 9.53 567 365676 34151 79343994
Coma 311.26 9.53 1094 365149 99555 79278590
Aggression 297.97 9.53 697 365546 50261 79327884
Confusional state 291.87 9.53 2474 363769 315523 79062622
Anxiety 264.24 9.53 2000 364243 246512 79131633
Extrapyramidal disorder 261.59 9.53 414 365829 22265 79355880
Drug dependence 259.83 9.53 577 365666 40192 79337953
Serotonin syndrome 259.04 9.53 612 365631 44415 79333730
Disorientation 243.29 9.53 737 365506 62039 79316106
Restlessness 240.92 9.53 607 365636 45885 79332260
Suicidal ideation 240.51 9.53 835 365408 75505 79302640
Sedation 237.70 9.53 647 365596 51248 79326897
Respiratory depression 223.02 9.53 431 365812 27199 79350946
Hallucination, auditory 217.27 9.53 362 365881 20331 79357814
Drug interaction 211.98 9.53 2871 363372 412312 78965833
Tachycardia 200.40 9.53 1451 364792 176317 79201828
Depressed level of consciousness 199.09 9.53 926 365317 95726 79282419
Dysarthria 194.53 9.53 718 365525 66904 79311241
Joint swelling 192.96 9.53 679 365564 287967 79090178
Poisoning 190.42 9.53 383 365860 24889 79353256
Febrile neutropenia 188.92 9.53 1753 364490 229246 79148899
Muscle rigidity 186.66 9.53 331 365912 19551 79358594
Akathisia 185.66 9.53 265 365978 12994 79365151
Schizophrenia 185.22 9.53 287 365956 15153 79362992
Speech disorder 184.22 9.53 610 365633 53835 79324310
Bradykinesia 176.48 9.53 201 366042 7842 79370303
Interstitial lung disease 171.97 9.53 158 366085 112442 79265703
Delusion 162.90 9.53 317 365926 20106 79358039
Psychomotor hyperactivity 162.70 9.53 284 365959 16565 79361580
Arthralgia 160.81 9.53 1765 364478 570038 78808107
Contraindicated product administered 160.55 9.53 299 365944 157239 79220906
Drug intolerance 159.18 9.53 648 365595 263471 79114674
Mental status changes 154.03 9.53 663 365580 66296 79311849
Abnormal behaviour 152.92 9.53 440 365803 35981 79342164
Drug ineffective 151.36 9.53 3797 362446 1077116 78301029
COVID-19 147.17 9.53 315 365928 157359 79220786
Mania 143.91 9.53 282 365961 17978 79360167
Rash 140.50 9.53 1843 364400 576515 78801630
Pneumonia aspiration 140.39 9.53 645 365598 66322 79311823
Withdrawal syndrome 139.52 9.53 351 365892 26503 79351642
Arthropathy 134.78 9.53 393 365850 176718 79201427
Hypersensitivity 134.34 9.53 683 365560 261556 79116589
Therapeutic product effect decreased 131.05 9.53 355 365888 163508 79214637
Seizure 128.63 9.53 1380 364863 187454 79190691
Synovitis 123.23 9.53 323 365920 150411 79227734
Mydriasis 123.04 9.53 259 365984 17384 79360761
Treatment failure 122.08 9.53 389 365854 170097 79208048
Tremor 120.54 9.53 1253 364990 168830 79209315
Psychomotor retardation 118.19 9.53 144 366099 6040 79372105
Rheumatoid arthritis 115.45 9.53 528 365715 207942 79170203
Unresponsive to stimuli 115.21 9.53 535 365708 55253 79322892
Respiratory arrest 114.54 9.53 546 365697 57004 79321141
Salivary hypersecretion 112.49 9.53 220 366023 14004 79364141
Myelosuppression 110.06 9.53 25 366218 40271 79337874
Electrocardiogram QT prolonged 109.50 9.53 751 365492 89635 79288510
Hypokinesia 108.45 9.53 258 365985 18802 79359343
Hallucination 103.61 9.53 712 365531 85033 79293112
Pain 100.65 9.53 2463 363780 701339 78676806
Slow speech 99.32 9.53 86 366157 2392 79375753
Dystonia 98.17 9.53 267 365976 21132 79357013
Off label use 98.14 9.53 3300 362943 903915 78474230
Paranoia 96.80 9.53 250 365993 19182 79358963
Status epilepticus 95.13 9.53 292 365951 24749 79353396
Mutism 94.42 9.53 82 366161 2290 79375855
Stupor 92.78 9.53 135 366108 6737 79371408
Sinus tachycardia 91.53 9.53 374 365869 36534 79341611
Miosis 91.22 9.53 215 366028 15574 79362571
Depression 91.02 9.53 1450 364793 215340 79162805
Cytomegalovirus infection 89.22 9.53 42 366201 42602 79335543
Infusion related reaction 85.60 9.53 662 365581 229575 79148570
Psoriasis 85.22 9.53 177 366066 89410 79288735
Derealisation 84.47 9.53 66 366177 1583 79376562
Dyskinesia 83.51 9.53 417 365826 44356 79333789
Swelling 83.46 9.53 617 365626 216094 79162051
Parkinsonism 82.24 9.53 213 366030 16371 79361774
Drug hypersensitivity 82.09 9.53 927 365316 297989 79080156
Mobility decreased 81.13 9.53 288 365955 121887 79256258
Product dose omission issue 81.07 9.53 736 365507 246801 79131344
Systemic lupus erythematosus 80.17 9.53 286 365957 120863 79257282
Granulocytopenia 79.93 9.53 168 366075 11263 79366882
Mental disorder 79.86 9.53 320 365923 30982 79347163
Substance abuse 79.86 9.53 160 366083 10366 79367779
Pruritus 77.52 9.53 1310 364933 393338 78984807
Hypothermia 77.06 9.53 255 365988 22491 79355654
Drooling 76.40 9.53 114 366129 5820 79372325
Hand deformity 75.15 9.53 236 366007 103683 79274462
Alopecia 74.84 9.53 690 365553 230665 79147480
Peripheral swelling 74.08 9.53 836 365407 268781 79109364
Acute kidney injury 72.41 9.53 1824 364419 517580 78860565
Mental impairment 72.33 9.53 222 366021 18814 79359331
Gastric pH decreased 72.07 9.53 47 366196 839 79377306
Persecutory delusion 71.52 9.53 100 366143 4809 79373336
Loss of consciousness 70.35 9.53 1123 365120 166820 79211325
Anaphylactic shock 70.01 9.53 39 366204 35957 79342188
Hepatic function abnormal 69.06 9.53 145 366098 72962 79305183
Ataxia 68.77 9.53 262 365981 24777 79353368
Dissociation 67.87 9.53 88 366155 3933 79374212
Tardive dyskinesia 67.77 9.53 150 366093 10421 79367724
Erythema 67.54 9.53 677 365566 222613 79155532
Bezoar 67.32 9.53 72 366171 2616 79375529
Pemphigus 67.28 9.53 233 366010 99349 79278796
Cardiac arrest 66.63 9.53 1136 365107 170960 79207185
Pain in extremity 64.62 9.53 1232 365011 363306 79014839
Homicide 64.09 9.53 49 366194 1137 79377008
Injection site erythema 63.55 9.53 168 366075 78029 79300116
Hyperammonaemic encephalopathy 63.19 9.53 93 366150 4689 79373456
Blood creatine phosphokinase increased 63.00 9.53 519 365724 65571 79312574
Major depression 62.81 9.53 132 366111 8848 79369297
Device expulsion 61.40 9.53 21 366222 25840 79352305
Hallucinations, mixed 61.11 9.53 112 366131 6787 79371358
Feeling of despair 61.05 9.53 70 366173 2751 79375394
Renal impairment 60.83 9.53 449 365794 157334 79220811
Hallucination, visual 59.75 9.53 303 365940 32426 79345719
Antipsychotic drug level increased 59.59 9.53 102 366141 5855 79372290
Incontinence 59.34 9.53 171 366072 13993 79364152
Infection 58.95 9.53 769 365474 240943 79137202
Disorganised speech 58.92 9.53 60 366183 2057 79376088
Delusion of grandeur 58.00 9.53 50 366193 1382 79376763
Hypoxia 57.95 9.53 727 365516 102516 79275629
Withdrawal catatonia 57.92 9.53 25 366218 180 79377965
Drug eruption 57.70 9.53 70 366173 43865 79334280
Hepatic enzyme increased 57.17 9.53 549 365694 182061 79196084
Injection site pain 56.75 9.53 356 365887 129482 79248663
Prostate cancer 56.57 9.53 42 366201 33226 79344919
Skin necrosis 56.35 9.53 8 366235 18079 79360066
Hyperreflexia 56.05 9.53 121 366122 8264 79369881
Cogwheel rigidity 55.94 9.53 70 366173 3018 79375127
Depersonalisation/derealisation disorder 55.92 9.53 55 366188 1807 79376338
Refusal of treatment by patient 55.87 9.53 126 366117 8865 79369280
Emotional disorder 53.93 9.53 167 366076 14220 79363925
Anaemia 53.87 9.53 1594 364649 443421 78934724
Abdominal discomfort 53.25 9.53 820 365423 249907 79128238
Tenosynovitis 53.14 9.53 5 366238 15549 79362596
C-reactive protein increased 52.74 9.53 361 365882 128666 79249479
Fall 52.10 9.53 2738 363505 484891 78893254
Anti-cyclic citrullinated peptide antibody positive 50.64 9.53 203 366040 82940 79295205
Hepatic cytolysis 50.56 9.53 31 366212 27120 79351025
Coma scale abnormal 49.94 9.53 118 366125 8560 79369585
Apnoea 49.71 9.53 142 366101 11562 79366583
Computerised tomogram thorax 49.67 9.53 29 366214 421 79377724
Therapeutic response decreased 49.62 9.53 150 366093 66703 79311442
Brain injury 49.17 9.53 140 366103 11377 79366768
Affective disorder 48.84 9.53 114 366129 8205 79369940
Visceral congestion 48.40 9.53 38 366205 918 79377227
Arthritis 48.16 9.53 319 365924 114561 79263584
Insomnia 48.05 9.53 1470 364773 243700 79134445
Red blood cell sedimentation rate increased 47.83 9.53 86 366157 45856 79332289
Disturbance in attention 47.38 9.53 397 365846 50404 79327741
Computerised tomogram thorax abnormal 47.32 9.53 57 366186 2362 79375783
Cardiac failure congestive 46.76 9.53 423 365820 141979 79236166
Therapeutic product effect incomplete 46.40 9.53 421 365822 141224 79236921
Feeling jittery 46.24 9.53 147 366096 12694 79365451
Incoherent 45.81 9.53 106 366137 7586 79370559
Electrocardiogram QRS complex prolonged 45.59 9.53 131 366112 10702 79367443
Negativism 45.20 9.53 35 366208 828 79377317
Somatic symptom disorder 45.15 9.53 57 366186 2480 79375665
Mood swings 45.05 9.53 196 366047 19684 79358461
Angioedema 44.83 9.53 188 366055 75847 79302298
Irritability 44.67 9.53 333 365910 40811 79337334
Drug withdrawal convulsions 44.56 9.53 53 366190 2167 79375978
Bladder cancer 44.41 9.53 17 366226 19509 79358636
Skin ulcer 44.25 9.53 116 366127 54034 79324111
Cardio-respiratory arrest 44.08 9.53 722 365521 107788 79270357
Needle fatigue 43.84 9.53 35 366208 867 79377278
Myocardial infarction 43.71 9.53 589 365654 183540 79194605
Neutropenic sepsis 43.70 9.53 36 366207 27028 79351117
Bone marrow failure 43.69 9.53 107 366136 51000 79327145
Intentional product misuse 43.53 9.53 646 365597 94519 79283626
Dehydration 43.41 9.53 1468 364775 246719 79131426
Lethargy 43.32 9.53 567 365676 80725 79297420
Blood prolactin increased 43.22 9.53 71 366172 3940 79374205
Acute myocardial infarction 42.67 9.53 195 366048 76841 79301304
Amnesia 42.49 9.53 460 365783 62597 79315548
Poverty of speech 42.28 9.53 29 366214 565 79377580
Antipsychotic drug level decreased 42.17 9.53 39 366204 1185 79376960
Dysphagia 41.87 9.53 791 365452 121345 79256800
Gastrointestinal haemorrhage 41.73 9.53 455 365788 147264 79230881
Enthesopathy 41.68 9.53 3 366240 11605 79366540
Osmolar gap increased 41.44 9.53 17 366226 106 79378039
Cardiac failure 41.36 9.53 483 365760 154359 79223786
Panic attack 41.31 9.53 220 366023 23996 79354149
Myocardial fibrosis 41.24 9.53 45 366198 1673 79376472
Malaise 41.07 9.53 1835 364408 488034 78890111
Respiratory acidosis 41.05 9.53 129 366114 11071 79367074
Urinary incontinence 41.01 9.53 325 365918 40584 79337561
Gait spastic 40.96 9.53 38 366205 1159 79376986
Schizoaffective disorder 40.94 9.53 50 366193 2102 79376043
Injection site swelling 40.82 9.53 98 366145 47034 79331111
Pleurothotonus 40.82 9.53 54 366189 2462 79375683
Myocardial depression 40.45 9.53 27 366216 502 79377643
Red blood cell sedimentation rate abnormal 40.35 9.53 23 366220 20940 79357205
Logorrhoea 40.11 9.53 72 366171 4293 79373852
Intentional product use issue 40.05 9.53 476 365767 151636 79226509
Injection site pruritus 39.82 9.53 84 366159 42199 79335946
Basal cell carcinoma 39.78 9.53 69 366174 37306 79340839
Haematotoxicity 39.72 9.53 11 366232 15508 79362637
Glossodynia 39.37 9.53 295 365948 103042 79275103
Transplant rejection 39.36 9.53 20 366223 19417 79358728
Electroencephalogram abnormal 39.32 9.53 81 366162 5353 79372792
Drop attacks 39.05 9.53 35 366208 1020 79377125
Psychotic behaviour 38.94 9.53 36 366207 1093 79377052
Narcotic bowel syndrome 38.94 9.53 21 366222 259 79377886
Blood sodium decreased 38.89 9.53 274 365969 32981 79345164
Hyponatraemia 38.84 9.53 1081 365162 176767 79201378
Communication disorder 38.27 9.53 68 366175 4022 79374123
Echolalia 37.94 9.53 23 366220 359 79377786
Multiple organ dysfunction syndrome 37.83 9.53 361 365882 119885 79258260
Generalised tonic-clonic seizure 37.73 9.53 337 365906 43573 79334572
H1N1 influenza 37.72 9.53 52 366191 2467 79375678
Osteoporosis 37.64 9.53 125 366118 53987 79324158
Paradoxical drug reaction 37.41 9.53 94 366149 7091 79371054
Impaired quality of life 37.19 9.53 10 366233 14376 79363769
Aplastic anaemia 37.17 9.53 172 366071 17733 79360412
Pathogen resistance 37.02 9.53 10 366233 14332 79363813
Rhinitis perennial 36.94 9.53 22 366221 332 79377813
Encephalitis autoimmune 36.85 9.53 49 366194 2245 79375900
Drug screen positive 36.60 9.53 84 366159 5979 79372166
Nervousness 36.59 9.53 271 365972 33144 79345001
Osteonecrosis of jaw 36.56 9.53 91 366152 43135 79335010
Headache 36.41 9.53 2549 363694 651223 78726922
Anxiolytic therapy 36.17 9.53 13 366230 53 79378092
Drug therapy enhancement 36.17 9.53 13 366230 53 79378092
Depressed mood 36.14 9.53 361 365882 48119 79330026
Victim of child abuse 36.04 9.53 32 366211 921 79377224
Suicidal behaviour 35.69 9.53 58 366185 3189 79374956
Alcohol abuse 35.40 9.53 77 366166 5286 79372859
Pericarditis 35.37 9.53 307 365936 103929 79274216
Sexually inappropriate behaviour 35.04 9.53 25 366218 520 79377625
Decorticate posture 35.02 9.53 21 366222 321 79377824
Sinusitis 34.81 9.53 660 365583 194841 79183304
Treatment noncompliance 34.62 9.53 380 365863 51888 79326257
Pneumocystis jirovecii pneumonia 34.61 9.53 60 366183 32448 79345697
Obsessive-compulsive disorder 34.55 9.53 81 366162 5846 79372299
Rhabdomyolysis 34.35 9.53 665 365578 102466 79275679
Dyspnoea 34.10 9.53 3432 362811 853593 78524552
Ulcer 34.08 9.53 53 366190 29919 79348226
Inappropriate antidiuretic hormone secretion 33.87 9.53 222 366021 26091 79352054
Mood altered 33.83 9.53 167 366076 17680 79360465
Maternal exposure during pregnancy 33.78 9.53 433 365810 136105 79242040
Bone erosion 33.76 9.53 20 366223 17827 79360318
Febrile bone marrow aplasia 33.76 9.53 9 366234 13011 79365134
Drug reaction with eosinophilia and systemic symptoms 33.60 9.53 166 366077 64078 79314067
Myoclonus 33.58 9.53 230 366013 27430 79350715
Psoriatic arthropathy 33.49 9.53 215 366028 77784 79300361
Product use issue 33.29 9.53 722 365521 209100 79169045
Victim of sexual abuse 33.28 9.53 24 366219 508 79377637
Coronary artery disease 33.20 9.53 171 366072 65303 79312842
Panniculitis 33.14 9.53 8 366235 12363 79365782
Pneumonia viral 33.13 9.53 105 366138 9053 79369092
Rhinalgia 32.68 9.53 47 366196 2320 79375825
Blood pH decreased 32.66 9.53 69 366174 4642 79373503
Melaena 32.62 9.53 156 366087 60734 79317411
Injection site reaction 32.58 9.53 135 366108 54650 79323495
Failure to thrive 32.58 9.53 124 366119 11720 79366425
Oropharyngeal spasm 32.55 9.53 22 366221 418 79377727
Nasopharyngitis 32.54 9.53 902 365341 252979 79125166
Deep vein thrombosis postoperative 32.45 9.53 116 366127 10636 79367509
Pneumonia 32.35 9.53 2602 363641 657644 78720501
Parkinsonian gait 32.26 9.53 30 366213 918 79377227
Psychotic symptom 32.16 9.53 50 366193 2647 79375498
Diabetes insipidus 32.10 9.53 73 366170 5164 79372981
Accidental exposure to product by child 31.80 9.53 52 366191 2874 79375271
Relapsing-remitting multiple sclerosis 31.71 9.53 37 366206 1482 79376663
Facet joint syndrome 31.64 9.53 119 366124 11183 79366962
Altered state of consciousness 31.55 9.53 324 365919 43498 79334647
Staring 31.49 9.53 49 366194 2596 79375549
Propofol infusion syndrome 31.31 9.53 42 366201 1941 79376204
Tubulointerstitial nephritis 31.17 9.53 82 366161 38153 79339992
Patient uncooperative 31.11 9.53 26 366217 688 79377457
Soft tissue disorder 31.05 9.53 57 366186 3458 79374687
Hypertonia 30.96 9.53 88 366155 7144 79371001
Mouth ulceration 30.80 9.53 83 366160 38311 79339834
Waxy flexibility 30.61 9.53 18 366225 265 79377880
Loss of personal independence in daily activities 30.58 9.53 312 365931 102268 79275877
Homicidal ideation 30.47 9.53 56 366187 3401 79374744
Obesity 30.40 9.53 270 365973 34855 79343290
Plasma cell myeloma 30.29 9.53 376 365867 52883 79325262
Behaviour disorder 30.19 9.53 80 366163 6233 79371912
Wrong patient received product 30.14 9.53 66 366177 4552 79373593
Hyperchloraemia 29.80 9.53 31 366212 1090 79377055
Aspiration 29.65 9.53 176 366067 19982 79358163
Hyperprolactinaemia 29.58 9.53 66 366177 4610 79373535
Haemophagocytic lymphohistiocytosis 29.52 9.53 34 366209 21803 79356342
Pancreatic fibrosis 29.50 9.53 13 366230 99 79378046
Hypoglycaemia 29.46 9.53 311 365932 101283 79276862
Immunodeficiency 29.31 9.53 34 366209 21734 79356411
Myocardial reperfusion injury 29.28 9.53 13 366230 101 79378044
Anaphylactic reaction 29.15 9.53 245 365998 83498 79294647
Sleep disorder 29.05 9.53 554 365689 85123 79293022
Drug resistance 29.03 9.53 98 366145 42115 79336030
Hyperkalaemia 28.96 9.53 361 365882 114037 79264108
Haematuria 28.92 9.53 191 366052 68645 79309500
Joint injury 28.88 9.53 63 366180 31272 79346873
Rheumatoid factor positive 28.83 9.53 159 366084 59680 79318465
Cholestasis 28.80 9.53 132 366111 51977 79326168
Blister 28.77 9.53 381 365862 119095 79259050
Parosmia 28.73 9.53 84 366159 6930 79371215
Condition aggravated 28.66 9.53 1949 364294 499175 78878970
CSF oligoclonal band present 28.66 9.53 20 366223 401 79377744
Faecaloma 28.52 9.53 117 366126 11447 79366698
Self-injurious ideation 28.44 9.53 56 366187 3582 79374563
Lip dry 28.32 9.53 143 366100 15275 79362870
Nicotine dependence 28.29 9.53 28 366215 927 79377218
Bradycardia 28.21 9.53 819 365424 134738 79243407
Crying 28.21 9.53 192 366051 22851 79355294
Device issue 27.99 9.53 51 366192 27057 79351088
Anger 27.98 9.53 154 366089 17008 79361137
Atelectasis 27.94 9.53 248 365995 32009 79346136
Myelodysplastic syndrome 27.86 9.53 61 366182 30240 79347905
Cataract 27.82 9.53 169 366074 61951 79316194
Acute psychosis 27.57 9.53 60 366183 4120 79374025
Cough 27.52 9.53 1390 364853 365399 79012746
Monoparesis 27.39 9.53 54 366189 3457 79374688
Head injury 27.24 9.53 277 365966 37092 79341053
Emotional distress 27.12 9.53 292 365951 39677 79338468
Bronchiectasis 27.00 9.53 38 366205 22348 79355797
Parathyroid gland enlargement 26.96 9.53 14 366229 159 79377986
Urinary retention 26.91 9.53 387 365856 56243 79321902
Angina pectoris 26.86 9.53 134 366109 51598 79326547
Kidney transplant rejection 26.72 9.53 7 366236 10239 79367906
Alcohol interaction 26.68 9.53 65 366178 4809 79373336
Forced expiratory volume 26.62 9.53 12 366231 97 79378048
Colorectal cancer 26.53 9.53 4 366239 8643 79369502
Gastric cancer 26.46 9.53 7 366236 10172 79367973
Menstrual disorder 26.40 9.53 58 366185 4009 79374136
Thinking abnormal 26.27 9.53 125 366118 13036 79365109
Lower respiratory tract infection 26.27 9.53 426 365817 128794 79249351
Poisoning deliberate 26.18 9.53 162 366081 18666 79359479
Social avoidant behaviour 26.14 9.53 64 366179 4750 79373395
Breast cancer female 26.03 9.53 10 366233 11451 79366694
Child abuse 26.03 9.53 19 366224 410 79377735
Foot deformity 26.03 9.53 44 366199 24030 79354115
Change of bowel habit 26.01 9.53 46 366197 2711 79375434
Balance disorder 26 9.53 616 365627 98241 79279904
Thrombocytopenia 25.95 9.53 976 365267 264283 79113862
Dyspnoea exertional 25.88 9.53 265 365978 86808 79291337
Phagophobia 25.87 9.53 10 366233 52 79378093
Confabulation 25.66 9.53 20 366223 478 79377667
Accidental death 25.41 9.53 59 366184 4232 79373913
Impaired driving ability 25.27 9.53 68 366175 5347 79372798
Alcohol withdrawal syndrome 24.99 9.53 38 366205 1973 79376172
Oedema peripheral 24.96 9.53 927 365316 251361 79126784
Iatrogenic injury 24.85 9.53 33 366210 1510 79376635
Drug screen false positive 24.81 9.53 28 366215 1081 79377064
Inflammation 24.81 9.53 293 365950 93460 79284685
PCO2 increased 24.63 9.53 36 366207 1804 79376341
Hyperthyroidism 24.56 9.53 40 366203 22169 79355976
Impulsive behaviour 24.34 9.53 46 366197 2854 79375291
Device malfunction 24.31 9.53 38 366205 21410 79356735
Acute generalised exanthematous pustulosis 24.27 9.53 26 366217 17228 79360917
Visual acuity reduced 24.18 9.53 63 366180 29406 79348739
Polyarthritis 24.05 9.53 13 366230 12189 79365956
Fear 23.89 9.53 178 366065 21808 79356337
Movement disorder 23.83 9.53 210 366033 27049 79351096
Oral discharge 23.74 9.53 15 366228 253 79377892
Galactorrhoea 23.67 9.53 52 366191 3594 79374551
Mitochondrial DNA mutation 23.64 9.53 18 366225 415 79377730
Prescribed overdose 23.54 9.53 272 365971 37611 79340534
Macrocytosis 23.44 9.53 45 366198 2825 79375320
Neologism 23.43 9.53 7 366236 13 79378132
Orgasmic sensation decreased 23.41 9.53 9 366234 46 79378099
Pulmonary tuberculosis 23.32 9.53 4 366239 7861 79370284
Encephalopathy 23.26 9.53 437 365806 66960 79311185
Rapid eye movements sleep abnormal 23.18 9.53 15 366228 264 79377881
Solar urticaria 23.11 9.53 11 366232 102 79378043
Upper respiratory tract infection 22.96 9.53 288 365955 90880 79287265
Transplant dysfunction 22.96 9.53 3 366240 7218 79370927
Psychiatric decompensation 22.93 9.53 54 366189 3909 79374236
Compartment syndrome 22.90 9.53 63 366180 5019 79373126
Morbid thoughts 22.81 9.53 23 366220 779 79377366
Accidental overdose 22.75 9.53 280 365963 39301 79338844
Aspergillus infection 22.64 9.53 33 366210 19128 79359017
Fluid retention 22.63 9.53 208 366035 69601 79308544
Device difficult to use 22.62 9.53 17 366226 13368 79364777
Apallic syndrome 22.62 9.53 25 366218 943 79377202
PO2 increased 22.62 9.53 32 366211 1556 79376589
Rash pruritic 22.54 9.53 215 366028 71414 79306731
Coeliac disease 22.51 9.53 12 366231 11339 79366806
Epidural lipomatosis 22.51 9.53 28 366215 1200 79376945
Renal disorder 22.48 9.53 108 366135 41997 79336148
Gait disturbance 22.47 9.53 1167 365076 206339 79171806
Wound 22.31 9.53 387 365856 115792 79262353
Medication error 22.31 9.53 441 365802 68201 79309944
Bipolar disorder 22.29 9.53 82 366161 7625 79370520
Epstein-Barr virus infection 22.27 9.53 20 366223 14396 79363749
Creatinine renal clearance decreased 22.18 9.53 33 366210 18969 79359176
Soliloquy 22.14 9.53 21 366222 659 79377486
Bronchopulmonary aspergillosis 22.09 9.53 43 366200 22251 79355894
Restless legs syndrome 22.02 9.53 163 366080 19929 79358216
Herpes zoster 21.99 9.53 298 365945 92785 79285360
Hypophagia 21.94 9.53 311 365932 45056 79333089
Oral pain 21.90 9.53 233 366010 31565 79346580
Coma scale 21.82 9.53 9 366234 57 79378088
Illusion 21.78 9.53 33 366210 1708 79376437
Diarrhoea 21.74 9.53 3634 362609 876855 78501290
Finger deformity 21.73 9.53 4 366239 7470 79370675
Respiratory rate decreased 21.67 9.53 63 366180 5180 79372965
Eczema 21.61 9.53 105 366138 40713 79337432
Oesophageal carcinoma 21.57 9.53 12 366231 11072 79367073
Disinhibition 21.54 9.53 41 366202 2557 79375588
Testicular atrophy 21.54 9.53 16 366227 355 79377790
Thrombosis 21.43 9.53 265 365978 83835 79294310
Atrial fibrillation 21.42 9.53 719 365524 197167 79180978
Tachyphrenia 21.31 9.53 36 366207 2044 79376101
BK virus infection 21.16 9.53 7 366236 8797 79369348
Tendonitis 21.07 9.53 49 366194 23781 79354364
Premature ejaculation 21.07 9.53 9 366234 63 79378082
Screaming 21.05 9.53 52 366191 3881 79374264
Hypercapnia 20.94 9.53 89 366154 8846 79369299
Pressure of speech 20.92 9.53 27 366216 1201 79376944
Drug abuser 20.89 9.53 68 366175 5945 79372200
Osteonecrosis 20.83 9.53 73 366170 31022 79347123
Cytomegalovirus infection reactivation 20.83 9.53 7 366236 8709 79369436
Knee arthroplasty 20.79 9.53 115 366128 43133 79335012
Sluggishness 20.78 9.53 72 366171 6500 79371645
Small intestinal obstruction 20.77 9.53 204 366039 27068 79351077
Neurosensory hypoacusis 20.69 9.53 13 366230 217 79377928
Skin exfoliation 20.65 9.53 158 366085 54942 79323203
Unintentional medical device removal 20.63 9.53 5 366238 7707 79370438
Joint effusion 20.34 9.53 32 366211 17982 79360163
Vasculitis 20.34 9.53 54 366189 25048 79353097
Wrong technique in product usage process 20.28 9.53 229 366014 73646 79304499
Haematochezia 20.20 9.53 282 365961 87363 79290782
Hyperosmolar state 20.19 9.53 20 366223 663 79377482
Feeling of body temperature change 20.13 9.53 62 366181 5264 79372881
Device adhesion issue 20.12 9.53 4 366239 7071 79371074
Cerebral infarction 20.07 9.53 125 366118 45551 79332594
Drug clearance decreased 19.98 9.53 46 366197 3281 79374864
Mucormycosis 19.89 9.53 7 366236 8462 79369683
Feelings of worthlessness 19.82 9.53 18 366225 534 79377611
Chronic kidney disease 19.80 9.53 201 366042 65953 79312192
Cerebral microhaemorrhage 19.79 9.53 13 366230 235 79377910
Echopraxia 19.76 9.53 8 366235 48 79378097
Disease recurrence 19.75 9.53 120 366123 43989 79334156
Peripheral venous disease 19.74 9.53 133 366110 15776 79362369
Coronary artery stenosis 19.67 9.53 17 366226 12467 79365678
Endophthalmitis 19.66 9.53 3 366240 6425 79371720
Skin reaction 19.65 9.53 27 366216 16041 79362104
Hangover 19.61 9.53 35 366208 2077 79376068
Cytomegalovirus viraemia 19.55 9.53 18 366225 12803 79365342
Diet refusal 19.50 9.53 22 366221 849 79377296
Priapism 19.46 9.53 55 366188 4450 79373695
Proteinuria 19.38 9.53 80 366163 32422 79345723
Muscle disorder 19.35 9.53 64 366179 5643 79372502
Drug screen negative 19.34 9.53 14 366229 298 79377847
Skin toxicity 19.31 9.53 7 366236 8307 79369838
Colitis ulcerative 19.20 9.53 88 366155 34654 79343491
Mitochondrial encephalomyopathy 19.20 9.53 7 366236 30 79378115
Partial seizures 19.20 9.53 87 366156 8891 79369254
COVID-19 pneumonia 19.14 9.53 68 366175 28781 79349364
Neutrophil count increased 19.14 9.53 213 366030 29183 79348962
Tuberculosis 19.13 9.53 25 366218 15173 79362972
Discomfort 19.12 9.53 435 365808 125182 79252963
Cognitive disorder 19.09 9.53 438 365805 69488 79308657
Thrombotic microangiopathy 19.05 9.53 40 366203 20129 79358016
Gallbladder disorder 19.03 9.53 153 366090 19187 79358958
Bradypnoea 18.87 9.53 66 366177 5986 79372159
Grandiosity 18.87 9.53 18 366225 569 79377576
End stage renal disease 18.82 9.53 17 366226 12203 79365942
Electrocardiogram J wave 18.73 9.53 8 366235 56 79378089
Injection site bruising 18.65 9.53 111 366132 40891 79337254
Bronchitis 18.61 9.53 457 365786 130187 79247958
Injury 18.61 9.53 477 365766 77019 79301126
Loose associations 18.61 9.53 8 366235 57 79378088
Cerebral atrophy 18.59 9.53 80 366163 7995 79370150
Multiple-drug resistance 18.57 9.53 85 366158 8723 79369422
Autonomic nervous system imbalance 18.53 9.53 55 366188 4575 79373570
Clumsiness 18.52 9.53 43 366200 3084 79375061
Rhesus antigen positive 18.50 9.53 10 366233 124 79378021
Micturition urgency 18.36 9.53 110 366133 12531 79365614
Leukocytosis 18.33 9.53 291 365952 43164 79334981
Hallucination, tactile 18.31 9.53 18 366225 591 79377554
Hyperhidrosis 18.27 9.53 861 365382 150631 79227514
Device use error 18.24 9.53 5 366238 7096 79371049
Immune reconstitution inflammatory syndrome 18.23 9.53 22 366221 13819 79364326
Coronary artery bypass 18.16 9.53 3 366240 6059 79372086
Cannabinoid hyperemesis syndrome 18.15 9.53 8 366235 61 79378084
Hepatocellular injury 18.06 9.53 136 366107 47457 79330688
Attention deficit hyperactivity disorder 17.97 9.53 44 366199 3265 79374880
Lip swelling 17.96 9.53 112 366131 40799 79337346
Benzodiazepine drug level increased 17.94 9.53 12 366231 224 79377921
Monocyte count decreased 17.85 9.53 43 366200 3158 79374987
Self-medication 17.80 9.53 58 366185 5074 79373071
Upper respiratory fungal infection 17.73 9.53 14 366229 341 79377804
Respiratory failure 17.71 9.53 1008 365235 179903 79198242
Metabolic encephalopathy 17.63 9.53 86 366157 9061 79369084
Nephrolithiasis 17.61 9.53 158 366085 53133 79325012
Dementia 17.60 9.53 182 366061 24477 79353668
Joint destruction 17.60 9.53 3 366240 5922 79372223
Acute coronary syndrome 17.47 9.53 45 366198 21088 79357057
Renal ischaemia 17.42 9.53 24 366219 1138 79377007
Blood bicarbonate decreased 17.41 9.53 58 366185 5133 79373012
Femur fracture 17.39 9.53 105 366138 38547 79339598
Haematuria traumatic 17.38 9.53 11 366232 186 79377959
Infective pulmonary exacerbation of cystic fibrosis 17.38 9.53 20 366223 12831 79365314
Respiratory distress 17.37 9.53 370 365873 57969 79320176
Abortion spontaneous 17.36 9.53 73 366170 29434 79348711
Protein C increased 17.35 9.53 9 366234 102 79378043
Cerebrovascular accident 17.33 9.53 562 365681 154730 79223415
Skin maceration 17.31 9.53 8 366235 69 79378076
Hepatocellular carcinoma 17.22 9.53 10 366233 9011 79369134
Rectal polyp 17.15 9.53 29 366214 1648 79376497
Shock haemorrhagic 17.14 9.53 42 366201 20018 79358127
Liver disorder 17.04 9.53 232 366011 72185 79305960
Frustration tolerance decreased 17.02 9.53 74 366169 7428 79370717
Enuresis 17.01 9.53 42 366201 3134 79375011
Sneezing 16.99 9.53 41 366202 19642 79358503
Gastric ulcer 16.94 9.53 89 366154 33816 79344329
Ear infection 16.86 9.53 91 366152 34341 79343804
Blood creatine phosphokinase 16.78 9.53 10 366233 151 79377994
Nodule 16.77 9.53 52 366191 22942 79355203
Therapeutic product ineffective 16.77 9.53 31 366212 1891 79376254
Abulia 16.71 9.53 22 366221 998 79377147
Clonus 16.71 9.53 69 366174 6771 79371374
Breast cancer stage I 16.69 9.53 5 366238 6695 79371450
Haemoglobin urine 16.67 9.53 10 366233 153 79377992
Coordination abnormal 16.52 9.53 136 366107 17176 79360969
Schizophreniform disorder 16.50 9.53 10 366233 156 79377989
Nephropathy toxic 16.49 9.53 44 366199 20375 79357770
Blood osmolarity increased 16.48 9.53 18 366225 670 79377475
Hypochloraemia 16.48 9.53 36 366207 2479 79375666
Aphasia 16.47 9.53 304 365939 46428 79331717
Muscle mass 16.40 9.53 15 366228 449 79377696
Glaucoma 16.40 9.53 42 366201 19719 79358426
Tachypnoea 16.40 9.53 222 366021 31841 79346304
Sacroiliitis 16.38 9.53 46 366197 3708 79374437
Affect lability 16.37 9.53 98 366145 11161 79366984
Urine abnormality 16.36 9.53 78 366165 8141 79370004
Arthritis bacterial 16.34 9.53 11 366232 9155 79368990
Hypernatraemia 16.28 9.53 118 366125 14333 79363812
Posturing 16.17 9.53 22 366221 1031 79377114
Renal failure 16.15 9.53 756 365487 200212 79177933
Brain death 16.08 9.53 60 366183 5617 79372528
Polyneuropathy 15.98 9.53 57 366186 24094 79354051
Dysphoria 15.97 9.53 53 366190 4681 79373464
Drug ineffective for unapproved indication 15.92 9.53 327 365916 50911 79327234
Laryngeal injury 15.88 9.53 5 366238 12 79378133
Drug-induced liver injury 15.86 9.53 211 366032 65906 79312239
Pulmonary fibrosis 15.83 9.53 128 366115 43984 79334161
Therapy interrupted 15.81 9.53 82 366161 31259 79346886
Diaphragmatic rupture 15.79 9.53 11 366232 220 79377925
Premature delivery 15.78 9.53 55 366188 23412 79354733
Musculoskeletal stiffness 15.78 9.53 650 365593 174358 79203787
Oculogyric crisis 15.77 9.53 39 366204 2913 79375232
Manic symptom 15.76 9.53 9 366234 125 79378020
Nasal congestion 15.68 9.53 252 365991 76300 79301845
Sexual relationship change 15.59 9.53 5 366238 13 79378132
Pulseless electrical activity 15.59 9.53 115 366128 14045 79364100
Hepatitis 15.59 9.53 172 366071 55555 79322590
Autoimmune disorder 15.58 9.53 130 366113 16482 79361663
Renal cancer 15.51 9.53 20 366223 12206 79365939
Wrong drug 15.49 9.53 12 366231 284 79377861
Cardiac failure chronic 15.42 9.53 17 366226 11118 79367027
Thought insertion 15.40 9.53 6 366237 32 79378113
Pyrexia 15.37 9.53 2814 363429 675895 78702250
Gout 15.33 9.53 60 366183 24689 79353456
Inflammatory marker increased 15.31 9.53 16 366227 10724 79367421
Oxygen saturation abnormal 15.19 9.53 51 366192 4531 79373614
Somatic hallucination 15.18 9.53 7 366236 60 79378085
Bundle branch block right 15.14 9.53 96 366147 11155 79366990
Eye disorder 15.00 9.53 56 366187 23356 79354789
Inappropriate affect 14.97 9.53 26 366217 1510 79376635
Drug dose omission by device 14.97 9.53 5 366238 6245 79371900
Myositis 14.95 9.53 42 366201 19126 79359019
Water intoxication 14.75 9.53 18 366225 756 79377389
Granuloma 14.73 9.53 10 366233 8287 79369858
Rash erythematous 14.73 9.53 182 366061 57587 79320558
Sputum purulent 14.70 9.53 24 366219 1325 79376820
Urticaria 14.62 9.53 698 365545 184503 79193642
Nocardiosis 14.58 9.53 4 366239 5675 79372470
Uveitis 14.57 9.53 35 366208 16795 79361350
Erysipelas 14.55 9.53 17 366226 10833 79367312
Nephrotic syndrome 14.46 9.53 18 366225 11156 79366989
Lupus-like syndrome 14.37 9.53 26 366217 13831 79364314
Focal dyscognitive seizures 14.33 9.53 42 366201 3470 79374675
Blood lactic acid increased 14.32 9.53 104 366139 12640 79365505
Morose 14.29 9.53 6 366237 40 79378105
Extensor plantar response 14.20 9.53 28 366215 1793 79376352
Blood albumin increased 14.17 9.53 25 366218 1470 79376675
Diabetic ketoacidosis 14.17 9.53 95 366148 34027 79344118
Polydipsia 14.12 9.53 64 366179 6541 79371604
Soft tissue swelling 14.10 9.53 25 366218 1476 79376669
Libido decreased 14.06 9.53 55 366188 5266 79372879
Negative thoughts 14.05 9.53 24 366219 1375 79376770
Rales 14.05 9.53 46 366197 19955 79358190
Dependence 14.01 9.53 33 366210 2389 79375756
Dystonic tremor 13.97 9.53 10 366233 209 79377936
Differential white blood cell count abnormal 13.91 9.53 30 366213 2047 79376098
Platelet production decreased 13.91 9.53 4 366239 6 79378139
Generalised anxiety disorder 13.89 9.53 31 366212 2166 79375979
Bone density decreased 13.88 9.53 25 366218 13322 79364823
Hypomania 13.88 9.53 70 366173 7474 79370671
Dermatitis exfoliative generalised 13.86 9.53 8 366235 7233 79370912
Shoshin beriberi 13.83 9.53 7 366236 75 79378070
Pancytopenia 13.82 9.53 621 365622 165124 79213021
Appendicitis 13.81 9.53 49 366194 20745 79357400
Lymphocyte count decreased 13.78 9.53 299 365944 46990 79331155
Rhinorrhoea 13.78 9.53 256 365987 75818 79302327
Alcoholism 13.75 9.53 43 366200 3680 79374465
Respiratory tract infection 13.73 9.53 150 366093 48539 79329606
Autoimmune haemolytic anaemia 13.71 9.53 11 366232 8369 79369776
Blood lactic acid decreased 13.69 9.53 11 366232 275 79377870
Blunted affect 13.68 9.53 14 366229 483 79377662
Alcohol use 13.64 9.53 51 366192 4780 79373365
Hypervigilance 13.63 9.53 14 366229 485 79377660
Brain abscess 13.60 9.53 3 366240 4933 79373212
Dysphemia 13.58 9.53 41 366202 3443 79374702
Injection site rash 13.52 9.53 40 366203 17914 79360231
Nerve degeneration 13.52 9.53 11 366232 280 79377865
Regressive behaviour 13.45 9.53 9 366234 168 79377977
Growth hormone deficiency 13.45 9.53 13 366230 418 79377727
Stereotypy 13.40 9.53 19 366224 926 79377219
Anxiety disorder 13.35 9.53 46 366197 4141 79374004
Blood creatinine increased 13.33 9.53 579 365664 154478 79223667
Hypersexuality 13.30 9.53 26 366217 1654 79376491
Cutaneous vasculitis 13.29 9.53 11 366232 8241 79369904
Sputum discoloured 13.29 9.53 53 366190 21690 79356455
Sepsis 13.26 9.53 1061 365182 268367 79109778
Memory impairment 13.25 9.53 634 365609 111100 79267045
Drug specific antibody present 13.24 9.53 7 366236 6645 79371500
Surgery 13.22 9.53 92 366151 32674 79345471
Metabolic alkalosis 13.18 9.53 48 366195 4441 79373704
Prostate tenderness 13.16 9.53 3 366240 0 79378145
Aortic valve stenosis 13.10 9.53 4 366239 5290 79372855
Post procedural infection 13.07 9.53 20 366223 11364 79366781
Adrenal insufficiency 13.02 9.53 77 366166 28410 79349735
Carbohydrate antigen 125 increased 12.90 9.53 30 366213 2154 79375991
Delusional perception 12.88 9.53 12 366231 368 79377777
Blood gases abnormal 12.87 9.53 21 366222 1159 79376986
Paralysis 12.83 9.53 104 366139 13073 79365072
Hepatitis B reactivation 12.80 9.53 6 366237 6102 79372043
Fluid replacement 12.78 9.53 14 366229 523 79377622
Dysmetropsia 12.73 9.53 7 366236 90 79378055
Pulmonary toxicity 12.71 9.53 25 366218 12889 79365256
Hyporesponsive to stimuli 12.68 9.53 29 366214 2059 79376086
Graft versus host disease in skin 12.67 9.53 6 366237 6067 79372078
Injection site warmth 12.65 9.53 31 366212 14776 79363369
Fibromyalgia 12.64 9.53 386 365857 63954 79314191
Malignant catatonia 12.62 9.53 13 366230 452 79377693
Toxic skin eruption 12.60 9.53 56 366187 22237 79355908
Coronary arterial stent insertion 12.57 9.53 6 366237 6038 79372107
Self esteem decreased 12.54 9.53 19 366224 983 79377162
On and off phenomenon 12.51 9.53 38 366205 3202 79374943
Dermatitis exfoliative 12.45 9.53 19 366224 10810 79367335
Perseveration 12.44 9.53 12 366231 385 79377760
Chronic obstructive pulmonary disease 12.42 9.53 495 365748 84924 79293221
Panic disorder 12.41 9.53 36 366207 2956 79375189
Influenza 12.41 9.53 478 365765 129128 79249017
Drug use disorder 12.38 9.53 75 366168 8576 79369569
Vasoconstriction 12.36 9.53 16 366227 714 79377431
Vulvar basal cell carcinoma 12.35 9.53 5 366238 30 79378115
Myalgia 12.32 9.53 712 365531 184929 79193216
Anaemia of malignant disease 12.31 9.53 17 366226 808 79377337
Immunosuppressant drug level increased 12.26 9.53 14 366229 9013 79369132
Foreign body aspiration 12.26 9.53 11 366232 321 79377824
Blood test abnormal 12.25 9.53 41 366202 17669 79360476
Hypotension 12.23 9.53 2248 363995 438069 78940076
Sickle cell anaemia with crisis 12.23 9.53 11 366232 7911 79370234
Vulvovaginal pruritus 12.22 9.53 33 366210 2600 79375545
Delirium tremens 12.22 9.53 16 366227 722 79377423
Induced abortion failed 12.22 9.53 9 366234 197 79377948
Maximal voluntary ventilation abnormal 12.21 9.53 5 366238 31 79378114
Oropharyngeal swelling 12.18 9.53 22 366221 1318 79376827
Pseudophaeochromocytoma 12.15 9.53 7 366236 99 79378046
Panic reaction 12.15 9.53 48 366195 4617 79373528
Middle insomnia 12.14 9.53 120 366123 15949 79362196
Areflexia 12.11 9.53 54 366189 5480 79372665
Hallucination, olfactory 12.09 9.53 13 366230 475 79377670
Suspected suicide attempt 12.09 9.53 11 366232 327 79377818
Electroconvulsive therapy 12.09 9.53 7 366236 100 79378045
Myopathy 12.02 9.53 51 366192 20512 79357633
Impaired work ability 12.01 9.53 48 366195 19633 79358512
Fear of injection 11.99 9.53 10 366233 7464 79370681
Device dislocation 11.97 9.53 70 366173 25900 79352245
Diabetes mellitus inadequate control 11.95 9.53 64 366179 24200 79353945
Polydipsia psychogenic 11.91 9.53 9 366234 205 79377940
Laryngitis 11.89 9.53 36 366207 16003 79362142
Apathy 11.88 9.53 101 366142 12876 79365269
Dry mouth 11.86 9.53 506 365737 87513 79290632
Erectile dysfunction 11.81 9.53 111 366132 14553 79363592
Semen volume decreased 11.80 9.53 6 366237 65 79378080
Post-injection delirium sedation syndrome 11.80 9.53 14 366229 571 79377574
Cerebral haemorrhage 11.76 9.53 190 366053 57483 79320662
Myocarditis 11.75 9.53 152 366091 21581 79356564
Glycosylated haemoglobin increased 11.74 9.53 47 366196 19213 79358932
Intraocular pressure increased 11.73 9.53 15 366228 9190 79368955
Hypotonia 11.69 9.53 100 366143 12770 79365375
Varicella zoster virus infection 11.65 9.53 3 366240 4438 79373707
Product storage error 11.62 9.53 37 366206 16189 79361956
Neonatal hypoxia 11.60 9.53 4 366239 14 79378131
Hypertonic bladder 11.57 9.53 44 366199 4157 79373988
Hepatotoxicity 11.56 9.53 166 366077 51186 79326959
Acute graft versus host disease 11.54 9.53 18 366225 10149 79367996
Nasal polyps 11.52 9.53 10 366233 7317 79370828
Neck mass 11.50 9.53 3 366240 4401 79373744
Substance-induced psychotic disorder 11.48 9.53 38 366205 3351 79374794
Sensitivity to weather change 11.46 9.53 12 366231 8035 79370110
Foot operation 11.46 9.53 6 366237 5727 79372418
Rabbit syndrome 11.42 9.53 11 366232 352 79377793
Blood uric acid increased 11.39 9.53 28 366215 13332 79364813
Foot fracture 11.37 9.53 57 366186 21924 79356221
Increased appetite 11.37 9.53 94 366149 11884 79366261
Injection site haemorrhage 11.37 9.53 78 366165 27792 79350353
Labelled drug-drug interaction issue 11.35 9.53 22 366221 1391 79376754
Klebsiella bacteraemia 11.34 9.53 35 366208 2975 79375170
Thymus disorder 11.29 9.53 10 366233 287 79377858
Porphyria acute 11.25 9.53 23 366220 1512 79376633
Hypertensive crisis 11.25 9.53 53 366190 20717 79357428
Exposure via breast milk 11.23 9.53 18 366225 978 79377167
Drug tolerance decreased 11.23 9.53 27 366216 12951 79365194
Natural killer cell count 11.19 9.53 4 366239 16 79378129
Antidepressant drug level increased 11.13 9.53 12 366231 440 79377705
pH urine increased 11.13 9.53 12 366231 440 79377705
Anion gap increased 11.11 9.53 40 366203 3680 79374465
Adverse event 11.10 9.53 202 366041 60012 79318133
Psychopathic personality 11.10 9.53 3 366240 3 79378142
Thought withdrawal 11.10 9.53 3 366240 3 79378142
Antidepressant drug level below therapeutic 11.10 9.53 3 366240 3 79378142
Purpura 11.07 9.53 49 366194 19478 79358667
Selective mutism 11.06 9.53 6 366237 75 79378070
Atypical femur fracture 11.02 9.53 5 366238 5184 79372961
Vomiting 11.02 9.53 3320 362923 662508 78715637
Amegakaryocytic thrombocytopenia 11.00 9.53 4 366239 17 79378128
Respiratory alkalosis 10.94 9.53 44 366199 4267 79373878
Angina unstable 10.94 9.53 39 366204 16488 79361657
Weight decreased 10.88 9.53 1447 364796 353751 79024394
Septic shock 10.87 9.53 457 365786 122344 79255801
Hyponatriuria 10.82 9.53 4 366239 18 79378127
Hypoprolactinaemia 10.82 9.53 4 366239 18 79378127
Peritonitis bacterial 10.80 9.53 17 366226 9550 79368595
Pneumoconiosis 10.74 9.53 9 366234 239 79377906
Forced expiratory volume decreased 10.74 9.53 12 366231 7802 79370343
Psychiatric symptom 10.72 9.53 62 366181 6973 79371172
Toxicologic test abnormal 10.71 9.53 21 366222 1339 79376806
Cardiac murmur 10.70 9.53 37 366206 15787 79362358
Inappropriate schedule of product administration 10.67 9.53 503 365740 133125 79245020
Hyperuricaemia 10.64 9.53 24 366219 11775 79366370
Psychomotor skills impaired 10.64 9.53 50 366193 5187 79372958
Affective ambivalence 10.64 9.53 4 366239 19 79378126
Abortion spontaneous complete 10.64 9.53 3 366240 4 79378141
Skin disorder 10.63 9.53 102 366141 33841 79344304
Staphylococcal infection 10.61 9.53 196 366047 58099 79320046
Antipsychotic drug level above therapeutic 10.61 9.53 27 366216 2053 79376092
Tangentiality 10.60 9.53 8 366235 182 79377963
Arthropod bite 10.60 9.53 14 366229 8457 79369688
Death of relative 10.56 9.53 9 366234 245 79377900
Hepatic failure 10.47 9.53 208 366035 61004 79317141
C-reactive protein 10.46 9.53 48 366195 4931 79373214
Vulvovaginal burning sensation 10.43 9.53 23 366220 1594 79376551
Ventricular fibrillation 10.40 9.53 95 366148 31831 79346314
Hypogammaglobulinaemia 10.39 9.53 28 366215 12923 79365222
Progressive multifocal leukoencephalopathy 10.33 9.53 54 366189 20546 79357599
Pulmonary arterial hypertension 10.32 9.53 82 366161 28284 79349861
Depressive delusion 10.32 9.53 4 366239 21 79378124
Back pain 10.32 9.53 1231 365012 302949 79075196
Refusal of treatment by relative 10.32 9.53 15 366228 748 79377397
Flight of ideas 10.31 9.53 16 366227 846 79377299
Incorrect dose administered by device 10.30 9.53 5 366238 4984 79373161
Accidental exposure to product 10.29 9.53 93 366150 31229 79346916
Mean cell haemoglobin increased 10.29 9.53 43 366200 4242 79373903
Eye pruritus 10.27 9.53 54 366189 20516 79357629
Pneumonia cytomegaloviral 10.23 9.53 5 366238 4964 79373181
Feeling guilty 10.22 9.53 16 366227 852 79377293
Ultrasound abdomen abnormal 10.22 9.53 7 366236 136 79378009
Sarcoidosis 10.20 9.53 14 366229 8321 79369824
Human herpesvirus 6 infection 10.18 9.53 6 366237 5364 79372781
Diverticulitis 10.16 9.53 149 366094 45787 79332358
Stent placement 10.13 9.53 9 366234 6511 79371634
Underdose 10.11 9.53 211 366032 32940 79345205
Acute respiratory failure 10.09 9.53 351 365892 59190 79318955
Hyponatraemic syndrome 10.06 9.53 15 366228 765 79377380
Food craving 10.05 9.53 23 366220 1634 79376511
Ocular hyperaemia 10.05 9.53 82 366161 28124 79350021
Delusional disorder, unspecified type 10.03 9.53 15 366228 767 79377378
Immunosuppression 10.03 9.53 28 366215 12775 79365370
Purple glove syndrome 10.02 9.53 9 366234 263 79377882
Heart rate increased 10.01 9.53 663 365580 120061 79258084
Hypocalcaemia 10.00 9.53 165 366078 49759 79328386
Hypertension 9.94 9.53 1350 364893 329642 79048503
Retinal detachment 9.91 9.53 17 366226 9230 79368915
Gerstmann's syndrome 9.90 9.53 3 366240 6 79378139
Pleocytosis 9.89 9.53 21 366222 1418 79376727
Morbihan disease 9.88 9.53 4 366239 24 79378121
Duodenal ulcer haemorrhage 9.85 9.53 11 366232 7152 79370993
Phonophobia 9.84 9.53 12 366231 504 79377641
Libido disorder 9.80 9.53 9 366234 271 79377874
False positive investigation result 9.78 9.53 18 366225 1094 79377051
Hyperventilation 9.78 9.53 66 366177 7833 79370312
Atrial tachycardia 9.76 9.53 11 366232 7122 79371023
Type I hypersensitivity 9.72 9.53 4 366239 4394 79373751
Subarachnoid haemorrhage 9.72 9.53 69 366174 24396 79353749
Ureteric obstruction 9.70 9.53 31 366212 2685 79375460
Sexual dysfunction 9.69 9.53 65 366178 7698 79370447
Deja vu 9.69 9.53 5 366238 56 79378089
Bacterial test positive 9.68 9.53 63 366180 7386 79370759
Radiation pneumonitis 9.68 9.53 3 366240 3930 79374215
Lymphoproliferative disorder 9.66 9.53 7 366236 5608 79372537
Slow response to stimuli 9.63 9.53 24 366219 1801 79376344
Cellulitis 9.63 9.53 406 365837 108654 79269491
Skin cancer 9.62 9.53 36 366207 15004 79363141
Squamous cell carcinoma of the oral cavity 9.61 9.53 12 366231 516 79377629
Sleep-related eating disorder 9.60 9.53 14 366229 700 79377445
Obsessive rumination 9.58 9.53 3 366240 7 79378138
Antidepressant drug level decreased 9.58 9.53 3 366240 7 79378138
Torsade de pointes 9.58 9.53 133 366110 19179 79358966
Acute stress disorder 9.58 9.53 11 366232 433 79377712
Normal newborn 9.57 9.53 11 366232 7061 79371084
Adenovirus infection 9.54 9.53 15 366228 8432 79369713

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypotonia neonatal 41.37 25.35 34 466 742 88550
Neonatal asphyxia 30.48 25.35 14 486 97 89195
Nasal congestion 26.02 25.35 9 491 25 89267

Pharmacologic Action:

SourceCodeDescription
ATC N05BA06 NERVOUS SYSTEM
PSYCHOLEPTICS
ANXIOLYTICS
Benzodiazepine derivatives
ATC N05BA56 NERVOUS SYSTEM
PSYCHOLEPTICS
ANXIOLYTICS
Benzodiazepine derivatives
FDA CS M0002356 Benzodiazepines
MeSH PA D014151 Anti-Anxiety Agents
MeSH PA D000927 Anticonvulsants
MeSH PA D000932 Antiemetics
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018682 GABA Agents
MeSH PA D018757 GABA Modulators
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D006993 Hypnotics and Sedatives
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents
FDA EPC N0000175694 Benzodiazepine
CHEBI has role CHEBI:35717 hypnotics

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Myoclonic seizure indication 37356005
Atonic seizure indication 42365007
Anxiety indication 48694002
Absence seizure indication 79631006
Lennox-Gastaut syndrome indication 230418006
Status epilepticus indication 230456007 DOID:1824
Panic disorder indication 371631005 DOID:594
Sedation as Adjunct to Anesthesia indication
Induce Anterograde Amnesia indication
Delirium off-label use 2776000
Alcohol withdrawal delirium off-label use 8635005
General anesthesia off-label use 50697003
Seizure disorder off-label use 128613002
Alcohol withdrawal syndrome off-label use 191480000
Insomnia off-label use 193462001
Spasticity off-label use 221360009
Chemotherapy-induced nausea and vomiting off-label use 236084000
Akathisia off-label use 285145004
Local anesthesia off-label use 386761002
Cocaine-Associated Acute Ischemic Heart Disease off-label use
Manic Bipolar Disorder Adjunct Treatment off-label use
Sedation in Intubated Patients off-label use
Suicidal thoughts contraindication 6471006
Hepatic encephalopathy contraindication 13920009 DOID:13413
Alcohol intoxication contraindication 25702006
Depressive disorder contraindication 35489007
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Substance abuse contraindication 66214007
Sleep apnea contraindication 73430006 DOID:0050847
Decreased respiratory function contraindication 80954004
Open-angle glaucoma contraindication 84494001 DOID:1067
Kidney disease contraindication 90708001 DOID:557
Hypoalbuminemia contraindication 119247004
Liver function tests abnormal contraindication 166603001
Disease of liver contraindication 235856003 DOID:409
Syncope contraindication 271594007
Pregnancy, function contraindication 289908002
Severe chronic obstructive pulmonary disease contraindication 313299006
At risk for aspiration contraindication 371736008
Angle-closure glaucoma contraindication 392291006 DOID:13550
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Central nervous system depression contraindication 418072004
Porphyria contraindication 418470004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.09 acidic
pKa2 11.41 acidic
pKa3 0.63 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
1.5MG LOREEV XR ALMATICA N214826 Feb. 16, 2022 RX CAPSULE, EXTENDED RELEASE ORAL 8999393 Jan. 8, 2034 ONCE DAILY TREATMENT OF ANXIETY DISORDER IN ADULTS
1MG LOREEV XR ALMATICA N214826 Aug. 27, 2021 RX CAPSULE, EXTENDED RELEASE ORAL 8999393 Jan. 8, 2034 ONCE DAILY TREATMENT OF ANXIETY DISORDER IN ADULTS
2MG LOREEV XR ALMATICA N214826 Aug. 27, 2021 RX CAPSULE, EXTENDED RELEASE ORAL 8999393 Jan. 8, 2034 ONCE DAILY TREATMENT OF ANXIETY DISORDER IN ADULTS
3MG LOREEV XR ALMATICA N214826 Aug. 27, 2021 RX CAPSULE, EXTENDED RELEASE ORAL 8999393 Jan. 8, 2034 ONCE DAILY TREATMENT OF ANXIETY DISORDER IN ADULTS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
GABA-A receptor alpha-1/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR IC50 8.46 WOMBAT-PK CHEMBL
Fatty acid-binding protein, liver Unclassified Ki 4.89 CHEMBL

External reference:

IDSource
4017848 VUID
N0000146205 NUI
D00365 KEGG_DRUG
4017848 VANDF
C0024002 UMLSCUI
CHEBI:6539 CHEBI
CHEMBL249262 ChEMBL_ID
CHEMBL580 ChEMBL_ID
CHEMBL399057 ChEMBL_ID
DB00186 DRUGBANK_ID
D008140 MESH_DESCRIPTOR_UI
3958 PUBCHEM_CID
5884 IUPHAR_LIGAND_ID
2809 INN_ID
O26FZP769L UNII
202479 RXNORM
2104 MMSL
3795 MMSL
4995 MMSL
d00149 MMSL
001460 NDDF
19225000 SNOMEDCT_US
387106007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0054-3532 SOLUTION, CONCENTRATE 2 mg ORAL ANDA 19 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0054-3532 SOLUTION, CONCENTRATE 2 mg ORAL ANDA 19 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-3425 TABLET 0.50 mg ORAL ANDA 21 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-3425 TABLET 0.50 mg ORAL ANDA 21 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-3425 TABLET 0.50 mg ORAL ANDA 21 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-3426 TABLET 1 mg ORAL ANDA 21 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-3426 TABLET 1 mg ORAL ANDA 21 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-3426 TABLET 1 mg ORAL ANDA 21 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-3427 TABLET 2 mg ORAL ANDA 21 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-3427 TABLET 2 mg ORAL ANDA 21 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-3427 TABLET 2 mg ORAL ANDA 21 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0121-0770 LIQUID 2 mg ORAL ANDA 21 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0121-0770 LIQUID 2 mg ORAL ANDA 21 sections
Ativan HUMAN PRESCRIPTION DRUG LABEL 1 0187-0063 TABLET 0.50 mg ORAL NDA 20 sections
Ativan HUMAN PRESCRIPTION DRUG LABEL 1 0187-0063 TABLET 0.50 mg ORAL NDA 20 sections
Ativan HUMAN PRESCRIPTION DRUG LABEL 1 0187-0064 TABLET 1 mg ORAL NDA 20 sections
Ativan HUMAN PRESCRIPTION DRUG LABEL 1 0187-0064 TABLET 1 mg ORAL NDA 20 sections
Ativan HUMAN PRESCRIPTION DRUG LABEL 1 0187-0065 TABLET 2 mg ORAL NDA 20 sections
Ativan HUMAN PRESCRIPTION DRUG LABEL 1 0187-0065 TABLET 2 mg ORAL NDA 20 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0409-1539 INJECTION, SOLUTION 4 mg INTRAMUSCULAR ANDA 34 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0409-1539 INJECTION, SOLUTION 4 mg INTRAMUSCULAR ANDA 34 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0409-1539 INJECTION, SOLUTION 4 mg INTRAMUSCULAR ANDA 34 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0409-1985 INJECTION, SOLUTION 2 mg INTRAMUSCULAR ANDA 34 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0409-1985 INJECTION, SOLUTION 2 mg INTRAMUSCULAR ANDA 34 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0409-1985 INJECTION, SOLUTION 2 mg INTRAMUSCULAR ANDA 34 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0409-6778 INJECTION, SOLUTION 2 mg INTRAMUSCULAR ANDA 33 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0409-6778 INJECTION, SOLUTION 2 mg INTRAMUSCULAR ANDA 33 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0409-6778 INJECTION, SOLUTION 2 mg INTRAMUSCULAR ANDA 33 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0409-6778 INJECTION, SOLUTION 2 mg INTRAMUSCULAR ANDA 33 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0409-6778 INJECTION, SOLUTION 2 mg INTRAMUSCULAR ANDA 33 sections