Stem definition | Drug id | CAS RN |
---|---|---|
diazepam derivatives | 1606 | 846-49-1 |
Dose | Unit | Route |
---|---|---|
2.50 | mg | O |
2.50 | mg | P |
2.50 | mg | SL |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.08 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.44 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 93 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 1.30 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 1 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.09 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 17 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Sept. 30, 1977 | FDA | VALEANT INTL |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Sopor | 1579.64 | 9.59 | 1046 | 218133 | 18782 | 46448101 |
Drug abuse | 1202.51 | 9.59 | 1485 | 217694 | 61923 | 46404960 |
Suicide attempt | 479.99 | 9.59 | 898 | 218281 | 54138 | 46412745 |
Rheumatoid arthritis | 424.15 | 9.59 | 306 | 218873 | 239909 | 46226974 |
Completed suicide | 405.65 | 9.59 | 1554 | 217625 | 144366 | 46322517 |
Intentional self-injury | 402.38 | 9.59 | 531 | 218648 | 23635 | 46443248 |
Intentional overdose | 328.08 | 9.59 | 851 | 218328 | 64093 | 46402790 |
Agitation | 319.78 | 9.59 | 764 | 218415 | 54651 | 46412232 |
Neuroleptic malignant syndrome | 308.90 | 9.59 | 318 | 218861 | 10804 | 46456079 |
Somnolence | 281.17 | 9.59 | 1464 | 217715 | 155057 | 46311826 |
Overdose | 276.55 | 9.59 | 1078 | 218101 | 100901 | 46365982 |
Coma | 251.14 | 9.59 | 721 | 218458 | 57628 | 46409255 |
Catatonia | 250.97 | 9.59 | 178 | 219001 | 3584 | 46463299 |
Bradyphrenia | 245.21 | 9.59 | 216 | 218963 | 6014 | 46460869 |
Anxiety | 241.56 | 9.59 | 1571 | 217608 | 180386 | 46286497 |
Delirium | 224.21 | 9.59 | 522 | 218657 | 36706 | 46430177 |
Drug ineffective | 192.06 | 9.59 | 2149 | 217030 | 675689 | 45791194 |
Treatment failure | 191.28 | 9.59 | 99 | 219080 | 92988 | 46373895 |
Contraindicated product administered | 164.29 | 9.59 | 85 | 219094 | 79862 | 46387021 |
Confusional state | 159.80 | 9.59 | 1290 | 217889 | 158602 | 46308281 |
Pemphigus | 152.70 | 9.59 | 17 | 219162 | 45257 | 46421626 |
Toxicity to various agents | 149.26 | 9.59 | 1585 | 217594 | 210181 | 46256702 |
Drug withdrawal syndrome | 146.66 | 9.59 | 367 | 218812 | 27017 | 46439866 |
Poisoning | 145.88 | 9.59 | 247 | 218932 | 13747 | 46453136 |
Drug intolerance | 141.52 | 9.59 | 299 | 218880 | 146750 | 46320133 |
Systemic lupus erythematosus | 128.51 | 9.59 | 73 | 219106 | 65107 | 46401776 |
Drug hypersensitivity | 125.15 | 9.59 | 654 | 218525 | 243171 | 46223712 |
Serotonin syndrome | 124.91 | 9.59 | 320 | 218859 | 23900 | 46442983 |
Psychotic disorder | 124.12 | 9.59 | 306 | 218873 | 22315 | 46444568 |
Drug dependence | 123.04 | 9.59 | 282 | 218897 | 19619 | 46447264 |
Suicidal ideation | 122.29 | 9.59 | 557 | 218622 | 55825 | 46411058 |
Mania | 116.46 | 9.59 | 194 | 218985 | 10652 | 46456231 |
Tachycardia | 113.51 | 9.59 | 829 | 218350 | 98793 | 46368090 |
Arthralgia | 104.65 | 9.59 | 1151 | 218028 | 363452 | 46103431 |
Pneumonia aspiration | 103.16 | 9.59 | 355 | 218824 | 31250 | 46435633 |
Bradykinesia | 102.26 | 9.59 | 109 | 219070 | 3857 | 46463026 |
Sedation | 100.35 | 9.59 | 285 | 218894 | 22625 | 46444258 |
Therapeutic product effect decreased | 96.40 | 9.59 | 149 | 219030 | 82452 | 46384431 |
Joint swelling | 95.26 | 9.59 | 428 | 218751 | 165645 | 46301238 |
Hand deformity | 94.42 | 9.59 | 23 | 219156 | 34551 | 46432332 |
Alopecia | 94.10 | 9.59 | 417 | 218762 | 161997 | 46304886 |
Restlessness | 92.48 | 9.59 | 297 | 218882 | 25227 | 46441656 |
Slow speech | 92.05 | 9.59 | 65 | 219114 | 1299 | 46465584 |
Disorientation | 91.73 | 9.59 | 380 | 218799 | 36538 | 46430345 |
Akathisia | 91.01 | 9.59 | 144 | 219035 | 7570 | 46459313 |
Depressed level of consciousness | 90.13 | 9.59 | 452 | 218727 | 47117 | 46419766 |
Extrapyramidal disorder | 89.71 | 9.59 | 177 | 219002 | 11091 | 46455792 |
Drug interaction | 87.87 | 9.59 | 1390 | 217789 | 201704 | 46265179 |
Hypothermia | 87.06 | 9.59 | 183 | 218996 | 12000 | 46454883 |
Arthropathy | 86.75 | 9.59 | 166 | 219013 | 84534 | 46382349 |
Injection site pain | 84.86 | 9.59 | 241 | 218938 | 106911 | 46359972 |
Hypersensitivity | 84.06 | 9.59 | 391 | 218788 | 149930 | 46316953 |
Mydriasis | 81.88 | 9.59 | 164 | 219015 | 10389 | 46456494 |
Psoriasis | 80.55 | 9.59 | 154 | 219025 | 78450 | 46388433 |
Device expulsion | 79.90 | 9.59 | 16 | 219163 | 27526 | 46439357 |
Mental status changes | 77.22 | 9.59 | 369 | 218810 | 37719 | 46429164 |
Maternal exposure during pregnancy | 76.61 | 9.59 | 237 | 218942 | 102312 | 46364571 |
Rheumatoid factor positive | 73.44 | 9.59 | 6 | 219173 | 20455 | 46446428 |
Dysarthria | 72.94 | 9.59 | 359 | 218820 | 37139 | 46429744 |
Pneumonia viral | 71.81 | 9.59 | 119 | 219060 | 6505 | 46460378 |
Respiratory depression | 71.28 | 9.59 | 164 | 219015 | 11436 | 46455447 |
Aggression | 71.21 | 9.59 | 252 | 218927 | 22492 | 46444391 |
Anti-cyclic citrullinated peptide antibody positive | 70.45 | 9.59 | 5 | 219174 | 19140 | 46447743 |
Withdrawal syndrome | 70.28 | 9.59 | 216 | 218963 | 17918 | 46448965 |
Psychomotor hyperactivity | 67.07 | 9.59 | 143 | 219036 | 9470 | 46457413 |
Muscle rigidity | 67.01 | 9.59 | 146 | 219033 | 9815 | 46457068 |
Delusion | 66.37 | 9.59 | 156 | 219023 | 11032 | 46455851 |
Swelling | 66.02 | 9.59 | 330 | 218849 | 124181 | 46342702 |
Soft tissue disorder | 65.09 | 9.59 | 89 | 219090 | 4097 | 46462786 |
Hallucination, auditory | 62.74 | 9.59 | 149 | 219030 | 10607 | 46456276 |
Mobility decreased | 62.70 | 9.59 | 118 | 219061 | 60476 | 46406407 |
Injection site erythema | 62.21 | 9.59 | 163 | 219016 | 74264 | 46392619 |
Glossodynia | 62.02 | 9.59 | 70 | 219109 | 44303 | 46422580 |
Bezoar | 61.52 | 9.59 | 52 | 219127 | 1367 | 46465516 |
Speech disorder | 60.48 | 9.59 | 332 | 218847 | 35835 | 46431048 |
Rash | 60.14 | 9.59 | 1247 | 217932 | 355265 | 46111618 |
Abnormal behaviour | 59.76 | 9.59 | 226 | 218953 | 20832 | 46446051 |
Tardive dyskinesia | 59.46 | 9.59 | 118 | 219061 | 7425 | 46459458 |
Abdominal discomfort | 59.03 | 9.59 | 441 | 218738 | 150724 | 46316159 |
Pain | 58.36 | 9.59 | 1750 | 217429 | 475198 | 45991685 |
Off label use | 58.21 | 9.59 | 1349 | 217830 | 378492 | 46088391 |
Salivary hypersecretion | 57.16 | 9.59 | 106 | 219073 | 6339 | 46460544 |
Seizure | 55.35 | 9.59 | 848 | 218331 | 122206 | 46344677 |
Respiratory arrest | 54.27 | 9.59 | 307 | 218872 | 33509 | 46433374 |
Electrocardiogram QRS complex prolonged | 53.93 | 9.59 | 94 | 219085 | 5355 | 46461528 |
Psoriatic arthropathy | 53.50 | 9.59 | 55 | 219124 | 36324 | 46430559 |
Depression | 52.98 | 9.59 | 1106 | 218073 | 168998 | 46297885 |
Insomnia | 52.90 | 9.59 | 1077 | 218102 | 163847 | 46303036 |
Status epilepticus | 52.77 | 9.59 | 165 | 219014 | 13814 | 46453069 |
Unresponsive to stimuli | 51.57 | 9.59 | 292 | 218887 | 31882 | 46435001 |
Tremor | 51.27 | 9.59 | 795 | 218384 | 114844 | 46352039 |
Therapeutic product effect incomplete | 49.99 | 9.59 | 193 | 218986 | 77960 | 46388923 |
Lower respiratory tract infection | 49.67 | 9.59 | 116 | 219063 | 54973 | 46411910 |
Paranoia | 49.53 | 9.59 | 135 | 219044 | 10462 | 46456421 |
Electrocardiogram QT prolonged | 46.84 | 9.59 | 406 | 218773 | 50919 | 46415964 |
Interstitial lung disease | 46.74 | 9.59 | 116 | 219063 | 53833 | 46413050 |
Narcotic bowel syndrome | 46.66 | 9.59 | 19 | 219160 | 113 | 46466770 |
Diabetes insipidus | 46.17 | 9.59 | 54 | 219125 | 2120 | 46464763 |
Abortion spontaneous | 45.15 | 9.59 | 85 | 219094 | 43561 | 46423322 |
Psychomotor retardation | 44.73 | 9.59 | 65 | 219114 | 3168 | 46463715 |
Hyponatraemia | 44.67 | 9.59 | 696 | 218483 | 100636 | 46366247 |
Hallucination | 44.48 | 9.59 | 393 | 218786 | 49558 | 46417325 |
Incontinence | 44.47 | 9.59 | 124 | 219055 | 9738 | 46457145 |
Hip arthroplasty | 44.02 | 9.59 | 15 | 219164 | 18097 | 46448786 |
Synovitis | 43.60 | 9.59 | 144 | 219035 | 60931 | 46405952 |
Mutism | 43.20 | 9.59 | 41 | 219138 | 1259 | 46465624 |
Schizophrenia | 42.93 | 9.59 | 112 | 219067 | 8456 | 46458427 |
Infusion related reaction | 42.04 | 9.59 | 290 | 218889 | 100918 | 46365965 |
Sinusitis | 41.89 | 9.59 | 398 | 218781 | 129370 | 46337513 |
C-reactive protein abnormal | 41.65 | 9.59 | 24 | 219155 | 21246 | 46445637 |
Injection site reaction | 41.36 | 9.59 | 103 | 219076 | 47746 | 46419137 |
Asthma | 41.21 | 9.59 | 256 | 218923 | 91286 | 46375597 |
Headache | 40.89 | 9.59 | 1833 | 217346 | 476519 | 45990364 |
Dystonia | 40.78 | 9.59 | 131 | 219048 | 11126 | 46455757 |
Tachypnoea | 40.70 | 9.59 | 154 | 219025 | 14197 | 46452686 |
Urticaria | 40.03 | 9.59 | 357 | 218822 | 117535 | 46349348 |
Nasopharyngitis | 39.83 | 9.59 | 497 | 218682 | 153501 | 46313382 |
Somatic symptom disorder | 39.79 | 9.59 | 47 | 219132 | 1865 | 46465018 |
Alcohol interaction | 39.56 | 9.59 | 53 | 219126 | 2392 | 46464491 |
Pruritus | 39.24 | 9.59 | 853 | 218326 | 241499 | 46225384 |
Injection site pruritus | 38.86 | 9.59 | 80 | 219099 | 39663 | 46427220 |
Therapeutic response decreased | 38.77 | 9.59 | 91 | 219088 | 43054 | 46423829 |
Cardiac arrest | 38.74 | 9.59 | 618 | 218561 | 89781 | 46377102 |
Hypokinesia | 38.54 | 9.59 | 129 | 219050 | 11193 | 46455690 |
Dehydration | 36.72 | 9.59 | 995 | 218184 | 158545 | 46308338 |
Stupor | 36.51 | 9.59 | 62 | 219117 | 3458 | 46463425 |
Myocardial depression | 36.13 | 9.59 | 25 | 219154 | 483 | 46466400 |
Disorganised speech | 35.89 | 9.59 | 31 | 219148 | 840 | 46466043 |
Injection site swelling | 35.49 | 9.59 | 86 | 219093 | 40241 | 46426642 |
Gastric pH decreased | 35.48 | 9.59 | 22 | 219157 | 350 | 46466533 |
Constipation | 35.43 | 9.59 | 1069 | 218110 | 173028 | 46293855 |
Drooling | 35.26 | 9.59 | 58 | 219121 | 3151 | 46463732 |
Parkinsonism | 34.92 | 9.59 | 99 | 219080 | 7849 | 46459034 |
Toxic epidermal necrolysis | 34.70 | 9.59 | 32 | 219147 | 22246 | 46444637 |
Knee arthroplasty | 34.55 | 9.59 | 36 | 219143 | 23629 | 46443254 |
Mental disorder | 34.28 | 9.59 | 201 | 218978 | 22224 | 46444659 |
Anaphylactic shock | 34.17 | 9.59 | 27 | 219152 | 20247 | 46446636 |
Pain in extremity | 34.08 | 9.59 | 939 | 218240 | 257741 | 46209142 |
Derealisation | 33.94 | 9.59 | 29 | 219150 | 774 | 46466109 |
Product dose omission issue | 33.74 | 9.59 | 572 | 218607 | 167948 | 46298935 |
Small intestinal obstruction | 33.73 | 9.59 | 158 | 219021 | 16014 | 46450869 |
Sinus tachycardia | 33.72 | 9.59 | 195 | 218984 | 21454 | 46445429 |
Hepatic enzyme increased | 33.64 | 9.59 | 235 | 218944 | 81552 | 46385331 |
Fall | 33.61 | 9.59 | 1877 | 217302 | 327220 | 46139663 |
Decorticate posture | 33.61 | 9.59 | 21 | 219158 | 339 | 46466544 |
Encephalopathy | 33.46 | 9.59 | 271 | 218908 | 33318 | 46433565 |
Cytomegalovirus infection | 33.41 | 9.59 | 22 | 219157 | 18122 | 46448761 |
Persecutory delusion | 33.38 | 9.59 | 50 | 219129 | 2505 | 46464378 |
Loss of consciousness | 31.81 | 9.59 | 698 | 218481 | 107540 | 46359343 |
Exposure during pregnancy | 31.55 | 9.59 | 340 | 218839 | 107872 | 46359011 |
Hepatic function abnormal | 31.41 | 9.59 | 72 | 219107 | 34349 | 46432534 |
Infection | 31.30 | 9.59 | 440 | 218739 | 133152 | 46333731 |
Malaise | 31.22 | 9.59 | 1255 | 217924 | 329977 | 46136906 |
Red blood cell sedimentation rate increased | 31.02 | 9.59 | 37 | 219142 | 22852 | 46444031 |
Drug use disorder | 30.82 | 9.59 | 50 | 219129 | 2685 | 46464198 |
Hypoxia | 30.54 | 9.59 | 375 | 218804 | 51463 | 46415420 |
Erythema | 30.49 | 9.59 | 479 | 218700 | 142341 | 46324542 |
Miosis | 30.31 | 9.59 | 84 | 219095 | 6573 | 46460310 |
Blister | 29.98 | 9.59 | 108 | 219071 | 44523 | 46422360 |
Coma scale abnormal | 29.91 | 9.59 | 70 | 219109 | 4936 | 46461947 |
Substance abuse | 29.08 | 9.59 | 62 | 219117 | 4105 | 46462778 |
Injection site bruising | 29.04 | 9.59 | 79 | 219100 | 35557 | 46431326 |
Bone erosion | 28.43 | 9.59 | 5 | 219174 | 9438 | 46457445 |
Brain injury | 28.40 | 9.59 | 78 | 219101 | 6072 | 46460811 |
Blood prolactin increased | 28.38 | 9.59 | 51 | 219128 | 2976 | 46463907 |
Blood pH decreased | 28.22 | 9.59 | 47 | 219132 | 2580 | 46464303 |
Panic attack | 28.13 | 9.59 | 177 | 219002 | 20065 | 46446818 |
Renal ischaemia | 28.01 | 9.59 | 23 | 219156 | 580 | 46466303 |
Hyperammonaemic encephalopathy | 27.64 | 9.59 | 40 | 219139 | 1942 | 46464941 |
Crying | 27.62 | 9.59 | 182 | 218997 | 20959 | 46445924 |
Cardiac failure | 27.61 | 9.59 | 241 | 218938 | 79707 | 46387176 |
Pancreatic fibrosis | 27.60 | 9.59 | 12 | 219167 | 86 | 46466797 |
Mood swings | 27.04 | 9.59 | 149 | 219030 | 16103 | 46450780 |
Inflammation | 26.57 | 9.59 | 128 | 219051 | 48653 | 46418230 |
Hallucinations, mixed | 26.56 | 9.59 | 57 | 219122 | 3792 | 46463091 |
Product use issue | 26.54 | 9.59 | 300 | 218879 | 94344 | 46372539 |
Granulocytopenia | 26.49 | 9.59 | 69 | 219110 | 5204 | 46461679 |
Obsessive-compulsive disorder | 26.19 | 9.59 | 51 | 219128 | 3164 | 46463719 |
Febrile neutropenia | 26.16 | 9.59 | 605 | 218574 | 94022 | 46372861 |
Feeling of despair | 26.01 | 9.59 | 37 | 219142 | 1768 | 46465115 |
Musculoskeletal stiffness | 25.79 | 9.59 | 315 | 218864 | 97678 | 46369205 |
Mouth ulceration | 25.40 | 9.59 | 55 | 219124 | 26777 | 46440106 |
Hallucination, visual | 25.28 | 9.59 | 157 | 219022 | 17716 | 46449167 |
Major depression | 25.28 | 9.59 | 79 | 219100 | 6611 | 46460272 |
C-reactive protein increased | 25.26 | 9.59 | 166 | 219013 | 58424 | 46408459 |
Skin necrosis | 24.95 | 9.59 | 5 | 219174 | 8599 | 46458284 |
Dyskinesia | 24.94 | 9.59 | 226 | 218953 | 28699 | 46438184 |
Renal impairment | 24.89 | 9.59 | 226 | 218953 | 74146 | 46392737 |
PCO2 increased | 24.74 | 9.59 | 30 | 219149 | 1224 | 46465659 |
Peripheral swelling | 24.51 | 9.59 | 560 | 218619 | 157511 | 46309372 |
Macrocytosis | 24.46 | 9.59 | 41 | 219138 | 2262 | 46464621 |
Dysphagia | 24.46 | 9.59 | 504 | 218675 | 76808 | 46390075 |
Cardio-respiratory arrest | 24.41 | 9.59 | 406 | 218773 | 59463 | 46407420 |
Aspiration | 24.37 | 9.59 | 99 | 219080 | 9432 | 46457451 |
Respiratory failure | 24.32 | 9.59 | 600 | 218579 | 94216 | 46372667 |
No adverse event | 24.23 | 9.59 | 81 | 219098 | 34150 | 46432733 |
Accidental exposure to product by child | 24.03 | 9.59 | 28 | 219151 | 1095 | 46465788 |
PO2 increased | 23.90 | 9.59 | 25 | 219154 | 865 | 46466018 |
Medication error | 23.90 | 9.59 | 236 | 218943 | 30675 | 46436208 |
Hyperreflexia | 23.63 | 9.59 | 66 | 219113 | 5188 | 46461695 |
Skin ulcer | 23.53 | 9.59 | 76 | 219103 | 32382 | 46434501 |
Bradypnoea | 23.30 | 9.59 | 47 | 219132 | 2992 | 46463891 |
Generalised tonic-clonic seizure | 22.92 | 9.59 | 211 | 218968 | 26911 | 46439972 |
Bipolar disorder | 22.88 | 9.59 | 80 | 219099 | 7097 | 46459786 |
Computerised tomogram thorax abnormal | 22.79 | 9.59 | 30 | 219149 | 1331 | 46465552 |
Wrong patient received product | 22.70 | 9.59 | 34 | 219145 | 1703 | 46465180 |
Coma scale | 22.61 | 9.59 | 9 | 219170 | 50 | 46466833 |
Oral pain | 22.54 | 9.59 | 196 | 218983 | 24601 | 46442282 |
Pneumocystis jirovecii pneumonia | 22.48 | 9.59 | 23 | 219156 | 15225 | 46451658 |
Sleep disorder | 22.38 | 9.59 | 326 | 218853 | 46469 | 46420414 |
Psychiatric decompensation | 22.38 | 9.59 | 27 | 219152 | 1096 | 46465787 |
Sacroiliitis | 22.23 | 9.59 | 38 | 219141 | 2131 | 46464752 |
Hepatocellular injury | 22.19 | 9.59 | 68 | 219111 | 29454 | 46437429 |
Angioedema | 22.15 | 9.59 | 102 | 219077 | 39240 | 46427643 |
Hypochloraemia | 22.14 | 9.59 | 35 | 219144 | 1838 | 46465045 |
Pulseless electrical activity | 22.08 | 9.59 | 79 | 219100 | 7088 | 46459795 |
Morbid thoughts | 21.74 | 9.59 | 19 | 219160 | 523 | 46466360 |
Fibromyalgia | 21.14 | 9.59 | 263 | 218916 | 36200 | 46430683 |
Osteoarthritis | 20.96 | 9.59 | 188 | 218991 | 61837 | 46405046 |
Cataract | 20.95 | 9.59 | 126 | 219053 | 45289 | 46421594 |
Drug reaction with eosinophilia and systemic symptoms | 20.85 | 9.59 | 70 | 219109 | 29478 | 46437405 |
Condition aggravated | 20.85 | 9.59 | 939 | 218240 | 244113 | 46222770 |
Electroencephalogram abnormal | 20.82 | 9.59 | 51 | 219128 | 3703 | 46463180 |
Poisoning deliberate | 20.80 | 9.59 | 83 | 219096 | 7843 | 46459040 |
Wrong drug | 20.80 | 9.59 | 11 | 219168 | 127 | 46466756 |
Drug eruption | 20.79 | 9.59 | 43 | 219136 | 21286 | 46445597 |
Dissociation | 20.72 | 9.59 | 34 | 219145 | 1843 | 46465040 |
Skin maceration | 20.62 | 9.59 | 8 | 219171 | 41 | 46466842 |
Acute psychosis | 20.55 | 9.59 | 35 | 219144 | 1957 | 46464926 |
Myocardial fibrosis | 20.52 | 9.59 | 19 | 219160 | 565 | 46466318 |
Solar urticaria | 20.47 | 9.59 | 8 | 219171 | 42 | 46466841 |
Homicidal ideation | 20.38 | 9.59 | 33 | 219146 | 1769 | 46465114 |
Communication disorder | 20.32 | 9.59 | 39 | 219140 | 2394 | 46464489 |
Femur fracture | 20.20 | 9.59 | 97 | 219082 | 36900 | 46429983 |
Withdrawal catatonia | 20.16 | 9.59 | 8 | 219171 | 44 | 46466839 |
Cardiac failure congestive | 20.15 | 9.59 | 306 | 218873 | 91444 | 46375439 |
Cognitive disorder | 20.10 | 9.59 | 263 | 218916 | 36620 | 46430263 |
Rapid eye movements sleep abnormal | 20.07 | 9.59 | 10 | 219169 | 101 | 46466782 |
Pregnancy | 20.05 | 9.59 | 63 | 219116 | 27074 | 46439809 |
Tremor neonatal | 19.98 | 9.59 | 10 | 219169 | 102 | 46466781 |
Respiratory distress | 19.72 | 9.59 | 233 | 218946 | 31683 | 46435200 |
Depersonalisation/derealisation disorder | 19.66 | 9.59 | 24 | 219155 | 986 | 46465897 |
Cerebral microhaemorrhage | 19.65 | 9.59 | 10 | 219169 | 106 | 46466777 |
Cough | 19.64 | 9.59 | 882 | 218297 | 229367 | 46237516 |
Myoclonus | 19.63 | 9.59 | 125 | 219054 | 14227 | 46452656 |
Patient uncooperative | 19.47 | 9.59 | 11 | 219168 | 146 | 46466737 |
Antipsychotic drug level increased | 19.47 | 9.59 | 45 | 219134 | 3147 | 46463736 |
Psychomotor skills impaired | 19.44 | 9.59 | 36 | 219143 | 2150 | 46464733 |
Galactorrhoea | 19.40 | 9.59 | 50 | 219129 | 3747 | 46463136 |
Cogwheel rigidity | 19.24 | 9.59 | 29 | 219150 | 1461 | 46465422 |
Neurosensory hypoacusis | 19.19 | 9.59 | 14 | 219165 | 295 | 46466588 |
Peritonitis | 19.16 | 9.59 | 43 | 219136 | 20671 | 46446212 |
Ventricular hypokinesia | 19.11 | 9.59 | 52 | 219127 | 4026 | 46462857 |
Blood bicarbonate decreased | 19.08 | 9.59 | 42 | 219137 | 2843 | 46464040 |
Mitochondrial encephalomyopathy | 19.04 | 9.59 | 6 | 219173 | 14 | 46466869 |
Acute kidney injury | 19.01 | 9.59 | 909 | 218270 | 234946 | 46231937 |
Accidental overdose | 18.97 | 9.59 | 160 | 219019 | 19906 | 46446977 |
Suicidal behaviour | 18.94 | 9.59 | 38 | 219141 | 2410 | 46464473 |
Atelectasis | 18.93 | 9.59 | 152 | 219027 | 18638 | 46448245 |
Device issue | 18.88 | 9.59 | 41 | 219138 | 19939 | 46446944 |
Multiple-drug resistance | 18.88 | 9.59 | 39 | 219140 | 2526 | 46464357 |
Wheezing | 18.84 | 9.59 | 160 | 219019 | 53226 | 46413657 |
Premature delivery | 18.68 | 9.59 | 48 | 219131 | 22021 | 46444862 |
Homicide | 18.63 | 9.59 | 16 | 219163 | 430 | 46466453 |
Failure to thrive | 18.48 | 9.59 | 71 | 219108 | 6593 | 46460290 |
Screaming | 18.39 | 9.59 | 44 | 219135 | 3147 | 46463736 |
Anaphylactic reaction | 18.38 | 9.59 | 160 | 219019 | 52952 | 46413931 |
Schizophreniform disorder | 18.20 | 9.59 | 8 | 219171 | 59 | 46466824 |
Haematotoxicity | 18.18 | 9.59 | 5 | 219174 | 6928 | 46459955 |
Therapy cessation | 18.17 | 9.59 | 64 | 219115 | 26565 | 46440318 |
Pericarditis | 18.06 | 9.59 | 55 | 219124 | 23872 | 46443011 |
Uveitis | 18.02 | 9.59 | 9 | 219170 | 8632 | 46458251 |
Lethargy | 18.00 | 9.59 | 339 | 218840 | 50832 | 46416051 |
Tracheal atresia | 17.96 | 9.59 | 6 | 219173 | 18 | 46466865 |
Neonatal behavioural syndrome | 17.87 | 9.59 | 7 | 219172 | 37 | 46466846 |
Parosmia | 17.82 | 9.59 | 51 | 219128 | 4065 | 46462818 |
Urinary retention | 17.79 | 9.59 | 194 | 218985 | 25867 | 46441016 |
Anxiety disorder | 17.70 | 9.59 | 46 | 219133 | 3465 | 46463418 |
Hypophagia | 17.69 | 9.59 | 213 | 218966 | 29093 | 46437790 |
Victim of sexual abuse | 17.67 | 9.59 | 17 | 219162 | 531 | 46466352 |
COVID-19 | 17.65 | 9.59 | 38 | 219141 | 18537 | 46448346 |
Encephalitis autoimmune | 17.63 | 9.59 | 24 | 219155 | 1100 | 46465783 |
Mood altered | 17.62 | 9.59 | 113 | 219066 | 12894 | 46453989 |
Red blood cell sedimentation rate abnormal | 17.52 | 9.59 | 23 | 219156 | 13626 | 46453257 |
Respiratory acidosis | 17.45 | 9.59 | 66 | 219113 | 6082 | 46460801 |
Drop attacks | 17.38 | 9.59 | 19 | 219160 | 692 | 46466191 |
Loss of personal independence in daily activities | 17.34 | 9.59 | 178 | 219001 | 57005 | 46409878 |
Nightmare | 17.12 | 9.59 | 135 | 219044 | 16463 | 46450420 |
Feeling jittery | 17.04 | 9.59 | 99 | 219080 | 10909 | 46455974 |
Basal cell carcinoma | 17.01 | 9.59 | 45 | 219134 | 20442 | 46446441 |
Persistent left superior vena cava | 17.00 | 9.59 | 7 | 219172 | 43 | 46466840 |
Delusion of grandeur | 16.99 | 9.59 | 10 | 219169 | 144 | 46466739 |
Haemophagocytic lymphohistiocytosis | 16.93 | 9.59 | 9 | 219170 | 8333 | 46458550 |
Tuberculosis | 16.89 | 9.59 | 14 | 219165 | 10251 | 46456632 |
Change of bowel habit | 16.85 | 9.59 | 30 | 219149 | 1738 | 46465145 |
Adverse event | 16.76 | 9.59 | 93 | 219086 | 34091 | 46432792 |
Breast cancer | 16.71 | 9.59 | 135 | 219044 | 45383 | 46421500 |
Depressed mood | 16.68 | 9.59 | 234 | 218945 | 33085 | 46433798 |
Compartment syndrome | 16.64 | 9.59 | 32 | 219147 | 1967 | 46464916 |
Ear infection | 16.60 | 9.59 | 54 | 219125 | 22959 | 46443924 |
Intentional product use issue | 16.54 | 9.59 | 163 | 219016 | 52617 | 46414266 |
Acute generalised exanthematous pustulosis | 16.52 | 9.59 | 12 | 219167 | 9393 | 46457490 |
Rhesus antigen positive | 16.50 | 9.59 | 9 | 219170 | 111 | 46466772 |
Hyperprolactinaemia | 16.44 | 9.59 | 40 | 219139 | 2892 | 46463991 |
Liver disorder | 16.32 | 9.59 | 105 | 219074 | 37141 | 46429742 |
Infective pulmonary exacerbation of cystic fibrosis | 16.27 | 9.59 | 16 | 219163 | 10791 | 46456092 |
Inappropriate affect | 16.23 | 9.59 | 20 | 219159 | 830 | 46466053 |
Osteonecrosis of jaw | 16.10 | 9.59 | 95 | 219084 | 34307 | 46432576 |
Refusal of treatment by patient | 16.10 | 9.59 | 59 | 219120 | 5356 | 46461527 |
Pallor | 16.07 | 9.59 | 173 | 219006 | 22993 | 46443890 |
Osteoporosis | 16.05 | 9.59 | 118 | 219061 | 40490 | 46426393 |
Hyperchloraemia | 16.05 | 9.59 | 18 | 219161 | 675 | 46466208 |
Atonic seizures | 15.91 | 9.59 | 17 | 219162 | 603 | 46466280 |
Behaviour disorder | 15.84 | 9.59 | 31 | 219148 | 1930 | 46464953 |
Suspected suicide attempt | 15.83 | 9.59 | 9 | 219170 | 121 | 46466762 |
Diaphragmatic rupture | 15.79 | 9.59 | 11 | 219168 | 215 | 46466668 |
Device difficult to use | 15.72 | 9.59 | 9 | 219170 | 7995 | 46458888 |
Central nervous system necrosis | 15.70 | 9.59 | 9 | 219170 | 123 | 46466760 |
Autonomic nervous system imbalance | 15.68 | 9.59 | 35 | 219144 | 2391 | 46464492 |
Hypotonia neonatal | 15.67 | 9.59 | 20 | 219159 | 860 | 46466023 |
Schizoaffective disorder | 15.62 | 9.59 | 26 | 219153 | 1426 | 46465457 |
Newborn persistent pulmonary hypertension | 15.62 | 9.59 | 8 | 219171 | 86 | 46466797 |
Inappropriate schedule of product administration | 15.61 | 9.59 | 213 | 218966 | 64800 | 46402083 |
Hypervigilance | 15.60 | 9.59 | 13 | 219166 | 335 | 46466548 |
Cardiac malposition | 15.55 | 9.59 | 7 | 219172 | 55 | 46466828 |
Alcohol use | 15.53 | 9.59 | 35 | 219144 | 2407 | 46464476 |
Apnoea | 15.52 | 9.59 | 72 | 219107 | 7267 | 46459616 |
Leukocytosis | 15.43 | 9.59 | 173 | 219006 | 23225 | 46443658 |
Anomalous pulmonary venous connection | 15.34 | 9.59 | 7 | 219172 | 57 | 46466826 |
Echolalia | 15.30 | 9.59 | 10 | 219169 | 175 | 46466708 |
Gastric ulcer | 15.29 | 9.59 | 52 | 219127 | 21811 | 46445072 |
Platelet production decreased | 15.24 | 9.59 | 4 | 219175 | 3 | 46466880 |
Blood creatine phosphokinase increased | 15.23 | 9.59 | 198 | 218981 | 27526 | 46439357 |
Respiratory alkalosis | 15.23 | 9.59 | 36 | 219143 | 2555 | 46464328 |
Lung disorder | 15.18 | 9.59 | 130 | 219049 | 43174 | 46423709 |
Visceral congestion | 15.15 | 9.59 | 12 | 219167 | 287 | 46466596 |
Device dislocation | 15.15 | 9.59 | 52 | 219127 | 21750 | 46445133 |
Morose | 14.83 | 9.59 | 6 | 219173 | 35 | 46466848 |
Glaucoma | 14.77 | 9.59 | 33 | 219146 | 15888 | 46450995 |
Squamous cell carcinoma of the oral cavity | 14.70 | 9.59 | 12 | 219167 | 300 | 46466583 |
Device use error | 14.64 | 9.59 | 3 | 219176 | 5078 | 46461805 |
Skin reaction | 14.51 | 9.59 | 18 | 219161 | 10928 | 46455955 |
Intentional product misuse | 14.50 | 9.59 | 306 | 218873 | 46822 | 46420061 |
Blood creatine increased | 14.49 | 9.59 | 51 | 219128 | 4539 | 46462344 |
Aphasia | 14.45 | 9.59 | 201 | 218978 | 28366 | 46438517 |
Impaired healing | 14.41 | 9.59 | 107 | 219072 | 36636 | 46430247 |
Bone marrow failure | 14.39 | 9.59 | 81 | 219098 | 29588 | 46437295 |
Tooth hypoplasia | 14.37 | 9.59 | 7 | 219172 | 67 | 46466816 |
Thymus disorder | 14.33 | 9.59 | 10 | 219169 | 196 | 46466687 |
Prescribed overdose | 14.29 | 9.59 | 91 | 219088 | 10358 | 46456525 |
Hypotension | 14.17 | 9.59 | 1272 | 217907 | 231317 | 46235566 |
Oppositional defiant disorder | 14.16 | 9.59 | 6 | 219173 | 40 | 46466843 |
Bronchitis | 14.10 | 9.59 | 384 | 218795 | 105595 | 46361288 |
Oxygen saturation abnormal | 14.10 | 9.59 | 36 | 219143 | 2682 | 46464201 |
Pleurothotonus | 14.09 | 9.59 | 22 | 219157 | 1143 | 46465740 |
Staring | 14.08 | 9.59 | 25 | 219154 | 1445 | 46465438 |
Disturbance in attention | 13.98 | 9.59 | 217 | 218962 | 31343 | 46435540 |
Psychotic behaviour | 13.97 | 9.59 | 16 | 219163 | 614 | 46466269 |
Affective disorder | 13.93 | 9.59 | 52 | 219127 | 4763 | 46462120 |
Wound | 13.91 | 9.59 | 131 | 219048 | 42671 | 46424212 |
H1N1 influenza | 13.91 | 9.59 | 25 | 219154 | 1459 | 46465424 |
Alcohol poisoning | 13.86 | 9.59 | 32 | 219147 | 2236 | 46464647 |
Ductus arteriosus premature closure | 13.80 | 9.59 | 12 | 219167 | 328 | 46466555 |
Renal failure | 13.75 | 9.59 | 417 | 218762 | 113177 | 46353706 |
Neutropenic sepsis | 13.64 | 9.59 | 23 | 219156 | 12301 | 46454582 |
Oedema | 13.61 | 9.59 | 227 | 218952 | 66844 | 46400039 |
Wound infection fungal | 13.61 | 9.59 | 7 | 219172 | 76 | 46466807 |
Upper respiratory tract infection | 13.60 | 9.59 | 213 | 218966 | 63343 | 46403540 |
Irritability | 13.58 | 9.59 | 201 | 218978 | 28745 | 46438138 |
Foot deformity | 13.48 | 9.59 | 33 | 219146 | 15392 | 46451491 |
Melaena | 13.37 | 9.59 | 76 | 219103 | 27696 | 46439187 |
Protein C increased | 13.37 | 9.59 | 9 | 219170 | 166 | 46466717 |
Product complaint | 13.36 | 9.59 | 100 | 219079 | 12001 | 46454882 |
Vasoconstriction | 13.35 | 9.59 | 14 | 219165 | 486 | 46466397 |
Pressure of speech | 13.32 | 9.59 | 15 | 219164 | 565 | 46466318 |
Left ventricle outflow tract obstruction | 13.26 | 9.59 | 10 | 219169 | 222 | 46466661 |
Cardiovascular disorder | 13.26 | 9.59 | 23 | 219156 | 12164 | 46454719 |
Transient aphasia | 13.24 | 9.59 | 6 | 219173 | 48 | 46466835 |
Mental impairment | 13.23 | 9.59 | 102 | 219077 | 12354 | 46454529 |
Injection site warmth | 13.23 | 9.59 | 28 | 219151 | 13744 | 46453139 |
Neutrophil Pelger-Huet anomaly present | 13.22 | 9.59 | 7 | 219172 | 81 | 46466802 |
Emotional distress | 13.17 | 9.59 | 210 | 218969 | 30497 | 46436386 |
Disease progression | 13.15 | 9.59 | 539 | 218640 | 90761 | 46376122 |
Electrocardiogram T wave abnormal | 13.15 | 9.59 | 32 | 219147 | 2314 | 46464569 |
Ataxia | 13.13 | 9.59 | 111 | 219068 | 13819 | 46453064 |
Anger | 13.12 | 9.59 | 98 | 219081 | 11754 | 46455129 |
Reaction to azo-dyes | 13.10 | 9.59 | 3 | 219176 | 0 | 46466883 |
Antidepressant drug level below therapeutic | 13.10 | 9.59 | 3 | 219176 | 0 | 46466883 |
Febrile bone marrow aplasia | 13.07 | 9.59 | 8 | 219171 | 6854 | 46460029 |
Loss of libido | 13.00 | 9.59 | 23 | 219156 | 1326 | 46465557 |
Urinary incontinence | 12.95 | 9.59 | 197 | 218982 | 28333 | 46438550 |
Toxic skin eruption | 12.92 | 9.59 | 24 | 219155 | 12363 | 46454520 |
Gastrointestinal sounds abnormal | 12.88 | 9.59 | 41 | 219138 | 3465 | 46463418 |
Gastrointestinal haemorrhage | 12.87 | 9.59 | 271 | 218908 | 77102 | 46389781 |
Phagophobia | 12.83 | 9.59 | 5 | 219174 | 26 | 46466857 |
Cerebellar haematoma | 12.82 | 9.59 | 12 | 219167 | 362 | 46466521 |
Wrong technique in product usage process | 12.82 | 9.59 | 179 | 219000 | 54243 | 46412640 |
Peritonitis bacterial | 12.81 | 9.59 | 13 | 219166 | 8640 | 46458243 |
Congenital pneumonia | 12.79 | 9.59 | 4 | 219175 | 9 | 46466874 |
Surgery | 12.69 | 9.59 | 81 | 219098 | 28704 | 46438179 |
Drug screen false positive | 12.67 | 9.59 | 18 | 219161 | 859 | 46466024 |
Carbohydrate antigen 125 increased | 12.59 | 9.59 | 32 | 219147 | 2378 | 46464505 |
Alcohol abuse | 12.57 | 9.59 | 30 | 219149 | 2142 | 46464741 |
Joint injury | 12.56 | 9.59 | 47 | 219132 | 19162 | 46447721 |
Pulmonary arterial hypertension | 12.46 | 9.59 | 71 | 219108 | 25857 | 46441026 |
Soft tissue swelling | 12.34 | 9.59 | 18 | 219161 | 880 | 46466003 |
Apathy | 12.33 | 9.59 | 67 | 219112 | 7201 | 46459682 |
Rabbit syndrome | 12.31 | 9.59 | 11 | 219168 | 312 | 46466571 |
Restless legs syndrome | 12.27 | 9.59 | 121 | 219058 | 15722 | 46451161 |
Psychotic symptom | 12.16 | 9.59 | 18 | 219161 | 892 | 46465991 |
Monocyte count decreased | 12.10 | 9.59 | 26 | 219153 | 1731 | 46465152 |
Parachute mitral valve | 12.07 | 9.59 | 7 | 219172 | 98 | 46466785 |
Balance disorder | 12.00 | 9.59 | 392 | 218787 | 64129 | 46402754 |
Depressive delusion | 11.98 | 9.59 | 4 | 219175 | 12 | 46466871 |
Autologous bone marrow transplantation therapy | 11.98 | 9.59 | 4 | 219175 | 12 | 46466871 |
Thinking abnormal | 11.93 | 9.59 | 83 | 219096 | 9731 | 46457152 |
Joint effusion | 11.85 | 9.59 | 24 | 219155 | 11971 | 46454912 |
Colitis ulcerative | 11.84 | 9.59 | 43 | 219136 | 17689 | 46449194 |
Device breakage | 11.77 | 9.59 | 17 | 219162 | 9675 | 46457208 |
Leukopenia neonatal | 11.72 | 9.59 | 5 | 219174 | 34 | 46466849 |
Impaired driving ability | 11.71 | 9.59 | 45 | 219134 | 4179 | 46462704 |
Hypoglycaemia | 11.68 | 9.59 | 182 | 218997 | 54167 | 46412716 |
Blood magnesium decreased | 11.67 | 9.59 | 90 | 219089 | 10902 | 46455981 |
Stevens-Johnson syndrome | 11.63 | 9.59 | 63 | 219116 | 23234 | 46443649 |
Pneumonia | 11.59 | 9.59 | 1569 | 217610 | 374751 | 46092132 |
Pruritus allergic | 11.55 | 9.59 | 19 | 219160 | 1032 | 46465851 |
Eczema eyelids | 11.53 | 9.59 | 7 | 219172 | 107 | 46466776 |
Immunodeficiency | 11.49 | 9.59 | 28 | 219151 | 13078 | 46453805 |
Injection site rash | 11.48 | 9.59 | 37 | 219142 | 15776 | 46451107 |
Schizoaffective disorder bipolar type | 11.42 | 9.59 | 7 | 219172 | 109 | 46466774 |
Tendonitis | 11.37 | 9.59 | 32 | 219147 | 14245 | 46452638 |
Incision site complication | 11.36 | 9.59 | 14 | 219165 | 581 | 46466302 |
Arterial spasm | 11.29 | 9.59 | 6 | 219173 | 70 | 46466813 |
Laryngeal stenosis | 11.23 | 9.59 | 15 | 219164 | 675 | 46466208 |
Haemoglobin urine | 11.20 | 9.59 | 7 | 219172 | 113 | 46466770 |
Face oedema | 11.18 | 9.59 | 49 | 219130 | 19104 | 46447779 |
Antidepressant drug level above therapeutic | 11.17 | 9.59 | 11 | 219168 | 354 | 46466529 |
Drug abuser | 11.15 | 9.59 | 37 | 219142 | 3196 | 46463687 |
Periorbital haemorrhage | 11.14 | 9.59 | 6 | 219173 | 72 | 46466811 |
Tachyphrenia | 11.12 | 9.59 | 21 | 219158 | 1273 | 46465610 |
Drug clearance decreased | 11.12 | 9.59 | 19 | 219160 | 1065 | 46465818 |
Toxicologic test abnormal | 11.08 | 9.59 | 15 | 219164 | 684 | 46466199 |
Antidepressant drug level decreased | 11.03 | 9.59 | 3 | 219176 | 3 | 46466880 |
Benzodiazepine drug level | 11.03 | 9.59 | 3 | 219176 | 3 | 46466880 |
Drug resistance | 11.03 | 9.59 | 43 | 219136 | 17325 | 46449558 |
Hypercapnia | 11.00 | 9.59 | 47 | 219132 | 4579 | 46462304 |
Pain in jaw | 11.00 | 9.59 | 121 | 219058 | 38251 | 46428632 |
Pleural adhesion | 10.99 | 9.59 | 7 | 219172 | 117 | 46466766 |
Bone density decreased | 10.98 | 9.59 | 18 | 219161 | 9734 | 46457149 |
Inflammatory marker increased | 10.98 | 9.59 | 6 | 219173 | 5469 | 46461414 |
Respiratory disorder | 10.95 | 9.59 | 79 | 219100 | 27221 | 46439662 |
Dysmetropsia | 10.93 | 9.59 | 6 | 219173 | 75 | 46466808 |
Rash pruritic | 10.93 | 9.59 | 144 | 219035 | 44071 | 46422812 |
Cellulitis | 10.88 | 9.59 | 249 | 218930 | 70039 | 46396844 |
Blood immunoglobulin M decreased | 10.88 | 9.59 | 15 | 219164 | 696 | 46466187 |
Hypotonia | 10.84 | 9.59 | 71 | 219108 | 8158 | 46458725 |
Cyclic vomiting syndrome | 10.82 | 9.59 | 5 | 219174 | 42 | 46466841 |
Live birth | 10.78 | 9.59 | 20 | 219159 | 10310 | 46456573 |
Kluver-Bucy syndrome | 10.73 | 9.59 | 4 | 219175 | 18 | 46466865 |
Water intoxication | 10.72 | 9.59 | 12 | 219167 | 449 | 46466434 |
Bulimia nervosa | 10.69 | 9.59 | 13 | 219166 | 532 | 46466351 |
Cerebral infarction | 10.69 | 9.59 | 65 | 219114 | 23301 | 46443582 |
Acute myocardial infarction | 10.68 | 9.59 | 97 | 219082 | 31827 | 46435056 |
Fluid retention | 10.61 | 9.59 | 172 | 219007 | 50874 | 46416009 |
Platelet morphology abnormal | 10.58 | 9.59 | 3 | 219176 | 4 | 46466879 |
Tachyphylaxis | 10.57 | 9.59 | 9 | 219170 | 239 | 46466644 |
Affective ambivalence | 10.56 | 9.59 | 4 | 219175 | 19 | 46466864 |
Stillbirth | 10.50 | 9.59 | 9 | 219170 | 6482 | 46460401 |
Influenza | 10.48 | 9.59 | 329 | 218850 | 88941 | 46377942 |
False positive investigation result | 10.48 | 9.59 | 13 | 219166 | 543 | 46466340 |
Discomfort | 10.46 | 9.59 | 155 | 219024 | 46515 | 46420368 |
Neuropsychiatric symptoms | 10.45 | 9.59 | 12 | 219167 | 462 | 46466421 |
Benzodiazepine drug level increased | 10.44 | 9.59 | 8 | 219171 | 182 | 46466701 |
Hypopnoea | 10.43 | 9.59 | 30 | 219149 | 2398 | 46464485 |
Dysaesthesia pharynx | 10.40 | 9.59 | 7 | 219172 | 129 | 46466754 |
Tongue movement disturbance | 10.37 | 9.59 | 8 | 219171 | 184 | 46466699 |
Respiratory fatigue | 10.34 | 9.59 | 6 | 219173 | 84 | 46466799 |
Floppy infant | 10.34 | 9.59 | 6 | 219173 | 84 | 46466799 |
Tenosynovitis | 10.34 | 9.59 | 12 | 219167 | 7503 | 46459380 |
Coeliac disease | 10.33 | 9.59 | 11 | 219168 | 7150 | 46459733 |
Impaired work ability | 10.30 | 9.59 | 28 | 219151 | 12608 | 46454275 |
Pathogen resistance | 10.30 | 9.59 | 8 | 219171 | 6052 | 46460831 |
Blunted affect | 10.29 | 9.59 | 8 | 219171 | 186 | 46466697 |
Injection site extravasation | 10.27 | 9.59 | 10 | 219169 | 6775 | 46460108 |
Depressive symptom | 10.27 | 9.59 | 33 | 219146 | 2803 | 46464080 |
Drug level increased | 10.26 | 9.59 | 132 | 219047 | 18309 | 46448574 |
Systolic hypertension | 10.26 | 9.59 | 11 | 219168 | 392 | 46466491 |
Nausea | 10.25 | 9.59 | 3486 | 215693 | 683968 | 45782915 |
Respiratory rate decreased | 10.20 | 9.59 | 35 | 219144 | 3075 | 46463808 |
Vomiting | 10.17 | 9.59 | 2336 | 216843 | 450458 | 46016425 |
Wrong strength | 10.16 | 9.59 | 5 | 219174 | 49 | 46466834 |
Neurological decompensation | 10.14 | 9.59 | 25 | 219154 | 1823 | 46465060 |
Joint stiffness | 10.13 | 9.59 | 80 | 219099 | 27028 | 46439855 |
Ankylosing spondylitis | 10.12 | 9.59 | 10 | 219169 | 6727 | 46460156 |
Incoherent | 10.09 | 9.59 | 45 | 219134 | 4467 | 46462416 |
Osteonecrosis | 10.08 | 9.59 | 75 | 219104 | 25669 | 46441214 |
Suspected suicide | 10.06 | 9.59 | 46 | 219133 | 4615 | 46462268 |
Drug diversion | 10.06 | 9.59 | 16 | 219163 | 845 | 46466038 |
Klebsiella bacteraemia | 10.00 | 9.59 | 19 | 219160 | 1157 | 46465726 |
Intestinal strangulation | 9.98 | 9.59 | 6 | 219173 | 90 | 46466793 |
Feeling of body temperature change | 9.96 | 9.59 | 43 | 219136 | 4209 | 46462674 |
Induced abortion failed | 9.91 | 9.59 | 9 | 219170 | 261 | 46466622 |
Mean cell haemoglobin increased | 9.91 | 9.59 | 26 | 219153 | 1970 | 46464913 |
Areflexia | 9.90 | 9.59 | 34 | 219145 | 2989 | 46463894 |
Coronary artery disease | 9.85 | 9.59 | 106 | 219073 | 33646 | 46433237 |
Hyponatraemic syndrome | 9.84 | 9.59 | 13 | 219166 | 579 | 46466304 |
Gallbladder cholesterolosis | 9.80 | 9.59 | 15 | 219164 | 766 | 46466117 |
Natural killer cell count | 9.79 | 9.59 | 4 | 219175 | 24 | 46466859 |
Amegakaryocytic thrombocytopenia | 9.79 | 9.59 | 4 | 219175 | 24 | 46466859 |
Patent ductus arteriosus | 9.78 | 9.59 | 40 | 219139 | 3822 | 46463061 |
Asthenia | 9.77 | 9.59 | 1632 | 217547 | 309443 | 46157440 |
Bronchiectasis | 9.76 | 9.59 | 18 | 219161 | 9298 | 46457585 |
Laryngitis | 9.76 | 9.59 | 18 | 219161 | 9298 | 46457585 |
Irregular breathing | 9.74 | 9.59 | 9 | 219170 | 267 | 46466616 |
Myocardial infarction | 9.70 | 9.59 | 367 | 218812 | 97161 | 46369722 |
Stereotypy | 9.69 | 9.59 | 11 | 219168 | 418 | 46466465 |
Bradycardia | 9.69 | 9.59 | 392 | 218787 | 65906 | 46400977 |
Antidepressant drug level increased | 9.66 | 9.59 | 9 | 219170 | 270 | 46466613 |
Forced expiratory volume decreased | 9.65 | 9.59 | 6 | 219173 | 5098 | 46461785 |
Oropharyngeal swelling | 9.65 | 9.59 | 16 | 219163 | 875 | 46466008 |
Inappropriate antidiuretic hormone secretion | 9.64 | 9.59 | 105 | 219074 | 13997 | 46452886 |
Erysipelas | 9.63 | 9.59 | 11 | 219168 | 6927 | 46459956 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Sopor | 709.61 | 10.12 | 489 | 126013 | 10502 | 29815474 |
Agitation | 395.40 | 10.12 | 770 | 125732 | 53303 | 29772673 |
Drug abuse | 356.89 | 10.12 | 951 | 125551 | 81121 | 29744855 |
Neuroleptic malignant syndrome | 340.21 | 10.12 | 381 | 126121 | 15914 | 29810062 |
Catatonia | 335.95 | 10.12 | 217 | 126285 | 4163 | 29821813 |
Intentional self-injury | 274.97 | 10.12 | 312 | 126190 | 13220 | 29812756 |
Anxiety | 238.86 | 10.12 | 878 | 125624 | 88993 | 29736983 |
Sedation | 236.59 | 10.12 | 318 | 126184 | 16055 | 29809921 |
Bradyphrenia | 231.91 | 10.12 | 166 | 126336 | 3791 | 29822185 |
Suicide attempt | 219.15 | 10.12 | 481 | 126021 | 36216 | 29789760 |
Completed suicide | 212.00 | 10.12 | 907 | 125595 | 98585 | 29727391 |
Aggression | 188.65 | 10.12 | 455 | 126047 | 36452 | 29789524 |
Delirium | 184.68 | 10.12 | 479 | 126023 | 40152 | 29785824 |
Psychotic disorder | 157.81 | 10.12 | 307 | 126195 | 21208 | 29804768 |
Somnolence | 152.76 | 10.12 | 809 | 125693 | 95954 | 29730022 |
Extrapyramidal disorder | 118.30 | 10.12 | 183 | 126319 | 10510 | 29815466 |
Schizophrenia | 116.10 | 10.12 | 166 | 126336 | 8882 | 29817094 |
Confusional state | 115.66 | 10.12 | 968 | 125534 | 133866 | 29692110 |
Intentional overdose | 113.17 | 10.12 | 409 | 126093 | 41072 | 29784904 |
Drug withdrawal syndrome | 111.86 | 10.12 | 254 | 126248 | 19555 | 29806421 |
Interstitial lung disease | 100.73 | 10.12 | 65 | 126437 | 60132 | 29765844 |
Hallucination, auditory | 95.23 | 10.12 | 158 | 126344 | 9631 | 29816345 |
Mental status changes | 86.63 | 10.12 | 348 | 126154 | 36731 | 29789245 |
Overdose | 86.32 | 10.12 | 631 | 125871 | 83706 | 29742270 |
Suicidal ideation | 86.02 | 10.12 | 341 | 126161 | 35773 | 29790203 |
Muscle rigidity | 84.65 | 10.12 | 154 | 126348 | 10107 | 29815869 |
Restlessness | 82.44 | 10.12 | 246 | 126256 | 22353 | 29803623 |
Rheumatoid arthritis | 79.79 | 10.12 | 37 | 126465 | 41160 | 29784816 |
Psoriasis | 78.05 | 10.12 | 41 | 126461 | 42465 | 29783511 |
Tachycardia | 76.76 | 10.12 | 554 | 125948 | 73185 | 29752791 |
Akathisia | 76.75 | 10.12 | 109 | 126393 | 5795 | 29820181 |
Parkinsonism | 75.69 | 10.12 | 121 | 126381 | 7148 | 29818828 |
Acute kidney injury | 71.07 | 10.12 | 777 | 125725 | 273065 | 29552911 |
Dysarthria | 65.58 | 10.12 | 279 | 126223 | 30211 | 29795765 |
Toxicity to various agents | 64.63 | 10.12 | 1079 | 125423 | 176104 | 29649872 |
Drug dependence | 64.13 | 10.12 | 217 | 126285 | 21078 | 29804898 |
Granulocytopenia | 62.59 | 10.12 | 102 | 126400 | 6124 | 29819852 |
Disorientation | 59.64 | 10.12 | 277 | 126225 | 31141 | 29794835 |
Renal impairment | 58.78 | 10.12 | 172 | 126330 | 84012 | 29741964 |
Seizure | 58.62 | 10.12 | 655 | 125847 | 97820 | 29728156 |
Unresponsive to stimuli | 57.78 | 10.12 | 243 | 126259 | 26176 | 29799800 |
Abnormal behaviour | 54.74 | 10.12 | 234 | 126268 | 25389 | 29800587 |
Depressed level of consciousness | 51.85 | 10.12 | 307 | 126195 | 37915 | 29788061 |
Psychomotor hyperactivity | 51.56 | 10.12 | 110 | 126392 | 8114 | 29817862 |
Withdrawal syndrome | 50.42 | 10.12 | 132 | 126370 | 11118 | 29814858 |
Joint swelling | 49.46 | 10.12 | 76 | 126426 | 46870 | 29779106 |
Poverty of speech | 49.33 | 10.12 | 22 | 126480 | 190 | 29825786 |
Paranoia | 46.13 | 10.12 | 120 | 126382 | 10068 | 29815908 |
Dyskinesia | 45.56 | 10.12 | 198 | 126304 | 21636 | 29804340 |
Anaemia | 45.54 | 10.12 | 612 | 125890 | 207380 | 29618596 |
Hypokinesia | 45.39 | 10.12 | 97 | 126405 | 7163 | 29818813 |
Cytomegalovirus infection | 44.70 | 10.12 | 22 | 126480 | 23652 | 29802324 |
Cardiac failure | 44.48 | 10.12 | 191 | 126311 | 83227 | 29742749 |
Speech disorder | 44.25 | 10.12 | 213 | 126289 | 24299 | 29801677 |
Delusion | 43.24 | 10.12 | 130 | 126372 | 11859 | 29814117 |
Withdrawal catatonia | 42.61 | 10.12 | 15 | 126487 | 63 | 29825913 |
Hallucination | 42.36 | 10.12 | 353 | 126149 | 48706 | 29777270 |
Stupor | 42.10 | 10.12 | 57 | 126445 | 2896 | 29823080 |
Refusal of treatment by patient | 41.88 | 10.12 | 76 | 126426 | 4977 | 29820999 |
Respiratory depression | 41.74 | 10.12 | 125 | 126377 | 11378 | 29814598 |
Product dose omission issue | 41.73 | 10.12 | 222 | 126280 | 91409 | 29734567 |
Cholestasis | 41.63 | 10.12 | 27 | 126475 | 24923 | 29801053 |
Blood creatine phosphokinase increased | 40.83 | 10.12 | 321 | 126181 | 43527 | 29782449 |
Psoriatic arthropathy | 39.57 | 10.12 | 9 | 126493 | 15752 | 29810224 |
Dystonia | 39.44 | 10.12 | 110 | 126392 | 9617 | 29816359 |
Drug ineffective | 39.42 | 10.12 | 1116 | 125386 | 339271 | 29486705 |
Myocardial infarction | 39.41 | 10.12 | 340 | 126162 | 125285 | 29700691 |
Major depression | 39.22 | 10.12 | 65 | 126437 | 3957 | 29822019 |
Psychomotor retardation | 38.69 | 10.12 | 49 | 126453 | 2330 | 29823646 |
Depression | 38.69 | 10.12 | 566 | 125936 | 89871 | 29736105 |
Treatment failure | 38.62 | 10.12 | 54 | 126448 | 34625 | 29791351 |
Hepatic function abnormal | 38.60 | 10.12 | 74 | 126428 | 41871 | 29784105 |
Hyperkalaemia | 38.42 | 10.12 | 146 | 126356 | 65864 | 29760112 |
Sinus tachycardia | 38.20 | 10.12 | 148 | 126354 | 15356 | 29810620 |
Status epilepticus | 38.01 | 10.12 | 118 | 126384 | 10954 | 29815022 |
Homicide | 37.78 | 10.12 | 33 | 126469 | 1013 | 29824963 |
Cardiac failure congestive | 37.60 | 10.12 | 206 | 126296 | 84201 | 29741775 |
Mental impairment | 36.72 | 10.12 | 104 | 126398 | 9173 | 29816803 |
Hyperammonaemic encephalopathy | 36.57 | 10.12 | 42 | 126460 | 1802 | 29824174 |
Multiple organ dysfunction syndrome | 35.93 | 10.12 | 142 | 126360 | 63345 | 29762631 |
Irritability | 35.79 | 10.12 | 192 | 126310 | 22858 | 29803118 |
Pruritus | 35.28 | 10.12 | 324 | 126178 | 117880 | 29708096 |
Visceral congestion | 34.61 | 10.12 | 24 | 126478 | 520 | 29825456 |
Bone marrow failure | 34.56 | 10.12 | 45 | 126457 | 29740 | 29796236 |
Psychotic symptom | 34.16 | 10.12 | 33 | 126469 | 1156 | 29824820 |
Diet refusal | 33.84 | 10.12 | 20 | 126482 | 325 | 29825651 |
Drug screen positive | 33.66 | 10.12 | 64 | 126438 | 4343 | 29821633 |
Antipsychotic drug level increased | 33.37 | 10.12 | 53 | 126449 | 3113 | 29822863 |
Salivary hypersecretion | 33.11 | 10.12 | 88 | 126414 | 7478 | 29818498 |
Tremor | 32.76 | 10.12 | 473 | 126029 | 74890 | 29751086 |
Treatment noncompliance | 32.43 | 10.12 | 200 | 126302 | 25053 | 29800923 |
Drug reaction with eosinophilia and systemic symptoms | 32.08 | 10.12 | 44 | 126458 | 28444 | 29797532 |
Serotonin syndrome | 31.95 | 10.12 | 155 | 126347 | 17736 | 29808240 |
Arthralgia | 31.72 | 10.12 | 394 | 126108 | 135397 | 29690579 |
Negativism | 31.58 | 10.12 | 20 | 126482 | 370 | 29825606 |
Coronary artery disease | 31.55 | 10.12 | 106 | 126396 | 49606 | 29776370 |
Acute myocardial infarction | 31.51 | 10.12 | 116 | 126386 | 52823 | 29773153 |
Peripheral swelling | 31.23 | 10.12 | 142 | 126360 | 60932 | 29765044 |
Bradykinesia | 31.23 | 10.12 | 52 | 126450 | 3178 | 29822798 |
Oropharyngeal spasm | 31.14 | 10.12 | 15 | 126487 | 157 | 29825819 |
Electrocardiogram QT prolonged | 31.01 | 10.12 | 258 | 126244 | 35577 | 29790399 |
Coma | 30.73 | 10.12 | 283 | 126219 | 40166 | 29785810 |
Pleurothotonus | 30.54 | 10.12 | 29 | 126473 | 994 | 29824982 |
Ataxia | 30.37 | 10.12 | 112 | 126390 | 11350 | 29814626 |
Oral discharge | 30.24 | 10.12 | 14 | 126488 | 133 | 29825843 |
Mutism | 29.99 | 10.12 | 25 | 126477 | 719 | 29825257 |
Impulsive behaviour | 29.65 | 10.12 | 39 | 126463 | 1926 | 29824050 |
Anaphylactic shock | 29.61 | 10.12 | 11 | 126491 | 13982 | 29811994 |
Peritonitis bacterial | 29.58 | 10.12 | 6 | 126496 | 11372 | 29814604 |
Drug withdrawal convulsions | 29.29 | 10.12 | 30 | 126472 | 1129 | 29824847 |
Lethargy | 29.27 | 10.12 | 275 | 126227 | 39244 | 29786732 |
Self-injurious ideation | 29.17 | 10.12 | 35 | 126467 | 1574 | 29824402 |
Angioedema | 28.81 | 10.12 | 64 | 126438 | 34320 | 29791656 |
Rash | 28.44 | 10.12 | 606 | 125896 | 191283 | 29634693 |
Synovitis | 27.98 | 10.12 | 4 | 126498 | 9779 | 29816197 |
Hypoglycaemia | 26.99 | 10.12 | 117 | 126385 | 50864 | 29775112 |
Dysphoria | 26.95 | 10.12 | 39 | 126463 | 2109 | 29823867 |
Incoherent | 26.88 | 10.12 | 56 | 126446 | 4062 | 29821914 |
Gastrointestinal haemorrhage | 26.52 | 10.12 | 225 | 126277 | 83221 | 29742755 |
Dyspnoea | 26.46 | 10.12 | 1145 | 125357 | 332150 | 29493826 |
Hypersensitivity | 26.22 | 10.12 | 128 | 126374 | 53900 | 29772076 |
Insomnia | 25.83 | 10.12 | 545 | 125957 | 92791 | 29733185 |
Panic attack | 25.72 | 10.12 | 88 | 126414 | 8593 | 29817383 |
Social avoidant behaviour | 24.93 | 10.12 | 44 | 126458 | 2819 | 29823157 |
Haematuria | 24.91 | 10.12 | 101 | 126401 | 44733 | 29781243 |
Contraindicated product administered | 24.47 | 10.12 | 22 | 126480 | 17209 | 29808767 |
Mental disorder | 24.36 | 10.12 | 117 | 126385 | 13332 | 29812644 |
Panic reaction | 24.25 | 10.12 | 30 | 126472 | 1393 | 29824583 |
Persecutory delusion | 24.19 | 10.12 | 37 | 126465 | 2103 | 29823873 |
Sedation complication | 23.68 | 10.12 | 23 | 126479 | 811 | 29825165 |
Parkinsonian gait | 23.64 | 10.12 | 18 | 126484 | 453 | 29825523 |
Melaena | 23.55 | 10.12 | 65 | 126437 | 32372 | 29793604 |
Cerebrovascular accident | 23.53 | 10.12 | 232 | 126270 | 83245 | 29742731 |
Hyperosmolar state | 23.05 | 10.12 | 17 | 126485 | 407 | 29825569 |
Mania | 23.05 | 10.12 | 88 | 126414 | 9066 | 29816910 |
Jaundice | 22.92 | 10.12 | 66 | 126436 | 32420 | 29793556 |
Affect lability | 22.92 | 10.12 | 47 | 126455 | 3371 | 29822605 |
Respiratory arrest | 22.88 | 10.12 | 206 | 126296 | 29052 | 29796924 |
Confabulation | 22.44 | 10.12 | 11 | 126491 | 120 | 29825856 |
Failure to thrive | 22.44 | 10.12 | 80 | 126422 | 7974 | 29818002 |
Neologism | 22.22 | 10.12 | 6 | 126496 | 7 | 29825969 |
Hallucination, visual | 22.21 | 10.12 | 130 | 126372 | 15983 | 29809993 |
Bipolar disorder | 21.96 | 10.12 | 49 | 126453 | 3727 | 29822249 |
Blood creatine phosphokinase | 21.92 | 10.12 | 9 | 126493 | 62 | 29825914 |
Urticaria | 21.79 | 10.12 | 138 | 126364 | 54468 | 29771508 |
Drug resistance | 21.77 | 10.12 | 32 | 126470 | 20101 | 29805875 |
Transplant rejection | 21.67 | 10.12 | 6 | 126496 | 9200 | 29816776 |
Priapism | 21.61 | 10.12 | 56 | 126446 | 4687 | 29821289 |
Amnesia | 21.52 | 10.12 | 176 | 126326 | 24145 | 29801831 |
Hepatocellular carcinoma | 21.29 | 10.12 | 7 | 126495 | 9603 | 29816373 |
Anaphylactic reaction | 21.13 | 10.12 | 55 | 126447 | 27927 | 29798049 |
Anger | 21.06 | 10.12 | 98 | 126404 | 11022 | 29814954 |
Alcohol withdrawal syndrome | 21.03 | 10.12 | 30 | 126472 | 1601 | 29824375 |
Pain in extremity | 21.03 | 10.12 | 333 | 126169 | 109888 | 29716088 |
Flight of ideas | 20.97 | 10.12 | 15 | 126487 | 342 | 29825634 |
Hepatocellular injury | 20.85 | 10.12 | 48 | 126454 | 25423 | 29800553 |
Drug eruption | 20.83 | 10.12 | 26 | 126476 | 17500 | 29808476 |
Schizoaffective disorder | 20.78 | 10.12 | 24 | 126478 | 1036 | 29824940 |
Paradoxical drug reaction | 20.76 | 10.12 | 39 | 126463 | 2623 | 29823353 |
COVID-19 | 20.75 | 10.12 | 27 | 126475 | 17851 | 29808125 |
Pathogen resistance | 20.72 | 10.12 | 5 | 126497 | 8405 | 29817571 |
Miosis | 20.62 | 10.12 | 76 | 126426 | 7700 | 29818276 |
Poisoning | 20.60 | 10.12 | 99 | 126403 | 11283 | 29814693 |
Cerebral infarction | 20.56 | 10.12 | 51 | 126451 | 26322 | 29799654 |
Renal disorder | 20.50 | 10.12 | 43 | 126459 | 23541 | 29802435 |
Hangover | 20.45 | 10.12 | 24 | 126478 | 1054 | 29824922 |
Drug intolerance | 20.45 | 10.12 | 110 | 126392 | 45181 | 29780795 |
Angina pectoris | 20.08 | 10.12 | 61 | 126441 | 29457 | 29796519 |
Blood sodium decreased | 20.00 | 10.12 | 125 | 126377 | 15731 | 29810245 |
Inappropriate antidiuretic hormone secretion | 19.71 | 10.12 | 98 | 126404 | 11324 | 29814652 |
Injection site pain | 19.66 | 10.12 | 64 | 126438 | 30246 | 29795730 |
Floppy infant | 19.58 | 10.12 | 9 | 126493 | 84 | 29825892 |
Therapeutic product effect incomplete | 19.57 | 10.12 | 75 | 126427 | 33759 | 29792217 |
Communication disorder | 19.40 | 10.12 | 34 | 126468 | 2166 | 29823810 |
Antipsychotic drug level decreased | 19.32 | 10.12 | 21 | 126481 | 847 | 29825129 |
Sexually inappropriate behaviour | 19.32 | 10.12 | 14 | 126488 | 326 | 29825650 |
Aspiration | 19.26 | 10.12 | 92 | 126410 | 10459 | 29815517 |
Myocardial fibrosis | 18.83 | 10.12 | 19 | 126483 | 702 | 29825274 |
Myelosuppression | 18.75 | 10.12 | 4 | 126498 | 7318 | 29818658 |
Epstein-Barr virus infection | 18.59 | 10.12 | 3 | 126499 | 6703 | 29819273 |
Multiple drug therapy | 18.36 | 10.12 | 12 | 126490 | 235 | 29825741 |
Visual acuity reduced | 18.32 | 10.12 | 24 | 126478 | 15822 | 29810154 |
Nervousness | 18.16 | 10.12 | 98 | 126404 | 11690 | 29814286 |
Lung disorder | 18.04 | 10.12 | 70 | 126432 | 31399 | 29794577 |
Dysphagia | 17.99 | 10.12 | 338 | 126164 | 56360 | 29769616 |
Diarrhoea | 17.98 | 10.12 | 1193 | 125309 | 332910 | 29493066 |
Drug interaction | 17.94 | 10.12 | 1022 | 125480 | 198546 | 29627430 |
Illusion | 17.83 | 10.12 | 19 | 126483 | 749 | 29825227 |
Rebound effect | 17.66 | 10.12 | 27 | 126475 | 1534 | 29824442 |
Oedema peripheral | 17.52 | 10.12 | 328 | 126174 | 105504 | 29720472 |
Hypoxia | 17.22 | 10.12 | 291 | 126211 | 47563 | 29778413 |
Haemophagocytic lymphohistiocytosis | 17.16 | 10.12 | 10 | 126492 | 9781 | 29816195 |
Staring | 17.14 | 10.12 | 26 | 126476 | 1467 | 29824509 |
Arthritis | 16.91 | 10.12 | 50 | 126452 | 24351 | 29801625 |
Myocarditis | 16.65 | 10.12 | 85 | 126417 | 9926 | 29816050 |
Off label use | 16.64 | 10.12 | 872 | 125630 | 248418 | 29577558 |
Affective disorder | 16.60 | 10.12 | 39 | 126463 | 3069 | 29822907 |
Drop attacks | 16.59 | 10.12 | 16 | 126486 | 559 | 29825417 |
Erythema | 16.49 | 10.12 | 229 | 126273 | 77222 | 29748754 |
Sleep disorder | 16.48 | 10.12 | 167 | 126335 | 24312 | 29801664 |
Immune reconstitution inflammatory syndrome | 16.38 | 10.12 | 9 | 126493 | 9092 | 29816884 |
Renal failure | 16.36 | 10.12 | 417 | 126085 | 128549 | 29697427 |
Loss of consciousness | 16.33 | 10.12 | 445 | 126057 | 78930 | 29747046 |
Urinary incontinence | 16.31 | 10.12 | 125 | 126377 | 16815 | 29809161 |
Loose associations | 16.26 | 10.12 | 7 | 126495 | 55 | 29825921 |
Faecaloma | 16.10 | 10.12 | 48 | 126454 | 4357 | 29821619 |
Pressure of speech | 16.08 | 10.12 | 14 | 126488 | 428 | 29825548 |
Tubulointerstitial nephritis | 16.07 | 10.12 | 32 | 126470 | 17859 | 29808117 |
Purple glove syndrome | 15.95 | 10.12 | 7 | 126495 | 58 | 29825918 |
Cerebral haemorrhage | 15.90 | 10.12 | 78 | 126424 | 32809 | 29793167 |
Oculogyric crisis | 15.86 | 10.12 | 24 | 126478 | 1351 | 29824625 |
Liver disorder | 15.86 | 10.12 | 68 | 126434 | 29654 | 29796322 |
Atrial fibrillation | 15.83 | 10.12 | 342 | 126160 | 107782 | 29718194 |
Testicular atrophy | 15.77 | 10.12 | 15 | 126487 | 515 | 29825461 |
Pyrexia | 15.58 | 10.12 | 1053 | 125449 | 293436 | 29532540 |
Colitis ulcerative | 15.55 | 10.12 | 23 | 126479 | 14411 | 29811565 |
Disturbance in attention | 15.40 | 10.12 | 152 | 126350 | 21977 | 29803999 |
Posturing | 15.40 | 10.12 | 15 | 126487 | 531 | 29825445 |
Self esteem decreased | 15.40 | 10.12 | 15 | 126487 | 531 | 29825445 |
Feelings of worthlessness | 15.33 | 10.12 | 10 | 126492 | 195 | 29825781 |
Movement disorder | 15.12 | 10.12 | 82 | 126420 | 9801 | 29816175 |
Cough | 14.95 | 10.12 | 410 | 126092 | 125232 | 29700744 |
Poor sucking reflex | 14.79 | 10.12 | 11 | 126491 | 267 | 29825709 |
Body temperature increased | 14.75 | 10.12 | 110 | 126392 | 14670 | 29811306 |
Eczema | 14.70 | 10.12 | 21 | 126481 | 13348 | 29812628 |
Infective pulmonary exacerbation of cystic fibrosis | 14.68 | 10.12 | 9 | 126493 | 8563 | 29817413 |
Prostate cancer | 14.58 | 10.12 | 52 | 126450 | 23905 | 29802071 |
Blood urea nitrogen/creatinine ratio decreased | 14.53 | 10.12 | 6 | 126496 | 42 | 29825934 |
Haematuria traumatic | 14.52 | 10.12 | 9 | 126493 | 160 | 29825816 |
Neonatal tachypnoea | 14.27 | 10.12 | 8 | 126494 | 117 | 29825859 |
Cognitive disorder | 14.26 | 10.12 | 158 | 126344 | 23532 | 29802444 |
Blood chloride abnormal | 14.25 | 10.12 | 4 | 126498 | 6 | 29825970 |
Negative thoughts | 14.14 | 10.12 | 16 | 126486 | 675 | 29825301 |
Myelodysplastic syndrome | 14.11 | 10.12 | 37 | 126465 | 18741 | 29807235 |
Obsessive-compulsive disorder | 14.09 | 10.12 | 44 | 126458 | 4097 | 29821879 |
Arthropathy | 13.98 | 10.12 | 43 | 126459 | 20684 | 29805292 |
Generalised tonic-clonic seizure | 13.95 | 10.12 | 135 | 126367 | 19416 | 29806560 |
Soliloquy | 13.94 | 10.12 | 12 | 126490 | 361 | 29825615 |
Vascular stenosis | 13.91 | 10.12 | 9 | 126493 | 173 | 29825803 |
Infection | 13.85 | 10.12 | 239 | 126263 | 77835 | 29748141 |
Bladder cancer | 13.68 | 10.12 | 11 | 126491 | 9091 | 29816885 |
Hepatic failure | 13.59 | 10.12 | 86 | 126416 | 33957 | 29792019 |
Polyneuropathy | 13.57 | 10.12 | 18 | 126484 | 11805 | 29814171 |
Adjustment disorder | 13.54 | 10.12 | 17 | 126485 | 801 | 29825175 |
Selective mutism | 13.54 | 10.12 | 6 | 126496 | 51 | 29825925 |
Neutropenic sepsis | 13.48 | 10.12 | 17 | 126485 | 11392 | 29814584 |
Fear | 13.44 | 10.12 | 85 | 126417 | 10740 | 29815236 |
Hallucination, olfactory | 13.43 | 10.12 | 9 | 126493 | 184 | 29825792 |
Periorbital pain | 13.41 | 10.12 | 3 | 126499 | 0 | 29825976 |
Hypercapnia | 13.35 | 10.12 | 41 | 126461 | 3783 | 29822193 |
Pneumonia aspiration | 13.32 | 10.12 | 229 | 126273 | 37551 | 29788425 |
Homicidal ideation | 13.26 | 10.12 | 31 | 126471 | 2432 | 29823544 |
Septic shock | 13.21 | 10.12 | 189 | 126313 | 63418 | 29762558 |
Derealisation | 13.20 | 10.12 | 14 | 126488 | 549 | 29825427 |
Pharyngeal paraesthesia | 13.19 | 10.12 | 12 | 126490 | 389 | 29825587 |
Myalgia | 13.18 | 10.12 | 236 | 126266 | 76431 | 29749545 |
Blood alkaline phosphatase decreased | 13.14 | 10.12 | 15 | 126487 | 639 | 29825337 |
Growth hormone deficiency | 13.06 | 10.12 | 9 | 126493 | 193 | 29825783 |
Pulmonary fibrosis | 12.96 | 10.12 | 30 | 126472 | 15860 | 29810116 |
Sexual dysfunction | 12.96 | 10.12 | 55 | 126447 | 5946 | 29820030 |
Mobility decreased | 12.96 | 10.12 | 61 | 126441 | 25938 | 29800038 |
Blood count abnormal | 12.95 | 10.12 | 89 | 126413 | 11563 | 29814413 |
Echolalia | 12.90 | 10.12 | 9 | 126493 | 197 | 29825779 |
Nasal congestion | 12.89 | 10.12 | 38 | 126464 | 18528 | 29807448 |
Shoshin beriberi | 12.87 | 10.12 | 6 | 126496 | 58 | 29825918 |
Haematotoxicity | 12.81 | 10.12 | 5 | 126497 | 6165 | 29819811 |
Skin ulcer | 12.79 | 10.12 | 39 | 126463 | 18810 | 29807166 |
Thrombocytopenia | 12.72 | 10.12 | 462 | 126040 | 136582 | 29689394 |
Blood prolactin increased | 12.57 | 10.12 | 22 | 126480 | 1400 | 29824576 |
Cardiac disorder | 12.47 | 10.12 | 108 | 126394 | 39785 | 29786191 |
Glycosylated haemoglobin increased | 12.45 | 10.12 | 13 | 126489 | 9478 | 29816498 |
Acute coronary syndrome | 12.43 | 10.12 | 24 | 126478 | 13549 | 29812427 |
Nephropathy toxic | 12.42 | 10.12 | 16 | 126486 | 10623 | 29815353 |
Phonophobia | 12.39 | 10.12 | 7 | 126495 | 104 | 29825872 |
Perseveration | 12.34 | 10.12 | 7 | 126495 | 105 | 29825871 |
Herpes zoster | 12.29 | 10.12 | 75 | 126427 | 29868 | 29796108 |
Victim of child abuse | 12.22 | 10.12 | 10 | 126492 | 280 | 29825696 |
Waxy flexibility | 12.16 | 10.12 | 7 | 126495 | 108 | 29825868 |
Febrile neutropenia | 12.15 | 10.12 | 559 | 125943 | 106134 | 29719842 |
Creutzfeldt-Jakob disease | 12.11 | 10.12 | 5 | 126497 | 35 | 29825941 |
Delusion of grandeur | 12.08 | 10.12 | 11 | 126491 | 357 | 29825619 |
Proteinuria | 11.98 | 10.12 | 32 | 126470 | 16113 | 29809863 |
Ureteric obstruction | 11.97 | 10.12 | 20 | 126482 | 1226 | 29824750 |
Peritonitis | 11.96 | 10.12 | 48 | 126454 | 21327 | 29804649 |
Osteonecrosis | 11.96 | 10.12 | 32 | 126470 | 16103 | 29809873 |
Respiratory acidosis | 11.93 | 10.12 | 42 | 126460 | 4160 | 29821816 |
Gingival oedema | 11.93 | 10.12 | 4 | 126498 | 14 | 29825962 |
Pneumocystis jirovecii pneumonia | 11.92 | 10.12 | 35 | 126467 | 17085 | 29808891 |
Transient acantholytic dermatosis | 11.89 | 10.12 | 6 | 126496 | 70 | 29825906 |
Tangentiality | 11.89 | 10.12 | 7 | 126495 | 113 | 29825863 |
Tuberculosis | 11.84 | 10.12 | 10 | 126492 | 8067 | 29817909 |
Pulmonary tuberculosis | 11.75 | 10.12 | 3 | 126499 | 4854 | 29821122 |
Disorganised speech | 11.73 | 10.12 | 13 | 126489 | 536 | 29825440 |
Hypomania | 11.71 | 10.12 | 28 | 126474 | 2228 | 29823748 |
Blood creatinine increased | 11.70 | 10.12 | 295 | 126207 | 91080 | 29734896 |
Neurodegenerative disorder | 11.60 | 10.12 | 9 | 126493 | 233 | 29825743 |
Injection site swelling | 11.55 | 10.12 | 12 | 126490 | 8768 | 29817208 |
Panic disorder | 11.47 | 10.12 | 19 | 126483 | 1156 | 29824820 |
Antipsychotic drug level above therapeutic | 11.40 | 10.12 | 18 | 126484 | 1052 | 29824924 |
Feeling jittery | 11.39 | 10.12 | 39 | 126463 | 3809 | 29822167 |
Congenital pulmonary valve atresia | 11.39 | 10.12 | 6 | 126496 | 77 | 29825899 |
Injection site erythema | 11.38 | 10.12 | 26 | 126476 | 13808 | 29812168 |
Anorectal operation | 11.35 | 10.12 | 3 | 126499 | 3 | 29825973 |
Blood count | 11.35 | 10.12 | 3 | 126499 | 3 | 29825973 |
Pulse pressure increased | 11.35 | 10.12 | 3 | 126499 | 3 | 29825973 |
Thought withdrawal | 11.35 | 10.12 | 3 | 126499 | 3 | 29825973 |
Pneumonia | 11.30 | 10.12 | 1238 | 125264 | 333068 | 29492908 |
Asthma | 11.28 | 10.12 | 98 | 126404 | 36076 | 29789900 |
Pancreatitis acute | 11.27 | 10.12 | 63 | 126439 | 25632 | 29800344 |
Immunosuppressant drug level increased | 11.19 | 10.12 | 3 | 126499 | 4699 | 29821277 |
Dementia with Lewy bodies | 11.15 | 10.12 | 13 | 126489 | 567 | 29825409 |
Blood uric acid abnormal | 11.13 | 10.12 | 6 | 126496 | 81 | 29825895 |
Drug monitoring procedure incorrectly performed | 11.12 | 10.12 | 8 | 126494 | 184 | 29825792 |
Device issue | 11.07 | 10.12 | 10 | 126492 | 7806 | 29818170 |
Balance disorder | 11.04 | 10.12 | 216 | 126286 | 36277 | 29789699 |
Apnoea | 11.02 | 10.12 | 54 | 126448 | 6204 | 29819772 |
Malaise | 10.93 | 10.12 | 585 | 125917 | 166377 | 29659599 |
Paediatric autoimmune neuropsychiatric disorders associated with streptococcal infection | 10.89 | 10.12 | 3 | 126499 | 4 | 29825972 |
Muscle mass | 10.88 | 10.12 | 9 | 126493 | 256 | 29825720 |
C-reactive protein abnormal | 10.86 | 10.12 | 5 | 126497 | 5588 | 29820388 |
Injection site pruritus | 10.86 | 10.12 | 5 | 126497 | 5587 | 29820389 |
Therapeutic product effect decreased | 10.83 | 10.12 | 75 | 126427 | 29001 | 29796975 |
Mydriasis | 10.81 | 10.12 | 53 | 126449 | 6090 | 29819886 |
Hyperhidrosis | 10.80 | 10.12 | 365 | 126137 | 66725 | 29759251 |
Electroencephalogram abnormal | 10.78 | 10.12 | 28 | 126474 | 2346 | 29823630 |
Grandiosity | 10.77 | 10.12 | 10 | 126492 | 333 | 29825643 |
Acute respiratory distress syndrome | 10.60 | 10.12 | 57 | 126445 | 23415 | 29802561 |
Gastric ulcer | 10.46 | 10.12 | 31 | 126471 | 15090 | 29810886 |
Head injury | 10.46 | 10.12 | 114 | 126388 | 16906 | 29809070 |
Lip swelling | 10.44 | 10.12 | 24 | 126478 | 12720 | 29813256 |
Blood potassium decreased | 10.43 | 10.12 | 112 | 126390 | 16550 | 29809426 |
Basal cell carcinoma | 10.37 | 10.12 | 34 | 126468 | 16034 | 29809942 |
Poor quality sleep | 10.36 | 10.12 | 59 | 126443 | 7182 | 29818794 |
Hypertensive crisis | 10.35 | 10.12 | 12 | 126490 | 8345 | 29817631 |
Staphylococcal infection | 10.28 | 10.12 | 80 | 126422 | 30144 | 29795832 |
Product use in unapproved indication | 10.23 | 10.12 | 235 | 126267 | 73458 | 29752518 |
Tachyphrenia | 10.21 | 10.12 | 17 | 126485 | 1039 | 29824937 |
Acute stress disorder | 10.20 | 10.12 | 7 | 126495 | 149 | 29825827 |
Thinking abnormal | 10.20 | 10.12 | 47 | 126455 | 5264 | 29820712 |
Cerebrovascular stenosis | 10.18 | 10.12 | 6 | 126496 | 97 | 29825879 |
Medical device site irritation | 10.14 | 10.12 | 3 | 126499 | 6 | 29825970 |
Assisted suicide | 10.14 | 10.12 | 3 | 126499 | 6 | 29825970 |
Echopraxia | 10.14 | 10.12 | 3 | 126499 | 6 | 29825970 |
Drug screen false positive | 10.13 | 10.12 | 14 | 126488 | 725 | 29825251 |
Source | Code | Description |
---|---|---|
ATC | N05BA06 | NERVOUS SYSTEM PSYCHOLEPTICS ANXIOLYTICS Benzodiazepine derivatives |
ATC | N05BA56 | NERVOUS SYSTEM PSYCHOLEPTICS ANXIOLYTICS Benzodiazepine derivatives |
FDA CS | M0002356 | Benzodiazepines |
FDA EPC | N0000175694 | Benzodiazepine |
MeSH PA | D018757 | GABA Modulators |
MeSH PA | D014151 | Anti-Anxiety Agents |
MeSH PA | D000927 | Anticonvulsants |
MeSH PA | D000932 | Antiemetics |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D018682 | GABA Agents |
MeSH PA | D005765 | Gastrointestinal Agents |
MeSH PA | D006993 | Hypnotics and Sedatives |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D014149 | Tranquilizing Agents |
CHEBI has role | CHEBI:35717 | sedatives |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Myoclonic seizure | indication | 37356005 | |
Atonic seizure | indication | 42365007 | |
Anxiety | indication | 48694002 | |
Absence seizure | indication | 79631006 | |
Lennox-Gastaut syndrome | indication | 230418006 | |
Status epilepticus | indication | 230456007 | DOID:1824 |
Panic disorder | indication | 371631005 | DOID:594 |
Sedation as Adjunct to Anesthesia | indication | ||
Induce Anterograde Amnesia | indication | ||
Delirium | off-label use | 2776000 | |
Alcohol withdrawal delirium | off-label use | 8635005 | |
General anesthesia | off-label use | 50697003 | |
Seizure disorder | off-label use | 128613002 | |
Alcohol withdrawal syndrome | off-label use | 191480000 | |
Insomnia | off-label use | 193462001 | |
Spasticity | off-label use | 221360009 | |
Chemotherapy-induced nausea and vomiting | off-label use | 236084000 | |
Akathisia | off-label use | 285145004 | |
Local anesthesia | off-label use | 386761002 | |
Cocaine-Associated Acute Ischemic Heart Disease | off-label use | ||
Manic Bipolar Disorder Adjunct Treatment | off-label use | ||
Sedation in Intubated Patients | off-label use | ||
Suicidal thoughts | contraindication | 6471006 | |
Hepatic encephalopathy | contraindication | 13920009 | DOID:13413 |
Alcohol intoxication | contraindication | 25702006 | |
Depressive disorder | contraindication | 35489007 | |
Acute nephropathy | contraindication | 58574008 | |
Hepatic failure | contraindication | 59927004 | |
Substance abuse | contraindication | 66214007 | |
Sleep apnea | contraindication | 73430006 | DOID:0050847 |
Decreased respiratory function | contraindication | 80954004 | |
Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Hypoalbuminemia | contraindication | 119247004 | |
Liver function tests abnormal | contraindication | 166603001 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Syncope | contraindication | 271594007 | |
Pregnancy, function | contraindication | 289908002 | |
Severe chronic obstructive pulmonary disease | contraindication | 313299006 | |
At risk for aspiration | contraindication | 371736008 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Breastfeeding (mother) | contraindication | 413712001 | |
Chronic lung disease | contraindication | 413839001 | |
Central nervous system depression | contraindication | 418072004 | |
Porphyria | contraindication | 418470004 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.09 | acidic |
pKa2 | 11.41 | acidic |
pKa3 | 0.63 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
GABA-A receptor alpha-1/beta-3/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | IC50 | 8.46 | WOMBAT-PK | CHEMBL | |||
Fatty acid-binding protein, liver | Unclassified | Ki | 4.89 | CHEMBL |
ID | Source |
---|---|
4017848 | VUID |
N0000146205 | NUI |
D00365 | KEGG_DRUG |
4017848 | VANDF |
C0024002 | UMLSCUI |
CHEBI:6539 | CHEBI |
CHEMBL580 | ChEMBL_ID |
CHEMBL399057 | ChEMBL_ID |
CHEMBL249262 | ChEMBL_ID |
D008140 | MESH_DESCRIPTOR_UI |
3958 | PUBCHEM_CID |
DB00186 | DRUGBANK_ID |
5884 | IUPHAR_LIGAND_ID |
2809 | INN_ID |
O26FZP769L | UNII |
202479 | RXNORM |
2104 | MMSL |
3795 | MMSL |
4995 | MMSL |
d00149 | MMSL |
001460 | NDDF |
19225000 | SNOMEDCT_US |
387106007 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-3532 | SOLUTION, CONCENTRATE | 2 mg | ORAL | ANDA | 19 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0770 | LIQUID | 2 mg | ORAL | ANDA | 21 sections |
Ativan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-0063 | TABLET | 0.50 mg | ORAL | NDA | 20 sections |
Ativan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-0064 | TABLET | 1 mg | ORAL | NDA | 20 sections |
Ativan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-0065 | TABLET | 2 mg | ORAL | NDA | 20 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1539 | INJECTION, SOLUTION | 4 mg | INTRAMUSCULAR | ANDA | 33 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1985 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | ANDA | 33 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-6778 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | ANDA | 33 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-6778 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | ANDA | 33 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-6779 | INJECTION, SOLUTION | 4 mg | INTRAMUSCULAR | ANDA | 33 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-6780 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | ANDA | 33 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-6781 | INJECTION, SOLUTION | 4 mg | INTRAMUSCULAR | ANDA | 33 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-0240 | TABLET | 0.50 mg | ORAL | ANDA | 20 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-0241 | TABLET | 1 mg | ORAL | ANDA | 20 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-0242 | TABLET | 2 mg | ORAL | ANDA | 20 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7805 | TABLET | 0.50 mg | ORAL | ANDA | 18 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8003 | TABLET | 0.50 mg | ORAL | ANDA | 18 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8004 | TABLET | 1 mg | ORAL | ANDA | 18 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8050 | TABLET | 2 mg | ORAL | ANDA | 18 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8075 | TABLET | 0.50 mg | ORAL | ANDA | 13 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8076 | TABLET | 1 mg | ORAL | ANDA | 13 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8077 | TABLET | 2 mg | ORAL | ANDA | 13 sections |
Ativan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6000 | INJECTION | 2 mg | INTRAMUSCULAR | NDA | 27 sections |
Ativan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6001 | INJECTION | 2 mg | INTRAMUSCULAR | NDA | 27 sections |
Ativan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6002 | INJECTION | 4 mg | INTRAMUSCULAR | NDA | 27 sections |
Ativan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6003 | INJECTION | 4 mg | INTRAMUSCULAR | NDA | 27 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6044 | INJECTION | 2 mg | INTRAMUSCULAR | NDA | 25 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6045 | INJECTION | 4 mg | INTRAMUSCULAR | NDA | 25 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6046 | INJECTION | 2 mg | INTRAMUSCULAR | NDA | 25 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6047 | INJECTION | 4 mg | INTRAMUSCULAR | NDA | 25 sections |