lorazepam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
diazepam derivatives 1606 846-49-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ativan
  • Wy 4036
  • Wy-4036
  • lorazepam
A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.
  • Molecular weight: 321.16
  • Formula: C15H10Cl2N2O2
  • CLOGP: 2.37
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 61.69
  • ALOGS: -4.26
  • ROTB: 1
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2.50 mg O
2.50 mg P
2.50 mg SL

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.08 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.44 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 93 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.09 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 17 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 2.461 Moderate 0.77
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.689 Moderate 0.77
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 72.277 10^-6 cm/s Moderate 0.77
dh-clint Dog hepatocyte intrinsic clearance 14.421 uL/min/10^6 cells Moderate 0.77
dppb Dog plasma protein binding (% unbound) 6.210 % Moderate 0.77
fcs-ppb Fetal calf serum protein binding (% unbound) 13.740 % Moderate 0.77
herg hERG pIC50 4.492 pIC50 Moderate 0.77
hh-clint Human hepatocyte intrinsic clearance 1.932 uL/min/10^6 cells Moderate 0.77
hlm-clint Human liver microsomal intrinsic clearance 3.266 uL/min/mg protein Moderate 0.77
hppb Human plasma protein binding (% unbound) 7.010 % Moderate 0.77
kinase-safety-class ACVR2B,EIF2AK3,GRK2,PDK1,PDK2,PDK4 6
kinase-selectivity-class ACVR2B,AXL,EIF2AK3,GRK2,PDK4,TTK 6
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 1.253 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 3.741 Moderate 0.77
mh-clint Mouse hepatocyte intrinsic clearance 19.409 Moderate 0.77
mppb Mouse plasma protein binding (% unbound) 6.400 Moderate 0.77
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 8.570 Moderate 0.77
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 11.140 % Moderate 0.77
rat-kpuu-brain Rat brain Kpuu 0.385 % High 1
rh-clint Rat hepatocyte intrinsic clearance 18.281 uL/min/10^6 cells Moderate 0.77
rh-fuinc Rat hepatocyte fraction unbound in incubation 66.920 % Moderate 0.77
rppb Rat plasma protein binding (% unbound) 5.210 % Moderate 0.77
solubility-dd Solubility at pH 7.4 in DMSO 324.340 uM Moderate 0.77

Approvals:

DateAgencyCompanyOrphan
Sept. 30, 1977 FDA VALEANT INTL

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sopor 2292.48 9.28 1430 421123 23214 90182680
Drug abuse 1462.89 9.28 1861 420692 80486 90125408
Completed suicide 832.76 9.28 1987 420566 143071 90062823
Suicide attempt 700.95 9.28 1260 421293 74139 90131755
Neuroleptic malignant syndrome 537.24 9.28 493 422060 14603 90191291
Intentional overdose 523.89 9.28 1272 421281 92562 90113332
Intentional self-injury 501.78 9.28 651 421902 28683 90177211
Somnolence 456.74 9.28 2059 420494 207025 89998869
Bradyphrenia 397.44 9.28 310 422243 7302 90198592
Agitation 388.90 9.28 923 421630 66175 90139719
Coma 362.84 9.28 944 421609 71688 90134206
Drug ineffective 359.32 9.28 4437 418116 1379861 88826033
Delirium 328.84 9.28 1153 421400 103206 90102688
Toxicity to various agents 308.62 9.28 2348 420205 285498 89920396
Catatonia 299.76 9.28 239 422314 5817 90200077
Overdose 291.93 9.28 1481 421072 156228 90049666
Serotonin syndrome 289.96 9.28 583 421970 37304 90168590
Suicidal ideation 265.42 9.28 853 421700 73002 90132892
Drug withdrawal syndrome 250.37 9.28 467 422086 28256 90177638
Contraindicated product administered 248.43 9.28 720 421833 319419 89886475
Pain 215.34 9.28 3311 419242 993030 89212864
Drug intolerance 214.48 9.28 1217 421336 446374 89759520
Anxiety 199.69 9.28 2266 420287 307506 89898388
Depressed level of consciousness 194.76 9.28 763 421790 72021 90133873
Poisoning 193.54 9.28 293 422260 14924 90190970
Febrile neutropenia 193.31 9.28 1333 421220 157016 90048878
Extrapyramidal disorder 189.31 9.28 301 422252 16002 90189892
Pneumonia aspiration 189.14 9.28 517 422036 40423 90165471
Drug interaction 188.07 9.28 2044 420509 274409 89931485
Tardive dyskinesia 178.27 9.28 237 422316 10693 90195201
Akathisia 174.42 9.28 237 422316 10922 90194972
Disorientation 169.96 9.28 522 422031 43592 90162302
Psychotic disorder 168.50 9.28 418 422135 30812 90175082
Mania 168.47 9.28 264 422289 13860 90192034
Respiratory depression 167.86 9.28 278 422275 15297 90190597
Dissociation 166.17 9.28 180 422373 6535 90199359
Myelosuppression 165.09 9.28 26 422527 53565 90152329
Restlessness 162.94 9.28 449 422104 35271 90170623
Rash 162.17 9.28 2674 419879 793426 89412468
Dystonia 159.95 9.28 284 422269 16535 90189359
Confusional state 159.14 9.28 2607 419946 383598 89822296
Mydriasis 157.84 9.28 265 422288 14747 90191147
Therapeutic product effect decreased 157.72 9.28 711 421842 276860 89929034
Treatment failure 147.82 9.28 822 421731 303106 89902788
Drug dependence 146.24 9.28 381 422172 28946 90176948
COVID-19 143.44 9.28 363 422190 168480 90037414
Sedation 141.25 9.28 520 422033 47651 90158243
Bradykinesia 140.78 9.28 166 422387 6622 90199272
Off label use 138.85 9.28 3998 418555 1098254 89107640
Respiratory arrest 135.69 9.28 402 422151 32909 90172985
Tachycardia 135.44 9.28 1224 421329 156449 90049445
Hypersensitivity 125.91 9.28 1434 421119 453243 89752651
Arthralgia 125.08 9.28 2723 419830 775799 89430095
Injection site reaction 122.73 9.28 149 422404 91931 90113963
Parkinsonism 121.72 9.28 228 422325 13837 90192057
Muscle rigidity 121.41 9.28 230 422323 14079 90191815
Aggression 118.46 9.28 332 422221 26336 90179558
Speech disorder 118.01 9.28 473 422080 45112 90160782
Substance abuse 116.78 9.28 135 422418 5271 90200623
Abnormal behaviour 115.94 9.28 297 422256 22331 90183563
Psychomotor hyperactivity 115.02 9.28 211 422342 12602 90193292
Injection site pain 114.93 9.28 419 422134 173280 90032614
Dyskinesia 113.59 9.28 402 422151 36132 90169762
Therapeutic product effect incomplete 112.91 9.28 492 422061 193404 90012490
Tremor 110.83 9.28 1147 421406 152026 90053868
Delusion 108.31 9.28 215 422338 13625 90192269
Coeliac disease 107.14 9.28 37 422516 44573 90161321
Device expulsion 107.05 9.28 29 422524 40857 90165037
Product use issue 105.37 9.28 1006 421547 328913 89876981
Electrocardiogram QT prolonged 104.94 9.28 637 421916 71819 90134075
Mental status changes 101.91 9.28 446 422107 44233 90161661
Erythema 100.83 9.28 640 421913 228606 89977288
Psychomotor retardation 100.79 9.28 118 422435 4671 90201223
Slow speech 99.35 9.28 78 422475 1855 90204039
Seizure 99.32 9.28 1119 421434 151510 90054384
Alopecia 97.89 9.28 1671 420882 493400 89712494
Sinus tachycardia 97.62 9.28 324 422229 28189 90177705
Product dose omission issue 96.75 9.28 881 421672 290806 89915088
Hallucination, auditory 96.05 9.28 223 422330 15752 90190142
Onychomycosis 95.10 9.28 28 422525 37348 90168546
Joint swelling 94.34 9.28 1715 420838 501585 89704309
Injection site erythema 93.08 9.28 200 422353 98302 90107592
Salivary hypersecretion 90.97 9.28 157 422396 8935 90196959
Finger deformity 90.65 9.28 21 422532 32876 90173018
Systemic lupus erythematosus 88.16 9.28 1173 421380 360723 89845171
Mutism 87.95 9.28 70 422483 1699 90204195
Cogwheel rigidity 87.43 9.28 75 422478 2027 90203867
Drooling 85.83 9.28 106 422447 4440 90201454
Withdrawal syndrome 84.41 9.28 264 422289 22260 90183634
Gastric pH decreased 83.63 9.28 54 422499 932 90204962
Deep vein thrombosis postoperative 83.36 9.28 591 421962 70218 90135676
Myocardial depression 83.29 9.28 46 422507 587 90205307
Derealisation 83.04 9.28 63 422490 1422 90204472
Cardiac arrest 81.28 9.28 797 421756 104138 90101756
Hypothermia 80.39 9.28 205 422348 15370 90190524
Arthropathy 80.05 9.28 1213 421340 365029 89840865
Electrocardiogram QRS complex prolonged 78.97 9.28 131 422422 7217 90198677
Myoclonus 77.76 9.28 231 422322 18937 90186957
Dysarthria 76.38 9.28 475 422078 54007 90151887
Rheumatoid nodule 74.36 9.28 5 422548 20161 90185733
Mental disorder 74.00 9.28 323 422230 31995 90173899
Depression 72.50 9.28 1875 420678 298726 89907168
Status epilepticus 72.38 9.28 223 422330 18651 90187243
Onychomadesis 71.90 9.28 65 422488 45933 90159961
Unresponsive to stimuli 71.86 9.28 360 422193 37761 90168133
Autoimmune disorder 71.17 9.28 606 421947 76138 90129756
Upper respiratory tract infection 70.84 9.28 332 422221 127986 90077908
Macular degeneration 70.42 9.28 45 422508 37925 90167969
Interstitial lung disease 69.83 9.28 158 422395 76247 90129647
Coma scale abnormal 69.67 9.28 107 422446 5519 90200375
Hyponatraemia 69.14 9.28 938 421615 132600 90073294
Incontinence 68.48 9.28 176 422377 13259 90192635
Soft tissue disorder 68.40 9.28 92 422461 4198 90201696
Paranoia 66.73 9.28 170 422383 12738 90193156
Swelling 66.43 9.28 1468 421085 417590 89788304
Hallucination 65.52 9.28 529 422024 65430 90140464
Hepatitis 64.88 9.28 146 422407 70593 90135301
Cardio-respiratory arrest 64.15 9.28 509 422044 62631 90143263
Hallucination, visual 64.13 9.28 245 422308 22847 90183047
Osmolar gap increased 63.83 9.28 26 422527 156 90205738
Alcohol interaction 63.80 9.28 58 422495 1696 90204198
Lower limb fracture 63.56 9.28 641 421912 84372 90121522
Pneumonia viral 63.05 9.28 132 422421 8691 90197203
Adverse reaction 62.65 9.28 30 422523 29682 90176212
Liver function test increased 61.32 9.28 197 422356 84658 90121236
Loss of consciousness 61.12 9.28 956 421597 139282 90066612
Cytomegalovirus infection 60.62 9.28 24 422529 26578 90179316
Blood lactic acid decreased 60.58 9.28 33 422520 409 90205485
Psoriasis 60.17 9.28 422 422131 147332 90058562
Abdominal discomfort 60.08 9.28 1730 420823 475598 89730296
Infusion related reaction 59.65 9.28 1483 421070 415297 89790597
Depersonalisation/derealisation disorder 59.43 9.28 54 422499 1578 90204316
Drug hypersensitivity 59.18 9.28 1677 420876 461932 89743962
Injection site pruritus 59.00 9.28 100 422453 53734 90152160
Headache 58.90 9.28 3357 419196 859389 89346505
Computerised tomogram thorax abnormal 58.88 9.28 60 422493 2027 90203867
Lip dry 58.51 9.28 724 421829 100231 90105663
Cough 58.03 9.28 1294 421259 367668 89838226
Hallucinations, mixed 58.02 9.28 101 422452 5788 90200106
Brain injury 57.92 9.28 118 422435 7620 90198274
Hypokinesia 57.92 9.28 183 422370 15514 90190380
Injection site swelling 57.78 9.28 120 422433 59719 90146175
Vitamin B1 decreased 57.14 9.28 34 422519 504 90205390
Schizophrenia 56.99 9.28 176 422377 14738 90191156
Drug eruption 56.58 9.28 49 422504 35358 90170536
Computerised tomogram thorax 55.29 9.28 33 422520 492 90205402
Multiple-drug resistance 55.17 9.28 116 422437 7660 90198234
X-ray abnormal 55.14 9.28 382 422171 45042 90160852
Narcotic bowel syndrome 55 9.28 22 422531 125 90205769
Disorganised speech 54.65 9.28 55 422498 1830 90204064
Feeling of despair 54.61 9.28 71 422482 3133 90202761
Amnesia 54.06 9.28 757 421796 107748 90098146
Anaphylactic shock 53.96 9.28 41 422512 31576 90174318
Immunodeficiency 53.44 9.28 74 422479 43160 90162734
Persecutory delusion 52.99 9.28 70 422483 3138 90202756
Skin necrosis 52.67 9.28 8 422545 16933 90188961
PO2 increased 52.45 9.28 39 422514 853 90205041
Cardiac output increased 52.04 9.28 32 422521 505 90205389
Glossodynia 51.89 9.28 1124 421429 320655 89885239
H1N1 influenza 51.71 9.28 55 422498 1955 90203939
Hypertonia 51.55 9.28 89 422464 5066 90200828
Adjustment disorder with depressed mood 50.97 9.28 445 422108 56308 90149586
Cataract 50.96 9.28 169 422384 71923 90133971
Pruritus 50.78 9.28 2037 420516 539488 89666406
Maternal exposure during pregnancy 50.74 9.28 1284 421269 358779 89847115
Emotional disorder 50.08 9.28 169 422384 14828 90191066
Product label confusion 49.84 9.28 22 422531 22828 90183066
Hyperammonaemic encephalopathy 49.46 9.28 62 422491 2637 90203257
Hypoxia 48.99 9.28 535 422018 71864 90134030
Nicotine dependence 48.92 9.28 40 422513 1010 90204884
Loss of personal independence in daily activities 48.67 9.28 403 422150 135702 90070192
Night sweats 48.09 9.28 856 421697 127910 90077984
Dehydration 48.05 9.28 1217 421336 193230 90012664
Alcohol abuse 47.71 9.28 53 422500 1980 90203914
Skin exfoliation 47.46 9.28 160 422393 67753 90138141
Grip strength 47.31 9.28 119 422434 8846 90197048
Decreased appetite 46.95 9.28 2176 420377 374364 89831530
Patient uncooperative 46.86 9.28 24 422529 260 90205634
Basal cell carcinoma 46.67 9.28 52 422501 33337 90172557
Bronchiectasis 46.39 9.28 23 422530 22307 90183587
Head titubation 46.26 9.28 42 422511 1226 90204668
Bezoar 45.69 9.28 60 422493 2674 90203220
Blood parathyroid hormone decreased 45.13 9.28 3 422550 12213 90193681
Mouth ulceration 44.97 9.28 73 422480 39901 90165993
Synovitis 44.83 9.28 1182 421371 328570 89877324
Hyperreflexia 44.57 9.28 97 422456 6560 90199334
Red blood cell sedimentation rate abnormal 44.46 9.28 29 422524 24175 90181719
Lupus vulgaris 44.00 9.28 360 422193 44699 90161195
Blood cholesterol increased 43.75 9.28 1275 421278 206737 89999157
Road traffic accident 43.64 9.28 725 421828 106901 90098993
Rheumatoid arthritis 43.40 9.28 1323 421230 361291 89844603
Peripheral venous disease 43.23 9.28 589 421964 83332 90122562
Subcutaneous drug absorption impaired 42.92 9.28 150 422403 13395 90192499
Respiratory rate decreased 42.79 9.28 71 422482 3912 90201982
Psychiatric decompensation 42.78 9.28 49 422504 1894 90204000
Musculoskeletal pain 42.36 9.28 1072 421481 170179 90035715
Abortion spontaneous 42.27 9.28 121 422432 53935 90151959
Poisoning deliberate 41.81 9.28 170 422383 16316 90189578
Inappropriate schedule of product administration 41.74 9.28 472 422081 149461 90056433
Major depression 41.72 9.28 122 422431 9913 90195981
Diabetes insipidus 41.06 9.28 62 422491 3150 90202744
Apnoea 40.63 9.28 116 422437 9298 90196596
Encephalitis autoimmune 40.49 9.28 49 422504 2009 90203885
Stupor 40.32 9.28 83 422470 5399 90200495
Panic attack 40.22 9.28 235 422318 26130 90179764
Crying 40.05 9.28 230 422323 25415 90180479
Device difficult to use 39.63 9.28 16 422537 17509 90188385
Female genital tract fistula 39.30 9.28 17 422536 17851 90188043
Liver injury 38.51 9.28 1055 421498 169512 90036382
Porphyria acute 38.40 9.28 176 422377 17799 90188095
Sputum purulent 38.38 9.28 39 422514 1313 90204581
Fibromyalgia 38.23 9.28 1245 421308 205024 90000870
Mental impairment 38.19 9.28 167 422386 16553 90189341
Lethargy 37.96 9.28 456 422097 62683 90143211
Obesity 37.85 9.28 697 421856 104810 90101084
Ulcer haemorrhage 37.84 9.28 231 422322 26090 90179804
Victim of sexual abuse 37.80 9.28 29 422524 666 90205228
Exposure during pregnancy 37.49 9.28 836 421717 237574 89968320
Newborn persistent pulmonary hypertension 37.42 9.28 21 422532 277 90205617
Rash erythematous 37.38 9.28 166 422387 64938 90140956
Respiratory failure 37.30 9.28 767 421786 117651 90088243
Mood swings 37.27 9.28 193 422360 20509 90185385
Hand deformity 37.26 9.28 1074 421479 295288 89910606
Pemphigus 36.83 9.28 1202 421351 325662 89880232
Apraxia 36.81 9.28 49 422504 2213 90203681
Urinary retention 36.56 9.28 301 422252 37443 90168451
Screaming 36.53 9.28 64 422489 3686 90202208
Renal impairment 36.41 9.28 315 422238 105106 90100788
Feeling of body temperature change 36.34 9.28 81 422472 5568 90200326
Proctitis 36.05 9.28 13 422540 15246 90190648
Wrong patient received product 36.05 9.28 61 422492 3416 90202478
Blood prolactin increased 35.34 9.28 62 422491 3575 90202319
Propofol infusion syndrome 35.08 9.28 37 422516 1302 90204592
Change of bowel habit 34.94 9.28 48 422505 2235 90203659
Vaginal discharge 34.83 9.28 24 422529 19440 90186454
Joint injury 34.59 9.28 62 422491 32602 90173292
Decorticate posture 34.56 9.28 21 422532 324 90205570
Pneumocystis jirovecii pneumonia 34.44 9.28 30 422523 21586 90184308
Gangrene 33.96 9.28 9 422544 12867 90193027
Hypophagia 33.96 9.28 285 422268 35652 90170242
Somatic symptom disorder 33.88 9.28 59 422494 3382 90202512
Skin haemorrhage 33.67 9.28 30 422523 21350 90184544
Angioedema 33.40 9.28 172 422381 64704 90141190
Premature delivery 33.15 9.28 83 422470 38679 90167215
Panniculitis 33.02 9.28 13 422540 14445 90191449
Breast cancer female 33.00 9.28 14 422539 14872 90191022
Secondary immunodeficiency 32.99 9.28 45 422508 2081 90203813
Electroencephalogram abnormal 32.50 9.28 64 422489 4032 90201862
C-reactive protein 32.48 9.28 254 422299 31113 90174781
Hepatic enzyme increased 32.47 9.28 1363 421190 359373 89846521
Back injury 32.46 9.28 110 422443 46512 90159382
Polydipsia 32.24 9.28 65 422488 4166 90201728
Chest pain 32.19 9.28 1810 420743 317835 89888059
Food allergy 32.10 9.28 43 422510 25435 90180459
Drug-induced liver injury 32.03 9.28 268 422285 90050 90115844
Vitamin B1 increased 32.01 9.28 16 422537 164 90205730
Psychomotor skills impaired 31.94 9.28 52 422501 2820 90203074
Femur fracture 31.90 9.28 109 422444 45973 90159921
Skin ulcer 31.66 9.28 123 422430 49952 90155942
Pneumonia 31.50 9.28 2554 419999 635505 89570389
Dislocation of vertebra 31.40 9.28 399 422154 55569 90150325
Parosmia 31.39 9.28 88 422465 6981 90198913
Withdrawal catatonia 31.11 9.28 16 422537 175 90205719
Pain in extremity 31.00 9.28 1751 420802 448778 89757116
Haematotoxicity 30.79 9.28 10 422543 12525 90193369
Blood pH decreased 30.77 9.28 48 422505 2510 90203384
Sneezing 30.47 9.28 58 422495 29811 90176083
Device issue 30.44 9.28 57 422496 29480 90176414
Behaviour disorder 30.42 9.28 67 422486 4568 90201326
Hepatic function abnormal 30.37 9.28 112 422441 46176 90159718
Insomnia 30.29 9.28 1871 420682 331603 89874291
Respiratory acidosis 30.27 9.28 95 422458 8024 90197870
Antidepressant discontinuation syndrome 30.15 9.28 15 422538 152 90205742
Miosis 30.03 9.28 105 422448 9379 90196515
Cardiac failure 29.96 9.28 346 422207 109150 90096744
Asthenia 29.91 9.28 2883 419670 530868 89675026
Injection site bruising 29.65 9.28 134 422419 52173 90153721
Ataxia 29.62 9.28 164 422389 17878 90188016
Atelectasis 29.46 9.28 205 422348 24204 90181690
CSF oligoclonal band present 29.43 9.28 21 422532 430 90205464
Infection 29.34 9.28 1384 421169 360710 89845184
Skin reaction 29.25 9.28 26 422527 18527 90187367
Therapy interrupted 29.23 9.28 127 422426 49981 90155913
Impaired quality of life 29.22 9.28 39 422514 23105 90182789
Gait disturbance 29.20 9.28 1490 421063 259006 89946888
Haemophagocytic lymphohistiocytosis 29.11 9.28 18 422535 15441 90190453
Neutropenic sepsis 29.08 9.28 25 422528 18105 90187789
Clonus 28.97 9.28 75 422478 5675 90200219
Bone density decreased 28.96 9.28 23 422530 17322 90188572
Compartment syndrome 28.76 9.28 50 422503 2862 90203032
Aspiration 28.73 9.28 147 422406 15546 90190348
Mean cell haemoglobin increased 28.58 9.28 59 422494 3846 90202048
Communication disorder 28.33 9.28 53 422500 3213 90202681
Toxic epidermal necrolysis 28.33 9.28 69 422484 32459 90173435
Blood osmolarity increased 28.31 9.28 19 422534 351 90205543
Suicidal behaviour 28.31 9.28 49 422504 2795 90203099
Anaemia 28.28 9.28 1350 421203 351452 89854442
Renal ischaemia 28.19 9.28 24 422529 642 90205252
Altered state of consciousness 28.18 9.28 247 422306 31285 90174609
Injury 28.00 9.28 1156 421397 196193 90009701
Nightmare 27.73 9.28 185 422368 21540 90184354
Pancreatic fibrosis 27.68 9.28 12 422541 86 90205808
Blood creatine phosphokinase increased 27.61 9.28 261 422292 33762 90172132
Coma scale 27.25 9.28 10 422543 43 90205851
Small intestinal obstruction 27.22 9.28 181 422372 21053 90184841
Schizophreniform disorder 26.99 9.28 12 422541 92 90205802
Rash vesicular 26.99 9.28 161 422392 18036 90187858
Creatinine renal clearance decreased 26.89 9.28 29 422524 18870 90187024
Disease recurrence 26.79 9.28 88 422465 37565 90168329
Eczema 26.75 9.28 141 422412 52729 90153165
Accidental exposure to product by child 26.66 9.28 32 422521 1301 90204593
General symptom 26.58 9.28 137 422416 14531 90191363
Hyperprolactinaemia 26.49 9.28 70 422483 5363 90200531
Hypotonia neonatal 26.45 9.28 33 422520 1397 90204497
Bipolar disorder 26.34 9.28 97 422456 8888 90197006
Therapy non-responder 26.33 9.28 829 421724 135875 90070019
Myocardial reperfusion injury 26.20 9.28 13 422540 131 90205763
Alcohol use 26.13 9.28 36 422517 1681 90204213
Obsessive-compulsive disorder 26.12 9.28 62 422491 4442 90201452
Muscle disorder 26.11 9.28 70 422483 5409 90200485
Feeling jittery 26.09 9.28 141 422412 15230 90190664
Ductus arteriosus premature closure 25.97 9.28 19 422534 405 90205489
Hyperchloraemia 25.91 9.28 26 422527 862 90205032
Homicide 25.90 9.28 17 422536 302 90205592
Phagophobia 25.88 9.28 10 422543 51 90205843
C-reactive protein increased 25.74 9.28 646 421907 180743 90025151
Acute generalised exanthematous pustulosis 25.74 9.28 16 422537 13687 90192207
Joint range of motion decreased 25.71 9.28 821 421732 134822 90071072
Oral pain 25.67 9.28 249 422304 32434 90173460
Cerebral salt-wasting syndrome 25.53 9.28 15 422538 217 90205677
Aplastic anaemia 25.50 9.28 126 422427 13143 90192751
Drug dose omission by device 25.42 9.28 8 422545 10223 90195671
PCO2 increased 25.41 9.28 31 422522 1282 90204612
Solar urticaria 25.35 9.28 11 422542 79 90205815
Disinhibition 25.33 9.28 28 422525 1040 90204854
Haematochezia 25.33 9.28 210 422343 70703 90135191
Bronchitis 25.25 9.28 532 422021 152395 90053499
Antipsychotic drug level increased 25.23 9.28 55 422498 3724 90202170
Unintended pregnancy 25.19 9.28 3 422550 7634 90198260
Malaise 25.01 9.28 2372 420181 583614 89622280
Anaphylactic reaction 24.96 9.28 274 422279 87250 90118644
Influenza 24.94 9.28 478 422075 138786 90067108
Torsade de pointes 24.92 9.28 138 422415 15044 90190850
Protein C increased 24.83 9.28 10 422543 58 90205836
Muscle spasticity 24.82 9.28 83 422470 35239 90170655
Tenosynovitis 24.72 9.28 19 422534 14548 90191346
Mitochondrial DNA mutation 24.67 9.28 19 422534 439 90205455
Logorrhoea 24.59 9.28 45 422508 2682 90203212
Rhinorrhoea 24.58 9.28 278 422275 88038 90117856
Alcohol poisoning 24.58 9.28 37 422516 1875 90204019
Nasal polyps 24.49 9.28 10 422543 10870 90195024
Respiratory tract infection 24.40 9.28 168 422385 58910 90146984
Accidental exposure to product 24.33 9.28 108 422445 42258 90163636
Oedema 23.96 9.28 1153 421400 199142 90006752
Acute kidney injury 23.92 9.28 1235 421318 319152 89886742
Neonatal asphyxia 23.91 9.28 17 422536 346 90205548
Blood bicarbonate decreased 23.86 9.28 48 422505 3071 90202823
Homicidal ideation 23.67 9.28 35 422518 1745 90204149
Neonatal seizure 23.62 9.28 21 422532 596 90205298
Angina pectoris 23.61 9.28 98 422455 39062 90166832
Radiculopathy 23.55 9.28 31 422522 18474 90187420
Febrile bone marrow aplasia 23.52 9.28 8 422545 9730 90196164
Bradycardia 23.49 9.28 534 422019 83313 90122581
Product dose omission in error 23.48 9.28 37 422516 20466 90185428
Tachypnoea 23.43 9.28 175 422378 21134 90184760
Dry mouth 23.40 9.28 1066 421487 182993 90022901
Alcoholism 23.37 9.28 35 422518 1765 90204129
Pulseless electrical activity 23.37 9.28 93 422460 8839 90197055
Therapeutic product ineffective 23.26 9.28 41 422512 2373 90203521
Neurosensory hypoacusis 23.21 9.28 14 422539 213 90205681
Dyspnoea 23.16 9.28 3681 418872 877274 89328620
Generalised anxiety disorder 23.11 9.28 44 422509 2703 90203191
Menstrual disorder 23.05 9.28 72 422481 6066 90199828
Accidental overdose 22.99 9.28 217 422336 28056 90177838
Suspected suicide 22.96 9.28 97 422456 9471 90196423
Device malfunction 22.95 9.28 39 422514 20938 90184956
Respiratory alkalosis 22.81 9.28 50 422503 3398 90202496
Device dislocation 22.80 9.28 73 422480 31409 90174485
Lung disorder 22.66 9.28 884 421669 148999 90056895
Thrombocytopenia 22.44 9.28 772 421781 207953 89997941
Vasoconstriction 22.38 9.28 24 422529 861 90205033
Restless legs syndrome 22.19 9.28 180 422373 22290 90183604
Sarcoidosis 22.16 9.28 11 422542 10662 90195232
Therapeutic response decreased 22.11 9.28 290 422263 89439 90116455
Injection site rash 22.07 9.28 50 422503 24123 90181771
Ulcer 21.94 9.28 79 422474 32803 90173091
Acute psychosis 21.93 9.28 46 422507 3032 90202862
Encephalopathy 21.92 9.28 321 422232 46123 90159771
Cerebral microhaemorrhage 21.92 9.28 14 422539 237 90205657
Morbid thoughts 21.86 9.28 22 422531 732 90205162
Extensor plantar response 21.84 9.28 30 422523 1397 90204497
Emotional distress 21.70 9.28 264 422289 36398 90169496
Fear 21.49 9.28 142 422411 16480 90189414
Antidepressant drug level above therapeutic 21.44 9.28 18 422535 472 90205422
Arterial occlusive disease 21.42 9.28 16 422537 12430 90193464
Psychotic symptom 21.33 9.28 38 422515 2218 90203676
Migraine 21.32 9.28 1089 421464 189303 90016591
Therapy cessation 21.30 9.28 92 422461 36269 90169625
Drug abuser 21.30 9.28 42 422511 2648 90203246
Refusal of treatment by patient 21.26 9.28 67 422486 5671 90200223
Device adhesion issue 21.17 9.28 3 422550 6688 90199206
Therapeutic response shortened 21.16 9.28 47 422506 22832 90183062
Urinary incontinence 21.15 9.28 268 422285 37298 90168596
Polyarthritis 21.12 9.28 33 422520 18317 90187577
Staring 21.02 9.28 32 422521 1638 90204256
Blood sodium decreased 21.01 9.28 209 422344 27404 90178490
Generalised tonic-clonic seizure 20.95 9.28 252 422301 34651 90171243
Victim of crime 20.92 9.28 23 422530 849 90205045
Surgery 20.92 9.28 123 422430 44764 90161130
Areflexia 20.88 9.28 50 422503 3603 90202291
Rapid eye movements sleep abnormal 20.87 9.28 11 422542 127 90205767
Brain death 20.83 9.28 53 422500 3968 90201926
Rapid eye movement sleep behaviour disorder 20.80 9.28 16 422537 369 90205525
Pustular psoriasis 20.75 9.28 153 422400 18403 90187491
Anticholinergic syndrome 20.73 9.28 42 422511 2701 90203193
Bulimia nervosa 20.69 9.28 18 422535 496 90205398
Waxy flexibility 20.65 9.28 11 422542 130 90205764
Hypotension 20.37 9.28 1772 420781 323625 89882269
Breast cancer stage II 20.29 9.28 253 422300 35081 90170813
Sinus disorder 20.28 9.28 87 422466 34360 90171534
Gastrointestinal injury 20.23 9.28 22 422531 802 90205092
Hypoglycaemia 20.18 9.28 218 422335 69630 90136264
Abdominal pain upper 20.12 9.28 1807 420746 330867 89875027
Mood altered 20.11 9.28 143 422410 17001 90188893
Wound 20.01 9.28 1182 421371 301798 89904096
Inflammatory marker increased 19.89 9.28 9 422544 9205 90196689
Urine abnormality 19.79 9.28 80 422473 7657 90198237
Macrocytosis 19.74 9.28 42 422511 2796 90203098
Drop attacks 19.67 9.28 20 422533 674 90205220
Plasma cell myeloma 19.59 9.28 283 422270 40545 90165349
Chronic sinusitis 19.56 9.28 52 422501 23750 90182144
Neck pain 19.54 9.28 394 422159 113569 90092325
Affective disorder 19.48 9.28 80 422473 7713 90198181
Thrombotic microangiopathy 19.40 9.28 27 422526 15716 90190178
Intentional product use issue 19.39 9.28 820 421733 216072 89989822
White blood cell count increased 19.39 9.28 430 422123 66811 90139083
Arthritis 19.37 9.28 613 421940 166702 90039192
Disturbance in attention 19.33 9.28 318 422235 46791 90159103
Paralysis 19.29 9.28 105 422448 11373 90194521
Granulocytopenia 19.27 9.28 70 422483 6371 90199523
Eye pruritus 19.19 9.28 70 422483 28957 90176937
Type 2 diabetes mellitus 19.12 9.28 1144 421409 202100 90003794
Foot operation 19.11 9.28 9 422544 8992 90196902
Apallic syndrome 19.11 9.28 21 422532 775 90205119
Vasculitis 19.09 9.28 49 422504 22644 90183250
Back disorder 19.02 9.28 193 422360 25438 90180456
Treatment noncompliance 18.99 9.28 343 422210 51384 90154510
Hyperlactacidaemia 18.87 9.28 52 422501 4084 90201810
Rhabdomyolysis 18.86 9.28 340 422213 50916 90154978
Dry skin 18.76 9.28 293 422260 87780 90118114
Dermatitis atopic 18.75 9.28 52 422501 23420 90182474
Accidental death 18.73 9.28 34 422519 2014 90203880
Hypoxic-ischaemic encephalopathy 18.69 9.28 56 422497 4612 90201282
Galactorrhoea 18.66 9.28 56 422497 4616 90201278
Anion gap increased 18.66 9.28 36 422517 2234 90203660
Device breakage 18.42 9.28 23 422530 14021 90191873
Dyspnoea exertional 18.41 9.28 232 422321 72056 90133838
Unintentional medical device removal 18.38 9.28 5 422548 7025 90198869
Product storage error 18.37 9.28 42 422511 20199 90185695
Rhesus antigen positive 18.35 9.28 10 422543 124 90205770
Osteonecrosis of jaw 18.30 9.28 107 422446 38996 90166898
Hyperthyroidism 18.29 9.28 36 422517 18274 90187620
Back pain 18.25 9.28 1253 421300 315922 89889972
Cholinergic rebound syndrome 18.25 9.28 6 422547 17 90205877
Blood gases abnormal 18.24 9.28 22 422531 899 90204995
Persistent left superior vena cava 18.23 9.28 7 422546 35 90205859
Head injury 18.20 9.28 224 422329 30964 90174930
Frustration tolerance decreased 18.14 9.28 79 422474 7817 90198077
Brain oedema 18.12 9.28 141 422412 17244 90188650
Glaucoma 18.10 9.28 44 422509 20711 90185183
Inappropriate antidiuretic hormone secretion 18.06 9.28 154 422399 19351 90186543
Liver disorder 18.03 9.28 714 421839 120555 90085339
Eye injury 17.97 9.28 100 422453 10920 90194974
Rectal polyp 17.95 9.28 24 422529 1089 90204805
Oropharyngeal swelling 17.92 9.28 22 422531 916 90204978
Myocardial fibrosis 17.90 9.28 22 422531 917 90204977
Overlap syndrome 17.75 9.28 83 422470 8465 90197429
Haemoglobin urine 17.68 9.28 10 422543 134 90205760
Hypersexuality 17.67 9.28 18 422535 608 90205286
Rhinitis allergic 17.65 9.28 32 422521 16753 90189141
Wound infection 17.63 9.28 634 421919 105768 90100126
Impaired work ability 17.63 9.28 40 422513 19286 90186608
Device use error 17.32 9.28 6 422547 7215 90198679
Respiratory distress 17.15 9.28 266 422287 38680 90167214
Injection site warmth 17.01 9.28 35 422518 17480 90188414
Diverticulitis 16.97 9.28 132 422421 45055 90160839
On and off phenomenon 16.96 9.28 37 422516 2506 90203388
Muscle injury 16.93 9.28 996 421557 175658 90030236
Neutrophil count increased 16.87 9.28 151 422402 19239 90186655
Polyneuropathy 16.86 9.28 41 422512 19300 90186594
Peripheral swelling 16.79 9.28 1678 420875 411428 89794466
Oxygen saturation abnormal 16.75 9.28 51 422502 4237 90201657
Hypocholesterolaemia 16.75 9.28 67 422486 6382 90199512
Pleocytosis 16.66 9.28 22 422531 986 90204908
Neonatal respiratory failure 16.64 9.28 13 422540 307 90205587
Nodule 16.58 9.28 66 422487 26620 90179274
Cardiac malposition 16.53 9.28 7 422546 47 90205847
Psychotic behaviour 16.52 9.28 18 422535 658 90205236
Pulmonary fibrosis 16.47 9.28 635 421918 106868 90099026
Dysphemia 16.46 9.28 41 422512 3029 90202865
Erysipelas 16.42 9.28 11 422542 9041 90196853
Bursitis 16.41 9.28 761 421792 130893 90075001
Transient aphasia 16.40 9.28 7 422546 48 90205846
Cardiac failure congestive 16.39 9.28 343 422210 98351 90107543
Tremor neonatal 16.36 9.28 10 422543 156 90205738
Pancreatitis 16.35 9.28 434 422119 69392 90136502
Sacroiliitis 16.32 9.28 50 422503 4169 90201725
Enthesopathy 16.30 9.28 12 422541 9392 90196502
Streptococcal sepsis 16.29 9.28 45 422508 3539 90202355
Respiratory tract congestion 16.28 9.28 69 422484 27341 90178553
Failure to thrive 16.25 9.28 80 422473 8331 90197563
Hypochloraemia 16.20 9.28 37 422516 2585 90203309
Tubulointerstitial nephritis 16.18 9.28 62 422491 25281 90180613
Echolalia 16.18 9.28 13 422540 320 90205574
Adrenal insufficiency 16.16 9.28 78 422475 29843 90176051
Aphasia 16.11 9.28 285 422268 42527 90163367
Drug resistance 16.09 9.28 80 422473 30369 90175525
Depressed mood 16.04 9.28 326 422227 49896 90155998
Bradypnoea 16.00 9.28 53 422500 4605 90201289
Pleurothotonus 15.99 9.28 25 422528 1310 90204584
Renal disorder 15.96 9.28 107 422446 37752 90168142
Nasal congestion 15.96 9.28 283 422270 83131 90122763
Memory impairment 15.96 9.28 1096 421457 196148 90009746
Drug use disorder 15.87 9.28 79 422474 8264 90197630
Proctalgia 15.86 9.28 78 422475 8120 90197774
Anger 15.84 9.28 114 422439 13606 90192288
Adjustment disorder 15.83 9.28 13 422540 9629 90196265
Tracheal atresia 15.79 9.28 6 422547 29 90205865
Nephrogenic diabetes insipidus 15.77 9.28 21 422532 949 90204945
Patent ductus arteriosus 15.71 9.28 52 422501 4517 90201377
Eye disorder 15.62 9.28 70 422483 27320 90178574
Gallbladder disorder 15.61 9.28 151 422402 19652 90186242
Metabolic alkalosis 15.58 9.28 44 422509 3505 90202389
Cardiac murmur 15.53 9.28 39 422514 18155 90187739
Joint effusion 15.50 9.28 44 422509 19666 90186228
Cytomegalovirus viraemia 15.48 9.28 8 422545 7578 90198316
Contusion 15.40 9.28 1366 421187 249850 89956044
Leukocytosis 15.34 9.28 216 422337 30774 90175120
Platelet production decreased 15.27 9.28 4 422549 3 90205891
Uveitis 15.26 9.28 32 422521 15871 90190023
Laryngeal injury 15.26 9.28 5 422548 14 90205880
Muscle tension dysphonia 15.23 9.28 12 422541 287 90205607
Hypernatraemia 15.19 9.28 85 422468 9302 90196592
Cannabinoid hyperemesis syndrome 15.18 9.28 7 422546 59 90205835
Anomalous pulmonary venous connection 15.18 9.28 7 422546 59 90205835
Gastrointestinal haemorrhage 15.18 9.28 313 422240 89935 90115959
Tendonitis 15.17 9.28 50 422503 21322 90184572
Paraesthesia oral 15.16 9.28 86 422467 31573 90174321
Ventricular hypokinesia 15.11 9.28 57 422496 5284 90200610
Cellulitis 15.00 9.28 318 422235 91019 90114875
Tuberculosis 14.99 9.28 22 422531 12527 90193367
Aspergillus infection 14.97 9.28 17 422536 10806 90195088
Diaphragmatic rupture 14.94 9.28 11 422542 237 90205657
Water intoxication 14.90 9.28 16 422537 575 90205319
Morose 14.87 9.28 6 422547 35 90205859
Neonatal behavioural syndrome 14.84 9.28 8 422545 97 90205797
Mitochondrial encephalomyopathy 14.84 9.28 8 422545 97 90205797
Myositis 14.83 9.28 175 422378 23953 90181941
Abdominal pain 14.79 9.28 2083 420470 393638 89812256
Cardiac failure chronic 14.79 9.28 4 422549 5642 90200252
Dopamine transporter scintigraphy abnormal 14.77 9.28 8 422545 98 90205796
Nervousness 14.76 9.28 232 422321 33824 90172070
Procedural pain 14.71 9.28 93 422460 33267 90172627
Partial seizures 14.71 9.28 70 422483 7190 90198704
Drug screen false positive 14.69 9.28 20 422533 923 90204971
Apathy 14.69 9.28 95 422458 10945 90194949
Transplant rejection 14.63 9.28 23 422530 12735 90193159
Red blood cell sedimentation rate increased 14.63 9.28 284 422269 82311 90123583
Pathogen resistance 14.53 9.28 10 422543 8105 90197789
Benzodiazepine drug level increased 14.52 9.28 10 422543 193 90205701
Gout 14.49 9.28 36 422517 16823 90189071
Induced abortion failed 14.43 9.28 10 422543 195 90205699
Product preparation error 14.32 9.28 16 422537 10245 90195649
Monocyte count decreased 14.31 9.28 35 422518 2556 90203338
Hemiplegia 14.29 9.28 34 422519 16126 90189768
Joint destruction 14.27 9.28 25 422528 13262 90192632
Maternal exposure timing unspecified 14.23 9.28 164 422389 22319 90183575
Vomiting 14.23 9.28 4002 418551 784291 89421603
Burning sensation 14.23 9.28 209 422344 63243 90142651
Loss of libido 14.20 9.28 24 422529 1343 90204551
Thymus disorder 14.19 9.28 12 422541 318 90205576
Pallor 14.16 9.28 231 422322 33934 90171960
Differential white blood cell count abnormal 14.13 9.28 20 422533 958 90204936
pH urine increased 14.08 9.28 13 422540 388 90205506
Gastric ulcer 14.00 9.28 73 422480 27375 90178519
Cardiovascular disorder 13.94 9.28 26 422527 13466 90192428
Hypocoagulable state 13.93 9.28 26 422527 1573 90204321
Regressive behaviour 13.88 9.28 10 422543 208 90205686
Drug screen negative 13.81 9.28 12 422541 330 90205564
Deafness 13.79 9.28 56 422497 22458 90183436
Atonic seizures 13.78 9.28 18 422535 798 90205096
Diffuse large B-cell lymphoma 13.77 9.28 12 422541 8633 90197261
Retinitis 13.76 9.28 254 422299 38204 90167690
Endoscopic retrograde cholangiopancreatography 13.76 9.28 10 422543 211 90205683
Medication error 13.68 9.28 503 422050 84149 90121745
Pupillary reflex impaired 13.66 9.28 34 422519 2511 90203383
Injection site urticaria 13.58 9.28 41 422512 17970 90187924
Central nervous system necrosis 13.56 9.28 9 422544 163 90205731
Stillbirth 13.56 9.28 9 422544 7434 90198460
Exposure via skin contact 13.56 9.28 18 422535 10687 90195207
Diabetic ketoacidosis 13.55 9.28 63 422490 24344 90181550
Blood test abnormal 13.54 9.28 51 422502 20901 90184993
Drug level increased 13.54 9.28 193 422360 27569 90178325
Drug withdrawal syndrome neonatal 13.54 9.28 32 422521 2287 90203607
Swollen joint count increased 13.47 9.28 641 421912 110565 90095329
Breast cancer stage I 13.44 9.28 15 422538 9609 90196285
Foot fracture 13.44 9.28 71 422482 26535 90179359
Dependence 13.43 9.28 30 422523 2065 90203829
Musculoskeletal disorder 13.42 9.28 54 422499 21715 90184179
Wrong rate 13.42 9.28 9 422544 166 90205728
Hypercalcaemia 13.34 9.28 99 422454 34141 90171753
Eosinophil count decreased 13.30 9.28 39 422514 3173 90202721
Rhinitis 13.28 9.28 27 422526 13545 90192349
Oppositional defiant disorder 13.28 9.28 6 422547 48 90205846
Self-medication 13.25 9.28 39 422514 3181 90202713
Thrombosis 13.24 9.28 251 422302 73000 90132894
Blood lactic acid increased 13.23 9.28 78 422475 8700 90197194
Bronchial aspiration procedure 13.21 9.28 10 422543 225 90205669
Sinusitis 13.19 9.28 1399 421154 341689 89864205
Wrong drug 13.15 9.28 11 422542 287 90205607
Skin cancer 13.14 9.28 27 422526 13492 90192402
Antidepressant drug level below therapeutic 13.12 9.28 3 422550 0 90205894
Swollen joint count 13.12 9.28 77 422476 8576 90197318
Sickle cell anaemia with crisis 13.06 9.28 9 422544 7288 90198606
Multiple organ dysfunction syndrome 13.02 9.28 232 422321 68104 90137790
Maximal voluntary ventilation abnormal 13.02 9.28 5 422548 25 90205869
Nail bed inflammation 12.93 9.28 27 422526 1774 90204120
Tooth hypoplasia 12.90 9.28 7 422546 86 90205808
Endophthalmitis 12.89 9.28 3 422550 4682 90201212
Influenza like illness 12.85 9.28 282 422271 80329 90125565
Autologous bone marrow transplantation therapy 12.82 9.28 4 422549 9 90205885
Chest discomfort 12.81 9.28 521 422032 137844 90068050
Hepatic cytolysis 12.72 9.28 88 422465 30828 90175066
Illness 12.71 9.28 288 422265 81681 90124213
Pulmonary pain 12.70 9.28 4 422549 5110 90200784
Atrial tachycardia 12.70 9.28 6 422547 5984 90199910
Thinking abnormal 12.70 9.28 96 422457 11636 90194258
Substance-induced psychotic disorder 12.68 9.28 36 422517 2876 90203018
Anxiety disorder 12.68 9.28 51 422502 4871 90201023
Lip swelling 12.61 9.28 117 422436 38493 90167401
Muscle contractions involuntary 12.56 9.28 36 422517 2892 90203002
Congenital pneumonia 12.53 9.28 4 422549 10 90205884
Incorrect product administration duration 12.51 9.28 47 422506 19275 90186619
Injection site discolouration 12.50 9.28 15 422538 9305 90196589
Intentional product misuse 12.50 9.28 524 422029 89080 90116814
Pleural adhesion 12.50 9.28 7 422546 92 90205802
Electrocardiogram T wave abnormal 12.47 9.28 34 422519 2654 90203240
Visceral congestion 12.46 9.28 12 422541 378 90205516
Cholangitis infective 12.45 9.28 13 422540 452 90205442
Gastrointestinal sounds abnormal 12.45 9.28 48 422505 4495 90201399
Troponin T increased 12.44 9.28 25 422528 1598 90204296
Stomatitis 12.43 9.28 1463 421090 273235 89932659
Sputum discoloured 12.31 9.28 51 422502 20340 90185554
Arrhythmia 12.29 9.28 271 422282 42061 90163833
Vulvar basal cell carcinoma 12.28 9.28 5 422548 30 90205864
Leukopenia neonatal 12.28 9.28 5 422548 30 90205864
Irritability 12.23 9.28 234 422319 35428 90170466
Ovarian hyperstimulation syndrome 12.23 9.28 6 422547 5856 90200038
Cerebellar haematoma 12.21 9.28 12 422541 388 90205506
Walking aid user 12.19 9.28 233 422320 35273 90170621
Parachute mitral valve 12.17 9.28 7 422546 97 90205797
Electrocardiogram abnormal 12.14 9.28 86 422467 10212 90195682
BK virus infection 12.14 9.28 3 422550 4495 90201399
Nasopharyngitis 12.14 9.28 1688 420865 405416 89800478
Cognitive disorder 12.10 9.28 416 422137 68991 90136903
Chronic kidney disease 12.07 9.28 163 422390 50028 90155866
Seronegative arthritis 12.04 9.28 44 422509 18190 90187704
Inappropriate affect 12.00 9.28 19 422534 1006 90204888
Kluver-Bucy syndrome 12.00 9.28 4 422549 12 90205882
Melaena 12.00 9.28 104 422449 34693 90171201
Delusion of grandeur 11.98 9.28 10 422543 260 90205634
Colitis microscopic 11.98 9.28 21 422532 11138 90194756
Postural tremor 11.98 9.28 13 422540 473 90205421
Drug clearance decreased 11.97 9.28 27 422526 1871 90204023
Injection site haemorrhage 11.95 9.28 80 422473 28238 90177656
Systolic dysfunction 11.91 9.28 27 422526 1877 90204017
Rabbit syndrome 11.89 9.28 11 422542 329 90205565
Arterial spasm 11.80 9.28 6 422547 64 90205830
Depressive delusion 11.76 9.28 4 422549 13 90205881
Mucosal dryness 11.75 9.28 37 422516 3130 90202764
Hypervigilance 11.72 9.28 13 422540 485 90205409
Drug diversion 11.70 9.28 19 422534 1028 90204866
Bone marrow failure 11.70 9.28 95 422458 32126 90173768
Genital haemorrhage 11.68 9.28 14 422539 8688 90197206
Neutrophil Pelger-Huet anomaly present 11.63 9.28 7 422546 106 90205788
Ventricular compliance decreased 11.63 9.28 5 422548 35 90205859
Autonomic nervous system imbalance 11.63 9.28 39 422514 3411 90202483
Myelodysplastic syndrome 11.58 9.28 54 422499 20849 90185045
Squamous cell carcinoma of the oral cavity 11.57 9.28 12 422541 414 90205480
Urine ketone body present 11.56 9.28 32 422521 2520 90203374
Tachyphylaxis 11.54 9.28 11 422542 342 90205552
Malignant mesenteric neoplasm 11.54 9.28 4 422549 14 90205880
Verbal abuse 11.52 9.28 7 422546 108 90205786
Wrong technique in product usage process 11.51 9.28 250 422303 71321 90134573
Metabolic encephalopathy 11.50 9.28 62 422491 6690 90199204
Pressure of speech 11.50 9.28 16 422537 754 90205140
Cyanosis 11.47 9.28 140 422413 19315 90186579
Peritonitis 11.46 9.28 50 422503 19655 90186239
Incision site complication 11.41 9.28 15 422538 669 90205225
Neutropenia 11.40 9.28 898 421655 224006 89981888
Scleritis 11.38 9.28 5 422548 5203 90200691
Atypical femur fracture 11.38 9.28 8 422545 6413 90199481
Infective pulmonary exacerbation of cystic fibrosis 11.35 9.28 19 422534 10260 90195634
Impulsive behaviour 11.35 9.28 25 422528 1705 90204189
Hypoprolactinaemia 11.33 9.28 4 422549 15 90205879
Skin toxicity 11.30 9.28 9 422544 6770 90199124
Paraesthesia 11.30 9.28 1333 421220 248993 89956901
Pulmonary alveolar haemorrhage 11.27 9.28 7 422546 5991 90199903
Localised infection 11.27 9.28 101 422452 33461 90172433
Dermatitis exfoliative generalised 11.26 9.28 6 422547 5587 90200307
Prescribed overdose 11.25 9.28 560 421993 97065 90108829
Nasal mucosal disorder 11.25 9.28 26 422527 1831 90204063
Blindness 11.24 9.28 75 422478 26493 90179401
Pulmonary toxicity 11.24 9.28 23 422530 11508 90194386
Cholinergic syndrome 11.21 9.28 15 422538 681 90205213
Pruritus allergic 11.17 9.28 25 422528 1723 90204171
Discoloured vomit 11.17 9.28 20 422533 1172 90204722
Opsoclonus myoclonus 11.16 9.28 8 422545 165 90205729
Natural killer cell count 11.13 9.28 4 422549 16 90205878
Amegakaryocytic thrombocytopenia 11.13 9.28 4 422549 16 90205878
Cerebral atrophy 11.12 9.28 54 422499 5592 90200302
Rash macular 11.12 9.28 89 422464 30191 90175703
Gastrointestinal hypomotility 11.10 9.28 21 422532 1284 90204610
Blood bilirubin 11.05 9.28 3 422550 3 90205891
Colloid brain cyst 11.05 9.28 3 422550 3 90205891
Antidepressant drug level decreased 11.05 9.28 3 422550 3 90205891
Anti-neuronal antibody positive 11.05 9.28 3 422550 3 90205891
Patient restraint 11.05 9.28 3 422550 3 90205891
Benzodiazepine drug level 11.05 9.28 3 422550 3 90205891
Cerebrovascular accident 11.04 9.28 467 422086 123066 90082828
Hypersomnia 11.04 9.28 151 422402 21380 90184514
Drug specific antibody present 10.98 9.28 6 422547 5508 90200386
Polydipsia psychogenic 10.93 9.28 7 422546 119 90205775
Neoplasm malignant 10.92 9.28 103 422450 33777 90172117
Oral candidiasis 10.92 9.28 109 422444 35346 90170548
Stereotypy 10.89 9.28 12 422541 444 90205450
Incoherent 10.83 9.28 49 422504 4928 90200966
Skin disorder 10.83 9.28 114 422439 36592 90169302
Delusional perception 10.82 9.28 9 422544 233 90205661
Grandiosity 10.82 9.28 10 422543 299 90205595
Ocular hyperaemia 10.79 9.28 103 422450 33695 90172199
Product use in unapproved indication 10.75 9.28 1388 421165 334848 89871046
Trichoglossia 10.74 9.28 12 422541 451 90205443
Negativism 10.74 9.28 12 422541 451 90205443
Secretion discharge 10.73 9.28 38 422515 15858 90190036
Chronic graft versus host disease 10.71 9.28 3 422550 4136 90201758
Skin lesion 10.64 9.28 117 422436 37248 90168646
Toxicologic test abnormal 10.62 9.28 15 422538 717 90205177
Platelet morphology abnormal 10.58 9.28 4 422549 19 90205875
Hemiparesis 10.57 9.28 96 422457 31723 90174171
Mycobacterium avium complex infection 10.55 9.28 3 422550 4095 90201799
No adverse event 10.50 9.28 239 422314 67743 90138151
Tachyphrenia 10.46 9.28 24 422529 1682 90204212
Hypoaesthesia oral 10.42 9.28 115 422438 15485 90190409
Moaning 10.42 9.28 18 422535 1025 90204869
Affective ambivalence 10.42 9.28 4 422549 20 90205874
Iron deficiency 10.40 9.28 18 422535 9594 90196300
Maternal exposure before pregnancy 10.40 9.28 23 422530 11190 90194704
Infusion site erythema 10.39 9.28 31 422522 13639 90192255
Dysmetropsia 10.38 9.28 6 422547 84 90205810
Dysphagia 10.37 9.28 631 421922 111647 90094247
Sluggishness 10.34 9.28 55 422498 5904 90199990
Bipolar I disorder 10.33 9.28 27 422526 2055 90203839
Soft tissue swelling 10.30 9.28 21 422532 1357 90204537
Retinal detachment 10.24 9.28 10 422543 6812 90199082
Schizoaffective disorder bipolar type 10.23 9.28 8 422545 189 90205705
Hyponatraemic syndrome 10.22 9.28 13 422540 561 90205333
Drug withdrawal convulsions 10.21 9.28 22 422531 1478 90204416
Abortion spontaneous complete 10.20 9.28 3 422550 5 90205889
Product complaint 10.18 9.28 102 422451 13398 90192496
Locked-in syndrome 10.15 9.28 12 422541 480 90205414
Muscle mass 10.13 9.28 7 422546 136 90205758
Focal dyscognitive seizures 10.12 9.28 35 422518 3109 90202785
Pain in jaw 10.09 9.28 160 422393 47825 90158069
Breast cancer 10.09 9.28 183 422370 53578 90152316
Hospitalisation 10.08 9.28 491 422062 127609 90078285
Polycystic ovaries 10.08 9.28 7 422546 5647 90200247
Creatinine urine increased 10.08 9.28 9 422544 257 90205637
Pulmonary arterial hypertension 10.07 9.28 76 422477 26111 90179783
Tongue movement disturbance 10.05 9.28 11 422542 404 90205490
Blood albumin increased 9.99 9.28 19 422534 1166 90204728
Productive cough 9.99 9.28 278 422275 76785 90129109
Macrophages increased 9.96 9.28 4 422549 23 90205871
Hypotonia 9.95 9.28 89 422464 11337 90194557
Venoocclusive liver disease 9.94 9.28 8 422545 5985 90199909
Condition aggravated 9.93 9.28 2546 420007 592999 89612895
Acne 9.92 9.28 85 422468 28422 90177472
Parkinsonian gait 9.91 9.28 13 422540 579 90205315
Fall 9.90 9.28 2460 420093 479350 89726544
Acute hepatic failure 9.90 9.28 63 422490 22498 90183396
Meningitis enterococcal 9.85 9.28 3 422550 6 90205888
Parkinson's disease 9.85 9.28 18 422535 1072 90204822
Hypertransaminasaemia 9.82 9.28 115 422438 15710 90190184
Morbihan disease 9.82 9.28 4 422549 24 90205870
Decreased immune responsiveness 9.82 9.28 16 422537 8732 90197162
Gallbladder cholesterolosis 9.78 9.28 15 422538 773 90205121
Cholelithiasis 9.77 9.28 179 422374 52327 90153567
Renal failure 9.76 9.28 505 422048 130502 90075392
Dermatitis bullous 9.70 9.28 21 422532 10295 90195599
Scleral haemorrhage 9.70 9.28 5 422548 55 90205839
Compulsions 9.68 9.28 8 422545 205 90205689
Muscle spasms 9.66 9.28 1328 421225 250555 89955339
Osteoporotic fracture 9.66 9.28 5 422548 4731 90201163
Brain herniation 9.63 9.28 42 422511 4158 90201736
Anuria 9.62 9.28 36 422517 14782 90191112
Cystitis 9.62 9.28 237 422316 66481 90139413
Electroconvulsive therapy 9.62 9.28 5 422548 56 90205838
Osteoradionecrosis 9.58 9.28 7 422546 149 90205745
Hepatic necrosis 9.57 9.28 57 422496 6381 90199513
Rash pruritic 9.56 9.28 301 422252 81913 90123981
Optic nerve sheath haemorrhage 9.54 9.28 3 422550 7 90205887
Skin maceration 9.52 9.28 8 422545 210 90205684
Infusion site reaction 9.51 9.28 51 422502 18988 90186906
Theft 9.47 9.28 6 422547 100 90205794
Anhedonia 9.43 9.28 88 422465 11343 90194551
Delusional disorder, unspecified type 9.40 9.28 11 422542 435 90205459
SARS-CoV-2 test positive 9.38 9.28 24 422529 11104 90194790
Tension 9.36 9.28 38 422515 3644 90202250
Vulvovaginal burning sensation 9.34 9.28 30 422523 2565 90203329
Bronchopulmonary aspergillosis 9.29 9.28 25 422528 11373 90194521
Limbic encephalitis 9.28 9.28 9 422544 286 90205608

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sopor 940.94 10.83 620 175954 12582 42432179
Drug abuse 670.32 10.83 1395 175179 103376 42341385
Neuroleptic malignant syndrome 548.85 10.83 554 176020 20918 42423843
Agitation 524.23 10.83 949 175625 63365 42381396
Aggression 458.43 10.83 726 175848 43437 42401324
Catatonia 401.28 10.83 275 176299 5964 42438797
Completed suicide 400.64 10.83 1086 175488 95379 42349382
Sedation 387.63 10.83 551 176023 29924 42414837
Intentional self-injury 378.92 10.83 387 176187 14815 42429946
Bradyphrenia 350.45 10.83 237 176337 5025 42439736
Psychotic disorder 343.67 10.83 509 176065 28699 42416062
Suicide attempt 340.15 10.83 652 175922 45448 42399313
Delirium 337.38 10.83 701 175873 51818 42392943
Somnolence 254.49 10.83 1208 175366 139897 42304864
Extrapyramidal disorder 248.49 10.83 323 176251 16089 42428672
Restlessness 209.95 10.83 409 176165 28840 42415921
Anxiety 201.44 10.83 998 175576 117562 42327199
Hallucination, auditory 201.23 10.83 277 176297 14587 42430174
Intentional overdose 195.35 10.83 561 176013 50895 42393866
Overdose 193.91 10.83 907 175667 104357 42340404
Drug dependence 187.51 10.83 389 176185 28705 42416056
Schizophrenia 187.48 10.83 225 176349 10325 42434436
Febrile neutropenia 185.13 10.83 1360 175214 184343 42260418
Drug withdrawal syndrome 184.37 10.83 325 176249 21224 42423537
Confusional state 183.71 10.83 1256 175318 166341 42278420
Dysarthria 174.98 10.83 458 176116 39349 42405412
Abnormal behaviour 170.86 10.83 354 176220 26097 42418664
Depressed level of consciousness 145.78 10.83 484 176090 47486 42397275
Respiratory depression 144.20 10.83 271 176303 18597 42426164
Suicidal ideation 143.76 10.83 483 176091 47678 42397083
Muscle rigidity 133.04 10.83 204 176370 11855 42432906
Interstitial lung disease 124.87 10.83 86 176488 78376 42366385
Toxicity to various agents 124.67 10.83 1474 175100 227662 42217099
Myelosuppression 124.05 10.83 12 176562 40449 42404312
Tachycardia 123.64 10.83 779 175795 100308 42344453
Substance abuse 123.62 10.83 168 176406 8737 42436024
Disorientation 123.15 10.83 381 176193 36008 42408753
Mental status changes 119.23 10.83 415 176159 41700 42403061
Salivary hypersecretion 119.15 10.83 184 176390 10759 42434002
Withdrawal syndrome 118.91 10.83 217 176357 14558 42430203
Bradykinesia 118.71 10.83 129 176445 5307 42439454
Parkinsonism 117.60 10.83 180 176394 10443 42434318
Dystonia 112.12 10.83 195 176379 12595 42432166
Delusion 111.81 10.83 211 176363 14523 42430238
Seizure 111.00 10.83 867 175707 119694 42325067
Mental impairment 100.52 10.83 182 176392 12135 42432626
Drug interaction 98.93 10.83 1604 174970 265395 42179366
Treatment noncompliance 97.08 10.83 360 176214 37312 42407449
Pruritus 95.81 10.83 429 176145 188342 42256419
Ataxia 95.10 10.83 208 176366 15917 42428844
Delusion of grandeur 92.10 10.83 72 176502 1924 42442837
Blood creatine phosphokinase increased 87.06 10.83 414 176160 47924 42396837
Serotonin syndrome 86.88 10.83 270 176304 25575 42419186
Akathisia 84.74 10.83 154 176420 10297 42434464
Sedation complication 79.50 10.83 78 176496 2841 42441920
Product dose omission issue 78.78 10.83 350 176224 154015 42290746
Coma 77.86 10.83 432 176142 53122 42391639
Unresponsive to stimuli 76.69 10.83 295 176279 31108 42413653
COVID-19 76.09 10.83 237 176337 115711 42329050
Thinking abnormal 73.23 10.83 117 176457 7044 42437717
Psychomotor hyperactivity 72.33 10.83 148 176426 10810 42433951
Joint swelling 72.25 10.83 106 176468 67916 42376845
Dyskinesia 71.68 10.83 250 176324 25140 42419621
Hallucination 71.39 10.83 445 176129 57062 42387699
Respiratory arrest 71.04 10.83 269 176305 28155 42416606
Rash 69.48 10.83 773 175801 276181 42168580
Anaemia 69.24 10.83 785 175789 279493 42165268
Speech disorder 69.02 10.83 271 176303 28850 42415911
Lethargy 67.99 10.83 378 176196 46512 42398249
Acute kidney injury 67.58 10.83 1093 175481 366244 42078517
Insomnia 66.95 10.83 767 175807 117486 42327275
Paranoia 65.34 10.83 165 176409 13861 42430900
Eczema 64.78 10.83 30 176544 34056 42410705
Rheumatoid arthritis 64.26 10.83 49 176525 42391 42402370
Irritability 63.65 10.83 258 176316 27870 42416891
Needle fatigue 63.11 10.83 47 176527 1166 42443595
Rhabdomyolysis 63.10 10.83 545 176029 77474 42367287
Arthralgia 62.69 10.83 546 176028 204692 42240069
Miosis 62.45 10.83 158 176416 13288 42431473
Electrocardiogram QT prolonged 62.03 10.83 375 176199 47570 42397191
Renal impairment 61.76 10.83 241 176333 109987 42334774
Psychotic behaviour 61.22 10.83 42 176532 912 42443849
Gait spastic 61.09 10.83 49 176525 1360 42443401
Tremor 60.97 10.83 642 175932 96287 42348474
Paradoxical drug reaction 60.69 10.83 86 176488 4652 42440109
Multiple organ dysfunction syndrome 59.73 10.83 204 176370 96831 42347930
Cytomegalovirus infection 59.01 10.83 30 176544 32276 42412485
Priapism 57.88 10.83 99 176475 6308 42438453
Affective disorder 57.71 10.83 95 176479 5865 42438896
Antipsychotic drug level decreased 57.15 10.83 44 176530 1149 42443612
Withdrawal catatonia 56.12 10.83 25 176549 220 42444541
Granulocytopenia 55.37 10.83 103 176471 7011 42437750
Refusal of treatment by patient 54.86 10.83 87 176487 5204 42439557
Relapsing-remitting multiple sclerosis 54.45 10.83 47 176527 1448 42443313
Anaphylactic shock 54.38 10.83 15 176559 23502 42421259
Negativism 53.63 10.83 29 176545 402 42444359
Mental disorder 52.17 10.83 179 176395 17850 42426911
Sexually inappropriate behaviour 51.15 10.83 32 176542 591 42444170
Movement disorder 49.81 10.83 154 176420 14544 42430217
Pneumonia aspiration 49.30 10.83 366 176208 49712 42395049
Hypokinesia 49.02 10.83 119 176455 9752 42435009
Antipsychotic drug level increased 48.76 10.83 77 176497 4589 42440172
Psoriasis 48.49 10.83 79 176495 48525 42396236
Peripheral swelling 48.26 10.83 201 176373 90069 42354692
Drug ineffective 47.73 10.83 2131 174443 628066 41816695
Child abuse 47.39 10.83 35 176539 857 42443904
Self-injurious ideation 47.34 10.83 48 176526 1820 42442941
Drug screen positive 47.14 10.83 71 176503 4060 42440701
Poverty of speech 47.04 10.83 22 176552 219 42444542
Prostate cancer 46.98 10.83 70 176504 44573 42400188
Victim of child abuse 46.62 10.83 39 176535 1150 42443611
Homicide 46.59 10.83 35 176539 880 42443881
Drug withdrawal convulsions 46.59 10.83 41 176533 1297 42443464
Rhinalgia 46.04 10.83 47 176527 1797 42442964
Incoherent 45.80 10.83 75 176499 4610 42440151
Tubulointerstitial nephritis 45.78 10.83 38 176536 31510 42413251
Major depression 45.62 10.83 81 176493 5317 42439444
Poisoning 45.24 10.83 149 176425 14550 42430211
Cardiac failure 44.95 10.83 259 176315 106597 42338164
Dyspnoea 44.90 10.83 1445 175129 441176 42003585
Sinus tachycardia 44.80 10.83 187 176387 20466 42424295
Hypersensitivity 44.63 10.83 152 176422 72218 42372543
Stupor 44.55 10.83 60 176514 3093 42441668
Hypertonic bladder 44.31 10.83 52 176522 2329 42442432
Injection site pain 43.93 10.83 110 176464 57688 42387073
Hepatic cytolysis 43.25 10.83 29 176545 26815 42417946
Panic reaction 43.02 10.83 44 176530 1686 42443075
Depression 42.97 10.83 674 175900 110689 42334072
Oropharyngeal spasm 42.68 10.83 20 176554 200 42444561
Hepatic function abnormal 42.50 10.83 94 176480 51473 42393288
Aplastic anaemia 42.19 10.83 130 176444 12254 42432507
Hyperkalaemia 41.87 10.83 181 176393 80277 42364484
Treatment failure 41.77 10.83 127 176447 62497 42382264
Intentional product misuse 41.77 10.83 416 176158 61484 42383277
Epidural lipomatosis 41.56 10.83 44 176530 1756 42443005
Psoriatic arthropathy 41.55 10.83 26 176548 24941 42419820
Anaphylactic reaction 41.22 10.83 71 176503 42672 42402089
Mania 40.97 10.83 116 176458 10431 42434330
Adjustment disorder 40.60 10.83 38 176536 1304 42443457
Dissociation 40.14 10.83 63 176511 3735 42441026
Psychomotor retardation 39.77 10.83 68 176506 4331 42440430
Parathyroid gland enlargement 39.58 10.83 18 176556 167 42444594
Drug reaction with eosinophilia and systemic symptoms 39.57 10.83 71 176503 42004 42402757
Status epilepticus 39.39 10.83 148 176426 15430 42429331
Psychotic symptom 39.26 10.83 49 176525 2341 42442420
Bladder cancer 39.18 10.83 11 176563 17036 42427725
Erythema 38.95 10.83 277 176297 108516 42336245
Upper respiratory fungal infection 38.76 10.83 18 176556 176 42444585
Dystonic tremor 38.53 10.83 22 176552 341 42444420
Substance-induced psychotic disorder 37.84 10.83 53 176521 2836 42441925
Pain in extremity 37.82 10.83 420 176154 150184 42294577
Lymphocyte count abnormal 37.80 10.83 46 176528 2141 42442620
Synovitis 37.78 10.83 9 176565 15558 42429203
Pulmonary fibrosis 37.66 10.83 33 176541 26648 42418113
Balance disorder 37.55 10.83 331 176243 47314 42397447
Anxiolytic therapy 37.48 10.83 13 176561 53 42444708
Cholestasis 37.14 10.83 49 176525 32830 42411931
Transplant rejection 36.87 10.83 6 176568 13582 42431179
Monoparesis 36.85 10.83 53 176521 2907 42441854
Iatrogenic injury 36.82 10.83 30 176544 852 42443909
Diet refusal 36.14 10.83 20 176554 291 42444470
Drug therapy enhancement 35.85 10.83 13 176561 62 42444699
Muscle spasticity 35.77 10.83 84 176490 6738 42438023
Anger 35.72 10.83 127 176447 12891 42431870
Memory impairment 35.58 10.83 341 176233 49881 42394880
Nervousness 35.42 10.83 130 176444 13402 42431359
Confabulation 35.41 10.83 16 176558 146 42444615
Amnesia 35.24 10.83 220 176354 28217 42416544
Arthritis 35.23 10.83 76 176498 41989 42402772
Depressed mood 34.88 10.83 190 176384 23194 42421567
Faecaloma 34.85 10.83 79 176495 6191 42438570
Slow speech 34.83 10.83 40 176534 1750 42443011
Affect lability 34.59 10.83 61 176513 3983 42440778
Fear 34.51 10.83 112 176462 10853 42433908
Urinary incontinence 34.33 10.83 179 176395 21489 42423272
Hyperprolactinaemia 34.04 10.83 43 176531 2080 42442681
Impulsive behaviour 34.04 10.83 46 176528 2379 42442382
End stage renal disease 33.98 10.83 13 176561 16545 42428216
Neologism 33.39 10.83 8 176566 3 42444758
Haematuria 33.24 10.83 125 176449 57674 42387087
Myocardial fibrosis 32.75 10.83 33 176541 1242 42443519
Hyperammonaemic encephalopathy 32.33 10.83 48 176526 2710 42442051
Cognitive disorder 32.08 10.83 247 176327 33925 42410836
Frequent bowel movements 32.04 10.83 25 176549 21382 42423379
Dysphoria 32.03 10.83 48 176526 2732 42442029
Nephropathy toxic 31.71 10.83 15 176559 16823 42427938
Blood prolactin increased 31.36 10.83 43 176531 2255 42442506
Sexual dysfunction 30.83 10.83 79 176495 6696 42438065
Panic attack 30.52 10.83 108 176466 10937 42433824
Loss of consciousness 30.49 10.83 545 176029 91809 42352952
Ascites 30.41 10.83 126 176448 56552 42388209
Urticaria 30.30 10.83 181 176393 73855 42370906
Hangover 30.23 10.83 30 176544 1108 42443653
Respiratory symptom 29.92 10.83 5 176569 11101 42433660
Eyelid function disorder 29.78 10.83 15 176559 178 42444583
Appendicitis 29.70 10.83 25 176549 20588 42424173
Off label use 29.69 10.83 2261 174313 636074 41808687
Self-destructive behaviour 29.67 10.83 19 176555 366 42444395
Generalised tonic-clonic seizure 29.58 10.83 199 176375 26180 42418581
Epstein-Barr virus infection 29.47 10.83 3 176571 9715 42435046
Haematotoxicity 29.47 10.83 5 176569 10980 42433781
Myasthenia gravis 29.44 10.83 15 176559 16122 42428639
Forced expiratory volume 29.32 10.83 13 176561 113 42444648
Fall 29.30 10.83 1219 175355 233301 42211460
Bone marrow failure 29.22 10.83 58 176516 33035 42411726
Alcohol withdrawal syndrome 29.21 10.83 33 176541 1418 42443343
Visceral congestion 29.15 10.83 27 176547 914 42443847
Oral discharge 29.12 10.83 14 176560 149 42444612
Rhinitis perennial 29.06 10.83 15 176559 188 42444573
Pathogen resistance 29.04 10.83 6 176568 11444 42433317
Mutism 29.00 10.83 33 176541 1429 42443332
Screaming 28.97 10.83 38 176536 1909 42442852
Liver disorder 28.93 10.83 77 176497 39567 42405194
Logorrhoea 28.89 10.83 46 176528 2761 42442000
Oculogyric crisis 28.70 10.83 36 176538 1729 42443032
Impaired driving ability 28.47 10.83 47 176527 2908 42441853
Thrombosis 28.30 10.83 167 176407 68344 42376417
Juvenile idiopathic arthritis 28.20 10.83 44 176530 2595 42442166
Disorganised speech 27.94 10.83 32 176542 1396 42443365
COVID-19 pneumonia 27.86 10.83 29 176545 21584 42423177
Social avoidant behaviour 27.82 10.83 50 176524 3314 42441447
Injection site swelling 27.80 10.83 18 176556 16955 42427806
Arthropathy 27.78 10.83 50 176524 29547 42415214
Angioedema 27.71 10.83 87 176487 42390 42402371
Impaired quality of life 27.68 10.83 12 176562 14165 42430596
Lung disorder 27.32 10.83 104 176470 47819 42396942
Communication disorder 27.31 10.83 45 176529 2780 42441981
Antipsychotic drug level above therapeutic 27.22 10.83 30 176544 1254 42443507
Bipolar disorder 27.11 10.83 54 176520 3868 42440893
Hyperphosphataemia 27.04 10.83 10 176564 12994 42431767
Disturbance in attention 27.00 10.83 214 176360 29652 42415109
Diarrhoea 26.97 10.83 1599 174975 459250 41985511
Pleurothotonus 26.90 10.83 29 176545 1182 42443579
Hypogammaglobulinaemia 26.73 10.83 8 176566 11883 42432878
Nasal congestion 26.66 10.83 51 176523 29450 42415311
Malignant catatonia 26.64 10.83 19 176555 440 42444321
Neutrophil count increased 26.30 10.83 156 176418 19648 42425113
Pyrexia 26.21 10.83 1350 175224 392692 42052069
Blood uric acid increased 26.13 10.83 16 176558 15531 42429230
Dysphagia 26.12 10.83 435 176139 72284 42372477
Cytomegalovirus infection reactivation 26.09 10.83 7 176567 11171 42433590
Failure to thrive 25.92 10.83 92 176482 9330 42435431
Intentional product use issue 25.65 10.83 183 176391 71650 42373111
Gastrointestinal haemorrhage 25.53 10.83 270 176304 97456 42347305
Kidney transplant rejection 25.52 10.83 3 176571 8680 42436081
Cardiac arrest 25.22 10.83 612 175962 108708 42336053
Oedema peripheral 25.21 10.83 404 176170 135672 42309089
Proteinuria 25.20 10.83 35 176539 22948 42421813
Cough 25.18 10.83 554 176020 177549 42267212
Inappropriate antidiuretic hormone secretion 25.08 10.83 135 176439 16406 42428355
Multiple drug therapy 25.01 10.83 27 176547 1102 42443659
Therapeutic product effect decreased 24.97 10.83 81 176493 39069 42405692
Coronary artery disease 24.90 10.83 126 176448 53594 42391167
Parkinsonian gait 24.73 10.83 20 176554 562 42444199
Cardiac failure congestive 24.66 10.83 231 176343 85371 42359390
Blood creatine phosphokinase 24.19 10.83 11 176563 102 42444659
Obsessive-compulsive disorder 24.11 10.83 72 176502 6671 42438090
Blood sodium decreased 23.44 10.83 142 176432 18020 42426741
Acute myocardial infarction 23.38 10.83 143 176431 58022 42386739
Soliloquy 23.37 10.83 20 176554 609 42444152
C-reactive protein abnormal 23.18 10.83 5 176569 9256 42435505
Thrombocytopenia 23.02 10.83 606 175968 189673 42255088
Colitis ulcerative 23.00 10.83 46 176528 26129 42418632
Hyperreflexia 22.96 10.83 48 176526 3559 42441202
Negative thoughts 22.92 10.83 21 176553 701 42444060
Cerebrovascular accident 22.80 10.83 275 176299 96885 42347876
Suicidal behaviour 22.73 10.83 30 176544 1516 42443245
Cerebral haemorrhage 22.57 10.83 84 176490 38882 42405879
Skin exfoliation 22.52 10.83 92 176482 41461 42403300
Homicidal ideation 22.43 10.83 41 176533 2753 42442008
Myocardial infarction 22.36 10.83 370 176204 123639 42321122
Patient uncooperative 22.25 10.83 20 176554 651 42444110
Loose associations 22.21 10.83 9 176565 61 42444700
Hallucination, visual 22.04 10.83 156 176418 20864 42423897
Haematuria traumatic 21.69 10.83 15 176559 330 42444431
Pica 21.60 10.83 8 176566 41 42444720
Flight of ideas 21.58 10.83 15 176559 333 42444428
Pneumocystis jirovecii pneumonia 21.50 10.83 45 176529 25136 42419625
Immobilisation prolonged 21.48 10.83 6 176568 9 42444752
Muscle contracture 21.34 10.83 28 176546 1407 42443354
Testicular atrophy 21.28 10.83 19 176555 613 42444148
Emotional disorder 21.25 10.83 66 176508 6248 42438513
Plasma cell myeloma 21.09 10.83 295 176279 47283 42397478
Swelling 20.99 10.83 137 176437 54748 42390013
Hypocalcaemia 20.98 10.83 60 176514 30113 42414648
Pressure of speech 20.95 10.83 18 176556 551 42444210
Perseveration 20.92 10.83 10 176564 105 42444656
Emotional distress 20.88 10.83 126 176448 15967 42428794
Hyperosmolar state 20.86 10.83 17 176557 483 42444278
Torticollis 20.79 10.83 27 176547 1343 42443418
Immune reconstitution inflammatory syndrome 20.75 10.83 8 176566 10135 42434626
Neglect of personal appearance 20.75 10.83 15 176559 355 42444406
Dysphemia 20.73 10.83 32 176542 1870 42442891
Infection 20.66 10.83 333 176241 111735 42333026
Hypoglycaemia 20.64 10.83 154 176420 59700 42385061
Renal disorder 20.61 10.83 57 176517 28923 42415838
Drooling 20.47 10.83 51 176523 4248 42440513
Haematochezia 20.31 10.83 150 176424 58286 42386475
Foreign body aspiration 20.25 10.83 14 176560 308 42444453
Vasculitis 20.18 10.83 28 176546 18366 42426395
Pulmonary alveolar haemorrhage 20.11 10.83 19 176555 14797 42429964
Contraindicated product administered 20.06 10.83 47 176527 25225 42419536
Basal cell carcinoma 19.94 10.83 40 176534 22693 42422068
Hyperventilation 19.85 10.83 42 176532 3140 42441621
Immunosuppressant drug level increased 19.71 10.83 4 176570 7727 42437034
Myocarditis 19.54 10.83 140 176434 18798 42425963
Rebound effect 19.40 10.83 71 176503 7308 42437453
Vomiting projectile 19.37 10.83 20 176554 775 42443986
Enterococcus test positive 19.28 10.83 29 176545 1656 42443105
Cardiogenic shock 19.26 10.83 79 176495 35561 42409200
Staring 19.20 10.83 28 176546 1555 42443206
Bronchiectasis 19.20 10.83 28 176546 17991 42426770
Coordination abnormal 19.14 10.83 75 176499 7975 42436786
Drug eruption 19.06 10.83 42 176532 23033 42421728
Injection site erythema 19.06 10.83 34 176540 20161 42424600
Visual acuity reduced 18.97 10.83 27 176547 17523 42427238
Thrombotic microangiopathy 18.86 10.83 20 176554 14762 42429999
Orgasmic sensation decreased 18.83 10.83 8 176566 62 42444699
Persecutory delusion 18.81 10.83 44 176530 3520 42441241
Haemophagocytic lymphohistiocytosis 18.75 10.83 29 176545 18193 42426568
Hyperthermia 18.64 10.83 102 176472 12472 42432289
Middle insomnia 18.64 10.83 73 176501 7760 42437001
Pollakiuria 18.59 10.83 158 176416 22347 42422414
Chronic kidney disease 18.54 10.83 117 176457 47124 42397637
Respiratory rate decreased 18.52 10.83 39 176535 2906 42441855
Altered state of consciousness 18.47 10.83 194 176380 29065 42415696
Reduced facial expression 18.43 10.83 27 176547 1506 42443255
Septic shock 18.39 10.83 268 176306 91404 42353357
Illusion 18.37 10.83 22 176552 1007 42443754
Angina pectoris 18.35 10.83 72 176502 32824 42411937
Spasmodic dysphonia 18.21 10.83 16 176558 505 42444256
Herpes zoster 18.12 10.83 91 176483 38786 42405975
Muscle mass 18.05 10.83 12 176562 247 42444514
Purple glove syndrome 18.00 10.83 8 176566 70 42444691
Drug intolerance 17.97 10.83 230 176344 80194 42364567
Product use in unapproved indication 17.94 10.83 605 175969 183851 42260910
Nephrolithiasis 17.87 10.83 85 176489 36745 42408016
Feelings of worthlessness 17.86 10.83 13 176561 311 42444450
BK virus infection 17.85 10.83 7 176567 8777 42435984
Atrial fibrillation 17.83 10.83 441 176133 139152 42305609
Lactic acidosis 17.81 10.83 112 176462 45149 42399612
Thought insertion 17.79 10.83 6 176568 22 42444739
Growth hormone deficiency 17.72 10.83 13 176561 315 42444446
Mucosal inflammation 17.59 10.83 295 176279 49079 42395682
Infusion related reaction 17.54 10.83 164 176410 60642 42384119
Tuberculosis 17.53 10.83 10 176564 10089 42434672
Delirium tremens 17.42 10.83 17 176557 615 42444146
Ulcer 17.08 10.83 26 176548 16415 42428346
Porphyria acute 17.05 10.83 14 176560 402 42444359
Pulmonary embolism 16.91 10.83 372 176202 119240 42325521
Injection site pruritus 16.78 10.83 9 176565 9396 42435365
Neutropenic sepsis 16.77 10.83 25 176549 15921 42428840
Tenderness 16.65 10.83 77 176497 8806 42435955
Progressive multifocal leukoencephalopathy 16.61 10.83 14 176560 11522 42433239
Hypophosphataemia 16.59 10.83 39 176535 20906 42423855
Acute psychosis 16.58 10.83 31 176543 2118 42442643
Gastrointestinal disorder 16.58 10.83 119 176455 46534 42398227
Wrong patient received product 16.53 10.83 42 176532 3541 42441220
Systemic lupus erythematosus 16.52 10.83 9 176565 9315 42435446
Cogwheel rigidity 16.49 10.83 28 176546 1773 42442988
Drop attacks 16.48 10.83 16 176558 575 42444186
Bronchopulmonary aspergillosis 16.35 10.83 35 176539 19394 42425367
Self esteem decreased 16.21 10.83 15 176559 507 42444254
Bacterial infection 16.21 10.83 60 176514 27819 42416942
Mood swings 16.17 10.83 76 176498 8750 42436011
Feeling jittery 16.05 10.83 48 176526 4450 42440311
Psychiatric decompensation 15.97 10.83 46 176528 4176 42440585
Glycosylated haemoglobin increased 15.92 10.83 18 176556 12906 42431855
Gout 15.91 10.83 61 176513 27994 42416767
Cardiac disorder 15.88 10.83 128 176446 48804 42395957
Venous angioma of brain 15.85 10.83 6 176568 33 42444728
Breath sounds abnormal 15.84 10.83 16 176558 12077 42432684
Grandiosity 15.76 10.83 12 176562 308 42444453
Posturing 15.71 10.83 15 176559 528 42444233
Incorrect route of product administration 15.70 10.83 50 176524 24255 42420506
Cerebral infarction 15.67 10.83 71 176503 31098 42413663
Apnoea 15.65 10.83 69 176505 7734 42437027
No adverse event 15.64 10.83 96 176478 38925 42405836
Skin ulcer 15.62 10.83 54 176520 25547 42419214
Rash erythematous 15.60 10.83 74 176500 32017 42412744
Dermatitis atopic 15.59 10.83 17 176557 12387 42432374
Drug hypersensitivity 15.55 10.83 304 176270 99085 42345676
Hostility 15.54 10.83 18 176556 795 42443966
Hypomania 15.53 10.83 33 176541 2475 42442286
Skin irritation 15.45 10.83 6 176568 7568 42437193
Hepatotoxicity 15.41 10.83 53 176521 25114 42419647
Clumsiness 15.40 10.83 28 176546 1872 42442889
Central nervous system lesion 15.34 10.83 69 176505 7801 42436960
Floppy infant 15.30 10.83 9 176565 148 42444613
Benign prostatic hyperplasia 15.27 10.83 41 176533 21011 42423750
Myelodysplastic syndrome 15.25 10.83 46 176528 22699 42422062
Megacolon 15.24 10.83 31 176543 2254 42442507
Conjunctivitis allergic 15.19 10.83 3 176571 5908 42438853
Melaena 15.18 10.83 96 176478 38650 42406111
Erectile dysfunction 15.17 10.83 164 176410 24749 42420012
Dyspnoea exertional 15.01 10.83 134 176440 50014 42394747
Drug resistance 14.94 10.83 82 176492 34166 42410595
Illness 14.93 10.83 53 176521 24877 42419884
Oesophageal carcinoma 14.92 10.83 11 176563 9685 42435076
Obesity 14.91 10.83 118 176456 16341 42428420
Pain 14.90 10.83 846 175728 244002 42200759
Autonomic nervous system imbalance 14.87 10.83 37 176537 3079 42441682
Alcohol use 14.86 10.83 35 176539 2813 42441948
Drug use disorder 14.77 10.83 83 176491 10250 42434511
Pneumonia 14.72 10.83 1528 175046 420621 42024140
Schizoaffective disorder 14.68 10.83 28 176546 1942 42442819
Lip swelling 14.68 10.83 36 176538 19017 42425744
Skin necrosis 14.65 10.83 4 176570 6310 42438451
Somatic hallucination 14.64 10.83 6 176568 42 42444719
Blood osmolarity increased 14.62 10.83 13 176561 417 42444344
Nephrotic syndrome 14.61 10.83 9 176565 8709 42436052
Creutzfeldt-Jakob disease 14.52 10.83 6 176568 43 42444718
Hypophagia 14.41 10.83 173 176401 26783 42417978
Neuralgia 14.39 10.83 56 176518 25591 42419170
Hepatocellular carcinoma 14.39 10.83 8 176566 8186 42436575
Device issue 14.39 10.83 21 176553 13488 42431273
Ventricular fibrillation 14.33 10.83 70 176504 30053 42414708
Neuritis 14.32 10.83 4 176570 6216 42438545
Leukocytosis 14.31 10.83 187 176387 29521 42415240
Shoshin beriberi 14.28 10.83 7 176567 78 42444683
Premature ejaculation 14.18 10.83 8 176566 121 42444640
Device leakage 14.18 10.83 13 176561 10272 42434489
Hypoxia 14.13 10.83 384 176190 69402 42375359
Administration related reaction 14.12 10.83 9 176565 172 42444589
Myalgia 14.10 10.83 297 176277 95783 42348978
Intentional dose omission 14.09 10.83 10 176564 8976 42435785
Tachyphrenia 14.02 10.83 23 176551 1416 42443345
Bradycardia 13.96 10.83 458 176116 85026 42359735
Shock haemorrhagic 13.88 10.83 29 176545 16213 42428548
Staphylococcal infection 13.87 10.83 95 176479 37548 42407213
Daydreaming 13.81 10.83 16 176558 707 42444054
Blood phosphorus increased 13.80 10.83 19 176555 12506 42432255
Polyneuropathy 13.80 10.83 36 176538 18625 42426136
Dysgeusia 13.76 10.83 84 176490 34105 42410656
Opiates positive 13.76 10.83 14 176560 533 42444228
Electroencephalogram abnormal 13.73 10.83 35 176539 2957 42441804
Streptococcal bacteraemia 13.71 10.83 33 176541 2689 42442072
Vascular stenosis 13.67 10.83 9 176565 182 42444579
Poor quality sleep 13.61 10.83 76 176498 9364 42435397
Renal failure 13.60 10.83 473 176101 143253 42301508
Drug tolerance 13.58 10.83 37 176537 3253 42441508
Toxic epidermal necrolysis 13.57 10.83 170 176404 26580 42418181
Bundle branch block right 13.56 10.83 68 176506 8038 42436723
Product dose omission in error 13.49 10.83 9 176565 8345 42436416
Cardio-respiratory arrest 13.43 10.83 328 176246 58308 42386453
Cytomegalovirus viraemia 13.29 10.83 14 176560 10363 42434398
Dehydration 13.21 10.83 716 175858 141051 42303710
Nerve degeneration 13.10 10.83 9 176565 196 42444565
Congenital pulmonary valve atresia 13.07 10.83 6 176568 57 42444704
Accidental death 13.06 10.83 35 176539 3048 42441713
Head banging 13.02 10.83 9 176565 198 42444563
Hyperchloraemia 13.00 10.83 14 176560 570 42444191
Aspergillus infection 12.94 10.83 29 176545 15808 42428953
Physical assault 12.92 10.83 19 176555 1063 42443698
Malaise 12.91 10.83 733 175841 211423 42233338
Drug abuser 12.91 10.83 38 176536 3493 42441268
Jaundice 12.89 10.83 87 176487 34502 42410259
Red blood cell sedimentation rate decreased 12.86 10.83 10 176564 265 42444496
Nodule 12.85 10.83 20 176554 12514 42432247
Blood test abnormal 12.85 10.83 21 176553 12885 42431876
Cardiac failure acute 12.82 10.83 23 176551 13610 42431151
Parosmia 12.81 10.83 8 176566 7683 42437078
Nocturia 12.76 10.83 90 176484 12022 42432739
Cerebral atrophy 12.63 10.83 48 176526 5031 42439730
Gingival pain 12.61 10.83 10 176564 8484 42436277
Blood creatinine increased 12.59 10.83 353 176221 109650 42335111
Nephrogenic diabetes insipidus 12.51 10.83 23 176551 1551 42443210
Mucormycosis 12.50 10.83 7 176567 7136 42437625
Olfactory nerve disorder 12.47 10.83 6 176568 64 42444697
Waxy flexibility 12.46 10.83 7 176567 105 42444656
Hypersexuality 12.45 10.83 24 176550 1678 42443083
Prescribed overdose 12.44 10.83 94 176480 12833 42431928
Immune-mediated enterocolitis 12.43 10.83 4 176570 5673 42439088
Alcohol abuse 12.42 10.83 41 176533 4008 42440753
Crying 12.41 10.83 56 176518 6338 42438423
Ureteric obstruction 12.39 10.83 21 176553 1328 42443433
Behaviour disorder 12.39 10.83 60 176514 6994 42437767
Body temperature increased 12.39 10.83 134 176440 20224 42424537
Euglycaemic diabetic ketoacidosis 12.38 10.83 4 176570 5656 42439105
Emotional poverty 12.35 10.83 15 176559 697 42444064
Therapeutic product effect incomplete 12.34 10.83 213 176361 70726 42374035
Skin laceration 12.31 10.83 100 176474 13958 42430803
Poisoning deliberate 12.30 10.83 78 176496 10056 42434705
Sexual relationship change 12.23 10.83 4 176570 13 42444748
Anaemia of malignant disease 12.09 10.83 13 176561 528 42444233
Blood creatinine decreased 12.09 10.83 38 176536 3620 42441141
Mite allergy 12.08 10.83 3 176571 5043 42439718
Sepsis 12.07 10.83 689 175885 198645 42246116
Colorectal cancer 12.05 10.83 3 176571 5035 42439726
Poor sucking reflex 12.03 10.83 11 176563 366 42444395
Cytopenia 12.01 10.83 35 176539 17462 42427299
Eating disorder 11.95 10.83 76 176498 9809 42434952
Joint injury 11.89 10.83 27 176547 14649 42430112
Infective pulmonary exacerbation of cystic fibrosis 11.87 10.83 9 176565 7809 42436952
Pulmonary tuberculosis 11.83 10.83 4 176570 5497 42439264
Hyperammonaemia 11.79 10.83 64 176510 7802 42436959
Lymphocyte count decreased 11.75 10.83 171 176403 27638 42417123
Micturition urgency 11.73 10.83 87 176487 11811 42432950
Pancytopenia 11.71 10.83 385 176189 117358 42327403
Selective mutism 11.71 10.83 6 176568 74 42444687
Acute generalised exanthematous pustulosis 11.69 10.83 11 176563 8584 42436177
Derealisation 11.67 10.83 16 176558 839 42443922
Gait disturbance 11.66 10.83 507 176067 97493 42347268
Inappropriate affect 11.63 10.83 15 176559 741 42444020
Drug clearance decreased 11.62 10.83 27 176547 2151 42442610
Syringe issue 11.58 10.83 11 176563 8545 42436216
Drug-induced liver injury 11.57 10.83 102 176472 38171 42406590
Ischaemic stroke 11.57 10.83 50 176524 22183 42422578
Myositis 11.52 10.83 28 176546 14838 42429923
Lower respiratory tract infection 11.52 10.83 112 176462 41094 42403667
Palmar-plantar erythrodysaesthesia syndrome 11.51 10.83 45 176529 20537 42424224
Prostatic specific antigen increased 11.51 10.83 34 176540 16891 42427870
Tangentiality 11.49 10.83 7 176567 123 42444638
Acute stress disorder 11.49 10.83 8 176566 178 42444583
Premature baby 11.48 10.83 53 176521 23100 42421661
Foetal exposure during pregnancy 11.44 10.83 133 176441 47178 42397583
Thought withdrawal 11.41 10.83 3 176571 3 42444758
Dissociative disorder 11.40 10.83 14 176560 658 42444103
Fluid replacement 11.35 10.83 10 176564 317 42444444
Impaired reasoning 11.30 10.83 7 176567 127 42444634
Dermatitis exfoliative generalised 11.26 10.83 5 176569 5819 42438942
Dyspepsia 11.25 10.83 237 176337 41115 42403646
Inflammation 11.23 10.83 88 176486 33759 42411002
Neurological symptom 11.17 10.83 15 176559 9976 42434785
Dementia with Lewy bodies 11.13 10.83 16 176558 877 42443884
Haemoptysis 11.08 10.83 130 176444 46037 42398724
Knee arthroplasty 11.07 10.83 12 176562 8769 42435992
Transient ischaemic attack 11.07 10.83 88 176486 33651 42411110
Oral herpes 11.05 10.83 9 176565 7535 42437226
Transient acantholytic dermatosis 11.03 10.83 9 176565 256 42444505
Blood chloride decreased 11.03 10.83 40 176534 4099 42440662
Pneumonia fungal 10.99 10.83 13 176561 9133 42435628
Eye pruritus 10.96 10.83 19 176555 11393 42433368
Loss of personal independence in daily activities 10.93 10.83 143 176431 49673 42395088
Lymphopenia 10.91 10.83 49 176525 21514 42423247
Ocular hyperaemia 10.91 10.83 32 176542 15931 42428830
Swollen tongue 10.89 10.83 48 176526 21183 42423578
Hallucination, olfactory 10.89 10.83 9 176565 261 42444500
Injection site haemorrhage 10.86 10.83 20 176554 11716 42433045

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sopor 3003.47 9.79 1947 503853 34599 110048900
Drug abuse 1944.86 9.79 3154 502646 174257 109909242
Completed suicide 1204.46 9.79 3104 502696 239277 109844222
Neuroleptic malignant syndrome 1002.82 9.79 993 504807 33066 110050433
Intentional self-injury 887.79 9.79 972 504828 36457 110047042
Suicide attempt 845.23 9.79 1617 504183 101777 109981722
Agitation 767.88 9.79 1637 504163 111414 109972085
Bradyphrenia 672.23 9.79 501 505299 11227 110072272
Catatonia 632.72 9.79 476 505324 10824 110072675
Intentional overdose 605.76 9.79 1646 504154 130855 109952644
Delirium 602.02 9.79 1662 504138 133363 109950136
Somnolence 568.43 9.79 2779 503021 294670 109788829
Aggression 480.03 9.79 923 504877 58287 110025212
Overdose 430.60 9.79 2162 503638 231632 109851867
Toxicity to various agents 401.87 9.79 3651 502149 476904 109606595
Psychotic disorder 401.87 9.79 785 505015 50152 110033347
Extrapyramidal disorder 385.71 9.79 563 505237 28304 110055195
Drug withdrawal syndrome 383.38 9.79 652 505148 37402 110046097
Sedation 382.88 9.79 928 504872 68755 110014744
Serotonin syndrome 362.33 9.79 822 504978 58331 110025168
Coma 361.30 9.79 1274 504526 116595 109966904
Febrile neutropenia 343.38 9.79 2553 503247 314214 109769285
Suicidal ideation 342.81 9.79 1077 504723 92860 109990639
Restlessness 326.10 9.79 765 505035 55494 110028005
Anxiety 317.43 9.79 2678 503122 342400 109741099
Myelosuppression 308.72 9.79 35 505765 94305 109989194
Drug dependence 302.92 9.79 692 505108 49328 110034171
Confusional state 294.34 9.79 3358 502442 465322 109618177
Depressed level of consciousness 279.07 9.79 1135 504665 111143 109972356
Respiratory depression 271.89 9.79 509 505291 31492 110052007
Disorientation 255.76 9.79 808 504992 69863 110013636
Hallucination, auditory 245.97 9.79 437 505363 25960 110057539
Abnormal behaviour 240.74 9.79 544 505256 38495 110045004
Drug interaction 238.51 9.79 3406 502394 496777 109586722
Akathisia 236.26 9.79 339 505461 16774 110066725
Poisoning 231.33 9.79 450 505350 28655 110054844
Muscle rigidity 224.13 9.79 398 505402 23633 110059866
Dystonia 223.67 9.79 414 505386 25391 110058108
Substance abuse 222.73 9.79 280 505520 12183 110071316
Bradykinesia 219.83 9.79 259 505541 10529 110072970
Tachycardia 206.69 9.79 1756 504044 224889 109858610
Interstitial lung disease 203.37 9.79 202 505598 139132 109944367
COVID-19 201.83 9.79 520 505280 244540 109838959
Dissociation 198.41 9.79 235 505565 9607 110073892
Dysarthria 196.95 9.79 835 504965 83286 110000213
Speech disorder 191.64 9.79 669 505131 60900 110022599
Respiratory arrest 190.66 9.79 644 505156 57655 110025844
Withdrawal syndrome 188.75 9.79 433 505367 30947 110052552
Delusion 188.45 9.79 367 505433 23388 110060111
Salivary hypersecretion 188.18 9.79 308 505492 17113 110066386
Parkinsonism 186.12 9.79 351 505449 21836 110061663
Psychomotor hyperactivity 182.93 9.79 331 505469 19946 110063553
Mania 181.95 9.79 335 505465 20461 110063038
Pneumonia aspiration 174.67 9.79 786 505014 80447 110003052
Drug ineffective 171.12 9.79 5479 500321 1515061 108568438
Mental status changes 164.76 9.79 738 505062 75384 110008115
Dyskinesia 158.38 9.79 557 505243 50889 110032610
Rash 157.64 9.79 2724 503076 818240 109265259
Seizure 157.16 9.79 1625 504175 219560 109863939
Electrocardiogram QT prolonged 151.25 9.79 934 504866 108026 109975473
Tremor 149.05 9.79 1497 504303 200735 109882764
Off label use 145.73 9.79 5505 500295 1494680 108588819
Schizophrenia 140.01 9.79 309 505491 21517 110061982
Psychomotor retardation 137.56 9.79 174 505626 7618 110075881
Erythema 133.70 9.79 783 505017 290664 109792835
Drug intolerance 133.38 9.79 1202 504598 405310 109678189
Product dose omission issue 132.41 9.79 894 504906 320888 109762611
Cytomegalovirus infection 130.53 9.79 43 505757 54401 110029098
Anaemia 128.84 9.79 1745 504055 545341 109538158
Slow speech 127.28 9.79 114 505686 3334 110080165
Contraindicated product administered 123.68 9.79 649 505151 247618 109835881
Arthralgia 121.82 9.79 2678 503122 776954 109306545
Pain 121.13 9.79 3384 502416 951571 109131928
Acute kidney injury 120.99 9.79 2111 503689 633319 109450180
Mydriasis 119.45 9.79 293 505507 21864 110061635
Anaphylactic shock 117.93 9.79 44 505756 51502 110031997
Sinus tachycardia 117.10 9.79 458 505342 44035 110039464
Tardive dyskinesia 115.36 9.79 216 505584 13363 110070136
Unresponsive to stimuli 113.13 9.79 584 505216 63206 110020293
Hypokinesia 108.64 9.79 280 505520 21546 110061953
Coeliac disease 107.31 9.79 32 505768 43155 110040344
Therapeutic product effect decreased 106.98 9.79 666 505134 243650 109839849
Mental disorder 106.75 9.79 405 505395 38386 110045113
Injection site pain 105.83 9.79 436 505364 177486 109906013
Paranoia 105.21 9.79 281 505519 22093 110061406
Hallucination 104.36 9.79 808 504992 100624 109982875
Injection site reaction 102.66 9.79 155 505645 88915 109994584
Drooling 102.35 9.79 144 505656 6995 110076504
Deep vein thrombosis postoperative 101.82 9.79 538 505262 58753 110024746
Mutism 99.55 9.79 95 505705 3018 110080481
Mental impairment 99.15 9.79 277 505523 22362 110061137
Status epilepticus 98.19 9.79 343 505457 31228 110052271
Onychomycosis 96.74 9.79 28 505772 38503 110044996
Renal impairment 94.19 9.79 492 505308 187953 109895546
Amnesia 94.06 9.79 813 504987 104595 109978904
Delusion of grandeur 94.05 9.79 80 505720 2180 110081319
Finger deformity 92.94 9.79 19 505781 33073 110050426
Injection site erythema 91.14 9.79 183 505617 93993 109989506
Cogwheel rigidity 91.09 9.79 98 505702 3600 110079899
Depression 90.38 9.79 1992 503808 315343 109768156
Cardiac arrest 90.05 9.79 1331 504469 195422 109888077
Hypersensitivity 89.91 9.79 1303 504497 402695 109680804
Treatment failure 89.89 9.79 822 504978 276412 109807087
Major depression 87.81 9.79 167 505633 10454 110073045
Psoriasis 87.08 9.79 337 505463 139656 109943843
Hyperammonaemic encephalopathy 86.03 9.79 115 505685 5319 110078180
Autoimmune disorder 85.69 9.79 553 505247 64930 110018569
Ataxia 85.05 9.79 317 505483 29791 110053708
Loss of consciousness 83.29 9.79 1311 504489 194995 109888504
Myocardial depression 83.17 9.79 48 505752 684 110082815
Derealisation 82.94 9.79 73 505727 2085 110081414
Pruritus 82.49 9.79 2027 503773 579533 109503966
Miosis 81.04 9.79 253 505547 21730 110061769
Lower limb fracture 79.61 9.79 604 505196 74744 110008755
Lethargy 79.49 9.79 714 505086 92862 109990637
Blood creatine phosphokinase increased 79.02 9.79 589 505211 72488 110011011
Disorganised speech 78.68 9.79 86 505714 3217 110080282
Hepatic function abnormal 78.55 9.79 183 505617 89112 109994387
Stupor 78.51 9.79 138 505662 8127 110075372
Drug eruption 78.04 9.79 78 505722 53581 110029918
Therapeutic product effect incomplete 77.67 9.79 652 505148 223153 109860346
Gastric pH decreased 77.58 9.79 52 505748 978 110082521
Rheumatoid nodule 76.26 9.79 4 505796 20292 110063207
Joint swelling 76.14 9.79 1497 504303 441348 109642151
Emotional disorder 75.02 9.79 202 505598 15958 110067541
Treatment noncompliance 74.83 9.79 581 505219 72409 110011090
Device expulsion 74.75 9.79 24 505776 30867 110052632
Drug hypersensitivity 74.19 9.79 1548 504252 452542 109630957
Cough 72.73 9.79 1583 504217 460058 109623441
Homicide 71.91 9.79 51 505749 1055 110082444
Hypothermia 71.87 9.79 274 505526 26028 110057471
Cardiac failure 70.46 9.79 535 505265 187091 109896408
Pneumonia 69.98 9.79 3287 502513 873427 109210072
Multiple organ dysfunction syndrome 69.30 9.79 408 505392 151302 109932197
Hallucination, visual 69.12 9.79 361 505439 39244 110044255
Withdrawal catatonia 68.75 9.79 35 505765 382 110083117
Granulocytopenia 68.39 9.79 168 505632 12547 110070952
Onychomadesis 68.00 9.79 65 505735 45598 110037901
Coma scale abnormal 67.31 9.79 142 505658 9584 110073915
Injection site swelling 66.97 9.79 112 505688 61678 110021821
Psychotic behaviour 66.70 9.79 54 505746 1371 110082128
Incontinence 66.52 9.79 197 505603 16438 110067061
Pain in extremity 66.03 9.79 1709 504091 485409 109598090
Angioedema 65.93 9.79 230 505570 98270 109985229
Skin necrosis 65.53 9.79 10 505790 21502 110061997
Antipsychotic drug level increased 65.18 9.79 116 505684 6899 110076600
Lip dry 64.84 9.79 722 505078 99361 109984138
Aplastic anaemia 64.59 9.79 251 505549 24057 110059442
Rhabdomyolysis 64.19 9.79 837 504963 119564 109963935
Osmolar gap increased 64.04 9.79 27 505773 183 110083316
Tubulointerstitial nephritis 63.00 9.79 94 505706 54190 110029309
Prostate cancer 62.87 9.79 48 505752 37593 110045906
Skin exfoliation 62.55 9.79 199 505601 87452 109996047
Obesity 62.12 9.79 792 505008 112559 109970940
Eczema 62.12 9.79 150 505650 72143 110011356
Lupus vulgaris 62.03 9.79 313 505487 33570 110049929
Patient uncooperative 61.80 9.79 44 505756 916 110082583
Bronchiectasis 61.64 9.79 46 505754 36447 110047052
Blood prolactin increased 61.23 9.79 90 505710 4552 110078947
Feeling of despair 61.09 9.79 81 505719 3717 110079782
Persecutory delusion 61.00 9.79 106 505694 6185 110077314
Affective disorder 60.97 9.79 149 505651 11092 110072407
Dyspnoea 60.63 9.79 4303 501497 1102569 108980930
Hyperreflexia 60.52 9.79 134 505666 9351 110074148
Refusal of treatment by patient 60.43 9.79 134 505666 9360 110074139
Hallucinations, mixed 60.26 9.79 127 505673 8566 110074933
Adverse reaction 60.16 9.79 30 505770 29564 110053935
Cardio-respiratory arrest 59.98 9.79 801 504999 115035 109968464
Adjustment disorder with depressed mood 59.52 9.79 374 505426 43509 110039990
Depersonalisation/derealisation disorder 59.44 9.79 61 505739 2120 110081379
Haematotoxicity 59.42 9.79 12 505788 21070 110062429
Injection site pruritus 59.26 9.79 89 505711 51169 110032330
Screaming 59.20 9.79 91 505709 4790 110078709
Insomnia 58.81 9.79 2108 503692 358482 109725017
Impaired quality of life 58.70 9.79 32 505768 29985 110053514
Basal cell carcinoma 57.97 9.79 73 505727 45197 110038302
Hepatitis 57.15 9.79 215 505585 89839 109993660
Computerised tomogram thorax 55.82 9.79 33 505767 493 110083006
Gastrointestinal haemorrhage 55.71 9.79 486 505314 165032 109918467
Drug withdrawal convulsions 55.29 9.79 62 505738 2387 110081112
Blood lactic acid decreased 54.95 9.79 34 505766 554 110082945
Cytomegalovirus infection reactivation 54.77 9.79 9 505791 18324 110065175
Pneumocystis jirovecii pneumonia 54.63 9.79 69 505731 42666 110040833
Transplant rejection 54.50 9.79 22 505778 24545 110058954
Headache 54.37 9.79 3394 502406 878983 109204516
Negativism 53.94 9.79 40 505760 889 110082610
Electrocardiogram QRS complex prolonged 53.79 9.79 156 505644 12865 110070634
Irritability 53.77 9.79 389 505411 47420 110036079
Haematochezia 53.65 9.79 309 505491 115215 109968284
Needle fatigue 53.13 9.79 45 505755 1219 110082280
Anaphylactic reaction 52.94 9.79 306 505494 113994 109969505
Thrombocytopenia 52.16 9.79 1206 504594 347679 109735820
Computerised tomogram thorax abnormal 51.87 9.79 64 505736 2731 110080768
Porphyria acute 51.61 9.79 196 505604 18584 110064915
Hepatic cytolysis 51.55 9.79 109 505691 54944 110028555
Febrile bone marrow aplasia 51.24 9.79 9 505791 17456 110066043
Psychotic symptom 51.04 9.79 75 505725 3792 110079707
Gait spastic 50.92 9.79 48 505752 1501 110081998
Sexually inappropriate behaviour 50.84 9.79 34 505766 637 110082862
Brain injury 50.51 9.79 156 505644 13320 110070179
Grip strength 50.47 9.79 122 505678 9019 110074480
Head titubation 50.36 9.79 45 505755 1312 110082187
Neutropenic sepsis 50.34 9.79 40 505760 30706 110052793
Thrombosis 50.27 9.79 291 505509 108371 109975128
Rash erythematous 50.23 9.79 198 505602 81634 110001865
Respiratory rate decreased 50.02 9.79 97 505703 6161 110077338
Intentional product misuse 49.87 9.79 870 504930 132034 109951465
Red blood cell sedimentation rate abnormal 49.59 9.79 25 505775 24484 110059015
Priapism 49.50 9.79 93 505707 5768 110077731
Suicidal behaviour 49.34 9.79 70 505730 3427 110080072
Product label confusion 49.18 9.79 21 505779 22656 110060843
Bone marrow failure 48.94 9.79 121 505679 57727 110025772
Cardiac output increased 48.81 9.79 32 505768 579 110082920
Myoclonus 48.40 9.79 287 505513 32711 110050788
Cardiac failure congestive 48.36 9.79 449 505351 150551 109932948
Obsessive-compulsive disorder 48.13 9.79 104 505696 7137 110076362
Road traffic accident 48.12 9.79 724 505076 106674 109976825
End stage renal disease 48.01 9.79 19 505781 21454 110062045
Blood parathyroid hormone decreased 47.89 9.79 3 505797 13086 110070413
Liver function test increased 47.78 9.79 225 505575 88323 109995176
Haematuria 47.73 9.79 206 505594 82799 110000700
Cataract 47.73 9.79 194 505606 79291 110004208
Communication disorder 47.69 9.79 84 505716 4955 110078544
Joint injury 47.64 9.79 68 505732 39926 110043573
Feeling jittery 47.57 9.79 162 505638 14560 110068939
Logorrhoea 47.39 9.79 83 505717 4874 110078625
Rhinalgia 47.30 9.79 73 505727 3856 110079643
Peripheral venous disease 47.05 9.79 590 505210 83527 109999972
Mood swings 46.99 9.79 218 505582 22594 110060905
Bladder cancer 46.96 9.79 17 505783 20275 110063224
Haemophagocytic lymphohistiocytosis 46.90 9.79 45 505755 31514 110051985
Poisoning deliberate 46.63 9.79 241 505559 26090 110057409
Incoherent 46.63 9.79 112 505688 8246 110075253
Child abuse 46.58 9.79 36 505764 853 110082646
Panic attack 46.57 9.79 258 505542 28682 110054817
Skin ulcer 46.47 9.79 143 505657 63502 110019997
Tenosynovitis 46.46 9.79 9 505791 16274 110067225
Malaise 46.19 9.79 2557 503243 669262 109414237
Pathogen resistance 45.94 9.79 12 505788 17660 110065839
Substance-induced psychotic disorder 45.73 9.79 86 505714 5338 110078161
Somatic symptom disorder 45.70 9.79 64 505736 3095 110080404
Wrong patient received product 45.68 9.79 97 505703 6577 110076922
Angina pectoris 45.46 9.79 140 505660 62155 110021344
Upper respiratory tract infection 45.36 9.79 383 505417 130945 109952554
Mouth ulceration 45.34 9.79 95 505705 48043 110035456
Alcohol abuse 45.15 9.79 81 505719 4848 110078651
Hypoxia 45.13 9.79 838 504962 128677 109954822
Antipsychotic drug level decreased 44.98 9.79 43 505757 1369 110082130
Apnoea 44.88 9.79 151 505649 13488 110070011
Bezoar 44.22 9.79 72 505728 3982 110079517
Osteonecrosis of jaw 44.19 9.79 96 505704 47921 110035578
Ulcer 44.14 9.79 81 505719 43035 110040464
Thinking abnormal 44.10 9.79 161 505639 14979 110068520
Hypoglycaemia 44.08 9.79 330 505470 115774 109967725
Urinary incontinence 43.99 9.79 376 505424 48211 110035288
Loss of personal independence in daily activities 43.47 9.79 457 505343 149563 109933936
Night sweats 43.30 9.79 857 504943 133126 109950373
Nicotine dependence 43.29 9.79 41 505759 1290 110082209
Myocardial infarction 43.21 9.79 618 505182 191465 109892034
Behaviour disorder 43.20 9.79 119 505681 9528 110073971
Victim of child abuse 42.66 9.79 39 505761 1172 110082327
Myocardial fibrosis 42.49 9.79 49 505751 1946 110081553
Immunodeficiency 42.46 9.79 70 505730 38768 110044731
X-ray abnormal 42.21 9.79 309 505491 37808 110045691
Alcohol interaction 42.20 9.79 67 505733 3627 110079872
Poverty of speech 42.08 9.79 29 505771 572 110082927
Hyperchloraemia 42.04 9.79 40 505760 1266 110082233
Oropharyngeal spasm 41.94 9.79 27 505773 473 110083026
Drug reaction with eosinophilia and systemic symptoms 41.75 9.79 213 505587 81882 110001617
Device difficult to use 41.45 9.79 17 505783 18788 110064711
Electroencephalogram abnormal 41.42 9.79 89 505711 6084 110077415
Pleurothotonus 41.30 9.79 54 505746 2444 110081055
Bipolar disorder 41.22 9.79 112 505688 8895 110074604
Nervousness 40.96 9.79 299 505501 36552 110046947
Hyperprolactinaemia 40.95 9.79 92 505708 6483 110077016
Vitamin B1 decreased 40.64 9.79 34 505766 905 110082594
Thrombotic microangiopathy 40.55 9.79 44 505756 29105 110054394
Drug screen positive 40.27 9.79 90 505710 6320 110077179
Acute myocardial infarction 40.03 9.79 222 505578 83555 109999944
Aspergillus infection 39.88 9.79 35 505765 25581 110057918
Blood sodium decreased 39.82 9.79 306 505494 38013 110045486
Movement disorder 39.68 9.79 294 505506 36110 110047389
Cholestasis 39.67 9.79 156 505644 64362 110019137
Myelodysplastic syndrome 39.65 9.79 69 505731 37415 110046084
PO2 increased 39.61 9.79 42 505758 1517 110081982
Intentional product use issue 39.59 9.79 848 504952 247058 109836441
Sneezing 39.48 9.79 53 505747 31931 110051568
Drug dose omission by device 39.41 9.79 9 505791 14507 110068992
Visceral congestion 39.18 9.79 39 505761 1306 110082193
Drop attacks 39.10 9.79 36 505764 1092 110082407
Narcotic bowel syndrome 39.09 9.79 21 505779 258 110083241
Encephalitis autoimmune 38.95 9.79 63 505737 3465 110080034
Device issue 38.93 9.79 61 505739 34474 110049025
Generalised tonic-clonic seizure 38.92 9.79 402 505398 54278 110029221
Hyperkalaemia 38.80 9.79 415 505385 135381 109948118
Disturbance in attention 38.68 9.79 444 505356 61551 110021948
Psychiatric decompensation 38.55 9.79 83 505717 5682 110077817
Dystonic tremor 38.31 9.79 23 505777 354 110083145
Acute generalised exanthematous pustulosis 38.31 9.79 26 505774 21638 110061861
Musculoskeletal pain 38.16 9.79 1102 504698 181921 109901578
Paradoxical drug reaction 38.06 9.79 115 505685 9702 110073797
Dyspnoea exertional 37.98 9.79 299 505501 103761 109979738
Female genital tract fistula 37.96 9.79 14 505786 16505 110066994
BK virus infection 37.91 9.79 7 505793 13099 110070400
Panniculitis 37.89 9.79 12 505788 15570 110067929
Victim of sexual abuse 37.72 9.79 26 505774 513 110082986
H1N1 influenza 37.64 9.79 57 505743 2961 110080538
Relapsing-remitting multiple sclerosis 37.56 9.79 47 505753 2035 110081464
Enthesopathy 37.56 9.79 6 505794 12472 110071027
Blood osmolarity increased 37.54 9.79 31 505769 810 110082689
Infusion related reaction 37.50 9.79 1395 504405 379767 109703732
Skin haemorrhage 37.37 9.79 35 505765 24792 110058707
Inappropriate schedule of product administration 37.22 9.79 681 505119 202956 109880543
Liver injury 37.18 9.79 926 504874 149487 109934012
Gait disturbance 37.01 9.79 1591 504209 276617 109806882
Propofol infusion syndrome 36.79 9.79 52 505748 2537 110080962
Prescribed overdose 36.78 9.79 584 505216 86997 109996502
Nephropathy toxic 36.57 9.79 43 505757 27435 110056064
Depressed mood 36.38 9.79 432 505368 60377 110023122
Homicidal ideation 36.33 9.79 62 505738 3565 110079934
Anxiolytic therapy 36.22 9.79 13 505787 53 110083446
Drug therapy enhancement 36.22 9.79 13 505787 53 110083446
Arthritis 36.02 9.79 544 505256 167042 109916457
Pancytopenia 35.84 9.79 709 505091 208904 109874595
Muscle injury 35.44 9.79 869 504931 139938 109943561
Gout 35.42 9.79 71 505729 36495 110047004
Mood altered 35.36 9.79 192 505608 21183 110062316
Coronary artery disease 35.34 9.79 188 505612 71502 110011997
Neutropenia 35.32 9.79 1378 504422 373242 109710257
Vasculitis 35.31 9.79 69 505731 35804 110047695
Respiratory acidosis 35.31 9.79 141 505659 13685 110069814
Urinary retention 35.30 9.79 480 505320 69203 110014296
Dislocation of vertebra 35.30 9.79 330 505470 43391 110040108
Product use issue 35.23 9.79 1121 504679 310574 109772925
Epstein-Barr virus infection 35.17 9.79 21 505779 18717 110064782
Hypertonia 35.00 9.79 101 505699 8305 110075194
Parathyroid gland enlargement 34.92 9.79 18 505782 202 110083297
Schizoaffective disorder 34.62 9.79 56 505744 3080 110080419
Hyponatraemia 34.62 9.79 1269 504531 216384 109867115
Hyperthyroidism 34.61 9.79 50 505750 29211 110054288
Blood test abnormal 34.56 9.79 48 505752 28506 110054993
Product dose omission in error 34.39 9.79 34 505766 23478 110060021
Anger 34.38 9.79 175 505625 18832 110064667
Bronchopulmonary aspergillosis 34.38 9.79 52 505748 29811 110053688
Altered state of consciousness 34.31 9.79 409 505391 57217 110026282
Nasal congestion 34.22 9.79 286 505514 97996 109985503
Fear 34.19 9.79 202 505598 22991 110060508
Impaired driving ability 34.09 9.79 84 505716 6286 110077213
Herpes zoster 33.95 9.79 324 505476 108055 109975444
Decorticate posture 33.90 9.79 21 505779 343 110083156
Inappropriate antidiuretic hormone secretion 33.89 9.79 268 505532 33583 110049916
Drug-induced liver injury 33.88 9.79 368 505432 119699 109963800
Crying 33.87 9.79 217 505583 25411 110058088
Accidental exposure to product by child 33.81 9.79 56 505744 3142 110080357
Staring 33.79 9.79 53 505747 2839 110080660
Disease recurrence 33.65 9.79 153 505647 60631 110022868
Swelling 33.37 9.79 1290 504510 349751 109733748
Cardiac murmur 33.36 9.79 38 505762 24590 110058909
Blood pH decreased 33.28 9.79 69 505731 4600 110078899
Pulmonary alveolar haemorrhage 33.26 9.79 26 505774 20124 110063375
Cytomegalovirus viraemia 33.22 9.79 20 505780 17744 110065755
Cerebrovascular accident 33.20 9.79 606 505194 180678 109902821
Epidural lipomatosis 33.12 9.79 44 505756 2023 110081476
Injury 33.10 9.79 1053 504747 176212 109907287
Fibromyalgia 32.90 9.79 1019 504781 169890 109913609
Head injury 32.90 9.79 321 505479 42696 110040803
Proteinuria 32.84 9.79 85 505715 39933 110043566
Blood uric acid increased 32.82 9.79 30 505770 21499 110062000
Renal disorder 32.79 9.79 116 505684 49363 110034136
Blood cholesterol increased 32.78 9.79 1091 504709 183694 109899805
Synovitis 32.63 9.79 979 504821 273113 109810386
Polydipsia 32.62 9.79 93 505707 7595 110075904
Acute psychosis 32.43 9.79 71 505729 4916 110078583
Nasal polyps 32.40 9.79 10 505790 13190 110070309
Vaginal discharge 32.33 9.79 21 505779 17887 110065612
Vitamin B1 increased 32.30 9.79 16 505784 164 110083335
Chronic graft versus host disease 32.25 9.79 3 505797 9454 110074045
Memory impairment 32.23 9.79 1152 504648 195792 109887707
C-reactive protein 31.95 9.79 243 505557 30088 110053411
Lymphocyte count abnormal 31.95 9.79 47 505753 2379 110081120
Melaena 31.87 9.79 184 505616 68573 110014926
Bacterial infection 31.82 9.79 106 505694 45930 110037569
Chronic kidney disease 31.81 9.79 211 505589 76080 110007419
Shock haemorrhagic 31.80 9.79 47 505753 27200 110056299
Proctitis 31.73 9.79 19 505781 16908 110066591
Malignant catatonia 31.46 9.79 26 505774 680 110082819
Multiple-drug resistance 31.45 9.79 132 505668 13103 110070396
Appendicitis 31.40 9.79 51 505749 28413 110055086
Renal failure 31.16 9.79 793 505007 225781 109857718
Parkinsonian gait 31.07 9.79 31 505769 1041 110082458
Nodule 31.06 9.79 64 505736 32567 110050932
Impulsive behaviour 31.03 9.79 55 505745 3260 110080239
Clonus 30.92 9.79 99 505701 8617 110074882
Sepsis 30.87 9.79 1204 504596 326142 109757357
Drug abuser 30.73 9.79 73 505727 5336 110078163
Self-injurious ideation 30.72 9.79 64 505736 4282 110079217
Echolalia 30.38 9.79 23 505777 528 110082971
Creatinine renal clearance decreased 30.27 9.79 33 505767 21782 110061717
Emotional distress 30.17 9.79 326 505474 44521 110038978
Dehydration 30.05 9.79 1565 504235 277946 109805553
Drug resistance 29.97 9.79 144 505656 56230 110027269
Waxy flexibility 29.71 9.79 18 505782 282 110083217
Disinhibition 29.34 9.79 52 505748 3082 110080417
Temperature regulation disorder 29.25 9.79 11 505789 12815 110070684
Therapeutic response decreased 29.17 9.79 291 505509 96208 109987291
Testicular atrophy 28.95 9.79 20 505780 396 110083103
Hypophagia 28.95 9.79 368 505432 52258 110031241
CSF oligoclonal band present 28.93 9.79 21 505779 451 110083048
Failure to thrive 28.91 9.79 131 505669 13443 110070056
Nephrogenic diabetes insipidus 28.84 9.79 45 505755 2400 110081099
Nephrolithiasis 28.69 9.79 181 505619 66031 110017468
Monoparesis 28.68 9.79 64 505736 4489 110079010
Polyneuropathy 28.64 9.79 65 505735 31947 110051552
Soft tissue disorder 28.63 9.79 55 505745 3469 110080030
Joint range of motion decreased 28.62 9.79 745 505055 121087 109962412
Hyperphosphataemia 28.51 9.79 20 505780 16361 110067138
Apraxia 28.45 9.79 55 505745 3485 110080014
Gangrene 28.38 9.79 20 505780 16321 110067178
Rhinitis perennial 28.35 9.79 16 505784 218 110083281
Panic reaction 28.29 9.79 70 505730 5252 110078247
Neutrophil count increased 28.20 9.79 262 505538 34390 110049109
Retinitis 28.13 9.79 248 505552 32079 110051420
Arthropathy 28.11 9.79 1053 504747 286469 109797030
Septic shock 28.09 9.79 529 505271 156999 109926500
Dermatitis atopic 27.95 9.79 46 505754 25495 110058004
Breast cancer female 27.93 9.79 11 505789 12457 110071042
Accidental death 27.81 9.79 67 505733 4942 110078557
C-reactive protein increased 27.79 9.79 771 505029 217148 109866351
Balance disorder 27.74 9.79 714 505086 115846 109967653
Alcohol withdrawal syndrome 27.67 9.79 41 505759 2089 110081410
Menstrual disorder 27.65 9.79 65 505735 4719 110078780
Rhinorrhoea 27.64 9.79 318 505482 102348 109981151
Back injury 27.64 9.79 117 505683 47282 110036217
Gastric cancer 27.63 9.79 8 505792 11000 110072499
Transplant dysfunction 27.47 9.79 3 505797 8325 110075174
Respiratory tract infection 27.44 9.79 203 505597 71414 110012085
COVID-19 pneumonia 27.44 9.79 83 505717 37060 110046439
Diabetes insipidus 27.41 9.79 79 505721 6491 110077008
Bradycardia 27.28 9.79 917 504883 154600 109928899
Cerebral salt-wasting syndrome 27.21 9.79 17 505783 282 110083217
Skin reaction 27.17 9.79 34 505766 21110 110062389
Self-destructive behaviour 27.17 9.79 26 505774 829 110082670
Hypocalcaemia 27.15 9.79 181 505619 65185 110018314
Cognitive disorder 27.02 9.79 556 505244 86955 109996544
Pancreatic fibrosis 26.88 9.79 12 505788 95 110083404
Social avoidant behaviour 26.85 9.79 69 505731 5300 110078199
Tuberculosis 26.82 9.79 25 505775 17749 110065750
Sputum purulent 26.79 9.79 38 505762 1860 110081639
Forced expiratory volume 26.67 9.79 12 505788 97 110083402
Mitochondrial DNA mutation 26.53 9.79 20 505780 456 110083043
Accidental exposure to product 26.43 9.79 128 505672 49880 110033619
Feeling of body temperature change 26.40 9.79 75 505725 6113 110077386
Myocardial reperfusion injury 26.35 9.79 13 505787 132 110083367
Respiratory symptom 26.34 9.79 18 505782 14927 110068572
Pulmonary tuberculosis 26.18 9.79 5 505795 9134 110074365
Mucormycosis 26.18 9.79 8 505792 10620 110072879
Kidney transplant rejection 26.16 9.79 11 505789 11976 110071523
Change of bowel habit 26.09 9.79 47 505753 2822 110080677
Colorectal cancer 26.08 9.79 5 505795 9109 110074390
Injection site bruising 26.07 9.79 133 505667 51130 110032369
Lip swelling 26.02 9.79 131 505669 50536 110032963
Atrial fibrillation 25.92 9.79 826 504974 228816 109854683
Phagophobia 25.91 9.79 10 505790 52 110083447
Solar urticaria 25.86 9.79 12 505788 105 110083394
Eye pruritus 25.85 9.79 71 505729 32704 110050795
Breath sounds abnormal 25.76 9.79 48 505752 25356 110058143
Galactorrhoea 25.72 9.79 58 505742 4097 110079402
Product use in unapproved indication 25.55 9.79 1732 504068 445645 109637854
Pneumonia viral 25.52 9.79 110 505690 11047 110072452
Immune reconstitution inflammatory syndrome 25.47 9.79 22 505778 16204 110067295
Therapeutic product ineffective 25.41 9.79 44 505756 2560 110080939
Device malfunction 25.30 9.79 49 505751 25509 110057990
Osteonecrosis 25.21 9.79 75 505725 33666 110049833
Femur fracture 25.18 9.79 111 505689 44358 110039141
Visual acuity reduced 25.15 9.79 70 505730 32103 110051396
Neologism 25.00 9.79 7 505793 9 110083490
Peripheral swelling 24.98 9.79 1553 504247 402481 109681018
Burns second degree 24.97 9.79 3 505797 7730 110075769
Confabulation 24.93 9.79 20 505780 501 110082998
Rales 24.86 9.79 47 505753 24692 110058807
Feelings of worthlessness 24.79 9.79 21 505779 569 110082930
Infection 24.75 9.79 1379 504421 360821 109722678
Hypersexuality 24.71 9.79 37 505763 1903 110081596
Macular degeneration 24.66 9.79 38 505762 21621 110061878
Dysphemia 24.60 9.79 56 505744 3981 110079518
Partial seizures 24.52 9.79 110 505690 11239 110072260
Endophthalmitis 24.50 9.79 4 505796 8183 110075316
Pyrexia 24.46 9.79 3670 502130 894595 109188904
Cerebral infarction 24.42 9.79 138 505662 51700 110031799
PCO2 increased 24.18 9.79 37 505763 1940 110081559
Dermatitis exfoliative generalised 24.05 9.79 10 505790 10962 110072537
Hypogammaglobulinaemia 24.05 9.79 34 505766 20042 110063457
Back pain 24.00 9.79 1420 504380 369576 109713923
Upper respiratory fungal infection 23.93 9.79 18 505782 409 110083090
Pressure of speech 23.92 9.79 30 505770 1302 110082197
Blood creatinine increased 23.85 9.79 645 505155 182244 109901255
Atelectasis 23.84 9.79 265 505535 36447 110047052
Coma scale 23.81 9.79 10 505790 67 110083432
Dysphagia 23.80 9.79 893 504907 152707 109930792
Fall 23.75 9.79 3129 502671 600353 109483146
Sarcoidosis 23.75 9.79 14 505786 12565 110070934
Coronary artery stenosis 23.68 9.79 17 505783 13741 110069758
Iatrogenic injury 23.66 9.79 33 505767 1590 110081909
Anticholinergic syndrome 23.50 9.79 57 505743 4223 110079276
Unintentional medical device removal 23.31 9.79 6 505794 8917 110074582
Drug screen false positive 23.27 9.79 30 505770 1339 110082160
Infective pulmonary exacerbation of cystic fibrosis 23.22 9.79 20 505780 14751 110068748
Influenza 23.20 9.79 592 505208 168509 109914990
Rash maculo-papular 23.20 9.79 222 505578 74000 110009499
Rapid eye movements sleep abnormal 23.19 9.79 15 505785 265 110083234
Cytopenia 23.19 9.79 66 505734 30050 110053449
Soliloquy 23.19 9.79 26 505774 1001 110082498
Extensor plantar response 23.08 9.79 36 505764 1919 110081580
Exposure via skin contact 22.95 9.79 16 505784 13131 110070368
Diarrhoea 22.92 9.79 4733 501067 1134772 108948727
Oral discharge 22.90 9.79 15 505785 271 110083228
Ascites 22.88 9.79 293 505507 92515 109990984
Therapeutic response shortened 22.66 9.79 65 505735 29518 110053981
Leukocytosis 22.62 9.79 359 505441 53469 110030030
Diabetic ketoacidosis 22.61 9.79 107 505693 41951 110041548
Clumsiness 22.55 9.79 52 505748 3728 110079771
Antidepressant discontinuation syndrome 22.51 9.79 12 505788 145 110083354
Chronic sinusitis 22.38 9.79 51 505749 25033 110058466
Dry skin 22.26 9.79 352 505448 107301 109976198
Wrong technique in product usage process 22.20 9.79 274 505526 87074 109996425
Abdominal distension 22.19 9.79 620 505180 174483 109909016
Device use error 22.10 9.79 7 505793 9082 110074417
Muscle disorder 22.07 9.79 74 505726 6598 110076901
Muscle mass 21.97 9.79 18 505782 465 110083034
Loose associations 21.90 9.79 10 505790 84 110083415
Protein C increased 21.86 9.79 9 505791 57 110083442
Autonomic nervous system imbalance 21.75 9.79 67 505733 5713 110077786
Rheumatoid arthritis 21.72 9.79 1134 504666 298479 109785020
Erysipelas 21.69 9.79 17 505783 13141 110070358
Alcohol use 21.68 9.79 54 505746 4068 110079431
Glaucoma 21.57 9.79 44 505756 22473 110061026
Vasoconstriction 21.55 9.79 26 505774 1084 110082415
Plasma cell myeloma 21.49 9.79 406 505394 62530 110020969
Bronchitis 21.48 9.79 550 505250 156482 109927017
Drug use disorder 21.45 9.79 149 505651 17925 110065574
Haematuria traumatic 21.45 9.79 16 505784 359 110083140
Nephrotic syndrome 21.41 9.79 19 505781 13812 110069687
Fluid retention 21.35 9.79 303 505497 94004 109989495
Cardiac failure chronic 21.34 9.79 19 505781 13792 110069707
Wound infection 21.26 9.79 585 505215 95880 109987619
Swollen joint count increased 21.25 9.79 517 505283 83144 110000355
Device dislocation 21.23 9.79 74 505726 31630 110051869
Posturing 21.14 9.79 26 505774 1106 110082393
Grandiosity 21.09 9.79 19 505781 560 110082939
Inflammatory marker increased 21.08 9.79 21 505779 14448 110069051
Oculogyric crisis 21.00 9.79 51 505749 3781 110079718
Antipsychotic drug level above therapeutic 20.96 9.79 39 505761 2401 110081098
Restless legs syndrome 20.95 9.79 188 505612 24438 110059061
Generalised anxiety disorder 20.91 9.79 42 505758 2737 110080762
Polyarthritis 20.89 9.79 34 505766 18929 110064570
Sinus disorder 20.85 9.79 78 505722 32650 110050849
Myalgia 20.72 9.79 819 504981 221562 109861937
Tachyphrenia 20.67 9.79 38 505762 2318 110081181
Injection site rash 20.59 9.79 48 505752 23371 110060128
Haemoptysis 20.40 9.79 218 505582 71136 110012363
Foreign body aspiration 20.37 9.79 18 505782 517 110082982
Eye disorder 20.36 9.79 66 505734 28840 110054659
Bradypnoea 20.35 9.79 86 505714 8563 110074936
Cerebral atrophy 20.35 9.79 89 505711 8996 110074503
Morbid thoughts 20.30 9.79 23 505777 896 110082603
Impaired work ability 20.27 9.79 58 505742 26361 110057138
Sputum discoloured 20.25 9.79 63 505737 27882 110055617
Orgasmic sensation decreased 20.22 9.79 8 505792 45 110083454
Premature delivery 20.18 9.79 72 505728 30560 110052939
Oesophageal carcinoma 20.15 9.79 14 505786 11510 110071989
Hepatocellular carcinoma 20.11 9.79 10 505790 9870 110073629
Apallic syndrome 20.00 9.79 25 505775 1081 110082418
Sluggishness 19.99 9.79 78 505722 7489 110076010
Compartment syndrome 19.95 9.79 66 505734 5844 110077655
Drug screen negative 19.90 9.79 15 505785 342 110083157
Benzodiazepine drug level increased 19.84 9.79 13 505787 235 110083264
Diet refusal 19.72 9.79 22 505778 842 110082657
Skin toxicity 19.71 9.79 15 505785 11768 110071731
Drug clearance decreased 19.61 9.79 52 505748 4070 110079429
Diabetes mellitus 19.54 9.79 328 505472 99053 109984446
Cardiogenic shock 19.44 9.79 168 505632 57170 110026329
Lymphopenia 19.43 9.79 106 505694 40064 110043435
Neurosensory hypoacusis 19.42 9.79 13 505787 244 110083255
Bone density decreased 19.38 9.79 27 505773 16015 110067484
Gastric ulcer 19.32 9.79 105 505695 39722 110043777
Varicella zoster virus infection 19.31 9.79 3 505797 6365 110077134
Lung opacity 19.28 9.79 15 505785 11637 110071862
Therapy interrupted 19.20 9.79 141 505659 49681 110033818
Rhinitis 19.19 9.79 47 505753 22498 110061001
Macrocytosis 19.19 9.79 45 505755 3262 110080237
Echopraxia 19.13 9.79 8 505792 53 110083446
Food allergy 19.09 9.79 39 505761 19909 110063590
Cutaneous vasculitis 19.09 9.79 18 505782 12711 110070788
Diabetes mellitus inadequate control 18.94 9.79 71 505729 29704 110053795
Cardiovascular disorder 18.94 9.79 48 505752 22712 110060787
Surgery 18.85 9.79 111 505689 41172 110042327
Encephalopathy 18.85 9.79 495 505305 80560 110002939
Incorrect product administration duration 18.84 9.79 41 505759 20457 110063042
Ocular hyperaemia 18.82 9.79 104 505696 39182 110044317
Focal dyscognitive seizures 18.77 9.79 49 505751 3800 110079699
Product storage error 18.73 9.79 45 505755 21683 110061816
Granuloma 18.73 9.79 10 505790 9480 110074019
Maternal exposure timing unspecified 18.70 9.79 162 505638 20851 110062648
Uveitis 18.68 9.79 45 505755 21665 110061834
Bursitis 18.63 9.79 749 505051 129169 109954330
Rhesus antigen positive 18.54 9.79 10 505790 124 110083375
Contusion 18.52 9.79 1272 504528 232089 109851410
Immunosuppression 18.50 9.79 33 505767 17726 110065773
Pulmonary toxicity 18.47 9.79 33 505767 17713 110065786
Injection site warmth 18.44 9.79 32 505768 17373 110066126
Acute graft versus host disease 18.41 9.79 19 505781 12862 110070637
Illusion 18.41 9.79 33 505767 1974 110081525
Frustration tolerance decreased 18.40 9.79 84 505716 8647 110074852
Adenovirus infection 18.38 9.79 14 505786 10980 110072519
Hyperosmolar state 18.26 9.79 20 505780 750 110082749
Joint effusion 18.25 9.79 43 505757 20862 110062637
Forced expiratory volume decreased 18.21 9.79 20 505780 13156 110070343
Gallbladder disorder 18.13 9.79 161 505639 20868 110062631
Bundle branch block right 18.09 9.79 107 505693 12184 110071315
Tendonitis 18.06 9.79 60 505740 26023 110057476
Urine abnormality 18.06 9.79 86 505714 9010 110074489
Benign prostatic hyperplasia 18.01 9.79 35 505765 18199 110065300
Pseudomonas infection 17.99 9.79 66 505734 27787 110055712
Drug specific antibody present 17.99 9.79 8 505792 8426 110075073
Coronary artery bypass 17.97 9.79 3 505797 6039 110077460
Schizophreniform disorder 17.95 9.79 11 505789 176 110083323
Staphylococcal infection 17.92 9.79 219 505581 69725 110013774
Toxic skin eruption 17.91 9.79 65 505735 27450 110056049
Rash pruritic 17.90 9.79 328 505472 97741 109985758
Hangover 17.86 9.79 37 505763 2465 110081034
Premature ejaculation 17.85 9.79 8 505792 64 110083435
Arthritis bacterial 17.81 9.79 14 505786 10806 110072693
Sciatica 17.80 9.79 551 505249 91848 109991651
Torticollis 17.79 9.79 43 505757 3178 110080321
Adrenal insufficiency 17.79 9.79 117 505683 42273 110041226
Hepatitis B reactivation 17.78 9.79 6 505794 7478 110076021
Attention deficit hyperactivity disorder 17.78 9.79 53 505747 4438 110079061
Renal cancer 17.77 9.79 20 505780 13014 110070485
Walking aid user 17.68 9.79 184 505616 24891 110058608
Chest discomfort 17.58 9.79 634 505166 173214 109910285
Pneumonia cytomegaloviral 17.56 9.79 5 505795 6949 110076550
Overlap syndrome 17.51 9.79 85 505715 8974 110074525
Sickle cell anaemia with crisis 17.49 9.79 11 505789 9534 110073965
Breast cancer stage III 17.49 9.79 480 505320 78637 110004862
Device leakage 17.47 9.79 29 505771 16019 110067480
Conjunctivitis allergic 17.47 9.79 5 505795 6926 110076573
Neuritis 17.46 9.79 6 505794 7393 110076106
Torsade de pointes 17.46 9.79 169 505631 22431 110061068
Abortion spontaneous 17.40 9.79 89 505711 34193 110049306
Glycosylated haemoglobin increased 17.29 9.79 53 505747 23566 110059933
Posture abnormal 17.22 9.79 52 505748 4386 110079113
Hypernatraemia 17.20 9.79 140 505660 17693 110065806
Inappropriate affect 16.96 9.79 29 505771 1670 110081829
Anion gap increased 16.95 9.79 51 505749 4293 110079206
Haemoglobin urine 16.94 9.79 10 505790 149 110083350
Delirium tremens 16.93 9.79 19 505781 732 110082767
Respiratory tract congestion 16.88 9.79 78 505722 30779 110052720
Progressive multifocal leukoencephalopathy 16.88 9.79 58 505742 24898 110058601
Alcoholism 16.87 9.79 46 505754 3661 110079838
Brain abscess 16.86 9.79 5 505795 6769 110076730
Wrong drug 16.82 9.79 15 505785 436 110083063
Hypocholesterolaemia 16.81 9.79 66 505734 6355 110077144
Antidepressant drug level above therapeutic 16.81 9.79 19 505781 738 110082761
Blood lactic acid increased 16.81 9.79 127 505673 15694 110067805
Intraocular pressure increased 16.76 9.79 15 505785 10861 110072638
Thought insertion 16.66 9.79 7 505793 47 110083452
Gingival pain 16.61 9.79 29 505771 15707 110067792
Faecaloma 16.59 9.79 121 505679 14787 110068712
Aspiration 16.58 9.79 213 505587 30320 110053179
Blindness 16.48 9.79 98 505702 36261 110047238
Total lung capacity decreased 16.39 9.79 6 505794 7108 110076391
Arterial occlusive disease 16.35 9.79 28 505772 15280 110068219
Negative thoughts 16.31 9.79 28 505772 1618 110081881
Subarachnoid haemorrhage 16.30 9.79 75 505725 29627 110053872
Eyelid function disorder 16.29 9.79 16 505784 527 110082972
Water intoxication 16.27 9.79 21 505779 938 110082561
Skin disorder 16.27 9.79 122 505678 42791 110040708
Atrial tachycardia 16.25 9.79 11 505789 9167 110074332
Exostosis 16.23 9.79 298 505502 45658 110037841
Blunted affect 16.22 9.79 16 505784 530 110082969
Intellectual disability 16.22 9.79 31 505769 1948 110081551
Paraesthesia oral 16.20 9.79 89 505711 33582 110049917
Diaphragmatic rupture 16.18 9.79 11 505789 212 110083287
Pancreatitis acute 16.11 9.79 187 505613 60087 110023412
Regressive behaviour 16.09 9.79 11 505789 214 110083285
Cannabinoid hyperemesis syndrome 16.06 9.79 8 505792 83 110083416
Hyperuricaemia 16.06 9.79 26 505774 14505 110068994
Immunosuppressant drug level increased 15.98 9.79 18 505782 11706 110071793
Disease progression 15.95 9.79 933 504867 243101 109840398
Hyperthermia 15.91 9.79 158 505642 21114 110062385
Neglect of personal appearance 15.90 9.79 14 505786 400 110083099
Pruritus genital 15.90 9.79 5 505795 6517 110076982
Ventricular fibrillation 15.88 9.79 117 505683 41196 110042303
Graft versus host disease in skin 15.85 9.79 9 505791 8245 110075254
Dust allergy 15.74 9.79 4 505796 5997 110077502
White blood cell count increased 15.72 9.79 566 505234 96276 109987223
Pulmonary arterial hypertension 15.72 9.79 86 505714 32482 110051017
Pica 15.66 9.79 8 505792 88 110083411
Laryngeal injury 15.62 9.79 5 505795 13 110083486
Product preparation error 15.61 9.79 16 505784 10863 110072636
Selective mutism 15.58 9.79 8 505792 89 110083410
Electrocardiogram J wave 15.58 9.79 8 505792 89 110083410
Accidental overdose 15.57 9.79 328 505472 51506 110031993
Foot fracture 15.56 9.79 62 505738 25484 110058015
Dry mouth 15.54 9.79 1088 504712 198860 109884639
Perseveration 15.53 9.79 14 505786 413 110083086
Blood bicarbonate decreased 15.52 9.79 60 505740 5737 110077762
Differential white blood cell count abnormal 15.41 9.79 33 505767 2251 110081248
Immune thrombocytopenia 15.40 9.79 52 505748 22442 110061057
Talipes 15.35 9.79 10 505790 179 110083320
Dry eye 15.34 9.79 172 505628 55621 110027878
Palmoplantar keratoderma 15.32 9.79 3 505797 5384 110078115
Aortic valve stenosis 15.25 9.79 5 505795 6345 110077154
Asthma-chronic obstructive pulmonary disease overlap syndrome 15.22 9.79 5 505795 6339 110077160
Hypertonic bladder 15.12 9.79 56 505744 5246 110078253
Blood calcium increased 15.05 9.79 38 505762 18002 110065497
Procedural pain 15.01 9.79 98 505702 35467 110048032
Rectal polyp 15 9.79 26 505774 1514 110081985
Erythema multiforme 14.98 9.79 48 505752 21049 110062450
JC virus infection 14.93 9.79 3 505797 5287 110078212
Myopathy 14.93 9.79 61 505739 24899 110058600
Ischaemic stroke 14.85 9.79 119 505681 41144 110042355
Streptococcal sepsis 14.83 9.79 54 505746 5018 110078481
Hypercalcaemia 14.82 9.79 139 505661 46518 110036981
Acute coronary syndrome 14.78 9.79 55 505745 23057 110060442
Medication error 14.77 9.79 606 505194 104760 109978739
Libido decreased 14.74 9.79 60 505740 5875 110077624
Ductus arteriosus premature closure 14.70 9.79 8 505792 101 110083398
Self-medication 14.69 9.79 62 505738 6170 110077329
Rash macular 14.66 9.79 110 505690 38576 110044923
Dependence 14.62 9.79 36 505764 2693 110080806
Cerebral haemorrhage 14.61 9.79 209 505591 64759 110018740
Osteoarthritis 14.59 9.79 996 504804 181627 109901872
Immune-mediated enterocolitis 14.59 9.79 15 505785 10170 110073329
Sleep terror 14.53 9.79 6 505794 6604 110076895
Injection site haemorrhage 14.46 9.79 90 505710 32938 110050561
Somatic hallucination 14.45 9.79 7 505793 68 110083431
Erectile dysfunction 14.45 9.79 139 505661 18417 110065082
Self esteem decreased 14.38 9.79 21 505779 1056 110082443
Cerebral microhaemorrhage 14.36 9.79 14 505786 457 110083042
Cardiac failure acute 14.31 9.79 59 505741 24019 110059480
Cystitis haemorrhagic 14.30 9.79 21 505779 12188 110071311
Pancreatitis 14.30 9.79 543 505257 92990 109990509
Paralysis 14.26 9.79 121 505679 15479 110068020
Ulcer haemorrhage 14.24 9.79 162 505638 22409 110061090
Psychomotor skills impaired 14.21 9.79 67 505733 6991 110076508
Induced abortion failed 14.16 9.79 9 505791 154 110083345
Anaemia of malignant disease 14.14 9.79 20 505780 976 110082523
Enuresis 14.06 9.79 46 505754 4050 110079449
Illness 14.02 9.79 278 505522 81893 110001606
Daydreaming 14.01 9.79 22 505778 1180 110082319
Foot operation 14.00 9.79 8 505792 7305 110076194
Culture urine positive 13.97 9.79 51 505749 4745 110078754
Suspected suicide 13.96 9.79 118 505682 15081 110068418
Diverticulitis 13.94 9.79 167 505633 53355 110030144
Monocyte count decreased 13.90 9.79 44 505756 3807 110079692
Stereotypy 13.82 9.79 20 505780 997 110082502
Dermatitis exfoliative 13.81 9.79 19 505781 11328 110072171
Burning sensation 13.74 9.79 228 505572 68984 110014515
Swollen joint count 13.74 9.79 77 505723 8597 110074902
Nerve degeneration 13.73 9.79 11 505789 275 110083224
Purpura 13.73 9.79 61 505739 24327 110059172
Stent placement 13.73 9.79 8 505792 7226 110076273
Olfactory nerve disorder 13.72 9.79 6 505794 45 110083454
Drug level increased 13.70 9.79 300 505500 47419 110036080
Sexual dysfunction 13.69 9.79 76 505724 8454 110075045
Lymphoproliferative disorder 13.67 9.79 8 505792 7210 110076289
Nasal mucosal disorder 13.63 9.79 28 505772 1855 110081644
Shoshin beriberi 13.62 9.79 7 505793 78 110083421
Coronary arterial stent insertion 13.61 9.79 5 505795 5910 110077589
Small intestinal obstruction 13.60 9.79 215 505585 31998 110051501
Hepatocellular injury 13.58 9.79 157 505643 50485 110033014
Muscle tension dysphonia 13.53 9.79 11 505789 281 110083218
Metabolic syndrome 13.51 9.79 39 505761 3208 110080291
Scleritis 13.49 9.79 4 505796 5416 110078083
Mycobacterium avium complex infection 13.47 9.79 5 505795 5872 110077627
Feeling guilty 13.44 9.79 19 505781 927 110082572
Pneumonia bacterial 13.43 9.79 68 505732 26193 110057306
Morose 13.39 9.79 6 505794 48 110083451
Neck pain 13.38 9.79 445 505355 122685 109960814
Pulmonary pain 13.38 9.79 6 505794 6287 110077212
Suspected suicide attempt 13.37 9.79 12 505788 352 110083147
Cytomegalovirus chorioretinitis 13.36 9.79 8 505792 7120 110076379
Oxygen saturation abnormal 13.36 9.79 56 505744 5555 110077944
Anxiety disorder 13.36 9.79 52 505748 4988 110078511
Respiratory distress 13.34 9.79 411 505389 68463 110015036
Cardiac disorder 13.34 9.79 257 505543 76023 110007476
Blood gases abnormal 13.32 9.79 23 505777 1335 110082164
Decreased appetite 13.32 9.79 2421 503379 473425 109610074
Oral pain 13.29 9.79 243 505557 37201 110046298
Hypercapnia 13.25 9.79 92 505708 11067 110072432
Anhedonia 13.24 9.79 118 505682 15310 110068189
Myasthenia gravis 13.23 9.79 52 505748 21459 110062040
Post procedural infection 13.22 9.79 27 505773 13782 110069717
Blood phosphorus increased 13.19 9.79 35 505765 16305 110067194
Atypical femur fracture 13.11 9.79 6 505794 6213 110077286
Victim of crime 13.02 9.79 23 505777 1360 110082139
Immune-mediated myositis 12.99 9.79 6 505794 6180 110077319
Skin cancer 12.95 9.79 40 505760 17744 110065755
Muscle contracture 12.93 9.79 35 505765 2773 110080726
Dysphoria 12.92 9.79 61 505739 6367 110077132
Diverticulum intestinal 12.92 9.79 21 505779 11698 110071801
Hepatotoxicity 12.87 9.79 208 505592 63192 110020307
Pulseless electrical activity 12.79 9.79 125 505675 16632 110066867
Haemarthrosis 12.69 9.79 9 505791 7320 110076179
Systemic lupus erythematosus 12.67 9.79 996 504804 253342 109830157
Soft tissue swelling 12.65 9.79 26 505774 1723 110081776
Deafness 12.63 9.79 71 505729 26638 110056861
Skin swelling 12.63 9.79 11 505789 8069 110075430
Hypothyroidism 12.63 9.79 246 505554 72653 110010846
Platelet production decreased 12.60 9.79 4 505796 10 110083489
Abulia 12.57 9.79 22 505778 1291 110082208
Autoimmune haemolytic anaemia 12.55 9.79 18 505782 10549 110072950
Flight of ideas 12.51 9.79 17 505783 799 110082700
Duodenal ulcer haemorrhage 12.49 9.79 11 505789 8026 110075473
Metastases to peritoneum 12.48 9.79 5 505795 5605 110077894
Anuria 12.46 9.79 63 505737 24278 110059221
Rapid eye movement sleep behaviour disorder 12.46 9.79 15 505785 624 110082875
Therapy cessation 12.44 9.79 138 505662 44719 110038780
Growth hormone deficiency 12.39 9.79 13 505787 464 110083035
Vulvar basal cell carcinoma 12.37 9.79 5 505795 30 110083469
Electroconvulsive therapy 12.36 9.79 7 505793 96 110083403
Abdominal discomfort 12.34 9.79 1595 504205 392263 109691236
Injection site urticaria 12.34 9.79 39 505761 17176 110066323
Sexual relationship change 12.33 9.79 4 505796 11 110083488
Cystitis 12.32 9.79 220 505580 65816 110017683
Substance use 12.32 9.79 32 505768 2474 110081025
Varices oesophageal 12.31 9.79 9 505791 7206 110076293
Vitreous haemorrhage 12.27 9.79 3 505797 4617 110078882
Disseminated intravascular coagulation 12.27 9.79 125 505675 41161 110042338
Cholelithiasis 12.24 9.79 210 505590 63212 110020287
Streptococcal bacteraemia 12.23 9.79 48 505752 4621 110078878
Maximal voluntary ventilation abnormal 12.23 9.79 5 505795 31 110083468
Haemorrhage 12.21 9.79 383 505417 106309 109977190
Nail bed inflammation 12.19 9.79 28 505772 2002 110081497
Delusional perception 12.17 9.79 12 505788 397 110083102
Colitis microscopic 12.14 9.79 27 505773 13367 110070132
Retinal detachment 12.14 9.79 20 505780 11080 110072419
Hypervigilance 12.12 9.79 15 505785 642 110082857
Bipolar I disorder 12.10 9.79 30 505770 2253 110081246
B-cell lymphoma 12.10 9.79 9 505791 7145 110076354
Sacroiliitis 12.10 9.79 50 505750 4928 110078571
Pain in jaw 12.09 9.79 163 505637 51014 110032485
Tachypnoea 12.06 9.79 250 505550 39145 110044354
Spasmodic dysphonia 12.04 9.79 14 505786 561 110082938
Polydipsia psychogenic 12.02 9.79 11 505789 331 110083168
On and off phenomenon 12.01 9.79 46 505754 4378 110079121
Skin lesion 12.00 9.79 165 505635 51466 110032033
Panic disorder 12.00 9.79 39 505761 3422 110080077
Blood creatine phosphokinase 11.99 9.79 11 505789 332 110083167
Epistaxis 11.95 9.79 481 505319 129891 109953608
Radiation pneumonitis 11.95 9.79 3 505797 4533 110078966
Pregnancy 11.91 9.79 312 505488 50755 110032744
Cholinergic rebound syndrome 11.90 9.79 6 505794 64 110083435
Metabolic encephalopathy 11.87 9.79 89 505711 10971 110072528
Type 2 diabetes mellitus 11.85 9.79 953 504847 176279 109907220
Hostility 11.82 9.79 33 505767 2663 110080836
Irritable bowel syndrome 11.81 9.79 888 504912 163327 109920172
Cytomegalovirus colitis 11.80 9.79 9 505791 7052 110076447
Hepatitis B 11.79 9.79 16 505784 9596 110073903
Anti-neutrophil cytoplasmic antibody positive vasculitis 11.77 9.79 5 505795 5412 110078087
Post-injection delirium sedation syndrome 11.76 9.79 16 505784 753 110082746
Lymphocyte count decreased 11.74 9.79 344 505456 56899 110026600
Localised infection 11.72 9.79 133 505667 42915 110040584
Tangentiality 11.69 9.79 9 505791 212 110083287
Hallucination, olfactory 11.67 9.79 14 505786 580 110082919
Hemiplegia 11.64 9.79 59 505741 22723 110060776
Ovarian hyperstimulation syndrome 11.57 9.79 5 505795 5355 110078144
Cellulitis 11.54 9.79 465 505335 125551 109957948
Brain death 11.53 9.79 60 505740 6513 110076986
Nephropathy 11.52 9.79 28 505772 13439 110070060
Chest pain 11.52 9.79 1924 503876 374451 109709048
Hypervolaemia 11.52 9.79 158 505642 49302 110034197
Peritonitis bacterial 11.50 9.79 19 505781 10514 110072985
Osteoporotic fracture 11.48 9.79 5 505795 5332 110078167
Mitochondrial encephalomyopathy 11.48 9.79 7 505793 111 110083388
Toxicologic test abnormal 11.36 9.79 21 505779 1286 110082213
Pleurisy 11.33 9.79 24 505776 12092 110071407
Injection site discolouration 11.32 9.79 15 505785 9088 110074411
Faeces discoloured 11.27 9.79 100 505700 33848 110049651
Ventricular compliance decreased 11.27 9.79 5 505795 39 110083460
Endoscopic retrograde cholangiopancreatography 11.23 9.79 9 505791 225 110083274
Exercise tolerance decreased 11.21 9.79 24 505776 12043 110071456
Natural killer cell count 11.20 9.79 4 505796 16 110083483
Ketoacidosis 11.19 9.79 18 505782 10069 110073430
Gastrointestinal injury 11.16 9.79 26 505774 1877 110081622
Iron deficiency 11.15 9.79 45 505755 18431 110065068
Thought withdrawal 11.11 9.79 3 505797 3 110083496
Radiculopathy 11.11 9.79 48 505752 19288 110064211
Eosinophilic pneumonia 11.10 9.79 10 505790 7217 110076282
Cholinergic syndrome 11.08 9.79 21 505779 1311 110082188
Acute myeloid leukaemia 11.07 9.79 116 505684 37994 110045505
Hallucination, tactile 11.04 9.79 18 505782 997 110082502
Polymyalgia rheumatica 11.03 9.79 8 505792 6434 110077065
Dysmetropsia 11.01 9.79 7 505793 120 110083379
Meningitis cryptococcal 11.00 9.79 4 505796 4758 110078741
Type IV hypersensitivity reaction 10.99 9.79 7 505793 6026 110077473
Sedation complication 10.99 9.79 139 505661 19716 110063783
Moaning 10.96 9.79 22 505778 1433 110082066
Condition aggravated 10.96 9.79 3094 502706 731742 109351757
Skin laceration 10.93 9.79 216 505584 33537 110049962
Blood albumin increased 10.91 9.79 26 505774 1905 110081594
Wrong rate 10.90 9.79 8 505792 175 110083324
Aphasia 10.89 9.79 350 505450 58647 110024852
Lymphadenopathy 10.88 9.79 216 505584 63619 110019880
Type I hypersensitivity 10.87 9.79 8 505792 6385 110077114
Cardiac death 10.86 9.79 24 505776 1672 110081827
Subcutaneous drug absorption impaired 10.84 9.79 66 505734 7593 110075906
Bacterial test positive 10.82 9.79 68 505732 7909 110075590
Rabbit syndrome 10.82 9.79 11 505789 378 110083121
Decreased immune responsiveness 10.79 9.79 17 505783 9589 110073910
Exposure to toxic agent 10.79 9.79 27 505773 12831 110070668
Vulvovaginal burning sensation 10.77 9.79 27 505773 2042 110081457
Oropharyngeal swelling 10.76 9.79 22 505778 1452 110082047
Dissociative disorder 10.75 9.79 20 505780 1231 110082268
Nocardiosis 10.75 9.79 11 505789 7475 110076024
Paraphilia 10.74 9.79 6 505794 80 110083419
Emotional poverty 10.71 9.79 18 505782 1022 110082477
Middle insomnia 10.70 9.79 142 505658 20360 110063139
Abortion spontaneous complete 10.65 9.79 3 505797 4 110083495
Pneumoconiosis 10.63 9.79 10 505790 312 110083187
Anosmia 10.62 9.79 26 505774 12446 110071053
Pseudophaeochromocytoma 10.61 9.79 7 505793 128 110083371
Rhinitis allergic 10.60 9.79 44 505756 17878 110065621
Acute hepatic failure 10.59 9.79 111 505689 36357 110047142
Respiratory alkalosis 10.58 9.79 53 505747 5668 110077831
Lupus nephritis 10.57 9.79 4 505796 4641 110078858
Food refusal 10.54 9.79 17 505783 933 110082566
Squamous cell carcinoma 10.50 9.79 46 505754 18417 110065082
Affective ambivalence 10.49 9.79 4 505796 20 110083479
Brain oedema 10.41 9.79 200 505600 30898 110052601
Hypertensive crisis 10.37 9.79 67 505733 24305 110059194
Electrocardiogram abnormal 10.36 9.79 131 505669 18578 110064921
Mean cell haemoglobin increased 10.36 9.79 52 505748 5565 110077934
Hyperhidrosis 10.34 9.79 993 504807 186305 109897194
Amegakaryocytic thrombocytopenia 10.33 9.79 4 505796 21 110083478
Labelled drug-drug interaction medication error 10.32 9.79 85 505715 29217 110054282
Arthritis infective 10.32 9.79 20 505780 10409 110073090
Demyelination 10.30 9.79 17 505783 9412 110074087
Alpha haemolytic streptococcal infection 10.29 9.79 38 505762 3555 110079944
Food craving 10.28 9.79 26 505774 1977 110081522
Acute graft versus host disease in skin 10.28 9.79 21 505779 10719 110072780
Red blood cell sedimentation rate increased 10.24 9.79 276 505524 78026 110005473
Therapy non-responder 10.22 9.79 844 504956 156463 109927036
Anion gap decreased 10.22 9.79 16 505784 856 110082643
Vulvovaginal pruritus 10.19 9.79 36 505764 3295 110080204
Blood chloride decreased 10.15 9.79 74 505726 9041 110074458
Joint dislocation 10.15 9.79 216 505584 33974 110049525
Hypochloraemia 10.14 9.79 38 505762 3580 110079919
Colitis ischaemic 10.14 9.79 125 505675 17625 110065874
Obsessive thoughts 10.13 9.79 20 505780 1287 110082212
Vitamin D deficiency 10.09 9.79 47 505753 18505 110064994
Refusal of treatment by relative 10.08 9.79 15 505785 767 110082732
Migraine 10.07 9.79 914 504886 170738 109912761
Endotracheal intubation 10.04 9.79 55 505745 6089 110077410
Depressive delusion 10.04 9.79 4 505796 23 110083476
Carbohydrate antigen 125 increased 10.03 9.79 30 505770 2517 110080982
Inflammatory bowel disease 9.97 9.79 11 505789 7223 110076276
Discomfort 9.96 9.79 1125 504675 213582 109869917
Myocarditis 9.96 9.79 193 505607 29862 110053637
Delusional disorder, unspecified type 9.96 9.79 16 505784 875 110082624
Insurance issue 9.94 9.79 21 505779 10591 110072908
Labelled drug-food interaction medication error 9.92 9.79 8 505792 202 110083297
Gerstmann's syndrome 9.91 9.79 3 505797 6 110083493
Psychopathic personality 9.91 9.79 3 505797 6 110083493
Tension headache 9.91 9.79 18 505782 9600 110073899
Legal problem 9.90 9.79 7 505793 144 110083355
Morbihan disease 9.89 9.79 4 505796 24 110083475
Hyponatraemic syndrome 9.87 9.79 15 505785 782 110082717
Secondary immunodeficiency 9.86 9.79 45 505755 4631 110078868
Pulmonary mass 9.86 9.79 116 505684 37185 110046314
Anaphylactoid reaction 9.84 9.79 10 505790 6816 110076683
Breast cancer stage II 9.83 9.79 178 505622 27197 110056302
Hyperphagia 9.82 9.79 37 505763 3494 110080005
Incorrect dose administered by device 9.80 9.79 10 505790 6804 110076695
Fear of injection 9.80 9.79 16 505784 8895 110074604

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypotonia neonatal 40.93 26.29 34 505 891 112523
Nasal congestion 27.46 26.29 9 530 25 113389

Pharmacologic Action:

SourceCodeDescription
ATC N05BA06 NERVOUS SYSTEM
PSYCHOLEPTICS
ANXIOLYTICS
Benzodiazepine derivatives
ATC N05BA56 NERVOUS SYSTEM
PSYCHOLEPTICS
ANXIOLYTICS
Benzodiazepine derivatives
FDA CS M0002356 Benzodiazepines
MeSH PA D000927 Anticonvulsants
MeSH PA D000932 Antiemetics
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D006993 Hypnotics and Sedatives
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014151 Anti-Anxiety Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018682 GABA Agents
MeSH PA D018757 GABA Modulators
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35623 anticonvulsant
FDA EPC N0000175694 Benzodiazepine

Related Drugs by ATC class:

N05BA Benzodiazepine derivatives 23 drugs
adinazolamalprazolambentazepambromazepamcamazepamchlordiazepoxideclobazamclorazepateclotiazepamcloxazolamdiazepamethyl loflazepate show all 23 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Myoclonic seizure indication 37356005
Atonic seizure indication 42365007
Anxiety indication 48694002
Absence seizure indication 79631006
Lennox-Gastaut syndrome indication 230418006
Status epilepticus indication 230456007 DOID:1824
Panic disorder indication 371631005 DOID:594
Sedation as Adjunct to Anesthesia indication
Induce Anterograde Amnesia indication
Delirium off-label use 2776000
Alcohol withdrawal delirium off-label use 8635005
General anesthesia off-label use 50697003
Seizure disorder off-label use 128613002
Alcohol withdrawal syndrome off-label use 191480000
Insomnia off-label use 193462001
Spasticity off-label use 221360009
Chemotherapy-induced nausea and vomiting off-label use 236084000
Akathisia off-label use 285145004
Local anesthesia off-label use 386761002
Cocaine-Associated Acute Ischemic Heart Disease off-label use
Manic Bipolar Disorder Adjunct Treatment off-label use
Sedation in Intubated Patients off-label use
Suicidal thoughts contraindication 6471006
Hepatic encephalopathy contraindication 13920009 DOID:13413
Alcohol intoxication contraindication 25702006
Depressive disorder contraindication 35489007
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Substance abuse contraindication 66214007
Sleep apnea contraindication 73430006 DOID:0050847
Decreased respiratory function contraindication 80954004
Open-angle glaucoma contraindication 84494001 DOID:1067
Kidney disease contraindication 90708001 DOID:557
Hypoalbuminemia contraindication 119247004
Liver function tests abnormal contraindication 166603001
Disease of liver contraindication 235856003 DOID:409
Syncope contraindication 271594007
Pregnancy, function contraindication 289908002
Severe chronic obstructive pulmonary disease contraindication 313299006
At risk for aspiration contraindication 371736008
Angle-closure glaucoma contraindication 392291006 DOID:13550
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Central nervous system depression contraindication 418072004
Porphyria contraindication 418470004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.09 acidic
pKa2 11.41 acidic
pKa3 0.63 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
1.5MG LOREEV XR ALMATICA N214826 Feb. 16, 2022 RX CAPSULE, EXTENDED RELEASE ORAL 8999393 Jan. 8, 2034 ONCE DAILY TREATMENT OF ANXIETY DISORDER IN ADULTS
1MG LOREEV XR ALMATICA N214826 Aug. 27, 2021 RX CAPSULE, EXTENDED RELEASE ORAL 8999393 Jan. 8, 2034 ONCE DAILY TREATMENT OF ANXIETY DISORDER IN ADULTS
2MG LOREEV XR ALMATICA N214826 Aug. 27, 2021 RX CAPSULE, EXTENDED RELEASE ORAL 8999393 Jan. 8, 2034 ONCE DAILY TREATMENT OF ANXIETY DISORDER IN ADULTS
3MG LOREEV XR ALMATICA N214826 Aug. 27, 2021 RX CAPSULE, EXTENDED RELEASE ORAL 8999393 Jan. 8, 2034 ONCE DAILY TREATMENT OF ANXIETY DISORDER IN ADULTS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
GABA-A receptor alpha-1/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR IC50 8.46 WOMBAT-PK CHEMBL
Fatty acid-binding protein, liver Cytosolic other Ki 4.89 CHEMBL

External reference:

IDSource
4017848 VUID
N0000146205 NUI
D00365 KEGG_DRUG
4017848 VANDF
C0024002 UMLSCUI
CHEBI:6539 CHEBI
CHEMBL580 ChEMBL_ID
DB00186 DRUGBANK_ID
D008140 MESH_DESCRIPTOR_UI
3958 PUBCHEM_CID
5884 IUPHAR_LIGAND_ID
2809 INN_ID
O26FZP769L UNII
202479 RXNORM
2104 MMSL
3795 MMSL
4995 MMSL
d00149 MMSL
001460 NDDF
19225000 SNOMEDCT_US
387106007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0054-3532 SOLUTION, CONCENTRATE 2 mg ORAL ANDA 19 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-3425 TABLET 0.50 mg ORAL ANDA 21 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-3426 TABLET 1 mg ORAL ANDA 21 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-3427 TABLET 2 mg ORAL ANDA 21 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0121-0770 LIQUID 2 mg ORAL ANDA 21 sections
Ativan HUMAN PRESCRIPTION DRUG LABEL 1 0187-0063 TABLET 0.50 mg ORAL NDA 20 sections
Ativan HUMAN PRESCRIPTION DRUG LABEL 1 0187-0064 TABLET 1 mg ORAL NDA 20 sections
Ativan HUMAN PRESCRIPTION DRUG LABEL 1 0187-0065 TABLET 2 mg ORAL NDA 20 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0409-1539 INJECTION, SOLUTION 4 mg INTRAMUSCULAR ANDA 33 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0409-1985 INJECTION, SOLUTION 2 mg INTRAMUSCULAR ANDA 33 sections
Ativan HUMAN PRESCRIPTION DRUG LABEL 1 0641-6000 INJECTION 2 mg INTRAMUSCULAR NDA 25 sections
Ativan HUMAN PRESCRIPTION DRUG LABEL 1 0641-6001 INJECTION 2 mg INTRAMUSCULAR NDA 25 sections
Ativan HUMAN PRESCRIPTION DRUG LABEL 1 0641-6002 INJECTION 4 mg INTRAMUSCULAR NDA 25 sections
Ativan HUMAN PRESCRIPTION DRUG LABEL 1 0641-6003 INJECTION 4 mg INTRAMUSCULAR NDA 25 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0641-6044 INJECTION 2 mg INTRAMUSCULAR NDA 25 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0641-6045 INJECTION 4 mg INTRAMUSCULAR NDA 25 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0641-6046 INJECTION 2 mg INTRAMUSCULAR NDA 25 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0641-6047 INJECTION 4 mg INTRAMUSCULAR NDA 25 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0641-6048 INJECTION 2 mg INTRAMUSCULAR NDA 29 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0641-6049 INJECTION 4 mg INTRAMUSCULAR NDA 29 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0641-6050 INJECTION 2 mg INTRAMUSCULAR NDA 29 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0641-6051 INJECTION 4 mg INTRAMUSCULAR NDA 29 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0641-6207 INJECTION 2 mg INTRAMUSCULAR NDA 25 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0904-6007 TABLET 0.50 mg ORAL ANDA 24 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0904-6008 TABLET 1 mg ORAL ANDA 24 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0904-6009 TABLET 2 mg ORAL ANDA 24 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 10544-085 TABLET 1 mg ORAL ANDA 18 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 10544-244 TABLET 1 mg ORAL ANDA 18 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 10544-269 TABLET 1 mg ORAL ANDA 12 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 12634-867 TABLET 1 mg ORAL ANDA 10 sections