Stem definition | Drug id | CAS RN |
---|---|---|
diazepam derivatives | 1606 | 846-49-1 |
Dose | Unit | Route |
---|---|---|
2.50 | mg | O |
2.50 | mg | P |
2.50 | mg | SL |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.08 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.44 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 93 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 1.30 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 1 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.09 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 17 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Sept. 30, 1977 | FDA | VALEANT INTL |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Sopor | 2093.81 | 9.54 | 1291 | 290015 | 20873 | 63176843 |
Drug abuse | 1256.05 | 9.54 | 1605 | 289701 | 70913 | 63126803 |
Completed suicide | 595.15 | 9.54 | 1740 | 289566 | 143933 | 63053783 |
Suicide attempt | 565.37 | 9.54 | 1008 | 290298 | 59910 | 63137806 |
Intentional overdose | 450.86 | 9.54 | 1029 | 290277 | 73123 | 63124593 |
Somnolence | 430.75 | 9.54 | 1792 | 289514 | 176893 | 63020823 |
Neuroleptic malignant syndrome | 425.26 | 9.54 | 389 | 290917 | 11667 | 63186049 |
Intentional self-injury | 421.60 | 9.54 | 554 | 290752 | 25133 | 63172583 |
Bradyphrenia | 387.73 | 9.54 | 293 | 291013 | 6687 | 63191029 |
Agitation | 380.83 | 9.54 | 845 | 290461 | 58912 | 63138804 |
Overdose | 378.88 | 9.54 | 1276 | 290030 | 113802 | 63083914 |
Coma | 344.45 | 9.54 | 850 | 290456 | 63514 | 63134202 |
Drug ineffective | 332.57 | 9.54 | 3134 | 288172 | 1041631 | 62156085 |
Contraindicated product administered | 302.89 | 9.54 | 331 | 290975 | 217317 | 62980399 |
Delirium | 299.01 | 9.54 | 694 | 290612 | 49847 | 63147869 |
Toxicity to various agents | 280.66 | 9.54 | 2019 | 289287 | 245231 | 62952485 |
Systemic lupus erythematosus | 262.69 | 9.54 | 344 | 290962 | 208574 | 62989142 |
Drug intolerance | 252.53 | 9.54 | 661 | 290645 | 308000 | 62889716 |
Pemphigus | 250.54 | 9.54 | 284 | 291022 | 183442 | 63014274 |
Catatonia | 242.20 | 9.54 | 185 | 291121 | 4292 | 63193424 |
Arthropathy | 238.66 | 9.54 | 446 | 290860 | 234346 | 62963370 |
Joint swelling | 227.98 | 9.54 | 757 | 290549 | 326909 | 62870807 |
Alopecia | 222.55 | 9.54 | 798 | 290508 | 336738 | 62860978 |
Drug withdrawal syndrome | 220.80 | 9.54 | 425 | 290881 | 26769 | 63170947 |
Serotonin syndrome | 213.25 | 9.54 | 432 | 290874 | 28250 | 63169466 |
Treatment failure | 195.33 | 9.54 | 386 | 290920 | 198657 | 62999059 |
Suicidal ideation | 194.66 | 9.54 | 680 | 290626 | 61741 | 63135975 |
Pain | 193.57 | 9.54 | 2323 | 288983 | 738305 | 62459411 |
Drug interaction | 192.38 | 9.54 | 1747 | 289559 | 227384 | 62970332 |
Anxiety | 191.03 | 9.54 | 1675 | 289631 | 215866 | 62981850 |
Glossodynia | 181.51 | 9.54 | 340 | 290966 | 178536 | 63019180 |
Therapeutic product effect decreased | 179.94 | 9.54 | 386 | 290920 | 192801 | 63004915 |
Hand deformity | 178.28 | 9.54 | 285 | 291021 | 159172 | 63038544 |
Disorientation | 176.15 | 9.54 | 487 | 290819 | 38965 | 63158751 |
Poisoning | 174.92 | 9.54 | 262 | 291044 | 13438 | 63184278 |
Hypersensitivity | 170.43 | 9.54 | 727 | 290579 | 291958 | 62905758 |
Tachycardia | 167.85 | 9.54 | 1021 | 290285 | 117135 | 63080581 |
Arthralgia | 164.29 | 9.54 | 1747 | 289559 | 567963 | 62629753 |
Restlessness | 163.93 | 9.54 | 395 | 290911 | 29058 | 63168658 |
Swelling | 163.42 | 9.54 | 679 | 290627 | 274699 | 62923017 |
Mydriasis | 163.26 | 9.54 | 236 | 291070 | 11720 | 63185996 |
Rheumatoid arthritis | 161.96 | 9.54 | 608 | 290698 | 253211 | 62944505 |
Psychotic disorder | 161.94 | 9.54 | 362 | 290944 | 25350 | 63172366 |
Confusional state | 159.82 | 9.54 | 1723 | 289583 | 234657 | 62963059 |
Rash | 156.05 | 9.54 | 1734 | 289572 | 559137 | 62638579 |
Depressed level of consciousness | 154.35 | 9.54 | 629 | 290677 | 61449 | 63136267 |
Bradykinesia | 153.64 | 9.54 | 152 | 291154 | 5036 | 63192680 |
Pneumonia aspiration | 151.86 | 9.54 | 424 | 290882 | 34116 | 63163600 |
Respiratory depression | 151.00 | 9.54 | 245 | 291061 | 13470 | 63184246 |
Drug dependence | 150.07 | 9.54 | 341 | 290965 | 24142 | 63173574 |
Abdominal discomfort | 147.89 | 9.54 | 865 | 290441 | 320020 | 62877696 |
Synovitis | 144.65 | 9.54 | 411 | 290895 | 186507 | 63011209 |
Mania | 144.51 | 9.54 | 227 | 291079 | 12140 | 63185576 |
Akathisia | 131.45 | 9.54 | 185 | 291121 | 8961 | 63188755 |
Extrapyramidal disorder | 123.38 | 9.54 | 220 | 291086 | 13064 | 63184652 |
Maternal exposure during pregnancy | 119.36 | 9.54 | 561 | 290745 | 219501 | 62978215 |
Speech disorder | 119.28 | 9.54 | 434 | 290872 | 40195 | 63157521 |
Infusion related reaction | 111.89 | 9.54 | 664 | 290642 | 244857 | 62952859 |
Anti-cyclic citrullinated peptide antibody positive | 110.82 | 9.54 | 229 | 291077 | 115983 | 63081733 |
Febrile neutropenia | 110.12 | 9.54 | 924 | 290382 | 117525 | 63080191 |
Muscle rigidity | 110.09 | 9.54 | 193 | 291113 | 11307 | 63186409 |
Tremor | 108.16 | 9.54 | 1003 | 290303 | 131236 | 63066480 |
Delusion | 103.97 | 9.54 | 193 | 291113 | 11824 | 63185892 |
Mental status changes | 102.22 | 9.54 | 406 | 290900 | 39193 | 63158523 |
Psychomotor hyperactivity | 99.55 | 9.54 | 177 | 291129 | 10486 | 63187230 |
Wound | 98.35 | 9.54 | 400 | 290906 | 162863 | 63034853 |
Abnormal behaviour | 97.13 | 9.54 | 266 | 291040 | 21160 | 63176556 |
Hallucination, auditory | 95.13 | 9.54 | 193 | 291113 | 12631 | 63185085 |
Slow speech | 93.48 | 9.54 | 68 | 291238 | 1461 | 63196255 |
Hypothermia | 92.10 | 9.54 | 197 | 291109 | 13384 | 63184332 |
Respiratory arrest | 91.87 | 9.54 | 344 | 290962 | 32301 | 63165415 |
Aggression | 91.30 | 9.54 | 276 | 291030 | 23222 | 63174494 |
Tardive dyskinesia | 91.06 | 9.54 | 150 | 291156 | 8352 | 63189364 |
Psychomotor retardation | 90.61 | 9.54 | 100 | 291206 | 3770 | 63193946 |
Product use issue | 89.89 | 9.54 | 617 | 290689 | 219903 | 62977813 |
Hepatic enzyme increased | 89.63 | 9.54 | 552 | 290754 | 201776 | 62995940 |
Seizure | 89.14 | 9.54 | 966 | 290340 | 131668 | 63066048 |
Device expulsion | 88.82 | 9.54 | 25 | 291281 | 34897 | 63162819 |
COVID-19 | 88.70 | 9.54 | 247 | 291059 | 112856 | 63084860 |
Off label use | 88.24 | 9.54 | 2389 | 288917 | 672073 | 62525643 |
Dysarthria | 87.97 | 9.54 | 409 | 290897 | 42302 | 63155414 |
Withdrawal syndrome | 84.49 | 9.54 | 242 | 291064 | 19755 | 63177961 |
Gastric pH decreased | 83.16 | 9.54 | 49 | 291257 | 725 | 63196991 |
Derealisation | 81.39 | 9.54 | 57 | 291249 | 1151 | 63196565 |
Schizophrenia | 81.34 | 9.54 | 156 | 291150 | 9796 | 63187920 |
Mutism | 80.88 | 9.54 | 64 | 291242 | 1566 | 63196150 |
Mobility decreased | 80.62 | 9.54 | 285 | 291021 | 120874 | 63076842 |
Electrocardiogram QT prolonged | 80.45 | 9.54 | 508 | 290798 | 59022 | 63138694 |
Drug hypersensitivity | 79.00 | 9.54 | 979 | 290327 | 309708 | 62888008 |
Depression | 77.99 | 9.54 | 1301 | 290005 | 195191 | 63002525 |
Status epilepticus | 76.03 | 9.54 | 196 | 291110 | 15037 | 63182679 |
Bezoar | 75.90 | 9.54 | 60 | 291246 | 1466 | 63196250 |
Unresponsive to stimuli | 75.76 | 9.54 | 332 | 290974 | 33484 | 63164232 |
Pericarditis | 75.74 | 9.54 | 328 | 290978 | 131251 | 63066465 |
Drooling | 75.51 | 9.54 | 91 | 291215 | 3777 | 63193939 |
Therapeutic product effect incomplete | 74.29 | 9.54 | 308 | 290998 | 124748 | 63072968 |
Cogwheel rigidity | 74.26 | 9.54 | 66 | 291240 | 1904 | 63195812 |
Cardiac arrest | 74.17 | 9.54 | 699 | 290607 | 91846 | 63105870 |
Sedation | 72.96 | 9.54 | 362 | 290944 | 38447 | 63159269 |
Discomfort | 72.88 | 9.54 | 459 | 290847 | 166915 | 63030801 |
Substance abuse | 71.72 | 9.54 | 99 | 291207 | 4708 | 63193008 |
Sinus tachycardia | 71.02 | 9.54 | 259 | 291047 | 24009 | 63173707 |
Pneumonia viral | 69.50 | 9.54 | 128 | 291178 | 7794 | 63189922 |
Hallucination | 69.30 | 9.54 | 460 | 290846 | 54357 | 63143359 |
Soft tissue disorder | 68.89 | 9.54 | 93 | 291213 | 4329 | 63193387 |
Hyponatraemia | 68.82 | 9.54 | 801 | 290505 | 111099 | 63086617 |
Injection site pain | 68.51 | 9.54 | 334 | 290972 | 129466 | 63068250 |
Dehydration | 68.12 | 9.54 | 1146 | 290160 | 172208 | 63025508 |
Incontinence | 67.96 | 9.54 | 159 | 291147 | 11473 | 63186243 |
Salivary hypersecretion | 67.43 | 9.54 | 124 | 291182 | 7542 | 63190174 |
Rheumatoid factor positive | 65.67 | 9.54 | 185 | 291121 | 84221 | 63113495 |
Injection site erythema | 64.94 | 9.54 | 182 | 291124 | 82992 | 63114724 |
Dissociation | 64.19 | 9.54 | 73 | 291233 | 2846 | 63194870 |
Paranoia | 63.23 | 9.54 | 155 | 291151 | 11524 | 63186192 |
Electrocardiogram QRS complex prolonged | 62.57 | 9.54 | 104 | 291202 | 5834 | 63191882 |
Psoriasis | 62.32 | 9.54 | 198 | 291108 | 86759 | 63110957 |
Dystonia | 62.08 | 9.54 | 171 | 291135 | 13648 | 63184068 |
Mental disorder | 60.77 | 9.54 | 258 | 291048 | 25661 | 63172055 |
Sinusitis | 60.70 | 9.54 | 706 | 290600 | 225947 | 62971769 |
Infection | 59.39 | 9.54 | 719 | 290587 | 228454 | 62969262 |
Feeling of despair | 59.24 | 9.54 | 63 | 291243 | 2276 | 63195440 |
Brain injury | 58.30 | 9.54 | 111 | 291195 | 6932 | 63190784 |
Hypoxia | 56.36 | 9.54 | 468 | 290838 | 59324 | 63138392 |
Hypokinesia | 56.33 | 9.54 | 166 | 291140 | 13770 | 63183946 |
Pruritus | 56.17 | 9.54 | 1247 | 290059 | 360206 | 62837510 |
Loss of consciousness | 55.97 | 9.54 | 806 | 290500 | 117315 | 63080401 |
Depersonalisation/derealisation disorder | 55.81 | 9.54 | 48 | 291258 | 1324 | 63196392 |
Persecutory delusion | 55.05 | 9.54 | 66 | 291240 | 2724 | 63194992 |
Computerised tomogram thorax abnormal | 54.72 | 9.54 | 53 | 291253 | 1710 | 63196006 |
Narcotic bowel syndrome | 54.49 | 9.54 | 22 | 291284 | 131 | 63197585 |
Stupor | 53.49 | 9.54 | 81 | 291225 | 4194 | 63193522 |
Peripheral swelling | 53.44 | 9.54 | 878 | 290428 | 265064 | 62932652 |
Product dose omission issue | 53.42 | 9.54 | 755 | 290551 | 233558 | 62964158 |
Interstitial lung disease | 53.27 | 9.54 | 129 | 291177 | 61779 | 63135937 |
Myelosuppression | 53.23 | 9.54 | 21 | 291285 | 23682 | 63174034 |
Hallucinations, mixed | 52.80 | 9.54 | 86 | 291220 | 4743 | 63192973 |
Hallucination, visual | 52.35 | 9.54 | 201 | 291105 | 19097 | 63178619 |
Blister | 51.00 | 9.54 | 367 | 290939 | 129447 | 63068269 |
Cardio-respiratory arrest | 50.61 | 9.54 | 458 | 290848 | 59501 | 63138215 |
Computerised tomogram thorax | 49.75 | 9.54 | 29 | 291277 | 420 | 63197296 |
H1N1 influenza | 49.74 | 9.54 | 50 | 291256 | 1689 | 63196027 |
Alcohol interaction | 49.21 | 9.54 | 58 | 291248 | 2351 | 63195365 |
Nasopharyngitis | 48.93 | 9.54 | 846 | 290460 | 253411 | 62944305 |
Dyskinesia | 48.90 | 9.54 | 282 | 291024 | 31720 | 63165996 |
Coma scale abnormal | 48.70 | 9.54 | 86 | 291220 | 5067 | 63192649 |
Multiple-drug resistance | 48.49 | 9.54 | 86 | 291220 | 5084 | 63192632 |
Therapeutic response decreased | 48.49 | 9.54 | 134 | 291172 | 61391 | 63136325 |
Respiratory failure | 48.24 | 9.54 | 695 | 290611 | 101163 | 63096553 |
Diabetes insipidus | 46.80 | 9.54 | 59 | 291247 | 2566 | 63195150 |
Erythema | 45.67 | 9.54 | 551 | 290755 | 175200 | 63022516 |
Injection site reaction | 44.26 | 9.54 | 130 | 291176 | 58394 | 63139322 |
Skin necrosis | 43.81 | 9.54 | 6 | 291300 | 13944 | 63183772 |
Fall | 43.76 | 9.54 | 2210 | 289096 | 390124 | 62807592 |
C-reactive protein increased | 43.68 | 9.54 | 255 | 291051 | 94452 | 63103264 |
Condition aggravated | 43.66 | 9.54 | 1460 | 289846 | 400757 | 62796959 |
Headache | 42.89 | 9.54 | 2423 | 288883 | 630818 | 62566898 |
Lower respiratory tract infection | 42.82 | 9.54 | 394 | 290912 | 131913 | 63065803 |
Miosis | 42.40 | 9.54 | 100 | 291206 | 7253 | 63190463 |
Injection site pruritus | 41.24 | 9.54 | 91 | 291215 | 45025 | 63152691 |
Panic attack | 41.05 | 9.54 | 207 | 291099 | 22124 | 63175592 |
Red blood cell sedimentation rate increased | 40.79 | 9.54 | 88 | 291218 | 43894 | 63153822 |
Hypertonia | 40.77 | 9.54 | 75 | 291231 | 4562 | 63193154 |
Mood swings | 40.75 | 9.54 | 179 | 291127 | 18069 | 63179647 |
Psoriatic arthropathy | 40.32 | 9.54 | 250 | 291056 | 91270 | 63106446 |
Cytomegalovirus infection | 40.25 | 9.54 | 23 | 291283 | 20929 | 63176787 |
Compartment syndrome | 40.18 | 9.54 | 51 | 291255 | 2233 | 63195483 |
Alcohol abuse | 39.48 | 9.54 | 49 | 291257 | 2097 | 63195619 |
Hypotension | 39.44 | 9.54 | 1577 | 289729 | 271027 | 62926689 |
Osmolar gap increased | 39.39 | 9.54 | 16 | 291290 | 97 | 63197619 |
Encephalitis autoimmune | 39.37 | 9.54 | 41 | 291265 | 1445 | 63196271 |
Disorganised speech | 39.21 | 9.54 | 38 | 291268 | 1227 | 63196489 |
Hyperreflexia | 39.00 | 9.54 | 85 | 291221 | 5849 | 63191867 |
Pain in extremity | 38.89 | 9.54 | 1191 | 290115 | 330295 | 62867421 |
Crying | 38.52 | 9.54 | 210 | 291096 | 23133 | 63174583 |
Somatic symptom disorder | 38.51 | 9.54 | 54 | 291252 | 2606 | 63195110 |
Apnoea | 37.77 | 9.54 | 101 | 291205 | 7921 | 63189795 |
Insomnia | 37.38 | 9.54 | 1271 | 290035 | 213981 | 62983735 |
Decorticate posture | 37.15 | 9.54 | 21 | 291285 | 286 | 63197430 |
Myocardial depression | 36.83 | 9.54 | 25 | 291281 | 479 | 63197237 |
Emotional disorder | 36.82 | 9.54 | 140 | 291166 | 13239 | 63184477 |
Newborn persistent pulmonary hypertension | 36.59 | 9.54 | 19 | 291287 | 216 | 63197500 |
Tachypnoea | 36.59 | 9.54 | 167 | 291139 | 17135 | 63180581 |
Small intestinal obstruction | 36.58 | 9.54 | 174 | 291132 | 18163 | 63179553 |
Myoclonus | 36.46 | 9.54 | 157 | 291149 | 15711 | 63182005 |
Mental impairment | 36.44 | 9.54 | 145 | 291161 | 14006 | 63183710 |
Urinary retention | 35.74 | 9.54 | 250 | 291056 | 30051 | 63167665 |
Poisoning deliberate | 35.63 | 9.54 | 123 | 291183 | 11095 | 63186621 |
Deep vein thrombosis postoperative | 35.54 | 9.54 | 124 | 291182 | 11245 | 63186471 |
Change of bowel habit | 35.51 | 9.54 | 47 | 291259 | 2146 | 63195570 |
Nicotine dependence | 35.25 | 9.54 | 28 | 291278 | 689 | 63197027 |
Drug eruption | 35.24 | 9.54 | 48 | 291258 | 28646 | 63169070 |
Propofol infusion syndrome | 35.21 | 9.54 | 32 | 291274 | 951 | 63196765 |
Respiratory acidosis | 35.17 | 9.54 | 88 | 291218 | 6627 | 63191089 |
Injection site swelling | 35.01 | 9.54 | 107 | 291199 | 47465 | 63150251 |
Abortion spontaneous | 34.84 | 9.54 | 106 | 291200 | 47089 | 63150627 |
Oral pain | 34.52 | 9.54 | 236 | 291070 | 28158 | 63169558 |
Loss of personal independence in daily activities | 34.46 | 9.54 | 283 | 291023 | 97007 | 63100709 |
Victim of sexual abuse | 34.25 | 9.54 | 27 | 291279 | 657 | 63197059 |
Psychiatric decompensation | 34.19 | 9.54 | 37 | 291269 | 1364 | 63196352 |
Blood prolactin increased | 33.80 | 9.54 | 59 | 291247 | 3444 | 63194272 |
Red blood cell sedimentation rate abnormal | 33.54 | 9.54 | 25 | 291281 | 19757 | 63177959 |
Atelectasis | 33.27 | 9.54 | 190 | 291116 | 21293 | 63176423 |
Knee arthroplasty | 33.12 | 9.54 | 132 | 291174 | 54074 | 63143642 |
Dysphagia | 33.09 | 9.54 | 581 | 290725 | 88004 | 63109712 |
Patient uncooperative | 32.61 | 9.54 | 17 | 291289 | 195 | 63197521 |
Mouth ulceration | 32.27 | 9.54 | 64 | 291242 | 32920 | 63164796 |
PO2 increased | 32.24 | 9.54 | 29 | 291277 | 850 | 63196866 |
Basal cell carcinoma | 32.23 | 9.54 | 49 | 291257 | 27942 | 63169774 |
Parosmia | 32.16 | 9.54 | 81 | 291225 | 6125 | 63191591 |
Anaphylactic shock | 31.66 | 9.54 | 37 | 291269 | 23596 | 63174120 |
Encephalopathy | 31.07 | 9.54 | 292 | 291014 | 38328 | 63159388 |
Lip dry | 31.01 | 9.54 | 147 | 291159 | 15323 | 63182393 |
Blood pH decreased | 30.94 | 9.54 | 48 | 291258 | 2539 | 63195177 |
Pulseless electrical activity | 30.79 | 9.54 | 90 | 291216 | 7431 | 63190285 |
Asthenia | 30.39 | 9.54 | 2096 | 289210 | 381508 | 62816208 |
Disturbance in attention | 30.35 | 9.54 | 288 | 291018 | 37901 | 63159815 |
Exposure during pregnancy | 30.07 | 9.54 | 517 | 290789 | 155030 | 63042686 |
Nightmare | 29.89 | 9.54 | 170 | 291136 | 19024 | 63178692 |
Feeling of body temperature change | 29.77 | 9.54 | 68 | 291238 | 4829 | 63192887 |
CSF oligoclonal band present | 29.61 | 9.54 | 20 | 291286 | 380 | 63197336 |
Renal ischaemia | 29.59 | 9.54 | 24 | 291282 | 609 | 63197107 |
Aspiration | 29.41 | 9.54 | 113 | 291193 | 10738 | 63186978 |
Cataract | 29.40 | 9.54 | 148 | 291158 | 56905 | 63140811 |
Facet joint syndrome | 29.37 | 9.54 | 122 | 291184 | 12016 | 63185700 |
Electroencephalogram abnormal | 29.32 | 9.54 | 57 | 291249 | 3615 | 63194101 |
Wrong patient received product | 29.31 | 9.54 | 43 | 291263 | 2164 | 63195552 |
Myocardial reperfusion injury | 29.29 | 9.54 | 13 | 291293 | 101 | 63197615 |
Joint injury | 29.26 | 9.54 | 57 | 291249 | 29515 | 63168201 |
Blood creatine phosphokinase increased | 29.11 | 9.54 | 239 | 291067 | 30191 | 63167525 |
Musculoskeletal stiffness | 28.88 | 9.54 | 636 | 290670 | 183982 | 63013734 |
Lethargy | 28.87 | 9.54 | 388 | 290918 | 55619 | 63142097 |
Breast cancer female | 28.86 | 9.54 | 13 | 291293 | 13546 | 63184170 |
Hypotonia neonatal | 28.83 | 9.54 | 32 | 291274 | 1214 | 63196502 |
Generalised tonic-clonic seizure | 28.35 | 9.54 | 229 | 291077 | 28787 | 63168929 |
Intentional product misuse | 28.17 | 9.54 | 414 | 290892 | 60503 | 63137213 |
Skin ulcer | 28.12 | 9.54 | 102 | 291204 | 42943 | 63154773 |
Feeling jittery | 28.07 | 9.54 | 129 | 291177 | 13274 | 63184442 |
Bradycardia | 27.96 | 9.54 | 482 | 290824 | 72745 | 63124971 |
Constipation | 27.96 | 9.54 | 1281 | 290025 | 223662 | 62974054 |
Pancreatic fibrosis | 27.86 | 9.54 | 12 | 291294 | 86 | 63197630 |
Aphasia | 27.80 | 9.54 | 252 | 291054 | 32748 | 63164968 |
Hepatic function abnormal | 27.72 | 9.54 | 83 | 291223 | 37059 | 63160657 |
Parkinsonism | 27.72 | 9.54 | 108 | 291198 | 10331 | 63187385 |
Restless legs syndrome | 27.47 | 9.54 | 162 | 291144 | 18369 | 63179347 |
Panniculitis | 27.41 | 9.54 | 9 | 291297 | 11376 | 63186340 |
PCO2 increased | 27.27 | 9.54 | 31 | 291275 | 1208 | 63196508 |
Hypophagia | 27.00 | 9.54 | 240 | 291066 | 31019 | 63166697 |
Neonatal seizure | 26.99 | 9.54 | 21 | 291285 | 501 | 63197215 |
Respiratory distress | 26.96 | 9.54 | 256 | 291050 | 33695 | 63164021 |
Macular degeneration | 26.80 | 9.54 | 44 | 291262 | 24332 | 63173384 |
Peripheral venous disease | 26.73 | 9.54 | 141 | 291165 | 15336 | 63182380 |
Tenosynovitis | 26.70 | 9.54 | 15 | 291291 | 13780 | 63183936 |
Bronchiectasis | 26.60 | 9.54 | 21 | 291285 | 16121 | 63181595 |
Accidental exposure to product by child | 26.51 | 9.54 | 30 | 291276 | 1163 | 63196553 |
Obsessive-compulsive disorder | 26.51 | 9.54 | 58 | 291248 | 4002 | 63193714 |
Major depression | 26.42 | 9.54 | 89 | 291217 | 7929 | 63189787 |
Cerebral microhaemorrhage | 26.39 | 9.54 | 13 | 291293 | 131 | 63197585 |
Mean cell haemoglobin increased | 26.38 | 9.54 | 48 | 291258 | 2895 | 63194821 |
Schizophreniform disorder | 26.38 | 9.54 | 11 | 291295 | 72 | 63197644 |
Neonatal asphyxia | 26.25 | 9.54 | 17 | 291289 | 300 | 63197416 |
Brain death | 26.10 | 9.54 | 52 | 291254 | 3358 | 63194358 |
Phagophobia | 26.04 | 9.54 | 10 | 291296 | 51 | 63197665 |
Morbid thoughts | 25.76 | 9.54 | 22 | 291284 | 601 | 63197115 |
Premature delivery | 25.34 | 9.54 | 64 | 291242 | 30217 | 63167499 |
Granulocytopenia | 25.29 | 9.54 | 70 | 291236 | 5602 | 63192114 |
Plasma cell myeloma | 25.25 | 9.54 | 264 | 291042 | 35641 | 63162075 |
Mitochondrial encephalomyopathy | 24.90 | 9.54 | 8 | 291298 | 21 | 63197695 |
Hyperammonaemic encephalopathy | 24.80 | 9.54 | 42 | 291264 | 2392 | 63195324 |
Immunodeficiency | 24.75 | 9.54 | 34 | 291272 | 20220 | 63177496 |
Emotional distress | 24.65 | 9.54 | 243 | 291063 | 32306 | 63165410 |
Antipsychotic drug level increased | 24.65 | 9.54 | 51 | 291255 | 3384 | 63194332 |
Bone erosion | 24.54 | 9.54 | 27 | 291279 | 17690 | 63180026 |
Pneumocystis jirovecii pneumonia | 24.29 | 9.54 | 25 | 291281 | 16889 | 63180827 |
Coma scale | 24.26 | 9.54 | 9 | 291297 | 41 | 63197675 |
Macrocytosis | 24.17 | 9.54 | 42 | 291264 | 2443 | 63195273 |
Femur fracture | 24.06 | 9.54 | 104 | 291202 | 41652 | 63156064 |
Depressed mood | 23.93 | 9.54 | 286 | 291020 | 39905 | 63157811 |
Blood bicarbonate decreased | 23.91 | 9.54 | 46 | 291260 | 2895 | 63194821 |
Hyperhidrosis | 23.85 | 9.54 | 656 | 290650 | 107180 | 63090536 |
Dry mouth | 23.71 | 9.54 | 495 | 290811 | 77368 | 63120348 |
Ill-defined disorder | 23.70 | 9.54 | 250 | 291056 | 81505 | 63116211 |
Acute psychosis | 23.68 | 9.54 | 42 | 291264 | 2483 | 63195233 |
Solar urticaria | 23.54 | 9.54 | 10 | 291296 | 69 | 63197647 |
Homicide | 23.26 | 9.54 | 17 | 291289 | 368 | 63197348 |
Neurosensory hypoacusis | 23.25 | 9.54 | 14 | 291292 | 216 | 63197500 |
Areflexia | 23.21 | 9.54 | 47 | 291259 | 3071 | 63194645 |
Menstrual disorder | 23.13 | 9.54 | 65 | 291241 | 5248 | 63192468 |
Homicidal ideation | 23.07 | 9.54 | 34 | 291272 | 1718 | 63195998 |
Neutropenic sepsis | 22.82 | 9.54 | 25 | 291281 | 16413 | 63181303 |
Urinary incontinence | 22.80 | 9.54 | 236 | 291070 | 31778 | 63165938 |
Malaise | 22.65 | 9.54 | 1623 | 289683 | 414331 | 62783385 |
Upper respiratory tract infection | 22.54 | 9.54 | 254 | 291052 | 81793 | 63115923 |
Bradypnoea | 22.37 | 9.54 | 50 | 291256 | 3500 | 63194216 |
Suicidal behaviour | 22.35 | 9.54 | 42 | 291264 | 2597 | 63195119 |
Hip arthroplasty | 22.11 | 9.54 | 128 | 291178 | 47518 | 63150198 |
Sputum purulent | 21.92 | 9.54 | 26 | 291280 | 1061 | 63196655 |
Blood sodium decreased | 21.88 | 9.54 | 188 | 291118 | 24064 | 63173652 |
Mitochondrial DNA mutation | 21.87 | 9.54 | 17 | 291289 | 405 | 63197311 |
Affective disorder | 21.85 | 9.54 | 70 | 291236 | 6076 | 63191640 |
Muscle disorder | 21.84 | 9.54 | 61 | 291245 | 4908 | 63192808 |
Sacroiliitis | 21.80 | 9.54 | 47 | 291259 | 3210 | 63194506 |
Screaming | 21.75 | 9.54 | 47 | 291259 | 3215 | 63194501 |
Impaired healing | 21.74 | 9.54 | 335 | 290971 | 102207 | 63095509 |
Bone density decreased | 21.67 | 9.54 | 21 | 291285 | 14591 | 63183125 |
Respiratory alkalosis | 21.66 | 9.54 | 42 | 291264 | 2659 | 63195057 |
Toxic epidermal necrolysis | 21.62 | 9.54 | 53 | 291253 | 25281 | 63172435 |
Communication disorder | 21.44 | 9.54 | 40 | 291266 | 2460 | 63195256 |
Respiratory rate decreased | 21.40 | 9.54 | 49 | 291257 | 3486 | 63194230 |
Impaired quality of life | 21.40 | 9.54 | 19 | 291287 | 13764 | 63183952 |
Alcohol use | 21.35 | 9.54 | 36 | 291270 | 2043 | 63195673 |
Ataxia | 21.35 | 9.54 | 131 | 291175 | 15064 | 63182652 |
Skin reaction | 21.27 | 9.54 | 22 | 291284 | 14827 | 63182889 |
Behaviour disorder | 21.23 | 9.54 | 46 | 291260 | 3153 | 63194563 |
Apallic syndrome | 21.12 | 9.54 | 21 | 291285 | 700 | 63197016 |
Autoimmune disorder | 21.02 | 9.54 | 143 | 291163 | 17034 | 63180682 |
Skin maceration | 20.96 | 9.54 | 8 | 291298 | 40 | 63197676 |
Foot deformity | 20.96 | 9.54 | 62 | 291244 | 27791 | 63169925 |
Vomiting | 20.95 | 9.54 | 2901 | 288405 | 556716 | 62641000 |
Altered state of consciousness | 20.92 | 9.54 | 192 | 291114 | 25038 | 63172678 |
Hypochloraemia | 20.92 | 9.54 | 35 | 291271 | 1974 | 63195742 |
Rectal polyp | 20.75 | 9.54 | 27 | 291279 | 1212 | 63196504 |
Waxy flexibility | 20.74 | 9.54 | 11 | 291295 | 131 | 63197585 |
Echolalia | 20.70 | 9.54 | 13 | 291293 | 217 | 63197499 |
Osteoporosis | 20.66 | 9.54 | 166 | 291140 | 57172 | 63140544 |
Coeliac disease | 20.65 | 9.54 | 17 | 291289 | 12780 | 63184936 |
Device difficult to use | 20.64 | 9.54 | 17 | 291289 | 12779 | 63184937 |
Staring | 20.56 | 9.54 | 31 | 291275 | 1599 | 63196117 |
Paralysis | 20.52 | 9.54 | 95 | 291211 | 9805 | 63187911 |
Therapy interrupted | 20.48 | 9.54 | 78 | 291228 | 32377 | 63165339 |
Ulcer | 20.46 | 9.54 | 57 | 291249 | 26050 | 63171666 |
Failure to thrive | 20.37 | 9.54 | 76 | 291230 | 7122 | 63190594 |
Fear | 20.34 | 9.54 | 133 | 291173 | 15633 | 63182083 |
Drop attacks | 20.23 | 9.54 | 20 | 291286 | 662 | 63197054 |
Hypoxic-ischaemic encephalopathy | 20.21 | 9.54 | 54 | 291252 | 4233 | 63193483 |
Bipolar disorder | 20.04 | 9.54 | 81 | 291225 | 7879 | 63189837 |
Mood altered | 20.02 | 9.54 | 126 | 291180 | 14617 | 63183099 |
Accidental death | 20.01 | 9.54 | 34 | 291272 | 1942 | 63195774 |
Haematotoxicity | 19.94 | 9.54 | 9 | 291297 | 9367 | 63188349 |
Haemophagocytic lymphohistiocytosis | 19.94 | 9.54 | 12 | 291294 | 10615 | 63187101 |
Myocardial fibrosis | 19.92 | 9.54 | 21 | 291285 | 751 | 63196965 |
Injection site bruising | 19.77 | 9.54 | 112 | 291194 | 41798 | 63155918 |
Hepatic cytolysis | 19.71 | 9.54 | 25 | 291281 | 15382 | 63182334 |
Protein C increased | 19.62 | 9.54 | 10 | 291296 | 109 | 63197607 |
Rapid eye movements sleep abnormal | 19.51 | 9.54 | 11 | 291295 | 149 | 63197567 |
Fibromyalgia | 19.44 | 9.54 | 495 | 290811 | 79925 | 63117791 |
Ventricular hypokinesia | 19.42 | 9.54 | 56 | 291250 | 4588 | 63193128 |
Alcohol poisoning | 19.41 | 9.54 | 33 | 291273 | 1886 | 63195830 |
Leukocytosis | 19.34 | 9.54 | 193 | 291113 | 25742 | 63171974 |
Device issue | 19.33 | 9.54 | 51 | 291255 | 23730 | 63173986 |
Torsade de pointes | 19.33 | 9.54 | 116 | 291190 | 13235 | 63184481 |
Oxygen saturation abnormal | 19.28 | 9.54 | 47 | 291259 | 3482 | 63194234 |
Hyperprolactinaemia | 19.27 | 9.54 | 50 | 291256 | 3850 | 63193866 |
Disease recurrence | 19.26 | 9.54 | 65 | 291241 | 27965 | 63169751 |
Psychomotor skills impaired | 19.21 | 9.54 | 37 | 291269 | 2331 | 63195385 |
Monocyte count decreased | 19.15 | 9.54 | 35 | 291271 | 2118 | 63195598 |
Withdrawal catatonia | 19.15 | 9.54 | 9 | 291297 | 81 | 63197635 |
Accidental overdose | 19.13 | 9.54 | 177 | 291129 | 23132 | 63174584 |
Vitamin B1 decreased | 19.12 | 9.54 | 12 | 291294 | 200 | 63197516 |
Refusal of treatment by patient | 18.99 | 9.54 | 62 | 291244 | 5435 | 63192281 |
Renal impairment | 18.95 | 9.54 | 288 | 291018 | 88067 | 63109649 |
Urine abnormality | 18.95 | 9.54 | 73 | 291233 | 6946 | 63190770 |
Pallor | 18.85 | 9.54 | 219 | 291087 | 30349 | 63167367 |
Drug use disorder | 18.85 | 9.54 | 58 | 291248 | 4926 | 63192790 |
Drug tolerance decreased | 18.79 | 9.54 | 32 | 291274 | 17441 | 63180275 |
Sleep disorder due to a general medical condition | 18.68 | 9.54 | 17 | 291289 | 12171 | 63185545 |
Decreased appetite | 18.68 | 9.54 | 1365 | 289941 | 249687 | 62948029 |
Oropharyngeal swelling | 18.52 | 9.54 | 22 | 291284 | 899 | 63196817 |
Patent ductus arteriosus | 18.51 | 9.54 | 52 | 291254 | 4198 | 63193518 |
Rhesus antigen positive | 18.51 | 9.54 | 10 | 291296 | 124 | 63197592 |
Inappropriate antidiuretic hormone secretion | 18.49 | 9.54 | 128 | 291178 | 15334 | 63182382 |
Pleocytosis | 18.36 | 9.54 | 21 | 291285 | 824 | 63196892 |
Creatinine renal clearance decreased | 18.34 | 9.54 | 29 | 291277 | 16279 | 63181437 |
Persistent left superior vena cava | 18.34 | 9.54 | 7 | 291299 | 35 | 63197681 |
Frustration tolerance decreased | 18.31 | 9.54 | 72 | 291234 | 6916 | 63190800 |
Polyarthritis | 18.29 | 9.54 | 12 | 291294 | 10134 | 63187582 |
No adverse event | 18.28 | 9.54 | 113 | 291193 | 41292 | 63156424 |
Arthritis | 18.22 | 9.54 | 399 | 290907 | 115522 | 63082194 |
Ear infection | 18.09 | 9.54 | 102 | 291204 | 38111 | 63159605 |
Alcoholism | 18.04 | 9.54 | 31 | 291275 | 1787 | 63195929 |
Device malfunction | 18.03 | 9.54 | 34 | 291272 | 17823 | 63179893 |
Rhabdomyolysis | 17.76 | 9.54 | 292 | 291014 | 43659 | 63154057 |
Inflammation | 17.71 | 9.54 | 268 | 291038 | 82005 | 63115711 |
Logorrhoea | 17.70 | 9.54 | 37 | 291269 | 2473 | 63195243 |
Joint effusion | 17.66 | 9.54 | 32 | 291274 | 17028 | 63180688 |
Dementia | 17.65 | 9.54 | 147 | 291159 | 18647 | 63179069 |
Blood gases abnormal | 17.64 | 9.54 | 20 | 291286 | 777 | 63196939 |
Tremor neonatal | 17.58 | 9.54 | 10 | 291296 | 138 | 63197578 |
Neutrophil count increased | 17.56 | 9.54 | 133 | 291173 | 16394 | 63181322 |
Generalised anxiety disorder | 17.55 | 9.54 | 33 | 291273 | 2041 | 63195675 |
Therapy cessation | 17.46 | 9.54 | 76 | 291230 | 30381 | 63167335 |
Haemoglobin urine | 17.45 | 9.54 | 10 | 291296 | 140 | 63197576 |
Galactorrhoea | 17.28 | 9.54 | 50 | 291256 | 4105 | 63193611 |
Rash pruritic | 17.27 | 9.54 | 183 | 291123 | 59616 | 63138100 |
Laryngeal injury | 17.20 | 9.54 | 5 | 291301 | 8 | 63197708 |
Finger deformity | 17.17 | 9.54 | 7 | 291299 | 7738 | 63189978 |
Injection site rash | 17.14 | 9.54 | 38 | 291268 | 18771 | 63178945 |
Medication error | 17.11 | 9.54 | 336 | 290970 | 51948 | 63145768 |
Wrong drug | 17.09 | 9.54 | 11 | 291295 | 192 | 63197524 |
Hypotonia | 17.02 | 9.54 | 86 | 291220 | 9199 | 63188517 |
Metabolic encephalopathy | 17.00 | 9.54 | 62 | 291244 | 5747 | 63191969 |
Metabolic alkalosis | 16.97 | 9.54 | 41 | 291265 | 3020 | 63194696 |
Blood lactic acid decreased | 16.97 | 9.54 | 10 | 291296 | 148 | 63197568 |
Device use error | 16.91 | 9.54 | 3 | 291303 | 5758 | 63191958 |
Proctalgia | 16.87 | 9.54 | 64 | 291242 | 6046 | 63191670 |
Joint destruction | 16.81 | 9.54 | 4 | 291302 | 6248 | 63191468 |
Hyperchloraemia | 16.64 | 9.54 | 19 | 291287 | 744 | 63196972 |
On and off phenomenon | 16.54 | 9.54 | 30 | 291276 | 1805 | 63195911 |
Hypokalaemia | 16.52 | 9.54 | 607 | 290699 | 103197 | 63094519 |
Cough | 16.44 | 9.54 | 1139 | 290167 | 291604 | 62906112 |
Gallbladder disorder | 16.44 | 9.54 | 145 | 291161 | 18697 | 63179019 |
Tracheal atresia | 16.41 | 9.54 | 6 | 291300 | 26 | 63197690 |
Acute generalised exanthematous pustulosis | 16.40 | 9.54 | 16 | 291290 | 11083 | 63186633 |
Unintentional medical device removal | 16.27 | 9.54 | 4 | 291302 | 6111 | 63191605 |
pH urine increased | 16.22 | 9.54 | 14 | 291292 | 388 | 63197328 |
Prescribed overdose | 16.14 | 9.54 | 233 | 291073 | 33920 | 63163796 |
Anxiety disorder | 16.14 | 9.54 | 48 | 291258 | 4002 | 63193714 |
Nervousness | 16.12 | 9.54 | 215 | 291091 | 30764 | 63166952 |
Dysphemia | 16.10 | 9.54 | 37 | 291269 | 2638 | 63195078 |
Irritability | 16.10 | 9.54 | 219 | 291087 | 31475 | 63166241 |
Pleurothotonus | 16.09 | 9.54 | 25 | 291281 | 1324 | 63196392 |
Muscle spasticity | 16.05 | 9.54 | 49 | 291257 | 21745 | 63175971 |
Therapeutic product ineffective | 16.01 | 9.54 | 29 | 291277 | 1743 | 63195973 |
Tendonitis | 15.99 | 9.54 | 42 | 291264 | 19573 | 63178143 |
Neonatal behavioural syndrome | 15.93 | 9.54 | 7 | 291299 | 53 | 63197663 |
Sleep disorder due to general medical condition, insomnia type | 15.82 | 9.54 | 158 | 291148 | 52059 | 63145657 |
Atonic seizures | 15.81 | 9.54 | 17 | 291289 | 622 | 63197094 |
Postural tremor | 15.76 | 9.54 | 13 | 291293 | 338 | 63197378 |
Dopamine transporter scintigraphy abnormal | 15.71 | 9.54 | 8 | 291298 | 87 | 63197629 |
Cardiac malposition | 15.71 | 9.54 | 7 | 291299 | 55 | 63197661 |
Breast cancer stage I | 15.64 | 9.54 | 6 | 291300 | 6883 | 63190833 |
Neonatal respiratory failure | 15.61 | 9.54 | 12 | 291294 | 281 | 63197435 |
Bronchitis | 15.58 | 9.54 | 445 | 290861 | 124490 | 63073226 |
Hypervigilance | 15.54 | 9.54 | 13 | 291293 | 345 | 63197371 |
Cannabinoid hyperemesis syndrome | 15.49 | 9.54 | 7 | 291299 | 57 | 63197659 |
Angioedema | 15.44 | 9.54 | 143 | 291163 | 47822 | 63149894 |
Anger | 15.42 | 9.54 | 104 | 291202 | 12352 | 63185364 |
Anomalous pulmonary venous connection | 15.39 | 9.54 | 7 | 291299 | 58 | 63197658 |
Platelet production decreased | 15.33 | 9.54 | 4 | 291302 | 3 | 63197713 |
Thymus disorder | 15.33 | 9.54 | 12 | 291294 | 289 | 63197427 |
Self-medication | 15.31 | 9.54 | 37 | 291269 | 2726 | 63194990 |
Cholangitis infective | 15.29 | 9.54 | 13 | 291293 | 353 | 63197363 |
Gastrointestinal sounds abnormal | 15.19 | 9.54 | 47 | 291259 | 4004 | 63193712 |
Apathy | 15.11 | 9.54 | 80 | 291226 | 8714 | 63189002 |
Suspected suicide attempt | 15.05 | 9.54 | 9 | 291297 | 137 | 63197579 |
Death | 15.00 | 9.54 | 1949 | 289357 | 372432 | 62825284 |
Respiratory tract infection | 14.99 | 9.54 | 120 | 291186 | 41363 | 63156353 |
Morose | 14.96 | 9.54 | 6 | 291300 | 35 | 63197681 |
Squamous cell carcinoma of the oral cavity | 14.95 | 9.54 | 12 | 291294 | 300 | 63197416 |
Psychotic behaviour | 14.91 | 9.54 | 16 | 291290 | 584 | 63197132 |
Autonomic nervous system imbalance | 14.83 | 9.54 | 37 | 291269 | 2781 | 63194935 |
Obesity | 14.82 | 9.54 | 206 | 291100 | 29746 | 63167970 |
Tooth hypoplasia | 14.80 | 9.54 | 7 | 291299 | 64 | 63197652 |
Fluid retention | 14.78 | 9.54 | 189 | 291117 | 59497 | 63138219 |
Central nervous system necrosis | 14.77 | 9.54 | 9 | 291297 | 142 | 63197574 |
Loss of libido | 14.72 | 9.54 | 24 | 291282 | 1325 | 63196391 |
Gait disturbance | 14.66 | 9.54 | 1002 | 290304 | 182176 | 63015540 |
Amnesia | 14.59 | 9.54 | 346 | 290960 | 55239 | 63142477 |
Impaired work ability | 14.57 | 9.54 | 37 | 291269 | 17438 | 63180278 |
Diaphragmatic rupture | 14.55 | 9.54 | 11 | 291295 | 251 | 63197465 |
Transient aphasia | 14.55 | 9.54 | 6 | 291300 | 38 | 63197678 |
Lymphocyte count decreased | 14.53 | 9.54 | 207 | 291099 | 30050 | 63167666 |
Enthesopathy | 14.46 | 9.54 | 11 | 291295 | 8603 | 63189113 |
Uveitis | 14.43 | 9.54 | 22 | 291284 | 12531 | 63185185 |
Injury | 14.38 | 9.54 | 439 | 290867 | 72808 | 63124908 |
Pulmonary embolism | 14.37 | 9.54 | 664 | 290642 | 116020 | 63081696 |
Duodenal ulcer perforation | 14.33 | 9.54 | 298 | 291008 | 86911 | 63110805 |
Drug clearance decreased | 14.33 | 9.54 | 25 | 291281 | 1459 | 63196257 |
Oppositional defiant disorder | 14.30 | 9.54 | 6 | 291300 | 40 | 63197676 |
Glaucoma | 14.28 | 9.54 | 42 | 291264 | 18863 | 63178853 |
Secondary immunodeficiency | 14.27 | 9.54 | 24 | 291282 | 1359 | 63196357 |
Bulimia nervosa | 14.24 | 9.54 | 14 | 291292 | 460 | 63197256 |
Head injury | 14.20 | 9.54 | 190 | 291116 | 27206 | 63170510 |
Arrhythmia | 14.18 | 9.54 | 250 | 291056 | 37890 | 63159826 |
Ductus arteriosus premature closure | 14.17 | 9.54 | 12 | 291294 | 324 | 63197392 |
Febrile bone marrow aplasia | 14.13 | 9.54 | 8 | 291298 | 7317 | 63190399 |
Intentional product use issue | 14.12 | 9.54 | 463 | 290843 | 127429 | 63070287 |
Skin exfoliation | 14.09 | 9.54 | 128 | 291178 | 42974 | 63154742 |
Inappropriate schedule of product administration | 14.08 | 9.54 | 366 | 290940 | 103599 | 63094117 |
Visceral congestion | 14.04 | 9.54 | 12 | 291294 | 328 | 63197388 |
Cardiac failure | 13.95 | 9.54 | 307 | 290999 | 88835 | 63108881 |
Extensor plantar response | 13.86 | 9.54 | 23 | 291283 | 1288 | 63196428 |
Thinking abnormal | 13.86 | 9.54 | 90 | 291216 | 10553 | 63187163 |
Electrocardiogram T wave abnormal | 13.81 | 9.54 | 33 | 291273 | 2414 | 63195302 |
Foot operation | 13.80 | 9.54 | 8 | 291298 | 7223 | 63190493 |
Suspected suicide | 13.60 | 9.54 | 63 | 291243 | 6505 | 63191211 |
Pulmonary toxicity | 13.55 | 9.54 | 14 | 291292 | 9441 | 63188275 |
Echopraxia | 13.44 | 9.54 | 5 | 291301 | 23 | 63197693 |
Mucosal dryness | 13.38 | 9.54 | 35 | 291271 | 2709 | 63195007 |
Rheumatic fever | 13.25 | 9.54 | 130 | 291176 | 42981 | 63154735 |
Sleep disorder | 13.23 | 9.54 | 478 | 290828 | 81088 | 63116628 |
Pruritus allergic | 13.18 | 9.54 | 25 | 291281 | 1557 | 63196159 |
Antidepressant drug level below therapeutic | 13.17 | 9.54 | 3 | 291303 | 0 | 63197716 |
Maximal voluntary ventilation abnormal | 13.10 | 9.54 | 5 | 291301 | 25 | 63197691 |
Pupillary reflex impaired | 13.09 | 9.54 | 29 | 291277 | 2018 | 63195698 |
Abdominal pain | 13.08 | 9.54 | 1538 | 289768 | 291918 | 62905798 |
Device dislocation | 13.06 | 9.54 | 67 | 291239 | 25638 | 63172078 |
Blood albumin increased | 13.04 | 9.54 | 19 | 291287 | 950 | 63196766 |
Drug abuser | 12.96 | 9.54 | 36 | 291270 | 2887 | 63194829 |
Hypernatraemia | 12.92 | 9.54 | 69 | 291237 | 7540 | 63190176 |
Surgery | 12.92 | 9.54 | 104 | 291202 | 35808 | 63161908 |
Congenital pneumonia | 12.88 | 9.54 | 4 | 291302 | 9 | 63197707 |
Drug screen false positive | 12.88 | 9.54 | 18 | 291288 | 866 | 63196850 |
Benzodiazepine drug level increased | 12.80 | 9.54 | 9 | 291297 | 183 | 63197533 |
Induced abortion failed | 12.73 | 9.54 | 10 | 291296 | 242 | 63197474 |
Anaphylactic reaction | 12.67 | 9.54 | 220 | 291086 | 65880 | 63131836 |
Neutrophil Pelger-Huet anomaly present | 12.67 | 9.54 | 7 | 291299 | 91 | 63197625 |
Vasculitis | 12.67 | 9.54 | 42 | 291264 | 18167 | 63179549 |
Influenza | 12.62 | 9.54 | 391 | 290915 | 108331 | 63089385 |
Labelled drug-drug interaction issue | 12.57 | 9.54 | 20 | 291286 | 1081 | 63196635 |
Joint stiffness | 12.55 | 9.54 | 127 | 291179 | 41742 | 63155974 |
Cerebellar haematoma | 12.50 | 9.54 | 12 | 291294 | 383 | 63197333 |
Delusion of grandeur | 12.49 | 9.54 | 10 | 291296 | 249 | 63197467 |
Product complaint | 12.46 | 9.54 | 101 | 291205 | 12708 | 63185008 |
Acute respiratory failure | 12.45 | 9.54 | 225 | 291081 | 34260 | 63163456 |
Inflammatory marker increased | 12.45 | 9.54 | 8 | 291298 | 6831 | 63190885 |
Inappropriate affect | 12.42 | 9.54 | 18 | 291288 | 896 | 63196820 |
Normal newborn | 12.36 | 9.54 | 12 | 291294 | 8329 | 63189387 |
Live birth | 12.35 | 9.54 | 68 | 291238 | 25562 | 63172154 |
Leukopenia neonatal | 12.35 | 9.54 | 5 | 291301 | 30 | 63197686 |
Vulvar basal cell carcinoma | 12.35 | 9.54 | 5 | 291301 | 30 | 63197686 |
Melaena | 12.33 | 9.54 | 85 | 291221 | 30280 | 63167436 |
Hyperthyroidism | 12.29 | 9.54 | 31 | 291275 | 14642 | 63183074 |
Parachute mitral valve | 12.28 | 9.54 | 7 | 291299 | 97 | 63197619 |
Urine ketone body present | 12.28 | 9.54 | 32 | 291274 | 2471 | 63195245 |
Diverticulitis | 12.27 | 9.54 | 119 | 291187 | 39438 | 63158278 |
Rabbit syndrome | 12.27 | 9.54 | 11 | 291295 | 321 | 63197395 |
Impaired driving ability | 12.25 | 9.54 | 47 | 291259 | 4464 | 63193252 |
Arterial spasm | 12.22 | 9.54 | 6 | 291300 | 60 | 63197656 |
Musculoskeletal disorder | 12.15 | 9.54 | 51 | 291255 | 20593 | 63177123 |
Erysipelas | 12.15 | 9.54 | 11 | 291295 | 7894 | 63189822 |
Incoherent | 12.13 | 9.54 | 47 | 291259 | 4483 | 63193233 |
Autologous bone marrow transplantation therapy | 12.07 | 9.54 | 4 | 291302 | 12 | 63197704 |
Depressive delusion | 12.07 | 9.54 | 4 | 291302 | 12 | 63197704 |
Soft tissue swelling | 12.07 | 9.54 | 21 | 291285 | 1223 | 63196493 |
Osteonecrosis of jaw | 12.05 | 9.54 | 103 | 291203 | 35020 | 63162696 |
Sluggishness | 12.00 | 9.54 | 52 | 291254 | 5217 | 63192499 |
Adverse event | 11.96 | 9.54 | 228 | 291078 | 67331 | 63130385 |
Tachyphylaxis | 11.93 | 9.54 | 10 | 291296 | 266 | 63197450 |
Cognitive disorder | 11.90 | 9.54 | 338 | 290968 | 55477 | 63142239 |
Therapy non-responder | 11.87 | 9.54 | 443 | 290863 | 75458 | 63122258 |
Pleural adhesion | 11.85 | 9.54 | 7 | 291299 | 104 | 63197612 |
Cardiac failure congestive | 11.84 | 9.54 | 328 | 290978 | 92105 | 63105611 |
Hypoprolactinaemia | 11.83 | 9.54 | 4 | 291302 | 13 | 63197703 |
Tachyphrenia | 11.80 | 9.54 | 22 | 291284 | 1352 | 63196364 |
Hepatitis | 11.80 | 9.54 | 121 | 291185 | 39667 | 63158049 |
Rhinalgia | 11.78 | 9.54 | 24 | 291282 | 1575 | 63196141 |
Nephrogenic diabetes insipidus | 11.76 | 9.54 | 18 | 291288 | 941 | 63196775 |
Water intoxication | 11.71 | 9.54 | 12 | 291294 | 415 | 63197301 |
Acute respiratory distress syndrome | 11.70 | 9.54 | 162 | 291144 | 23372 | 63174344 |
Cyanosis | 11.66 | 9.54 | 124 | 291182 | 16811 | 63180905 |
Device breakage | 11.63 | 9.54 | 22 | 291284 | 11520 | 63186196 |
Vasoconstriction | 11.60 | 9.54 | 14 | 291292 | 582 | 63197134 |
Scleritis | 11.58 | 9.54 | 3 | 291303 | 4425 | 63193291 |
Differential white blood cell count abnormal | 11.45 | 9.54 | 16 | 291290 | 770 | 63196946 |
Neoplasm malignant | 11.44 | 9.54 | 85 | 291221 | 29776 | 63167940 |
Kluver-Bucy syndrome | 11.39 | 9.54 | 4 | 291302 | 15 | 63197701 |
Hypersexuality | 11.39 | 9.54 | 13 | 291293 | 509 | 63197207 |
Stereotypy | 11.36 | 9.54 | 12 | 291294 | 430 | 63197286 |
Partial seizures | 11.34 | 9.54 | 55 | 291251 | 5787 | 63191929 |
Left ventricle outflow tract obstruction | 11.32 | 9.54 | 10 | 291296 | 286 | 63197430 |
Drug screen negative | 11.32 | 9.54 | 10 | 291296 | 286 | 63197430 |
Injection site warmth | 11.31 | 9.54 | 34 | 291272 | 15161 | 63182555 |
Biliary tract infection | 11.30 | 9.54 | 15 | 291291 | 687 | 63197029 |
Anion gap increased | 11.29 | 9.54 | 26 | 291280 | 1856 | 63195860 |
Brain oedema | 11.25 | 9.54 | 107 | 291199 | 14088 | 63183628 |
Polydipsia | 11.25 | 9.54 | 39 | 291267 | 3525 | 63194191 |
Amegakaryocytic thrombocytopenia | 11.19 | 9.54 | 4 | 291302 | 16 | 63197700 |
Natural killer cell count | 11.19 | 9.54 | 4 | 291302 | 16 | 63197700 |
Maternal exposure before pregnancy | 11.19 | 9.54 | 11 | 291295 | 7592 | 63190124 |
Blood lactic acid increased | 11.19 | 9.54 | 63 | 291243 | 7023 | 63190693 |
Hypercapnia | 11.17 | 9.54 | 52 | 291254 | 5379 | 63192337 |
Antidepressant drug level decreased | 11.10 | 9.54 | 3 | 291303 | 3 | 63197713 |
Patient restraint | 11.10 | 9.54 | 3 | 291303 | 3 | 63197713 |
Benzodiazepine drug level | 11.10 | 9.54 | 3 | 291303 | 3 | 63197713 |
Anti-neuronal antibody positive | 11.10 | 9.54 | 3 | 291303 | 3 | 63197713 |
Increased appetite | 11.09 | 9.54 | 79 | 291227 | 9551 | 63188165 |
Blood creatine increased | 11.06 | 9.54 | 53 | 291253 | 5548 | 63192168 |
Non-small cell lung cancer | 11.06 | 9.54 | 39 | 291267 | 3556 | 63194160 |
Incision site complication | 11.05 | 9.54 | 14 | 291292 | 612 | 63197104 |
Osteoradionecrosis | 11.04 | 9.54 | 7 | 291299 | 119 | 63197597 |
Toxicologic test abnormal | 10.98 | 9.54 | 15 | 291291 | 706 | 63197010 |
Fear of injection | 10.97 | 9.54 | 10 | 291296 | 7154 | 63190562 |
Drug resistance | 10.97 | 9.54 | 61 | 291245 | 22872 | 63174844 |
Pathogen resistance | 10.96 | 9.54 | 8 | 291298 | 6390 | 63191326 |
Hallucination, tactile | 10.95 | 9.54 | 10 | 291296 | 299 | 63197417 |
Pressure of speech | 10.90 | 9.54 | 15 | 291291 | 711 | 63197005 |
Vision blurred | 10.87 | 9.54 | 521 | 290785 | 91403 | 63106313 |
Carbohydrate antigen 125 increased | 10.87 | 9.54 | 33 | 291273 | 2783 | 63194933 |
Dysmetropsia | 10.86 | 9.54 | 6 | 291300 | 78 | 63197638 |
Stillbirth | 10.85 | 9.54 | 9 | 291297 | 6741 | 63190975 |
Device adhesion issue | 10.83 | 9.54 | 5 | 291301 | 5136 | 63192580 |
Hyponatriuria | 10.82 | 9.54 | 4 | 291302 | 18 | 63197698 |
Red cell distribution width increased | 10.80 | 9.54 | 84 | 291222 | 10440 | 63187276 |
Cerebral atrophy | 10.79 | 9.54 | 49 | 291257 | 5017 | 63192699 |
Systolic hypertension | 10.78 | 9.54 | 12 | 291294 | 457 | 63197259 |
Antidepressant drug level increased | 10.76 | 9.54 | 10 | 291296 | 306 | 63197410 |
Tuberculosis | 10.76 | 9.54 | 22 | 291284 | 11189 | 63186527 |
Clonus | 10.75 | 9.54 | 46 | 291260 | 4590 | 63193126 |
Hyponatraemic syndrome | 10.74 | 9.54 | 13 | 291293 | 542 | 63197174 |
Sneezing | 10.73 | 9.54 | 45 | 291261 | 18173 | 63179543 |
Regressive behaviour | 10.72 | 9.54 | 8 | 291298 | 179 | 63197537 |
Hypoaesthesia oral | 10.71 | 9.54 | 99 | 291207 | 12934 | 63184782 |
Troponin T increased | 10.67 | 9.54 | 20 | 291286 | 1234 | 63196482 |
Delusional perception | 10.66 | 9.54 | 9 | 291297 | 242 | 63197474 |
Cardiovascular disorder | 10.65 | 9.54 | 24 | 291282 | 11788 | 63185928 |
Dependence | 10.65 | 9.54 | 27 | 291279 | 2050 | 63195666 |
Affective ambivalence | 10.65 | 9.54 | 4 | 291302 | 19 | 63197697 |
Delusional disorder, unspecified type | 10.60 | 9.54 | 11 | 291295 | 386 | 63197330 |
False positive investigation result | 10.58 | 9.54 | 14 | 291292 | 639 | 63197077 |
Tri-iodothyronine free decreased | 10.55 | 9.54 | 10 | 291296 | 314 | 63197402 |
Drug diversion | 10.52 | 9.54 | 17 | 291289 | 931 | 63196785 |
Eczema | 10.51 | 9.54 | 96 | 291210 | 32195 | 63165521 |
Transplant rejection | 10.47 | 9.54 | 21 | 291285 | 10759 | 63186957 |
Hepatocellular injury | 10.46 | 9.54 | 78 | 291228 | 27303 | 63170413 |
Bone marrow failure | 10.46 | 9.54 | 85 | 291221 | 29205 | 63168511 |
Gastric ulcer | 10.41 | 9.54 | 66 | 291240 | 23971 | 63173745 |
Basophil count increased | 10.40 | 9.54 | 17 | 291289 | 940 | 63196776 |
Tongue movement disturbance | 10.37 | 9.54 | 10 | 291296 | 321 | 63197395 |
Limbic encephalitis | 10.37 | 9.54 | 10 | 291296 | 321 | 63197395 |
Schizoaffective disorder bipolar type | 10.27 | 9.54 | 7 | 291299 | 135 | 63197581 |
Abortion spontaneous complete | 10.25 | 9.54 | 3 | 291303 | 5 | 63197711 |
Malignant catatonia | 10.24 | 9.54 | 8 | 291298 | 192 | 63197524 |
Hypoglycaemia | 10.24 | 9.54 | 204 | 291102 | 59861 | 63137855 |
C-reactive protein | 10.23 | 9.54 | 47 | 291259 | 4835 | 63192881 |
Lupus-like syndrome | 10.15 | 9.54 | 36 | 291270 | 15259 | 63182457 |
Intestinal strangulation | 10.11 | 9.54 | 6 | 291300 | 90 | 63197626 |
Balance disorder | 10.09 | 9.54 | 479 | 290827 | 83943 | 63113773 |
Adrenal insufficiency | 10.09 | 9.54 | 45 | 291261 | 17870 | 63179846 |
Malnutrition | 10.07 | 9.54 | 111 | 291195 | 15187 | 63182529 |
Product storage error | 10.06 | 9.54 | 35 | 291271 | 14921 | 63182795 |
Drug withdrawal convulsions | 10.04 | 9.54 | 21 | 291285 | 1404 | 63196312 |
Disinhibition | 10.03 | 9.54 | 16 | 291290 | 867 | 63196849 |
Macrophages increased | 10.02 | 9.54 | 4 | 291302 | 23 | 63197693 |
Antidepressant discontinuation syndrome | 10.02 | 9.54 | 5 | 291301 | 52 | 63197664 |
Pneumonia | 10.01 | 9.54 | 1895 | 289411 | 454872 | 62742844 |
Blood immunoglobulin M decreased | 10.00 | 9.54 | 17 | 291289 | 971 | 63196745 |
Wound infection fungal | 9.97 | 9.54 | 7 | 291299 | 142 | 63197574 |
Hypertransaminasaemia | 9.94 | 9.54 | 58 | 291248 | 6551 | 63191165 |
Asthma | 9.92 | 9.54 | 481 | 290825 | 127080 | 63070636 |
Injection site haemorrhage | 9.90 | 9.54 | 68 | 291238 | 24246 | 63173470 |
Intestinal perforation | 9.90 | 9.54 | 91 | 291215 | 11872 | 63185844 |
Morbihan disease | 9.88 | 9.54 | 4 | 291302 | 24 | 63197692 |
Discoloured vomit | 9.88 | 9.54 | 16 | 291290 | 878 | 63196838 |
Post-traumatic stress disorder | 9.88 | 9.54 | 49 | 291257 | 5202 | 63192514 |
Klebsiella bacteraemia | 9.87 | 9.54 | 23 | 291283 | 1655 | 63196061 |
Skin cancer | 9.85 | 9.54 | 24 | 291282 | 11471 | 63186245 |
Parkinsonian gait | 9.79 | 9.54 | 12 | 291294 | 507 | 63197209 |
Cardiac failure chronic | 9.78 | 9.54 | 4 | 291302 | 4414 | 63193302 |
White blood cell count decreased | 9.77 | 9.54 | 753 | 290553 | 138351 | 63059365 |
Muscle tension dysphonia | 9.76 | 9.54 | 8 | 291298 | 206 | 63197510 |
Cytomegalovirus viraemia | 9.76 | 9.54 | 7 | 291299 | 5642 | 63192074 |
Gastric disorder | 9.75 | 9.54 | 117 | 291189 | 37252 | 63160464 |
Platelet morphology abnormal | 9.75 | 9.54 | 4 | 291302 | 25 | 63197691 |
Blood magnesium decreased | 9.74 | 9.54 | 98 | 291208 | 13100 | 63184616 |
Compulsions | 9.73 | 9.54 | 8 | 291298 | 207 | 63197509 |
Antidepressant drug level above therapeutic | 9.73 | 9.54 | 11 | 291295 | 426 | 63197290 |
Brain herniation | 9.73 | 9.54 | 38 | 291268 | 3639 | 63194077 |
Verbal abuse | 9.72 | 9.54 | 6 | 291300 | 97 | 63197619 |
Sarcoidosis | 9.70 | 9.54 | 11 | 291295 | 7111 | 63190605 |
Gallbladder cholesterolosis | 9.70 | 9.54 | 15 | 291291 | 791 | 63196925 |
Cellulitis | 9.70 | 9.54 | 294 | 291012 | 81664 | 63116052 |
Ventricular arrhythmia | 9.68 | 9.54 | 39 | 291267 | 3789 | 63193927 |
Culture urine positive | 9.67 | 9.54 | 38 | 291268 | 3649 | 63194067 |
Gout | 9.66 | 9.54 | 30 | 291276 | 13241 | 63184475 |
Rhinorrhoea | 9.65 | 9.54 | 228 | 291078 | 65349 | 63132367 |
Impulsive behaviour | 9.64 | 9.54 | 22 | 291284 | 1561 | 63196155 |
Drug dose omission by device | 9.61 | 9.54 | 5 | 291301 | 4796 | 63192920 |
Aplastic anaemia | 9.61 | 9.54 | 76 | 291230 | 9493 | 63188223 |
Road traffic accident | 9.61 | 9.54 | 228 | 291078 | 36404 | 63161312 |
Dysaesthesia pharynx | 9.60 | 9.54 | 7 | 291299 | 151 | 63197565 |
Drug withdrawal syndrome neonatal | 9.59 | 9.54 | 26 | 291280 | 2055 | 63195661 |
Sensory loss | 9.57 | 9.54 | 80 | 291226 | 10158 | 63187558 |
Synovial cyst | 9.57 | 9.54 | 21 | 291285 | 10412 | 63187304 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Sopor | 859.15 | 10.31 | 579 | 152129 | 11557 | 34792666 |
Agitation | 434.71 | 10.31 | 846 | 151862 | 56553 | 34747670 |
Neuroleptic malignant syndrome | 433.08 | 10.31 | 460 | 152248 | 17474 | 34786749 |
Drug abuse | 425.97 | 10.31 | 1168 | 151540 | 97928 | 34706295 |
Catatonia | 334.77 | 10.31 | 231 | 152477 | 4794 | 34799429 |
Intentional self-injury | 317.99 | 10.31 | 345 | 152363 | 13426 | 34790797 |
Bradyphrenia | 301.96 | 10.31 | 213 | 152495 | 4585 | 34799638 |
Sedation | 275.10 | 10.31 | 396 | 152312 | 20610 | 34783613 |
Psychotic disorder | 273.22 | 10.31 | 428 | 152280 | 24024 | 34780199 |
Aggression | 263.42 | 10.31 | 548 | 152160 | 38416 | 34765807 |
Completed suicide | 253.99 | 10.31 | 973 | 151735 | 97195 | 34707028 |
Suicide attempt | 249.21 | 10.31 | 537 | 152171 | 38579 | 34765644 |
Delirium | 231.56 | 10.31 | 560 | 152148 | 43431 | 34760792 |
Somnolence | 223.77 | 10.31 | 1020 | 151688 | 110096 | 34694127 |
Extrapyramidal disorder | 180.73 | 10.31 | 251 | 152457 | 12629 | 34791594 |
Anxiety | 170.71 | 10.31 | 872 | 151836 | 98556 | 34705667 |
Schizophrenia | 169.18 | 10.31 | 199 | 152509 | 8467 | 34795756 |
Confusional state | 157.13 | 10.31 | 1123 | 151585 | 143037 | 34661186 |
Hallucination, auditory | 153.57 | 10.31 | 223 | 152485 | 11694 | 34792529 |
Dysarthria | 137.39 | 10.31 | 398 | 152310 | 34384 | 34769839 |
Intentional overdose | 136.74 | 10.31 | 461 | 152247 | 43213 | 34761010 |
Drug dependence | 134.63 | 10.31 | 315 | 152393 | 23902 | 34780321 |
Drug withdrawal syndrome | 134.03 | 10.31 | 279 | 152429 | 19555 | 34784668 |
Overdose | 132.20 | 10.31 | 763 | 151945 | 90296 | 34713927 |
Interstitial lung disease | 117.01 | 10.31 | 70 | 152638 | 65212 | 34739011 |
Restlessness | 115.88 | 10.31 | 307 | 152401 | 25175 | 34779048 |
Muscle rigidity | 109.07 | 10.31 | 178 | 152530 | 10340 | 34793883 |
Mental status changes | 102.89 | 10.31 | 383 | 152325 | 37700 | 34766523 |
Suicidal ideation | 99.94 | 10.31 | 395 | 152313 | 39993 | 34764230 |
Respiratory depression | 95.46 | 10.31 | 216 | 152492 | 16029 | 34788194 |
Disorientation | 94.90 | 10.31 | 340 | 152368 | 32848 | 34771375 |
Febrile neutropenia | 92 | 10.31 | 958 | 151750 | 135891 | 34668332 |
Abnormal behaviour | 91.26 | 10.31 | 278 | 152430 | 24691 | 34779532 |
Tachycardia | 90.26 | 10.31 | 657 | 152051 | 84115 | 34720108 |
Depressed level of consciousness | 89.60 | 10.31 | 398 | 152310 | 42443 | 34761780 |
Parkinsonism | 86.12 | 10.31 | 139 | 152569 | 7999 | 34796224 |
Delusion | 83.33 | 10.31 | 176 | 152532 | 12459 | 34791764 |
Seizure | 81.64 | 10.31 | 757 | 151951 | 104100 | 34700123 |
Toxicity to various agents | 80.41 | 10.31 | 1275 | 151433 | 199087 | 34605136 |
Ataxia | 77.87 | 10.31 | 181 | 152527 | 13672 | 34790551 |
COVID-19 | 72.56 | 10.31 | 143 | 152565 | 77407 | 34726816 |
Akathisia | 70.61 | 10.31 | 127 | 152581 | 7982 | 34796241 |
Joint swelling | 69.47 | 10.31 | 96 | 152612 | 59794 | 34744429 |
Psychomotor hyperactivity | 65.75 | 10.31 | 136 | 152572 | 9486 | 34794737 |
Bradykinesia | 65.60 | 10.31 | 83 | 152625 | 3810 | 34800413 |
Withdrawal syndrome | 63.82 | 10.31 | 157 | 152551 | 12298 | 34791925 |
Serotonin syndrome | 62.88 | 10.31 | 211 | 152497 | 19722 | 34784501 |
Mental impairment | 62.60 | 10.31 | 139 | 152569 | 10183 | 34794040 |
Sedation complication | 62.43 | 10.31 | 56 | 152652 | 1721 | 34802502 |
Salivary hypersecretion | 62.42 | 10.31 | 125 | 152583 | 8519 | 34795704 |
Unresponsive to stimuli | 62.14 | 10.31 | 262 | 152446 | 27307 | 34776916 |
Rheumatoid arthritis | 61.77 | 10.31 | 46 | 152662 | 38192 | 34766031 |
Hallucination | 61.77 | 10.31 | 411 | 152297 | 51087 | 34753136 |
Product dose omission issue | 61.56 | 10.31 | 291 | 152417 | 119420 | 34684803 |
Acute kidney injury | 60.82 | 10.31 | 952 | 151756 | 304036 | 34500187 |
Pruritus | 60.34 | 10.31 | 368 | 152340 | 141613 | 34662610 |
Speech disorder | 60.16 | 10.31 | 247 | 152461 | 25439 | 34778784 |
Myelosuppression | 59.77 | 10.31 | 7 | 152701 | 19258 | 34784965 |
Blood creatine phosphokinase increased | 58.08 | 10.31 | 365 | 152343 | 44492 | 34759731 |
Dystonia | 58.02 | 10.31 | 139 | 152569 | 10706 | 34793517 |
Granulocytopenia | 57.37 | 10.31 | 103 | 152605 | 6464 | 34797759 |
Paradoxical drug reaction | 57.35 | 10.31 | 72 | 152636 | 3279 | 34800944 |
Paranoia | 54.45 | 10.31 | 145 | 152563 | 11923 | 34792300 |
Miosis | 54.04 | 10.31 | 125 | 152583 | 9410 | 34794813 |
Anaemia | 52.88 | 10.31 | 710 | 151998 | 232625 | 34571598 |
Dyskinesia | 52.86 | 10.31 | 216 | 152492 | 22197 | 34782026 |
Drug interaction | 52.57 | 10.31 | 1325 | 151383 | 224621 | 34579602 |
Arthralgia | 52.57 | 10.31 | 482 | 152226 | 169559 | 34634664 |
Psoriasis | 51.56 | 10.31 | 56 | 152652 | 38756 | 34765467 |
Needle fatigue | 50.59 | 10.31 | 37 | 152671 | 844 | 34803379 |
Renal impairment | 50.20 | 10.31 | 227 | 152481 | 94286 | 34709937 |
Peripheral swelling | 50.14 | 10.31 | 169 | 152539 | 76372 | 34727851 |
Refusal of treatment by patient | 49.27 | 10.31 | 83 | 152625 | 4949 | 34799274 |
Antipsychotic drug level decreased | 48.01 | 10.31 | 38 | 152670 | 979 | 34803244 |
Delusion of grandeur | 47.71 | 10.31 | 40 | 152668 | 1120 | 34803103 |
Gait spastic | 47.59 | 10.31 | 39 | 152669 | 1057 | 34803166 |
Multiple organ dysfunction syndrome | 47.51 | 10.31 | 173 | 152535 | 76393 | 34727830 |
Negativism | 47.50 | 10.31 | 27 | 152681 | 392 | 34803831 |
Treatment noncompliance | 47.12 | 10.31 | 245 | 152463 | 27855 | 34776368 |
Cytomegalovirus infection | 46.84 | 10.31 | 28 | 152680 | 26107 | 34778116 |
Hypokinesia | 46.63 | 10.31 | 113 | 152595 | 8767 | 34795456 |
Prostate cancer | 46.53 | 10.31 | 63 | 152645 | 39586 | 34764637 |
Poverty of speech | 46.37 | 10.31 | 22 | 152686 | 214 | 34804009 |
Movement disorder | 46.28 | 10.31 | 138 | 152570 | 12110 | 34792113 |
Major depression | 45.55 | 10.31 | 76 | 152632 | 4496 | 34799727 |
Relapsing-remitting multiple sclerosis | 44.84 | 10.31 | 37 | 152671 | 1013 | 34803210 |
Stupor | 44.59 | 10.31 | 59 | 152649 | 2832 | 34801391 |
Electrocardiogram QT prolonged | 44.47 | 10.31 | 319 | 152389 | 40633 | 34763590 |
Psoriatic arthropathy | 43.51 | 10.31 | 16 | 152692 | 19782 | 34784441 |
Multiple drug therapy | 42.53 | 10.31 | 26 | 152682 | 435 | 34803788 |
Antipsychotic drug level increased | 42.24 | 10.31 | 67 | 152641 | 3798 | 34800425 |
Treatment failure | 42.05 | 10.31 | 88 | 152620 | 46609 | 34757614 |
Sinus tachycardia | 41.49 | 10.31 | 168 | 152540 | 17192 | 34787031 |
Coma | 41.34 | 10.31 | 341 | 152367 | 45337 | 34758886 |
Irritability | 41.21 | 10.31 | 215 | 152493 | 24475 | 34779748 |
Withdrawal catatonia | 40.85 | 10.31 | 16 | 152692 | 92 | 34804131 |
Rash | 40.47 | 10.31 | 707 | 152001 | 222045 | 34582178 |
Hepatic function abnormal | 40.46 | 10.31 | 83 | 152625 | 44280 | 34759943 |
Drug ineffective | 40.13 | 10.31 | 1611 | 151097 | 455140 | 34349083 |
Homicide | 39.61 | 10.31 | 33 | 152675 | 916 | 34803307 |
Bladder cancer | 39.59 | 10.31 | 11 | 152697 | 16267 | 34787956 |
Rhinitis perennial | 39.59 | 10.31 | 22 | 152686 | 305 | 34803918 |
Synovitis | 39.25 | 10.31 | 7 | 152701 | 14059 | 34790164 |
Tremor | 39.07 | 10.31 | 541 | 152167 | 82046 | 34722177 |
Hyperkalaemia | 39.06 | 10.31 | 163 | 152545 | 69226 | 34734997 |
Psychotic symptom | 39.06 | 10.31 | 43 | 152665 | 1700 | 34802523 |
Drug screen positive | 38.56 | 10.31 | 65 | 152643 | 3878 | 34800345 |
Insomnia | 38.52 | 10.31 | 653 | 152055 | 103254 | 34700969 |
Victim of child abuse | 38.20 | 10.31 | 32 | 152676 | 895 | 34803328 |
Faecaloma | 37.92 | 10.31 | 77 | 152631 | 5300 | 34798923 |
Incoherent | 37.83 | 10.31 | 69 | 152639 | 4383 | 34799840 |
Dyspnoea | 37.50 | 10.31 | 1309 | 151399 | 375473 | 34428750 |
Depression | 37.01 | 10.31 | 613 | 152095 | 96485 | 34707738 |
Pneumonia aspiration | 36.94 | 10.31 | 311 | 152397 | 41592 | 34762631 |
Anxiolytic therapy | 36.80 | 10.31 | 13 | 152695 | 53 | 34804170 |
Self-injurious ideation | 36.80 | 10.31 | 41 | 152667 | 1643 | 34802580 |
Adjustment disorder | 36.67 | 10.31 | 35 | 152673 | 1166 | 34803057 |
Anaphylactic shock | 36.55 | 10.31 | 12 | 152696 | 15929 | 34788294 |
Confabulation | 35.99 | 10.31 | 16 | 152692 | 132 | 34804091 |
Dysphoria | 35.53 | 10.31 | 47 | 152661 | 2255 | 34801968 |
Drug withdrawal convulsions | 35.37 | 10.31 | 34 | 152674 | 1143 | 34803080 |
Diet refusal | 35.21 | 10.31 | 20 | 152688 | 290 | 34803933 |
Drug therapy enhancement | 35.18 | 10.31 | 13 | 152695 | 62 | 34804161 |
Visceral congestion | 35.14 | 10.31 | 26 | 152682 | 604 | 34803619 |
Parathyroid gland enlargement | 35.08 | 10.31 | 16 | 152692 | 141 | 34804082 |
Affective disorder | 35.08 | 10.31 | 66 | 152642 | 4294 | 34799929 |
Respiratory arrest | 34.94 | 10.31 | 226 | 152482 | 27817 | 34776406 |
Iatrogenic injury | 34.58 | 10.31 | 30 | 152678 | 881 | 34803342 |
Cardiac failure | 34.44 | 10.31 | 245 | 152463 | 91003 | 34713220 |
Drug reaction with eosinophilia and systemic symptoms | 34.33 | 10.31 | 57 | 152651 | 32955 | 34771268 |
Hypersensitivity | 33.97 | 10.31 | 144 | 152564 | 60891 | 34743332 |
Cardiac failure congestive | 33.70 | 10.31 | 219 | 152489 | 83051 | 34721172 |
Upper respiratory fungal infection | 33.60 | 10.31 | 16 | 152692 | 157 | 34804066 |
Hepatic cytolysis | 33.08 | 10.31 | 11 | 152697 | 14485 | 34789738 |
Mental disorder | 33.08 | 10.31 | 143 | 152565 | 15066 | 34789157 |
Sexually inappropriate behaviour | 32.84 | 10.31 | 23 | 152685 | 489 | 34803734 |
Pain in extremity | 32.73 | 10.31 | 374 | 152334 | 126139 | 34678084 |
Status epilepticus | 32.51 | 10.31 | 125 | 152583 | 12489 | 34791734 |
Affect lability | 32.47 | 10.31 | 58 | 152650 | 3625 | 34800598 |
Thinking abnormal | 32.12 | 10.31 | 78 | 152630 | 6059 | 34798164 |
Myocardial infarction | 32.09 | 10.31 | 356 | 152352 | 120729 | 34683494 |
Oropharyngeal spasm | 31.08 | 10.31 | 15 | 152693 | 152 | 34804071 |
Muscle spasticity | 30.99 | 10.31 | 75 | 152633 | 5813 | 34798410 |
Angioedema | 30.74 | 10.31 | 74 | 152634 | 37300 | 34766923 |
Hyperammonaemic encephalopathy | 30.68 | 10.31 | 44 | 152664 | 2280 | 34801943 |
Neologism | 30.50 | 10.31 | 8 | 152700 | 7 | 34804216 |
Oral discharge | 30.44 | 10.31 | 14 | 152694 | 126 | 34804097 |
Cholestasis | 30.44 | 10.31 | 44 | 152664 | 26904 | 34777319 |
Psychotic behaviour | 30.31 | 10.31 | 25 | 152683 | 684 | 34803539 |
Hyperprolactinaemia | 30.07 | 10.31 | 36 | 152672 | 1560 | 34802663 |
Lethargy | 30.02 | 10.31 | 293 | 152415 | 40829 | 34763394 |
Mania | 29.39 | 10.31 | 100 | 152608 | 9411 | 34794812 |
Mutism | 29.09 | 10.31 | 27 | 152681 | 868 | 34803355 |
Hangover | 29.04 | 10.31 | 29 | 152679 | 1022 | 34803201 |
Aplastic anaemia | 29.02 | 10.31 | 101 | 152607 | 9615 | 34794608 |
Monoparesis | 28.92 | 10.31 | 43 | 152665 | 2303 | 34801920 |
Hypertonic bladder | 28.68 | 10.31 | 38 | 152670 | 1826 | 34802397 |
Forced expiratory volume | 28.66 | 10.31 | 13 | 152695 | 113 | 34804110 |
Impulsive behaviour | 28.64 | 10.31 | 41 | 152667 | 2121 | 34802102 |
Haematuria | 28.55 | 10.31 | 117 | 152591 | 49949 | 34754274 |
Acute myocardial infarction | 28.52 | 10.31 | 129 | 152579 | 53590 | 34750633 |
Arthropathy | 28.40 | 10.31 | 46 | 152662 | 26861 | 34777362 |
Micturition urgency | 28.03 | 10.31 | 77 | 152631 | 6448 | 34797775 |
Nervousness | 27.78 | 10.31 | 119 | 152589 | 12487 | 34791736 |
Myocardial fibrosis | 27.64 | 10.31 | 30 | 152678 | 1167 | 34803056 |
Anger | 27.60 | 10.31 | 114 | 152594 | 11770 | 34792453 |
Off label use | 27.35 | 10.31 | 1527 | 151181 | 417997 | 34386226 |
Bone marrow failure | 27.29 | 10.31 | 54 | 152654 | 29199 | 34775024 |
Epidural lipomatosis | 27.15 | 10.31 | 28 | 152680 | 1026 | 34803197 |
Intentional product use issue | 26.99 | 10.31 | 152 | 152556 | 59664 | 34744559 |
Transplant rejection | 26.95 | 10.31 | 6 | 152702 | 10305 | 34793918 |
Substance abuse | 26.91 | 10.31 | 84 | 152624 | 7557 | 34796666 |
Arthritis | 26.63 | 10.31 | 61 | 152647 | 31285 | 34772938 |
Amnesia | 26.60 | 10.31 | 203 | 152505 | 26360 | 34777863 |
Diarrhoea | 26.56 | 10.31 | 1413 | 151295 | 388499 | 34415724 |
Anaphylactic reaction | 26.53 | 10.31 | 64 | 152644 | 32237 | 34771986 |
Logorrhoea | 26.44 | 10.31 | 42 | 152666 | 2384 | 34801839 |
Gastrointestinal haemorrhage | 26.36 | 10.31 | 253 | 152455 | 88224 | 34715999 |
Coronary artery disease | 26.24 | 10.31 | 115 | 152593 | 48190 | 34756033 |
Social avoidant behaviour | 26.13 | 10.31 | 48 | 152660 | 3066 | 34801157 |
Erythema | 25.97 | 10.31 | 255 | 152453 | 88525 | 34715698 |
Pleurothotonus | 25.75 | 10.31 | 29 | 152679 | 1176 | 34803047 |
Parkinsonian gait | 25.57 | 10.31 | 20 | 152688 | 506 | 34803717 |
Panic attack | 25.57 | 10.31 | 95 | 152613 | 9337 | 34794886 |
Myocarditis | 25.55 | 10.31 | 123 | 152585 | 13559 | 34790664 |
Psychomotor retardation | 25.42 | 10.31 | 52 | 152656 | 3598 | 34800625 |
Urinary incontinence | 24.68 | 10.31 | 154 | 152554 | 18720 | 34785503 |
Child abuse | 24.67 | 10.31 | 18 | 152690 | 409 | 34803814 |
Balance disorder | 24.65 | 10.31 | 279 | 152429 | 40375 | 34763848 |
Orgasmic sensation decreased | 24.51 | 10.31 | 10 | 152698 | 65 | 34804158 |
Poisoning | 24.36 | 10.31 | 112 | 152596 | 12114 | 34792109 |
Depressed mood | 24.26 | 10.31 | 156 | 152552 | 19161 | 34785062 |
Panic reaction | 24.14 | 10.31 | 31 | 152677 | 1444 | 34802779 |
Oedema peripheral | 24.11 | 10.31 | 373 | 152335 | 119439 | 34684784 |
Alcohol withdrawal syndrome | 23.96 | 10.31 | 31 | 152677 | 1455 | 34802768 |
Pathogen resistance | 23.83 | 10.31 | 6 | 152702 | 9476 | 34794747 |
Hallucination, visual | 23.79 | 10.31 | 146 | 152562 | 17645 | 34786578 |
Rhabdomyolysis | 23.67 | 10.31 | 424 | 152284 | 67739 | 34736484 |
Failure to thrive | 23.63 | 10.31 | 87 | 152621 | 8514 | 34795709 |
Priapism | 23.54 | 10.31 | 61 | 152647 | 4933 | 34799290 |
Communication disorder | 23.29 | 10.31 | 41 | 152667 | 2533 | 34801690 |
Urticaria | 23.28 | 10.31 | 168 | 152540 | 62209 | 34742014 |
Therapeutic product effect decreased | 23.23 | 10.31 | 76 | 152632 | 34667 | 34769556 |
Persecutory delusion | 23.22 | 10.31 | 41 | 152667 | 2539 | 34801684 |
Epstein-Barr virus infection | 23.10 | 10.31 | 3 | 152705 | 7625 | 34796598 |
Tubulointerstitial nephritis | 23.09 | 10.31 | 35 | 152673 | 20989 | 34783234 |
Injection site pain | 22.97 | 10.31 | 90 | 152618 | 38915 | 34765308 |
Eczema | 22.96 | 10.31 | 28 | 152680 | 18408 | 34785815 |
Hyperosmolar state | 22.94 | 10.31 | 17 | 152691 | 396 | 34803827 |
C-reactive protein abnormal | 22.91 | 10.31 | 5 | 152703 | 8705 | 34795518 |
Hyperreflexia | 22.71 | 10.31 | 46 | 152662 | 3160 | 34801063 |
Contraindicated product administered | 22.42 | 10.31 | 37 | 152671 | 21444 | 34782779 |
Memory impairment | 22.22 | 10.31 | 288 | 152420 | 43030 | 34761193 |
Inappropriate antidiuretic hormone secretion | 21.93 | 10.31 | 112 | 152596 | 12641 | 34791582 |
Bipolar disorder | 21.79 | 10.31 | 49 | 152659 | 3620 | 34800603 |
Full blood count abnormal | 21.77 | 10.31 | 148 | 152560 | 18520 | 34785703 |
Ascites | 21.74 | 10.31 | 117 | 152591 | 46454 | 34757769 |
Loss of consciousness | 21.65 | 10.31 | 493 | 152215 | 82174 | 34722049 |
Fear | 21.64 | 10.31 | 97 | 152611 | 10379 | 34793844 |
Drug resistance | 21.58 | 10.31 | 51 | 152657 | 25876 | 34778347 |
Disturbance in attention | 21.52 | 10.31 | 190 | 152518 | 25755 | 34778468 |
Liver disorder | 21.50 | 10.31 | 73 | 152635 | 32924 | 34771299 |
Disorganised speech | 21.46 | 10.31 | 23 | 152685 | 882 | 34803341 |
Plasma cell myeloma | 21.36 | 10.31 | 279 | 152429 | 41758 | 34762465 |
Atrial fibrillation | 21.07 | 10.31 | 392 | 152316 | 122001 | 34682222 |
Cerebral haemorrhage | 20.96 | 10.31 | 80 | 152628 | 34857 | 34769366 |
Haematotoxicity | 20.96 | 10.31 | 5 | 152703 | 8189 | 34796034 |
COVID-19 pneumonia | 20.89 | 10.31 | 26 | 152682 | 16941 | 34787282 |
Middle insomnia | 20.57 | 10.31 | 71 | 152637 | 6731 | 34797492 |
Drug intolerance | 20.54 | 10.31 | 164 | 152544 | 59406 | 34744817 |
Hypoglycaemia | 20.46 | 10.31 | 147 | 152561 | 54493 | 34749730 |
Thrombocytopenia | 20.39 | 10.31 | 523 | 152185 | 155724 | 34648499 |
Soliloquy | 20.25 | 10.31 | 16 | 152692 | 411 | 34803812 |
Blood creatine phosphokinase | 20.25 | 10.31 | 10 | 152698 | 107 | 34804116 |
Sexual dysfunction | 20.12 | 10.31 | 67 | 152641 | 6236 | 34797987 |
Drug eruption | 20.09 | 10.31 | 35 | 152673 | 19863 | 34784360 |
Melaena | 19.97 | 10.31 | 83 | 152625 | 35297 | 34768926 |
Negative thoughts | 19.93 | 10.31 | 19 | 152689 | 632 | 34803591 |
Flight of ideas | 19.79 | 10.31 | 15 | 152693 | 362 | 34803861 |
Blood sodium decreased | 19.65 | 10.31 | 130 | 152578 | 16121 | 34788102 |
Visual acuity reduced | 19.62 | 10.31 | 25 | 152683 | 16124 | 34788099 |
Illusion | 19.58 | 10.31 | 21 | 152687 | 806 | 34803417 |
Proteinuria | 19.55 | 10.31 | 32 | 152676 | 18610 | 34785613 |
Cough | 19.47 | 10.31 | 503 | 152205 | 149637 | 34654586 |
Oculogyric crisis | 19.45 | 10.31 | 29 | 152679 | 1557 | 34802666 |
Pyrexia | 19.36 | 10.31 | 1225 | 151483 | 331788 | 34472435 |
Angina pectoris | 19.35 | 10.31 | 71 | 152637 | 31292 | 34772931 |
Nephropathy toxic | 19.24 | 10.31 | 16 | 152692 | 12572 | 34791651 |
Jaundice | 19.13 | 10.31 | 73 | 152635 | 31809 | 34772414 |
Premature ejaculation | 19.11 | 10.31 | 10 | 152698 | 122 | 34804101 |
Cerebral infarction | 19.09 | 10.31 | 59 | 152649 | 27396 | 34776827 |
Pulmonary fibrosis | 18.90 | 10.31 | 32 | 152676 | 18364 | 34785859 |
Intentional product misuse | 18.88 | 10.31 | 292 | 152416 | 45319 | 34758904 |
Purple glove syndrome | 18.87 | 10.31 | 8 | 152700 | 58 | 34804165 |
Schizoaffective disorder | 18.82 | 10.31 | 26 | 152682 | 1301 | 34802922 |
Cerebrovascular accident | 18.81 | 10.31 | 259 | 152449 | 84552 | 34719671 |
Sexual relationship change | 18.64 | 10.31 | 6 | 152702 | 17 | 34804206 |
Rhinalgia | 18.62 | 10.31 | 23 | 152685 | 1030 | 34803193 |
Generalised tonic-clonic seizure | 18.57 | 10.31 | 157 | 152551 | 21017 | 34783206 |
Injection site swelling | 18.44 | 10.31 | 14 | 152694 | 11513 | 34792710 |
Growth hormone deficiency | 18.38 | 10.31 | 13 | 152695 | 281 | 34803942 |
Cognitive disorder | 18.35 | 10.31 | 199 | 152509 | 28494 | 34775729 |
Thought insertion | 18.27 | 10.31 | 5 | 152703 | 6 | 34804217 |
Renal disorder | 18.26 | 10.31 | 54 | 152654 | 25426 | 34778797 |
Dysphagia | 18.24 | 10.31 | 378 | 152330 | 62003 | 34742220 |
Hyperventilation | 18.23 | 10.31 | 39 | 152669 | 2785 | 34801438 |
Herpes zoster | 18.02 | 10.31 | 83 | 152625 | 34316 | 34769907 |
Appendicitis | 17.91 | 10.31 | 23 | 152685 | 14784 | 34789439 |
Haematuria traumatic | 17.79 | 10.31 | 11 | 152697 | 188 | 34804035 |
Immune reconstitution inflammatory syndrome | 17.75 | 10.31 | 8 | 152700 | 8751 | 34795472 |
Basal cell carcinoma | 17.73 | 10.31 | 37 | 152671 | 19621 | 34784602 |
Infection | 17.62 | 10.31 | 285 | 152423 | 90630 | 34713593 |
Emotional disorder | 17.57 | 10.31 | 60 | 152648 | 5656 | 34798567 |
Perseveration | 17.55 | 10.31 | 9 | 152699 | 105 | 34804118 |
Aspiration | 17.54 | 10.31 | 102 | 152606 | 12092 | 34792131 |
Infusion related reaction | 17.41 | 10.31 | 148 | 152560 | 52909 | 34751314 |
Nasal congestion | 17.16 | 10.31 | 48 | 152660 | 23009 | 34781214 |
Neutropenic sepsis | 17.05 | 10.31 | 21 | 152687 | 13746 | 34790477 |
Floppy infant | 17.04 | 10.31 | 9 | 152699 | 112 | 34804111 |
Staring | 16.78 | 10.31 | 26 | 152682 | 1444 | 34802779 |
Fall | 16.65 | 10.31 | 1063 | 151645 | 201822 | 34602401 |
Oesophageal carcinoma | 16.63 | 10.31 | 10 | 152698 | 9294 | 34794929 |
Porphyria acute | 16.45 | 10.31 | 13 | 152695 | 334 | 34803889 |
Dyspnoea exertional | 16.42 | 10.31 | 116 | 152592 | 43163 | 34761060 |
Pressure of speech | 16.22 | 10.31 | 15 | 152693 | 480 | 34803743 |
Hypoxia | 16.15 | 10.31 | 334 | 152374 | 54761 | 34749462 |
Homicidal ideation | 16.13 | 10.31 | 36 | 152672 | 2646 | 34801577 |
Loose associations | 16.04 | 10.31 | 7 | 152701 | 55 | 34804168 |
Skin ulcer | 15.98 | 10.31 | 47 | 152661 | 22169 | 34782054 |
Coordination abnormal | 15.96 | 10.31 | 71 | 152637 | 7573 | 34796650 |
Antipsychotic drug level above therapeutic | 15.78 | 10.31 | 23 | 152685 | 1210 | 34803013 |
Testicular atrophy | 15.75 | 10.31 | 16 | 152692 | 576 | 34803647 |
Hypomania | 15.71 | 10.31 | 33 | 152675 | 2326 | 34801897 |
Altered state of consciousness | 15.68 | 10.31 | 161 | 152547 | 22732 | 34781491 |
Venous angioma of brain | 15.54 | 10.31 | 6 | 152702 | 33 | 34804190 |
Apnoea | 15.53 | 10.31 | 64 | 152644 | 6600 | 34797623 |
Glycosylated haemoglobin increased | 15.52 | 10.31 | 16 | 152692 | 11344 | 34792879 |
Ventricular fibrillation | 15.49 | 10.31 | 50 | 152658 | 22904 | 34781319 |
Rebound effect | 15.44 | 10.31 | 40 | 152668 | 3234 | 34800989 |
Chronic kidney disease | 15.37 | 10.31 | 111 | 152597 | 41099 | 34763124 |
Megacolon | 15.31 | 10.31 | 28 | 152680 | 1782 | 34802441 |
Tachyphrenia | 15.27 | 10.31 | 23 | 152685 | 1246 | 34802977 |
Somatic hallucination | 15.25 | 10.31 | 6 | 152702 | 35 | 34804188 |
Posturing | 15.25 | 10.31 | 15 | 152693 | 519 | 34803704 |
Self esteem decreased | 15.13 | 10.31 | 15 | 152693 | 524 | 34803699 |
Suicidal behaviour | 15.07 | 10.31 | 25 | 152683 | 1472 | 34802751 |
Blood urea nitrogen/creatinine ratio decreased | 14.97 | 10.31 | 6 | 152702 | 37 | 34804186 |
Immunosuppressant drug level increased | 14.90 | 10.31 | 4 | 152704 | 6051 | 34798172 |
Fluid replacement | 14.81 | 10.31 | 10 | 152698 | 200 | 34804023 |
Slow speech | 14.77 | 10.31 | 22 | 152686 | 1180 | 34803043 |
Pneumocystis jirovecii pneumonia | 14.69 | 10.31 | 41 | 152667 | 19669 | 34784554 |
Dystonic tremor | 14.43 | 10.31 | 10 | 152698 | 209 | 34804014 |
Juvenile idiopathic arthritis | 14.38 | 10.31 | 28 | 152680 | 1869 | 34802354 |
Frequent bowel movements | 14.32 | 10.31 | 21 | 152687 | 12766 | 34791457 |
Hypogammaglobulinaemia | 14.28 | 10.31 | 8 | 152700 | 7732 | 34796491 |
Injection site erythema | 14.28 | 10.31 | 30 | 152678 | 15869 | 34788354 |
Myalgia | 14.27 | 10.31 | 270 | 152438 | 83840 | 34720383 |
Tuberculosis | 14.26 | 10.31 | 10 | 152698 | 8567 | 34795656 |
Renal failure | 14.22 | 10.31 | 448 | 152260 | 130109 | 34674114 |
Manic symptom | 14.20 | 10.31 | 8 | 152700 | 114 | 34804109 |
Shoshin beriberi | 14.17 | 10.31 | 7 | 152701 | 75 | 34804148 |
Skin necrosis | 14.15 | 10.31 | 4 | 152704 | 5849 | 34798374 |
Colitis ulcerative | 14.15 | 10.31 | 32 | 152676 | 16488 | 34787735 |
Drop attacks | 14.15 | 10.31 | 15 | 152693 | 568 | 34803655 |
Gingival oedema | 14.11 | 10.31 | 4 | 152704 | 6 | 34804217 |
Feeling jittery | 14.09 | 10.31 | 44 | 152664 | 3959 | 34800264 |
Spasmodic dysphonia | 13.98 | 10.31 | 10 | 152698 | 220 | 34804003 |
Lip swelling | 13.89 | 10.31 | 31 | 152677 | 16049 | 34788174 |
End stage renal disease | 13.87 | 10.31 | 11 | 152697 | 8850 | 34795373 |
Hepatic failure | 13.87 | 10.31 | 91 | 152617 | 34440 | 34769783 |
Derealisation | 13.85 | 10.31 | 15 | 152693 | 582 | 34803641 |
Staphylococcal infection | 13.84 | 10.31 | 85 | 152623 | 32675 | 34771548 |
Cardiac disorder | 13.84 | 10.31 | 121 | 152587 | 43005 | 34761218 |
Head banging | 13.63 | 10.31 | 9 | 152699 | 173 | 34804050 |
Pneumonia | 13.62 | 10.31 | 1382 | 151326 | 361245 | 34442978 |
Myelodysplastic syndrome | 13.55 | 10.31 | 41 | 152667 | 19167 | 34785056 |
Hepatocellular carcinoma | 13.52 | 10.31 | 8 | 152700 | 7501 | 34796722 |
Electroencephalogram abnormal | 13.51 | 10.31 | 32 | 152676 | 2446 | 34801777 |
Reduced facial expression | 13.45 | 10.31 | 20 | 152688 | 1071 | 34803152 |
Hypercapnia | 13.38 | 10.31 | 45 | 152663 | 4210 | 34800013 |
Vascular stenosis | 13.20 | 10.31 | 9 | 152699 | 183 | 34804040 |
Nephrolithiasis | 13.18 | 10.31 | 78 | 152630 | 30255 | 34773968 |
Hypocalcaemia | 13.08 | 10.31 | 58 | 152650 | 24231 | 34779992 |
Progressive multifocal leukoencephalopathy | 13.06 | 10.31 | 14 | 152694 | 9750 | 34794473 |
Congenital pulmonary valve atresia | 13.05 | 10.31 | 6 | 152702 | 54 | 34804169 |
Malaise | 13.05 | 10.31 | 671 | 152037 | 185154 | 34619069 |
Poor sucking reflex | 13.00 | 10.31 | 11 | 152697 | 312 | 34803911 |
Haemophagocytic lymphohistiocytosis | 12.94 | 10.31 | 23 | 152685 | 12950 | 34791273 |
Grandiosity | 12.85 | 10.31 | 11 | 152697 | 317 | 34803906 |
Blood alkaline phosphatase decreased | 12.83 | 10.31 | 17 | 152691 | 817 | 34803406 |
Lactic acidosis | 12.80 | 10.31 | 94 | 152614 | 34678 | 34769545 |
Muscle mass | 12.75 | 10.31 | 10 | 152698 | 254 | 34803969 |
Skin laceration | 12.75 | 10.31 | 96 | 152612 | 12413 | 34791810 |
Blood osmolarity increased | 12.74 | 10.31 | 12 | 152696 | 393 | 34803830 |
Lung disorder | 12.67 | 10.31 | 94 | 152614 | 34602 | 34769621 |
Obesity | 12.66 | 10.31 | 98 | 152610 | 12780 | 34791443 |
Mood swings | 12.63 | 10.31 | 68 | 152640 | 7833 | 34796390 |
Hallucination, olfactory | 12.62 | 10.31 | 9 | 152699 | 197 | 34804026 |
Nerve degeneration | 12.55 | 10.31 | 9 | 152699 | 199 | 34804024 |
Clumsiness | 12.45 | 10.31 | 25 | 152683 | 1707 | 34802516 |
Emotional distress | 12.44 | 10.31 | 110 | 152598 | 14916 | 34789307 |
Hepatotoxicity | 12.38 | 10.31 | 50 | 152658 | 21435 | 34782788 |
Hyperchloraemia | 12.24 | 10.31 | 13 | 152695 | 493 | 34803730 |
Vasculitis | 12.22 | 10.31 | 19 | 152689 | 11277 | 34792946 |
Prescribed overdose | 12.17 | 10.31 | 84 | 152624 | 10563 | 34793660 |
Blood prolactin increased | 12.17 | 10.31 | 25 | 152683 | 1735 | 34802488 |
Waxy flexibility | 12.12 | 10.31 | 7 | 152701 | 105 | 34804118 |
Skin toxicity | 12.08 | 10.31 | 3 | 152705 | 4781 | 34799442 |
Bronchopulmonary aspergillosis | 12.07 | 10.31 | 29 | 152679 | 14630 | 34789593 |
Pulmonary tuberculosis | 11.96 | 10.31 | 3 | 152705 | 4751 | 34799472 |
Neutrophil count increased | 11.94 | 10.31 | 121 | 152587 | 17025 | 34787198 |
Lithiasis | 11.93 | 10.31 | 6 | 152702 | 67 | 34804156 |
Gastrointestinal disorder | 11.91 | 10.31 | 93 | 152615 | 33855 | 34770368 |
Therapeutic response decreased | 11.90 | 10.31 | 77 | 152631 | 29236 | 34774987 |
Obsessive-compulsive disorder | 11.86 | 10.31 | 52 | 152656 | 5512 | 34798711 |
Grimacing | 11.84 | 10.31 | 10 | 152698 | 283 | 34803940 |
Drooling | 11.74 | 10.31 | 37 | 152671 | 3345 | 34800878 |
Peritonitis bacterial | 11.74 | 10.31 | 6 | 152702 | 6104 | 34798119 |
Pseudomonal bacteraemia | 11.74 | 10.31 | 22 | 152686 | 1427 | 34802796 |
Ureteric obstruction | 11.68 | 10.31 | 20 | 152688 | 1208 | 34803015 |
Neonatal tachypnoea | 11.63 | 10.31 | 8 | 152700 | 165 | 34804058 |
Selective mutism | 11.62 | 10.31 | 6 | 152702 | 71 | 34804152 |
Renal cancer | 11.62 | 10.31 | 10 | 152698 | 7725 | 34796498 |
Dehydration | 11.58 | 10.31 | 686 | 152022 | 129283 | 34674940 |
Delirium tremens | 11.53 | 10.31 | 14 | 152694 | 616 | 34803607 |
Nephrotic syndrome | 11.52 | 10.31 | 9 | 152699 | 7294 | 34796929 |
Creutzfeldt-Jakob disease | 11.49 | 10.31 | 5 | 152703 | 39 | 34804184 |
Acute stress disorder | 11.47 | 10.31 | 8 | 152700 | 169 | 34804054 |
Drug hypersensitivity | 11.46 | 10.31 | 266 | 152442 | 80263 | 34723960 |
Septic shock | 11.45 | 10.31 | 233 | 152475 | 71601 | 34732622 |
Echolalia | 11.40 | 10.31 | 10 | 152698 | 298 | 34803925 |
Transient acantholytic dermatosis | 11.40 | 10.31 | 7 | 152701 | 118 | 34804105 |
Arachnoid cyst | 11.40 | 10.31 | 9 | 152699 | 231 | 34803992 |
Physical assault | 11.36 | 10.31 | 19 | 152689 | 1126 | 34803097 |
Cytotoxic oedema | 11.31 | 10.31 | 8 | 152700 | 173 | 34804050 |
Tangentiality | 11.30 | 10.31 | 7 | 152701 | 120 | 34804103 |
Central nervous system lesion | 11.28 | 10.31 | 57 | 152651 | 6406 | 34797817 |
Pulse pressure increased | 11.25 | 10.31 | 3 | 152705 | 3 | 34804220 |
Thought withdrawal | 11.25 | 10.31 | 3 | 152705 | 3 | 34804220 |
Anorectal operation | 11.25 | 10.31 | 3 | 152705 | 3 | 34804220 |
Hypertensive crisis | 11.21 | 10.31 | 13 | 152695 | 8738 | 34795485 |
Mucormycosis | 11.17 | 10.31 | 6 | 152702 | 5936 | 34798287 |
Feelings of worthlessness | 11.10 | 10.31 | 10 | 152698 | 309 | 34803914 |
Pollakiuria | 11.03 | 10.31 | 133 | 152575 | 19541 | 34784682 |
Autoimmune haemolytic anaemia | 11.01 | 10.31 | 3 | 152705 | 4493 | 34799730 |
Device issue | 11.00 | 10.31 | 16 | 152692 | 9761 | 34794462 |
Platelet transfusion | 10.94 | 10.31 | 22 | 152686 | 1504 | 34802719 |
Foetal exposure during pregnancy | 10.89 | 10.31 | 110 | 152598 | 37991 | 34766232 |
Body temperature increased | 10.89 | 10.31 | 120 | 152588 | 17248 | 34786975 |
Anal incontinence | 10.87 | 10.31 | 65 | 152643 | 7784 | 34796439 |
Cerebral atrophy | 10.83 | 10.31 | 44 | 152664 | 4508 | 34799715 |
Dissociation | 10.82 | 10.31 | 23 | 152685 | 1635 | 34802588 |
Pneumonitis chemical | 10.81 | 10.31 | 8 | 152700 | 186 | 34804037 |
Impaired reasoning | 10.77 | 10.31 | 7 | 152701 | 131 | 34804092 |
Impaired quality of life | 10.76 | 10.31 | 6 | 152702 | 5812 | 34798411 |
Lymphocyte count abnormal | 10.73 | 10.31 | 19 | 152689 | 1179 | 34803044 |
Drug ineffective for unapproved indication | 10.66 | 10.31 | 154 | 152554 | 23561 | 34780662 |
General physical health deterioration | 10.62 | 10.31 | 455 | 152253 | 127814 | 34676409 |
Drug-induced liver injury | 10.58 | 10.31 | 78 | 152630 | 28754 | 34775469 |
Injection site pruritus | 10.52 | 10.31 | 9 | 152699 | 6974 | 34797249 |
Periorbital pain | 10.51 | 10.31 | 4 | 152704 | 21 | 34804202 |
Thrombosis | 10.51 | 10.31 | 156 | 152552 | 50302 | 34753921 |
Erectile dysfunction | 10.49 | 10.31 | 137 | 152571 | 20500 | 34783723 |
Thrombotic microangiopathy | 10.46 | 10.31 | 19 | 152689 | 10611 | 34793612 |
Crying | 10.44 | 10.31 | 52 | 152656 | 5810 | 34798413 |
Drug tolerance | 10.44 | 10.31 | 32 | 152676 | 2850 | 34801373 |
Hypophagia | 10.40 | 10.31 | 155 | 152553 | 23867 | 34780356 |
Haematochezia | 10.35 | 10.31 | 142 | 152566 | 46392 | 34757831 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Sopor | 2747.20 | 9.53 | 1775 | 364468 | 31235 | 79346910 |
Drug abuse | 1495.34 | 9.53 | 2680 | 363563 | 160011 | 79218134 |
Completed suicide | 828.54 | 9.53 | 2747 | 363496 | 243020 | 79135125 |
Neuroleptic malignant syndrome | 798.55 | 9.53 | 798 | 365445 | 26761 | 79351384 |
Intentional self-injury | 752.53 | 9.53 | 834 | 365409 | 31585 | 79346560 |
Agitation | 695.56 | 9.53 | 1463 | 364780 | 98252 | 79279893 |
Suicide attempt | 625.78 | 9.53 | 1257 | 364986 | 81675 | 79296470 |
Bradyphrenia | 624.97 | 9.53 | 462 | 365781 | 10178 | 79367967 |
Somnolence | 541.88 | 9.53 | 2354 | 363889 | 236627 | 79141518 |
Catatonia | 529.63 | 9.53 | 387 | 365856 | 8369 | 79369776 |
Delirium | 477.23 | 9.53 | 1141 | 365102 | 83486 | 79294659 |
Intentional overdose | 469.85 | 9.53 | 1305 | 364938 | 104655 | 79273490 |
Overdose | 423.08 | 9.53 | 1822 | 364421 | 182384 | 79195761 |
Psychotic disorder | 359.28 | 9.53 | 666 | 365577 | 40736 | 79337409 |
Toxicity to various agents | 315.03 | 9.53 | 3137 | 363106 | 418403 | 78959742 |
Drug withdrawal syndrome | 311.99 | 9.53 | 567 | 365676 | 34151 | 79343994 |
Coma | 311.26 | 9.53 | 1094 | 365149 | 99555 | 79278590 |
Aggression | 297.97 | 9.53 | 697 | 365546 | 50261 | 79327884 |
Confusional state | 291.87 | 9.53 | 2474 | 363769 | 315523 | 79062622 |
Anxiety | 264.24 | 9.53 | 2000 | 364243 | 246512 | 79131633 |
Extrapyramidal disorder | 261.59 | 9.53 | 414 | 365829 | 22265 | 79355880 |
Drug dependence | 259.83 | 9.53 | 577 | 365666 | 40192 | 79337953 |
Serotonin syndrome | 259.04 | 9.53 | 612 | 365631 | 44415 | 79333730 |
Disorientation | 243.29 | 9.53 | 737 | 365506 | 62039 | 79316106 |
Restlessness | 240.92 | 9.53 | 607 | 365636 | 45885 | 79332260 |
Suicidal ideation | 240.51 | 9.53 | 835 | 365408 | 75505 | 79302640 |
Sedation | 237.70 | 9.53 | 647 | 365596 | 51248 | 79326897 |
Respiratory depression | 223.02 | 9.53 | 431 | 365812 | 27199 | 79350946 |
Hallucination, auditory | 217.27 | 9.53 | 362 | 365881 | 20331 | 79357814 |
Drug interaction | 211.98 | 9.53 | 2871 | 363372 | 412312 | 78965833 |
Tachycardia | 200.40 | 9.53 | 1451 | 364792 | 176317 | 79201828 |
Depressed level of consciousness | 199.09 | 9.53 | 926 | 365317 | 95726 | 79282419 |
Dysarthria | 194.53 | 9.53 | 718 | 365525 | 66904 | 79311241 |
Joint swelling | 192.96 | 9.53 | 679 | 365564 | 287967 | 79090178 |
Poisoning | 190.42 | 9.53 | 383 | 365860 | 24889 | 79353256 |
Febrile neutropenia | 188.92 | 9.53 | 1753 | 364490 | 229246 | 79148899 |
Muscle rigidity | 186.66 | 9.53 | 331 | 365912 | 19551 | 79358594 |
Akathisia | 185.66 | 9.53 | 265 | 365978 | 12994 | 79365151 |
Schizophrenia | 185.22 | 9.53 | 287 | 365956 | 15153 | 79362992 |
Speech disorder | 184.22 | 9.53 | 610 | 365633 | 53835 | 79324310 |
Bradykinesia | 176.48 | 9.53 | 201 | 366042 | 7842 | 79370303 |
Interstitial lung disease | 171.97 | 9.53 | 158 | 366085 | 112442 | 79265703 |
Delusion | 162.90 | 9.53 | 317 | 365926 | 20106 | 79358039 |
Psychomotor hyperactivity | 162.70 | 9.53 | 284 | 365959 | 16565 | 79361580 |
Arthralgia | 160.81 | 9.53 | 1765 | 364478 | 570038 | 78808107 |
Contraindicated product administered | 160.55 | 9.53 | 299 | 365944 | 157239 | 79220906 |
Drug intolerance | 159.18 | 9.53 | 648 | 365595 | 263471 | 79114674 |
Mental status changes | 154.03 | 9.53 | 663 | 365580 | 66296 | 79311849 |
Abnormal behaviour | 152.92 | 9.53 | 440 | 365803 | 35981 | 79342164 |
Drug ineffective | 151.36 | 9.53 | 3797 | 362446 | 1077116 | 78301029 |
COVID-19 | 147.17 | 9.53 | 315 | 365928 | 157359 | 79220786 |
Mania | 143.91 | 9.53 | 282 | 365961 | 17978 | 79360167 |
Rash | 140.50 | 9.53 | 1843 | 364400 | 576515 | 78801630 |
Pneumonia aspiration | 140.39 | 9.53 | 645 | 365598 | 66322 | 79311823 |
Withdrawal syndrome | 139.52 | 9.53 | 351 | 365892 | 26503 | 79351642 |
Arthropathy | 134.78 | 9.53 | 393 | 365850 | 176718 | 79201427 |
Hypersensitivity | 134.34 | 9.53 | 683 | 365560 | 261556 | 79116589 |
Therapeutic product effect decreased | 131.05 | 9.53 | 355 | 365888 | 163508 | 79214637 |
Seizure | 128.63 | 9.53 | 1380 | 364863 | 187454 | 79190691 |
Synovitis | 123.23 | 9.53 | 323 | 365920 | 150411 | 79227734 |
Mydriasis | 123.04 | 9.53 | 259 | 365984 | 17384 | 79360761 |
Treatment failure | 122.08 | 9.53 | 389 | 365854 | 170097 | 79208048 |
Tremor | 120.54 | 9.53 | 1253 | 364990 | 168830 | 79209315 |
Psychomotor retardation | 118.19 | 9.53 | 144 | 366099 | 6040 | 79372105 |
Rheumatoid arthritis | 115.45 | 9.53 | 528 | 365715 | 207942 | 79170203 |
Unresponsive to stimuli | 115.21 | 9.53 | 535 | 365708 | 55253 | 79322892 |
Respiratory arrest | 114.54 | 9.53 | 546 | 365697 | 57004 | 79321141 |
Salivary hypersecretion | 112.49 | 9.53 | 220 | 366023 | 14004 | 79364141 |
Myelosuppression | 110.06 | 9.53 | 25 | 366218 | 40271 | 79337874 |
Electrocardiogram QT prolonged | 109.50 | 9.53 | 751 | 365492 | 89635 | 79288510 |
Hypokinesia | 108.45 | 9.53 | 258 | 365985 | 18802 | 79359343 |
Hallucination | 103.61 | 9.53 | 712 | 365531 | 85033 | 79293112 |
Pain | 100.65 | 9.53 | 2463 | 363780 | 701339 | 78676806 |
Slow speech | 99.32 | 9.53 | 86 | 366157 | 2392 | 79375753 |
Dystonia | 98.17 | 9.53 | 267 | 365976 | 21132 | 79357013 |
Off label use | 98.14 | 9.53 | 3300 | 362943 | 903915 | 78474230 |
Paranoia | 96.80 | 9.53 | 250 | 365993 | 19182 | 79358963 |
Status epilepticus | 95.13 | 9.53 | 292 | 365951 | 24749 | 79353396 |
Mutism | 94.42 | 9.53 | 82 | 366161 | 2290 | 79375855 |
Stupor | 92.78 | 9.53 | 135 | 366108 | 6737 | 79371408 |
Sinus tachycardia | 91.53 | 9.53 | 374 | 365869 | 36534 | 79341611 |
Miosis | 91.22 | 9.53 | 215 | 366028 | 15574 | 79362571 |
Depression | 91.02 | 9.53 | 1450 | 364793 | 215340 | 79162805 |
Cytomegalovirus infection | 89.22 | 9.53 | 42 | 366201 | 42602 | 79335543 |
Infusion related reaction | 85.60 | 9.53 | 662 | 365581 | 229575 | 79148570 |
Psoriasis | 85.22 | 9.53 | 177 | 366066 | 89410 | 79288735 |
Derealisation | 84.47 | 9.53 | 66 | 366177 | 1583 | 79376562 |
Dyskinesia | 83.51 | 9.53 | 417 | 365826 | 44356 | 79333789 |
Swelling | 83.46 | 9.53 | 617 | 365626 | 216094 | 79162051 |
Parkinsonism | 82.24 | 9.53 | 213 | 366030 | 16371 | 79361774 |
Drug hypersensitivity | 82.09 | 9.53 | 927 | 365316 | 297989 | 79080156 |
Mobility decreased | 81.13 | 9.53 | 288 | 365955 | 121887 | 79256258 |
Product dose omission issue | 81.07 | 9.53 | 736 | 365507 | 246801 | 79131344 |
Systemic lupus erythematosus | 80.17 | 9.53 | 286 | 365957 | 120863 | 79257282 |
Granulocytopenia | 79.93 | 9.53 | 168 | 366075 | 11263 | 79366882 |
Mental disorder | 79.86 | 9.53 | 320 | 365923 | 30982 | 79347163 |
Substance abuse | 79.86 | 9.53 | 160 | 366083 | 10366 | 79367779 |
Pruritus | 77.52 | 9.53 | 1310 | 364933 | 393338 | 78984807 |
Hypothermia | 77.06 | 9.53 | 255 | 365988 | 22491 | 79355654 |
Drooling | 76.40 | 9.53 | 114 | 366129 | 5820 | 79372325 |
Hand deformity | 75.15 | 9.53 | 236 | 366007 | 103683 | 79274462 |
Alopecia | 74.84 | 9.53 | 690 | 365553 | 230665 | 79147480 |
Peripheral swelling | 74.08 | 9.53 | 836 | 365407 | 268781 | 79109364 |
Acute kidney injury | 72.41 | 9.53 | 1824 | 364419 | 517580 | 78860565 |
Mental impairment | 72.33 | 9.53 | 222 | 366021 | 18814 | 79359331 |
Gastric pH decreased | 72.07 | 9.53 | 47 | 366196 | 839 | 79377306 |
Persecutory delusion | 71.52 | 9.53 | 100 | 366143 | 4809 | 79373336 |
Loss of consciousness | 70.35 | 9.53 | 1123 | 365120 | 166820 | 79211325 |
Anaphylactic shock | 70.01 | 9.53 | 39 | 366204 | 35957 | 79342188 |
Hepatic function abnormal | 69.06 | 9.53 | 145 | 366098 | 72962 | 79305183 |
Ataxia | 68.77 | 9.53 | 262 | 365981 | 24777 | 79353368 |
Dissociation | 67.87 | 9.53 | 88 | 366155 | 3933 | 79374212 |
Tardive dyskinesia | 67.77 | 9.53 | 150 | 366093 | 10421 | 79367724 |
Erythema | 67.54 | 9.53 | 677 | 365566 | 222613 | 79155532 |
Bezoar | 67.32 | 9.53 | 72 | 366171 | 2616 | 79375529 |
Pemphigus | 67.28 | 9.53 | 233 | 366010 | 99349 | 79278796 |
Cardiac arrest | 66.63 | 9.53 | 1136 | 365107 | 170960 | 79207185 |
Pain in extremity | 64.62 | 9.53 | 1232 | 365011 | 363306 | 79014839 |
Homicide | 64.09 | 9.53 | 49 | 366194 | 1137 | 79377008 |
Injection site erythema | 63.55 | 9.53 | 168 | 366075 | 78029 | 79300116 |
Hyperammonaemic encephalopathy | 63.19 | 9.53 | 93 | 366150 | 4689 | 79373456 |
Blood creatine phosphokinase increased | 63.00 | 9.53 | 519 | 365724 | 65571 | 79312574 |
Major depression | 62.81 | 9.53 | 132 | 366111 | 8848 | 79369297 |
Device expulsion | 61.40 | 9.53 | 21 | 366222 | 25840 | 79352305 |
Hallucinations, mixed | 61.11 | 9.53 | 112 | 366131 | 6787 | 79371358 |
Feeling of despair | 61.05 | 9.53 | 70 | 366173 | 2751 | 79375394 |
Renal impairment | 60.83 | 9.53 | 449 | 365794 | 157334 | 79220811 |
Hallucination, visual | 59.75 | 9.53 | 303 | 365940 | 32426 | 79345719 |
Antipsychotic drug level increased | 59.59 | 9.53 | 102 | 366141 | 5855 | 79372290 |
Incontinence | 59.34 | 9.53 | 171 | 366072 | 13993 | 79364152 |
Infection | 58.95 | 9.53 | 769 | 365474 | 240943 | 79137202 |
Disorganised speech | 58.92 | 9.53 | 60 | 366183 | 2057 | 79376088 |
Delusion of grandeur | 58.00 | 9.53 | 50 | 366193 | 1382 | 79376763 |
Hypoxia | 57.95 | 9.53 | 727 | 365516 | 102516 | 79275629 |
Withdrawal catatonia | 57.92 | 9.53 | 25 | 366218 | 180 | 79377965 |
Drug eruption | 57.70 | 9.53 | 70 | 366173 | 43865 | 79334280 |
Hepatic enzyme increased | 57.17 | 9.53 | 549 | 365694 | 182061 | 79196084 |
Injection site pain | 56.75 | 9.53 | 356 | 365887 | 129482 | 79248663 |
Prostate cancer | 56.57 | 9.53 | 42 | 366201 | 33226 | 79344919 |
Skin necrosis | 56.35 | 9.53 | 8 | 366235 | 18079 | 79360066 |
Hyperreflexia | 56.05 | 9.53 | 121 | 366122 | 8264 | 79369881 |
Cogwheel rigidity | 55.94 | 9.53 | 70 | 366173 | 3018 | 79375127 |
Depersonalisation/derealisation disorder | 55.92 | 9.53 | 55 | 366188 | 1807 | 79376338 |
Refusal of treatment by patient | 55.87 | 9.53 | 126 | 366117 | 8865 | 79369280 |
Emotional disorder | 53.93 | 9.53 | 167 | 366076 | 14220 | 79363925 |
Anaemia | 53.87 | 9.53 | 1594 | 364649 | 443421 | 78934724 |
Abdominal discomfort | 53.25 | 9.53 | 820 | 365423 | 249907 | 79128238 |
Tenosynovitis | 53.14 | 9.53 | 5 | 366238 | 15549 | 79362596 |
C-reactive protein increased | 52.74 | 9.53 | 361 | 365882 | 128666 | 79249479 |
Fall | 52.10 | 9.53 | 2738 | 363505 | 484891 | 78893254 |
Anti-cyclic citrullinated peptide antibody positive | 50.64 | 9.53 | 203 | 366040 | 82940 | 79295205 |
Hepatic cytolysis | 50.56 | 9.53 | 31 | 366212 | 27120 | 79351025 |
Coma scale abnormal | 49.94 | 9.53 | 118 | 366125 | 8560 | 79369585 |
Apnoea | 49.71 | 9.53 | 142 | 366101 | 11562 | 79366583 |
Computerised tomogram thorax | 49.67 | 9.53 | 29 | 366214 | 421 | 79377724 |
Therapeutic response decreased | 49.62 | 9.53 | 150 | 366093 | 66703 | 79311442 |
Brain injury | 49.17 | 9.53 | 140 | 366103 | 11377 | 79366768 |
Affective disorder | 48.84 | 9.53 | 114 | 366129 | 8205 | 79369940 |
Visceral congestion | 48.40 | 9.53 | 38 | 366205 | 918 | 79377227 |
Arthritis | 48.16 | 9.53 | 319 | 365924 | 114561 | 79263584 |
Insomnia | 48.05 | 9.53 | 1470 | 364773 | 243700 | 79134445 |
Red blood cell sedimentation rate increased | 47.83 | 9.53 | 86 | 366157 | 45856 | 79332289 |
Disturbance in attention | 47.38 | 9.53 | 397 | 365846 | 50404 | 79327741 |
Computerised tomogram thorax abnormal | 47.32 | 9.53 | 57 | 366186 | 2362 | 79375783 |
Cardiac failure congestive | 46.76 | 9.53 | 423 | 365820 | 141979 | 79236166 |
Therapeutic product effect incomplete | 46.40 | 9.53 | 421 | 365822 | 141224 | 79236921 |
Feeling jittery | 46.24 | 9.53 | 147 | 366096 | 12694 | 79365451 |
Incoherent | 45.81 | 9.53 | 106 | 366137 | 7586 | 79370559 |
Electrocardiogram QRS complex prolonged | 45.59 | 9.53 | 131 | 366112 | 10702 | 79367443 |
Negativism | 45.20 | 9.53 | 35 | 366208 | 828 | 79377317 |
Somatic symptom disorder | 45.15 | 9.53 | 57 | 366186 | 2480 | 79375665 |
Mood swings | 45.05 | 9.53 | 196 | 366047 | 19684 | 79358461 |
Angioedema | 44.83 | 9.53 | 188 | 366055 | 75847 | 79302298 |
Irritability | 44.67 | 9.53 | 333 | 365910 | 40811 | 79337334 |
Drug withdrawal convulsions | 44.56 | 9.53 | 53 | 366190 | 2167 | 79375978 |
Bladder cancer | 44.41 | 9.53 | 17 | 366226 | 19509 | 79358636 |
Skin ulcer | 44.25 | 9.53 | 116 | 366127 | 54034 | 79324111 |
Cardio-respiratory arrest | 44.08 | 9.53 | 722 | 365521 | 107788 | 79270357 |
Needle fatigue | 43.84 | 9.53 | 35 | 366208 | 867 | 79377278 |
Myocardial infarction | 43.71 | 9.53 | 589 | 365654 | 183540 | 79194605 |
Neutropenic sepsis | 43.70 | 9.53 | 36 | 366207 | 27028 | 79351117 |
Bone marrow failure | 43.69 | 9.53 | 107 | 366136 | 51000 | 79327145 |
Intentional product misuse | 43.53 | 9.53 | 646 | 365597 | 94519 | 79283626 |
Dehydration | 43.41 | 9.53 | 1468 | 364775 | 246719 | 79131426 |
Lethargy | 43.32 | 9.53 | 567 | 365676 | 80725 | 79297420 |
Blood prolactin increased | 43.22 | 9.53 | 71 | 366172 | 3940 | 79374205 |
Acute myocardial infarction | 42.67 | 9.53 | 195 | 366048 | 76841 | 79301304 |
Amnesia | 42.49 | 9.53 | 460 | 365783 | 62597 | 79315548 |
Poverty of speech | 42.28 | 9.53 | 29 | 366214 | 565 | 79377580 |
Antipsychotic drug level decreased | 42.17 | 9.53 | 39 | 366204 | 1185 | 79376960 |
Dysphagia | 41.87 | 9.53 | 791 | 365452 | 121345 | 79256800 |
Gastrointestinal haemorrhage | 41.73 | 9.53 | 455 | 365788 | 147264 | 79230881 |
Enthesopathy | 41.68 | 9.53 | 3 | 366240 | 11605 | 79366540 |
Osmolar gap increased | 41.44 | 9.53 | 17 | 366226 | 106 | 79378039 |
Cardiac failure | 41.36 | 9.53 | 483 | 365760 | 154359 | 79223786 |
Panic attack | 41.31 | 9.53 | 220 | 366023 | 23996 | 79354149 |
Myocardial fibrosis | 41.24 | 9.53 | 45 | 366198 | 1673 | 79376472 |
Malaise | 41.07 | 9.53 | 1835 | 364408 | 488034 | 78890111 |
Respiratory acidosis | 41.05 | 9.53 | 129 | 366114 | 11071 | 79367074 |
Urinary incontinence | 41.01 | 9.53 | 325 | 365918 | 40584 | 79337561 |
Gait spastic | 40.96 | 9.53 | 38 | 366205 | 1159 | 79376986 |
Schizoaffective disorder | 40.94 | 9.53 | 50 | 366193 | 2102 | 79376043 |
Injection site swelling | 40.82 | 9.53 | 98 | 366145 | 47034 | 79331111 |
Pleurothotonus | 40.82 | 9.53 | 54 | 366189 | 2462 | 79375683 |
Myocardial depression | 40.45 | 9.53 | 27 | 366216 | 502 | 79377643 |
Red blood cell sedimentation rate abnormal | 40.35 | 9.53 | 23 | 366220 | 20940 | 79357205 |
Logorrhoea | 40.11 | 9.53 | 72 | 366171 | 4293 | 79373852 |
Intentional product use issue | 40.05 | 9.53 | 476 | 365767 | 151636 | 79226509 |
Injection site pruritus | 39.82 | 9.53 | 84 | 366159 | 42199 | 79335946 |
Basal cell carcinoma | 39.78 | 9.53 | 69 | 366174 | 37306 | 79340839 |
Haematotoxicity | 39.72 | 9.53 | 11 | 366232 | 15508 | 79362637 |
Glossodynia | 39.37 | 9.53 | 295 | 365948 | 103042 | 79275103 |
Transplant rejection | 39.36 | 9.53 | 20 | 366223 | 19417 | 79358728 |
Electroencephalogram abnormal | 39.32 | 9.53 | 81 | 366162 | 5353 | 79372792 |
Drop attacks | 39.05 | 9.53 | 35 | 366208 | 1020 | 79377125 |
Psychotic behaviour | 38.94 | 9.53 | 36 | 366207 | 1093 | 79377052 |
Narcotic bowel syndrome | 38.94 | 9.53 | 21 | 366222 | 259 | 79377886 |
Blood sodium decreased | 38.89 | 9.53 | 274 | 365969 | 32981 | 79345164 |
Hyponatraemia | 38.84 | 9.53 | 1081 | 365162 | 176767 | 79201378 |
Communication disorder | 38.27 | 9.53 | 68 | 366175 | 4022 | 79374123 |
Echolalia | 37.94 | 9.53 | 23 | 366220 | 359 | 79377786 |
Multiple organ dysfunction syndrome | 37.83 | 9.53 | 361 | 365882 | 119885 | 79258260 |
Generalised tonic-clonic seizure | 37.73 | 9.53 | 337 | 365906 | 43573 | 79334572 |
H1N1 influenza | 37.72 | 9.53 | 52 | 366191 | 2467 | 79375678 |
Osteoporosis | 37.64 | 9.53 | 125 | 366118 | 53987 | 79324158 |
Paradoxical drug reaction | 37.41 | 9.53 | 94 | 366149 | 7091 | 79371054 |
Impaired quality of life | 37.19 | 9.53 | 10 | 366233 | 14376 | 79363769 |
Aplastic anaemia | 37.17 | 9.53 | 172 | 366071 | 17733 | 79360412 |
Pathogen resistance | 37.02 | 9.53 | 10 | 366233 | 14332 | 79363813 |
Rhinitis perennial | 36.94 | 9.53 | 22 | 366221 | 332 | 79377813 |
Encephalitis autoimmune | 36.85 | 9.53 | 49 | 366194 | 2245 | 79375900 |
Drug screen positive | 36.60 | 9.53 | 84 | 366159 | 5979 | 79372166 |
Nervousness | 36.59 | 9.53 | 271 | 365972 | 33144 | 79345001 |
Osteonecrosis of jaw | 36.56 | 9.53 | 91 | 366152 | 43135 | 79335010 |
Headache | 36.41 | 9.53 | 2549 | 363694 | 651223 | 78726922 |
Anxiolytic therapy | 36.17 | 9.53 | 13 | 366230 | 53 | 79378092 |
Drug therapy enhancement | 36.17 | 9.53 | 13 | 366230 | 53 | 79378092 |
Depressed mood | 36.14 | 9.53 | 361 | 365882 | 48119 | 79330026 |
Victim of child abuse | 36.04 | 9.53 | 32 | 366211 | 921 | 79377224 |
Suicidal behaviour | 35.69 | 9.53 | 58 | 366185 | 3189 | 79374956 |
Alcohol abuse | 35.40 | 9.53 | 77 | 366166 | 5286 | 79372859 |
Pericarditis | 35.37 | 9.53 | 307 | 365936 | 103929 | 79274216 |
Sexually inappropriate behaviour | 35.04 | 9.53 | 25 | 366218 | 520 | 79377625 |
Decorticate posture | 35.02 | 9.53 | 21 | 366222 | 321 | 79377824 |
Sinusitis | 34.81 | 9.53 | 660 | 365583 | 194841 | 79183304 |
Treatment noncompliance | 34.62 | 9.53 | 380 | 365863 | 51888 | 79326257 |
Pneumocystis jirovecii pneumonia | 34.61 | 9.53 | 60 | 366183 | 32448 | 79345697 |
Obsessive-compulsive disorder | 34.55 | 9.53 | 81 | 366162 | 5846 | 79372299 |
Rhabdomyolysis | 34.35 | 9.53 | 665 | 365578 | 102466 | 79275679 |
Dyspnoea | 34.10 | 9.53 | 3432 | 362811 | 853593 | 78524552 |
Ulcer | 34.08 | 9.53 | 53 | 366190 | 29919 | 79348226 |
Inappropriate antidiuretic hormone secretion | 33.87 | 9.53 | 222 | 366021 | 26091 | 79352054 |
Mood altered | 33.83 | 9.53 | 167 | 366076 | 17680 | 79360465 |
Maternal exposure during pregnancy | 33.78 | 9.53 | 433 | 365810 | 136105 | 79242040 |
Bone erosion | 33.76 | 9.53 | 20 | 366223 | 17827 | 79360318 |
Febrile bone marrow aplasia | 33.76 | 9.53 | 9 | 366234 | 13011 | 79365134 |
Drug reaction with eosinophilia and systemic symptoms | 33.60 | 9.53 | 166 | 366077 | 64078 | 79314067 |
Myoclonus | 33.58 | 9.53 | 230 | 366013 | 27430 | 79350715 |
Psoriatic arthropathy | 33.49 | 9.53 | 215 | 366028 | 77784 | 79300361 |
Product use issue | 33.29 | 9.53 | 722 | 365521 | 209100 | 79169045 |
Victim of sexual abuse | 33.28 | 9.53 | 24 | 366219 | 508 | 79377637 |
Coronary artery disease | 33.20 | 9.53 | 171 | 366072 | 65303 | 79312842 |
Panniculitis | 33.14 | 9.53 | 8 | 366235 | 12363 | 79365782 |
Pneumonia viral | 33.13 | 9.53 | 105 | 366138 | 9053 | 79369092 |
Rhinalgia | 32.68 | 9.53 | 47 | 366196 | 2320 | 79375825 |
Blood pH decreased | 32.66 | 9.53 | 69 | 366174 | 4642 | 79373503 |
Melaena | 32.62 | 9.53 | 156 | 366087 | 60734 | 79317411 |
Injection site reaction | 32.58 | 9.53 | 135 | 366108 | 54650 | 79323495 |
Failure to thrive | 32.58 | 9.53 | 124 | 366119 | 11720 | 79366425 |
Oropharyngeal spasm | 32.55 | 9.53 | 22 | 366221 | 418 | 79377727 |
Nasopharyngitis | 32.54 | 9.53 | 902 | 365341 | 252979 | 79125166 |
Deep vein thrombosis postoperative | 32.45 | 9.53 | 116 | 366127 | 10636 | 79367509 |
Pneumonia | 32.35 | 9.53 | 2602 | 363641 | 657644 | 78720501 |
Parkinsonian gait | 32.26 | 9.53 | 30 | 366213 | 918 | 79377227 |
Psychotic symptom | 32.16 | 9.53 | 50 | 366193 | 2647 | 79375498 |
Diabetes insipidus | 32.10 | 9.53 | 73 | 366170 | 5164 | 79372981 |
Accidental exposure to product by child | 31.80 | 9.53 | 52 | 366191 | 2874 | 79375271 |
Relapsing-remitting multiple sclerosis | 31.71 | 9.53 | 37 | 366206 | 1482 | 79376663 |
Facet joint syndrome | 31.64 | 9.53 | 119 | 366124 | 11183 | 79366962 |
Altered state of consciousness | 31.55 | 9.53 | 324 | 365919 | 43498 | 79334647 |
Staring | 31.49 | 9.53 | 49 | 366194 | 2596 | 79375549 |
Propofol infusion syndrome | 31.31 | 9.53 | 42 | 366201 | 1941 | 79376204 |
Tubulointerstitial nephritis | 31.17 | 9.53 | 82 | 366161 | 38153 | 79339992 |
Patient uncooperative | 31.11 | 9.53 | 26 | 366217 | 688 | 79377457 |
Soft tissue disorder | 31.05 | 9.53 | 57 | 366186 | 3458 | 79374687 |
Hypertonia | 30.96 | 9.53 | 88 | 366155 | 7144 | 79371001 |
Mouth ulceration | 30.80 | 9.53 | 83 | 366160 | 38311 | 79339834 |
Waxy flexibility | 30.61 | 9.53 | 18 | 366225 | 265 | 79377880 |
Loss of personal independence in daily activities | 30.58 | 9.53 | 312 | 365931 | 102268 | 79275877 |
Homicidal ideation | 30.47 | 9.53 | 56 | 366187 | 3401 | 79374744 |
Obesity | 30.40 | 9.53 | 270 | 365973 | 34855 | 79343290 |
Plasma cell myeloma | 30.29 | 9.53 | 376 | 365867 | 52883 | 79325262 |
Behaviour disorder | 30.19 | 9.53 | 80 | 366163 | 6233 | 79371912 |
Wrong patient received product | 30.14 | 9.53 | 66 | 366177 | 4552 | 79373593 |
Hyperchloraemia | 29.80 | 9.53 | 31 | 366212 | 1090 | 79377055 |
Aspiration | 29.65 | 9.53 | 176 | 366067 | 19982 | 79358163 |
Hyperprolactinaemia | 29.58 | 9.53 | 66 | 366177 | 4610 | 79373535 |
Haemophagocytic lymphohistiocytosis | 29.52 | 9.53 | 34 | 366209 | 21803 | 79356342 |
Pancreatic fibrosis | 29.50 | 9.53 | 13 | 366230 | 99 | 79378046 |
Hypoglycaemia | 29.46 | 9.53 | 311 | 365932 | 101283 | 79276862 |
Immunodeficiency | 29.31 | 9.53 | 34 | 366209 | 21734 | 79356411 |
Myocardial reperfusion injury | 29.28 | 9.53 | 13 | 366230 | 101 | 79378044 |
Anaphylactic reaction | 29.15 | 9.53 | 245 | 365998 | 83498 | 79294647 |
Sleep disorder | 29.05 | 9.53 | 554 | 365689 | 85123 | 79293022 |
Drug resistance | 29.03 | 9.53 | 98 | 366145 | 42115 | 79336030 |
Hyperkalaemia | 28.96 | 9.53 | 361 | 365882 | 114037 | 79264108 |
Haematuria | 28.92 | 9.53 | 191 | 366052 | 68645 | 79309500 |
Joint injury | 28.88 | 9.53 | 63 | 366180 | 31272 | 79346873 |
Rheumatoid factor positive | 28.83 | 9.53 | 159 | 366084 | 59680 | 79318465 |
Cholestasis | 28.80 | 9.53 | 132 | 366111 | 51977 | 79326168 |
Blister | 28.77 | 9.53 | 381 | 365862 | 119095 | 79259050 |
Parosmia | 28.73 | 9.53 | 84 | 366159 | 6930 | 79371215 |
Condition aggravated | 28.66 | 9.53 | 1949 | 364294 | 499175 | 78878970 |
CSF oligoclonal band present | 28.66 | 9.53 | 20 | 366223 | 401 | 79377744 |
Faecaloma | 28.52 | 9.53 | 117 | 366126 | 11447 | 79366698 |
Self-injurious ideation | 28.44 | 9.53 | 56 | 366187 | 3582 | 79374563 |
Lip dry | 28.32 | 9.53 | 143 | 366100 | 15275 | 79362870 |
Nicotine dependence | 28.29 | 9.53 | 28 | 366215 | 927 | 79377218 |
Bradycardia | 28.21 | 9.53 | 819 | 365424 | 134738 | 79243407 |
Crying | 28.21 | 9.53 | 192 | 366051 | 22851 | 79355294 |
Device issue | 27.99 | 9.53 | 51 | 366192 | 27057 | 79351088 |
Anger | 27.98 | 9.53 | 154 | 366089 | 17008 | 79361137 |
Atelectasis | 27.94 | 9.53 | 248 | 365995 | 32009 | 79346136 |
Myelodysplastic syndrome | 27.86 | 9.53 | 61 | 366182 | 30240 | 79347905 |
Cataract | 27.82 | 9.53 | 169 | 366074 | 61951 | 79316194 |
Acute psychosis | 27.57 | 9.53 | 60 | 366183 | 4120 | 79374025 |
Cough | 27.52 | 9.53 | 1390 | 364853 | 365399 | 79012746 |
Monoparesis | 27.39 | 9.53 | 54 | 366189 | 3457 | 79374688 |
Head injury | 27.24 | 9.53 | 277 | 365966 | 37092 | 79341053 |
Emotional distress | 27.12 | 9.53 | 292 | 365951 | 39677 | 79338468 |
Bronchiectasis | 27.00 | 9.53 | 38 | 366205 | 22348 | 79355797 |
Parathyroid gland enlargement | 26.96 | 9.53 | 14 | 366229 | 159 | 79377986 |
Urinary retention | 26.91 | 9.53 | 387 | 365856 | 56243 | 79321902 |
Angina pectoris | 26.86 | 9.53 | 134 | 366109 | 51598 | 79326547 |
Kidney transplant rejection | 26.72 | 9.53 | 7 | 366236 | 10239 | 79367906 |
Alcohol interaction | 26.68 | 9.53 | 65 | 366178 | 4809 | 79373336 |
Forced expiratory volume | 26.62 | 9.53 | 12 | 366231 | 97 | 79378048 |
Colorectal cancer | 26.53 | 9.53 | 4 | 366239 | 8643 | 79369502 |
Gastric cancer | 26.46 | 9.53 | 7 | 366236 | 10172 | 79367973 |
Menstrual disorder | 26.40 | 9.53 | 58 | 366185 | 4009 | 79374136 |
Thinking abnormal | 26.27 | 9.53 | 125 | 366118 | 13036 | 79365109 |
Lower respiratory tract infection | 26.27 | 9.53 | 426 | 365817 | 128794 | 79249351 |
Poisoning deliberate | 26.18 | 9.53 | 162 | 366081 | 18666 | 79359479 |
Social avoidant behaviour | 26.14 | 9.53 | 64 | 366179 | 4750 | 79373395 |
Breast cancer female | 26.03 | 9.53 | 10 | 366233 | 11451 | 79366694 |
Child abuse | 26.03 | 9.53 | 19 | 366224 | 410 | 79377735 |
Foot deformity | 26.03 | 9.53 | 44 | 366199 | 24030 | 79354115 |
Change of bowel habit | 26.01 | 9.53 | 46 | 366197 | 2711 | 79375434 |
Balance disorder | 26 | 9.53 | 616 | 365627 | 98241 | 79279904 |
Thrombocytopenia | 25.95 | 9.53 | 976 | 365267 | 264283 | 79113862 |
Dyspnoea exertional | 25.88 | 9.53 | 265 | 365978 | 86808 | 79291337 |
Phagophobia | 25.87 | 9.53 | 10 | 366233 | 52 | 79378093 |
Confabulation | 25.66 | 9.53 | 20 | 366223 | 478 | 79377667 |
Accidental death | 25.41 | 9.53 | 59 | 366184 | 4232 | 79373913 |
Impaired driving ability | 25.27 | 9.53 | 68 | 366175 | 5347 | 79372798 |
Alcohol withdrawal syndrome | 24.99 | 9.53 | 38 | 366205 | 1973 | 79376172 |
Oedema peripheral | 24.96 | 9.53 | 927 | 365316 | 251361 | 79126784 |
Iatrogenic injury | 24.85 | 9.53 | 33 | 366210 | 1510 | 79376635 |
Drug screen false positive | 24.81 | 9.53 | 28 | 366215 | 1081 | 79377064 |
Inflammation | 24.81 | 9.53 | 293 | 365950 | 93460 | 79284685 |
PCO2 increased | 24.63 | 9.53 | 36 | 366207 | 1804 | 79376341 |
Hyperthyroidism | 24.56 | 9.53 | 40 | 366203 | 22169 | 79355976 |
Impulsive behaviour | 24.34 | 9.53 | 46 | 366197 | 2854 | 79375291 |
Device malfunction | 24.31 | 9.53 | 38 | 366205 | 21410 | 79356735 |
Acute generalised exanthematous pustulosis | 24.27 | 9.53 | 26 | 366217 | 17228 | 79360917 |
Visual acuity reduced | 24.18 | 9.53 | 63 | 366180 | 29406 | 79348739 |
Polyarthritis | 24.05 | 9.53 | 13 | 366230 | 12189 | 79365956 |
Fear | 23.89 | 9.53 | 178 | 366065 | 21808 | 79356337 |
Movement disorder | 23.83 | 9.53 | 210 | 366033 | 27049 | 79351096 |
Oral discharge | 23.74 | 9.53 | 15 | 366228 | 253 | 79377892 |
Galactorrhoea | 23.67 | 9.53 | 52 | 366191 | 3594 | 79374551 |
Mitochondrial DNA mutation | 23.64 | 9.53 | 18 | 366225 | 415 | 79377730 |
Prescribed overdose | 23.54 | 9.53 | 272 | 365971 | 37611 | 79340534 |
Macrocytosis | 23.44 | 9.53 | 45 | 366198 | 2825 | 79375320 |
Neologism | 23.43 | 9.53 | 7 | 366236 | 13 | 79378132 |
Orgasmic sensation decreased | 23.41 | 9.53 | 9 | 366234 | 46 | 79378099 |
Pulmonary tuberculosis | 23.32 | 9.53 | 4 | 366239 | 7861 | 79370284 |
Encephalopathy | 23.26 | 9.53 | 437 | 365806 | 66960 | 79311185 |
Rapid eye movements sleep abnormal | 23.18 | 9.53 | 15 | 366228 | 264 | 79377881 |
Solar urticaria | 23.11 | 9.53 | 11 | 366232 | 102 | 79378043 |
Upper respiratory tract infection | 22.96 | 9.53 | 288 | 365955 | 90880 | 79287265 |
Transplant dysfunction | 22.96 | 9.53 | 3 | 366240 | 7218 | 79370927 |
Psychiatric decompensation | 22.93 | 9.53 | 54 | 366189 | 3909 | 79374236 |
Compartment syndrome | 22.90 | 9.53 | 63 | 366180 | 5019 | 79373126 |
Morbid thoughts | 22.81 | 9.53 | 23 | 366220 | 779 | 79377366 |
Accidental overdose | 22.75 | 9.53 | 280 | 365963 | 39301 | 79338844 |
Aspergillus infection | 22.64 | 9.53 | 33 | 366210 | 19128 | 79359017 |
Fluid retention | 22.63 | 9.53 | 208 | 366035 | 69601 | 79308544 |
Device difficult to use | 22.62 | 9.53 | 17 | 366226 | 13368 | 79364777 |
Apallic syndrome | 22.62 | 9.53 | 25 | 366218 | 943 | 79377202 |
PO2 increased | 22.62 | 9.53 | 32 | 366211 | 1556 | 79376589 |
Rash pruritic | 22.54 | 9.53 | 215 | 366028 | 71414 | 79306731 |
Coeliac disease | 22.51 | 9.53 | 12 | 366231 | 11339 | 79366806 |
Epidural lipomatosis | 22.51 | 9.53 | 28 | 366215 | 1200 | 79376945 |
Renal disorder | 22.48 | 9.53 | 108 | 366135 | 41997 | 79336148 |
Gait disturbance | 22.47 | 9.53 | 1167 | 365076 | 206339 | 79171806 |
Wound | 22.31 | 9.53 | 387 | 365856 | 115792 | 79262353 |
Medication error | 22.31 | 9.53 | 441 | 365802 | 68201 | 79309944 |
Bipolar disorder | 22.29 | 9.53 | 82 | 366161 | 7625 | 79370520 |
Epstein-Barr virus infection | 22.27 | 9.53 | 20 | 366223 | 14396 | 79363749 |
Creatinine renal clearance decreased | 22.18 | 9.53 | 33 | 366210 | 18969 | 79359176 |
Soliloquy | 22.14 | 9.53 | 21 | 366222 | 659 | 79377486 |
Bronchopulmonary aspergillosis | 22.09 | 9.53 | 43 | 366200 | 22251 | 79355894 |
Restless legs syndrome | 22.02 | 9.53 | 163 | 366080 | 19929 | 79358216 |
Herpes zoster | 21.99 | 9.53 | 298 | 365945 | 92785 | 79285360 |
Hypophagia | 21.94 | 9.53 | 311 | 365932 | 45056 | 79333089 |
Oral pain | 21.90 | 9.53 | 233 | 366010 | 31565 | 79346580 |
Coma scale | 21.82 | 9.53 | 9 | 366234 | 57 | 79378088 |
Illusion | 21.78 | 9.53 | 33 | 366210 | 1708 | 79376437 |
Diarrhoea | 21.74 | 9.53 | 3634 | 362609 | 876855 | 78501290 |
Finger deformity | 21.73 | 9.53 | 4 | 366239 | 7470 | 79370675 |
Respiratory rate decreased | 21.67 | 9.53 | 63 | 366180 | 5180 | 79372965 |
Eczema | 21.61 | 9.53 | 105 | 366138 | 40713 | 79337432 |
Oesophageal carcinoma | 21.57 | 9.53 | 12 | 366231 | 11072 | 79367073 |
Disinhibition | 21.54 | 9.53 | 41 | 366202 | 2557 | 79375588 |
Testicular atrophy | 21.54 | 9.53 | 16 | 366227 | 355 | 79377790 |
Thrombosis | 21.43 | 9.53 | 265 | 365978 | 83835 | 79294310 |
Atrial fibrillation | 21.42 | 9.53 | 719 | 365524 | 197167 | 79180978 |
Tachyphrenia | 21.31 | 9.53 | 36 | 366207 | 2044 | 79376101 |
BK virus infection | 21.16 | 9.53 | 7 | 366236 | 8797 | 79369348 |
Tendonitis | 21.07 | 9.53 | 49 | 366194 | 23781 | 79354364 |
Premature ejaculation | 21.07 | 9.53 | 9 | 366234 | 63 | 79378082 |
Screaming | 21.05 | 9.53 | 52 | 366191 | 3881 | 79374264 |
Hypercapnia | 20.94 | 9.53 | 89 | 366154 | 8846 | 79369299 |
Pressure of speech | 20.92 | 9.53 | 27 | 366216 | 1201 | 79376944 |
Drug abuser | 20.89 | 9.53 | 68 | 366175 | 5945 | 79372200 |
Osteonecrosis | 20.83 | 9.53 | 73 | 366170 | 31022 | 79347123 |
Cytomegalovirus infection reactivation | 20.83 | 9.53 | 7 | 366236 | 8709 | 79369436 |
Knee arthroplasty | 20.79 | 9.53 | 115 | 366128 | 43133 | 79335012 |
Sluggishness | 20.78 | 9.53 | 72 | 366171 | 6500 | 79371645 |
Small intestinal obstruction | 20.77 | 9.53 | 204 | 366039 | 27068 | 79351077 |
Neurosensory hypoacusis | 20.69 | 9.53 | 13 | 366230 | 217 | 79377928 |
Skin exfoliation | 20.65 | 9.53 | 158 | 366085 | 54942 | 79323203 |
Unintentional medical device removal | 20.63 | 9.53 | 5 | 366238 | 7707 | 79370438 |
Joint effusion | 20.34 | 9.53 | 32 | 366211 | 17982 | 79360163 |
Vasculitis | 20.34 | 9.53 | 54 | 366189 | 25048 | 79353097 |
Wrong technique in product usage process | 20.28 | 9.53 | 229 | 366014 | 73646 | 79304499 |
Haematochezia | 20.20 | 9.53 | 282 | 365961 | 87363 | 79290782 |
Hyperosmolar state | 20.19 | 9.53 | 20 | 366223 | 663 | 79377482 |
Feeling of body temperature change | 20.13 | 9.53 | 62 | 366181 | 5264 | 79372881 |
Device adhesion issue | 20.12 | 9.53 | 4 | 366239 | 7071 | 79371074 |
Cerebral infarction | 20.07 | 9.53 | 125 | 366118 | 45551 | 79332594 |
Drug clearance decreased | 19.98 | 9.53 | 46 | 366197 | 3281 | 79374864 |
Mucormycosis | 19.89 | 9.53 | 7 | 366236 | 8462 | 79369683 |
Feelings of worthlessness | 19.82 | 9.53 | 18 | 366225 | 534 | 79377611 |
Chronic kidney disease | 19.80 | 9.53 | 201 | 366042 | 65953 | 79312192 |
Cerebral microhaemorrhage | 19.79 | 9.53 | 13 | 366230 | 235 | 79377910 |
Echopraxia | 19.76 | 9.53 | 8 | 366235 | 48 | 79378097 |
Disease recurrence | 19.75 | 9.53 | 120 | 366123 | 43989 | 79334156 |
Peripheral venous disease | 19.74 | 9.53 | 133 | 366110 | 15776 | 79362369 |
Coronary artery stenosis | 19.67 | 9.53 | 17 | 366226 | 12467 | 79365678 |
Endophthalmitis | 19.66 | 9.53 | 3 | 366240 | 6425 | 79371720 |
Skin reaction | 19.65 | 9.53 | 27 | 366216 | 16041 | 79362104 |
Hangover | 19.61 | 9.53 | 35 | 366208 | 2077 | 79376068 |
Cytomegalovirus viraemia | 19.55 | 9.53 | 18 | 366225 | 12803 | 79365342 |
Diet refusal | 19.50 | 9.53 | 22 | 366221 | 849 | 79377296 |
Priapism | 19.46 | 9.53 | 55 | 366188 | 4450 | 79373695 |
Proteinuria | 19.38 | 9.53 | 80 | 366163 | 32422 | 79345723 |
Muscle disorder | 19.35 | 9.53 | 64 | 366179 | 5643 | 79372502 |
Drug screen negative | 19.34 | 9.53 | 14 | 366229 | 298 | 79377847 |
Skin toxicity | 19.31 | 9.53 | 7 | 366236 | 8307 | 79369838 |
Colitis ulcerative | 19.20 | 9.53 | 88 | 366155 | 34654 | 79343491 |
Mitochondrial encephalomyopathy | 19.20 | 9.53 | 7 | 366236 | 30 | 79378115 |
Partial seizures | 19.20 | 9.53 | 87 | 366156 | 8891 | 79369254 |
COVID-19 pneumonia | 19.14 | 9.53 | 68 | 366175 | 28781 | 79349364 |
Neutrophil count increased | 19.14 | 9.53 | 213 | 366030 | 29183 | 79348962 |
Tuberculosis | 19.13 | 9.53 | 25 | 366218 | 15173 | 79362972 |
Discomfort | 19.12 | 9.53 | 435 | 365808 | 125182 | 79252963 |
Cognitive disorder | 19.09 | 9.53 | 438 | 365805 | 69488 | 79308657 |
Thrombotic microangiopathy | 19.05 | 9.53 | 40 | 366203 | 20129 | 79358016 |
Gallbladder disorder | 19.03 | 9.53 | 153 | 366090 | 19187 | 79358958 |
Bradypnoea | 18.87 | 9.53 | 66 | 366177 | 5986 | 79372159 |
Grandiosity | 18.87 | 9.53 | 18 | 366225 | 569 | 79377576 |
End stage renal disease | 18.82 | 9.53 | 17 | 366226 | 12203 | 79365942 |
Electrocardiogram J wave | 18.73 | 9.53 | 8 | 366235 | 56 | 79378089 |
Injection site bruising | 18.65 | 9.53 | 111 | 366132 | 40891 | 79337254 |
Bronchitis | 18.61 | 9.53 | 457 | 365786 | 130187 | 79247958 |
Injury | 18.61 | 9.53 | 477 | 365766 | 77019 | 79301126 |
Loose associations | 18.61 | 9.53 | 8 | 366235 | 57 | 79378088 |
Cerebral atrophy | 18.59 | 9.53 | 80 | 366163 | 7995 | 79370150 |
Multiple-drug resistance | 18.57 | 9.53 | 85 | 366158 | 8723 | 79369422 |
Autonomic nervous system imbalance | 18.53 | 9.53 | 55 | 366188 | 4575 | 79373570 |
Clumsiness | 18.52 | 9.53 | 43 | 366200 | 3084 | 79375061 |
Rhesus antigen positive | 18.50 | 9.53 | 10 | 366233 | 124 | 79378021 |
Micturition urgency | 18.36 | 9.53 | 110 | 366133 | 12531 | 79365614 |
Leukocytosis | 18.33 | 9.53 | 291 | 365952 | 43164 | 79334981 |
Hallucination, tactile | 18.31 | 9.53 | 18 | 366225 | 591 | 79377554 |
Hyperhidrosis | 18.27 | 9.53 | 861 | 365382 | 150631 | 79227514 |
Device use error | 18.24 | 9.53 | 5 | 366238 | 7096 | 79371049 |
Immune reconstitution inflammatory syndrome | 18.23 | 9.53 | 22 | 366221 | 13819 | 79364326 |
Coronary artery bypass | 18.16 | 9.53 | 3 | 366240 | 6059 | 79372086 |
Cannabinoid hyperemesis syndrome | 18.15 | 9.53 | 8 | 366235 | 61 | 79378084 |
Hepatocellular injury | 18.06 | 9.53 | 136 | 366107 | 47457 | 79330688 |
Attention deficit hyperactivity disorder | 17.97 | 9.53 | 44 | 366199 | 3265 | 79374880 |
Lip swelling | 17.96 | 9.53 | 112 | 366131 | 40799 | 79337346 |
Benzodiazepine drug level increased | 17.94 | 9.53 | 12 | 366231 | 224 | 79377921 |
Monocyte count decreased | 17.85 | 9.53 | 43 | 366200 | 3158 | 79374987 |
Self-medication | 17.80 | 9.53 | 58 | 366185 | 5074 | 79373071 |
Upper respiratory fungal infection | 17.73 | 9.53 | 14 | 366229 | 341 | 79377804 |
Respiratory failure | 17.71 | 9.53 | 1008 | 365235 | 179903 | 79198242 |
Metabolic encephalopathy | 17.63 | 9.53 | 86 | 366157 | 9061 | 79369084 |
Nephrolithiasis | 17.61 | 9.53 | 158 | 366085 | 53133 | 79325012 |
Dementia | 17.60 | 9.53 | 182 | 366061 | 24477 | 79353668 |
Joint destruction | 17.60 | 9.53 | 3 | 366240 | 5922 | 79372223 |
Acute coronary syndrome | 17.47 | 9.53 | 45 | 366198 | 21088 | 79357057 |
Renal ischaemia | 17.42 | 9.53 | 24 | 366219 | 1138 | 79377007 |
Blood bicarbonate decreased | 17.41 | 9.53 | 58 | 366185 | 5133 | 79373012 |
Femur fracture | 17.39 | 9.53 | 105 | 366138 | 38547 | 79339598 |
Haematuria traumatic | 17.38 | 9.53 | 11 | 366232 | 186 | 79377959 |
Infective pulmonary exacerbation of cystic fibrosis | 17.38 | 9.53 | 20 | 366223 | 12831 | 79365314 |
Respiratory distress | 17.37 | 9.53 | 370 | 365873 | 57969 | 79320176 |
Abortion spontaneous | 17.36 | 9.53 | 73 | 366170 | 29434 | 79348711 |
Protein C increased | 17.35 | 9.53 | 9 | 366234 | 102 | 79378043 |
Cerebrovascular accident | 17.33 | 9.53 | 562 | 365681 | 154730 | 79223415 |
Skin maceration | 17.31 | 9.53 | 8 | 366235 | 69 | 79378076 |
Hepatocellular carcinoma | 17.22 | 9.53 | 10 | 366233 | 9011 | 79369134 |
Rectal polyp | 17.15 | 9.53 | 29 | 366214 | 1648 | 79376497 |
Shock haemorrhagic | 17.14 | 9.53 | 42 | 366201 | 20018 | 79358127 |
Liver disorder | 17.04 | 9.53 | 232 | 366011 | 72185 | 79305960 |
Frustration tolerance decreased | 17.02 | 9.53 | 74 | 366169 | 7428 | 79370717 |
Enuresis | 17.01 | 9.53 | 42 | 366201 | 3134 | 79375011 |
Sneezing | 16.99 | 9.53 | 41 | 366202 | 19642 | 79358503 |
Gastric ulcer | 16.94 | 9.53 | 89 | 366154 | 33816 | 79344329 |
Ear infection | 16.86 | 9.53 | 91 | 366152 | 34341 | 79343804 |
Blood creatine phosphokinase | 16.78 | 9.53 | 10 | 366233 | 151 | 79377994 |
Nodule | 16.77 | 9.53 | 52 | 366191 | 22942 | 79355203 |
Therapeutic product ineffective | 16.77 | 9.53 | 31 | 366212 | 1891 | 79376254 |
Abulia | 16.71 | 9.53 | 22 | 366221 | 998 | 79377147 |
Clonus | 16.71 | 9.53 | 69 | 366174 | 6771 | 79371374 |
Breast cancer stage I | 16.69 | 9.53 | 5 | 366238 | 6695 | 79371450 |
Haemoglobin urine | 16.67 | 9.53 | 10 | 366233 | 153 | 79377992 |
Coordination abnormal | 16.52 | 9.53 | 136 | 366107 | 17176 | 79360969 |
Schizophreniform disorder | 16.50 | 9.53 | 10 | 366233 | 156 | 79377989 |
Nephropathy toxic | 16.49 | 9.53 | 44 | 366199 | 20375 | 79357770 |
Blood osmolarity increased | 16.48 | 9.53 | 18 | 366225 | 670 | 79377475 |
Hypochloraemia | 16.48 | 9.53 | 36 | 366207 | 2479 | 79375666 |
Aphasia | 16.47 | 9.53 | 304 | 365939 | 46428 | 79331717 |
Muscle mass | 16.40 | 9.53 | 15 | 366228 | 449 | 79377696 |
Glaucoma | 16.40 | 9.53 | 42 | 366201 | 19719 | 79358426 |
Tachypnoea | 16.40 | 9.53 | 222 | 366021 | 31841 | 79346304 |
Sacroiliitis | 16.38 | 9.53 | 46 | 366197 | 3708 | 79374437 |
Affect lability | 16.37 | 9.53 | 98 | 366145 | 11161 | 79366984 |
Urine abnormality | 16.36 | 9.53 | 78 | 366165 | 8141 | 79370004 |
Arthritis bacterial | 16.34 | 9.53 | 11 | 366232 | 9155 | 79368990 |
Hypernatraemia | 16.28 | 9.53 | 118 | 366125 | 14333 | 79363812 |
Posturing | 16.17 | 9.53 | 22 | 366221 | 1031 | 79377114 |
Renal failure | 16.15 | 9.53 | 756 | 365487 | 200212 | 79177933 |
Brain death | 16.08 | 9.53 | 60 | 366183 | 5617 | 79372528 |
Polyneuropathy | 15.98 | 9.53 | 57 | 366186 | 24094 | 79354051 |
Dysphoria | 15.97 | 9.53 | 53 | 366190 | 4681 | 79373464 |
Drug ineffective for unapproved indication | 15.92 | 9.53 | 327 | 365916 | 50911 | 79327234 |
Laryngeal injury | 15.88 | 9.53 | 5 | 366238 | 12 | 79378133 |
Drug-induced liver injury | 15.86 | 9.53 | 211 | 366032 | 65906 | 79312239 |
Pulmonary fibrosis | 15.83 | 9.53 | 128 | 366115 | 43984 | 79334161 |
Therapy interrupted | 15.81 | 9.53 | 82 | 366161 | 31259 | 79346886 |
Diaphragmatic rupture | 15.79 | 9.53 | 11 | 366232 | 220 | 79377925 |
Premature delivery | 15.78 | 9.53 | 55 | 366188 | 23412 | 79354733 |
Musculoskeletal stiffness | 15.78 | 9.53 | 650 | 365593 | 174358 | 79203787 |
Oculogyric crisis | 15.77 | 9.53 | 39 | 366204 | 2913 | 79375232 |
Manic symptom | 15.76 | 9.53 | 9 | 366234 | 125 | 79378020 |
Nasal congestion | 15.68 | 9.53 | 252 | 365991 | 76300 | 79301845 |
Sexual relationship change | 15.59 | 9.53 | 5 | 366238 | 13 | 79378132 |
Pulseless electrical activity | 15.59 | 9.53 | 115 | 366128 | 14045 | 79364100 |
Hepatitis | 15.59 | 9.53 | 172 | 366071 | 55555 | 79322590 |
Autoimmune disorder | 15.58 | 9.53 | 130 | 366113 | 16482 | 79361663 |
Renal cancer | 15.51 | 9.53 | 20 | 366223 | 12206 | 79365939 |
Wrong drug | 15.49 | 9.53 | 12 | 366231 | 284 | 79377861 |
Cardiac failure chronic | 15.42 | 9.53 | 17 | 366226 | 11118 | 79367027 |
Thought insertion | 15.40 | 9.53 | 6 | 366237 | 32 | 79378113 |
Pyrexia | 15.37 | 9.53 | 2814 | 363429 | 675895 | 78702250 |
Gout | 15.33 | 9.53 | 60 | 366183 | 24689 | 79353456 |
Inflammatory marker increased | 15.31 | 9.53 | 16 | 366227 | 10724 | 79367421 |
Oxygen saturation abnormal | 15.19 | 9.53 | 51 | 366192 | 4531 | 79373614 |
Somatic hallucination | 15.18 | 9.53 | 7 | 366236 | 60 | 79378085 |
Bundle branch block right | 15.14 | 9.53 | 96 | 366147 | 11155 | 79366990 |
Eye disorder | 15.00 | 9.53 | 56 | 366187 | 23356 | 79354789 |
Inappropriate affect | 14.97 | 9.53 | 26 | 366217 | 1510 | 79376635 |
Drug dose omission by device | 14.97 | 9.53 | 5 | 366238 | 6245 | 79371900 |
Myositis | 14.95 | 9.53 | 42 | 366201 | 19126 | 79359019 |
Water intoxication | 14.75 | 9.53 | 18 | 366225 | 756 | 79377389 |
Granuloma | 14.73 | 9.53 | 10 | 366233 | 8287 | 79369858 |
Rash erythematous | 14.73 | 9.53 | 182 | 366061 | 57587 | 79320558 |
Sputum purulent | 14.70 | 9.53 | 24 | 366219 | 1325 | 79376820 |
Urticaria | 14.62 | 9.53 | 698 | 365545 | 184503 | 79193642 |
Nocardiosis | 14.58 | 9.53 | 4 | 366239 | 5675 | 79372470 |
Uveitis | 14.57 | 9.53 | 35 | 366208 | 16795 | 79361350 |
Erysipelas | 14.55 | 9.53 | 17 | 366226 | 10833 | 79367312 |
Nephrotic syndrome | 14.46 | 9.53 | 18 | 366225 | 11156 | 79366989 |
Lupus-like syndrome | 14.37 | 9.53 | 26 | 366217 | 13831 | 79364314 |
Focal dyscognitive seizures | 14.33 | 9.53 | 42 | 366201 | 3470 | 79374675 |
Blood lactic acid increased | 14.32 | 9.53 | 104 | 366139 | 12640 | 79365505 |
Morose | 14.29 | 9.53 | 6 | 366237 | 40 | 79378105 |
Extensor plantar response | 14.20 | 9.53 | 28 | 366215 | 1793 | 79376352 |
Blood albumin increased | 14.17 | 9.53 | 25 | 366218 | 1470 | 79376675 |
Diabetic ketoacidosis | 14.17 | 9.53 | 95 | 366148 | 34027 | 79344118 |
Polydipsia | 14.12 | 9.53 | 64 | 366179 | 6541 | 79371604 |
Soft tissue swelling | 14.10 | 9.53 | 25 | 366218 | 1476 | 79376669 |
Libido decreased | 14.06 | 9.53 | 55 | 366188 | 5266 | 79372879 |
Negative thoughts | 14.05 | 9.53 | 24 | 366219 | 1375 | 79376770 |
Rales | 14.05 | 9.53 | 46 | 366197 | 19955 | 79358190 |
Dependence | 14.01 | 9.53 | 33 | 366210 | 2389 | 79375756 |
Dystonic tremor | 13.97 | 9.53 | 10 | 366233 | 209 | 79377936 |
Differential white blood cell count abnormal | 13.91 | 9.53 | 30 | 366213 | 2047 | 79376098 |
Platelet production decreased | 13.91 | 9.53 | 4 | 366239 | 6 | 79378139 |
Generalised anxiety disorder | 13.89 | 9.53 | 31 | 366212 | 2166 | 79375979 |
Bone density decreased | 13.88 | 9.53 | 25 | 366218 | 13322 | 79364823 |
Hypomania | 13.88 | 9.53 | 70 | 366173 | 7474 | 79370671 |
Dermatitis exfoliative generalised | 13.86 | 9.53 | 8 | 366235 | 7233 | 79370912 |
Shoshin beriberi | 13.83 | 9.53 | 7 | 366236 | 75 | 79378070 |
Pancytopenia | 13.82 | 9.53 | 621 | 365622 | 165124 | 79213021 |
Appendicitis | 13.81 | 9.53 | 49 | 366194 | 20745 | 79357400 |
Lymphocyte count decreased | 13.78 | 9.53 | 299 | 365944 | 46990 | 79331155 |
Rhinorrhoea | 13.78 | 9.53 | 256 | 365987 | 75818 | 79302327 |
Alcoholism | 13.75 | 9.53 | 43 | 366200 | 3680 | 79374465 |
Respiratory tract infection | 13.73 | 9.53 | 150 | 366093 | 48539 | 79329606 |
Autoimmune haemolytic anaemia | 13.71 | 9.53 | 11 | 366232 | 8369 | 79369776 |
Blood lactic acid decreased | 13.69 | 9.53 | 11 | 366232 | 275 | 79377870 |
Blunted affect | 13.68 | 9.53 | 14 | 366229 | 483 | 79377662 |
Alcohol use | 13.64 | 9.53 | 51 | 366192 | 4780 | 79373365 |
Hypervigilance | 13.63 | 9.53 | 14 | 366229 | 485 | 79377660 |
Brain abscess | 13.60 | 9.53 | 3 | 366240 | 4933 | 79373212 |
Dysphemia | 13.58 | 9.53 | 41 | 366202 | 3443 | 79374702 |
Injection site rash | 13.52 | 9.53 | 40 | 366203 | 17914 | 79360231 |
Nerve degeneration | 13.52 | 9.53 | 11 | 366232 | 280 | 79377865 |
Regressive behaviour | 13.45 | 9.53 | 9 | 366234 | 168 | 79377977 |
Growth hormone deficiency | 13.45 | 9.53 | 13 | 366230 | 418 | 79377727 |
Stereotypy | 13.40 | 9.53 | 19 | 366224 | 926 | 79377219 |
Anxiety disorder | 13.35 | 9.53 | 46 | 366197 | 4141 | 79374004 |
Blood creatinine increased | 13.33 | 9.53 | 579 | 365664 | 154478 | 79223667 |
Hypersexuality | 13.30 | 9.53 | 26 | 366217 | 1654 | 79376491 |
Cutaneous vasculitis | 13.29 | 9.53 | 11 | 366232 | 8241 | 79369904 |
Sputum discoloured | 13.29 | 9.53 | 53 | 366190 | 21690 | 79356455 |
Sepsis | 13.26 | 9.53 | 1061 | 365182 | 268367 | 79109778 |
Memory impairment | 13.25 | 9.53 | 634 | 365609 | 111100 | 79267045 |
Drug specific antibody present | 13.24 | 9.53 | 7 | 366236 | 6645 | 79371500 |
Surgery | 13.22 | 9.53 | 92 | 366151 | 32674 | 79345471 |
Metabolic alkalosis | 13.18 | 9.53 | 48 | 366195 | 4441 | 79373704 |
Prostate tenderness | 13.16 | 9.53 | 3 | 366240 | 0 | 79378145 |
Aortic valve stenosis | 13.10 | 9.53 | 4 | 366239 | 5290 | 79372855 |
Post procedural infection | 13.07 | 9.53 | 20 | 366223 | 11364 | 79366781 |
Adrenal insufficiency | 13.02 | 9.53 | 77 | 366166 | 28410 | 79349735 |
Carbohydrate antigen 125 increased | 12.90 | 9.53 | 30 | 366213 | 2154 | 79375991 |
Delusional perception | 12.88 | 9.53 | 12 | 366231 | 368 | 79377777 |
Blood gases abnormal | 12.87 | 9.53 | 21 | 366222 | 1159 | 79376986 |
Paralysis | 12.83 | 9.53 | 104 | 366139 | 13073 | 79365072 |
Hepatitis B reactivation | 12.80 | 9.53 | 6 | 366237 | 6102 | 79372043 |
Fluid replacement | 12.78 | 9.53 | 14 | 366229 | 523 | 79377622 |
Dysmetropsia | 12.73 | 9.53 | 7 | 366236 | 90 | 79378055 |
Pulmonary toxicity | 12.71 | 9.53 | 25 | 366218 | 12889 | 79365256 |
Hyporesponsive to stimuli | 12.68 | 9.53 | 29 | 366214 | 2059 | 79376086 |
Graft versus host disease in skin | 12.67 | 9.53 | 6 | 366237 | 6067 | 79372078 |
Injection site warmth | 12.65 | 9.53 | 31 | 366212 | 14776 | 79363369 |
Fibromyalgia | 12.64 | 9.53 | 386 | 365857 | 63954 | 79314191 |
Malignant catatonia | 12.62 | 9.53 | 13 | 366230 | 452 | 79377693 |
Toxic skin eruption | 12.60 | 9.53 | 56 | 366187 | 22237 | 79355908 |
Coronary arterial stent insertion | 12.57 | 9.53 | 6 | 366237 | 6038 | 79372107 |
Self esteem decreased | 12.54 | 9.53 | 19 | 366224 | 983 | 79377162 |
On and off phenomenon | 12.51 | 9.53 | 38 | 366205 | 3202 | 79374943 |
Dermatitis exfoliative | 12.45 | 9.53 | 19 | 366224 | 10810 | 79367335 |
Perseveration | 12.44 | 9.53 | 12 | 366231 | 385 | 79377760 |
Chronic obstructive pulmonary disease | 12.42 | 9.53 | 495 | 365748 | 84924 | 79293221 |
Panic disorder | 12.41 | 9.53 | 36 | 366207 | 2956 | 79375189 |
Influenza | 12.41 | 9.53 | 478 | 365765 | 129128 | 79249017 |
Drug use disorder | 12.38 | 9.53 | 75 | 366168 | 8576 | 79369569 |
Vasoconstriction | 12.36 | 9.53 | 16 | 366227 | 714 | 79377431 |
Vulvar basal cell carcinoma | 12.35 | 9.53 | 5 | 366238 | 30 | 79378115 |
Myalgia | 12.32 | 9.53 | 712 | 365531 | 184929 | 79193216 |
Anaemia of malignant disease | 12.31 | 9.53 | 17 | 366226 | 808 | 79377337 |
Immunosuppressant drug level increased | 12.26 | 9.53 | 14 | 366229 | 9013 | 79369132 |
Foreign body aspiration | 12.26 | 9.53 | 11 | 366232 | 321 | 79377824 |
Blood test abnormal | 12.25 | 9.53 | 41 | 366202 | 17669 | 79360476 |
Hypotension | 12.23 | 9.53 | 2248 | 363995 | 438069 | 78940076 |
Sickle cell anaemia with crisis | 12.23 | 9.53 | 11 | 366232 | 7911 | 79370234 |
Vulvovaginal pruritus | 12.22 | 9.53 | 33 | 366210 | 2600 | 79375545 |
Delirium tremens | 12.22 | 9.53 | 16 | 366227 | 722 | 79377423 |
Induced abortion failed | 12.22 | 9.53 | 9 | 366234 | 197 | 79377948 |
Maximal voluntary ventilation abnormal | 12.21 | 9.53 | 5 | 366238 | 31 | 79378114 |
Oropharyngeal swelling | 12.18 | 9.53 | 22 | 366221 | 1318 | 79376827 |
Pseudophaeochromocytoma | 12.15 | 9.53 | 7 | 366236 | 99 | 79378046 |
Panic reaction | 12.15 | 9.53 | 48 | 366195 | 4617 | 79373528 |
Middle insomnia | 12.14 | 9.53 | 120 | 366123 | 15949 | 79362196 |
Areflexia | 12.11 | 9.53 | 54 | 366189 | 5480 | 79372665 |
Hallucination, olfactory | 12.09 | 9.53 | 13 | 366230 | 475 | 79377670 |
Suspected suicide attempt | 12.09 | 9.53 | 11 | 366232 | 327 | 79377818 |
Electroconvulsive therapy | 12.09 | 9.53 | 7 | 366236 | 100 | 79378045 |
Myopathy | 12.02 | 9.53 | 51 | 366192 | 20512 | 79357633 |
Impaired work ability | 12.01 | 9.53 | 48 | 366195 | 19633 | 79358512 |
Fear of injection | 11.99 | 9.53 | 10 | 366233 | 7464 | 79370681 |
Device dislocation | 11.97 | 9.53 | 70 | 366173 | 25900 | 79352245 |
Diabetes mellitus inadequate control | 11.95 | 9.53 | 64 | 366179 | 24200 | 79353945 |
Polydipsia psychogenic | 11.91 | 9.53 | 9 | 366234 | 205 | 79377940 |
Laryngitis | 11.89 | 9.53 | 36 | 366207 | 16003 | 79362142 |
Apathy | 11.88 | 9.53 | 101 | 366142 | 12876 | 79365269 |
Dry mouth | 11.86 | 9.53 | 506 | 365737 | 87513 | 79290632 |
Erectile dysfunction | 11.81 | 9.53 | 111 | 366132 | 14553 | 79363592 |
Semen volume decreased | 11.80 | 9.53 | 6 | 366237 | 65 | 79378080 |
Post-injection delirium sedation syndrome | 11.80 | 9.53 | 14 | 366229 | 571 | 79377574 |
Cerebral haemorrhage | 11.76 | 9.53 | 190 | 366053 | 57483 | 79320662 |
Myocarditis | 11.75 | 9.53 | 152 | 366091 | 21581 | 79356564 |
Glycosylated haemoglobin increased | 11.74 | 9.53 | 47 | 366196 | 19213 | 79358932 |
Intraocular pressure increased | 11.73 | 9.53 | 15 | 366228 | 9190 | 79368955 |
Hypotonia | 11.69 | 9.53 | 100 | 366143 | 12770 | 79365375 |
Varicella zoster virus infection | 11.65 | 9.53 | 3 | 366240 | 4438 | 79373707 |
Product storage error | 11.62 | 9.53 | 37 | 366206 | 16189 | 79361956 |
Neonatal hypoxia | 11.60 | 9.53 | 4 | 366239 | 14 | 79378131 |
Hypertonic bladder | 11.57 | 9.53 | 44 | 366199 | 4157 | 79373988 |
Hepatotoxicity | 11.56 | 9.53 | 166 | 366077 | 51186 | 79326959 |
Acute graft versus host disease | 11.54 | 9.53 | 18 | 366225 | 10149 | 79367996 |
Nasal polyps | 11.52 | 9.53 | 10 | 366233 | 7317 | 79370828 |
Neck mass | 11.50 | 9.53 | 3 | 366240 | 4401 | 79373744 |
Substance-induced psychotic disorder | 11.48 | 9.53 | 38 | 366205 | 3351 | 79374794 |
Sensitivity to weather change | 11.46 | 9.53 | 12 | 366231 | 8035 | 79370110 |
Foot operation | 11.46 | 9.53 | 6 | 366237 | 5727 | 79372418 |
Rabbit syndrome | 11.42 | 9.53 | 11 | 366232 | 352 | 79377793 |
Blood uric acid increased | 11.39 | 9.53 | 28 | 366215 | 13332 | 79364813 |
Foot fracture | 11.37 | 9.53 | 57 | 366186 | 21924 | 79356221 |
Increased appetite | 11.37 | 9.53 | 94 | 366149 | 11884 | 79366261 |
Injection site haemorrhage | 11.37 | 9.53 | 78 | 366165 | 27792 | 79350353 |
Labelled drug-drug interaction issue | 11.35 | 9.53 | 22 | 366221 | 1391 | 79376754 |
Klebsiella bacteraemia | 11.34 | 9.53 | 35 | 366208 | 2975 | 79375170 |
Thymus disorder | 11.29 | 9.53 | 10 | 366233 | 287 | 79377858 |
Porphyria acute | 11.25 | 9.53 | 23 | 366220 | 1512 | 79376633 |
Hypertensive crisis | 11.25 | 9.53 | 53 | 366190 | 20717 | 79357428 |
Exposure via breast milk | 11.23 | 9.53 | 18 | 366225 | 978 | 79377167 |
Drug tolerance decreased | 11.23 | 9.53 | 27 | 366216 | 12951 | 79365194 |
Natural killer cell count | 11.19 | 9.53 | 4 | 366239 | 16 | 79378129 |
Antidepressant drug level increased | 11.13 | 9.53 | 12 | 366231 | 440 | 79377705 |
pH urine increased | 11.13 | 9.53 | 12 | 366231 | 440 | 79377705 |
Anion gap increased | 11.11 | 9.53 | 40 | 366203 | 3680 | 79374465 |
Adverse event | 11.10 | 9.53 | 202 | 366041 | 60012 | 79318133 |
Psychopathic personality | 11.10 | 9.53 | 3 | 366240 | 3 | 79378142 |
Thought withdrawal | 11.10 | 9.53 | 3 | 366240 | 3 | 79378142 |
Antidepressant drug level below therapeutic | 11.10 | 9.53 | 3 | 366240 | 3 | 79378142 |
Purpura | 11.07 | 9.53 | 49 | 366194 | 19478 | 79358667 |
Selective mutism | 11.06 | 9.53 | 6 | 366237 | 75 | 79378070 |
Atypical femur fracture | 11.02 | 9.53 | 5 | 366238 | 5184 | 79372961 |
Vomiting | 11.02 | 9.53 | 3320 | 362923 | 662508 | 78715637 |
Amegakaryocytic thrombocytopenia | 11.00 | 9.53 | 4 | 366239 | 17 | 79378128 |
Respiratory alkalosis | 10.94 | 9.53 | 44 | 366199 | 4267 | 79373878 |
Angina unstable | 10.94 | 9.53 | 39 | 366204 | 16488 | 79361657 |
Weight decreased | 10.88 | 9.53 | 1447 | 364796 | 353751 | 79024394 |
Septic shock | 10.87 | 9.53 | 457 | 365786 | 122344 | 79255801 |
Hyponatriuria | 10.82 | 9.53 | 4 | 366239 | 18 | 79378127 |
Hypoprolactinaemia | 10.82 | 9.53 | 4 | 366239 | 18 | 79378127 |
Peritonitis bacterial | 10.80 | 9.53 | 17 | 366226 | 9550 | 79368595 |
Pneumoconiosis | 10.74 | 9.53 | 9 | 366234 | 239 | 79377906 |
Forced expiratory volume decreased | 10.74 | 9.53 | 12 | 366231 | 7802 | 79370343 |
Psychiatric symptom | 10.72 | 9.53 | 62 | 366181 | 6973 | 79371172 |
Toxicologic test abnormal | 10.71 | 9.53 | 21 | 366222 | 1339 | 79376806 |
Cardiac murmur | 10.70 | 9.53 | 37 | 366206 | 15787 | 79362358 |
Inappropriate schedule of product administration | 10.67 | 9.53 | 503 | 365740 | 133125 | 79245020 |
Hyperuricaemia | 10.64 | 9.53 | 24 | 366219 | 11775 | 79366370 |
Psychomotor skills impaired | 10.64 | 9.53 | 50 | 366193 | 5187 | 79372958 |
Affective ambivalence | 10.64 | 9.53 | 4 | 366239 | 19 | 79378126 |
Abortion spontaneous complete | 10.64 | 9.53 | 3 | 366240 | 4 | 79378141 |
Skin disorder | 10.63 | 9.53 | 102 | 366141 | 33841 | 79344304 |
Staphylococcal infection | 10.61 | 9.53 | 196 | 366047 | 58099 | 79320046 |
Antipsychotic drug level above therapeutic | 10.61 | 9.53 | 27 | 366216 | 2053 | 79376092 |
Tangentiality | 10.60 | 9.53 | 8 | 366235 | 182 | 79377963 |
Arthropod bite | 10.60 | 9.53 | 14 | 366229 | 8457 | 79369688 |
Death of relative | 10.56 | 9.53 | 9 | 366234 | 245 | 79377900 |
Hepatic failure | 10.47 | 9.53 | 208 | 366035 | 61004 | 79317141 |
C-reactive protein | 10.46 | 9.53 | 48 | 366195 | 4931 | 79373214 |
Vulvovaginal burning sensation | 10.43 | 9.53 | 23 | 366220 | 1594 | 79376551 |
Ventricular fibrillation | 10.40 | 9.53 | 95 | 366148 | 31831 | 79346314 |
Hypogammaglobulinaemia | 10.39 | 9.53 | 28 | 366215 | 12923 | 79365222 |
Progressive multifocal leukoencephalopathy | 10.33 | 9.53 | 54 | 366189 | 20546 | 79357599 |
Pulmonary arterial hypertension | 10.32 | 9.53 | 82 | 366161 | 28284 | 79349861 |
Depressive delusion | 10.32 | 9.53 | 4 | 366239 | 21 | 79378124 |
Back pain | 10.32 | 9.53 | 1231 | 365012 | 302949 | 79075196 |
Refusal of treatment by relative | 10.32 | 9.53 | 15 | 366228 | 748 | 79377397 |
Flight of ideas | 10.31 | 9.53 | 16 | 366227 | 846 | 79377299 |
Incorrect dose administered by device | 10.30 | 9.53 | 5 | 366238 | 4984 | 79373161 |
Accidental exposure to product | 10.29 | 9.53 | 93 | 366150 | 31229 | 79346916 |
Mean cell haemoglobin increased | 10.29 | 9.53 | 43 | 366200 | 4242 | 79373903 |
Eye pruritus | 10.27 | 9.53 | 54 | 366189 | 20516 | 79357629 |
Pneumonia cytomegaloviral | 10.23 | 9.53 | 5 | 366238 | 4964 | 79373181 |
Feeling guilty | 10.22 | 9.53 | 16 | 366227 | 852 | 79377293 |
Ultrasound abdomen abnormal | 10.22 | 9.53 | 7 | 366236 | 136 | 79378009 |
Sarcoidosis | 10.20 | 9.53 | 14 | 366229 | 8321 | 79369824 |
Human herpesvirus 6 infection | 10.18 | 9.53 | 6 | 366237 | 5364 | 79372781 |
Diverticulitis | 10.16 | 9.53 | 149 | 366094 | 45787 | 79332358 |
Stent placement | 10.13 | 9.53 | 9 | 366234 | 6511 | 79371634 |
Underdose | 10.11 | 9.53 | 211 | 366032 | 32940 | 79345205 |
Acute respiratory failure | 10.09 | 9.53 | 351 | 365892 | 59190 | 79318955 |
Hyponatraemic syndrome | 10.06 | 9.53 | 15 | 366228 | 765 | 79377380 |
Food craving | 10.05 | 9.53 | 23 | 366220 | 1634 | 79376511 |
Ocular hyperaemia | 10.05 | 9.53 | 82 | 366161 | 28124 | 79350021 |
Delusional disorder, unspecified type | 10.03 | 9.53 | 15 | 366228 | 767 | 79377378 |
Immunosuppression | 10.03 | 9.53 | 28 | 366215 | 12775 | 79365370 |
Purple glove syndrome | 10.02 | 9.53 | 9 | 366234 | 263 | 79377882 |
Heart rate increased | 10.01 | 9.53 | 663 | 365580 | 120061 | 79258084 |
Hypocalcaemia | 10.00 | 9.53 | 165 | 366078 | 49759 | 79328386 |
Hypertension | 9.94 | 9.53 | 1350 | 364893 | 329642 | 79048503 |
Retinal detachment | 9.91 | 9.53 | 17 | 366226 | 9230 | 79368915 |
Gerstmann's syndrome | 9.90 | 9.53 | 3 | 366240 | 6 | 79378139 |
Pleocytosis | 9.89 | 9.53 | 21 | 366222 | 1418 | 79376727 |
Morbihan disease | 9.88 | 9.53 | 4 | 366239 | 24 | 79378121 |
Duodenal ulcer haemorrhage | 9.85 | 9.53 | 11 | 366232 | 7152 | 79370993 |
Phonophobia | 9.84 | 9.53 | 12 | 366231 | 504 | 79377641 |
Libido disorder | 9.80 | 9.53 | 9 | 366234 | 271 | 79377874 |
False positive investigation result | 9.78 | 9.53 | 18 | 366225 | 1094 | 79377051 |
Hyperventilation | 9.78 | 9.53 | 66 | 366177 | 7833 | 79370312 |
Atrial tachycardia | 9.76 | 9.53 | 11 | 366232 | 7122 | 79371023 |
Type I hypersensitivity | 9.72 | 9.53 | 4 | 366239 | 4394 | 79373751 |
Subarachnoid haemorrhage | 9.72 | 9.53 | 69 | 366174 | 24396 | 79353749 |
Ureteric obstruction | 9.70 | 9.53 | 31 | 366212 | 2685 | 79375460 |
Sexual dysfunction | 9.69 | 9.53 | 65 | 366178 | 7698 | 79370447 |
Deja vu | 9.69 | 9.53 | 5 | 366238 | 56 | 79378089 |
Bacterial test positive | 9.68 | 9.53 | 63 | 366180 | 7386 | 79370759 |
Radiation pneumonitis | 9.68 | 9.53 | 3 | 366240 | 3930 | 79374215 |
Lymphoproliferative disorder | 9.66 | 9.53 | 7 | 366236 | 5608 | 79372537 |
Slow response to stimuli | 9.63 | 9.53 | 24 | 366219 | 1801 | 79376344 |
Cellulitis | 9.63 | 9.53 | 406 | 365837 | 108654 | 79269491 |
Skin cancer | 9.62 | 9.53 | 36 | 366207 | 15004 | 79363141 |
Squamous cell carcinoma of the oral cavity | 9.61 | 9.53 | 12 | 366231 | 516 | 79377629 |
Sleep-related eating disorder | 9.60 | 9.53 | 14 | 366229 | 700 | 79377445 |
Obsessive rumination | 9.58 | 9.53 | 3 | 366240 | 7 | 79378138 |
Antidepressant drug level decreased | 9.58 | 9.53 | 3 | 366240 | 7 | 79378138 |
Torsade de pointes | 9.58 | 9.53 | 133 | 366110 | 19179 | 79358966 |
Acute stress disorder | 9.58 | 9.53 | 11 | 366232 | 433 | 79377712 |
Normal newborn | 9.57 | 9.53 | 11 | 366232 | 7061 | 79371084 |
Adenovirus infection | 9.54 | 9.53 | 15 | 366228 | 8432 | 79369713 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hypotonia neonatal | 41.37 | 25.35 | 34 | 466 | 742 | 88550 |
Neonatal asphyxia | 30.48 | 25.35 | 14 | 486 | 97 | 89195 |
Nasal congestion | 26.02 | 25.35 | 9 | 491 | 25 | 89267 |
Source | Code | Description |
---|---|---|
ATC | N05BA06 | NERVOUS SYSTEM PSYCHOLEPTICS ANXIOLYTICS Benzodiazepine derivatives |
ATC | N05BA56 | NERVOUS SYSTEM PSYCHOLEPTICS ANXIOLYTICS Benzodiazepine derivatives |
FDA CS | M0002356 | Benzodiazepines |
MeSH PA | D014151 | Anti-Anxiety Agents |
MeSH PA | D000927 | Anticonvulsants |
MeSH PA | D000932 | Antiemetics |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D018682 | GABA Agents |
MeSH PA | D018757 | GABA Modulators |
MeSH PA | D005765 | Gastrointestinal Agents |
MeSH PA | D006993 | Hypnotics and Sedatives |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D014149 | Tranquilizing Agents |
FDA EPC | N0000175694 | Benzodiazepine |
CHEBI has role | CHEBI:35717 | hypnotics |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Myoclonic seizure | indication | 37356005 | |
Atonic seizure | indication | 42365007 | |
Anxiety | indication | 48694002 | |
Absence seizure | indication | 79631006 | |
Lennox-Gastaut syndrome | indication | 230418006 | |
Status epilepticus | indication | 230456007 | DOID:1824 |
Panic disorder | indication | 371631005 | DOID:594 |
Sedation as Adjunct to Anesthesia | indication | ||
Induce Anterograde Amnesia | indication | ||
Delirium | off-label use | 2776000 | |
Alcohol withdrawal delirium | off-label use | 8635005 | |
General anesthesia | off-label use | 50697003 | |
Seizure disorder | off-label use | 128613002 | |
Alcohol withdrawal syndrome | off-label use | 191480000 | |
Insomnia | off-label use | 193462001 | |
Spasticity | off-label use | 221360009 | |
Chemotherapy-induced nausea and vomiting | off-label use | 236084000 | |
Akathisia | off-label use | 285145004 | |
Local anesthesia | off-label use | 386761002 | |
Cocaine-Associated Acute Ischemic Heart Disease | off-label use | ||
Manic Bipolar Disorder Adjunct Treatment | off-label use | ||
Sedation in Intubated Patients | off-label use | ||
Suicidal thoughts | contraindication | 6471006 | |
Hepatic encephalopathy | contraindication | 13920009 | DOID:13413 |
Alcohol intoxication | contraindication | 25702006 | |
Depressive disorder | contraindication | 35489007 | |
Acute nephropathy | contraindication | 58574008 | |
Hepatic failure | contraindication | 59927004 | |
Substance abuse | contraindication | 66214007 | |
Sleep apnea | contraindication | 73430006 | DOID:0050847 |
Decreased respiratory function | contraindication | 80954004 | |
Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Hypoalbuminemia | contraindication | 119247004 | |
Liver function tests abnormal | contraindication | 166603001 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Syncope | contraindication | 271594007 | |
Pregnancy, function | contraindication | 289908002 | |
Severe chronic obstructive pulmonary disease | contraindication | 313299006 | |
At risk for aspiration | contraindication | 371736008 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Breastfeeding (mother) | contraindication | 413712001 | |
Chronic lung disease | contraindication | 413839001 | |
Central nervous system depression | contraindication | 418072004 | |
Porphyria | contraindication | 418470004 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.09 | acidic |
pKa2 | 11.41 | acidic |
pKa3 | 0.63 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
1.5MG | LOREEV XR | ALMATICA | N214826 | Feb. 16, 2022 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8999393 | Jan. 8, 2034 | ONCE DAILY TREATMENT OF ANXIETY DISORDER IN ADULTS |
1MG | LOREEV XR | ALMATICA | N214826 | Aug. 27, 2021 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8999393 | Jan. 8, 2034 | ONCE DAILY TREATMENT OF ANXIETY DISORDER IN ADULTS |
2MG | LOREEV XR | ALMATICA | N214826 | Aug. 27, 2021 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8999393 | Jan. 8, 2034 | ONCE DAILY TREATMENT OF ANXIETY DISORDER IN ADULTS |
3MG | LOREEV XR | ALMATICA | N214826 | Aug. 27, 2021 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8999393 | Jan. 8, 2034 | ONCE DAILY TREATMENT OF ANXIETY DISORDER IN ADULTS |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
GABA-A receptor alpha-1/beta-3/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | IC50 | 8.46 | WOMBAT-PK | CHEMBL | |||
Fatty acid-binding protein, liver | Unclassified | Ki | 4.89 | CHEMBL |
ID | Source |
---|---|
4017848 | VUID |
N0000146205 | NUI |
D00365 | KEGG_DRUG |
4017848 | VANDF |
C0024002 | UMLSCUI |
CHEBI:6539 | CHEBI |
CHEMBL249262 | ChEMBL_ID |
CHEMBL580 | ChEMBL_ID |
CHEMBL399057 | ChEMBL_ID |
DB00186 | DRUGBANK_ID |
D008140 | MESH_DESCRIPTOR_UI |
3958 | PUBCHEM_CID |
5884 | IUPHAR_LIGAND_ID |
2809 | INN_ID |
O26FZP769L | UNII |
202479 | RXNORM |
2104 | MMSL |
3795 | MMSL |
4995 | MMSL |
d00149 | MMSL |
001460 | NDDF |
19225000 | SNOMEDCT_US |
387106007 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-3532 | SOLUTION, CONCENTRATE | 2 mg | ORAL | ANDA | 19 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-3532 | SOLUTION, CONCENTRATE | 2 mg | ORAL | ANDA | 19 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3425 | TABLET | 0.50 mg | ORAL | ANDA | 21 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3425 | TABLET | 0.50 mg | ORAL | ANDA | 21 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3425 | TABLET | 0.50 mg | ORAL | ANDA | 21 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3426 | TABLET | 1 mg | ORAL | ANDA | 21 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3426 | TABLET | 1 mg | ORAL | ANDA | 21 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3426 | TABLET | 1 mg | ORAL | ANDA | 21 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3427 | TABLET | 2 mg | ORAL | ANDA | 21 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3427 | TABLET | 2 mg | ORAL | ANDA | 21 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3427 | TABLET | 2 mg | ORAL | ANDA | 21 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0770 | LIQUID | 2 mg | ORAL | ANDA | 21 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0770 | LIQUID | 2 mg | ORAL | ANDA | 21 sections |
Ativan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-0063 | TABLET | 0.50 mg | ORAL | NDA | 20 sections |
Ativan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-0063 | TABLET | 0.50 mg | ORAL | NDA | 20 sections |
Ativan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-0064 | TABLET | 1 mg | ORAL | NDA | 20 sections |
Ativan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-0064 | TABLET | 1 mg | ORAL | NDA | 20 sections |
Ativan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-0065 | TABLET | 2 mg | ORAL | NDA | 20 sections |
Ativan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-0065 | TABLET | 2 mg | ORAL | NDA | 20 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1539 | INJECTION, SOLUTION | 4 mg | INTRAMUSCULAR | ANDA | 34 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1539 | INJECTION, SOLUTION | 4 mg | INTRAMUSCULAR | ANDA | 34 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1539 | INJECTION, SOLUTION | 4 mg | INTRAMUSCULAR | ANDA | 34 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1985 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | ANDA | 34 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1985 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | ANDA | 34 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1985 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | ANDA | 34 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-6778 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | ANDA | 33 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-6778 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | ANDA | 33 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-6778 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | ANDA | 33 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-6778 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | ANDA | 33 sections |
Lorazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-6778 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | ANDA | 33 sections |