Stem definition | Drug id | CAS RN |
---|---|---|
diazepam derivatives | 1606 | 846-49-1 |
Dose | Unit | Route |
---|---|---|
2.50 | mg | O |
2.50 | mg | P |
2.50 | mg | SL |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.08 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.44 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 93 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 1.30 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 1 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.09 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 17 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Sept. 30, 1977 | FDA | VALEANT INTL |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Sopor | 1829.87 | 9.61 | 1161 | 243557 | 18718 | 50341688 |
Drug abuse | 1195.02 | 9.61 | 1460 | 243258 | 58386 | 50302020 |
Completed suicide | 560.16 | 9.61 | 1652 | 243066 | 130237 | 50230169 |
Suicide attempt | 495.59 | 9.61 | 894 | 243824 | 50838 | 50309568 |
Intentional self-injury | 403.94 | 9.61 | 528 | 244190 | 22584 | 50337822 |
Somnolence | 402.45 | 9.61 | 1649 | 243069 | 153336 | 50207070 |
Neuroleptic malignant syndrome | 378.16 | 9.61 | 360 | 244358 | 10770 | 50349636 |
Intentional overdose | 369.79 | 9.61 | 886 | 243832 | 61618 | 50298788 |
Overdose | 362.70 | 9.61 | 1184 | 243534 | 98543 | 50261863 |
Bradyphrenia | 355.38 | 9.61 | 270 | 244448 | 5882 | 50354524 |
Agitation | 342.29 | 9.61 | 781 | 243937 | 52603 | 50307803 |
Contraindicated product administered | 334.07 | 9.61 | 151 | 244567 | 148807 | 50211599 |
Pemphigus | 318.18 | 9.61 | 93 | 244625 | 120073 | 50240333 |
Coma | 315.93 | 9.61 | 787 | 243931 | 56092 | 50304314 |
Drug ineffective | 309.31 | 9.61 | 2513 | 242205 | 816820 | 49543586 |
Systemic lupus erythematosus | 303.88 | 9.61 | 150 | 244568 | 140472 | 50219934 |
Drug intolerance | 272.75 | 9.61 | 398 | 244320 | 218706 | 50141700 |
Delirium | 258.49 | 9.61 | 571 | 244147 | 37621 | 50322785 |
Arthropathy | 246.39 | 9.61 | 240 | 244478 | 157666 | 50202740 |
Treatment failure | 237.86 | 9.61 | 190 | 244528 | 137447 | 50222959 |
Joint swelling | 234.96 | 9.61 | 524 | 244194 | 244762 | 50115644 |
Alopecia | 234.31 | 9.61 | 524 | 244194 | 244523 | 50115883 |
Catatonia | 233.70 | 9.61 | 172 | 244546 | 3564 | 50356842 |
Toxicity to various agents | 230.55 | 9.61 | 1787 | 242931 | 210712 | 50149694 |
Hand deformity | 228.63 | 9.61 | 99 | 244619 | 100100 | 50260306 |
Rheumatoid arthritis | 224.66 | 9.61 | 397 | 244321 | 202153 | 50158253 |
Glossodynia | 214.57 | 9.61 | 148 | 244570 | 115421 | 50244985 |
Drug withdrawal syndrome | 209.62 | 9.61 | 409 | 244309 | 24672 | 50335734 |
Therapeutic product effect decreased | 196.21 | 9.61 | 221 | 244497 | 135829 | 50224577 |
Swelling | 193.20 | 9.61 | 428 | 244290 | 200444 | 50159962 |
Serotonin syndrome | 175.77 | 9.61 | 377 | 244341 | 24336 | 50336070 |
Anti-cyclic citrullinated peptide antibody positive | 175.46 | 9.61 | 61 | 244657 | 70526 | 50289880 |
Drug interaction | 171.58 | 9.61 | 1594 | 243124 | 198027 | 50162379 |
Poisoning | 170.82 | 9.61 | 253 | 244465 | 12176 | 50348230 |
Hypersensitivity | 168.13 | 9.61 | 509 | 244209 | 214652 | 50145754 |
Arthralgia | 168.01 | 9.61 | 1338 | 243380 | 437364 | 49923042 |
Abdominal discomfort | 167.74 | 9.61 | 567 | 244151 | 231074 | 50129332 |
Suicidal ideation | 165.97 | 9.61 | 617 | 244101 | 54768 | 50305638 |
Anxiety | 165.81 | 9.61 | 1444 | 243274 | 176162 | 50184244 |
Mydriasis | 161.66 | 9.61 | 227 | 244491 | 10400 | 50350006 |
Tachycardia | 160.61 | 9.61 | 926 | 243792 | 98837 | 50261569 |
Psychotic disorder | 160.04 | 9.61 | 337 | 244381 | 21475 | 50338931 |
Disorientation | 154.64 | 9.61 | 449 | 244269 | 35035 | 50325371 |
Synovitis | 152.02 | 9.61 | 227 | 244491 | 123638 | 50236768 |
Mania | 149.73 | 9.61 | 222 | 244496 | 10694 | 50349712 |
Maternal exposure during pregnancy | 149.06 | 9.61 | 346 | 244372 | 159432 | 50200974 |
Drug dependence | 146.97 | 9.61 | 307 | 244411 | 19452 | 50340954 |
Pneumonia aspiration | 146.53 | 9.61 | 404 | 244314 | 30600 | 50329806 |
Confusional state | 144.63 | 9.61 | 1454 | 243264 | 184474 | 50175932 |
Restlessness | 140.42 | 9.61 | 349 | 244369 | 24824 | 50335582 |
Bradykinesia | 138.63 | 9.61 | 130 | 244588 | 3813 | 50356593 |
Pain | 137.93 | 9.61 | 1972 | 242746 | 576931 | 49783475 |
Infusion related reaction | 137.56 | 9.61 | 394 | 244324 | 169163 | 50191243 |
Rash | 134.50 | 9.61 | 1410 | 243308 | 436061 | 49924345 |
Depressed level of consciousness | 131.57 | 9.61 | 549 | 244169 | 51404 | 50309002 |
Rheumatoid factor positive | 127.55 | 9.61 | 41 | 244677 | 49818 | 50310588 |
Respiratory depression | 124.53 | 9.61 | 215 | 244503 | 11795 | 50348611 |
Wound | 118.40 | 9.61 | 206 | 244512 | 105588 | 50254818 |
Pericarditis | 108.90 | 9.61 | 132 | 244586 | 78557 | 50281849 |
Akathisia | 108.07 | 9.61 | 164 | 244554 | 8065 | 50352341 |
Mobility decreased | 106.58 | 9.61 | 138 | 244580 | 79810 | 50280596 |
Hepatic enzyme increased | 106.50 | 9.61 | 326 | 244392 | 137054 | 50223352 |
Drug hypersensitivity | 102.70 | 9.61 | 751 | 243967 | 250259 | 50110147 |
Speech disorder | 97.43 | 9.61 | 385 | 244333 | 35163 | 50325243 |
Muscle rigidity | 96.77 | 9.61 | 172 | 244546 | 9657 | 50350749 |
Lower respiratory tract infection | 96.30 | 9.61 | 197 | 244521 | 95004 | 50265402 |
Psychomotor hyperactivity | 95.77 | 9.61 | 166 | 244552 | 9135 | 50351271 |
Discomfort | 95.26 | 9.61 | 242 | 244476 | 108138 | 50252268 |
Slow speech | 93.95 | 9.61 | 65 | 244653 | 1217 | 50359189 |
Hypothermia | 93.24 | 9.61 | 190 | 244528 | 11826 | 50348580 |
Mental status changes | 93.16 | 9.61 | 385 | 244333 | 35887 | 50324519 |
Product use issue | 90.58 | 9.61 | 393 | 244325 | 149082 | 50211324 |
Dysarthria | 89.85 | 9.61 | 389 | 244329 | 37014 | 50323392 |
Extrapyramidal disorder | 88.84 | 9.61 | 184 | 244534 | 11586 | 50348820 |
Withdrawal syndrome | 86.89 | 9.61 | 233 | 244485 | 17357 | 50343049 |
Blister | 86.18 | 9.61 | 177 | 244541 | 85241 | 50275165 |
Abnormal behaviour | 85.88 | 9.61 | 249 | 244469 | 19409 | 50340997 |
Schizophrenia | 84.11 | 9.61 | 138 | 244580 | 7259 | 50353147 |
Delusion | 83.06 | 9.61 | 168 | 244550 | 10401 | 50350005 |
Tremor | 82.79 | 9.61 | 885 | 243833 | 114018 | 50246388 |
Off label use | 82.66 | 9.61 | 1709 | 243009 | 472717 | 49887689 |
Tardive dyskinesia | 81.69 | 9.61 | 135 | 244583 | 7144 | 50353262 |
Sinusitis | 80.39 | 9.61 | 489 | 244229 | 170069 | 50190337 |
Injection site pain | 78.72 | 9.61 | 274 | 244444 | 110750 | 50249656 |
Sedation | 77.90 | 9.61 | 324 | 244394 | 30286 | 50330120 |
Aggression | 77.80 | 9.61 | 252 | 244466 | 20864 | 50339542 |
Bezoar | 77.49 | 9.61 | 59 | 244659 | 1289 | 50359117 |
Gastric pH decreased | 77.14 | 9.61 | 45 | 244673 | 617 | 50359789 |
Device expulsion | 76.79 | 9.61 | 22 | 244696 | 28800 | 50331606 |
Seizure | 76.32 | 9.61 | 889 | 243829 | 116985 | 50243421 |
Depression | 74.31 | 9.61 | 1168 | 243550 | 164255 | 50196151 |
Derealisation | 74.23 | 9.61 | 52 | 244666 | 994 | 50359412 |
Hyponatraemia | 73.75 | 9.61 | 750 | 243968 | 95389 | 50265017 |
Respiratory arrest | 72.00 | 9.61 | 312 | 244406 | 29697 | 50330709 |
Incontinence | 71.76 | 9.61 | 153 | 244565 | 9832 | 50350574 |
Pneumonia viral | 70.40 | 9.61 | 122 | 244596 | 6712 | 50353694 |
Hallucination | 69.82 | 9.61 | 425 | 244293 | 46232 | 50314174 |
Hallucination, auditory | 68.75 | 9.61 | 157 | 244561 | 10571 | 50349835 |
Drooling | 66.53 | 9.61 | 82 | 244636 | 3302 | 50357104 |
Infection | 66.16 | 9.61 | 527 | 244191 | 172427 | 50187979 |
Psychomotor retardation | 65.87 | 9.61 | 82 | 244636 | 3336 | 50357070 |
Unresponsive to stimuli | 65.76 | 9.61 | 308 | 244410 | 30301 | 50330105 |
Soft tissue disorder | 65.56 | 9.61 | 91 | 244627 | 4123 | 50356283 |
Nasopharyngitis | 64.84 | 9.61 | 608 | 244110 | 192319 | 50168087 |
Injection site erythema | 63.78 | 9.61 | 170 | 244548 | 74766 | 50285640 |
Peripheral swelling | 62.95 | 9.61 | 664 | 244054 | 205272 | 50155134 |
Dehydration | 62.73 | 9.61 | 1061 | 243657 | 151388 | 50209018 |
Knee arthroplasty | 62.47 | 9.61 | 49 | 244669 | 35797 | 50324609 |
Cardiac arrest | 62.44 | 9.61 | 649 | 244069 | 83002 | 50277404 |
Substance abuse | 61.11 | 9.61 | 87 | 244631 | 4037 | 50356369 |
Salivary hypersecretion | 60.64 | 9.61 | 112 | 244606 | 6479 | 50353927 |
Cogwheel rigidity | 59.45 | 9.61 | 57 | 244661 | 1720 | 50358686 |
Dissociation | 59.33 | 9.61 | 64 | 244654 | 2227 | 50358179 |
Feeling of despair | 58.74 | 9.61 | 60 | 244658 | 1958 | 50358448 |
Electrocardiogram QT prolonged | 58.69 | 9.61 | 441 | 244277 | 51445 | 50308961 |
Hip arthroplasty | 57.73 | 9.61 | 38 | 244680 | 30391 | 50330015 |
Electrocardiogram QRS complex prolonged | 57.15 | 9.61 | 97 | 244621 | 5247 | 50355159 |
Dystonia | 56.93 | 9.61 | 156 | 244562 | 11770 | 50348636 |
Psoriatic arthropathy | 54.04 | 9.61 | 90 | 244628 | 46942 | 50313464 |
Therapeutic product effect incomplete | 53.96 | 9.61 | 243 | 244475 | 91272 | 50269134 |
Stupor | 53.70 | 9.61 | 76 | 244642 | 3507 | 50356899 |
Hypokinesia | 53.60 | 9.61 | 155 | 244563 | 12062 | 50348344 |
Status epilepticus | 53.06 | 9.61 | 164 | 244554 | 13242 | 50347164 |
Hallucinations, mixed | 52.79 | 9.61 | 81 | 244637 | 4022 | 50356384 |
Pruritus | 52.70 | 9.61 | 1010 | 243708 | 282558 | 50077848 |
Febrile neutropenia | 52.67 | 9.61 | 712 | 244006 | 96955 | 50263451 |
Mental disorder | 51.50 | 9.61 | 227 | 244491 | 21764 | 50338642 |
Mutism | 51.39 | 9.61 | 47 | 244671 | 1334 | 50359072 |
Depersonalisation/derealisation disorder | 51.01 | 9.61 | 44 | 244674 | 1154 | 50359252 |
Alcohol interaction | 50.52 | 9.61 | 57 | 244661 | 2087 | 50358319 |
Loss of consciousness | 50.36 | 9.61 | 746 | 243972 | 103607 | 50256799 |
Therapeutic response decreased | 50.10 | 9.61 | 95 | 244623 | 47136 | 50313270 |
Paranoia | 50.03 | 9.61 | 136 | 244582 | 10212 | 50350194 |
Impaired healing | 49.60 | 9.61 | 172 | 244546 | 69614 | 50290792 |
Duodenal ulcer perforation | 49.04 | 9.61 | 91 | 244627 | 45520 | 50314886 |
Dyskinesia | 49.03 | 9.61 | 265 | 244453 | 27596 | 50332810 |
Sinus tachycardia | 47.44 | 9.61 | 217 | 244501 | 21137 | 50339269 |
Narcotic bowel syndrome | 46.39 | 9.61 | 19 | 244699 | 111 | 50360295 |
Psoriasis | 45.78 | 9.61 | 175 | 244543 | 68825 | 50291581 |
H1N1 influenza | 45.61 | 9.61 | 47 | 244671 | 1550 | 50358856 |
Fall | 44.84 | 9.61 | 2014 | 242704 | 332918 | 50027488 |
Mood swings | 44.68 | 9.61 | 174 | 244544 | 15780 | 50344626 |
Folliculitis | 44.20 | 9.61 | 76 | 244642 | 39149 | 50321257 |
Cardio-respiratory arrest | 44.01 | 9.61 | 426 | 244292 | 53466 | 50306940 |
Miosis | 43.41 | 9.61 | 95 | 244623 | 6215 | 50354191 |
Red blood cell sedimentation rate increased | 43.22 | 9.61 | 47 | 244671 | 29369 | 50331037 |
Injection site reaction | 42.95 | 9.61 | 113 | 244605 | 49919 | 50310487 |
Rheumatic fever | 42.90 | 9.61 | 14 | 244704 | 16853 | 50343553 |
Interstitial lung disease | 42.74 | 9.61 | 124 | 244594 | 53052 | 50307354 |
Sleep disorder due to general medical condition, insomnia type | 42.18 | 9.61 | 54 | 244664 | 31393 | 50329013 |
Tachypnoea | 41.66 | 9.61 | 160 | 244558 | 14417 | 50345989 |
Parosmia | 41.59 | 9.61 | 76 | 244642 | 4360 | 50356046 |
Somatic symptom disorder | 41.30 | 9.61 | 49 | 244669 | 1895 | 50358511 |
COVID-19 | 41.12 | 9.61 | 104 | 244614 | 46558 | 50313848 |
Persecutory delusion | 40.86 | 9.61 | 54 | 244664 | 2333 | 50358073 |
Injection site pruritus | 40.52 | 9.61 | 84 | 244634 | 40327 | 50320079 |
Ill-defined disorder | 40.00 | 9.61 | 133 | 244585 | 54521 | 50305885 |
Condition aggravated | 40.00 | 9.61 | 1112 | 243606 | 295946 | 50064460 |
Muscle injury | 39.93 | 9.61 | 74 | 244644 | 37037 | 50323369 |
Diabetes insipidus | 39.73 | 9.61 | 53 | 244665 | 2311 | 50358095 |
Urinary retention | 39.45 | 9.61 | 239 | 244479 | 25951 | 50334455 |
Bone erosion | 39.40 | 9.61 | 5 | 244713 | 11682 | 50348724 |
Musculoskeletal stiffness | 39.33 | 9.61 | 414 | 244304 | 128067 | 50232339 |
Helicobacter infection | 39.15 | 9.61 | 117 | 244601 | 49585 | 50310821 |
Brain injury | 38.52 | 9.61 | 88 | 244630 | 5926 | 50354480 |
Pain in extremity | 38.40 | 9.61 | 1015 | 243703 | 271850 | 50088556 |
Respiratory failure | 38.35 | 9.61 | 637 | 244081 | 90544 | 50269862 |
Hypoxia | 38.31 | 9.61 | 397 | 244321 | 50726 | 50309680 |
Myocardial depression | 38.21 | 9.61 | 25 | 244693 | 425 | 50359981 |
Constipation | 37.44 | 9.61 | 1169 | 243549 | 184539 | 50175867 |
Product dose omission issue | 37.18 | 9.61 | 645 | 244073 | 183193 | 50177213 |
C-reactive protein abnormal | 37.05 | 9.61 | 48 | 244670 | 27761 | 50332645 |
Coma scale abnormal | 36.49 | 9.61 | 75 | 244643 | 4696 | 50355710 |
Crying | 36.47 | 9.61 | 195 | 244523 | 20221 | 50340185 |
Irritable bowel syndrome | 36.41 | 9.61 | 127 | 244591 | 51314 | 50309092 |
Decorticate posture | 36.38 | 9.61 | 21 | 244697 | 282 | 50360124 |
Small intestinal obstruction | 36.22 | 9.61 | 164 | 244554 | 15904 | 50344502 |
Nightmare | 36.13 | 9.61 | 164 | 244554 | 15922 | 50344484 |
Insomnia | 36.11 | 9.61 | 1104 | 243614 | 173761 | 50186645 |
C-reactive protein increased | 35.97 | 9.61 | 182 | 244536 | 66292 | 50294114 |
Myoclonus | 35.90 | 9.61 | 152 | 244566 | 14318 | 50346088 |
Skin necrosis | 35.79 | 9.61 | 5 | 244713 | 10862 | 50349544 |
Alcohol abuse | 35.67 | 9.61 | 45 | 244673 | 1856 | 50358550 |
Disorganised speech | 35.47 | 9.61 | 33 | 244685 | 958 | 50359448 |
Injection site swelling | 35.36 | 9.61 | 95 | 244623 | 41678 | 50318728 |
Abortion spontaneous | 35.36 | 9.61 | 95 | 244623 | 41677 | 50318729 |
Encephalopathy | 35.05 | 9.61 | 281 | 244437 | 33430 | 50326976 |
Hallucination, visual | 34.99 | 9.61 | 166 | 244552 | 16416 | 50343990 |
Victim of sexual abuse | 34.89 | 9.61 | 25 | 244693 | 496 | 50359910 |
Cytomegalovirus infection | 34.66 | 9.61 | 22 | 244696 | 17940 | 50342466 |
Panic attack | 34.05 | 9.61 | 184 | 244534 | 19158 | 50341248 |
Multiple-drug resistance | 33.93 | 9.61 | 59 | 244659 | 3255 | 50357151 |
Headache | 33.77 | 9.61 | 2056 | 242662 | 504479 | 49855927 |
Swollen joint count increased | 33.42 | 9.61 | 15 | 244703 | 14858 | 50345548 |
Drug use disorder | 33.17 | 9.61 | 56 | 244662 | 3016 | 50357390 |
Toxic epidermal necrolysis | 32.58 | 9.61 | 32 | 244686 | 20960 | 50339446 |
Inflammation | 32.42 | 9.61 | 153 | 244565 | 56759 | 50303647 |
Dysphagia | 32.39 | 9.61 | 541 | 244177 | 76977 | 50283429 |
Nicotine dependence | 31.90 | 9.61 | 26 | 244692 | 629 | 50359777 |
Exposure during pregnancy | 31.57 | 9.61 | 404 | 244314 | 120611 | 50239795 |
Blood prolactin increased | 31.50 | 9.61 | 55 | 244663 | 3044 | 50357362 |
Feeling jittery | 31.48 | 9.61 | 122 | 244596 | 11038 | 50349368 |
Emotional disorder | 31.46 | 9.61 | 127 | 244591 | 11709 | 50348697 |
Disturbance in attention | 30.83 | 9.61 | 257 | 244461 | 30929 | 50329477 |
Erythema | 30.79 | 9.61 | 510 | 244208 | 145904 | 50214502 |
Pallor | 30.79 | 9.61 | 205 | 244513 | 22994 | 50337412 |
Cerebral microhaemorrhage | 30.78 | 9.61 | 13 | 244705 | 83 | 50360323 |
Anaphylactic shock | 29.83 | 9.61 | 32 | 244686 | 20123 | 50340283 |
Computerised tomogram thorax abnormal | 29.62 | 9.61 | 35 | 244683 | 1348 | 50359058 |
Oral pain | 29.57 | 9.61 | 215 | 244503 | 24818 | 50335588 |
Parkinsonism | 29.41 | 9.61 | 102 | 244616 | 8745 | 50351661 |
Hyperammonaemic encephalopathy | 29.37 | 9.61 | 42 | 244676 | 1957 | 50358449 |
Hyperhidrosis | 29.31 | 9.61 | 601 | 244117 | 88825 | 50271581 |
Pulseless electrical activity | 29.25 | 9.61 | 86 | 244632 | 6755 | 50353651 |
Aspiration | 29.24 | 9.61 | 105 | 244613 | 9159 | 50351247 |
Feeling of body temperature change | 29.20 | 9.61 | 65 | 244653 | 4302 | 50356104 |
Drug eruption | 29.18 | 9.61 | 43 | 244675 | 23563 | 50336843 |
Lethargy | 28.99 | 9.61 | 366 | 244352 | 49066 | 50311340 |
Psychiatric decompensation | 28.89 | 9.61 | 33 | 244685 | 1225 | 50359181 |
Intentional product misuse | 28.69 | 9.61 | 349 | 244369 | 46385 | 50314021 |
Accidental exposure to product by child | 28.61 | 9.61 | 30 | 244688 | 1010 | 50359396 |
Restless legs syndrome | 28.51 | 9.61 | 152 | 244566 | 15745 | 50344661 |
Loss of personal independence in daily activities | 28.37 | 9.61 | 210 | 244508 | 69840 | 50290566 |
Blood pH decreased | 28.18 | 9.61 | 46 | 244672 | 2409 | 50357997 |
Injection site bruising | 27.93 | 9.61 | 88 | 244630 | 36680 | 50323726 |
Apnoea | 27.36 | 9.61 | 85 | 244633 | 6881 | 50353525 |
Pancreatic fibrosis | 27.25 | 9.61 | 12 | 244706 | 86 | 50360320 |
Skin ulcer | 27.20 | 9.61 | 84 | 244634 | 35234 | 50325172 |
Adverse event | 27.13 | 9.61 | 114 | 244604 | 43649 | 50316757 |
Respiratory acidosis | 26.95 | 9.61 | 77 | 244641 | 5951 | 50354455 |
Plasma cell myeloma | 26.76 | 9.61 | 250 | 244468 | 31072 | 50329334 |
Electroencephalogram abnormal | 26.76 | 9.61 | 55 | 244663 | 3444 | 50356962 |
Live birth | 26.65 | 9.61 | 24 | 244694 | 16384 | 50344022 |
Mouth ulceration | 26.65 | 9.61 | 60 | 244658 | 27964 | 50332442 |
Granulocytopenia | 26.55 | 9.61 | 70 | 244648 | 5161 | 50355245 |
Hyperreflexia | 26.50 | 9.61 | 69 | 244649 | 5049 | 50355357 |
Mental impairment | 26.46 | 9.61 | 122 | 244596 | 11922 | 50348484 |
Red blood cell sedimentation rate abnormal | 26.44 | 9.61 | 24 | 244694 | 16319 | 50344087 |
Renal ischaemia | 26.05 | 9.61 | 22 | 244696 | 560 | 50359846 |
Macrocytosis | 25.94 | 9.61 | 41 | 244677 | 2089 | 50358317 |
Hepatic function abnormal | 25.69 | 9.61 | 77 | 244641 | 32604 | 50327802 |
Aphasia | 25.65 | 9.61 | 230 | 244488 | 28264 | 50332142 |
Basal cell carcinoma | 25.64 | 9.61 | 46 | 244672 | 23310 | 50337096 |
Morbid thoughts | 25.32 | 9.61 | 21 | 244697 | 521 | 50359885 |
Accidental overdose | 24.96 | 9.61 | 171 | 244547 | 19362 | 50341044 |
Hypotension | 24.83 | 9.61 | 1384 | 243334 | 234085 | 50126321 |
Hypochloraemia | 24.78 | 9.61 | 35 | 244683 | 1612 | 50358794 |
Acute psychosis | 24.68 | 9.61 | 41 | 244677 | 2179 | 50358227 |
PCO2 increased | 24.60 | 9.61 | 29 | 244689 | 1114 | 50359292 |
Coma scale | 24.53 | 9.61 | 9 | 244709 | 37 | 50360369 |
Mitochondrial encephalomyopathy | 24.49 | 9.61 | 8 | 244710 | 21 | 50360385 |
Atelectasis | 23.98 | 9.61 | 161 | 244557 | 18109 | 50342297 |
Encephalitis autoimmune | 23.95 | 9.61 | 30 | 244688 | 1228 | 50359178 |
Intentional product use issue | 23.87 | 9.61 | 247 | 244471 | 76671 | 50283735 |
Urticaria | 23.24 | 9.61 | 464 | 244254 | 129097 | 50231309 |
Bradypnoea | 23.13 | 9.61 | 48 | 244670 | 3026 | 50357380 |
PO2 increased | 23.13 | 9.61 | 24 | 244694 | 798 | 50359608 |
Hypertonia | 23.12 | 9.61 | 56 | 244662 | 3917 | 50356489 |
Cataract | 23.10 | 9.61 | 134 | 244584 | 47166 | 50313240 |
Haematotoxicity | 23.02 | 9.61 | 5 | 244713 | 7890 | 50352516 |
Homicide | 22.98 | 9.61 | 17 | 244701 | 355 | 50360051 |
Respiratory distress | 22.95 | 9.61 | 237 | 244481 | 30252 | 50330154 |
Myelosuppression | 22.90 | 9.61 | 19 | 244699 | 13498 | 50346908 |
Echolalia | 22.82 | 9.61 | 13 | 244705 | 170 | 50360236 |
Mood altered | 22.81 | 9.61 | 122 | 244596 | 12651 | 50347755 |
Foot deformity | 22.78 | 9.61 | 36 | 244682 | 19174 | 50341232 |
Neurosensory hypoacusis | 22.74 | 9.61 | 14 | 244704 | 213 | 50360193 |
Menstrual disorder | 22.71 | 9.61 | 59 | 244659 | 4311 | 50356095 |
Schizophreniform disorder | 22.67 | 9.61 | 10 | 244708 | 72 | 50360334 |
Obsessive-compulsive disorder | 22.65 | 9.61 | 50 | 244668 | 3290 | 50357116 |
Gastrointestinal disorder | 22.58 | 9.61 | 321 | 244397 | 94135 | 50266271 |
Generalised tonic-clonic seizure | 22.48 | 9.61 | 210 | 244508 | 26100 | 50334306 |
Withdrawal catatonia | 22.35 | 9.61 | 9 | 244709 | 50 | 50360356 |
Malaise | 22.11 | 9.61 | 1363 | 243355 | 334169 | 50026237 |
Hypophagia | 22.05 | 9.61 | 218 | 244500 | 27510 | 50332896 |
Pneumocystis jirovecii pneumonia | 22.02 | 9.61 | 23 | 244695 | 14640 | 50345766 |
Osteoporosis | 21.99 | 9.61 | 127 | 244591 | 44752 | 50315654 |
Poisoning deliberate | 21.92 | 9.61 | 86 | 244632 | 7826 | 50352580 |
Renal impairment | 21.86 | 9.61 | 247 | 244471 | 75414 | 50284992 |
Screaming | 21.83 | 9.61 | 46 | 244672 | 2932 | 50357474 |
Blood creatine phosphokinase increased | 21.80 | 9.61 | 209 | 244509 | 26158 | 50334248 |
Bradycardia | 21.78 | 9.61 | 435 | 244283 | 63991 | 50296415 |
Femur fracture | 21.76 | 9.61 | 100 | 244618 | 37364 | 50323042 |
Bipolar disorder | 21.68 | 9.61 | 77 | 244641 | 6680 | 50353726 |
Antipsychotic drug level increased | 21.61 | 9.61 | 47 | 244671 | 3062 | 50357344 |
Communication disorder | 21.53 | 9.61 | 39 | 244679 | 2222 | 50358184 |
Ataxia | 21.52 | 9.61 | 127 | 244591 | 13659 | 50346747 |
Patient uncooperative | 21.39 | 9.61 | 12 | 244706 | 152 | 50360254 |
Behaviour disorder | 21.34 | 9.61 | 40 | 244678 | 2340 | 50358066 |
Ear infection | 21.28 | 9.61 | 60 | 244658 | 25910 | 50334496 |
Change of bowel habit | 21.26 | 9.61 | 34 | 244684 | 1750 | 50358656 |
Wrong patient received product | 21.09 | 9.61 | 33 | 244685 | 1667 | 50358739 |
Homicidal ideation | 21.06 | 9.61 | 33 | 244685 | 1669 | 50358737 |
Ventricular hypokinesia | 20.96 | 9.61 | 54 | 244664 | 3926 | 50356480 |
Asthenia | 20.94 | 9.61 | 1803 | 242915 | 317239 | 50043167 |
Failure to thrive | 20.87 | 9.61 | 73 | 244645 | 6285 | 50354121 |
Muscle disorder | 20.86 | 9.61 | 57 | 244661 | 4293 | 50356113 |
Emotional distress | 20.72 | 9.61 | 221 | 244497 | 28442 | 50331964 |
Leukocytosis | 20.70 | 9.61 | 183 | 244535 | 22396 | 50338010 |
Myocardial fibrosis | 20.61 | 9.61 | 21 | 244697 | 683 | 50359723 |
Grip strength decreased | 20.58 | 9.61 | 17 | 244701 | 12104 | 50348302 |
Skin maceration | 20.55 | 9.61 | 8 | 244710 | 40 | 50360366 |
Tremor neonatal | 20.49 | 9.61 | 10 | 244708 | 93 | 50360313 |
Wrong drug | 20.35 | 9.61 | 11 | 244707 | 129 | 50360277 |
Neutropenic sepsis | 20.35 | 9.61 | 23 | 244695 | 14124 | 50346282 |
Tenosynovitis | 20.30 | 9.61 | 13 | 244705 | 10552 | 50349854 |
Osteoarthritis | 20.20 | 9.61 | 223 | 244495 | 68383 | 50292023 |
Psychomotor skills impaired | 20.16 | 9.61 | 36 | 244682 | 2028 | 50358378 |
Vomiting | 20.16 | 9.61 | 2533 | 242185 | 458225 | 49902181 |
Sacroiliitis | 20.07 | 9.61 | 41 | 244677 | 2556 | 50357850 |
Major depression | 20.03 | 9.61 | 76 | 244642 | 6808 | 50353598 |
Sputum purulent | 20.01 | 9.61 | 24 | 244694 | 939 | 50359467 |
Blood bicarbonate decreased | 19.86 | 9.61 | 42 | 244676 | 2683 | 50357723 |
Alcohol use | 19.75 | 9.61 | 35 | 244683 | 1960 | 50358446 |
Mean cell haemoglobin increased | 19.52 | 9.61 | 37 | 244681 | 2183 | 50358223 |
Solar urticaria | 19.36 | 9.61 | 8 | 244710 | 48 | 50360358 |
Refusal of treatment by patient | 19.24 | 9.61 | 61 | 244657 | 4992 | 50355414 |
Protein C increased | 19.13 | 9.61 | 10 | 244708 | 109 | 50360297 |
Haemophagocytic lymphohistiocytosis | 18.94 | 9.61 | 9 | 244709 | 8624 | 50351782 |
Pulmonary embolism | 18.86 | 9.61 | 634 | 244084 | 101070 | 50259336 |
Death | 18.80 | 9.61 | 1822 | 242896 | 323557 | 50036849 |
Device issue | 18.79 | 9.61 | 43 | 244675 | 19929 | 50340477 |
Depressed mood | 18.72 | 9.61 | 249 | 244469 | 33774 | 50326632 |
Muscle spasticity | 18.72 | 9.61 | 34 | 244684 | 17150 | 50343256 |
Panniculitis | 18.45 | 9.61 | 9 | 244709 | 8494 | 50351912 |
Alcohol poisoning | 18.37 | 9.61 | 32 | 244686 | 1768 | 50358638 |
Urinary incontinence | 18.34 | 9.61 | 213 | 244505 | 27995 | 50332411 |
Affective disorder | 18.34 | 9.61 | 61 | 244657 | 5120 | 50355286 |
Rapid eye movements sleep abnormal | 18.30 | 9.61 | 10 | 244708 | 120 | 50360286 |
Alcoholism | 18.12 | 9.61 | 30 | 244688 | 1590 | 50358816 |
Joint injury | 18.10 | 9.61 | 50 | 244668 | 21739 | 50338667 |
Abdominal pain | 18.08 | 9.61 | 1351 | 243367 | 234877 | 50125529 |
Galactorrhoea | 18.07 | 9.61 | 49 | 244669 | 3674 | 50356732 |
Drop attacks | 18.04 | 9.61 | 19 | 244699 | 643 | 50359763 |
Rhesus antigen positive | 18.01 | 9.61 | 10 | 244708 | 124 | 50360282 |
Persistent left superior vena cava | 17.98 | 9.61 | 7 | 244711 | 35 | 50360371 |
Device difficult to use | 17.88 | 9.61 | 13 | 244705 | 9873 | 50350533 |
Phagophobia | 17.82 | 9.61 | 7 | 244711 | 36 | 50360370 |
Thymus disorder | 17.75 | 9.61 | 12 | 244706 | 216 | 50360190 |
Hypotonia | 17.58 | 9.61 | 82 | 244636 | 8052 | 50352354 |
Metabolic alkalosis | 17.53 | 9.61 | 40 | 244678 | 2691 | 50357715 |
Staring | 17.44 | 9.61 | 28 | 244690 | 1446 | 50358960 |
Self-medication | 17.42 | 9.61 | 36 | 244682 | 2263 | 50358143 |
Tendonitis | 17.36 | 9.61 | 34 | 244684 | 16671 | 50343735 |
Monocyte count decreased | 17.29 | 9.61 | 32 | 244686 | 1854 | 50358552 |
Suspected suicide attempt | 17.14 | 9.61 | 9 | 244709 | 99 | 50360307 |
Pregnancy | 17.14 | 9.61 | 79 | 244639 | 29498 | 50330908 |
Hyperchloraemia | 17.14 | 9.61 | 19 | 244699 | 682 | 50359724 |
Metabolic encephalopathy | 16.99 | 9.61 | 59 | 244659 | 5062 | 50355344 |
Neonatal behavioural syndrome | 16.94 | 9.61 | 7 | 244711 | 42 | 50360364 |
Gastrointestinal sounds abnormal | 16.81 | 9.61 | 47 | 244671 | 3587 | 50356819 |
Delusion of grandeur | 16.78 | 9.61 | 10 | 244708 | 143 | 50360263 |
Inappropriate antidiuretic hormone secretion | 16.76 | 9.61 | 115 | 244603 | 13028 | 50347378 |
Hypokalaemia | 16.69 | 9.61 | 550 | 244168 | 87442 | 50272964 |
Computerised tomogram thorax | 16.66 | 9.61 | 10 | 244708 | 145 | 50360261 |
Autonomic nervous system imbalance | 16.51 | 9.61 | 36 | 244682 | 2349 | 50358057 |
Anxiety disorder | 16.50 | 9.61 | 47 | 244671 | 3626 | 50356780 |
Premature delivery | 16.35 | 9.61 | 59 | 244659 | 23604 | 50336802 |
Paralysis | 16.33 | 9.61 | 84 | 244634 | 8580 | 50351826 |
Compartment syndrome | 16.16 | 9.61 | 32 | 244686 | 1950 | 50358456 |
Tracheal atresia | 16.10 | 9.61 | 6 | 244712 | 26 | 50360380 |
Hypervigilance | 16.07 | 9.61 | 13 | 244705 | 311 | 50360095 |
Device use error | 16.05 | 9.61 | 3 | 244715 | 5263 | 50355143 |
Hyperprolactinaemia | 16.04 | 9.61 | 44 | 244674 | 3321 | 50357085 |
Logorrhoea | 16 | 9.61 | 35 | 244683 | 2289 | 50358117 |
Asthma | 16.00 | 9.61 | 320 | 244398 | 89017 | 50271389 |
Cardiac failure | 15.93 | 9.61 | 265 | 244453 | 75775 | 50284631 |
Dementia | 15.90 | 9.61 | 132 | 244586 | 15865 | 50344541 |
Uveitis | 15.88 | 9.61 | 13 | 244705 | 9297 | 50351109 |
Atonic seizures | 15.68 | 9.61 | 17 | 244701 | 595 | 50359811 |
Pruritus allergic | 15.68 | 9.61 | 23 | 244695 | 1097 | 50359309 |
Cardiac malposition | 15.57 | 9.61 | 7 | 244711 | 53 | 50360353 |
Immunodeficiency | 15.57 | 9.61 | 30 | 244688 | 14798 | 50345608 |
Suspected suicide | 15.47 | 9.61 | 59 | 244659 | 5298 | 50355108 |
No adverse event | 15.41 | 9.61 | 97 | 244621 | 33481 | 50326925 |
Angioedema | 15.23 | 9.61 | 113 | 244605 | 37563 | 50322843 |
Respiratory alkalosis | 15.19 | 9.61 | 36 | 244682 | 2483 | 50357923 |
Platelet production decreased | 15.12 | 9.61 | 4 | 244714 | 3 | 50360403 |
Anomalous pulmonary venous connection | 15.04 | 9.61 | 7 | 244711 | 58 | 50360348 |
Upper respiratory tract infection | 15.03 | 9.61 | 226 | 244492 | 65672 | 50294734 |
Central nervous system necrosis | 15.02 | 9.61 | 9 | 244709 | 130 | 50360276 |
Nausea | 14.94 | 9.61 | 3733 | 240985 | 701665 | 49658741 |
Bone density decreased | 14.87 | 9.61 | 19 | 244699 | 11056 | 50349350 |
Psychotic behaviour | 14.83 | 9.61 | 16 | 244702 | 557 | 50359849 |
Apathy | 14.80 | 9.61 | 74 | 244644 | 7474 | 50352932 |
Blood sodium decreased | 14.80 | 9.61 | 162 | 244556 | 20985 | 50339421 |
Therapy cessation | 14.77 | 9.61 | 70 | 244648 | 25941 | 50334465 |
Unintentional medical device removal | 14.75 | 9.61 | 4 | 244714 | 5431 | 50354975 |
Device malfunction | 14.68 | 9.61 | 32 | 244686 | 15089 | 50345317 |
Morose | 14.66 | 9.61 | 6 | 244712 | 35 | 50360371 |
Squamous cell carcinoma of the oral cavity | 14.63 | 9.61 | 12 | 244706 | 293 | 50360113 |
Acute generalised exanthematous pustulosis | 14.61 | 9.61 | 13 | 244705 | 8925 | 50351481 |
Electrocardiogram T wave abnormal | 14.47 | 9.61 | 33 | 244685 | 2220 | 50358186 |
Tooth hypoplasia | 14.45 | 9.61 | 7 | 244711 | 64 | 50360342 |
Product complaint | 14.43 | 9.61 | 100 | 244618 | 11366 | 50349040 |
Visceral congestion | 14.39 | 9.61 | 12 | 244706 | 300 | 50360106 |
Skin reaction | 14.37 | 9.61 | 21 | 244697 | 11547 | 50348859 |
Respiratory disorder | 14.36 | 9.61 | 90 | 244628 | 31097 | 50329309 |
Anger | 14.35 | 9.61 | 99 | 244619 | 11234 | 50349172 |
Transient aphasia | 14.25 | 9.61 | 6 | 244712 | 38 | 50360368 |
Joint stiffness | 14.20 | 9.61 | 87 | 244631 | 30221 | 50330185 |
Diaphragmatic rupture | 14.15 | 9.61 | 11 | 244707 | 248 | 50360158 |
Loss of libido | 14.15 | 9.61 | 23 | 244695 | 1200 | 50359206 |
Lupus-like syndrome | 14.12 | 9.61 | 15 | 244703 | 9476 | 50350930 |
Sleep disorder | 14.12 | 9.61 | 370 | 244348 | 56913 | 50303493 |
Hepatocellular injury | 14.05 | 9.61 | 71 | 244647 | 25876 | 50334530 |
pH urine increased | 14.04 | 9.61 | 13 | 244705 | 375 | 50360031 |
Cough | 14.01 | 9.61 | 991 | 243727 | 240273 | 50120133 |
Vision blurred | 14.00 | 9.61 | 488 | 244230 | 78159 | 50282247 |
Oppositional defiant disorder | 13.99 | 9.61 | 6 | 244712 | 40 | 50360366 |
Joint effusion | 13.97 | 9.61 | 26 | 244692 | 12995 | 50347411 |
Ductus arteriosus premature closure | 13.93 | 9.61 | 12 | 244706 | 314 | 50360092 |
Areflexia | 13.90 | 9.61 | 37 | 244681 | 2743 | 50357663 |
Osteonecrosis of jaw | 13.90 | 9.61 | 96 | 244622 | 32430 | 50327976 |
Brain death | 13.88 | 9.61 | 37 | 244681 | 2746 | 50357660 |
Deep vein thrombosis | 13.85 | 9.61 | 458 | 244260 | 72846 | 50287560 |
Nervousness | 13.85 | 9.61 | 199 | 244519 | 27452 | 50332954 |
Balance disorder | 13.84 | 9.61 | 443 | 244275 | 70147 | 50290259 |
Schizoaffective disorder | 13.82 | 9.61 | 32 | 244686 | 2174 | 50358232 |
Suicidal behaviour | 13.69 | 9.61 | 33 | 244685 | 2301 | 50358105 |
Irritability | 13.61 | 9.61 | 203 | 244515 | 28223 | 50332183 |
Polyarthritis | 13.60 | 9.61 | 11 | 244707 | 7916 | 50352490 |
Muscle twitching | 13.60 | 9.61 | 124 | 244594 | 15307 | 50345099 |
Oxygen saturation abnormal | 13.55 | 9.61 | 36 | 244682 | 2666 | 50357740 |
Injection site rash | 13.53 | 9.61 | 37 | 244681 | 16140 | 50344266 |
Pressure of speech | 13.52 | 9.61 | 15 | 244703 | 539 | 50359867 |
Therapeutic product ineffective | 13.51 | 9.61 | 23 | 244695 | 1247 | 50359159 |
Bulimia nervosa | 13.51 | 9.61 | 13 | 244705 | 394 | 50360012 |
Laryngitis | 13.50 | 9.61 | 20 | 244698 | 10936 | 50349470 |
Liver disorder | 13.49 | 9.61 | 115 | 244603 | 37107 | 50323299 |
Inappropriate affect | 13.42 | 9.61 | 18 | 244700 | 789 | 50359617 |
Cognitive disorder | 13.31 | 9.61 | 293 | 244425 | 43830 | 50316576 |
Secondary immunodeficiency | 13.29 | 9.61 | 22 | 244696 | 1166 | 50359240 |
Hypotonia neonatal | 13.28 | 9.61 | 20 | 244698 | 977 | 50359429 |
Drug screen false positive | 13.21 | 9.61 | 18 | 244700 | 801 | 50359605 |
Pleurothotonus | 13.11 | 9.61 | 23 | 244695 | 1278 | 50359128 |
Vasoconstriction | 13.07 | 9.61 | 14 | 244704 | 483 | 50359923 |
Drug tolerance decreased | 13.06 | 9.61 | 15 | 244703 | 9145 | 50351261 |
Antidepressant drug level below therapeutic | 13.01 | 9.61 | 3 | 244715 | 0 | 50360406 |
Thinking abnormal | 12.97 | 9.61 | 85 | 244633 | 9482 | 50350924 |
Ulcer | 12.90 | 9.61 | 52 | 244666 | 20148 | 50340258 |
Induced abortion failed | 12.88 | 9.61 | 10 | 244708 | 225 | 50360181 |
Cyanosis | 12.87 | 9.61 | 121 | 244597 | 15063 | 50345343 |
Vulvar basal cell carcinoma | 12.85 | 9.61 | 5 | 244713 | 25 | 50360381 |
Euthanasia | 12.85 | 9.61 | 5 | 244713 | 25 | 50360381 |
Gastrooesophageal reflux disease | 12.81 | 9.61 | 471 | 244247 | 75957 | 50284449 |
Therapy interrupted | 12.79 | 9.61 | 52 | 244666 | 20100 | 50340306 |
Cerebellar haematoma | 12.77 | 9.61 | 12 | 244706 | 353 | 50360053 |
Drug level increased | 12.75 | 9.61 | 146 | 244572 | 19122 | 50341284 |
Neutrophil Pelger-Huet anomaly present | 12.74 | 9.61 | 7 | 244711 | 85 | 50360321 |
Congenital pneumonia | 12.68 | 9.61 | 4 | 244714 | 9 | 50360397 |
Inappropriate schedule of product administration | 12.65 | 9.61 | 258 | 244460 | 71573 | 50288833 |
Urine ketone body present | 12.64 | 9.61 | 32 | 244686 | 2301 | 50358105 |
Blood creatine increased | 12.64 | 9.61 | 52 | 244666 | 4835 | 50355571 |
Non-small cell lung cancer | 12.63 | 9.61 | 37 | 244681 | 2900 | 50357506 |
Coeliac disease | 12.62 | 9.61 | 14 | 244704 | 8671 | 50351735 |
Medication error | 12.61 | 9.61 | 245 | 244473 | 35859 | 50324547 |
Incoherent | 12.56 | 9.61 | 47 | 244671 | 4183 | 50356223 |
Left ventricle outflow tract obstruction | 12.55 | 9.61 | 10 | 244708 | 234 | 50360172 |
Sensory loss | 12.54 | 9.61 | 72 | 244646 | 7666 | 50352740 |
Myocardial reperfusion injury | 12.53 | 9.61 | 5 | 244713 | 27 | 50360379 |
Tachyphrenia | 12.53 | 9.61 | 22 | 244696 | 1223 | 50359183 |
Drug abuser | 12.52 | 9.61 | 36 | 244682 | 2792 | 50357614 |
Carbohydrate antigen 125 increased | 12.51 | 9.61 | 33 | 244685 | 2434 | 50357972 |
Surgery | 12.49 | 9.61 | 90 | 244628 | 30115 | 50330291 |
Anaphylactic reaction | 12.46 | 9.61 | 185 | 244533 | 53870 | 50306536 |
Disease progression | 12.45 | 9.61 | 575 | 244143 | 95291 | 50265115 |
Bronchiectasis | 12.45 | 9.61 | 19 | 244699 | 10264 | 50350142 |
False positive investigation result | 12.44 | 9.61 | 14 | 244704 | 511 | 50359895 |
Wheezing | 12.42 | 9.61 | 218 | 244500 | 61829 | 50298577 |
Fear | 12.36 | 9.61 | 116 | 244602 | 14433 | 50345973 |
Enthesopathy | 12.32 | 9.61 | 10 | 244708 | 7183 | 50353223 |
Hypersexuality | 12.32 | 9.61 | 13 | 244705 | 441 | 50359965 |
Stereotypy | 12.30 | 9.61 | 12 | 244706 | 370 | 50360036 |
Gastric ulcer | 12.29 | 9.61 | 57 | 244661 | 21248 | 50339158 |
Red cell distribution width increased | 12.19 | 9.61 | 77 | 244641 | 8482 | 50351924 |
Injection site warmth | 12.14 | 9.61 | 31 | 244687 | 13835 | 50346571 |
Rabbit syndrome | 12.12 | 9.61 | 11 | 244707 | 309 | 50360097 |
Leukopenia neonatal | 12.10 | 9.61 | 5 | 244713 | 30 | 50360376 |
Toxicologic test abnormal | 12.09 | 9.61 | 15 | 244703 | 608 | 50359798 |
Hypoaesthesia oral | 12.02 | 9.61 | 91 | 244627 | 10637 | 50349769 |
Arterial spasm | 12.01 | 9.61 | 6 | 244712 | 59 | 50360347 |
Chronic obstructive pulmonary disease | 12.00 | 9.61 | 341 | 244377 | 53094 | 50307312 |
Hypopnoea | 11.96 | 9.61 | 31 | 244687 | 2262 | 50358144 |
Parachute mitral valve | 11.94 | 9.61 | 7 | 244711 | 97 | 50360309 |
Newborn persistent pulmonary hypertension | 11.93 | 9.61 | 8 | 244710 | 142 | 50360264 |
Tachyphylaxis | 11.86 | 9.61 | 10 | 244708 | 254 | 50360152 |
Hypoprolactinaemia | 11.86 | 9.61 | 4 | 244714 | 12 | 50360394 |
Autologous bone marrow transplantation therapy | 11.86 | 9.61 | 4 | 244714 | 12 | 50360394 |
Depressive delusion | 11.86 | 9.61 | 4 | 244714 | 12 | 50360394 |
Blood immunoglobulin M decreased | 11.83 | 9.61 | 16 | 244702 | 707 | 50359699 |
Fibromyalgia | 11.82 | 9.61 | 293 | 244425 | 44685 | 50315721 |
Febrile bone marrow aplasia | 11.81 | 9.61 | 8 | 244710 | 6303 | 50354103 |
Hypercapnia | 11.79 | 9.61 | 49 | 244669 | 4578 | 50355828 |
Impaired driving ability | 11.75 | 9.61 | 44 | 244674 | 3917 | 50356489 |
Hypernatraemia | 11.72 | 9.61 | 61 | 244657 | 6260 | 50354146 |
Acute respiratory failure | 11.70 | 9.61 | 200 | 244518 | 28582 | 50331824 |
Water intoxication | 11.69 | 9.61 | 12 | 244706 | 394 | 50360012 |
Drug screen negative | 11.66 | 9.61 | 10 | 244708 | 260 | 50360146 |
Hypoxic-ischaemic encephalopathy | 11.66 | 9.61 | 43 | 244675 | 3799 | 50356607 |
Device dislocation | 11.64 | 9.61 | 59 | 244659 | 21487 | 50338919 |
Melaena | 11.62 | 9.61 | 79 | 244639 | 26785 | 50333621 |
Glaucoma | 11.59 | 9.61 | 38 | 244680 | 15648 | 50344758 |
Bone marrow failure | 11.57 | 9.61 | 82 | 244636 | 27542 | 50332864 |
Dependence | 11.53 | 9.61 | 27 | 244691 | 1848 | 50358558 |
Basophil count increased | 11.52 | 9.61 | 17 | 244701 | 815 | 50359591 |
Pleural adhesion | 11.51 | 9.61 | 7 | 244711 | 104 | 50360302 |
White blood cell count decreased | 11.50 | 9.61 | 682 | 244036 | 116040 | 50244366 |
Pupillary reflex impaired | 11.47 | 9.61 | 27 | 244691 | 1854 | 50358552 |
Disease recurrence | 11.42 | 9.61 | 54 | 244664 | 20027 | 50340379 |
Respiratory rate decreased | 11.36 | 9.61 | 37 | 244681 | 3071 | 50357335 |
Neuropsychiatric symptoms | 11.33 | 9.61 | 14 | 244704 | 565 | 50359841 |
Gait disturbance | 11.31 | 9.61 | 857 | 243861 | 149148 | 50211258 |
Bronchitis | 11.29 | 9.61 | 401 | 244317 | 103758 | 50256648 |
Polydipsia | 11.25 | 9.61 | 37 | 244681 | 3087 | 50357319 |
Schizoaffective disorder bipolar type | 11.23 | 9.61 | 7 | 244711 | 109 | 50360297 |
Kluver-Bucy syndrome | 11.19 | 9.61 | 4 | 244714 | 15 | 50360391 |
Gallbladder disorder | 11.14 | 9.61 | 127 | 244591 | 16615 | 50343791 |
Drug diversion | 11.13 | 9.61 | 16 | 244702 | 749 | 50359657 |
Lymphocyte count decreased | 11.13 | 9.61 | 184 | 244534 | 26123 | 50334283 |
Periorbital haemorrhage | 11.12 | 9.61 | 6 | 244712 | 70 | 50360336 |
Delusional perception | 11.10 | 9.61 | 9 | 244709 | 216 | 50360190 |
Blood magnesium decreased | 11.04 | 9.61 | 92 | 244626 | 11068 | 50349338 |
Haemoglobin urine | 11.01 | 9.61 | 7 | 244711 | 113 | 50360293 |
Incision site complication | 11.01 | 9.61 | 14 | 244704 | 582 | 50359824 |
Amegakaryocytic thrombocytopenia | 10.99 | 9.61 | 4 | 244714 | 16 | 50360390 |
Natural killer cell count | 10.99 | 9.61 | 4 | 244714 | 16 | 50360390 |
Eczema eyelids | 10.96 | 9.61 | 7 | 244711 | 114 | 50360292 |
Anti-neuronal antibody positive | 10.95 | 9.61 | 3 | 244715 | 3 | 50360403 |
Patient restraint | 10.95 | 9.61 | 3 | 244715 | 3 | 50360403 |
Benzodiazepine drug level | 10.95 | 9.61 | 3 | 244715 | 3 | 50360403 |
Antidepressant drug level decreased | 10.95 | 9.61 | 3 | 244715 | 3 | 50360403 |
Rash pruritic | 10.94 | 9.61 | 164 | 244554 | 47682 | 50312724 |
Tuberculosis | 10.94 | 9.61 | 20 | 244698 | 10063 | 50350343 |
Pathogen resistance | 10.93 | 9.61 | 7 | 244711 | 5682 | 50354724 |
Finger deformity | 10.91 | 9.61 | 7 | 244711 | 5675 | 50354731 |
Waxy flexibility | 10.91 | 9.61 | 7 | 244711 | 115 | 50360291 |
Osteoradionecrosis | 10.91 | 9.61 | 7 | 244711 | 115 | 50360291 |
Blood albumin increased | 10.87 | 9.61 | 17 | 244701 | 858 | 50359548 |
Systolic hypertension | 10.84 | 9.61 | 12 | 244706 | 430 | 50359976 |
Drug resistance | 10.84 | 9.61 | 51 | 244667 | 18938 | 50341468 |
Limbic encephalitis | 10.83 | 9.61 | 9 | 244709 | 224 | 50360182 |
Dysmetropsia | 10.77 | 9.61 | 6 | 244712 | 75 | 50360331 |
Inflammatory marker increased | 10.73 | 9.61 | 7 | 244711 | 5627 | 50354779 |
Liver injury | 10.71 | 9.61 | 73 | 244645 | 24733 | 50335673 |
Injection site haemorrhage | 10.68 | 9.61 | 60 | 244658 | 21286 | 50339120 |
Wound infection fungal | 10.65 | 9.61 | 7 | 244711 | 120 | 50360286 |
On and off phenomenon | 10.57 | 9.61 | 22 | 244696 | 1390 | 50359016 |
Cardiac failure congestive | 10.53 | 9.61 | 319 | 244399 | 84063 | 50276343 |
Oropharyngeal swelling | 10.49 | 9.61 | 16 | 244702 | 790 | 50359616 |
Platelet morphology abnormal | 10.49 | 9.61 | 3 | 244715 | 4 | 50360402 |
Abortion spontaneous complete | 10.49 | 9.61 | 3 | 244715 | 4 | 50360402 |
Tri-iodothyronine free decreased | 10.48 | 9.61 | 10 | 244708 | 300 | 50360106 |
Antidepressant drug level above therapeutic | 10.45 | 9.61 | 11 | 244707 | 372 | 50360034 |
Affective ambivalence | 10.44 | 9.61 | 4 | 244714 | 19 | 50360387 |
Disinhibition | 10.43 | 9.61 | 16 | 244702 | 794 | 50359612 |
Tongue movement disturbance | 10.40 | 9.61 | 9 | 244709 | 237 | 50360169 |
Hyponatraemic syndrome | 10.40 | 9.61 | 13 | 244705 | 531 | 50359875 |
Cerebral atrophy | 10.40 | 9.61 | 47 | 244671 | 4554 | 50355852 |
Reversible cerebral vasoconstriction syndrome | 10.39 | 9.61 | 28 | 244690 | 2091 | 50358315 |
Wrong strength | 10.39 | 9.61 | 5 | 244713 | 45 | 50360361 |
Benzodiazepine drug level increased | 10.35 | 9.61 | 8 | 244710 | 179 | 50360227 |
Apallic syndrome | 10.35 | 9.61 | 14 | 244704 | 619 | 50359787 |
Cyclic vomiting syndrome | 10.29 | 9.61 | 5 | 244713 | 46 | 50360360 |
Foot operation | 10.29 | 9.61 | 7 | 244711 | 5503 | 50354903 |
Gallbladder cholesterolosis | 10.20 | 9.61 | 15 | 244703 | 717 | 50359689 |
Floppy infant | 10.18 | 9.61 | 6 | 244712 | 84 | 50360322 |
Hypomania | 10.17 | 9.61 | 46 | 244672 | 4459 | 50355947 |
Patent ductus arteriosus | 10.16 | 9.61 | 41 | 244677 | 3779 | 50356627 |
Scleral haemorrhage | 10.12 | 9.61 | 4 | 244714 | 21 | 50360385 |
Impaired work ability | 10.11 | 9.61 | 33 | 244685 | 13607 | 50346799 |
Urine abnormality | 10.08 | 9.61 | 58 | 244660 | 6180 | 50354226 |
Hyperthyroidism | 10.07 | 9.61 | 28 | 244690 | 12147 | 50348259 |
Neutrophil count increased | 10.05 | 9.61 | 109 | 244609 | 14086 | 50346320 |
Genital herpes simplex | 10.01 | 9.61 | 8 | 244710 | 188 | 50360218 |
Ear pain | 9.97 | 9.61 | 88 | 244630 | 28195 | 50332211 |
Culture urine positive | 9.96 | 9.61 | 38 | 244680 | 3413 | 50356993 |
Antidepressant drug level increased | 9.94 | 9.61 | 9 | 244709 | 252 | 50360154 |
Drug clearance decreased | 9.92 | 9.61 | 19 | 244699 | 1130 | 50359276 |
Cholangitis infective | 9.91 | 9.61 | 8 | 244710 | 191 | 50360215 |
Panic disorder | 9.89 | 9.61 | 29 | 244689 | 2274 | 50358132 |
Intestinal strangulation | 9.88 | 9.61 | 6 | 244712 | 89 | 50360317 |
Oedema | 9.86 | 9.61 | 261 | 244457 | 69920 | 50290486 |
Amnesia | 9.85 | 9.61 | 271 | 244447 | 41989 | 50318417 |
Macrophages increased | 9.82 | 9.61 | 4 | 244714 | 23 | 50360383 |
Hepatic cytolysis | 9.78 | 9.61 | 15 | 244703 | 8088 | 50352318 |
Crush injury | 9.74 | 9.61 | 3 | 244715 | 6 | 50360400 |
Brain herniation | 9.72 | 9.61 | 35 | 244683 | 3057 | 50357349 |
Sciatica | 9.69 | 9.61 | 62 | 244656 | 21320 | 50339086 |
Morbihan disease | 9.68 | 9.61 | 4 | 244714 | 24 | 50360382 |
Dysaesthesia pharynx | 9.68 | 9.61 | 7 | 244711 | 141 | 50360265 |
Malnutrition | 9.68 | 9.61 | 102 | 244616 | 13087 | 50347319 |
Impaired quality of life | 9.67 | 9.61 | 9 | 244709 | 6047 | 50354359 |
Posture abnormal | 9.65 | 9.61 | 27 | 244691 | 2062 | 50358344 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Sopor | 788.36 | 10.11 | 542 | 138106 | 10392 | 29425487 |
Drug abuse | 370.00 | 10.11 | 1012 | 137636 | 78871 | 29357008 |
Agitation | 353.59 | 10.11 | 758 | 137890 | 50546 | 29385333 |
Neuroleptic malignant syndrome | 331.98 | 10.11 | 394 | 138254 | 15754 | 29420125 |
Bradyphrenia | 289.82 | 10.11 | 203 | 138445 | 4011 | 29431868 |
Catatonia | 285.97 | 10.11 | 206 | 138442 | 4262 | 29431617 |
Intentional self-injury | 272.73 | 10.11 | 314 | 138334 | 12147 | 29423732 |
Sedation | 250.31 | 10.11 | 356 | 138292 | 17049 | 29418830 |
Aggression | 227.58 | 10.11 | 510 | 138138 | 35031 | 29400848 |
Completed suicide | 217.08 | 10.11 | 918 | 137730 | 89328 | 29346551 |
Suicide attempt | 215.64 | 10.11 | 487 | 138161 | 33623 | 29402256 |
Psychotic disorder | 203.14 | 10.11 | 352 | 138296 | 20002 | 29415877 |
Somnolence | 200.40 | 10.11 | 922 | 137726 | 93033 | 29342846 |
Delirium | 187.01 | 10.11 | 504 | 138144 | 38893 | 29396986 |
Anxiety | 154.20 | 10.11 | 799 | 137849 | 84566 | 29351313 |
Schizophrenia | 141.23 | 10.11 | 164 | 138484 | 6401 | 29429478 |
Confusional state | 140.40 | 10.11 | 1053 | 137595 | 126824 | 29309055 |
Extrapyramidal disorder | 130.56 | 10.11 | 204 | 138444 | 10627 | 29425252 |
Hallucination, auditory | 118.87 | 10.11 | 183 | 138465 | 9410 | 29426469 |
Drug dependence | 118.82 | 10.11 | 287 | 138361 | 20694 | 29415185 |
Drug withdrawal syndrome | 118.36 | 10.11 | 261 | 138387 | 17723 | 29418156 |
Intentional overdose | 116.09 | 10.11 | 421 | 138227 | 38107 | 29397772 |
Dysarthria | 113.58 | 10.11 | 361 | 138287 | 30550 | 29405329 |
Restlessness | 109.79 | 10.11 | 288 | 138360 | 21857 | 29414022 |
Interstitial lung disease | 107.45 | 10.11 | 69 | 138579 | 57649 | 29378230 |
Overdose | 107.39 | 10.11 | 691 | 137957 | 79128 | 29356751 |
Muscle rigidity | 100.80 | 10.11 | 168 | 138480 | 9243 | 29426636 |
Suicidal ideation | 93.51 | 10.11 | 366 | 138282 | 34350 | 29401529 |
Mental status changes | 93.09 | 10.11 | 367 | 138281 | 34560 | 29401319 |
Respiratory depression | 82 | 10.11 | 190 | 138458 | 13333 | 29422546 |
Abnormal behaviour | 79.45 | 10.11 | 264 | 138384 | 22863 | 29413016 |
Parkinsonism | 78.05 | 10.11 | 130 | 138518 | 7148 | 29428731 |
Tachycardia | 75.82 | 10.11 | 590 | 138058 | 71820 | 29364059 |
Toxicity to various agents | 75.59 | 10.11 | 1188 | 137460 | 172473 | 29263406 |
Depressed level of consciousness | 70.25 | 10.11 | 351 | 138297 | 36591 | 29399288 |
Disorientation | 69.85 | 10.11 | 299 | 138349 | 29216 | 29406663 |
Akathisia | 69.08 | 10.11 | 118 | 138530 | 6624 | 29429255 |
Acute kidney injury | 68.06 | 10.11 | 857 | 137791 | 264410 | 29171469 |
Delusion | 67.36 | 10.11 | 157 | 138491 | 11059 | 29424820 |
Joint swelling | 65.23 | 10.11 | 82 | 138566 | 49548 | 29386331 |
Bradykinesia | 64.13 | 10.11 | 80 | 138568 | 3367 | 29432512 |
Renal impairment | 60.49 | 10.11 | 188 | 138460 | 81145 | 29354734 |
Granulocytopenia | 58.91 | 10.11 | 103 | 138545 | 5891 | 29429988 |
Unresponsive to stimuli | 57.50 | 10.11 | 252 | 138396 | 24874 | 29411005 |
Withdrawal syndrome | 55.54 | 10.11 | 144 | 138504 | 10848 | 29425031 |
Seizure | 54.18 | 10.11 | 671 | 137977 | 92452 | 29343427 |
Speech disorder | 53.93 | 10.11 | 236 | 138412 | 23280 | 29412599 |
Mental impairment | 53.85 | 10.11 | 127 | 138521 | 9014 | 29426865 |
Hallucination | 52.84 | 10.11 | 375 | 138273 | 44337 | 29391542 |
Rheumatoid arthritis | 52.60 | 10.11 | 44 | 138604 | 32108 | 29403771 |
Anaemia | 52.29 | 10.11 | 647 | 138001 | 200304 | 29235575 |
Psychomotor hyperactivity | 51.56 | 10.11 | 117 | 138531 | 8096 | 29427783 |
Paranoia | 50.53 | 10.11 | 130 | 138518 | 9747 | 29426132 |
Product dose omission issue | 49.97 | 10.11 | 257 | 138391 | 96126 | 29339753 |
Ataxia | 49.71 | 10.11 | 147 | 138501 | 11956 | 29423923 |
Dystonia | 48.52 | 10.11 | 127 | 138521 | 9622 | 29426257 |
Psoriasis | 48.08 | 10.11 | 48 | 138600 | 32179 | 29403700 |
Electrocardiogram QT prolonged | 47.40 | 10.11 | 311 | 138337 | 35826 | 29400053 |
Major depression | 47.28 | 10.11 | 73 | 138575 | 3762 | 29432117 |
Dyskinesia | 47.28 | 10.11 | 203 | 138445 | 19858 | 29416021 |
Cytomegalovirus infection | 47.09 | 10.11 | 25 | 138623 | 23190 | 29412689 |
Refusal of treatment by patient | 46.57 | 10.11 | 81 | 138567 | 4613 | 29431266 |
Blood creatine phosphokinase increased | 45.78 | 10.11 | 337 | 138311 | 40307 | 29395572 |
Sedation complication | 45.67 | 10.11 | 42 | 138606 | 1240 | 29434639 |
Poverty of speech | 45.24 | 10.11 | 22 | 138626 | 210 | 29435669 |
Hypokinesia | 44.55 | 10.11 | 105 | 138543 | 7449 | 29428430 |
Treatment failure | 44.52 | 10.11 | 65 | 138583 | 36874 | 29399005 |
Drug ineffective | 44.12 | 10.11 | 1332 | 137316 | 361838 | 29074041 |
COVID-19 | 43.77 | 10.11 | 63 | 138585 | 35951 | 29399928 |
Miosis | 43.67 | 10.11 | 108 | 138540 | 7901 | 29427978 |
Pruritus | 43.43 | 10.11 | 345 | 138303 | 116504 | 29319375 |
Peripheral swelling | 42.15 | 10.11 | 155 | 138493 | 63584 | 29372295 |
Hyperkalaemia | 40.79 | 10.11 | 149 | 138499 | 61243 | 29374636 |
Stupor | 40.72 | 10.11 | 57 | 138591 | 2687 | 29433192 |
Salivary hypersecretion | 40.49 | 10.11 | 100 | 138548 | 7309 | 29428570 |
Arthralgia | 40.36 | 10.11 | 439 | 138209 | 139178 | 29296701 |
Myelosuppression | 40.14 | 10.11 | 5 | 138643 | 12222 | 29423657 |
Multiple organ dysfunction syndrome | 40.10 | 10.11 | 156 | 138492 | 62960 | 29372919 |
Serotonin syndrome | 39.58 | 10.11 | 175 | 138473 | 17337 | 29418542 |
Sinus tachycardia | 39.05 | 10.11 | 157 | 138491 | 14912 | 29420967 |
Antipsychotic drug level increased | 38.96 | 10.11 | 61 | 138587 | 3182 | 29432697 |
Visceral congestion | 38.53 | 10.11 | 26 | 138622 | 482 | 29435397 |
Homicide | 38.22 | 10.11 | 33 | 138615 | 895 | 29434984 |
Withdrawal catatonia | 38.05 | 10.11 | 15 | 138633 | 81 | 29435798 |
Gait spastic | 37.84 | 10.11 | 29 | 138619 | 661 | 29435218 |
Psoriatic arthropathy | 37.71 | 10.11 | 11 | 138637 | 14680 | 29421199 |
Hepatic function abnormal | 37.43 | 10.11 | 80 | 138568 | 39179 | 29396700 |
Self-injurious ideation | 37.19 | 10.11 | 41 | 138607 | 1510 | 29434369 |
Irritability | 36.95 | 10.11 | 203 | 138445 | 21949 | 29413930 |
Drug screen positive | 36.94 | 10.11 | 65 | 138583 | 3736 | 29432143 |
Needle fatigue | 36.88 | 10.11 | 27 | 138621 | 573 | 29435306 |
Psychotic symptom | 36.75 | 10.11 | 39 | 138609 | 1375 | 29434504 |
Coma | 36.69 | 10.11 | 313 | 138335 | 39137 | 29396742 |
Dysphoria | 36.46 | 10.11 | 47 | 138601 | 2045 | 29433834 |
Movement disorder | 36.17 | 10.11 | 118 | 138530 | 10119 | 29425760 |
Depression | 36.00 | 10.11 | 580 | 138068 | 84567 | 29351312 |
Drug reaction with eosinophilia and systemic symptoms | 36.00 | 10.11 | 47 | 138601 | 27945 | 29407934 |
Confabulation | 35.87 | 10.11 | 16 | 138632 | 123 | 29435756 |
Dyspnoea | 34.71 | 10.11 | 1219 | 137429 | 325513 | 29110366 |
Victim of child abuse | 34.70 | 10.11 | 30 | 138618 | 815 | 29435064 |
Synovitis | 34.44 | 10.11 | 5 | 138643 | 10885 | 29424994 |
Bone marrow failure | 34.37 | 10.11 | 47 | 138601 | 27402 | 29408477 |
Diet refusal | 34.19 | 10.11 | 20 | 138628 | 285 | 29435594 |
Treatment noncompliance | 33.92 | 10.11 | 212 | 138436 | 24015 | 29411864 |
Cardiac failure congestive | 33.86 | 10.11 | 215 | 138433 | 76366 | 29359513 |
Drug withdrawal convulsions | 33.74 | 10.11 | 34 | 138614 | 1127 | 29434752 |
Hyperammonaemic encephalopathy | 33.58 | 10.11 | 44 | 138604 | 1946 | 29433933 |
Negativism | 32.85 | 10.11 | 21 | 138627 | 354 | 29435525 |
Cardiac failure | 32.84 | 10.11 | 227 | 138421 | 79060 | 29356819 |
Status epilepticus | 32.53 | 10.11 | 118 | 138530 | 10676 | 29425203 |
Respiratory arrest | 32.47 | 10.11 | 220 | 138428 | 25613 | 29410266 |
Relapsing-remitting multiple sclerosis | 32.13 | 10.11 | 27 | 138621 | 705 | 29435174 |
Insomnia | 31.88 | 10.11 | 589 | 138059 | 88172 | 29347707 |
Myocardial infarction | 31.78 | 10.11 | 347 | 138301 | 109949 | 29325930 |
Cholestasis | 31.62 | 10.11 | 38 | 138610 | 23424 | 29412455 |
Drug interaction | 30.75 | 10.11 | 1173 | 137475 | 196212 | 29239667 |
Anaphylactic shock | 30.72 | 10.11 | 12 | 138636 | 13324 | 29422555 |
Off label use | 30.62 | 10.11 | 1128 | 137520 | 299672 | 29136207 |
Oropharyngeal spasm | 30.51 | 10.11 | 15 | 138633 | 147 | 29435732 |
Oral discharge | 30.39 | 10.11 | 14 | 138634 | 117 | 29435762 |
Amnesia | 30.38 | 10.11 | 196 | 138452 | 22447 | 29413432 |
Tremor | 30.36 | 10.11 | 499 | 138149 | 73039 | 29362840 |
Hypersensitivity | 30.35 | 10.11 | 136 | 138512 | 52767 | 29383112 |
Affect lability | 30.29 | 10.11 | 56 | 138592 | 3346 | 29432533 |
Acute myocardial infarction | 29.95 | 10.11 | 121 | 138527 | 48317 | 29387562 |
Pneumonia aspiration | 29.82 | 10.11 | 283 | 138365 | 36454 | 29399425 |
Febrile neutropenia | 29.64 | 10.11 | 712 | 137936 | 111528 | 29324351 |
Gastrointestinal haemorrhage | 29.45 | 10.11 | 235 | 138413 | 79298 | 29356581 |
Rash | 29.34 | 10.11 | 672 | 137976 | 189147 | 29246732 |
Mental disorder | 29.19 | 10.11 | 129 | 138519 | 12776 | 29423103 |
Hangover | 29.10 | 10.11 | 29 | 138619 | 948 | 29434931 |
Psychotic behaviour | 29.10 | 10.11 | 24 | 138624 | 610 | 29435269 |
Poisoning | 29.07 | 10.11 | 108 | 138540 | 9885 | 29425994 |
Psychomotor retardation | 29.06 | 10.11 | 51 | 138597 | 2925 | 29432954 |
Drug resistance | 28.91 | 10.11 | 35 | 138613 | 21505 | 29414374 |
Pain in extremity | 28.87 | 10.11 | 355 | 138293 | 110078 | 29325801 |
Mutism | 28.53 | 10.11 | 25 | 138623 | 692 | 29435187 |
Antipsychotic drug level decreased | 28.14 | 10.11 | 27 | 138621 | 842 | 29435037 |
Paradoxical drug reaction | 28.11 | 10.11 | 48 | 138600 | 2693 | 29433186 |
Haematuria | 28.09 | 10.11 | 109 | 138539 | 44030 | 29391849 |
Pleurothotonus | 27.63 | 10.11 | 29 | 138619 | 1009 | 29434870 |
Incoherent | 27.61 | 10.11 | 60 | 138588 | 4032 | 29431847 |
Parathyroid gland enlargement | 27.39 | 10.11 | 13 | 138635 | 117 | 29435762 |
Lethargy | 26.87 | 10.11 | 282 | 138366 | 37298 | 29398581 |
Impulsive behaviour | 26.83 | 10.11 | 39 | 138609 | 1904 | 29433975 |
Sexually inappropriate behaviour | 26.79 | 10.11 | 19 | 138629 | 383 | 29435496 |
Substance abuse | 26.51 | 10.11 | 81 | 138567 | 6706 | 29429173 |
Parkinsonian gait | 26.40 | 10.11 | 20 | 138628 | 448 | 29435431 |
Rhinitis perennial | 26.32 | 10.11 | 15 | 138633 | 203 | 29435676 |
Upper respiratory fungal infection | 26.30 | 10.11 | 13 | 138635 | 129 | 29435750 |
Diarrhoea | 26.23 | 10.11 | 1284 | 137364 | 331414 | 29104465 |
Multiple drug therapy | 25.98 | 10.11 | 18 | 138630 | 349 | 29435530 |
Angioedema | 25.72 | 10.11 | 71 | 138577 | 31844 | 29404035 |
Melaena | 25.39 | 10.11 | 69 | 138579 | 31107 | 29404772 |
Transplant rejection | 25.35 | 10.11 | 6 | 138642 | 9206 | 29426673 |
Myocardial fibrosis | 25.21 | 10.11 | 28 | 138620 | 1040 | 29434839 |
Anger | 24.74 | 10.11 | 109 | 138539 | 10781 | 29425098 |
Logorrhoea | 24.71 | 10.11 | 41 | 138607 | 2247 | 29433632 |
Muscle spasticity | 24.70 | 10.11 | 64 | 138584 | 4819 | 29431060 |
Coronary artery disease | 24.51 | 10.11 | 115 | 138533 | 44075 | 29391804 |
Drug intolerance | 24.49 | 10.11 | 130 | 138518 | 48249 | 29387630 |
Injection site pain | 24.10 | 10.11 | 75 | 138573 | 32371 | 29403508 |
Mania | 23.85 | 10.11 | 92 | 138556 | 8571 | 29427308 |
Forced expiratory volume | 23.67 | 10.11 | 11 | 138637 | 94 | 29435785 |
Panic reaction | 23.64 | 10.11 | 30 | 138618 | 1285 | 29434594 |
Delusion of grandeur | 23.54 | 10.11 | 18 | 138630 | 409 | 29435470 |
Micturition urgency | 23.34 | 10.11 | 65 | 138583 | 5108 | 29430771 |
Hypoglycaemia | 23.32 | 10.11 | 132 | 138516 | 48214 | 29387665 |
Adjustment disorder | 23.21 | 10.11 | 26 | 138622 | 975 | 29434904 |
Pathogen resistance | 22.91 | 10.11 | 5 | 138643 | 8111 | 29427768 |
Hyperosmolar state | 22.78 | 10.11 | 17 | 138631 | 372 | 29435507 |
Persecutory delusion | 22.63 | 10.11 | 38 | 138610 | 2103 | 29433776 |
Alcohol withdrawal syndrome | 22.61 | 10.11 | 30 | 138618 | 1343 | 29434536 |
Cerebrovascular accident | 22.52 | 10.11 | 241 | 138407 | 76670 | 29359209 |
Anaphylactic reaction | 22.47 | 10.11 | 61 | 138587 | 27512 | 29408367 |
Failure to thrive | 22.31 | 10.11 | 83 | 138565 | 7601 | 29428278 |
Jaundice | 22.27 | 10.11 | 67 | 138581 | 29229 | 29406650 |
Full blood count abnormal | 22.04 | 10.11 | 133 | 138515 | 14880 | 29420999 |
Social avoidant behaviour | 22.01 | 10.11 | 45 | 138603 | 2897 | 29432982 |
Nervousness | 21.89 | 10.11 | 108 | 138540 | 11198 | 29424681 |
Thinking abnormal | 21.88 | 10.11 | 64 | 138584 | 5172 | 29430707 |
Urticaria | 21.88 | 10.11 | 158 | 138490 | 54502 | 29381377 |
Bipolar disorder | 21.87 | 10.11 | 48 | 138600 | 3247 | 29432632 |
Priapism | 21.86 | 10.11 | 58 | 138590 | 4430 | 29431449 |
Erythema | 21.70 | 10.11 | 238 | 138410 | 75368 | 29360511 |
Neologism | 21.60 | 10.11 | 6 | 138642 | 7 | 29435872 |
Cerebral infarction | 21.33 | 10.11 | 53 | 138595 | 24622 | 29411257 |
Illusion | 21.21 | 10.11 | 21 | 138627 | 681 | 29435198 |
Prostate cancer | 21.16 | 10.11 | 56 | 138592 | 25471 | 29410408 |
Epstein-Barr virus infection | 21.07 | 10.11 | 3 | 138645 | 6626 | 29429253 |
Panic attack | 20.98 | 10.11 | 86 | 138562 | 8240 | 29427639 |
Aspiration | 20.97 | 10.11 | 99 | 138549 | 10081 | 29425798 |
Inappropriate antidiuretic hormone secretion | 20.86 | 10.11 | 104 | 138544 | 10828 | 29425051 |
Hallucination, visual | 20.77 | 10.11 | 131 | 138517 | 14884 | 29420995 |
Arthritis | 20.65 | 10.11 | 55 | 138593 | 24964 | 29410915 |
Growth hormone deficiency | 20.44 | 10.11 | 13 | 138635 | 217 | 29435662 |
Blood creatine phosphokinase | 20.42 | 10.11 | 9 | 138639 | 67 | 29435812 |
Bladder cancer | 20.40 | 10.11 | 11 | 138637 | 10116 | 29425763 |
Eczema | 20.16 | 10.11 | 21 | 138627 | 13805 | 29422074 |
Communication disorder | 19.90 | 10.11 | 38 | 138610 | 2327 | 29433552 |
Flight of ideas | 19.83 | 10.11 | 15 | 138633 | 335 | 29435544 |
Arthropathy | 19.66 | 10.11 | 45 | 138603 | 21509 | 29414370 |
Middle insomnia | 19.45 | 10.11 | 65 | 138583 | 5643 | 29430236 |
Oedema peripheral | 19.42 | 10.11 | 355 | 138293 | 103202 | 29332677 |
Contraindicated product administered | 19.33 | 10.11 | 35 | 138613 | 18231 | 29417648 |
Orgasmic sensation decreased | 19.33 | 10.11 | 8 | 138640 | 50 | 29435829 |
Blood sodium decreased | 19.30 | 10.11 | 127 | 138521 | 14640 | 29421239 |
Renal disorder | 19.16 | 10.11 | 49 | 138599 | 22546 | 29413333 |
Cerebral haemorrhage | 19.11 | 10.11 | 79 | 138569 | 31347 | 29404532 |
Visual acuity reduced | 19.10 | 10.11 | 25 | 138623 | 14851 | 29421028 |
Affective disorder | 19.03 | 10.11 | 44 | 138604 | 3082 | 29432797 |
Premature ejaculation | 18.88 | 10.11 | 10 | 138638 | 116 | 29435763 |
Dysphagia | 18.85 | 10.11 | 362 | 138286 | 54564 | 29381315 |
Drug eruption | 18.70 | 10.11 | 31 | 138617 | 16710 | 29419169 |
Pyrexia | 18.55 | 10.11 | 1132 | 137516 | 286490 | 29149389 |
Intentional product misuse | 18.53 | 10.11 | 246 | 138402 | 34415 | 29401464 |
Tubulointerstitial nephritis | 18.49 | 10.11 | 34 | 138614 | 17609 | 29418270 |
Plasma cell myeloma | 18.45 | 10.11 | 260 | 138388 | 36855 | 29399024 |
Hypertonic bladder | 18.35 | 10.11 | 28 | 138620 | 1428 | 29434451 |
Atrial fibrillation | 18.33 | 10.11 | 367 | 138281 | 105279 | 29330600 |
Hyperprolactinaemia | 18.28 | 10.11 | 26 | 138622 | 1244 | 29434635 |
Sexual relationship change | 18.22 | 10.11 | 6 | 138642 | 17 | 29435862 |
Schizoaffective disorder | 18.20 | 10.11 | 24 | 138624 | 1068 | 29434811 |
Faecaloma | 18.18 | 10.11 | 52 | 138596 | 4150 | 29431729 |
Memory impairment | 17.94 | 10.11 | 255 | 138393 | 36215 | 29399664 |
Intentional product use issue | 17.92 | 10.11 | 121 | 138527 | 42377 | 29393502 |
Sexual dysfunction | 17.89 | 10.11 | 64 | 138584 | 5750 | 29430129 |
Haematuria traumatic | 17.59 | 10.11 | 11 | 138637 | 178 | 29435701 |
Negative thoughts | 17.56 | 10.11 | 18 | 138630 | 609 | 29435270 |
Balance disorder | 17.43 | 10.11 | 252 | 138396 | 35918 | 29399961 |
Liver disorder | 17.35 | 10.11 | 69 | 138579 | 27680 | 29408199 |
Haematotoxicity | 17.22 | 10.11 | 5 | 138643 | 6694 | 29429185 |
Anxiolytic therapy | 17.07 | 10.11 | 6 | 138642 | 22 | 29435857 |
Floppy infant | 17.02 | 10.11 | 9 | 138639 | 104 | 29435775 |
Perseveration | 16.95 | 10.11 | 9 | 138639 | 105 | 29435774 |
Angina pectoris | 16.94 | 10.11 | 70 | 138578 | 27780 | 29408099 |
Oculogyric crisis | 16.91 | 10.11 | 26 | 138622 | 1335 | 29434544 |
Neutropenic sepsis | 16.88 | 10.11 | 18 | 138630 | 11709 | 29424170 |
Therapeutic product effect decreased | 16.71 | 10.11 | 76 | 138572 | 29375 | 29406504 |
Staring | 16.65 | 10.11 | 26 | 138622 | 1353 | 29434526 |
C-reactive protein abnormal | 16.58 | 10.11 | 5 | 138643 | 6531 | 29429348 |
Monoparesis | 16.54 | 10.11 | 31 | 138617 | 1872 | 29434007 |
Basal cell carcinoma | 16.50 | 10.11 | 34 | 138614 | 16876 | 29419003 |
Immune reconstitution inflammatory syndrome | 16.42 | 10.11 | 8 | 138640 | 7794 | 29428085 |
Haemophagocytic lymphohistiocytosis | 16.42 | 10.11 | 15 | 138633 | 10489 | 29425390 |
Pulmonary fibrosis | 16.36 | 10.11 | 30 | 138618 | 15552 | 29420327 |
Hyperventilation | 16.35 | 10.11 | 35 | 138613 | 2327 | 29433552 |
Cough | 16.23 | 10.11 | 461 | 138187 | 126266 | 29309613 |
Loss of consciousness | 16.10 | 10.11 | 458 | 138190 | 73598 | 29362281 |
Myalgia | 16.07 | 10.11 | 247 | 138401 | 73772 | 29362107 |
Nephropathy toxic | 16.06 | 10.11 | 16 | 138632 | 10740 | 29425139 |
Altered state of consciousness | 16.03 | 10.11 | 153 | 138495 | 19736 | 29416143 |
Urinary incontinence | 15.97 | 10.11 | 132 | 138516 | 16349 | 29419530 |
Nasal congestion | 15.97 | 10.11 | 41 | 138607 | 18838 | 29417041 |
Disturbance in attention | 15.90 | 10.11 | 162 | 138486 | 21262 | 29414617 |
Homicidal ideation | 15.89 | 10.11 | 36 | 138612 | 2488 | 29433391 |
Skin ulcer | 15.87 | 10.11 | 41 | 138607 | 18799 | 29417080 |
Infection | 15.70 | 10.11 | 259 | 138389 | 76492 | 29359387 |
Herpes zoster | 15.63 | 10.11 | 80 | 138568 | 29972 | 29405907 |
Posturing | 15.63 | 10.11 | 15 | 138633 | 468 | 29435411 |
Loose associations | 15.56 | 10.11 | 7 | 138641 | 55 | 29435824 |
Hepatic cytolysis | 15.49 | 10.11 | 10 | 138638 | 8337 | 29427542 |
Suicidal behaviour | 15.47 | 10.11 | 25 | 138623 | 1340 | 29434539 |
Drug therapy enhancement | 15.44 | 10.11 | 6 | 138642 | 31 | 29435848 |
Thrombocytopenia | 15.41 | 10.11 | 498 | 138150 | 134325 | 29301554 |
Purple glove syndrome | 15.35 | 10.11 | 7 | 138641 | 57 | 29435822 |
Pneumocystis jirovecii pneumonia | 15.33 | 10.11 | 35 | 138613 | 16744 | 29419135 |
Injection site swelling | 15.26 | 10.11 | 13 | 138635 | 9404 | 29426475 |
Proteinuria | 15.23 | 10.11 | 32 | 138616 | 15772 | 29420107 |
Fall | 15.20 | 10.11 | 994 | 137654 | 176184 | 29259695 |
Hypoxia | 15.16 | 10.11 | 309 | 138339 | 47070 | 29388809 |
Polyneuropathy | 15.02 | 10.11 | 21 | 138627 | 12131 | 29423748 |
Myelodysplastic syndrome | 14.77 | 10.11 | 39 | 138609 | 17755 | 29418124 |
Self esteem decreased | 14.77 | 10.11 | 15 | 138633 | 502 | 29435377 |
Testicular atrophy | 14.77 | 10.11 | 15 | 138633 | 502 | 29435377 |
Infusion related reaction | 14.74 | 10.11 | 133 | 138515 | 43753 | 29392126 |
Sleep disorder | 14.71 | 10.11 | 177 | 138471 | 24209 | 29411670 |
Blood urea nitrogen/creatinine ratio decreased | 14.70 | 10.11 | 6 | 138642 | 36 | 29435843 |
Fear | 14.46 | 10.11 | 85 | 138563 | 9419 | 29426460 |
Pressure of speech | 14.40 | 10.11 | 14 | 138634 | 444 | 29435435 |
Soliloquy | 14.33 | 10.11 | 13 | 138635 | 377 | 29435502 |
Shoshin beriberi | 14.20 | 10.11 | 7 | 138641 | 69 | 29435810 |
Myocarditis | 14.18 | 10.11 | 94 | 138554 | 10862 | 29425017 |
Emotional disorder | 14.10 | 10.11 | 53 | 138595 | 4878 | 29431001 |
Body temperature increased | 14.09 | 10.11 | 116 | 138532 | 14349 | 29421530 |
Epidural lipomatosis | 14.03 | 10.11 | 17 | 138631 | 694 | 29435185 |
Septic shock | 13.84 | 10.11 | 208 | 138440 | 62352 | 29373527 |
Gingival oedema | 13.83 | 10.11 | 4 | 138644 | 6 | 29435873 |
Coordination abnormal | 13.80 | 10.11 | 68 | 138580 | 7046 | 29428833 |
Drop attacks | 13.79 | 10.11 | 15 | 138633 | 544 | 29435335 |
Hepatocellular carcinoma | 13.66 | 10.11 | 8 | 138640 | 7030 | 29428849 |
Hepatic failure | 13.64 | 10.11 | 89 | 138559 | 31423 | 29404456 |
Renal failure | 13.57 | 10.11 | 438 | 138210 | 118161 | 29317718 |
Slow speech | 13.55 | 10.11 | 19 | 138629 | 897 | 29434982 |
Cognitive disorder | 13.50 | 10.11 | 169 | 138479 | 23330 | 29412549 |
Derealisation | 13.36 | 10.11 | 15 | 138633 | 564 | 29435315 |
Blood prolactin increased | 13.34 | 10.11 | 25 | 138623 | 1509 | 29434370 |
Immunosuppressant drug level increased | 13.32 | 10.11 | 3 | 138645 | 4762 | 29431117 |
Child abuse | 13.31 | 10.11 | 10 | 138638 | 221 | 29435658 |
Ascites | 13.18 | 10.11 | 109 | 138539 | 36510 | 29399369 |
Hepatocellular injury | 13.17 | 10.11 | 53 | 138595 | 21190 | 29414689 |
Vascular stenosis | 13.06 | 10.11 | 9 | 138639 | 173 | 29435706 |
Glycosylated haemoglobin increased | 12.99 | 10.11 | 15 | 138633 | 9411 | 29426468 |
Generalised tonic-clonic seizure | 12.92 | 10.11 | 142 | 138506 | 18997 | 29416882 |
Injection site erythema | 12.84 | 10.11 | 29 | 138619 | 13927 | 29421952 |
Pneumonia | 12.84 | 10.11 | 1310 | 137338 | 318862 | 29117017 |
Rebound effect | 12.82 | 10.11 | 29 | 138619 | 2002 | 29433877 |
Hallucination, olfactory | 12.67 | 10.11 | 9 | 138639 | 182 | 29435697 |
Rhabdomyolysis | 12.65 | 10.11 | 374 | 138274 | 60434 | 29375445 |
Congenital pulmonary valve atresia | 12.64 | 10.11 | 6 | 138642 | 54 | 29435825 |
Transient acantholytic dermatosis | 12.59 | 10.11 | 7 | 138641 | 90 | 29435789 |
Depressed mood | 12.50 | 10.11 | 125 | 138523 | 16323 | 29419556 |
Poor sucking reflex | 12.45 | 10.11 | 11 | 138637 | 308 | 29435571 |
Skin necrosis | 12.42 | 10.11 | 4 | 138644 | 5008 | 29430871 |
Dystonic tremor | 12.42 | 10.11 | 9 | 138639 | 188 | 29435691 |
Therapeutic product effect incomplete | 12.39 | 10.11 | 121 | 138527 | 39184 | 29396695 |
Hypercapnia | 12.32 | 10.11 | 42 | 138606 | 3684 | 29432195 |
COVID-19 pneumonia | 12.23 | 10.11 | 16 | 138632 | 9506 | 29426373 |
Electroencephalogram abnormal | 12.22 | 10.11 | 31 | 138617 | 2304 | 29433575 |
Accident at work | 12.10 | 10.11 | 15 | 138633 | 627 | 29435252 |
Dyspnoea exertional | 12.07 | 10.11 | 111 | 138537 | 36379 | 29399500 |
Lip swelling | 12.07 | 10.11 | 25 | 138623 | 12385 | 29423494 |
Cardiac disorder | 12.05 | 10.11 | 114 | 138534 | 37149 | 29398730 |
Feelings of worthlessness | 12.03 | 10.11 | 10 | 138638 | 257 | 29435622 |
Arachnoid cyst | 12.02 | 10.11 | 9 | 138639 | 198 | 29435681 |
Peritonitis bacterial | 11.97 | 10.11 | 6 | 138642 | 5750 | 29430129 |
Blood alkaline phosphatase decreased | 11.96 | 10.11 | 15 | 138633 | 635 | 29435244 |
Staphylococcal infection | 11.95 | 10.11 | 84 | 138564 | 29156 | 29406723 |
Chronic kidney disease | 11.95 | 10.11 | 111 | 138537 | 36305 | 29399574 |
End stage renal disease | 11.91 | 10.11 | 11 | 138637 | 7653 | 29428226 |
Progressive multifocal leukoencephalopathy | 11.88 | 10.11 | 14 | 138634 | 8705 | 29427174 |
Drooling | 11.75 | 10.11 | 36 | 138612 | 2985 | 29432894 |
Creutzfeldt-Jakob disease | 11.73 | 10.11 | 5 | 138643 | 34 | 29435845 |
Echolalia | 11.71 | 10.11 | 10 | 138638 | 267 | 29435612 |
Drug tolerance | 11.70 | 10.11 | 29 | 138619 | 2124 | 29433755 |
Waxy flexibility | 11.66 | 10.11 | 7 | 138641 | 105 | 29435774 |
Tuberculosis | 11.58 | 10.11 | 10 | 138638 | 7186 | 29428693 |
Mobility decreased | 11.58 | 10.11 | 72 | 138576 | 25708 | 29410171 |
Lung disorder | 11.56 | 10.11 | 89 | 138559 | 30273 | 29405606 |
Gastric ulcer | 11.54 | 10.11 | 31 | 138617 | 14030 | 29421849 |
Pancreatitis acute | 11.53 | 10.11 | 67 | 138581 | 24318 | 29411561 |
Pulmonary tuberculosis | 11.51 | 10.11 | 3 | 138645 | 4312 | 29431567 |
General physical health deterioration | 11.49 | 10.11 | 381 | 138267 | 102476 | 29333403 |
Ureteric obstruction | 11.45 | 10.11 | 20 | 138628 | 1143 | 29434736 |
Hepatotoxicity | 11.44 | 10.11 | 44 | 138604 | 17823 | 29418056 |
Product use issue | 11.39 | 10.11 | 171 | 138477 | 51273 | 29384606 |
Blood osmolarity increased | 11.39 | 10.11 | 11 | 138637 | 346 | 29435533 |
Tachyphrenia | 11.37 | 10.11 | 20 | 138628 | 1149 | 29434730 |
Hypertensive crisis | 11.35 | 10.11 | 12 | 138636 | 7836 | 29428043 |
Blood chloride abnormal | 11.31 | 10.11 | 4 | 138644 | 15 | 29435864 |
Selective mutism | 11.30 | 10.11 | 6 | 138642 | 70 | 29435809 |
Impaired reasoning | 11.27 | 10.11 | 7 | 138641 | 112 | 29435767 |
Nephrolithiasis | 11.25 | 10.11 | 71 | 138577 | 25263 | 29410616 |
Bronchopulmonary aspergillosis allergic | 11.24 | 10.11 | 13 | 138635 | 505 | 29435374 |
Impaired driving ability | 11.23 | 10.11 | 30 | 138618 | 2301 | 29433578 |
Cytotoxic oedema | 11.21 | 10.11 | 8 | 138640 | 163 | 29435716 |
Head injury | 11.18 | 10.11 | 120 | 138528 | 15961 | 29419918 |
Tangentiality | 11.16 | 10.11 | 7 | 138641 | 114 | 29435765 |
Respiratory acidosis | 11.14 | 10.11 | 45 | 138603 | 4283 | 29431596 |
Device issue | 11.14 | 10.11 | 12 | 138636 | 7768 | 29428111 |
Mood swings | 11.13 | 10.11 | 65 | 138583 | 7186 | 29428693 |
Neonatal tachypnoea | 11.12 | 10.11 | 8 | 138640 | 165 | 29435714 |
Bronchopulmonary aspergillosis | 11.07 | 10.11 | 26 | 138622 | 12318 | 29423561 |
Muscle mass | 11.04 | 10.11 | 9 | 138639 | 225 | 29435654 |
Thought withdrawal | 11.04 | 10.11 | 3 | 138645 | 3 | 29435876 |
Anorectal operation | 11.04 | 10.11 | 3 | 138645 | 3 | 29435876 |
Pulse pressure increased | 11.04 | 10.11 | 3 | 138645 | 3 | 29435876 |
Skin laceration | 10.93 | 10.11 | 89 | 138559 | 10973 | 29424906 |
Apnoea | 10.91 | 10.11 | 57 | 138591 | 6045 | 29429834 |
Product use in unapproved indication | 10.87 | 10.11 | 317 | 138331 | 86558 | 29349321 |
Injection site pruritus | 10.86 | 10.11 | 7 | 138641 | 5842 | 29430037 |
Foetal exposure during pregnancy | 10.78 | 10.11 | 104 | 138544 | 33763 | 29402116 |
Pharyngeal paraesthesia | 10.75 | 10.11 | 12 | 138636 | 448 | 29435431 |
Hypocalcaemia | 10.75 | 10.11 | 55 | 138593 | 20610 | 29415269 |
Blood potassium decreased | 10.74 | 10.11 | 117 | 138531 | 15617 | 29420262 |
Thrombotic microangiopathy | 10.73 | 10.11 | 15 | 138633 | 8666 | 29427213 |
Aplastic anaemia | 10.69 | 10.11 | 66 | 138582 | 7444 | 29428435 |
Iatrogenic injury | 10.68 | 10.11 | 15 | 138633 | 709 | 29435170 |
Malaise | 10.63 | 10.11 | 626 | 138022 | 158976 | 29276903 |
Dementia with Lewy bodies | 10.60 | 10.11 | 14 | 138634 | 624 | 29435255 |
Nerve degeneration | 10.49 | 10.11 | 8 | 138640 | 181 | 29435698 |
Hypomania | 10.48 | 10.11 | 28 | 138620 | 2147 | 29433732 |
Lactic acidosis | 10.45 | 10.11 | 91 | 138557 | 30156 | 29405723 |
Frequent bowel movements | 10.42 | 10.11 | 17 | 138631 | 9222 | 29426657 |
Grandiosity | 10.42 | 10.11 | 10 | 138638 | 312 | 29435567 |
Genital pain | 10.38 | 10.11 | 8 | 138640 | 184 | 29435695 |
Feeling jittery | 10.34 | 10.11 | 39 | 138609 | 3594 | 29432285 |
Mydriasis | 10.30 | 10.11 | 56 | 138592 | 6029 | 29429850 |
Blood uric acid abnormal | 10.29 | 10.11 | 6 | 138642 | 85 | 29435794 |
Emotional distress | 10.27 | 10.11 | 105 | 138543 | 13790 | 29422089 |
Acute coronary syndrome | 10.24 | 10.11 | 27 | 138621 | 12298 | 29423581 |
Venous angioma of brain | 10.24 | 10.11 | 4 | 138644 | 21 | 29435858 |
Wrong technique in product usage process | 10.22 | 10.11 | 96 | 138552 | 31332 | 29404547 |
Cerebral atrophy | 10.21 | 10.11 | 42 | 138606 | 4030 | 29431849 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Sopor | 2425.27 | 9.55 | 1610 | 311307 | 28051 | 64157764 |
Drug abuse | 1401.84 | 9.55 | 2393 | 310524 | 129981 | 64055834 |
Completed suicide | 760.05 | 9.55 | 2605 | 310312 | 221809 | 63964006 |
Intentional self-injury | 704.87 | 9.55 | 785 | 312132 | 28259 | 64157556 |
Neuroleptic malignant syndrome | 661.27 | 9.55 | 707 | 312210 | 24289 | 64161526 |
Agitation | 597.84 | 9.55 | 1323 | 311594 | 87044 | 64098771 |
Bradyphrenia | 584.92 | 9.55 | 432 | 312485 | 8974 | 64176841 |
Suicide attempt | 537.70 | 9.55 | 1113 | 311804 | 69894 | 64115921 |
Somnolence | 500.23 | 9.55 | 2135 | 310782 | 201510 | 63984305 |
Catatonia | 487.42 | 9.55 | 356 | 312561 | 7264 | 64178551 |
Delirium | 390.29 | 9.55 | 965 | 311952 | 68229 | 64117586 |
Overdose | 384.75 | 9.55 | 1664 | 311253 | 157902 | 64027913 |
Intentional overdose | 383.28 | 9.55 | 1131 | 311786 | 88813 | 64097002 |
Psychotic disorder | 297.65 | 9.55 | 572 | 312345 | 34006 | 64151809 |
Drug withdrawal syndrome | 290.95 | 9.55 | 535 | 312382 | 30756 | 64155059 |
Coma | 283.68 | 9.55 | 1003 | 311914 | 86612 | 64099203 |
Toxicity to various agents | 262.47 | 9.55 | 2806 | 310111 | 360707 | 63825108 |
Confusional state | 258.44 | 9.55 | 2156 | 310761 | 258988 | 63926827 |
Aggression | 252.47 | 9.55 | 637 | 312280 | 45595 | 64140220 |
Drug dependence | 247.17 | 9.55 | 518 | 312399 | 32794 | 64153021 |
Sedation | 235.58 | 9.55 | 580 | 312337 | 40882 | 64144933 |
Anxiety | 231.12 | 9.55 | 1729 | 311188 | 200920 | 63984895 |
Restlessness | 222.30 | 9.55 | 553 | 312364 | 39232 | 64146583 |
Suicidal ideation | 219.01 | 9.55 | 766 | 312151 | 65776 | 64120039 |
Joint swelling | 209.71 | 9.55 | 458 | 312459 | 214924 | 63970891 |
Serotonin syndrome | 203.88 | 9.55 | 531 | 312386 | 38751 | 64147064 |
Poisoning | 199.52 | 9.55 | 371 | 312546 | 21508 | 64164307 |
Disorientation | 198.94 | 9.55 | 660 | 312257 | 55168 | 64130647 |
Contraindicated product administered | 196.20 | 9.55 | 142 | 312775 | 107687 | 64078128 |
Respiratory depression | 193.45 | 9.55 | 381 | 312536 | 23062 | 64162753 |
Extrapyramidal disorder | 181.38 | 9.55 | 334 | 312583 | 19218 | 64166597 |
Tachycardia | 181.20 | 9.55 | 1295 | 311622 | 148284 | 64037531 |
Dysarthria | 178.61 | 9.55 | 664 | 312253 | 58742 | 64127073 |
Schizophrenia | 177.42 | 9.55 | 244 | 312673 | 10924 | 64174891 |
Drug intolerance | 176.25 | 9.55 | 408 | 312509 | 187584 | 63998231 |
Muscle rigidity | 170.36 | 9.55 | 305 | 312612 | 17168 | 64168647 |
Depressed level of consciousness | 168.32 | 9.55 | 812 | 312105 | 80624 | 64105191 |
Drug interaction | 167.51 | 9.55 | 2575 | 310342 | 359508 | 63826307 |
Rheumatoid arthritis | 164.34 | 9.55 | 344 | 312573 | 163950 | 64021865 |
Treatment failure | 161.79 | 9.55 | 197 | 312720 | 116619 | 64069196 |
Akathisia | 161.49 | 9.55 | 237 | 312680 | 11273 | 64174542 |
Arthropathy | 161.28 | 9.55 | 210 | 312707 | 120757 | 64065058 |
Bradykinesia | 160.29 | 9.55 | 178 | 312739 | 6382 | 64179433 |
Hallucination, auditory | 157.93 | 9.55 | 290 | 312627 | 16649 | 64169166 |
Speech disorder | 156.25 | 9.55 | 554 | 312363 | 47887 | 64137928 |
Arthralgia | 155.30 | 9.55 | 1385 | 311532 | 440875 | 63744940 |
Interstitial lung disease | 149.39 | 9.55 | 152 | 312765 | 97580 | 64088235 |
Drug ineffective | 149.34 | 9.55 | 3030 | 309887 | 837217 | 63348598 |
Psychomotor hyperactivity | 145.72 | 9.55 | 256 | 312661 | 14195 | 64171620 |
Therapeutic product effect decreased | 144.97 | 9.55 | 209 | 312708 | 115142 | 64070673 |
Synovitis | 141.60 | 9.55 | 163 | 312754 | 98927 | 64086888 |
Mental status changes | 140.48 | 9.55 | 629 | 312288 | 60533 | 64125282 |
Mania | 139.63 | 9.55 | 269 | 312648 | 16017 | 64169798 |
Abnormal behaviour | 136.68 | 9.55 | 416 | 312501 | 33206 | 64152609 |
Withdrawal syndrome | 134.88 | 9.55 | 330 | 312587 | 23162 | 64162653 |
Hypersensitivity | 134.78 | 9.55 | 494 | 312423 | 195958 | 63989857 |
Pneumonia aspiration | 132.72 | 9.55 | 605 | 312312 | 58666 | 64127149 |
Delusion | 128.84 | 9.55 | 276 | 312641 | 17738 | 64168077 |
Pemphigus | 126.90 | 9.55 | 68 | 312849 | 60633 | 64125182 |
Mydriasis | 126.51 | 9.55 | 249 | 312668 | 15063 | 64170752 |
Hand deformity | 124.52 | 9.55 | 75 | 312842 | 62696 | 64123119 |
Systemic lupus erythematosus | 121.72 | 9.55 | 118 | 312799 | 77494 | 64108321 |
Rash | 120.08 | 9.55 | 1537 | 311380 | 457012 | 63728803 |
Anti-cyclic citrullinated peptide antibody positive | 104.37 | 9.55 | 55 | 312862 | 49507 | 64136308 |
Hypokinesia | 103.78 | 9.55 | 241 | 312676 | 16355 | 64169460 |
Unresponsive to stimuli | 102.32 | 9.55 | 500 | 312417 | 49893 | 64135922 |
Psychomotor retardation | 101.39 | 9.55 | 125 | 312792 | 5018 | 64180797 |
Swelling | 100.20 | 9.55 | 418 | 312499 | 159800 | 64026015 |
Slow speech | 99.29 | 9.55 | 81 | 312836 | 1956 | 64183859 |
Infusion related reaction | 98.62 | 9.55 | 436 | 312481 | 164031 | 64021784 |
Hallucination | 98.03 | 9.55 | 647 | 312270 | 72141 | 64113674 |
Alopecia | 97.70 | 9.55 | 442 | 312475 | 165248 | 64020567 |
Seizure | 95.53 | 9.55 | 1233 | 311684 | 165659 | 64020156 |
Respiratory arrest | 95.20 | 9.55 | 508 | 312409 | 52477 | 64133338 |
Off label use | 93.06 | 9.55 | 2349 | 310568 | 630457 | 63555358 |
Tremor | 90.76 | 9.55 | 1109 | 311808 | 147121 | 64038694 |
Mobility decreased | 90.70 | 9.55 | 174 | 312743 | 85666 | 64100149 |
Electrocardiogram QT prolonged | 89.92 | 9.55 | 677 | 312240 | 78771 | 64107044 |
Drug hypersensitivity | 89.90 | 9.55 | 730 | 312187 | 237085 | 63948730 |
Paranoia | 87.88 | 9.55 | 224 | 312693 | 16128 | 64169687 |
Peripheral swelling | 86.59 | 9.55 | 626 | 312291 | 208527 | 63977288 |
Dystonia | 85.84 | 9.55 | 243 | 312674 | 18622 | 64167193 |
Stupor | 85.72 | 9.55 | 125 | 312792 | 5910 | 64179905 |
Salivary hypersecretion | 84.80 | 9.55 | 184 | 312733 | 11929 | 64173886 |
Depression | 84.72 | 9.55 | 1304 | 311613 | 181987 | 64003828 |
Granulocytopenia | 84.11 | 9.55 | 168 | 312749 | 10272 | 64175543 |
Miosis | 83.34 | 9.55 | 193 | 312724 | 13073 | 64172742 |
Cytomegalovirus infection | 83.30 | 9.55 | 38 | 312879 | 37161 | 64148654 |
COVID-19 | 82.83 | 9.55 | 117 | 312800 | 65023 | 64120792 |
Derealisation | 80.45 | 9.55 | 63 | 312854 | 1432 | 64184383 |
Parkinsonism | 79.44 | 9.55 | 199 | 312718 | 14174 | 64171641 |
Dyskinesia | 79.38 | 9.55 | 390 | 312527 | 38998 | 64146817 |
Rheumatoid factor positive | 79.32 | 9.55 | 35 | 312882 | 34903 | 64150912 |
Status epilepticus | 76.16 | 9.55 | 255 | 312662 | 21408 | 64164407 |
Hypothermia | 75.45 | 9.55 | 240 | 312677 | 19616 | 64166199 |
Mental disorder | 73.22 | 9.55 | 288 | 312629 | 26157 | 64159658 |
Febrile neutropenia | 72.67 | 9.55 | 1297 | 311620 | 186360 | 63999455 |
Injection site pain | 72.56 | 9.55 | 286 | 312631 | 111122 | 64074693 |
Hyperammonaemic encephalopathy | 71.09 | 9.55 | 93 | 312824 | 3965 | 64181850 |
Substance abuse | 70.67 | 9.55 | 146 | 312771 | 9146 | 64176669 |
Bezoar | 70.38 | 9.55 | 69 | 312848 | 2134 | 64183681 |
Psoriasis | 69.26 | 9.55 | 153 | 312764 | 71550 | 64114265 |
Renal impairment | 68.79 | 9.55 | 379 | 312538 | 134638 | 64051177 |
Glossodynia | 68.46 | 9.55 | 131 | 312786 | 64565 | 64121250 |
Drooling | 68.17 | 9.55 | 105 | 312812 | 5214 | 64180601 |
Gastric pH decreased | 67.63 | 9.55 | 43 | 312874 | 692 | 64185123 |
Mutism | 67.40 | 9.55 | 65 | 312852 | 1969 | 64183846 |
Pruritus | 67.26 | 9.55 | 1088 | 311829 | 311312 | 63874503 |
Acute kidney injury | 66.59 | 9.55 | 1665 | 311252 | 447575 | 63738240 |
Sinus tachycardia | 66.50 | 9.55 | 321 | 312596 | 31867 | 64153948 |
Infection | 65.57 | 9.55 | 577 | 312340 | 184303 | 64001512 |
Pain | 65.43 | 9.55 | 2117 | 310800 | 551394 | 63634421 |
Hepatic enzyme increased | 63.90 | 9.55 | 369 | 312548 | 129574 | 64056241 |
Injection site erythema | 63.63 | 9.55 | 157 | 312760 | 70643 | 64115172 |
Hepatic function abnormal | 63.13 | 9.55 | 136 | 312781 | 64177 | 64121638 |
Homicide | 63.01 | 9.55 | 49 | 312868 | 1102 | 64184713 |
Cardiac arrest | 62.92 | 9.55 | 1074 | 311843 | 152990 | 64032825 |
Lower respiratory tract infection | 62.82 | 9.55 | 241 | 312676 | 94373 | 64091442 |
Anaphylactic shock | 61.90 | 9.55 | 35 | 312882 | 30293 | 64155522 |
Mental impairment | 61.60 | 9.55 | 197 | 312720 | 16146 | 64169669 |
Pain in extremity | 61.50 | 9.55 | 1067 | 311850 | 302018 | 63883797 |
Abdominal discomfort | 61.18 | 9.55 | 577 | 312340 | 181745 | 64004070 |
Psoriatic arthropathy | 60.95 | 9.55 | 72 | 312845 | 43209 | 64142606 |
Maternal exposure during pregnancy | 60.02 | 9.55 | 250 | 312667 | 95634 | 64090181 |
Product dose omission issue | 59.66 | 9.55 | 630 | 312287 | 194117 | 63991698 |
Loss of consciousness | 59.41 | 9.55 | 1031 | 311886 | 147334 | 64038481 |
Pericarditis | 59.07 | 9.55 | 135 | 312782 | 62381 | 64123434 |
Persecutory delusion | 58.88 | 9.55 | 86 | 312831 | 4072 | 64181743 |
Withdrawal catatonia | 58.70 | 9.55 | 24 | 312893 | 139 | 64185676 |
Incontinence | 58.31 | 9.55 | 159 | 312758 | 11922 | 64173893 |
Feeling of despair | 58.18 | 9.55 | 67 | 312850 | 2501 | 64183314 |
Hallucinations, mixed | 58.17 | 9.55 | 105 | 312812 | 5947 | 64179868 |
Myelosuppression | 57.12 | 9.55 | 22 | 312895 | 23808 | 64162007 |
Tardive dyskinesia | 57.08 | 9.55 | 133 | 312784 | 9045 | 64176770 |
Major depression | 56.17 | 9.55 | 120 | 312797 | 7696 | 64178119 |
Dissociation | 55.87 | 9.55 | 71 | 312846 | 2940 | 64182875 |
Antipsychotic drug level increased | 54.69 | 9.55 | 93 | 312824 | 5022 | 64180793 |
Refusal of treatment by patient | 54.24 | 9.55 | 123 | 312794 | 8216 | 64177599 |
Fall | 53.89 | 9.55 | 2505 | 310412 | 414321 | 63771494 |
Sinusitis | 51.92 | 9.55 | 455 | 312462 | 145473 | 64040342 |
Depersonalisation/derealisation disorder | 51.71 | 9.55 | 51 | 312866 | 1589 | 64184226 |
Visceral congestion | 51.65 | 9.55 | 38 | 312879 | 784 | 64185031 |
Device expulsion | 51.52 | 9.55 | 19 | 312898 | 21117 | 64164698 |
Bone marrow failure | 50.82 | 9.55 | 97 | 312820 | 47855 | 64137960 |
Blister | 50.74 | 9.55 | 211 | 312706 | 80756 | 64105059 |
Drug eruption | 49.94 | 9.55 | 61 | 312856 | 36075 | 64149740 |
Ataxia | 49.85 | 9.55 | 226 | 312691 | 21858 | 64163957 |
Feeling jittery | 49.37 | 9.55 | 138 | 312779 | 10497 | 64175318 |
Hyponatraemia | 48.76 | 9.55 | 1000 | 311917 | 147339 | 64038476 |
Erythema | 48.45 | 9.55 | 628 | 312289 | 186442 | 63999373 |
Apnoea | 48.15 | 9.55 | 135 | 312782 | 10287 | 64175528 |
Disturbance in attention | 47.58 | 9.55 | 352 | 312565 | 40722 | 64145093 |
Mood swings | 47.36 | 9.55 | 189 | 312728 | 17279 | 64168536 |
Blood creatine phosphokinase increased | 47.28 | 9.55 | 463 | 312454 | 58095 | 64127720 |
Nasopharyngitis | 46.54 | 9.55 | 670 | 312247 | 195403 | 63990412 |
Skin necrosis | 46.45 | 9.55 | 7 | 312910 | 14322 | 64171493 |
Somatic symptom disorder | 46.18 | 9.55 | 51 | 312866 | 1817 | 64183998 |
Product use issue | 45.96 | 9.55 | 492 | 312425 | 151223 | 64034592 |
Emotional disorder | 45.74 | 9.55 | 150 | 312767 | 12457 | 64173358 |
Schizoaffective disorder | 45.73 | 9.55 | 47 | 312870 | 1540 | 64184275 |
C-reactive protein abnormal | 45.72 | 9.55 | 44 | 312873 | 29003 | 64156812 |
Intentional product misuse | 45.56 | 9.55 | 544 | 312373 | 71751 | 64114064 |
Hallucination, visual | 45.40 | 9.55 | 260 | 312657 | 27574 | 64158241 |
Insomnia | 45.33 | 9.55 | 1269 | 311648 | 196567 | 63989248 |
Therapeutic response decreased | 45.13 | 9.55 | 118 | 312799 | 52070 | 64133745 |
Cogwheel rigidity | 44.81 | 9.55 | 62 | 312855 | 2791 | 64183024 |
Dysphagia | 44.46 | 9.55 | 747 | 312170 | 106065 | 64079750 |
Skin ulcer | 43.98 | 9.55 | 92 | 312825 | 43882 | 64141933 |
Parosmia | 43.96 | 9.55 | 80 | 312837 | 4560 | 64181255 |
Electrocardiogram QRS complex prolonged | 43.95 | 9.55 | 121 | 312796 | 9123 | 64176692 |
Cardiac failure congestive | 43.90 | 9.55 | 413 | 312504 | 130167 | 64055648 |
Blood prolactin increased | 42.93 | 9.55 | 68 | 312849 | 3460 | 64182355 |
Red blood cell sedimentation rate increased | 42.87 | 9.55 | 53 | 312864 | 31182 | 64154633 |
Tenosynovitis | 42.76 | 9.55 | 4 | 312913 | 11829 | 64173986 |
Injection site swelling | 42.65 | 9.55 | 85 | 312832 | 41268 | 64144547 |
Lethargy | 42.61 | 9.55 | 539 | 312378 | 72055 | 64113760 |
Inflammation | 42.27 | 9.55 | 168 | 312749 | 65132 | 64120683 |
Hypoxia | 42.17 | 9.55 | 631 | 312286 | 87518 | 64098297 |
Poverty of speech | 41.51 | 9.55 | 29 | 312888 | 550 | 64185265 |
Injection site pruritus | 41.42 | 9.55 | 75 | 312842 | 37751 | 64148064 |
Cardiac failure | 41.42 | 9.55 | 426 | 312491 | 131947 | 64053868 |
Angioedema | 41.33 | 9.55 | 157 | 312760 | 61664 | 64124151 |
Coma scale abnormal | 41.26 | 9.55 | 106 | 312811 | 7668 | 64178147 |
Acute myocardial infarction | 41.05 | 9.55 | 186 | 312731 | 69532 | 64116283 |
Disorganised speech | 40.70 | 9.55 | 45 | 312872 | 1605 | 64184210 |
Myocardial infarction | 40.63 | 9.55 | 563 | 312354 | 165258 | 64020557 |
Intentional product use issue | 40.60 | 9.55 | 283 | 312634 | 95081 | 64090734 |
Cardio-respiratory arrest | 40.54 | 9.55 | 687 | 312230 | 97706 | 64088109 |
Myocardial depression | 40.34 | 9.55 | 27 | 312890 | 476 | 64185339 |
Haematotoxicity | 40.24 | 9.55 | 7 | 312910 | 12889 | 64172926 |
Knee arthroplasty | 40.10 | 9.55 | 43 | 312874 | 26956 | 64158859 |
Gastrointestinal haemorrhage | 40.10 | 9.55 | 429 | 312488 | 131883 | 64053932 |
Irritability | 39.81 | 9.55 | 310 | 312607 | 36436 | 64149379 |
Urticaria | 39.45 | 9.55 | 491 | 312426 | 146826 | 64038989 |
Wound | 39.30 | 9.55 | 214 | 312703 | 76263 | 64109552 |
Osteonecrosis of jaw | 39.26 | 9.55 | 84 | 312833 | 39741 | 64146074 |
Drug withdrawal convulsions | 39.20 | 9.55 | 50 | 312867 | 2078 | 64183737 |
Dehydration | 39.20 | 9.55 | 1351 | 311566 | 215412 | 63970403 |
Pleurothotonus | 39.16 | 9.55 | 52 | 312865 | 2250 | 64183565 |
Myocardial fibrosis | 38.82 | 9.55 | 43 | 312874 | 1537 | 64184278 |
Discomfort | 38.51 | 9.55 | 232 | 312685 | 80646 | 64105169 |
Logorrhoea | 38.48 | 9.55 | 70 | 312847 | 3989 | 64181826 |
Delusion of grandeur | 38.30 | 9.55 | 28 | 312889 | 572 | 64185243 |
Psychotic behaviour | 38.16 | 9.55 | 35 | 312882 | 994 | 64184821 |
Neutropenic sepsis | 38.11 | 9.55 | 34 | 312883 | 23238 | 64162577 |
Echolalia | 37.63 | 9.55 | 23 | 312894 | 344 | 64185471 |
Amnesia | 37.20 | 9.55 | 378 | 312539 | 47891 | 64137924 |
Anaemia | 36.99 | 9.55 | 1482 | 311435 | 377198 | 63808617 |
Bone erosion | 36.83 | 9.55 | 6 | 312911 | 11589 | 64174226 |
Drug screen positive | 36.70 | 9.55 | 84 | 312833 | 5645 | 64180170 |
Drug reaction with eosinophilia and systemic symptoms | 36.69 | 9.55 | 137 | 312780 | 54080 | 64131735 |
Incoherent | 36.69 | 9.55 | 96 | 312821 | 7022 | 64178793 |
Pathogen resistance | 36.63 | 9.55 | 8 | 312909 | 12535 | 64173280 |
Drop attacks | 36.62 | 9.55 | 34 | 312883 | 981 | 64184834 |
Negativism | 36.58 | 9.55 | 30 | 312887 | 730 | 64185085 |
Respiratory acidosis | 36.42 | 9.55 | 118 | 312799 | 9737 | 64176078 |
Sleep disorder | 36.19 | 9.55 | 446 | 312471 | 59263 | 64126552 |
Melaena | 35.79 | 9.55 | 136 | 312781 | 53412 | 64132403 |
Transplant rejection | 35.63 | 9.55 | 20 | 312897 | 17381 | 64168434 |
Enthesopathy | 35.52 | 9.55 | 3 | 312914 | 9635 | 64176180 |
Decorticate posture | 35.43 | 9.55 | 21 | 312896 | 296 | 64185519 |
Electroencephalogram abnormal | 35.25 | 9.55 | 78 | 312839 | 5125 | 64180690 |
Communication disorder | 35.24 | 9.55 | 64 | 312853 | 3642 | 64182173 |
H1N1 influenza | 35.23 | 9.55 | 49 | 312868 | 2217 | 64183598 |
Duodenal ulcer perforation | 35 | 9.55 | 72 | 312845 | 34553 | 64151262 |
Mood altered | 34.93 | 9.55 | 162 | 312755 | 15817 | 64169998 |
Malaise | 34.88 | 9.55 | 1569 | 311348 | 394678 | 63791137 |
Plasma cell myeloma | 33.70 | 9.55 | 357 | 312560 | 45718 | 64140097 |
Multiple organ dysfunction syndrome | 33.54 | 9.55 | 322 | 312595 | 101091 | 64084724 |
Osteoporosis | 33.52 | 9.55 | 99 | 312818 | 41981 | 64143834 |
Accidental exposure to product by child | 33.18 | 9.55 | 50 | 312867 | 2435 | 64183380 |
Panic attack | 33.05 | 9.55 | 194 | 312723 | 20759 | 64165056 |
Victim of child abuse | 33.03 | 9.55 | 30 | 312887 | 841 | 64184974 |
Victim of sexual abuse | 33.01 | 9.55 | 22 | 312895 | 385 | 64185430 |
Drug resistance | 32.99 | 9.55 | 76 | 312841 | 35026 | 64150789 |
Psychotic symptom | 32.89 | 9.55 | 46 | 312871 | 2092 | 64183723 |
Pneumocystis jirovecii pneumonia | 32.83 | 9.55 | 52 | 312865 | 27582 | 64158233 |
Therapeutic product effect incomplete | 32.79 | 9.55 | 332 | 312585 | 103150 | 64082665 |
Failure to thrive | 32.69 | 9.55 | 118 | 312799 | 10286 | 64175529 |
Aspiration | 32.47 | 9.55 | 165 | 312752 | 16720 | 64169095 |
Hyperreflexia | 32.45 | 9.55 | 92 | 312825 | 7056 | 64178759 |
C-reactive protein increased | 32.40 | 9.55 | 299 | 312618 | 94610 | 64091205 |
Haemophagocytic lymphohistiocytosis | 32.26 | 9.55 | 23 | 312894 | 17586 | 64168229 |
Needle fatigue | 32.12 | 9.55 | 25 | 312892 | 563 | 64185252 |
Blood sodium decreased | 32.09 | 9.55 | 249 | 312668 | 29233 | 64156582 |
Pneumonia viral | 31.99 | 9.55 | 97 | 312820 | 7725 | 64178090 |
Inappropriate antidiuretic hormone secretion | 31.75 | 9.55 | 201 | 312716 | 22088 | 64163727 |
Sleep disorder due to general medical condition, insomnia type | 31.62 | 9.55 | 49 | 312868 | 26221 | 64159594 |
Helicobacter infection | 31.47 | 9.55 | 89 | 312828 | 38273 | 64147542 |
Basal cell carcinoma | 31.28 | 9.55 | 64 | 312853 | 30774 | 64155041 |
Myoclonus | 31.25 | 9.55 | 219 | 312698 | 24899 | 64160916 |
Affective disorder | 31.16 | 9.55 | 86 | 312831 | 6494 | 64179321 |
Blood pH decreased | 30.96 | 9.55 | 67 | 312850 | 4335 | 64181480 |
Injection site reaction | 30.88 | 9.55 | 119 | 312798 | 46545 | 64139270 |
Dyspnoea | 30.80 | 9.55 | 3036 | 309881 | 715638 | 63470177 |
Soft tissue disorder | 30.43 | 9.55 | 56 | 312861 | 3220 | 64182595 |
Sexually inappropriate behaviour | 30.23 | 9.55 | 22 | 312895 | 446 | 64185369 |
Coronary artery disease | 30.02 | 9.55 | 171 | 312746 | 60262 | 64125553 |
Liver disorder | 29.83 | 9.55 | 145 | 312772 | 53206 | 64132609 |
Nervousness | 29.65 | 9.55 | 245 | 312672 | 29311 | 64156504 |
Brain injury | 29.61 | 9.55 | 111 | 312806 | 9854 | 64175961 |
Hip arthroplasty | 29.55 | 9.55 | 36 | 312881 | 21315 | 64164500 |
Arthritis | 29.50 | 9.55 | 262 | 312655 | 83552 | 64102263 |
Homicidal ideation | 29.40 | 9.55 | 55 | 312862 | 3202 | 64182613 |
Febrile bone marrow aplasia | 29.38 | 9.55 | 9 | 312908 | 11246 | 64174569 |
Generalised tonic-clonic seizure | 29.23 | 9.55 | 309 | 312608 | 39548 | 64146267 |
Behaviour disorder | 29.23 | 9.55 | 66 | 312851 | 4396 | 64181419 |
Pancreatic fibrosis | 29.16 | 9.55 | 13 | 312904 | 96 | 64185719 |
Narcotic bowel syndrome | 28.85 | 9.55 | 17 | 312900 | 237 | 64185578 |
Staring | 28.70 | 9.55 | 46 | 312871 | 2364 | 64183451 |
Hypoglycaemia | 28.65 | 9.55 | 288 | 312629 | 89604 | 64096211 |
Gait spastic | 28.61 | 9.55 | 28 | 312889 | 864 | 64184951 |
Acute psychosis | 28.59 | 9.55 | 59 | 312858 | 3693 | 64182122 |
Oropharyngeal spasm | 28.36 | 9.55 | 17 | 312900 | 245 | 64185570 |
Urinary incontinence | 28.29 | 9.55 | 284 | 312633 | 35867 | 64149948 |
Hyperkalaemia | 28.23 | 9.55 | 334 | 312583 | 100795 | 64085020 |
Tubulointerstitial nephritis | 28.19 | 9.55 | 68 | 312849 | 30841 | 64154974 |
Injection site bruising | 27.95 | 9.55 | 87 | 312830 | 36286 | 64149529 |
Parkinsonian gait | 27.89 | 9.55 | 27 | 312890 | 822 | 64184993 |
Red blood cell sedimentation rate abnormal | 27.70 | 9.55 | 23 | 312894 | 16283 | 64169532 |
Alcohol abuse | 27.68 | 9.55 | 68 | 312849 | 4784 | 64181031 |
Suicidal behaviour | 27.63 | 9.55 | 50 | 312867 | 2837 | 64182978 |
Diabetes insipidus | 27.55 | 9.55 | 65 | 312852 | 4456 | 64181359 |
Treatment noncompliance | 27.31 | 9.55 | 327 | 312590 | 43155 | 64142660 |
Hepatocellular injury | 27.03 | 9.55 | 120 | 312797 | 45115 | 64140700 |
Nicotine dependence | 26.95 | 9.55 | 26 | 312891 | 788 | 64185027 |
Hyperhidrosis | 26.85 | 9.55 | 795 | 312122 | 124125 | 64061690 |
Anaphylactic reaction | 26.72 | 9.55 | 209 | 312708 | 68455 | 64117360 |
Alcohol interaction | 26.52 | 9.55 | 63 | 312854 | 4338 | 64181477 |
Myelodysplastic syndrome | 26.50 | 9.55 | 59 | 312858 | 27520 | 64158295 |
Impaired driving ability | 26.31 | 9.55 | 65 | 312852 | 4589 | 64181226 |
Pneumonia | 26.19 | 9.55 | 2348 | 310569 | 557228 | 63628587 |
Confabulation | 26.13 | 9.55 | 20 | 312897 | 439 | 64185376 |
Mouth ulceration | 26.08 | 9.55 | 76 | 312841 | 32368 | 64153447 |
Kidney transplant rejection | 25.94 | 9.55 | 7 | 312910 | 9504 | 64176311 |
Obsessive-compulsive disorder | 25.89 | 9.55 | 66 | 312851 | 4752 | 64181063 |
Menstrual disorder | 25.74 | 9.55 | 53 | 312864 | 3312 | 64182503 |
Prostate cancer | 25.71 | 9.55 | 35 | 312882 | 19760 | 64166055 |
Balance disorder | 25.68 | 9.55 | 560 | 312357 | 83366 | 64102449 |
Drug screen false positive | 25.66 | 9.55 | 28 | 312889 | 984 | 64184831 |
Cholestasis | 25.65 | 9.55 | 121 | 312796 | 44751 | 64141064 |
Crying | 25.49 | 9.55 | 176 | 312741 | 19914 | 64165901 |
Antipsychotic drug level decreased | 25.48 | 9.55 | 27 | 312890 | 917 | 64184898 |
Haematuria | 25.47 | 9.55 | 180 | 312737 | 60291 | 64125524 |
Macrocytosis | 25.45 | 9.55 | 44 | 312873 | 2408 | 64183407 |
Computerised tomogram thorax abnormal | 25.42 | 9.55 | 39 | 312878 | 1930 | 64183885 |
Restless legs syndrome | 25.41 | 9.55 | 156 | 312761 | 16960 | 64168855 |
Headache | 25.31 | 9.55 | 2218 | 310699 | 527249 | 63658566 |
Self-injurious ideation | 25.22 | 9.55 | 51 | 312866 | 3146 | 64182669 |
Alcohol withdrawal syndrome | 25.11 | 9.55 | 37 | 312880 | 1766 | 64184049 |
Wrong patient received product | 25.04 | 9.55 | 56 | 312861 | 3706 | 64182109 |
Urinary retention | 25.02 | 9.55 | 356 | 312561 | 48845 | 64136970 |
Galactorrhoea | 24.98 | 9.55 | 51 | 312866 | 3168 | 64182647 |
Rhinitis perennial | 24.91 | 9.55 | 15 | 312902 | 218 | 64185597 |
Foot deformity | 24.83 | 9.55 | 26 | 312891 | 16478 | 64169337 |
Anger | 24.35 | 9.55 | 145 | 312772 | 15596 | 64170219 |
Hyperprolactinaemia | 24.29 | 9.55 | 58 | 312859 | 4007 | 64181808 |
Social avoidant behaviour | 24.04 | 9.55 | 62 | 312855 | 4495 | 64181320 |
Psychiatric decompensation | 24.01 | 9.55 | 43 | 312874 | 2420 | 64183395 |
Ulcer | 23.93 | 9.55 | 47 | 312870 | 22943 | 64162872 |
Encephalitis autoimmune | 23.88 | 9.55 | 37 | 312880 | 1847 | 64183968 |
Cough | 23.86 | 9.55 | 1210 | 311707 | 300938 | 63884877 |
Cerebral infarction | 23.86 | 9.55 | 110 | 312807 | 40934 | 64144881 |
Head injury | 23.80 | 9.55 | 254 | 312663 | 32588 | 64153227 |
Oedema peripheral | 23.65 | 9.55 | 809 | 312108 | 209508 | 63976307 |
Hepatic cytolysis | 23.64 | 9.55 | 20 | 312897 | 14029 | 64171786 |
Movement disorder | 23.50 | 9.55 | 185 | 312732 | 21815 | 64164000 |
Oral discharge | 23.40 | 9.55 | 15 | 312902 | 245 | 64185570 |
Emotional distress | 23.06 | 9.55 | 272 | 312645 | 35766 | 64150049 |
Illusion | 23.00 | 9.55 | 33 | 312884 | 1537 | 64184278 |
Device issue | 22.97 | 9.55 | 47 | 312870 | 22601 | 64163214 |
Hyperchloraemia | 22.95 | 9.55 | 26 | 312891 | 953 | 64184862 |
Gastrointestinal disorder | 22.89 | 9.55 | 302 | 312615 | 89407 | 64096408 |
Cataract | 22.87 | 9.55 | 150 | 312767 | 51112 | 64134703 |
Impulsive behaviour | 22.84 | 9.55 | 44 | 312873 | 2619 | 64183196 |
Live birth | 22.76 | 9.55 | 13 | 312904 | 11191 | 64174624 |
Pressure of speech | 22.48 | 9.55 | 26 | 312891 | 975 | 64184840 |
Pulmonary tuberculosis | 22.45 | 9.55 | 4 | 312913 | 7240 | 64178575 |
Transplant dysfunction | 22.39 | 9.55 | 3 | 312914 | 6705 | 64179110 |
Bipolar disorder | 22.37 | 9.55 | 78 | 312839 | 6683 | 64179132 |
Visual acuity reduced | 22.24 | 9.55 | 63 | 312854 | 27078 | 64158737 |
Atelectasis | 22.21 | 9.55 | 216 | 312701 | 27050 | 64158765 |
Encephalopathy | 22.19 | 9.55 | 405 | 312512 | 58414 | 64127401 |
Depressed mood | 22.18 | 9.55 | 300 | 312617 | 40712 | 64145103 |
Cerebral microhaemorrhage | 22.01 | 9.55 | 13 | 312904 | 182 | 64185633 |
Relapsing-remitting multiple sclerosis | 21.95 | 9.55 | 27 | 312890 | 1081 | 64184734 |
Coma scale | 21.89 | 9.55 | 9 | 312908 | 53 | 64185762 |
Morbid thoughts | 21.83 | 9.55 | 22 | 312895 | 704 | 64185111 |
Accidental overdose | 21.79 | 9.55 | 254 | 312663 | 33303 | 64152512 |
Impaired healing | 21.74 | 9.55 | 188 | 312729 | 60285 | 64125530 |
Adverse event | 21.69 | 9.55 | 108 | 312809 | 39381 | 64146434 |
Forced expiratory volume | 21.64 | 9.55 | 10 | 312907 | 81 | 64185734 |
Panniculitis | 21.61 | 9.55 | 8 | 312909 | 8871 | 64176944 |
Orgasmic sensation decreased | 21.38 | 9.55 | 8 | 312909 | 35 | 64185780 |
Wrong technique in product usage process | 21.19 | 9.55 | 207 | 312710 | 64767 | 64121048 |
Dyspnoea exertional | 21.16 | 9.55 | 242 | 312675 | 73488 | 64112327 |
Rapid eye movements sleep abnormal | 21.11 | 9.55 | 14 | 312903 | 243 | 64185572 |
Angina pectoris | 21.10 | 9.55 | 130 | 312787 | 44951 | 64140864 |
Condition aggravated | 21.03 | 9.55 | 1539 | 311378 | 370887 | 63814928 |
Renal disorder | 21.02 | 9.55 | 94 | 312823 | 35271 | 64150544 |
Atrial fibrillation | 20.92 | 9.55 | 651 | 312266 | 170438 | 64015377 |
Hyperthyroidism | 20.85 | 9.55 | 35 | 312882 | 18144 | 64167671 |
Diarrhoea | 20.83 | 9.55 | 3133 | 309784 | 719571 | 63466244 |
Small intestinal obstruction | 20.82 | 9.55 | 190 | 312727 | 23383 | 64162432 |
Waxy flexibility | 20.72 | 9.55 | 14 | 312903 | 251 | 64185564 |
Premature ejaculation | 20.71 | 9.55 | 9 | 312908 | 62 | 64185753 |
Hypercapnia | 20.66 | 9.55 | 83 | 312834 | 7611 | 64178204 |
Tendonitis | 20.65 | 9.55 | 42 | 312875 | 20240 | 64165575 |
Patient uncooperative | 20.47 | 9.55 | 19 | 312898 | 548 | 64185267 |
Oedema | 20.46 | 9.55 | 318 | 312599 | 91617 | 64094198 |
Immunodeficiency | 20.45 | 9.55 | 29 | 312888 | 16095 | 64169720 |
Self-medication | 20.45 | 9.55 | 55 | 312862 | 4090 | 64181725 |
Disinhibition | 20.40 | 9.55 | 38 | 312879 | 2205 | 64183610 |
Neurosensory hypoacusis | 20.35 | 9.55 | 13 | 312904 | 211 | 64185604 |
Loss of personal independence in daily activities | 20.33 | 9.55 | 239 | 312678 | 72215 | 64113600 |
Hyperosmolar state | 20.28 | 9.55 | 20 | 312897 | 623 | 64185192 |
Skin maceration | 20.21 | 9.55 | 8 | 312909 | 42 | 64185773 |
Solar urticaria | 20.12 | 9.55 | 9 | 312908 | 67 | 64185748 |
Hypochloraemia | 20.12 | 9.55 | 36 | 312881 | 2025 | 64183790 |
PCO2 increased | 20.10 | 9.55 | 32 | 312885 | 1635 | 64184180 |
Musculoskeletal stiffness | 20.02 | 9.55 | 450 | 312467 | 122756 | 64063059 |
Pulmonary fibrosis | 19.89 | 9.55 | 76 | 312841 | 29802 | 64156013 |
Parathyroid gland enlargement | 19.88 | 9.55 | 11 | 312906 | 135 | 64185680 |
Testicular atrophy | 19.69 | 9.55 | 15 | 312902 | 327 | 64185488 |
Altered state of consciousness | 19.58 | 9.55 | 275 | 312642 | 37627 | 64148188 |
Polyneuropathy | 19.58 | 9.55 | 42 | 312875 | 19852 | 64165963 |
Epstein-Barr virus infection | 19.56 | 9.55 | 19 | 312898 | 12469 | 64173346 |
Mitochondrial encephalomyopathy | 19.40 | 9.55 | 7 | 312910 | 27 | 64185788 |
Diet refusal | 19.32 | 9.55 | 22 | 312895 | 811 | 64185004 |
Drug use disorder | 19.31 | 9.55 | 69 | 312848 | 5985 | 64179830 |
Drug abuser | 19.21 | 9.55 | 67 | 312850 | 5741 | 64180074 |
Bradycardia | 19.19 | 9.55 | 728 | 312189 | 117491 | 64068324 |
Acute generalised exanthematous pustulosis | 19.14 | 9.55 | 24 | 312893 | 14034 | 64171781 |
Ill-defined disorder | 19.10 | 9.55 | 130 | 312787 | 43922 | 64141893 |
Feeling of body temperature change | 19.03 | 9.55 | 59 | 312858 | 4755 | 64181060 |
Bronchopulmonary aspergillosis | 19.02 | 9.55 | 40 | 312877 | 19045 | 64166770 |
Tachypnoea | 19.02 | 9.55 | 205 | 312712 | 26366 | 64159449 |
Device difficult to use | 19.02 | 9.55 | 12 | 312905 | 9786 | 64176029 |
Cognitive disorder | 18.96 | 9.55 | 374 | 312543 | 54713 | 64131102 |
Muscle disorder | 18.95 | 9.55 | 60 | 312857 | 4891 | 64180924 |
Feelings of worthlessness | 18.94 | 9.55 | 17 | 312900 | 469 | 64185346 |
Chronic obstructive pulmonary disease | 18.93 | 9.55 | 465 | 312452 | 70583 | 64115232 |
Priapism | 18.91 | 9.55 | 52 | 312865 | 3918 | 64181897 |
Medication error | 18.83 | 9.55 | 344 | 312573 | 49622 | 64136193 |
Affect lability | 18.82 | 9.55 | 90 | 312827 | 8900 | 64176915 |
Renal failure | 18.80 | 9.55 | 706 | 312211 | 180982 | 64004833 |
Gastric ulcer | 18.80 | 9.55 | 79 | 312838 | 30155 | 64155660 |
Hypophagia | 18.78 | 9.55 | 283 | 312634 | 39304 | 64146511 |
Metabolic encephalopathy | 18.77 | 9.55 | 83 | 312834 | 7942 | 64177873 |
Polyarthritis | 18.72 | 9.55 | 12 | 312905 | 9703 | 64176112 |
Osteonecrosis | 18.67 | 9.55 | 72 | 312845 | 28157 | 64157658 |
Tachyphrenia | 18.61 | 9.55 | 33 | 312884 | 1843 | 64183972 |
Rheumatic fever | 18.57 | 9.55 | 11 | 312906 | 9283 | 64176532 |
Coronary artery bypass | 18.49 | 9.55 | 3 | 312914 | 5812 | 64180003 |
Monocyte count decreased | 18.42 | 9.55 | 42 | 312875 | 2815 | 64183000 |
Aspergillus infection | 18.36 | 9.55 | 32 | 312885 | 16347 | 64169468 |
Electrocardiogram J wave | 18.30 | 9.55 | 8 | 312909 | 56 | 64185759 |
Hangover | 18.29 | 9.55 | 33 | 312884 | 1868 | 64183947 |
Unintentional medical device removal | 18.29 | 9.55 | 5 | 312912 | 6729 | 64179086 |
Cytomegalovirus infection reactivation | 18.23 | 9.55 | 3 | 312914 | 5753 | 64180062 |
Loose associations | 18.18 | 9.55 | 8 | 312909 | 57 | 64185758 |
Acute coronary syndrome | 17.99 | 9.55 | 42 | 312875 | 19268 | 64166547 |
Rhesus antigen positive | 17.98 | 9.55 | 10 | 312907 | 124 | 64185691 |
Gait disturbance | 17.76 | 9.55 | 1013 | 311904 | 171142 | 64014673 |
Coronary artery stenosis | 17.75 | 9.55 | 17 | 312900 | 11231 | 64174584 |
Poisoning deliberate | 17.73 | 9.55 | 119 | 312798 | 13339 | 64172476 |
Hypomania | 17.66 | 9.55 | 64 | 312853 | 5590 | 64180225 |
Phagophobia | 17.65 | 9.55 | 7 | 312910 | 37 | 64185778 |
Drug screen negative | 17.64 | 9.55 | 13 | 312904 | 269 | 64185546 |
Autonomic nervous system imbalance | 17.61 | 9.55 | 52 | 312865 | 4080 | 64181735 |
Hypertonia | 17.60 | 9.55 | 69 | 312848 | 6256 | 64179559 |
Leukocytosis | 17.59 | 9.55 | 269 | 312648 | 37471 | 64148344 |
Thinking abnormal | 17.58 | 9.55 | 106 | 312811 | 11450 | 64174365 |
Cerebral atrophy | 17.53 | 9.55 | 76 | 312841 | 7209 | 64178606 |
Prescribed overdose | 17.52 | 9.55 | 163 | 312754 | 20168 | 64165647 |
Cytomegalovirus viraemia | 17.51 | 9.55 | 16 | 312901 | 10812 | 64175003 |
BK virus infection | 17.51 | 9.55 | 7 | 312910 | 7405 | 64178410 |
Cerebrovascular accident | 17.43 | 9.55 | 521 | 312396 | 137062 | 64048753 |
Irritable bowel syndrome | 17.36 | 9.55 | 108 | 312809 | 37261 | 64148554 |
Faecaloma | 17.28 | 9.55 | 93 | 312824 | 9635 | 64176180 |
Immune reconstitution inflammatory syndrome | 17.28 | 9.55 | 21 | 312896 | 12449 | 64173366 |
Wrong drug | 17.25 | 9.55 | 12 | 312905 | 226 | 64185589 |
Mucormycosis | 17.23 | 9.55 | 7 | 312910 | 7334 | 64178481 |
Impaired quality of life | 17.21 | 9.55 | 5 | 312912 | 6466 | 64179349 |
Device use error | 17.21 | 9.55 | 5 | 312912 | 6466 | 64179349 |
Haematuria traumatic | 17.20 | 9.55 | 11 | 312906 | 179 | 64185636 |
Coordination abnormal | 17.19 | 9.55 | 128 | 312789 | 14836 | 64170979 |
Tuberculosis | 16.99 | 9.55 | 23 | 312894 | 13015 | 64172800 |
Blood creatine phosphokinase | 16.88 | 9.55 | 9 | 312908 | 102 | 64185713 |
Protein C increased | 16.88 | 9.55 | 9 | 312908 | 102 | 64185713 |
Thrombosis | 16.88 | 9.55 | 241 | 312676 | 70401 | 64115414 |
Anxiolytic therapy | 16.86 | 9.55 | 6 | 312911 | 22 | 64185793 |
Drug therapy enhancement | 16.86 | 9.55 | 6 | 312911 | 22 | 64185793 |
Joint injury | 16.85 | 9.55 | 56 | 312861 | 22891 | 64162924 |
Bladder cancer | 16.84 | 9.55 | 17 | 312900 | 10957 | 64174858 |
Hepatocellular carcinoma | 16.72 | 9.55 | 10 | 312907 | 8393 | 64177422 |
Device malfunction | 16.71 | 9.55 | 38 | 312879 | 17595 | 64168220 |
Abortion spontaneous | 16.71 | 9.55 | 64 | 312853 | 25079 | 64160736 |
Dementia | 16.66 | 9.55 | 164 | 312753 | 20602 | 64165213 |
Monoparesis | 16.61 | 9.55 | 41 | 312876 | 2893 | 64182922 |
Screaming | 16.59 | 9.55 | 46 | 312871 | 3483 | 64182332 |
Computerised tomogram thorax | 16.57 | 9.55 | 10 | 312907 | 146 | 64185669 |
Endophthalmitis | 16.55 | 9.55 | 3 | 312914 | 5362 | 64180453 |
Abulia | 16.52 | 9.55 | 21 | 312896 | 870 | 64184945 |
Erysipelas | 16.45 | 9.55 | 12 | 312905 | 9069 | 64176746 |
Paradoxical drug reaction | 16.41 | 9.55 | 66 | 312851 | 6054 | 64179761 |
Micturition urgency | 16.39 | 9.55 | 96 | 312821 | 10263 | 64175552 |
Herpes zoster | 16.27 | 9.55 | 278 | 312639 | 78909 | 64106906 |
Infective pulmonary exacerbation of cystic fibrosis | 16.20 | 9.55 | 20 | 312897 | 11776 | 64174039 |
Thrombocytopenia | 16.20 | 9.55 | 904 | 312013 | 222897 | 63962918 |
Soliloquy | 16.15 | 9.55 | 17 | 312900 | 573 | 64185242 |
Oral pain | 16.07 | 9.55 | 204 | 312713 | 27289 | 64158526 |
Attention deficit hyperactivity disorder | 15.99 | 9.55 | 39 | 312878 | 2731 | 64183084 |
Skin toxicity | 15.98 | 9.55 | 6 | 312911 | 6596 | 64179219 |
Dermatitis exfoliative | 15.92 | 9.55 | 16 | 312901 | 10336 | 64175479 |
Posturing | 15.91 | 9.55 | 22 | 312895 | 990 | 64184825 |
Respiratory rate decreased | 15.90 | 9.55 | 53 | 312864 | 4438 | 64181377 |
Fluid retention | 15.82 | 9.55 | 199 | 312718 | 59407 | 64126408 |
PO2 increased | 15.78 | 9.55 | 27 | 312890 | 1465 | 64184350 |
Child abuse | 15.73 | 9.55 | 11 | 312906 | 209 | 64185606 |
Thrombotic microangiopathy | 15.70 | 9.55 | 36 | 312881 | 16619 | 64169196 |
Diabetes mellitus inadequate control | 15.68 | 9.55 | 52 | 312865 | 21269 | 64164546 |
Fear | 15.56 | 9.55 | 158 | 312759 | 20013 | 64165802 |
Joint effusion | 15.40 | 9.55 | 26 | 312891 | 13447 | 64172368 |
Rhabdomyolysis | 15.40 | 9.55 | 567 | 312350 | 91159 | 64094656 |
Blood bicarbonate decreased | 15.37 | 9.55 | 55 | 312862 | 4774 | 64181041 |
Sexual relationship change | 15.33 | 9.55 | 5 | 312912 | 13 | 64185802 |
Neologism | 15.33 | 9.55 | 5 | 312912 | 13 | 64185802 |
Muscle injury | 15.28 | 9.55 | 71 | 312846 | 26366 | 64159449 |
Shock haemorrhagic | 15.26 | 9.55 | 37 | 312880 | 16754 | 64169061 |
Pyrexia | 15.26 | 9.55 | 2429 | 310488 | 556215 | 63629600 |
Diaphragmatic rupture | 15.24 | 9.55 | 11 | 312906 | 220 | 64185595 |
Muscle mass | 15.22 | 9.55 | 14 | 312903 | 399 | 64185416 |
Gout | 15.22 | 9.55 | 53 | 312864 | 21360 | 64164455 |
End stage renal disease | 15.21 | 9.55 | 17 | 312900 | 10458 | 64175357 |
Hallucination, tactile | 15.19 | 9.55 | 15 | 312902 | 468 | 64185347 |
Femur fracture | 15.17 | 9.55 | 100 | 312817 | 34035 | 64151780 |
Nasal congestion | 15.16 | 9.55 | 201 | 312716 | 59457 | 64126358 |
Growth hormone deficiency | 15.13 | 9.55 | 13 | 312904 | 338 | 64185477 |
Respiratory distress | 15.01 | 9.55 | 346 | 312571 | 51985 | 64133830 |
Folliculitis | 14.99 | 9.55 | 85 | 312832 | 29992 | 64155823 |
Dermatitis exfoliative generalised | 14.97 | 9.55 | 5 | 312912 | 5911 | 64179904 |
Grip strength decreased | 14.96 | 9.55 | 21 | 312896 | 11703 | 64174112 |
Sacroiliitis | 14.89 | 9.55 | 40 | 312877 | 2972 | 64182843 |
Dysphoria | 14.85 | 9.55 | 51 | 312866 | 4337 | 64181478 |
Laryngitis | 14.84 | 9.55 | 19 | 312898 | 11012 | 64174803 |
Upper respiratory tract infection | 14.80 | 9.55 | 256 | 312661 | 72529 | 64113286 |
Chronic kidney disease | 14.77 | 9.55 | 195 | 312722 | 57724 | 64128091 |
Renal ischaemia | 14.76 | 9.55 | 22 | 312895 | 1061 | 64184754 |
Arthritis bacterial | 14.67 | 9.55 | 10 | 312907 | 7829 | 64177986 |
Respiratory failure | 14.66 | 9.55 | 938 | 311979 | 160245 | 64025570 |
Pulseless electrical activity | 14.65 | 9.55 | 109 | 312808 | 12630 | 64173185 |
Ear infection | 14.65 | 9.55 | 61 | 312856 | 23343 | 64162472 |
Focal dyscognitive seizures | 14.60 | 9.55 | 42 | 312875 | 3248 | 64182567 |
Nightmare | 14.58 | 9.55 | 161 | 312756 | 20832 | 64164983 |
Morose | 14.50 | 9.55 | 6 | 312911 | 36 | 64185779 |
Water intoxication | 14.42 | 9.55 | 18 | 312899 | 732 | 64185083 |
Carbohydrate antigen 125 increased | 14.32 | 9.55 | 30 | 312887 | 1898 | 64183917 |
Bronchitis | 14.22 | 9.55 | 410 | 312507 | 108333 | 64077482 |
Toxic skin eruption | 14.20 | 9.55 | 47 | 312870 | 19237 | 64166578 |
Myositis | 14.18 | 9.55 | 37 | 312880 | 16340 | 64169475 |
Cellulitis | 14.12 | 9.55 | 346 | 312571 | 93311 | 64092504 |
Glaucoma | 14.10 | 9.55 | 37 | 312880 | 16311 | 64169504 |
Coronary arterial stent insertion | 14.07 | 9.55 | 5 | 312912 | 5687 | 64180128 |
Acute graft versus host disease | 14.02 | 9.55 | 14 | 312903 | 9070 | 64176745 |
Shoshin beriberi | 13.97 | 9.55 | 7 | 312910 | 69 | 64185746 |
Gastric cancer | 13.97 | 9.55 | 7 | 312910 | 6486 | 64179329 |
Gallbladder disorder | 13.91 | 9.55 | 135 | 312782 | 16895 | 64168920 |
Hypervigilance | 13.89 | 9.55 | 14 | 312903 | 448 | 64185367 |
Schizophreniform disorder | 13.88 | 9.55 | 9 | 312908 | 150 | 64185665 |
Oculogyric crisis | 13.88 | 9.55 | 35 | 312882 | 2503 | 64183312 |
Finger deformity | 13.81 | 9.55 | 4 | 312913 | 5182 | 64180633 |
Device adhesion issue | 13.81 | 9.55 | 4 | 312913 | 5182 | 64180633 |
Myopathy | 13.79 | 9.55 | 42 | 312875 | 17638 | 64168177 |
Osteoarthritis | 13.78 | 9.55 | 220 | 312697 | 63116 | 64122699 |
Enuresis | 13.74 | 9.55 | 37 | 312880 | 2753 | 64183062 |
Platelet production decreased | 13.70 | 9.55 | 4 | 312913 | 6 | 64185809 |
Exposure during pregnancy | 13.69 | 9.55 | 280 | 312637 | 77395 | 64108420 |
Drug specific antibody present | 13.67 | 9.55 | 4 | 312913 | 5150 | 64180665 |
Rash pruritic | 13.65 | 9.55 | 196 | 312721 | 57208 | 64128607 |
Bundle branch block right | 13.65 | 9.55 | 91 | 312826 | 10178 | 64175637 |
Vasoconstriction | 13.58 | 9.55 | 16 | 312901 | 612 | 64185203 |
Clumsiness | 13.57 | 9.55 | 36 | 312881 | 2655 | 64183160 |
Sneezing | 13.56 | 9.55 | 34 | 312883 | 15217 | 64170598 |
Sluggishness | 13.53 | 9.55 | 59 | 312858 | 5611 | 64180204 |
Lung disorder | 13.49 | 9.55 | 210 | 312707 | 60490 | 64125325 |
Proteinuria | 13.47 | 9.55 | 79 | 312838 | 27644 | 64158171 |
Blood albumin increased | 13.45 | 9.55 | 24 | 312893 | 1347 | 64184468 |
Suspected suicide attempt | 13.40 | 9.55 | 11 | 312906 | 268 | 64185547 |
Mean cell haemoglobin increased | 13.37 | 9.55 | 40 | 312877 | 3162 | 64182653 |
Bradypnoea | 13.33 | 9.55 | 55 | 312862 | 5104 | 64180711 |
Benzodiazepine drug level increased | 13.32 | 9.55 | 10 | 312907 | 213 | 64185602 |
Therapy interrupted | 13.31 | 9.55 | 51 | 312866 | 19985 | 64165830 |
Delusional perception | 13.28 | 9.55 | 12 | 312905 | 334 | 64185481 |
Grandiosity | 13.24 | 9.55 | 15 | 312902 | 550 | 64185265 |
Uveitis | 13.21 | 9.55 | 26 | 312891 | 12682 | 64173133 |
Eosinophilic pneumonia | 13.20 | 9.55 | 3 | 312914 | 4574 | 64181241 |
Coeliac disease | 13.16 | 9.55 | 10 | 312907 | 7402 | 64178413 |
Dependence | 13.15 | 9.55 | 31 | 312886 | 2124 | 64183691 |
Foreign body aspiration | 13.10 | 9.55 | 11 | 312906 | 277 | 64185538 |
Thymus disorder | 13.08 | 9.55 | 10 | 312907 | 219 | 64185596 |
Nephrolithiasis | 13.08 | 9.55 | 142 | 312775 | 43541 | 64142274 |
Soft tissue swelling | 13.08 | 9.55 | 21 | 312896 | 1081 | 64184734 |
Lupus-like syndrome | 13.06 | 9.55 | 14 | 312903 | 8777 | 64177038 |
Self esteem decreased | 13.03 | 9.55 | 19 | 312898 | 898 | 64184917 |
Prostate tenderness | 13 | 9.55 | 3 | 312914 | 0 | 64185815 |
Therapeutic product ineffective | 12.98 | 9.55 | 25 | 312892 | 1488 | 64184327 |
Vomiting | 12.95 | 9.55 | 2940 | 309977 | 548177 | 63637638 |
Blunted affect | 12.92 | 9.55 | 13 | 312904 | 415 | 64185400 |
Blood creatinine increased | 12.87 | 9.55 | 533 | 312384 | 135249 | 64050566 |
Swollen joint count increased | 12.87 | 9.55 | 11 | 312906 | 7678 | 64178137 |
Surgery | 12.87 | 9.55 | 82 | 312835 | 28131 | 64157684 |
Vulvar basal cell carcinoma | 12.83 | 9.55 | 5 | 312912 | 25 | 64185790 |
Dysmetropsia | 12.79 | 9.55 | 7 | 312910 | 84 | 64185731 |
Stereotypy | 12.78 | 9.55 | 18 | 312899 | 824 | 64184991 |
Injection site warmth | 12.77 | 9.55 | 29 | 312888 | 13433 | 64172382 |
Sputum purulent | 12.72 | 9.55 | 22 | 312895 | 1204 | 64184611 |
Polydipsia | 12.71 | 9.55 | 59 | 312858 | 5762 | 64180053 |
Alcoholism | 12.71 | 9.55 | 41 | 312876 | 3376 | 64182439 |
Change of bowel habit | 12.69 | 9.55 | 33 | 312884 | 2405 | 64183410 |
Nephropathy toxic | 12.69 | 9.55 | 43 | 312874 | 17471 | 64168344 |
Alcohol use | 12.64 | 9.55 | 50 | 312867 | 4552 | 64181263 |
Euthanasia | 12.64 | 9.55 | 6 | 312911 | 52 | 64185763 |
Colitis ulcerative | 12.63 | 9.55 | 63 | 312854 | 22965 | 64162850 |
Skin exfoliation | 12.61 | 9.55 | 148 | 312769 | 44737 | 64141078 |
Intraocular pressure increased | 12.58 | 9.55 | 13 | 312904 | 8289 | 64177526 |
Myocardial reperfusion injury | 12.52 | 9.55 | 5 | 312912 | 27 | 64185788 |
Apallic syndrome | 12.50 | 9.55 | 18 | 312899 | 841 | 64184974 |
Diabetic ketoacidosis | 12.49 | 9.55 | 89 | 312828 | 29756 | 64156059 |
Upper respiratory fungal infection | 12.48 | 9.55 | 11 | 312906 | 296 | 64185519 |
Heart rate increased | 12.48 | 9.55 | 592 | 312325 | 98083 | 64087732 |
Lip swelling | 12.46 | 9.55 | 97 | 312820 | 31810 | 64154005 |
Injection site haemorrhage | 12.43 | 9.55 | 68 | 312849 | 24210 | 64161605 |
Psychomotor skills impaired | 12.41 | 9.55 | 44 | 312873 | 3801 | 64182014 |
Induced abortion failed | 12.39 | 9.55 | 9 | 312908 | 182 | 64185633 |
Pseudophaeochromocytoma | 12.37 | 9.55 | 7 | 312910 | 90 | 64185725 |
Echopraxia | 12.37 | 9.55 | 5 | 312912 | 28 | 64185787 |
Nephrotic syndrome | 12.34 | 9.55 | 17 | 312900 | 9550 | 64176265 |
Electroconvulsive therapy | 12.30 | 9.55 | 7 | 312910 | 91 | 64185724 |
Perseveration | 12.27 | 9.55 | 12 | 312905 | 370 | 64185445 |
Hyporesponsive to stimuli | 12.24 | 9.55 | 27 | 312890 | 1770 | 64184045 |
Skin reaction | 12.22 | 9.55 | 26 | 312891 | 12326 | 64173489 |
Aphasia | 12.21 | 9.55 | 272 | 312645 | 40634 | 64145181 |
Bronchiectasis | 12.20 | 9.55 | 32 | 312885 | 14108 | 64171707 |
Drug clearance decreased | 12.17 | 9.55 | 34 | 312883 | 2585 | 64183230 |
Creatinine renal clearance decreased | 12.17 | 9.55 | 33 | 312884 | 14388 | 64171427 |
Myalgia | 12.16 | 9.55 | 637 | 312280 | 157980 | 64027835 |
Dystonic tremor | 12.14 | 9.55 | 9 | 312908 | 188 | 64185627 |
Nocardiosis | 12.11 | 9.55 | 4 | 312913 | 4763 | 64181052 |
Differential white blood cell count abnormal | 12.11 | 9.55 | 27 | 312890 | 1783 | 64184032 |
Exposure via breast milk | 12.09 | 9.55 | 17 | 312900 | 777 | 64185038 |
Pancytopenia | 12.06 | 9.55 | 570 | 312347 | 142739 | 64043076 |
Panic disorder | 12.04 | 9.55 | 35 | 312882 | 2722 | 64183093 |
Flight of ideas | 12 | 9.55 | 16 | 312901 | 695 | 64185120 |
Middle insomnia | 12.00 | 9.55 | 105 | 312812 | 12772 | 64173043 |
Pain in jaw | 11.99 | 9.55 | 133 | 312784 | 40622 | 64145193 |
Inappropriate affect | 11.94 | 9.55 | 22 | 312895 | 1266 | 64184549 |
Anxiety disorder | 11.82 | 9.55 | 43 | 312874 | 3762 | 64182053 |
Hypotonia | 11.82 | 9.55 | 94 | 312823 | 11118 | 64174697 |
Tangentiality | 11.76 | 9.55 | 8 | 312909 | 145 | 64185670 |
Partial seizures | 11.75 | 9.55 | 68 | 312849 | 7239 | 64178576 |
Semen volume decreased | 11.73 | 9.55 | 6 | 312911 | 62 | 64185753 |
Polydipsia psychogenic | 11.70 | 9.55 | 9 | 312908 | 199 | 64185616 |
Memory impairment | 11.69 | 9.55 | 518 | 312399 | 85164 | 64100651 |
Acute respiratory failure | 11.61 | 9.55 | 321 | 312596 | 49613 | 64136202 |
Neonatal hypoxia | 11.61 | 9.55 | 4 | 312913 | 13 | 64185802 |
Nerve degeneration | 11.60 | 9.55 | 10 | 312907 | 261 | 64185554 |
Sexual dysfunction | 11.59 | 9.55 | 62 | 312855 | 6409 | 64179406 |
Rash erythematous | 11.59 | 9.55 | 166 | 312751 | 48467 | 64137348 |
Negative thoughts | 11.58 | 9.55 | 22 | 312895 | 1296 | 64184519 |
Brain abscess | 11.55 | 9.55 | 3 | 312914 | 4178 | 64181637 |
Muscle twitching | 11.55 | 9.55 | 142 | 312775 | 18856 | 64166959 |
Hepatotoxicity | 11.53 | 9.55 | 131 | 312786 | 39831 | 64145984 |
Klebsiella bacteraemia | 11.49 | 9.55 | 31 | 312886 | 2309 | 64183506 |
Labelled drug-food interaction medication error | 11.49 | 9.55 | 6 | 312911 | 65 | 64185750 |
Toxicologic test abnormal | 11.45 | 9.55 | 21 | 312896 | 1204 | 64184611 |
Hypoprolactinaemia | 11.39 | 9.55 | 4 | 312913 | 14 | 64185801 |
Aortic valve stenosis | 11.36 | 9.55 | 4 | 312913 | 4576 | 64181239 |
Rabbit syndrome | 11.30 | 9.55 | 11 | 312906 | 337 | 64185478 |
Forced expiratory volume decreased | 11.28 | 9.55 | 10 | 312907 | 6857 | 64178958 |
Blood potassium decreased | 11.24 | 9.55 | 266 | 312651 | 40133 | 64145682 |
Multiple drug therapy | 11.21 | 9.55 | 30 | 312887 | 2224 | 64183591 |
Injection site rash | 11.16 | 9.55 | 39 | 312878 | 15703 | 64170112 |
Psychiatric symptom | 11.16 | 9.55 | 60 | 312857 | 6213 | 64179602 |
Graft versus host disease in skin | 11.16 | 9.55 | 6 | 312911 | 5341 | 64180474 |
Pallor | 10.99 | 9.55 | 256 | 312661 | 38525 | 64147290 |
Neck mass | 10.99 | 9.55 | 3 | 312914 | 4041 | 64181774 |
Natural killer cell count | 10.97 | 9.55 | 4 | 312913 | 16 | 64185799 |
Cerebral haemorrhage | 10.94 | 9.55 | 178 | 312739 | 50912 | 64134903 |
Hepatitis B reactivation | 10.94 | 9.55 | 5 | 312912 | 4884 | 64180931 |
Psychopathic personality | 10.94 | 9.55 | 3 | 312914 | 3 | 64185812 |
Thought withdrawal | 10.94 | 9.55 | 3 | 312914 | 3 | 64185812 |
Antidepressant drug level below therapeutic | 10.94 | 9.55 | 3 | 312914 | 3 | 64185812 |
Abortion spontaneous complete | 10.94 | 9.55 | 3 | 312914 | 3 | 64185812 |
Inflammatory marker increased | 10.92 | 9.55 | 15 | 312902 | 8436 | 64177379 |
Full blood count abnormal | 10.91 | 9.55 | 204 | 312713 | 29553 | 64156262 |
Sputum discoloured | 10.89 | 9.55 | 47 | 312870 | 17809 | 64168006 |
Selective mutism | 10.89 | 9.55 | 6 | 312911 | 73 | 64185742 |
Eczema | 10.85 | 9.55 | 92 | 312825 | 29628 | 64156187 |
Accidental exposure to product | 10.84 | 9.55 | 79 | 312838 | 26285 | 64159530 |
Libido decreased | 10.83 | 9.55 | 49 | 312868 | 4735 | 64181080 |
Ureteric obstruction | 10.82 | 9.55 | 31 | 312886 | 2391 | 64183424 |
Autoimmune haemolytic anaemia | 10.81 | 9.55 | 11 | 312906 | 7065 | 64178750 |
Epidural lipomatosis | 10.80 | 9.55 | 17 | 312900 | 860 | 64184955 |
Amegakaryocytic thrombocytopenia | 10.78 | 9.55 | 4 | 312913 | 17 | 64185798 |
Clonus | 10.78 | 9.55 | 58 | 312859 | 6009 | 64179806 |
Sensitivity to weather change | 10.77 | 9.55 | 10 | 312907 | 6704 | 64179111 |
Peritonitis bacterial | 10.76 | 9.55 | 17 | 312900 | 9026 | 64176789 |
Cardiac failure chronic | 10.75 | 9.55 | 17 | 312900 | 9024 | 64176791 |
Antidepressant drug level increased | 10.74 | 9.55 | 11 | 312906 | 359 | 64185456 |
Accident at work | 10.73 | 9.55 | 18 | 312899 | 961 | 64184854 |
Aplastic anaemia | 10.72 | 9.55 | 109 | 312808 | 13811 | 64172004 |
Eye disorder | 10.71 | 9.55 | 51 | 312866 | 18818 | 64166997 |
Premature delivery | 10.70 | 9.55 | 50 | 312867 | 18539 | 64167276 |
Post-injection delirium sedation syndrome | 10.68 | 9.55 | 13 | 312904 | 515 | 64185300 |
Bacterial test positive | 10.59 | 9.55 | 62 | 312855 | 6628 | 64179187 |
Hypertensive crisis | 10.55 | 9.55 | 49 | 312868 | 18199 | 64167616 |
Blood creatine increased | 10.53 | 9.55 | 72 | 312845 | 8120 | 64177695 |
Ultrasound abdomen abnormal | 10.53 | 9.55 | 7 | 312910 | 122 | 64185693 |
Granuloma | 10.52 | 9.55 | 10 | 312907 | 6631 | 64179184 |
Angina unstable | 10.52 | 9.55 | 39 | 312878 | 15428 | 64170387 |
Refusal of treatment by relative | 10.51 | 9.55 | 15 | 312902 | 695 | 64185120 |
Neutrophil count increased | 10.44 | 9.55 | 176 | 312741 | 24998 | 64160817 |
Affective ambivalence | 10.43 | 9.55 | 4 | 312913 | 19 | 64185796 |
Constipation | 10.41 | 9.55 | 1268 | 311649 | 228069 | 63957746 |
Daydreaming | 10.39 | 9.55 | 16 | 312901 | 794 | 64185021 |
Food craving | 10.39 | 9.55 | 22 | 312895 | 1402 | 64184413 |
Jaundice | 10.39 | 9.55 | 169 | 312748 | 48343 | 64137472 |
Stevens-Johnson syndrome | 10.39 | 9.55 | 111 | 312806 | 34138 | 64151677 |
Hepatitis | 10.37 | 9.55 | 157 | 312760 | 45425 | 64140390 |
Immunoglobulins decreased | 10.37 | 9.55 | 21 | 312896 | 1297 | 64184518 |
Injury | 10.36 | 9.55 | 350 | 312567 | 55642 | 64130173 |
Varicella zoster virus infection | 10.35 | 9.55 | 3 | 312914 | 3885 | 64181930 |
Haemoglobin urine | 10.33 | 9.55 | 7 | 312910 | 126 | 64185689 |
Haematochezia | 10.33 | 9.55 | 244 | 312673 | 66129 | 64119686 |
Pneumoconiosis | 10.31 | 9.55 | 9 | 312908 | 239 | 64185576 |
Asthma | 10.30 | 9.55 | 368 | 312549 | 94857 | 64090958 |
Red cell distribution width increased | 10.26 | 9.55 | 98 | 312819 | 12211 | 64173604 |
Metabolic alkalosis | 10.25 | 9.55 | 42 | 312875 | 3886 | 64181929 |
Schizoaffective disorder bipolar type | 10.24 | 9.55 | 7 | 312910 | 128 | 64185687 |
Atypical femur fracture | 10.21 | 9.55 | 5 | 312912 | 4693 | 64181122 |
Left ventricle outflow tract obstruction | 10.21 | 9.55 | 10 | 312907 | 309 | 64185506 |
Feeling guilty | 10.20 | 9.55 | 16 | 312901 | 807 | 64185008 |
Blood osmolarity increased | 10.20 | 9.55 | 13 | 312904 | 540 | 64185275 |
Squamous cell carcinoma of the oral cavity | 10.19 | 9.55 | 12 | 312905 | 459 | 64185356 |
Posture abnormal | 10.17 | 9.55 | 38 | 312879 | 3368 | 64182447 |
B-cell lymphoma | 10.16 | 9.55 | 7 | 312910 | 5450 | 64180365 |
Disability | 10.16 | 9.55 | 28 | 312889 | 12144 | 64173671 |
Purpura | 10.15 | 9.55 | 46 | 312871 | 17200 | 64168615 |
Product storage error | 10.13 | 9.55 | 32 | 312885 | 13286 | 64172529 |
Depressive delusion | 10.11 | 9.55 | 4 | 312913 | 21 | 64185794 |
On and off phenomenon | 10.08 | 9.55 | 31 | 312886 | 2488 | 64183327 |
Gallbladder cholesterolosis | 10.01 | 9.55 | 13 | 312904 | 550 | 64185265 |
Phonophobia | 10.00 | 9.55 | 12 | 312905 | 468 | 64185347 |
Drug monitoring procedure incorrectly performed | 9.98 | 9.55 | 11 | 312906 | 391 | 64185424 |
Rales | 9.97 | 9.55 | 39 | 312878 | 15190 | 64170625 |
Cutaneous vasculitis | 9.96 | 9.55 | 10 | 312907 | 6463 | 64179352 |
Pancreatitis acute | 9.96 | 9.55 | 147 | 312770 | 42708 | 64143107 |
Wound infection fungal | 9.92 | 9.55 | 8 | 312909 | 190 | 64185625 |
Liver injury | 9.91 | 9.55 | 95 | 312822 | 29837 | 64155978 |
Nodule | 9.90 | 9.55 | 49 | 312868 | 17898 | 64167917 |
Immature granulocyte count increased | 9.88 | 9.55 | 12 | 312905 | 474 | 64185341 |
Hypopnoea | 9.84 | 9.55 | 36 | 312881 | 3158 | 64182657 |
Foot fracture | 9.78 | 9.55 | 50 | 312867 | 18107 | 64167708 |
Drug level increased | 9.77 | 9.55 | 226 | 312691 | 33970 | 64151845 |
Septic shock | 9.76 | 9.55 | 415 | 312502 | 105022 | 64080793 |
Deja vu | 9.75 | 9.55 | 5 | 312912 | 52 | 64185763 |
Disseminated intravascular coagulation | 9.74 | 9.55 | 105 | 312812 | 32243 | 64153572 |
Assisted suicide | 9.73 | 9.55 | 3 | 312914 | 6 | 64185809 |
Gerstmann's syndrome | 9.73 | 9.55 | 3 | 312914 | 6 | 64185809 |
Hyponatraemic syndrome | 9.69 | 9.55 | 15 | 312902 | 748 | 64185067 |
Morbihan disease | 9.67 | 9.55 | 4 | 312913 | 24 | 64185791 |
Post procedural infection | 9.66 | 9.55 | 20 | 312897 | 9577 | 64176238 |
Disease recurrence | 9.60 | 9.55 | 102 | 312815 | 31408 | 64154407 |
Eczema eyelids | 9.57 | 9.55 | 7 | 312910 | 143 | 64185672 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Nasal congestion | 27.29 | 24.56 | 9 | 400 | 25 | 84244 |
Hypotonia neonatal | 25.92 | 24.56 | 23 | 386 | 644 | 83625 |
Source | Code | Description |
---|---|---|
ATC | N05BA06 | NERVOUS SYSTEM PSYCHOLEPTICS ANXIOLYTICS Benzodiazepine derivatives |
ATC | N05BA56 | NERVOUS SYSTEM PSYCHOLEPTICS ANXIOLYTICS Benzodiazepine derivatives |
FDA CS | M0002356 | Benzodiazepines |
MeSH PA | D014151 | Anti-Anxiety Agents |
MeSH PA | D000927 | Anticonvulsants |
MeSH PA | D000932 | Antiemetics |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D018682 | GABA Agents |
MeSH PA | D018757 | GABA Modulators |
MeSH PA | D005765 | Gastrointestinal Agents |
MeSH PA | D006993 | Hypnotics and Sedatives |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D014149 | Tranquilizing Agents |
FDA EPC | N0000175694 | Benzodiazepine |
CHEBI has role | CHEBI:35717 | hypnotics |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Myoclonic seizure | indication | 37356005 | |
Atonic seizure | indication | 42365007 | |
Anxiety | indication | 48694002 | |
Absence seizure | indication | 79631006 | |
Lennox-Gastaut syndrome | indication | 230418006 | |
Status epilepticus | indication | 230456007 | DOID:1824 |
Panic disorder | indication | 371631005 | DOID:594 |
Sedation as Adjunct to Anesthesia | indication | ||
Induce Anterograde Amnesia | indication | ||
Delirium | off-label use | 2776000 | |
Alcohol withdrawal delirium | off-label use | 8635005 | |
General anesthesia | off-label use | 50697003 | |
Seizure disorder | off-label use | 128613002 | |
Alcohol withdrawal syndrome | off-label use | 191480000 | |
Insomnia | off-label use | 193462001 | |
Spasticity | off-label use | 221360009 | |
Chemotherapy-induced nausea and vomiting | off-label use | 236084000 | |
Akathisia | off-label use | 285145004 | |
Local anesthesia | off-label use | 386761002 | |
Cocaine-Associated Acute Ischemic Heart Disease | off-label use | ||
Manic Bipolar Disorder Adjunct Treatment | off-label use | ||
Sedation in Intubated Patients | off-label use | ||
Suicidal thoughts | contraindication | 6471006 | |
Hepatic encephalopathy | contraindication | 13920009 | DOID:13413 |
Alcohol intoxication | contraindication | 25702006 | |
Depressive disorder | contraindication | 35489007 | |
Acute nephropathy | contraindication | 58574008 | |
Hepatic failure | contraindication | 59927004 | |
Substance abuse | contraindication | 66214007 | |
Sleep apnea | contraindication | 73430006 | DOID:0050847 |
Decreased respiratory function | contraindication | 80954004 | |
Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Hypoalbuminemia | contraindication | 119247004 | |
Liver function tests abnormal | contraindication | 166603001 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Syncope | contraindication | 271594007 | |
Pregnancy, function | contraindication | 289908002 | |
Severe chronic obstructive pulmonary disease | contraindication | 313299006 | |
At risk for aspiration | contraindication | 371736008 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Breastfeeding (mother) | contraindication | 413712001 | |
Chronic lung disease | contraindication | 413839001 | |
Central nervous system depression | contraindication | 418072004 | |
Porphyria | contraindication | 418470004 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.09 | acidic |
pKa2 | 11.41 | acidic |
pKa3 | 0.63 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
1.5MG | LOREEV XR | ALMATICA | N214826 | Feb. 16, 2022 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8999393 | Jan. 8, 2034 | ONCE DAILY TREATMENT OF ANXIETY DISORDER IN ADULTS |
1MG | LOREEV XR | ALMATICA | N214826 | Aug. 27, 2021 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8999393 | Jan. 8, 2034 | ONCE DAILY TREATMENT OF ANXIETY DISORDER IN ADULTS |
2MG | LOREEV XR | ALMATICA | N214826 | Aug. 27, 2021 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8999393 | Jan. 8, 2034 | ONCE DAILY TREATMENT OF ANXIETY DISORDER IN ADULTS |
3MG | LOREEV XR | ALMATICA | N214826 | Aug. 27, 2021 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8999393 | Jan. 8, 2034 | ONCE DAILY TREATMENT OF ANXIETY DISORDER IN ADULTS |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
GABA-A receptor alpha-1/beta-3/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | IC50 | 8.46 | WOMBAT-PK | CHEMBL | |||
Fatty acid-binding protein, liver | Unclassified | Ki | 4.89 | CHEMBL |
ID | Source |
---|---|
4017848 | VUID |
N0000146205 | NUI |
D00365 | KEGG_DRUG |
4017848 | VANDF |
C0024002 | UMLSCUI |
CHEBI:6539 | CHEBI |
CHEMBL249262 | ChEMBL_ID |
CHEMBL580 | ChEMBL_ID |
CHEMBL399057 | ChEMBL_ID |
DB00186 | DRUGBANK_ID |
D008140 | MESH_DESCRIPTOR_UI |
3958 | PUBCHEM_CID |
5884 | IUPHAR_LIGAND_ID |
2809 | INN_ID |
O26FZP769L | UNII |
202479 | RXNORM |
2104 | MMSL |
3795 | MMSL |
4995 | MMSL |
d00149 | MMSL |
001460 | NDDF |
19225000 | SNOMEDCT_US |
387106007 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-3532 | SOLUTION, CONCENTRATE | 2 mg | ORAL | ANDA | 19 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3425 | TABLET | 0.50 mg | ORAL | ANDA | 21 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3425 | TABLET | 0.50 mg | ORAL | ANDA | 21 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3426 | TABLET | 1 mg | ORAL | ANDA | 21 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3426 | TABLET | 1 mg | ORAL | ANDA | 21 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3427 | TABLET | 2 mg | ORAL | ANDA | 21 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3427 | TABLET | 2 mg | ORAL | ANDA | 21 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0770 | LIQUID | 2 mg | ORAL | ANDA | 21 sections |
Ativan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-0063 | TABLET | 0.50 mg | ORAL | NDA | 20 sections |
Ativan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-0064 | TABLET | 1 mg | ORAL | NDA | 20 sections |
Ativan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-0065 | TABLET | 2 mg | ORAL | NDA | 20 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1539 | INJECTION, SOLUTION | 4 mg | INTRAMUSCULAR | ANDA | 33 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1539 | INJECTION, SOLUTION | 4 mg | INTRAMUSCULAR | ANDA | 33 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1985 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | ANDA | 33 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1985 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | ANDA | 33 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-6778 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | ANDA | 33 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-6778 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | ANDA | 33 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-6778 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | ANDA | 33 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-6778 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | ANDA | 33 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-6779 | INJECTION, SOLUTION | 4 mg | INTRAMUSCULAR | ANDA | 33 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-6779 | INJECTION, SOLUTION | 4 mg | INTRAMUSCULAR | ANDA | 33 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-6780 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | ANDA | 33 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-6780 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | ANDA | 33 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-6781 | INJECTION, SOLUTION | 4 mg | INTRAMUSCULAR | ANDA | 33 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-6781 | INJECTION, SOLUTION | 4 mg | INTRAMUSCULAR | ANDA | 33 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-0240 | TABLET | 0.50 mg | ORAL | ANDA | 20 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-0241 | TABLET | 1 mg | ORAL | ANDA | 20 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-0242 | TABLET | 2 mg | ORAL | ANDA | 20 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8075 | TABLET | 0.50 mg | ORAL | ANDA | 13 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8076 | TABLET | 1 mg | ORAL | ANDA | 13 sections |