lorazepam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diazepam derivatives 1606 846-49-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ativan
  • Wy 4036
  • Wy-4036
  • lorazepam
A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.
  • Molecular weight: 321.16
  • Formula: C15H10Cl2N2O2
  • CLOGP: 2.37
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 61.69
  • ALOGS: -4.26
  • ROTB: 1
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2.50 mg O
2.50 mg P
2.50 mg SL

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.08 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.44 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 93 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.09 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 17 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Sept. 30, 1977 FDA VALEANT INTL

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sopor 2093.81 9.54 1291 290015 20873 63176843
Drug abuse 1256.05 9.54 1605 289701 70913 63126803
Completed suicide 595.15 9.54 1740 289566 143933 63053783
Suicide attempt 565.37 9.54 1008 290298 59910 63137806
Intentional overdose 450.86 9.54 1029 290277 73123 63124593
Somnolence 430.75 9.54 1792 289514 176893 63020823
Neuroleptic malignant syndrome 425.26 9.54 389 290917 11667 63186049
Intentional self-injury 421.60 9.54 554 290752 25133 63172583
Bradyphrenia 387.73 9.54 293 291013 6687 63191029
Agitation 380.83 9.54 845 290461 58912 63138804
Overdose 378.88 9.54 1276 290030 113802 63083914
Coma 344.45 9.54 850 290456 63514 63134202
Drug ineffective 332.57 9.54 3134 288172 1041631 62156085
Contraindicated product administered 302.89 9.54 331 290975 217317 62980399
Delirium 299.01 9.54 694 290612 49847 63147869
Toxicity to various agents 280.66 9.54 2019 289287 245231 62952485
Systemic lupus erythematosus 262.69 9.54 344 290962 208574 62989142
Drug intolerance 252.53 9.54 661 290645 308000 62889716
Pemphigus 250.54 9.54 284 291022 183442 63014274
Catatonia 242.20 9.54 185 291121 4292 63193424
Arthropathy 238.66 9.54 446 290860 234346 62963370
Joint swelling 227.98 9.54 757 290549 326909 62870807
Alopecia 222.55 9.54 798 290508 336738 62860978
Drug withdrawal syndrome 220.80 9.54 425 290881 26769 63170947
Serotonin syndrome 213.25 9.54 432 290874 28250 63169466
Treatment failure 195.33 9.54 386 290920 198657 62999059
Suicidal ideation 194.66 9.54 680 290626 61741 63135975
Pain 193.57 9.54 2323 288983 738305 62459411
Drug interaction 192.38 9.54 1747 289559 227384 62970332
Anxiety 191.03 9.54 1675 289631 215866 62981850
Glossodynia 181.51 9.54 340 290966 178536 63019180
Therapeutic product effect decreased 179.94 9.54 386 290920 192801 63004915
Hand deformity 178.28 9.54 285 291021 159172 63038544
Disorientation 176.15 9.54 487 290819 38965 63158751
Poisoning 174.92 9.54 262 291044 13438 63184278
Hypersensitivity 170.43 9.54 727 290579 291958 62905758
Tachycardia 167.85 9.54 1021 290285 117135 63080581
Arthralgia 164.29 9.54 1747 289559 567963 62629753
Restlessness 163.93 9.54 395 290911 29058 63168658
Swelling 163.42 9.54 679 290627 274699 62923017
Mydriasis 163.26 9.54 236 291070 11720 63185996
Rheumatoid arthritis 161.96 9.54 608 290698 253211 62944505
Psychotic disorder 161.94 9.54 362 290944 25350 63172366
Confusional state 159.82 9.54 1723 289583 234657 62963059
Rash 156.05 9.54 1734 289572 559137 62638579
Depressed level of consciousness 154.35 9.54 629 290677 61449 63136267
Bradykinesia 153.64 9.54 152 291154 5036 63192680
Pneumonia aspiration 151.86 9.54 424 290882 34116 63163600
Respiratory depression 151.00 9.54 245 291061 13470 63184246
Drug dependence 150.07 9.54 341 290965 24142 63173574
Abdominal discomfort 147.89 9.54 865 290441 320020 62877696
Synovitis 144.65 9.54 411 290895 186507 63011209
Mania 144.51 9.54 227 291079 12140 63185576
Akathisia 131.45 9.54 185 291121 8961 63188755
Extrapyramidal disorder 123.38 9.54 220 291086 13064 63184652
Maternal exposure during pregnancy 119.36 9.54 561 290745 219501 62978215
Speech disorder 119.28 9.54 434 290872 40195 63157521
Infusion related reaction 111.89 9.54 664 290642 244857 62952859
Anti-cyclic citrullinated peptide antibody positive 110.82 9.54 229 291077 115983 63081733
Febrile neutropenia 110.12 9.54 924 290382 117525 63080191
Muscle rigidity 110.09 9.54 193 291113 11307 63186409
Tremor 108.16 9.54 1003 290303 131236 63066480
Delusion 103.97 9.54 193 291113 11824 63185892
Mental status changes 102.22 9.54 406 290900 39193 63158523
Psychomotor hyperactivity 99.55 9.54 177 291129 10486 63187230
Wound 98.35 9.54 400 290906 162863 63034853
Abnormal behaviour 97.13 9.54 266 291040 21160 63176556
Hallucination, auditory 95.13 9.54 193 291113 12631 63185085
Slow speech 93.48 9.54 68 291238 1461 63196255
Hypothermia 92.10 9.54 197 291109 13384 63184332
Respiratory arrest 91.87 9.54 344 290962 32301 63165415
Aggression 91.30 9.54 276 291030 23222 63174494
Tardive dyskinesia 91.06 9.54 150 291156 8352 63189364
Psychomotor retardation 90.61 9.54 100 291206 3770 63193946
Product use issue 89.89 9.54 617 290689 219903 62977813
Hepatic enzyme increased 89.63 9.54 552 290754 201776 62995940
Seizure 89.14 9.54 966 290340 131668 63066048
Device expulsion 88.82 9.54 25 291281 34897 63162819
COVID-19 88.70 9.54 247 291059 112856 63084860
Off label use 88.24 9.54 2389 288917 672073 62525643
Dysarthria 87.97 9.54 409 290897 42302 63155414
Withdrawal syndrome 84.49 9.54 242 291064 19755 63177961
Gastric pH decreased 83.16 9.54 49 291257 725 63196991
Derealisation 81.39 9.54 57 291249 1151 63196565
Schizophrenia 81.34 9.54 156 291150 9796 63187920
Mutism 80.88 9.54 64 291242 1566 63196150
Mobility decreased 80.62 9.54 285 291021 120874 63076842
Electrocardiogram QT prolonged 80.45 9.54 508 290798 59022 63138694
Drug hypersensitivity 79.00 9.54 979 290327 309708 62888008
Depression 77.99 9.54 1301 290005 195191 63002525
Status epilepticus 76.03 9.54 196 291110 15037 63182679
Bezoar 75.90 9.54 60 291246 1466 63196250
Unresponsive to stimuli 75.76 9.54 332 290974 33484 63164232
Pericarditis 75.74 9.54 328 290978 131251 63066465
Drooling 75.51 9.54 91 291215 3777 63193939
Therapeutic product effect incomplete 74.29 9.54 308 290998 124748 63072968
Cogwheel rigidity 74.26 9.54 66 291240 1904 63195812
Cardiac arrest 74.17 9.54 699 290607 91846 63105870
Sedation 72.96 9.54 362 290944 38447 63159269
Discomfort 72.88 9.54 459 290847 166915 63030801
Substance abuse 71.72 9.54 99 291207 4708 63193008
Sinus tachycardia 71.02 9.54 259 291047 24009 63173707
Pneumonia viral 69.50 9.54 128 291178 7794 63189922
Hallucination 69.30 9.54 460 290846 54357 63143359
Soft tissue disorder 68.89 9.54 93 291213 4329 63193387
Hyponatraemia 68.82 9.54 801 290505 111099 63086617
Injection site pain 68.51 9.54 334 290972 129466 63068250
Dehydration 68.12 9.54 1146 290160 172208 63025508
Incontinence 67.96 9.54 159 291147 11473 63186243
Salivary hypersecretion 67.43 9.54 124 291182 7542 63190174
Rheumatoid factor positive 65.67 9.54 185 291121 84221 63113495
Injection site erythema 64.94 9.54 182 291124 82992 63114724
Dissociation 64.19 9.54 73 291233 2846 63194870
Paranoia 63.23 9.54 155 291151 11524 63186192
Electrocardiogram QRS complex prolonged 62.57 9.54 104 291202 5834 63191882
Psoriasis 62.32 9.54 198 291108 86759 63110957
Dystonia 62.08 9.54 171 291135 13648 63184068
Mental disorder 60.77 9.54 258 291048 25661 63172055
Sinusitis 60.70 9.54 706 290600 225947 62971769
Infection 59.39 9.54 719 290587 228454 62969262
Feeling of despair 59.24 9.54 63 291243 2276 63195440
Brain injury 58.30 9.54 111 291195 6932 63190784
Hypoxia 56.36 9.54 468 290838 59324 63138392
Hypokinesia 56.33 9.54 166 291140 13770 63183946
Pruritus 56.17 9.54 1247 290059 360206 62837510
Loss of consciousness 55.97 9.54 806 290500 117315 63080401
Depersonalisation/derealisation disorder 55.81 9.54 48 291258 1324 63196392
Persecutory delusion 55.05 9.54 66 291240 2724 63194992
Computerised tomogram thorax abnormal 54.72 9.54 53 291253 1710 63196006
Narcotic bowel syndrome 54.49 9.54 22 291284 131 63197585
Stupor 53.49 9.54 81 291225 4194 63193522
Peripheral swelling 53.44 9.54 878 290428 265064 62932652
Product dose omission issue 53.42 9.54 755 290551 233558 62964158
Interstitial lung disease 53.27 9.54 129 291177 61779 63135937
Myelosuppression 53.23 9.54 21 291285 23682 63174034
Hallucinations, mixed 52.80 9.54 86 291220 4743 63192973
Hallucination, visual 52.35 9.54 201 291105 19097 63178619
Blister 51.00 9.54 367 290939 129447 63068269
Cardio-respiratory arrest 50.61 9.54 458 290848 59501 63138215
Computerised tomogram thorax 49.75 9.54 29 291277 420 63197296
H1N1 influenza 49.74 9.54 50 291256 1689 63196027
Alcohol interaction 49.21 9.54 58 291248 2351 63195365
Nasopharyngitis 48.93 9.54 846 290460 253411 62944305
Dyskinesia 48.90 9.54 282 291024 31720 63165996
Coma scale abnormal 48.70 9.54 86 291220 5067 63192649
Multiple-drug resistance 48.49 9.54 86 291220 5084 63192632
Therapeutic response decreased 48.49 9.54 134 291172 61391 63136325
Respiratory failure 48.24 9.54 695 290611 101163 63096553
Diabetes insipidus 46.80 9.54 59 291247 2566 63195150
Erythema 45.67 9.54 551 290755 175200 63022516
Injection site reaction 44.26 9.54 130 291176 58394 63139322
Skin necrosis 43.81 9.54 6 291300 13944 63183772
Fall 43.76 9.54 2210 289096 390124 62807592
C-reactive protein increased 43.68 9.54 255 291051 94452 63103264
Condition aggravated 43.66 9.54 1460 289846 400757 62796959
Headache 42.89 9.54 2423 288883 630818 62566898
Lower respiratory tract infection 42.82 9.54 394 290912 131913 63065803
Miosis 42.40 9.54 100 291206 7253 63190463
Injection site pruritus 41.24 9.54 91 291215 45025 63152691
Panic attack 41.05 9.54 207 291099 22124 63175592
Red blood cell sedimentation rate increased 40.79 9.54 88 291218 43894 63153822
Hypertonia 40.77 9.54 75 291231 4562 63193154
Mood swings 40.75 9.54 179 291127 18069 63179647
Psoriatic arthropathy 40.32 9.54 250 291056 91270 63106446
Cytomegalovirus infection 40.25 9.54 23 291283 20929 63176787
Compartment syndrome 40.18 9.54 51 291255 2233 63195483
Alcohol abuse 39.48 9.54 49 291257 2097 63195619
Hypotension 39.44 9.54 1577 289729 271027 62926689
Osmolar gap increased 39.39 9.54 16 291290 97 63197619
Encephalitis autoimmune 39.37 9.54 41 291265 1445 63196271
Disorganised speech 39.21 9.54 38 291268 1227 63196489
Hyperreflexia 39.00 9.54 85 291221 5849 63191867
Pain in extremity 38.89 9.54 1191 290115 330295 62867421
Crying 38.52 9.54 210 291096 23133 63174583
Somatic symptom disorder 38.51 9.54 54 291252 2606 63195110
Apnoea 37.77 9.54 101 291205 7921 63189795
Insomnia 37.38 9.54 1271 290035 213981 62983735
Decorticate posture 37.15 9.54 21 291285 286 63197430
Myocardial depression 36.83 9.54 25 291281 479 63197237
Emotional disorder 36.82 9.54 140 291166 13239 63184477
Newborn persistent pulmonary hypertension 36.59 9.54 19 291287 216 63197500
Tachypnoea 36.59 9.54 167 291139 17135 63180581
Small intestinal obstruction 36.58 9.54 174 291132 18163 63179553
Myoclonus 36.46 9.54 157 291149 15711 63182005
Mental impairment 36.44 9.54 145 291161 14006 63183710
Urinary retention 35.74 9.54 250 291056 30051 63167665
Poisoning deliberate 35.63 9.54 123 291183 11095 63186621
Deep vein thrombosis postoperative 35.54 9.54 124 291182 11245 63186471
Change of bowel habit 35.51 9.54 47 291259 2146 63195570
Nicotine dependence 35.25 9.54 28 291278 689 63197027
Drug eruption 35.24 9.54 48 291258 28646 63169070
Propofol infusion syndrome 35.21 9.54 32 291274 951 63196765
Respiratory acidosis 35.17 9.54 88 291218 6627 63191089
Injection site swelling 35.01 9.54 107 291199 47465 63150251
Abortion spontaneous 34.84 9.54 106 291200 47089 63150627
Oral pain 34.52 9.54 236 291070 28158 63169558
Loss of personal independence in daily activities 34.46 9.54 283 291023 97007 63100709
Victim of sexual abuse 34.25 9.54 27 291279 657 63197059
Psychiatric decompensation 34.19 9.54 37 291269 1364 63196352
Blood prolactin increased 33.80 9.54 59 291247 3444 63194272
Red blood cell sedimentation rate abnormal 33.54 9.54 25 291281 19757 63177959
Atelectasis 33.27 9.54 190 291116 21293 63176423
Knee arthroplasty 33.12 9.54 132 291174 54074 63143642
Dysphagia 33.09 9.54 581 290725 88004 63109712
Patient uncooperative 32.61 9.54 17 291289 195 63197521
Mouth ulceration 32.27 9.54 64 291242 32920 63164796
PO2 increased 32.24 9.54 29 291277 850 63196866
Basal cell carcinoma 32.23 9.54 49 291257 27942 63169774
Parosmia 32.16 9.54 81 291225 6125 63191591
Anaphylactic shock 31.66 9.54 37 291269 23596 63174120
Encephalopathy 31.07 9.54 292 291014 38328 63159388
Lip dry 31.01 9.54 147 291159 15323 63182393
Blood pH decreased 30.94 9.54 48 291258 2539 63195177
Pulseless electrical activity 30.79 9.54 90 291216 7431 63190285
Asthenia 30.39 9.54 2096 289210 381508 62816208
Disturbance in attention 30.35 9.54 288 291018 37901 63159815
Exposure during pregnancy 30.07 9.54 517 290789 155030 63042686
Nightmare 29.89 9.54 170 291136 19024 63178692
Feeling of body temperature change 29.77 9.54 68 291238 4829 63192887
CSF oligoclonal band present 29.61 9.54 20 291286 380 63197336
Renal ischaemia 29.59 9.54 24 291282 609 63197107
Aspiration 29.41 9.54 113 291193 10738 63186978
Cataract 29.40 9.54 148 291158 56905 63140811
Facet joint syndrome 29.37 9.54 122 291184 12016 63185700
Electroencephalogram abnormal 29.32 9.54 57 291249 3615 63194101
Wrong patient received product 29.31 9.54 43 291263 2164 63195552
Myocardial reperfusion injury 29.29 9.54 13 291293 101 63197615
Joint injury 29.26 9.54 57 291249 29515 63168201
Blood creatine phosphokinase increased 29.11 9.54 239 291067 30191 63167525
Musculoskeletal stiffness 28.88 9.54 636 290670 183982 63013734
Lethargy 28.87 9.54 388 290918 55619 63142097
Breast cancer female 28.86 9.54 13 291293 13546 63184170
Hypotonia neonatal 28.83 9.54 32 291274 1214 63196502
Generalised tonic-clonic seizure 28.35 9.54 229 291077 28787 63168929
Intentional product misuse 28.17 9.54 414 290892 60503 63137213
Skin ulcer 28.12 9.54 102 291204 42943 63154773
Feeling jittery 28.07 9.54 129 291177 13274 63184442
Bradycardia 27.96 9.54 482 290824 72745 63124971
Constipation 27.96 9.54 1281 290025 223662 62974054
Pancreatic fibrosis 27.86 9.54 12 291294 86 63197630
Aphasia 27.80 9.54 252 291054 32748 63164968
Hepatic function abnormal 27.72 9.54 83 291223 37059 63160657
Parkinsonism 27.72 9.54 108 291198 10331 63187385
Restless legs syndrome 27.47 9.54 162 291144 18369 63179347
Panniculitis 27.41 9.54 9 291297 11376 63186340
PCO2 increased 27.27 9.54 31 291275 1208 63196508
Hypophagia 27.00 9.54 240 291066 31019 63166697
Neonatal seizure 26.99 9.54 21 291285 501 63197215
Respiratory distress 26.96 9.54 256 291050 33695 63164021
Macular degeneration 26.80 9.54 44 291262 24332 63173384
Peripheral venous disease 26.73 9.54 141 291165 15336 63182380
Tenosynovitis 26.70 9.54 15 291291 13780 63183936
Bronchiectasis 26.60 9.54 21 291285 16121 63181595
Accidental exposure to product by child 26.51 9.54 30 291276 1163 63196553
Obsessive-compulsive disorder 26.51 9.54 58 291248 4002 63193714
Major depression 26.42 9.54 89 291217 7929 63189787
Cerebral microhaemorrhage 26.39 9.54 13 291293 131 63197585
Mean cell haemoglobin increased 26.38 9.54 48 291258 2895 63194821
Schizophreniform disorder 26.38 9.54 11 291295 72 63197644
Neonatal asphyxia 26.25 9.54 17 291289 300 63197416
Brain death 26.10 9.54 52 291254 3358 63194358
Phagophobia 26.04 9.54 10 291296 51 63197665
Morbid thoughts 25.76 9.54 22 291284 601 63197115
Premature delivery 25.34 9.54 64 291242 30217 63167499
Granulocytopenia 25.29 9.54 70 291236 5602 63192114
Plasma cell myeloma 25.25 9.54 264 291042 35641 63162075
Mitochondrial encephalomyopathy 24.90 9.54 8 291298 21 63197695
Hyperammonaemic encephalopathy 24.80 9.54 42 291264 2392 63195324
Immunodeficiency 24.75 9.54 34 291272 20220 63177496
Emotional distress 24.65 9.54 243 291063 32306 63165410
Antipsychotic drug level increased 24.65 9.54 51 291255 3384 63194332
Bone erosion 24.54 9.54 27 291279 17690 63180026
Pneumocystis jirovecii pneumonia 24.29 9.54 25 291281 16889 63180827
Coma scale 24.26 9.54 9 291297 41 63197675
Macrocytosis 24.17 9.54 42 291264 2443 63195273
Femur fracture 24.06 9.54 104 291202 41652 63156064
Depressed mood 23.93 9.54 286 291020 39905 63157811
Blood bicarbonate decreased 23.91 9.54 46 291260 2895 63194821
Hyperhidrosis 23.85 9.54 656 290650 107180 63090536
Dry mouth 23.71 9.54 495 290811 77368 63120348
Ill-defined disorder 23.70 9.54 250 291056 81505 63116211
Acute psychosis 23.68 9.54 42 291264 2483 63195233
Solar urticaria 23.54 9.54 10 291296 69 63197647
Homicide 23.26 9.54 17 291289 368 63197348
Neurosensory hypoacusis 23.25 9.54 14 291292 216 63197500
Areflexia 23.21 9.54 47 291259 3071 63194645
Menstrual disorder 23.13 9.54 65 291241 5248 63192468
Homicidal ideation 23.07 9.54 34 291272 1718 63195998
Neutropenic sepsis 22.82 9.54 25 291281 16413 63181303
Urinary incontinence 22.80 9.54 236 291070 31778 63165938
Malaise 22.65 9.54 1623 289683 414331 62783385
Upper respiratory tract infection 22.54 9.54 254 291052 81793 63115923
Bradypnoea 22.37 9.54 50 291256 3500 63194216
Suicidal behaviour 22.35 9.54 42 291264 2597 63195119
Hip arthroplasty 22.11 9.54 128 291178 47518 63150198
Sputum purulent 21.92 9.54 26 291280 1061 63196655
Blood sodium decreased 21.88 9.54 188 291118 24064 63173652
Mitochondrial DNA mutation 21.87 9.54 17 291289 405 63197311
Affective disorder 21.85 9.54 70 291236 6076 63191640
Muscle disorder 21.84 9.54 61 291245 4908 63192808
Sacroiliitis 21.80 9.54 47 291259 3210 63194506
Screaming 21.75 9.54 47 291259 3215 63194501
Impaired healing 21.74 9.54 335 290971 102207 63095509
Bone density decreased 21.67 9.54 21 291285 14591 63183125
Respiratory alkalosis 21.66 9.54 42 291264 2659 63195057
Toxic epidermal necrolysis 21.62 9.54 53 291253 25281 63172435
Communication disorder 21.44 9.54 40 291266 2460 63195256
Respiratory rate decreased 21.40 9.54 49 291257 3486 63194230
Impaired quality of life 21.40 9.54 19 291287 13764 63183952
Alcohol use 21.35 9.54 36 291270 2043 63195673
Ataxia 21.35 9.54 131 291175 15064 63182652
Skin reaction 21.27 9.54 22 291284 14827 63182889
Behaviour disorder 21.23 9.54 46 291260 3153 63194563
Apallic syndrome 21.12 9.54 21 291285 700 63197016
Autoimmune disorder 21.02 9.54 143 291163 17034 63180682
Foot deformity 20.96 9.54 62 291244 27791 63169925
Skin maceration 20.96 9.54 8 291298 40 63197676
Vomiting 20.95 9.54 2901 288405 556716 62641000
Hypochloraemia 20.92 9.54 35 291271 1974 63195742
Altered state of consciousness 20.92 9.54 192 291114 25038 63172678
Rectal polyp 20.75 9.54 27 291279 1212 63196504
Waxy flexibility 20.74 9.54 11 291295 131 63197585
Echolalia 20.70 9.54 13 291293 217 63197499
Osteoporosis 20.66 9.54 166 291140 57172 63140544
Coeliac disease 20.65 9.54 17 291289 12780 63184936
Device difficult to use 20.64 9.54 17 291289 12779 63184937
Staring 20.56 9.54 31 291275 1599 63196117
Paralysis 20.52 9.54 95 291211 9805 63187911
Therapy interrupted 20.48 9.54 78 291228 32377 63165339
Ulcer 20.46 9.54 57 291249 26050 63171666
Failure to thrive 20.37 9.54 76 291230 7122 63190594
Fear 20.34 9.54 133 291173 15633 63182083
Drop attacks 20.23 9.54 20 291286 662 63197054
Hypoxic-ischaemic encephalopathy 20.21 9.54 54 291252 4233 63193483
Bipolar disorder 20.04 9.54 81 291225 7879 63189837
Mood altered 20.02 9.54 126 291180 14617 63183099
Accidental death 20.01 9.54 34 291272 1942 63195774
Haematotoxicity 19.94 9.54 9 291297 9367 63188349
Haemophagocytic lymphohistiocytosis 19.94 9.54 12 291294 10615 63187101
Myocardial fibrosis 19.92 9.54 21 291285 751 63196965
Injection site bruising 19.77 9.54 112 291194 41798 63155918
Hepatic cytolysis 19.71 9.54 25 291281 15382 63182334
Protein C increased 19.62 9.54 10 291296 109 63197607
Rapid eye movements sleep abnormal 19.51 9.54 11 291295 149 63197567
Fibromyalgia 19.44 9.54 495 290811 79925 63117791
Ventricular hypokinesia 19.42 9.54 56 291250 4588 63193128
Alcohol poisoning 19.41 9.54 33 291273 1886 63195830
Leukocytosis 19.34 9.54 193 291113 25742 63171974
Device issue 19.33 9.54 51 291255 23730 63173986
Torsade de pointes 19.33 9.54 116 291190 13235 63184481
Oxygen saturation abnormal 19.28 9.54 47 291259 3482 63194234
Hyperprolactinaemia 19.27 9.54 50 291256 3850 63193866
Disease recurrence 19.26 9.54 65 291241 27965 63169751
Psychomotor skills impaired 19.21 9.54 37 291269 2331 63195385
Monocyte count decreased 19.15 9.54 35 291271 2118 63195598
Withdrawal catatonia 19.15 9.54 9 291297 81 63197635
Accidental overdose 19.13 9.54 177 291129 23132 63174584
Vitamin B1 decreased 19.12 9.54 12 291294 200 63197516
Refusal of treatment by patient 18.99 9.54 62 291244 5435 63192281
Renal impairment 18.95 9.54 288 291018 88067 63109649
Urine abnormality 18.95 9.54 73 291233 6946 63190770
Pallor 18.85 9.54 219 291087 30349 63167367
Drug use disorder 18.85 9.54 58 291248 4926 63192790
Drug tolerance decreased 18.79 9.54 32 291274 17441 63180275
Sleep disorder due to a general medical condition 18.68 9.54 17 291289 12171 63185545
Decreased appetite 18.68 9.54 1365 289941 249687 62948029
Oropharyngeal swelling 18.52 9.54 22 291284 899 63196817
Rhesus antigen positive 18.51 9.54 10 291296 124 63197592
Patent ductus arteriosus 18.51 9.54 52 291254 4198 63193518
Inappropriate antidiuretic hormone secretion 18.49 9.54 128 291178 15334 63182382
Pleocytosis 18.36 9.54 21 291285 824 63196892
Creatinine renal clearance decreased 18.34 9.54 29 291277 16279 63181437
Persistent left superior vena cava 18.34 9.54 7 291299 35 63197681
Frustration tolerance decreased 18.31 9.54 72 291234 6916 63190800
Polyarthritis 18.29 9.54 12 291294 10134 63187582
No adverse event 18.28 9.54 113 291193 41292 63156424
Arthritis 18.22 9.54 399 290907 115522 63082194
Ear infection 18.09 9.54 102 291204 38111 63159605
Alcoholism 18.04 9.54 31 291275 1787 63195929
Device malfunction 18.03 9.54 34 291272 17823 63179893
Rhabdomyolysis 17.76 9.54 292 291014 43659 63154057
Inflammation 17.71 9.54 268 291038 82005 63115711
Logorrhoea 17.70 9.54 37 291269 2473 63195243
Joint effusion 17.66 9.54 32 291274 17028 63180688
Dementia 17.65 9.54 147 291159 18647 63179069
Blood gases abnormal 17.64 9.54 20 291286 777 63196939
Tremor neonatal 17.58 9.54 10 291296 138 63197578
Neutrophil count increased 17.56 9.54 133 291173 16394 63181322
Generalised anxiety disorder 17.55 9.54 33 291273 2041 63195675
Therapy cessation 17.46 9.54 76 291230 30381 63167335
Haemoglobin urine 17.45 9.54 10 291296 140 63197576
Galactorrhoea 17.28 9.54 50 291256 4105 63193611
Rash pruritic 17.27 9.54 183 291123 59616 63138100
Laryngeal injury 17.20 9.54 5 291301 8 63197708
Finger deformity 17.17 9.54 7 291299 7738 63189978
Injection site rash 17.14 9.54 38 291268 18771 63178945
Medication error 17.11 9.54 336 290970 51948 63145768
Wrong drug 17.09 9.54 11 291295 192 63197524
Hypotonia 17.02 9.54 86 291220 9199 63188517
Metabolic encephalopathy 17.00 9.54 62 291244 5747 63191969
Metabolic alkalosis 16.97 9.54 41 291265 3020 63194696
Blood lactic acid decreased 16.97 9.54 10 291296 148 63197568
Device use error 16.91 9.54 3 291303 5758 63191958
Proctalgia 16.87 9.54 64 291242 6046 63191670
Joint destruction 16.81 9.54 4 291302 6248 63191468
Hyperchloraemia 16.64 9.54 19 291287 744 63196972
On and off phenomenon 16.54 9.54 30 291276 1805 63195911
Hypokalaemia 16.52 9.54 607 290699 103197 63094519
Cough 16.44 9.54 1139 290167 291604 62906112
Gallbladder disorder 16.44 9.54 145 291161 18697 63179019
Tracheal atresia 16.41 9.54 6 291300 26 63197690
Acute generalised exanthematous pustulosis 16.40 9.54 16 291290 11083 63186633
Unintentional medical device removal 16.27 9.54 4 291302 6111 63191605
pH urine increased 16.22 9.54 14 291292 388 63197328
Prescribed overdose 16.14 9.54 233 291073 33920 63163796
Anxiety disorder 16.14 9.54 48 291258 4002 63193714
Nervousness 16.12 9.54 215 291091 30764 63166952
Dysphemia 16.10 9.54 37 291269 2638 63195078
Irritability 16.10 9.54 219 291087 31475 63166241
Pleurothotonus 16.09 9.54 25 291281 1324 63196392
Muscle spasticity 16.05 9.54 49 291257 21745 63175971
Therapeutic product ineffective 16.01 9.54 29 291277 1743 63195973
Tendonitis 15.99 9.54 42 291264 19573 63178143
Neonatal behavioural syndrome 15.93 9.54 7 291299 53 63197663
Sleep disorder due to general medical condition, insomnia type 15.82 9.54 158 291148 52059 63145657
Atonic seizures 15.81 9.54 17 291289 622 63197094
Postural tremor 15.76 9.54 13 291293 338 63197378
Dopamine transporter scintigraphy abnormal 15.71 9.54 8 291298 87 63197629
Cardiac malposition 15.71 9.54 7 291299 55 63197661
Breast cancer stage I 15.64 9.54 6 291300 6883 63190833
Neonatal respiratory failure 15.61 9.54 12 291294 281 63197435
Bronchitis 15.58 9.54 445 290861 124490 63073226
Hypervigilance 15.54 9.54 13 291293 345 63197371
Cannabinoid hyperemesis syndrome 15.49 9.54 7 291299 57 63197659
Angioedema 15.44 9.54 143 291163 47822 63149894
Anger 15.42 9.54 104 291202 12352 63185364
Anomalous pulmonary venous connection 15.39 9.54 7 291299 58 63197658
Platelet production decreased 15.33 9.54 4 291302 3 63197713
Thymus disorder 15.33 9.54 12 291294 289 63197427
Self-medication 15.31 9.54 37 291269 2726 63194990
Cholangitis infective 15.29 9.54 13 291293 353 63197363
Gastrointestinal sounds abnormal 15.19 9.54 47 291259 4004 63193712
Apathy 15.11 9.54 80 291226 8714 63189002
Suspected suicide attempt 15.05 9.54 9 291297 137 63197579
Death 15.00 9.54 1949 289357 372432 62825284
Respiratory tract infection 14.99 9.54 120 291186 41363 63156353
Morose 14.96 9.54 6 291300 35 63197681
Squamous cell carcinoma of the oral cavity 14.95 9.54 12 291294 300 63197416
Psychotic behaviour 14.91 9.54 16 291290 584 63197132
Autonomic nervous system imbalance 14.83 9.54 37 291269 2781 63194935
Obesity 14.82 9.54 206 291100 29746 63167970
Tooth hypoplasia 14.80 9.54 7 291299 64 63197652
Fluid retention 14.78 9.54 189 291117 59497 63138219
Central nervous system necrosis 14.77 9.54 9 291297 142 63197574
Loss of libido 14.72 9.54 24 291282 1325 63196391
Gait disturbance 14.66 9.54 1002 290304 182176 63015540
Amnesia 14.59 9.54 346 290960 55239 63142477
Impaired work ability 14.57 9.54 37 291269 17438 63180278
Diaphragmatic rupture 14.55 9.54 11 291295 251 63197465
Transient aphasia 14.55 9.54 6 291300 38 63197678
Lymphocyte count decreased 14.53 9.54 207 291099 30050 63167666
Enthesopathy 14.46 9.54 11 291295 8603 63189113
Uveitis 14.43 9.54 22 291284 12531 63185185
Injury 14.38 9.54 439 290867 72808 63124908
Pulmonary embolism 14.37 9.54 664 290642 116020 63081696
Duodenal ulcer perforation 14.33 9.54 298 291008 86911 63110805
Drug clearance decreased 14.33 9.54 25 291281 1459 63196257
Oppositional defiant disorder 14.30 9.54 6 291300 40 63197676
Glaucoma 14.28 9.54 42 291264 18863 63178853
Secondary immunodeficiency 14.27 9.54 24 291282 1359 63196357
Bulimia nervosa 14.24 9.54 14 291292 460 63197256
Head injury 14.20 9.54 190 291116 27206 63170510
Arrhythmia 14.18 9.54 250 291056 37890 63159826
Ductus arteriosus premature closure 14.17 9.54 12 291294 324 63197392
Febrile bone marrow aplasia 14.13 9.54 8 291298 7317 63190399
Intentional product use issue 14.12 9.54 463 290843 127429 63070287
Skin exfoliation 14.09 9.54 128 291178 42974 63154742
Inappropriate schedule of product administration 14.08 9.54 366 290940 103599 63094117
Visceral congestion 14.04 9.54 12 291294 328 63197388
Cardiac failure 13.95 9.54 307 290999 88835 63108881
Extensor plantar response 13.86 9.54 23 291283 1288 63196428
Thinking abnormal 13.86 9.54 90 291216 10553 63187163
Electrocardiogram T wave abnormal 13.81 9.54 33 291273 2414 63195302
Foot operation 13.80 9.54 8 291298 7223 63190493
Suspected suicide 13.60 9.54 63 291243 6505 63191211
Pulmonary toxicity 13.55 9.54 14 291292 9441 63188275
Echopraxia 13.44 9.54 5 291301 23 63197693
Mucosal dryness 13.38 9.54 35 291271 2709 63195007
Rheumatic fever 13.25 9.54 130 291176 42981 63154735
Sleep disorder 13.23 9.54 478 290828 81088 63116628
Pruritus allergic 13.18 9.54 25 291281 1557 63196159
Antidepressant drug level below therapeutic 13.17 9.54 3 291303 0 63197716
Maximal voluntary ventilation abnormal 13.10 9.54 5 291301 25 63197691
Pupillary reflex impaired 13.09 9.54 29 291277 2018 63195698
Abdominal pain 13.08 9.54 1538 289768 291918 62905798
Device dislocation 13.06 9.54 67 291239 25638 63172078
Blood albumin increased 13.04 9.54 19 291287 950 63196766
Drug abuser 12.96 9.54 36 291270 2887 63194829
Hypernatraemia 12.92 9.54 69 291237 7540 63190176
Surgery 12.92 9.54 104 291202 35808 63161908
Congenital pneumonia 12.88 9.54 4 291302 9 63197707
Drug screen false positive 12.88 9.54 18 291288 866 63196850
Benzodiazepine drug level increased 12.80 9.54 9 291297 183 63197533
Induced abortion failed 12.73 9.54 10 291296 242 63197474
Anaphylactic reaction 12.67 9.54 220 291086 65880 63131836
Neutrophil Pelger-Huet anomaly present 12.67 9.54 7 291299 91 63197625
Vasculitis 12.67 9.54 42 291264 18167 63179549
Influenza 12.62 9.54 391 290915 108331 63089385
Labelled drug-drug interaction issue 12.57 9.54 20 291286 1081 63196635
Joint stiffness 12.55 9.54 127 291179 41742 63155974
Cerebellar haematoma 12.50 9.54 12 291294 383 63197333
Delusion of grandeur 12.49 9.54 10 291296 249 63197467
Product complaint 12.46 9.54 101 291205 12708 63185008
Acute respiratory failure 12.45 9.54 225 291081 34260 63163456
Inflammatory marker increased 12.45 9.54 8 291298 6831 63190885
Inappropriate affect 12.42 9.54 18 291288 896 63196820
Normal newborn 12.36 9.54 12 291294 8329 63189387
Live birth 12.35 9.54 68 291238 25562 63172154
Leukopenia neonatal 12.35 9.54 5 291301 30 63197686
Vulvar basal cell carcinoma 12.35 9.54 5 291301 30 63197686
Melaena 12.33 9.54 85 291221 30280 63167436
Hyperthyroidism 12.29 9.54 31 291275 14642 63183074
Parachute mitral valve 12.28 9.54 7 291299 97 63197619
Urine ketone body present 12.28 9.54 32 291274 2471 63195245
Diverticulitis 12.27 9.54 119 291187 39438 63158278
Rabbit syndrome 12.27 9.54 11 291295 321 63197395
Impaired driving ability 12.25 9.54 47 291259 4464 63193252
Arterial spasm 12.22 9.54 6 291300 60 63197656
Musculoskeletal disorder 12.15 9.54 51 291255 20593 63177123
Erysipelas 12.15 9.54 11 291295 7894 63189822
Incoherent 12.13 9.54 47 291259 4483 63193233
Soft tissue swelling 12.07 9.54 21 291285 1223 63196493
Autologous bone marrow transplantation therapy 12.07 9.54 4 291302 12 63197704
Depressive delusion 12.07 9.54 4 291302 12 63197704
Osteonecrosis of jaw 12.05 9.54 103 291203 35020 63162696
Sluggishness 12.00 9.54 52 291254 5217 63192499
Adverse event 11.96 9.54 228 291078 67331 63130385
Tachyphylaxis 11.93 9.54 10 291296 266 63197450
Cognitive disorder 11.90 9.54 338 290968 55477 63142239
Therapy non-responder 11.87 9.54 443 290863 75458 63122258
Pleural adhesion 11.85 9.54 7 291299 104 63197612
Cardiac failure congestive 11.84 9.54 328 290978 92105 63105611
Hypoprolactinaemia 11.83 9.54 4 291302 13 63197703
Tachyphrenia 11.80 9.54 22 291284 1352 63196364
Hepatitis 11.80 9.54 121 291185 39667 63158049
Rhinalgia 11.78 9.54 24 291282 1575 63196141
Nephrogenic diabetes insipidus 11.76 9.54 18 291288 941 63196775
Water intoxication 11.71 9.54 12 291294 415 63197301
Acute respiratory distress syndrome 11.70 9.54 162 291144 23372 63174344
Cyanosis 11.66 9.54 124 291182 16811 63180905
Device breakage 11.63 9.54 22 291284 11520 63186196
Vasoconstriction 11.60 9.54 14 291292 582 63197134
Scleritis 11.58 9.54 3 291303 4425 63193291
Differential white blood cell count abnormal 11.45 9.54 16 291290 770 63196946
Neoplasm malignant 11.44 9.54 85 291221 29776 63167940
Kluver-Bucy syndrome 11.39 9.54 4 291302 15 63197701
Hypersexuality 11.39 9.54 13 291293 509 63197207
Stereotypy 11.36 9.54 12 291294 430 63197286
Partial seizures 11.34 9.54 55 291251 5787 63191929
Left ventricle outflow tract obstruction 11.32 9.54 10 291296 286 63197430
Drug screen negative 11.32 9.54 10 291296 286 63197430
Injection site warmth 11.31 9.54 34 291272 15161 63182555
Biliary tract infection 11.30 9.54 15 291291 687 63197029
Anion gap increased 11.29 9.54 26 291280 1856 63195860
Brain oedema 11.25 9.54 107 291199 14088 63183628
Polydipsia 11.25 9.54 39 291267 3525 63194191
Natural killer cell count 11.19 9.54 4 291302 16 63197700
Amegakaryocytic thrombocytopenia 11.19 9.54 4 291302 16 63197700
Maternal exposure before pregnancy 11.19 9.54 11 291295 7592 63190124
Blood lactic acid increased 11.19 9.54 63 291243 7023 63190693
Hypercapnia 11.17 9.54 52 291254 5379 63192337
Antidepressant drug level decreased 11.10 9.54 3 291303 3 63197713
Patient restraint 11.10 9.54 3 291303 3 63197713
Anti-neuronal antibody positive 11.10 9.54 3 291303 3 63197713
Benzodiazepine drug level 11.10 9.54 3 291303 3 63197713
Increased appetite 11.09 9.54 79 291227 9551 63188165
Blood creatine increased 11.06 9.54 53 291253 5548 63192168
Non-small cell lung cancer 11.06 9.54 39 291267 3556 63194160
Incision site complication 11.05 9.54 14 291292 612 63197104
Osteoradionecrosis 11.04 9.54 7 291299 119 63197597
Toxicologic test abnormal 10.98 9.54 15 291291 706 63197010
Fear of injection 10.97 9.54 10 291296 7154 63190562
Drug resistance 10.97 9.54 61 291245 22872 63174844
Pathogen resistance 10.96 9.54 8 291298 6390 63191326
Hallucination, tactile 10.95 9.54 10 291296 299 63197417
Pressure of speech 10.90 9.54 15 291291 711 63197005
Vision blurred 10.87 9.54 521 290785 91403 63106313
Carbohydrate antigen 125 increased 10.87 9.54 33 291273 2783 63194933
Dysmetropsia 10.86 9.54 6 291300 78 63197638
Stillbirth 10.85 9.54 9 291297 6741 63190975
Device adhesion issue 10.83 9.54 5 291301 5136 63192580
Hyponatriuria 10.82 9.54 4 291302 18 63197698
Red cell distribution width increased 10.80 9.54 84 291222 10440 63187276
Cerebral atrophy 10.79 9.54 49 291257 5017 63192699
Systolic hypertension 10.78 9.54 12 291294 457 63197259
Antidepressant drug level increased 10.76 9.54 10 291296 306 63197410
Tuberculosis 10.76 9.54 22 291284 11189 63186527
Clonus 10.75 9.54 46 291260 4590 63193126
Hyponatraemic syndrome 10.74 9.54 13 291293 542 63197174
Sneezing 10.73 9.54 45 291261 18173 63179543
Regressive behaviour 10.72 9.54 8 291298 179 63197537
Hypoaesthesia oral 10.71 9.54 99 291207 12934 63184782
Troponin T increased 10.67 9.54 20 291286 1234 63196482
Delusional perception 10.66 9.54 9 291297 242 63197474
Cardiovascular disorder 10.65 9.54 24 291282 11788 63185928
Dependence 10.65 9.54 27 291279 2050 63195666
Affective ambivalence 10.65 9.54 4 291302 19 63197697
Delusional disorder, unspecified type 10.60 9.54 11 291295 386 63197330
False positive investigation result 10.58 9.54 14 291292 639 63197077
Tri-iodothyronine free decreased 10.55 9.54 10 291296 314 63197402
Drug diversion 10.52 9.54 17 291289 931 63196785
Eczema 10.51 9.54 96 291210 32195 63165521
Transplant rejection 10.47 9.54 21 291285 10759 63186957
Hepatocellular injury 10.46 9.54 78 291228 27303 63170413
Bone marrow failure 10.46 9.54 85 291221 29205 63168511
Gastric ulcer 10.41 9.54 66 291240 23971 63173745
Basophil count increased 10.40 9.54 17 291289 940 63196776
Tongue movement disturbance 10.37 9.54 10 291296 321 63197395
Limbic encephalitis 10.37 9.54 10 291296 321 63197395
Schizoaffective disorder bipolar type 10.27 9.54 7 291299 135 63197581
Abortion spontaneous complete 10.25 9.54 3 291303 5 63197711
Malignant catatonia 10.24 9.54 8 291298 192 63197524
Hypoglycaemia 10.24 9.54 204 291102 59861 63137855
C-reactive protein 10.23 9.54 47 291259 4835 63192881
Lupus-like syndrome 10.15 9.54 36 291270 15259 63182457
Intestinal strangulation 10.11 9.54 6 291300 90 63197626
Balance disorder 10.09 9.54 479 290827 83943 63113773
Adrenal insufficiency 10.09 9.54 45 291261 17870 63179846
Malnutrition 10.07 9.54 111 291195 15187 63182529
Product storage error 10.06 9.54 35 291271 14921 63182795
Drug withdrawal convulsions 10.04 9.54 21 291285 1404 63196312
Disinhibition 10.03 9.54 16 291290 867 63196849
Macrophages increased 10.02 9.54 4 291302 23 63197693
Antidepressant discontinuation syndrome 10.02 9.54 5 291301 52 63197664
Pneumonia 10.01 9.54 1895 289411 454872 62742844
Blood immunoglobulin M decreased 10.00 9.54 17 291289 971 63196745
Wound infection fungal 9.97 9.54 7 291299 142 63197574
Hypertransaminasaemia 9.94 9.54 58 291248 6551 63191165
Asthma 9.92 9.54 481 290825 127080 63070636
Injection site haemorrhage 9.90 9.54 68 291238 24246 63173470
Intestinal perforation 9.90 9.54 91 291215 11872 63185844
Morbihan disease 9.88 9.54 4 291302 24 63197692
Discoloured vomit 9.88 9.54 16 291290 878 63196838
Post-traumatic stress disorder 9.88 9.54 49 291257 5202 63192514
Klebsiella bacteraemia 9.87 9.54 23 291283 1655 63196061
Skin cancer 9.85 9.54 24 291282 11471 63186245
Parkinsonian gait 9.79 9.54 12 291294 507 63197209
Cardiac failure chronic 9.78 9.54 4 291302 4414 63193302
White blood cell count decreased 9.77 9.54 753 290553 138351 63059365
Muscle tension dysphonia 9.76 9.54 8 291298 206 63197510
Cytomegalovirus viraemia 9.76 9.54 7 291299 5642 63192074
Gastric disorder 9.75 9.54 117 291189 37252 63160464
Platelet morphology abnormal 9.75 9.54 4 291302 25 63197691
Blood magnesium decreased 9.74 9.54 98 291208 13100 63184616
Compulsions 9.73 9.54 8 291298 207 63197509
Antidepressant drug level above therapeutic 9.73 9.54 11 291295 426 63197290
Brain herniation 9.73 9.54 38 291268 3639 63194077
Verbal abuse 9.72 9.54 6 291300 97 63197619
Sarcoidosis 9.70 9.54 11 291295 7111 63190605
Gallbladder cholesterolosis 9.70 9.54 15 291291 791 63196925
Cellulitis 9.70 9.54 294 291012 81664 63116052
Ventricular arrhythmia 9.68 9.54 39 291267 3789 63193927
Culture urine positive 9.67 9.54 38 291268 3649 63194067
Gout 9.66 9.54 30 291276 13241 63184475
Rhinorrhoea 9.65 9.54 228 291078 65349 63132367
Impulsive behaviour 9.64 9.54 22 291284 1561 63196155
Drug dose omission by device 9.61 9.54 5 291301 4796 63192920
Aplastic anaemia 9.61 9.54 76 291230 9493 63188223
Road traffic accident 9.61 9.54 228 291078 36404 63161312
Dysaesthesia pharynx 9.60 9.54 7 291299 151 63197565
Drug withdrawal syndrome neonatal 9.59 9.54 26 291280 2055 63195661
Sensory loss 9.57 9.54 80 291226 10158 63187558
Synovial cyst 9.57 9.54 21 291285 10412 63187304

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sopor 859.15 10.31 579 152129 11557 34792666
Agitation 434.71 10.31 846 151862 56553 34747670
Neuroleptic malignant syndrome 433.08 10.31 460 152248 17474 34786749
Drug abuse 425.97 10.31 1168 151540 97928 34706295
Catatonia 334.77 10.31 231 152477 4794 34799429
Intentional self-injury 317.99 10.31 345 152363 13426 34790797
Bradyphrenia 301.96 10.31 213 152495 4585 34799638
Sedation 275.10 10.31 396 152312 20610 34783613
Psychotic disorder 273.22 10.31 428 152280 24024 34780199
Aggression 263.42 10.31 548 152160 38416 34765807
Completed suicide 253.99 10.31 973 151735 97195 34707028
Suicide attempt 249.21 10.31 537 152171 38579 34765644
Delirium 231.56 10.31 560 152148 43431 34760792
Somnolence 223.77 10.31 1020 151688 110096 34694127
Extrapyramidal disorder 180.73 10.31 251 152457 12629 34791594
Anxiety 170.71 10.31 872 151836 98556 34705667
Schizophrenia 169.18 10.31 199 152509 8467 34795756
Confusional state 157.13 10.31 1123 151585 143037 34661186
Hallucination, auditory 153.57 10.31 223 152485 11694 34792529
Dysarthria 137.39 10.31 398 152310 34384 34769839
Intentional overdose 136.74 10.31 461 152247 43213 34761010
Drug dependence 134.63 10.31 315 152393 23902 34780321
Drug withdrawal syndrome 134.03 10.31 279 152429 19555 34784668
Overdose 132.20 10.31 763 151945 90296 34713927
Interstitial lung disease 117.01 10.31 70 152638 65212 34739011
Restlessness 115.88 10.31 307 152401 25175 34779048
Muscle rigidity 109.07 10.31 178 152530 10340 34793883
Mental status changes 102.89 10.31 383 152325 37700 34766523
Suicidal ideation 99.94 10.31 395 152313 39993 34764230
Respiratory depression 95.46 10.31 216 152492 16029 34788194
Disorientation 94.90 10.31 340 152368 32848 34771375
Febrile neutropenia 92 10.31 958 151750 135891 34668332
Abnormal behaviour 91.26 10.31 278 152430 24691 34779532
Tachycardia 90.26 10.31 657 152051 84115 34720108
Depressed level of consciousness 89.60 10.31 398 152310 42443 34761780
Parkinsonism 86.12 10.31 139 152569 7999 34796224
Delusion 83.33 10.31 176 152532 12459 34791764
Seizure 81.64 10.31 757 151951 104100 34700123
Toxicity to various agents 80.41 10.31 1275 151433 199087 34605136
Ataxia 77.87 10.31 181 152527 13672 34790551
COVID-19 72.56 10.31 143 152565 77407 34726816
Akathisia 70.61 10.31 127 152581 7982 34796241
Joint swelling 69.47 10.31 96 152612 59794 34744429
Psychomotor hyperactivity 65.75 10.31 136 152572 9486 34794737
Bradykinesia 65.60 10.31 83 152625 3810 34800413
Withdrawal syndrome 63.82 10.31 157 152551 12298 34791925
Serotonin syndrome 62.88 10.31 211 152497 19722 34784501
Mental impairment 62.60 10.31 139 152569 10183 34794040
Sedation complication 62.43 10.31 56 152652 1721 34802502
Salivary hypersecretion 62.42 10.31 125 152583 8519 34795704
Unresponsive to stimuli 62.14 10.31 262 152446 27307 34776916
Rheumatoid arthritis 61.77 10.31 46 152662 38192 34766031
Hallucination 61.77 10.31 411 152297 51087 34753136
Product dose omission issue 61.56 10.31 291 152417 119420 34684803
Acute kidney injury 60.82 10.31 952 151756 304036 34500187
Pruritus 60.34 10.31 368 152340 141613 34662610
Speech disorder 60.16 10.31 247 152461 25439 34778784
Myelosuppression 59.77 10.31 7 152701 19258 34784965
Blood creatine phosphokinase increased 58.08 10.31 365 152343 44492 34759731
Dystonia 58.02 10.31 139 152569 10706 34793517
Granulocytopenia 57.37 10.31 103 152605 6464 34797759
Paradoxical drug reaction 57.35 10.31 72 152636 3279 34800944
Paranoia 54.45 10.31 145 152563 11923 34792300
Miosis 54.04 10.31 125 152583 9410 34794813
Anaemia 52.88 10.31 710 151998 232625 34571598
Dyskinesia 52.86 10.31 216 152492 22197 34782026
Drug interaction 52.57 10.31 1325 151383 224621 34579602
Arthralgia 52.57 10.31 482 152226 169559 34634664
Psoriasis 51.56 10.31 56 152652 38756 34765467
Needle fatigue 50.59 10.31 37 152671 844 34803379
Renal impairment 50.20 10.31 227 152481 94286 34709937
Peripheral swelling 50.14 10.31 169 152539 76372 347278