lorazepam Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diazepam derivatives 1606 846-49-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ativan
  • Wy 4036
  • Wy-4036
  • lorazepam
A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.
  • Molecular weight: 321.16
  • Formula: C15H10Cl2N2O2
  • CLOGP: 2.37
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 61.69
  • ALOGS: -4.26
  • ROTB: 1

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2.50 mg O
2.50 mg P
2.50 mg SL

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.08 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.44 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 93 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.09 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 17 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Sept. 30, 1977 FDA VALEANT INTL

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sopor 1579.64 9.59 1046 218133 18782 46448101
Drug abuse 1202.51 9.59 1485 217694 61923 46404960
Suicide attempt 479.99 9.59 898 218281 54138 46412745
Rheumatoid arthritis 424.15 9.59 306 218873 239909 46226974
Completed suicide 405.65 9.59 1554 217625 144366 46322517
Intentional self-injury 402.38 9.59 531 218648 23635 46443248
Intentional overdose 328.08 9.59 851 218328 64093 46402790
Agitation 319.78 9.59 764 218415 54651 46412232
Neuroleptic malignant syndrome 308.90 9.59 318 218861 10804 46456079
Somnolence 281.17 9.59 1464 217715 155057 46311826
Overdose 276.55 9.59 1078 218101 100901 46365982
Coma 251.14 9.59 721 218458 57628 46409255
Catatonia 250.97 9.59 178 219001 3584 46463299
Bradyphrenia 245.21 9.59 216 218963 6014 46460869
Anxiety 241.56 9.59 1571 217608 180386 46286497
Delirium 224.21 9.59 522 218657 36706 46430177
Drug ineffective 192.06 9.59 2149 217030 675689 45791194
Treatment failure 191.28 9.59 99 219080 92988 46373895
Contraindicated product administered 164.29 9.59 85 219094 79862 46387021
Confusional state 159.80 9.59 1290 217889 158602 46308281
Pemphigus 152.70 9.59 17 219162 45257 46421626
Toxicity to various agents 149.26 9.59 1585 217594 210181 46256702
Drug withdrawal syndrome 146.66 9.59 367 218812 27017 46439866
Poisoning 145.88 9.59 247 218932 13747 46453136
Drug intolerance 141.52 9.59 299 218880 146750 46320133
Systemic lupus erythematosus 128.51 9.59 73 219106 65107 46401776
Drug hypersensitivity 125.15 9.59 654 218525 243171 46223712
Serotonin syndrome 124.91 9.59 320 218859 23900 46442983
Psychotic disorder 124.12 9.59 306 218873 22315 46444568
Drug dependence 123.04 9.59 282 218897 19619 46447264
Suicidal ideation 122.29 9.59 557 218622 55825 46411058
Mania 116.46 9.59 194 218985 10652 46456231
Tachycardia 113.51 9.59 829 218350 98793 46368090
Arthralgia 104.65 9.59 1151 218028 363452 46103431
Pneumonia aspiration 103.16 9.59 355 218824 31250 46435633
Bradykinesia 102.26 9.59 109 219070 3857 46463026
Sedation 100.35 9.59 285 218894 22625 46444258
Therapeutic product effect decreased 96.40 9.59 149 219030 82452 46384431
Joint swelling 95.26 9.59 428 218751 165645 46301238
Hand deformity 94.42 9.59 23 219156 34551 46432332
Alopecia 94.10 9.59 417 218762 161997 46304886
Restlessness 92.48 9.59 297 218882 25227 46441656
Slow speech 92.05 9.59 65 219114 1299 46465584
Disorientation 91.73 9.59 380 218799 36538 46430345
Akathisia 91.01 9.59 144 219035 7570 46459313
Depressed level of consciousness 90.13 9.59 452 218727 47117 46419766
Extrapyramidal disorder 89.71 9.59 177 219002 11091 46455792
Drug interaction 87.87 9.59 1390 217789 201704 46265179
Hypothermia 87.06 9.59 183 218996 12000 46454883
Arthropathy 86.75 9.59 166 219013 84534 46382349
Injection site pain 84.86 9.59 241 218938 106911 46359972
Hypersensitivity 84.06 9.59 391 218788 149930 46316953
Mydriasis 81.88 9.59 164 219015 10389 46456494
Psoriasis 80.55 9.59 154 219025 78450 46388433
Device expulsion 79.90 9.59 16 219163 27526 46439357
Mental status changes 77.22 9.59 369 218810 37719 46429164
Maternal exposure during pregnancy 76.61 9.59 237 218942 102312 46364571
Rheumatoid factor positive 73.44 9.59 6 219173 20455 46446428
Dysarthria 72.94 9.59 359 218820 37139 46429744
Pneumonia viral 71.81 9.59 119 219060 6505 46460378
Respiratory depression 71.28 9.59 164 219015 11436 46455447
Aggression 71.21 9.59 252 218927 22492 46444391
Anti-cyclic citrullinated peptide antibody positive 70.45 9.59 5 219174 19140 46447743
Withdrawal syndrome 70.28 9.59 216 218963 17918 46448965
Psychomotor hyperactivity 67.07 9.59 143 219036 9470 46457413
Muscle rigidity 67.01 9.59 146 219033 9815 46457068
Delusion 66.37 9.59 156 219023 11032 46455851
Swelling 66.02 9.59 330 218849 124181 46342702
Soft tissue disorder 65.09 9.59 89 219090 4097 46462786
Hallucination, auditory 62.74 9.59 149 219030 10607 46456276
Mobility decreased 62.70 9.59 118 219061 60476 46406407
Injection site erythema 62.21 9.59 163 219016 74264 46392619
Glossodynia 62.02 9.59 70 219109 44303 46422580
Bezoar 61.52 9.59 52 219127 1367 46465516
Speech disorder 60.48 9.59 332 218847 35835 46431048
Rash 60.14 9.59 1247 217932 355265 46111618
Abnormal behaviour 59.76 9.59 226 218953 20832 46446051
Tardive dyskinesia 59.46 9.59 118 219061 7425 46459458
Abdominal discomfort 59.03 9.59 441 218738 150724 46316159
Pain 58.36 9.59 1750 217429 475198 45991685
Off label use 58.21 9.59 1349 217830 378492 46088391
Salivary hypersecretion 57.16 9.59 106 219073 6339 46460544
Seizure 55.35 9.59 848 218331 122206 46344677
Respiratory arrest 54.27 9.59 307 218872 33509 46433374
Electrocardiogram QRS complex prolonged 53.93 9.59 94 219085 5355 46461528
Psoriatic arthropathy 53.50 9.59 55 219124 36324 46430559
Depression 52.98 9.59 1106 218073 168998 46297885
Insomnia 52.90 9.59 1077 218102 163847 46303036
Status epilepticus 52.77 9.59 165 219014 13814 46453069
Unresponsive to stimuli 51.57 9.59 292 218887 31882 46435001
Tremor 51.27 9.59 795 218384 114844 46352039
Therapeutic product effect incomplete 49.99 9.59 193 218986 77960 46388923
Lower respiratory tract infection 49.67 9.59 116 219063 54973 46411910
Paranoia 49.53 9.59 135 219044 10462 46456421
Electrocardiogram QT prolonged 46.84 9.59 406 218773 50919 46415964
Interstitial lung disease 46.74 9.59 116 219063 53833 46413050
Narcotic bowel syndrome 46.66 9.59 19 219160 113 46466770
Diabetes insipidus 46.17 9.59 54 219125 2120 46464763
Abortion spontaneous 45.15 9.59 85 219094 43561 46423322
Psychomotor retardation 44.73 9.59 65 219114 3168 46463715
Hyponatraemia 44.67 9.59 696 218483 100636 46366247
Hallucination 44.48 9.59 393 218786 49558 46417325
Incontinence 44.47 9.59 124 219055 9738 46457145
Hip arthroplasty 44.02 9.59 15 219164 18097 46448786
Synovitis 43.60 9.59 144 219035 60931 46405952
Mutism 43.20 9.59 41 219138 1259 46465624
Schizophrenia 42.93 9.59 112 219067 8456 46458427
Infusion related reaction 42.04 9.59 290 218889 100918 46365965
Sinusitis 41.89 9.59 398 218781 129370 46337513
C-reactive protein abnormal 41.65 9.59 24 219155 21246 46445637
Injection site reaction 41.36 9.59 103 219076 47746 46419137
Asthma 41.21 9.59 256 218923 91286 46375597
Headache 40.89 9.59 1833 217346 476519 45990364
Dystonia 40.78 9.59 131 219048 11126 46455757
Tachypnoea 40.70 9.59 154 219025 14197 46452686
Urticaria 40.03 9.59 357 218822 117535 46349348
Nasopharyngitis 39.83 9.59 497 218682 153501 46313382
Somatic symptom disorder 39.79 9.59 47 219132 1865 46465018
Alcohol interaction 39.56 9.59 53 219126 2392 46464491
Pruritus 39.24 9.59 853 218326 241499 46225384
Injection site pruritus 38.86 9.59 80 219099 39663 46427220
Therapeutic response decreased 38.77 9.59 91 219088 43054 46423829
Cardiac arrest 38.74 9.59 618 218561 89781 46377102
Hypokinesia 38.54 9.59 129 219050 11193 46455690
Dehydration 36.72 9.59 995 218184 158545 46308338
Stupor 36.51 9.59 62 219117 3458 46463425
Myocardial depression 36.13 9.59 25 219154 483 46466400
Disorganised speech 35.89 9.59 31 219148 840 46466043
Injection site swelling 35.49 9.59 86 219093 40241 46426642
Gastric pH decreased 35.48 9.59 22 219157 350 46466533
Constipation 35.43 9.59 1069 218110 173028 46293855
Drooling 35.26 9.59 58 219121 3151 46463732
Parkinsonism 34.92 9.59 99 219080 7849 46459034
Toxic epidermal necrolysis 34.70 9.59 32 219147 22246 46444637
Knee arthroplasty 34.55 9.59 36 219143 23629 46443254
Mental disorder 34.28 9.59 201 218978 22224 46444659
Anaphylactic shock 34.17 9.59 27 219152 20247 46446636
Pain in extremity 34.08 9.59 939 218240 257741 46209142
Derealisation 33.94 9.59 29 219150 774 46466109
Product dose omission issue 33.74 9.59 572 218607 167948 46298935
Small intestinal obstruction 33.73 9.59 158 219021 16014 46450869
Sinus tachycardia 33.72 9.59 195 218984 21454 46445429
Hepatic enzyme increased 33.64 9.59 235 218944 81552 46385331
Fall 33.61 9.59 1877 217302 327220 46139663
Decorticate posture 33.61 9.59 21 219158 339 46466544
Encephalopathy 33.46 9.59 271 218908 33318 46433565
Cytomegalovirus infection 33.41 9.59 22 219157 18122 46448761
Persecutory delusion 33.38 9.59 50 219129 2505 46464378
Loss of consciousness 31.81 9.59 698 218481 107540 46359343
Exposure during pregnancy 31.55 9.59 340 218839 107872 46359011
Hepatic function abnormal 31.41 9.59 72 219107 34349 46432534
Infection 31.30 9.59 440 218739 133152 46333731
Malaise 31.22 9.59 1255 217924 329977 46136906
Red blood cell sedimentation rate increased 31.02 9.59 37 219142 22852 46444031
Drug use disorder 30.82 9.59 50 219129 2685 46464198
Hypoxia 30.54 9.59 375 218804 51463 46415420
Erythema 30.49 9.59 479 218700 142341 46324542
Miosis 30.31 9.59 84 219095 6573 46460310
Blister 29.98 9.59 108 219071 44523 46422360
Coma scale abnormal 29.91 9.59 70 219109 4936 46461947
Substance abuse 29.08 9.59 62 219117 4105 46462778
Injection site bruising 29.04 9.59 79 219100 35557 46431326
Bone erosion 28.43 9.59 5 219174 9438 46457445
Brain injury 28.40 9.59 78 219101 6072 46460811
Blood prolactin increased 28.38 9.59 51 219128 2976 46463907
Blood pH decreased 28.22 9.59 47 219132 2580 46464303
Panic attack 28.13 9.59 177 219002 20065 46446818
Renal ischaemia 28.01 9.59 23 219156 580 46466303
Hyperammonaemic encephalopathy 27.64 9.59 40 219139 1942 46464941
Crying 27.62 9.59 182 218997 20959 46445924
Cardiac failure 27.61 9.59 241 218938 79707 46387176
Pancreatic fibrosis 27.60 9.59 12 219167 86 46466797
Mood swings 27.04 9.59 149 219030 16103 46450780
Inflammation 26.57 9.59 128 219051 48653 46418230
Hallucinations, mixed 26.56 9.59 57 219122 3792 46463091
Product use issue 26.54 9.59 300 218879 94344 46372539
Granulocytopenia 26.49 9.59 69 219110 5204 46461679
Obsessive-compulsive disorder 26.19 9.59 51 219128 3164 46463719
Febrile neutropenia 26.16 9.59 605 218574 94022 46372861
Feeling of despair 26.01 9.59 37 219142 1768 46465115
Musculoskeletal stiffness 25.79 9.59 315 218864 97678 46369205
Mouth ulceration 25.40 9.59 55 219124 26777 46440106
Hallucination, visual 25.28 9.59 157 219022 17716 46449167
Major depression 25.28 9.59 79 219100 6611 46460272
C-reactive protein increased 25.26 9.59 166 219013 58424 46408459
Skin necrosis 24.95 9.59 5 219174 8599 46458284
Dyskinesia 24.94 9.59 226 218953 28699 46438184
Renal impairment 24.89 9.59 226 218953 74146 46392737
PCO2 increased 24.74 9.59 30 219149 1224 46465659
Peripheral swelling 24.51 9.59 560 218619 157511 46309372
Macrocytosis 24.46 9.59 41 219138 2262 46464621
Dysphagia 24.46 9.59 504 218675 76808 46390075
Cardio-respiratory arrest 24.41 9.59 406 218773 59463 46407420
Aspiration 24.37 9.59 99 219080 9432 46457451
Respiratory failure 24.32 9.59 600 218579 94216 46372667
No adverse event 24.23 9.59 81 219098 34150 46432733
Accidental exposure to product by child 24.03 9.59 28 219151 1095 46465788
PO2 increased 23.90 9.59 25 219154 865 46466018
Medication error 23.90 9.59 236 218943 30675 46436208
Hyperreflexia 23.63 9.59 66 219113 5188 46461695
Skin ulcer 23.53 9.59 76 219103 32382 46434501
Bradypnoea 23.30 9.59 47 219132 2992 46463891
Generalised tonic-clonic seizure 22.92 9.59 211 218968 26911 46439972
Bipolar disorder 22.88 9.59 80 219099 7097 46459786
Computerised tomogram thorax abnormal 22.79 9.59 30 219149 1331 46465552
Wrong patient received product 22.70 9.59 34 219145 1703 46465180
Coma scale 22.61 9.59 9 219170 50 46466833
Oral pain 22.54 9.59 196 218983 24601 46442282
Pneumocystis jirovecii pneumonia 22.48 9.59 23 219156 15225 46451658
Sleep disorder 22.38 9.59 326 218853 46469 46420414
Psychiatric decompensation 22.38 9.59 27 219152 1096 46465787
Sacroiliitis 22.23 9.59 38 219141 2131 46464752
Hepatocellular injury 22.19 9.59 68 219111 29454 46437429
Angioedema 22.15 9.59 102 219077 39240 46427643
Hypochloraemia 22.14 9.59 35 219144 1838 46465045
Pulseless electrical activity 22.08 9.59 79 219100 7088 46459795
Morbid thoughts 21.74 9.59 19 219160 523 46466360
Fibromyalgia 21.14 9.59 263 218916 36200 46430683
Osteoarthritis 20.96 9.59 188 218991 61837 46405046
Cataract 20.95 9.59 126 219053 45289 46421594
Drug reaction with eosinophilia and systemic symptoms 20.85 9.59 70 219109 29478 46437405
Condition aggravated 20.85 9.59 939 218240 244113 46222770
Electroencephalogram abnormal 20.82 9.59 51 219128 3703 46463180
Poisoning deliberate 20.80 9.59 83 219096 7843 46459040
Wrong drug 20.80 9.59 11 219168 127 46466756
Drug eruption 20.79 9.59 43 219136 21286 46445597
Dissociation 20.72 9.59 34 219145 1843 46465040
Skin maceration 20.62 9.59 8 219171 41 46466842
Acute psychosis 20.55 9.59 35 219144 1957 46464926
Myocardial fibrosis 20.52 9.59 19 219160 565 46466318
Solar urticaria 20.47 9.59 8 219171 42 46466841
Homicidal ideation 20.38 9.59 33 219146 1769 46465114
Communication disorder 20.32 9.59 39 219140 2394 46464489
Femur fracture 20.20 9.59 97 219082 36900 46429983
Withdrawal catatonia 20.16 9.59 8 219171 44 46466839
Cardiac failure congestive 20.15 9.59 306 218873 91444 46375439
Cognitive disorder 20.10 9.59 263 218916 36620 46430263
Rapid eye movements sleep abnormal 20.07 9.59 10 219169 101 46466782
Pregnancy 20.05 9.59 63 219116 27074 46439809
Tremor neonatal 19.98 9.59 10 219169 102 46466781
Respiratory distress 19.72 9.59 233 218946 31683 46435200
Depersonalisation/derealisation disorder 19.66 9.59 24 219155 986 46465897
Cerebral microhaemorrhage 19.65 9.59 10 219169 106 46466777
Cough 19.64 9.59 882 218297 229367 46237516
Myoclonus 19.63 9.59 125 219054 14227 46452656
Patient uncooperative 19.47 9.59 11 219168 146 46466737
Antipsychotic drug level increased 19.47 9.59 45 219134 3147 46463736
Psychomotor skills impaired 19.44 9.59 36 219143 2150 46464733
Galactorrhoea 19.40 9.59 50 219129 3747 46463136
Cogwheel rigidity 19.24 9.59 29 219150 1461 46465422
Neurosensory hypoacusis 19.19 9.59 14 219165 295 46466588
Peritonitis 19.16 9.59 43 219136 20671 46446212
Ventricular hypokinesia 19.11 9.59 52 219127 4026 46462857
Blood bicarbonate decreased 19.08 9.59 42 219137 2843 46464040
Mitochondrial encephalomyopathy 19.04 9.59 6 219173 14 46466869
Acute kidney injury 19.01 9.59 909 218270 234946 46231937
Accidental overdose 18.97 9.59 160 219019 19906 46446977
Suicidal behaviour 18.94 9.59 38 219141 2410 46464473
Atelectasis 18.93 9.59 152 219027 18638 46448245
Device issue 18.88 9.59 41 219138 19939 46446944
Multiple-drug resistance 18.88 9.59 39 219140 2526 46464357
Wheezing 18.84 9.59 160 219019 53226 46413657
Premature delivery 18.68 9.59 48 219131 22021 46444862
Homicide 18.63 9.59 16 219163 430 46466453
Failure to thrive 18.48 9.59 71 219108 6593 46460290
Screaming 18.39 9.59 44 219135 3147 46463736
Anaphylactic reaction 18.38 9.59 160 219019 52952 46413931
Schizophreniform disorder 18.20 9.59 8 219171 59 46466824
Haematotoxicity 18.18 9.59 5 219174 6928 46459955
Therapy cessation 18.17 9.59 64 219115 26565 46440318
Pericarditis 18.06 9.59 55 219124 23872 46443011
Uveitis 18.02 9.59 9 219170 8632 46458251
Lethargy 18.00 9.59 339 218840 50832 46416051
Tracheal atresia 17.96 9.59 6 219173 18 46466865
Neonatal behavioural syndrome 17.87 9.59 7 219172 37 46466846
Parosmia 17.82 9.59 51 219128 4065 46462818
Urinary retention 17.79 9.59 194 218985 25867 46441016
Anxiety disorder 17.70 9.59 46 219133 3465 46463418
Hypophagia 17.69 9.59 213 218966 29093 46437790
Victim of sexual abuse 17.67 9.59 17 219162 531 46466352
COVID-19 17.65 9.59 38 219141 18537 46448346
Encephalitis autoimmune 17.63 9.59 24 219155 1100 46465783
Mood altered 17.62 9.59 113 219066 12894 46453989
Red blood cell sedimentation rate abnormal 17.52 9.59 23 219156 13626 46453257
Respiratory acidosis 17.45 9.59 66 219113 6082 46460801
Drop attacks 17.38 9.59 19 219160 692 46466191
Loss of personal independence in daily activities 17.34 9.59 178 219001 57005 46409878
Nightmare 17.12 9.59 135 219044 16463 46450420
Feeling jittery 17.04 9.59 99 219080 10909 46455974
Basal cell carcinoma 17.01 9.59 45 219134 20442 46446441
Persistent left superior vena cava 17.00 9.59 7 219172 43 46466840
Delusion of grandeur 16.99 9.59 10 219169 144 46466739
Haemophagocytic lymphohistiocytosis 16.93 9.59 9 219170 8333 46458550
Tuberculosis 16.89 9.59 14 219165 10251 46456632
Change of bowel habit 16.85 9.59 30 219149 1738 46465145
Adverse event 16.76 9.59 93 219086 34091 46432792
Breast cancer 16.71 9.59 135 219044 45383 46421500
Depressed mood 16.68 9.59 234 218945 33085 46433798
Compartment syndrome 16.64 9.59 32 219147 1967 46464916
Ear infection 16.60 9.59 54 219125 22959 46443924
Intentional product use issue 16.54 9.59 163 219016 52617 46414266
Acute generalised exanthematous pustulosis 16.52 9.59 12 219167 9393 46457490
Rhesus antigen positive 16.50 9.59 9 219170 111 46466772
Hyperprolactinaemia 16.44 9.59 40 219139 2892 46463991
Liver disorder 16.32 9.59 105 219074 37141 46429742
Infective pulmonary exacerbation of cystic fibrosis 16.27 9.59 16 219163 10791 46456092
Inappropriate affect 16.23 9.59 20 219159 830 46466053
Osteonecrosis of jaw 16.10 9.59 95 219084 34307 46432576
Refusal of treatment by patient 16.10 9.59 59 219120 5356 46461527
Pallor 16.07 9.59 173 219006 22993 46443890
Osteoporosis 16.05 9.59 118 219061 40490 46426393
Hyperchloraemia 16.05 9.59 18 219161 675 46466208
Atonic seizures 15.91 9.59 17 219162 603 46466280
Behaviour disorder 15.84 9.59 31 219148 1930 46464953
Suspected suicide attempt 15.83 9.59 9 219170 121 46466762
Diaphragmatic rupture 15.79 9.59 11 219168 215 46466668
Device difficult to use 15.72 9.59 9 219170 7995 46458888
Central nervous system necrosis 15.70 9.59 9 219170 123 46466760
Autonomic nervous system imbalance 15.68 9.59 35 219144 2391 46464492
Hypotonia neonatal 15.67 9.59 20 219159 860 46466023
Schizoaffective disorder 15.62 9.59 26 219153 1426 46465457
Newborn persistent pulmonary hypertension 15.62 9.59 8 219171 86 46466797
Inappropriate schedule of product administration 15.61 9.59 213 218966 64800 46402083
Hypervigilance 15.60 9.59 13 219166 335 46466548
Cardiac malposition 15.55 9.59 7 219172 55 46466828
Alcohol use 15.53 9.59 35 219144 2407 46464476
Apnoea 15.52 9.59 72 219107 7267 46459616
Leukocytosis 15.43 9.59 173 219006 23225 46443658
Anomalous pulmonary venous connection 15.34 9.59 7 219172 57 46466826
Echolalia 15.30 9.59 10 219169 175 46466708
Gastric ulcer 15.29 9.59 52 219127 21811 46445072
Platelet production decreased 15.24 9.59 4 219175 3 46466880
Blood creatine phosphokinase increased 15.23 9.59 198 218981 27526 46439357
Respiratory alkalosis 15.23 9.59 36 219143 2555 46464328
Lung disorder 15.18 9.59 130 219049 43174 46423709
Visceral congestion 15.15 9.59 12 219167 287 46466596
Device dislocation 15.15 9.59 52 219127 21750 46445133
Morose 14.83 9.59 6 219173 35 46466848
Glaucoma 14.77 9.59 33 219146 15888 46450995
Squamous cell carcinoma of the oral cavity 14.70 9.59 12 219167 300 46466583
Device use error 14.64 9.59 3 219176 5078 46461805
Skin reaction 14.51 9.59 18 219161 10928 46455955
Intentional product misuse 14.50 9.59 306 218873 46822 46420061
Blood creatine increased 14.49 9.59 51 219128 4539 46462344
Aphasia 14.45 9.59 201 218978 28366 46438517
Impaired healing 14.41 9.59 107 219072 36636 46430247
Bone marrow failure 14.39 9.59 81 219098 29588 46437295
Tooth hypoplasia 14.37 9.59 7 219172 67 46466816
Thymus disorder 14.33 9.59 10 219169 196 46466687
Prescribed overdose 14.29 9.59 91 219088 10358 46456525
Hypotension 14.17 9.59 1272 217907 231317 46235566
Oppositional defiant disorder 14.16 9.59 6 219173 40 46466843
Bronchitis 14.10 9.59 384 218795 105595 46361288
Oxygen saturation abnormal 14.10 9.59 36 219143 2682 46464201
Pleurothotonus 14.09 9.59 22 219157 1143 46465740
Staring 14.08 9.59 25 219154 1445 46465438
Disturbance in attention 13.98 9.59 217 218962 31343 46435540
Psychotic behaviour 13.97 9.59 16 219163 614 46466269
Affective disorder 13.93 9.59 52 219127 4763 46462120
Wound 13.91 9.59 131 219048 42671 46424212
H1N1 influenza 13.91 9.59 25 219154 1459 46465424
Alcohol poisoning 13.86 9.59 32 219147 2236 46464647
Ductus arteriosus premature closure 13.80 9.59 12 219167 328 46466555
Renal failure 13.75 9.59 417 218762 113177 46353706
Neutropenic sepsis 13.64 9.59 23 219156 12301 46454582
Oedema 13.61 9.59 227 218952 66844 46400039
Wound infection fungal 13.61 9.59 7 219172 76 46466807
Upper respiratory tract infection 13.60 9.59 213 218966 63343 46403540
Irritability 13.58 9.59 201 218978 28745 46438138
Foot deformity 13.48 9.59 33 219146 15392 46451491
Melaena 13.37 9.59 76 219103 27696 46439187
Protein C increased 13.37 9.59 9 219170 166 46466717
Product complaint 13.36 9.59 100 219079 12001 46454882
Vasoconstriction 13.35 9.59 14 219165 486 46466397
Pressure of speech 13.32 9.59 15 219164 565 46466318
Left ventricle outflow tract obstruction 13.26 9.59 10 219169 222 46466661
Cardiovascular disorder 13.26 9.59 23 219156 12164 46454719
Transient aphasia 13.24 9.59 6 219173 48 46466835
Mental impairment 13.23 9.59 102 219077 12354 46454529
Injection site warmth 13.23 9.59 28 219151 13744 46453139
Neutrophil Pelger-Huet anomaly present 13.22 9.59 7 219172 81 46466802
Emotional distress 13.17 9.59 210 218969 30497 46436386
Disease progression 13.15 9.59 539 218640 90761 46376122
Electrocardiogram T wave abnormal 13.15 9.59 32 219147 2314 46464569
Ataxia 13.13 9.59 111 219068 13819 46453064
Anger 13.12 9.59 98 219081 11754 46455129
Reaction to azo-dyes 13.10 9.59 3 219176 0 46466883
Antidepressant drug level below therapeutic 13.10 9.59 3 219176 0 46466883
Febrile bone marrow aplasia 13.07 9.59 8 219171 6854 46460029
Loss of libido 13.00 9.59 23 219156 1326 46465557
Urinary incontinence 12.95 9.59 197 218982 28333 46438550
Toxic skin eruption 12.92 9.59 24 219155 12363 46454520
Gastrointestinal sounds abnormal 12.88 9.59 41 219138 3465 46463418
Gastrointestinal haemorrhage 12.87 9.59 271 218908 77102 46389781
Phagophobia 12.83 9.59 5 219174 26 46466857
Cerebellar haematoma 12.82 9.59 12 219167 362 46466521
Wrong technique in product usage process 12.82 9.59 179 219000 54243 46412640
Peritonitis bacterial 12.81 9.59 13 219166 8640 46458243
Congenital pneumonia 12.79 9.59 4 219175 9 46466874
Surgery 12.69 9.59 81 219098 28704 46438179
Drug screen false positive 12.67 9.59 18 219161 859 46466024
Carbohydrate antigen 125 increased 12.59 9.59 32 219147 2378 46464505
Alcohol abuse 12.57 9.59 30 219149 2142 46464741
Joint injury 12.56 9.59 47 219132 19162 46447721
Pulmonary arterial hypertension 12.46 9.59 71 219108 25857 46441026
Soft tissue swelling 12.34 9.59 18 219161 880 46466003
Apathy 12.33 9.59 67 219112 7201 46459682
Rabbit syndrome 12.31 9.59 11 219168 312 46466571
Restless legs syndrome 12.27 9.59 121 219058 15722 46451161
Psychotic symptom 12.16 9.59 18 219161 892 46465991
Monocyte count decreased 12.10 9.59 26 219153 1731 46465152
Parachute mitral valve 12.07 9.59 7 219172 98 46466785
Balance disorder 12.00 9.59 392 218787 64129 46402754
Depressive delusion 11.98 9.59 4 219175 12 46466871
Autologous bone marrow transplantation therapy 11.98 9.59 4 219175 12 46466871
Thinking abnormal 11.93 9.59 83 219096 9731 46457152
Joint effusion 11.85 9.59 24 219155 11971 46454912
Colitis ulcerative 11.84 9.59 43 219136 17689 46449194
Device breakage 11.77 9.59 17 219162 9675 46457208
Leukopenia neonatal 11.72 9.59 5 219174 34 46466849
Impaired driving ability 11.71 9.59 45 219134 4179 46462704
Hypoglycaemia 11.68 9.59 182 218997 54167 46412716
Blood magnesium decreased 11.67 9.59 90 219089 10902 46455981
Stevens-Johnson syndrome 11.63 9.59 63 219116 23234 46443649
Pneumonia 11.59 9.59 1569 217610 374751 46092132
Pruritus allergic 11.55 9.59 19 219160 1032 46465851
Eczema eyelids 11.53 9.59 7 219172 107 46466776
Immunodeficiency 11.49 9.59 28 219151 13078 46453805
Injection site rash 11.48 9.59 37 219142 15776 46451107
Schizoaffective disorder bipolar type 11.42 9.59 7 219172 109 46466774
Tendonitis 11.37 9.59 32 219147 14245 46452638
Incision site complication 11.36 9.59 14 219165 581 46466302
Arterial spasm 11.29 9.59 6 219173 70 46466813
Laryngeal stenosis 11.23 9.59 15 219164 675 46466208
Haemoglobin urine 11.20 9.59 7 219172 113 46466770
Face oedema 11.18 9.59 49 219130 19104 46447779
Antidepressant drug level above therapeutic 11.17 9.59 11 219168 354 46466529
Drug abuser 11.15 9.59 37 219142 3196 46463687
Periorbital haemorrhage 11.14 9.59 6 219173 72 46466811
Tachyphrenia 11.12 9.59 21 219158 1273 46465610
Drug clearance decreased 11.12 9.59 19 219160 1065 46465818
Toxicologic test abnormal 11.08 9.59 15 219164 684 46466199
Antidepressant drug level decreased 11.03 9.59 3 219176 3 46466880
Benzodiazepine drug level 11.03 9.59 3 219176 3 46466880
Drug resistance 11.03 9.59 43 219136 17325 46449558
Hypercapnia 11.00 9.59 47 219132 4579 46462304
Pain in jaw 11.00 9.59 121 219058 38251 46428632
Pleural adhesion 10.99 9.59 7 219172 117 46466766
Bone density decreased 10.98 9.59 18 219161 9734 46457149
Inflammatory marker increased 10.98 9.59 6 219173 5469 46461414
Respiratory disorder 10.95 9.59 79 219100 27221 46439662
Dysmetropsia 10.93 9.59 6 219173 75 46466808
Rash pruritic 10.93 9.59 144 219035 44071 46422812
Cellulitis 10.88 9.59 249 218930 70039 46396844
Blood immunoglobulin M decreased 10.88 9.59 15 219164 696 46466187
Hypotonia 10.84 9.59 71 219108 8158 46458725
Cyclic vomiting syndrome 10.82 9.59 5 219174 42 46466841
Live birth 10.78 9.59 20 219159 10310 46456573
Kluver-Bucy syndrome 10.73 9.59 4 219175 18 46466865
Water intoxication 10.72 9.59 12 219167 449 46466434
Bulimia nervosa 10.69 9.59 13 219166 532 46466351
Cerebral infarction 10.69 9.59 65 219114 23301 46443582
Acute myocardial infarction 10.68 9.59 97 219082 31827 46435056
Fluid retention 10.61 9.59 172 219007 50874 46416009
Platelet morphology abnormal 10.58 9.59 3 219176 4 46466879
Tachyphylaxis 10.57 9.59 9 219170 239 46466644
Affective ambivalence 10.56 9.59 4 219175 19 46466864
Stillbirth 10.50 9.59 9 219170 6482 46460401
Influenza 10.48 9.59 329 218850 88941 46377942
False positive investigation result 10.48 9.59 13 219166 543 46466340
Discomfort 10.46 9.59 155 219024 46515 46420368
Neuropsychiatric symptoms 10.45 9.59 12 219167 462 46466421
Benzodiazepine drug level increased 10.44 9.59 8 219171 182 46466701
Hypopnoea 10.43 9.59 30 219149 2398 46464485
Dysaesthesia pharynx 10.40 9.59 7 219172 129 46466754
Tongue movement disturbance 10.37 9.59 8 219171 184 46466699
Respiratory fatigue 10.34 9.59 6 219173 84 46466799
Floppy infant 10.34 9.59 6 219173 84 46466799
Tenosynovitis 10.34 9.59 12 219167 7503 46459380
Coeliac disease 10.33 9.59 11 219168 7150 46459733
Impaired work ability 10.30 9.59 28 219151 12608 46454275
Pathogen resistance 10.30 9.59 8 219171 6052 46460831
Blunted affect 10.29 9.59 8 219171 186 46466697
Injection site extravasation 10.27 9.59 10 219169 6775 46460108
Depressive symptom 10.27 9.59 33 219146 2803 46464080
Drug level increased 10.26 9.59 132 219047 18309 46448574
Systolic hypertension 10.26 9.59 11 219168 392 46466491
Nausea 10.25 9.59 3486 215693 683968 45782915
Respiratory rate decreased 10.20 9.59 35 219144 3075 46463808
Vomiting 10.17 9.59 2336 216843 450458 46016425
Wrong strength 10.16 9.59 5 219174 49 46466834
Neurological decompensation 10.14 9.59 25 219154 1823 46465060
Joint stiffness 10.13 9.59 80 219099 27028 46439855
Ankylosing spondylitis 10.12 9.59 10 219169 6727 46460156
Incoherent 10.09 9.59 45 219134 4467 46462416
Osteonecrosis 10.08 9.59 75 219104 25669 46441214
Suspected suicide 10.06 9.59 46 219133 4615 46462268
Drug diversion 10.06 9.59 16 219163 845 46466038
Klebsiella bacteraemia 10.00 9.59 19 219160 1157 46465726
Intestinal strangulation 9.98 9.59 6 219173 90 46466793
Feeling of body temperature change 9.96 9.59 43 219136 4209 46462674
Induced abortion failed 9.91 9.59 9 219170 261 46466622
Mean cell haemoglobin increased 9.91 9.59 26 219153 1970 46464913
Areflexia 9.90 9.59 34 219145 2989 46463894
Coronary artery disease 9.85 9.59 106 219073 33646 46433237
Hyponatraemic syndrome 9.84 9.59 13 219166 579 46466304
Gallbladder cholesterolosis 9.80 9.59 15 219164 766 46466117
Natural killer cell count 9.79 9.59 4 219175 24 46466859
Amegakaryocytic thrombocytopenia 9.79 9.59 4 219175 24 46466859
Patent ductus arteriosus 9.78 9.59 40 219139 3822 46463061
Asthenia 9.77 9.59 1632 217547 309443 46157440
Bronchiectasis 9.76 9.59 18 219161 9298 46457585
Laryngitis 9.76 9.59 18 219161 9298 46457585
Irregular breathing 9.74 9.59 9 219170 267 46466616
Myocardial infarction 9.70 9.59 367 218812 97161 46369722
Stereotypy 9.69 9.59 11 219168 418 46466465
Bradycardia 9.69 9.59 392 218787 65906 46400977
Antidepressant drug level increased 9.66 9.59 9 219170 270 46466613
Forced expiratory volume decreased 9.65 9.59 6 219173 5098 46461785
Oropharyngeal swelling 9.65 9.59 16 219163 875 46466008
Inappropriate antidiuretic hormone secretion 9.64 9.59 105 219074 13997 46452886
Erysipelas 9.63 9.59 11 219168 6927 46459956

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sopor 709.61 10.12 489 126013 10502 29815474
Agitation 395.40 10.12 770 125732 53303 29772673
Drug abuse 356.89 10.12 951 125551 81121 29744855
Neuroleptic malignant syndrome 340.21 10.12 381 126121 15914 29810062
Catatonia 335.95 10.12 217 126285 4163 29821813
Intentional self-injury 274.97 10.12 312 126190 13220 29812756
Anxiety 238.86 10.12 878 125624 88993 29736983
Sedation 236.59 10.12 318 126184 16055 29809921
Bradyphrenia 231.91 10.12 166 126336 3791 29822185
Suicide attempt 219.15 10.12 481 126021 36216 29789760
Completed suicide 212.00 10.12 907 125595 98585 29727391
Aggression 188.65 10.12 455 126047 36452 29789524
Delirium 184.68 10.12 479 126023 40152 29785824
Psychotic disorder 157.81 10.12 307 126195 21208 29804768
Somnolence 152.76 10.12 809 125693 95954 29730022
Extrapyramidal disorder 118.30 10.12 183 126319 10510 29815466
Schizophrenia 116.10 10.12 166 126336 8882 29817094
Confusional state 115.66 10.12 968 125534 133866 29692110
Intentional overdose 113.17 10.12 409 126093 41072 29784904
Drug withdrawal syndrome 111.86 10.12 254 126248 19555 29806421
Interstitial lung disease 100.73 10.12 65 126437 60132 29765844
Hallucination, auditory 95.23 10.12 158 126344 9631 29816345
Mental status changes 86.63 10.12 348 126154 36731 29789245
Overdose 86.32 10.12 631 125871 83706 29742270
Suicidal ideation 86.02 10.12 341 126161 35773 29790203
Muscle rigidity 84.65 10.12 154 126348 10107 29815869
Restlessness 82.44 10.12 246 126256 22353 29803623
Rheumatoid arthritis 79.79 10.12 37 126465 41160 29784816
Psoriasis 78.05 10.12 41 126461 42465 29783511
Tachycardia 76.76 10.12 554 125948 73185 29752791
Akathisia 76.75 10.12 109 126393 5795 29820181
Parkinsonism 75.69 10.12 121 126381 7148 29818828
Acute kidney injury 71.07 10.12 777 125725 273065 29552911
Dysarthria 65.58 10.12 279 126223 30211 29795765
Toxicity to various agents 64.63 10.12 1079 125423 176104 29649872
Drug dependence 64.13 10.12 217 126285 21078 29804898
Granulocytopenia 62.59 10.12 102 126400 6124 29819852
Disorientation 59.64 10.12 277 126225 31141 29794835
Renal impairment 58.78 10.12 172 126330 84012 29741964
Seizure 58.62 10.12 655 125847 97820 29728156
Unresponsive to stimuli 57.78 10.12 243 126259 26176 29799800
Abnormal behaviour 54.74 10.12 234 126268 25389 29800587
Depressed level of consciousness 51.85 10.12 307 126195 37915 29788061
Psychomotor hyperactivity 51.56 10.12 110 126392 8114 29817862
Withdrawal syndrome 50.42 10.12 132 126370 11118 29814858
Joint swelling 49.46 10.12 76 126426 46870 29779106
Poverty of speech 49.33 10.12 22 126480 190 29825786
Paranoia 46.13 10.12 120 126382 10068 29815908
Dyskinesia 45.56 10.12 198 126304 21636 29804340
Anaemia 45.54 10.12 612 125890 207380 29618596
Hypokinesia 45.39 10.12 97 126405 7163 29818813
Cytomegalovirus infection 44.70 10.12 22 126480 23652 29802324
Cardiac failure 44.48 10.12 191 126311 83227 29742749
Speech disorder 44.25 10.12 213 126289 24299 29801677
Delusion 43.24 10.12 130 126372 11859 29814117
Withdrawal catatonia 42.61 10.12 15 126487 63 29825913
Hallucination 42.36 10.12 353 126149 48706 29777270
Stupor 42.10 10.12 57 126445 2896 29823080
Refusal of treatment by patient 41.88 10.12 76 126426 4977 29820999
Respiratory depression 41.74 10.12 125 126377 11378 29814598
Product dose omission issue 41.73 10.12 222 126280 91409 29734567
Cholestasis 41.63 10.12 27 126475 24923 29801053
Blood creatine phosphokinase increased 40.83 10.12 321 126181 43527 29782449
Psoriatic arthropathy 39.57 10.12 9 126493 15752 29810224
Dystonia 39.44 10.12 110 126392 9617 29816359
Drug ineffective 39.42 10.12 1116 125386 339271 29486705
Myocardial infarction 39.41 10.12 340 126162 125285 29700691
Major depression 39.22 10.12 65 126437 3957 29822019
Psychomotor retardation 38.69 10.12 49 126453 2330 29823646
Depression 38.69 10.12 566 125936 89871 29736105
Treatment failure 38.62 10.12 54 126448 34625 29791351
Hepatic function abnormal 38.60 10.12 74 126428 41871 29784105
Hyperkalaemia 38.42 10.12 146 126356 65864 29760112
Sinus tachycardia 38.20 10.12 148 126354 15356 29810620
Status epilepticus 38.01 10.12 118 126384 10954 29815022
Homicide 37.78 10.12 33 126469 1013 29824963
Cardiac failure congestive 37.60 10.12 206 126296 84201 29741775
Mental impairment 36.72 10.12 104 126398 9173 29816803
Hyperammonaemic encephalopathy 36.57 10.12 42 126460 1802 29824174
Multiple organ dysfunction syndrome 35.93 10.12 142 126360 63345 29762631
Irritability 35.79 10.12 192 126310 22858 29803118
Pruritus 35.28 10.12 324 126178 117880 29708096
Visceral congestion 34.61 10.12 24 126478 520 29825456
Bone marrow failure 34.56 10.12 45 126457 29740 29796236
Psychotic symptom 34.16 10.12 33 126469 1156 29824820
Diet refusal 33.84 10.12 20 126482 325 29825651
Drug screen positive 33.66 10.12 64 126438 4343 29821633
Antipsychotic drug level increased 33.37 10.12 53 126449 3113 29822863
Salivary hypersecretion 33.11 10.12 88 126414 7478 29818498
Tremor 32.76 10.12 473 126029 74890 29751086
Treatment noncompliance 32.43 10.12 200 126302 25053 29800923
Drug reaction with eosinophilia and systemic symptoms 32.08 10.12 44 126458 28444 29797532
Serotonin syndrome 31.95 10.12 155 126347 17736 29808240
Arthralgia 31.72 10.12 394 126108 135397 29690579
Negativism 31.58 10.12 20 126482 370 29825606
Coronary artery disease 31.55 10.12 106 126396 49606 29776370
Acute myocardial infarction 31.51 10.12 116 126386 52823 29773153
Peripheral swelling 31.23 10.12 142 126360 60932 29765044
Bradykinesia 31.23 10.12 52 126450 3178 29822798
Oropharyngeal spasm 31.14 10.12 15 126487 157 29825819
Electrocardiogram QT prolonged 31.01 10.12 258 126244 35577 29790399
Coma 30.73 10.12 283 126219 40166 29785810
Pleurothotonus 30.54 10.12 29 126473 994 29824982
Ataxia 30.37 10.12 112 126390 11350 29814626
Oral discharge 30.24 10.12 14 126488 133 29825843
Mutism 29.99 10.12 25 126477 719 29825257
Impulsive behaviour 29.65 10.12 39 126463 1926 29824050
Anaphylactic shock 29.61 10.12 11 126491 13982 29811994
Peritonitis bacterial 29.58 10.12 6 126496 11372 29814604
Drug withdrawal convulsions 29.29 10.12 30 126472 1129 29824847
Lethargy 29.27 10.12 275 126227 39244 29786732
Self-injurious ideation 29.17 10.12 35 126467 1574 29824402
Angioedema 28.81 10.12 64 126438 34320 29791656
Rash 28.44 10.12 606 125896 191283 29634693
Synovitis 27.98 10.12 4 126498 9779 29816197
Hypoglycaemia 26.99 10.12 117 126385 50864 29775112
Dysphoria 26.95 10.12 39 126463 2109 29823867
Incoherent 26.88 10.12 56 126446 4062 29821914
Gastrointestinal haemorrhage 26.52 10.12 225 126277 83221 29742755
Dyspnoea 26.46 10.12 1145 125357 332150 29493826
Hypersensitivity 26.22 10.12 128 126374 53900 29772076
Insomnia 25.83 10.12 545 125957 92791 29733185
Panic attack 25.72 10.12 88 126414 8593 29817383
Social avoidant behaviour 24.93 10.12 44 126458 2819 29823157
Haematuria 24.91 10.12 101 126401 44733 29781243
Contraindicated product administered 24.47 10.12 22 126480 17209 29808767
Mental disorder 24.36 10.12 117 126385 13332 29812644
Panic reaction 24.25 10.12 30 126472 1393 29824583
Persecutory delusion 24.19 10.12 37 126465 2103 29823873
Sedation complication 23.68 10.12 23 126479 811 29825165
Parkinsonian gait 23.64 10.12 18 126484 453 29825523
Melaena 23.55 10.12 65 126437 32372 29793604
Cerebrovascular accident 23.53 10.12 232 126270 83245 29742731
Hyperosmolar state 23.05 10.12 17 126485 407 29825569
Mania 23.05 10.12 88 126414 9066 29816910
Jaundice 22.92 10.12 66 126436 32420 29793556
Affect lability 22.92 10.12 47 126455 3371 29822605
Respiratory arrest 22.88 10.12 206 126296 29052 29796924
Confabulation 22.44 10.12 11 126491 120 29825856
Failure to thrive 22.44 10.12 80 126422 7974 29818002
Neologism 22.22 10.12 6 126496 7 29825969
Hallucination, visual 22.21 10.12 130 126372 15983 29809993
Bipolar disorder 21.96 10.12 49 126453 3727 29822249
Blood creatine phosphokinase 21.92 10.12 9 126493 62 29825914
Urticaria 21.79 10.12 138 126364 54468 29771508
Drug resistance 21.77 10.12 32 126470 20101 29805875
Transplant rejection 21.67 10.12 6 126496 9200 29816776
Priapism 21.61 10.12 56 126446 4687 29821289
Amnesia 21.52 10.12 176 126326 24145 29801831
Hepatocellular carcinoma 21.29 10.12 7 126495 9603 29816373
Anaphylactic reaction 21.13 10.12 55 126447 27927 29798049
Anger 21.06 10.12 98 126404 11022 29814954
Alcohol withdrawal syndrome 21.03 10.12 30 126472 1601 29824375
Pain in extremity 21.03 10.12 333 126169 109888 29716088
Flight of ideas 20.97 10.12 15 126487 342 29825634
Hepatocellular injury 20.85 10.12 48 126454 25423 29800553
Drug eruption 20.83 10.12 26 126476 17500 29808476
Schizoaffective disorder 20.78 10.12 24 126478 1036 29824940
Paradoxical drug reaction 20.76 10.12 39 126463 2623 29823353
COVID-19 20.75 10.12 27 126475 17851 29808125
Pathogen resistance 20.72 10.12 5 126497 8405 29817571
Miosis 20.62 10.12 76 126426 7700 29818276
Poisoning 20.60 10.12 99 126403 11283 29814693
Cerebral infarction 20.56 10.12 51 126451 26322 29799654
Renal disorder 20.50 10.12 43 126459 23541 29802435
Hangover 20.45 10.12 24 126478 1054 29824922
Drug intolerance 20.45 10.12 110 126392 45181 29780795
Angina pectoris 20.08 10.12 61 126441 29457 29796519
Blood sodium decreased 20.00 10.12 125 126377 15731 29810245
Inappropriate antidiuretic hormone secretion 19.71 10.12 98 126404 11324 29814652
Injection site pain 19.66 10.12 64 126438 30246 29795730
Floppy infant 19.58 10.12 9 126493 84 29825892
Therapeutic product effect incomplete 19.57 10.12 75 126427 33759 29792217
Communication disorder 19.40 10.12 34 126468 2166 29823810
Antipsychotic drug level decreased 19.32 10.12 21 126481 847 29825129
Sexually inappropriate behaviour 19.32 10.12 14 126488 326 29825650
Aspiration 19.26 10.12 92 126410 10459 29815517
Myocardial fibrosis 18.83 10.12 19 126483 702 29825274
Myelosuppression 18.75 10.12 4 126498 7318 29818658
Epstein-Barr virus infection 18.59 10.12 3 126499 6703 29819273
Multiple drug therapy 18.36 10.12 12 126490 235 29825741
Visual acuity reduced 18.32 10.12 24 126478 15822 29810154
Nervousness 18.16 10.12 98 126404 11690 29814286
Lung disorder 18.04 10.12 70 126432 31399 29794577
Dysphagia 17.99 10.12 338 126164 56360 29769616
Diarrhoea 17.98 10.12 1193 125309 332910 29493066
Drug interaction 17.94 10.12 1022 125480 198546 29627430
Illusion 17.83 10.12 19 126483 749 29825227
Rebound effect 17.66 10.12 27 126475 1534 29824442
Oedema peripheral 17.52 10.12 328 126174 105504 29720472
Hypoxia 17.22 10.12 291 126211 47563 29778413
Haemophagocytic lymphohistiocytosis 17.16 10.12 10 126492 9781 29816195
Staring 17.14 10.12 26 126476 1467 29824509
Arthritis 16.91 10.12 50 126452 24351 29801625
Myocarditis 16.65 10.12 85 126417 9926 29816050
Off label use 16.64 10.12 872 125630 248418 29577558
Affective disorder 16.60 10.12 39 126463 3069 29822907
Drop attacks 16.59 10.12 16 126486 559 29825417
Erythema 16.49 10.12 229 126273 77222 29748754
Sleep disorder 16.48 10.12 167 126335 24312 29801664
Immune reconstitution inflammatory syndrome 16.38 10.12 9 126493 9092 29816884
Renal failure 16.36 10.12 417 126085 128549 29697427
Loss of consciousness 16.33 10.12 445 126057 78930 29747046
Urinary incontinence 16.31 10.12 125 126377 16815 29809161
Loose associations 16.26 10.12 7 126495 55 29825921
Faecaloma 16.10 10.12 48 126454 4357 29821619
Pressure of speech 16.08 10.12 14 126488 428 29825548
Tubulointerstitial nephritis 16.07 10.12 32 126470 17859 29808117
Purple glove syndrome 15.95 10.12 7 126495 58 29825918
Cerebral haemorrhage 15.90 10.12 78 126424 32809 29793167
Oculogyric crisis 15.86 10.12 24 126478 1351 29824625
Liver disorder 15.86 10.12 68 126434 29654 29796322
Atrial fibrillation 15.83 10.12 342 126160 107782 29718194
Testicular atrophy 15.77 10.12 15 126487 515 29825461
Pyrexia 15.58 10.12 1053 125449 293436 29532540
Colitis ulcerative 15.55 10.12 23 126479 14411 29811565
Disturbance in attention 15.40 10.12 152 126350 21977 29803999
Posturing 15.40 10.12 15 126487 531 29825445
Self esteem decreased 15.40 10.12 15 126487 531 29825445
Feelings of worthlessness 15.33 10.12 10 126492 195 29825781
Movement disorder 15.12 10.12 82 126420 9801 29816175
Cough 14.95 10.12 410 126092 125232 29700744
Poor sucking reflex 14.79 10.12 11 126491 267 29825709
Body temperature increased 14.75 10.12 110 126392 14670 29811306
Eczema 14.70 10.12 21 126481 13348 29812628
Infective pulmonary exacerbation of cystic fibrosis 14.68 10.12 9 126493 8563 29817413
Prostate cancer 14.58 10.12 52 126450 23905 29802071
Blood urea nitrogen/creatinine ratio decreased 14.53 10.12 6 126496 42 29825934
Haematuria traumatic 14.52 10.12 9 126493 160 29825816
Neonatal tachypnoea 14.27 10.12 8 126494 117 29825859
Cognitive disorder 14.26 10.12 158 126344 23532 29802444
Blood chloride abnormal 14.25 10.12 4 126498 6 29825970
Negative thoughts 14.14 10.12 16 126486 675 29825301
Myelodysplastic syndrome 14.11 10.12 37 126465 18741 29807235
Obsessive-compulsive disorder 14.09 10.12 44 126458 4097 29821879
Arthropathy 13.98 10.12 43 126459 20684 29805292
Generalised tonic-clonic seizure 13.95 10.12 135 126367 19416 29806560
Soliloquy 13.94 10.12 12 126490 361 29825615
Vascular stenosis 13.91 10.12 9 126493 173 29825803
Infection 13.85 10.12 239 126263 77835 29748141
Bladder cancer 13.68 10.12 11 126491 9091 29816885
Hepatic failure 13.59 10.12 86 126416 33957 29792019
Polyneuropathy 13.57 10.12 18 126484 11805 29814171
Adjustment disorder 13.54 10.12 17 126485 801 29825175
Selective mutism 13.54 10.12 6 126496 51 29825925
Neutropenic sepsis 13.48 10.12 17 126485 11392 29814584
Fear 13.44 10.12 85 126417 10740 29815236
Hallucination, olfactory 13.43 10.12 9 126493 184 29825792
Periorbital pain 13.41 10.12 3 126499 0 29825976
Hypercapnia 13.35 10.12 41 126461 3783 29822193
Pneumonia aspiration 13.32 10.12 229 126273 37551 29788425
Homicidal ideation 13.26 10.12 31 126471 2432 29823544
Septic shock 13.21 10.12 189 126313 63418 29762558
Derealisation 13.20 10.12 14 126488 549 29825427
Pharyngeal paraesthesia 13.19 10.12 12 126490 389 29825587
Myalgia 13.18 10.12 236 126266 76431 29749545
Blood alkaline phosphatase decreased 13.14 10.12 15 126487 639 29825337
Growth hormone deficiency 13.06 10.12 9 126493 193 29825783
Pulmonary fibrosis 12.96 10.12 30 126472 15860 29810116
Sexual dysfunction 12.96 10.12 55 126447 5946 29820030
Mobility decreased 12.96 10.12 61 126441 25938 29800038
Blood count abnormal 12.95 10.12 89 126413 11563 29814413
Echolalia 12.90 10.12 9 126493 197 29825779
Nasal congestion 12.89 10.12 38 126464 18528 29807448
Shoshin beriberi 12.87 10.12 6 126496 58 29825918
Haematotoxicity 12.81 10.12 5 126497 6165 29819811
Skin ulcer 12.79 10.12 39 126463 18810 29807166
Thrombocytopenia 12.72 10.12 462 126040 136582 29689394
Blood prolactin increased 12.57 10.12 22 126480 1400 29824576
Cardiac disorder 12.47 10.12 108 126394 39785 29786191
Glycosylated haemoglobin increased 12.45 10.12 13 126489 9478 29816498
Acute coronary syndrome 12.43 10.12 24 126478 13549 29812427
Nephropathy toxic 12.42 10.12 16 126486 10623 29815353
Phonophobia 12.39 10.12 7 126495 104 29825872
Perseveration 12.34 10.12 7 126495 105 29825871
Herpes zoster 12.29 10.12 75 126427 29868 29796108
Victim of child abuse 12.22 10.12 10 126492 280 29825696
Waxy flexibility 12.16 10.12 7 126495 108 29825868
Febrile neutropenia 12.15 10.12 559 125943 106134 29719842
Creutzfeldt-Jakob disease 12.11 10.12 5 126497 35 29825941
Delusion of grandeur 12.08 10.12 11 126491 357 29825619
Proteinuria 11.98 10.12 32 126470 16113 29809863
Ureteric obstruction 11.97 10.12 20 126482 1226 29824750
Peritonitis 11.96 10.12 48 126454 21327 29804649
Osteonecrosis 11.96 10.12 32 126470 16103 29809873
Respiratory acidosis 11.93 10.12 42 126460 4160 29821816
Gingival oedema 11.93 10.12 4 126498 14 29825962
Pneumocystis jirovecii pneumonia 11.92 10.12 35 126467 17085 29808891
Transient acantholytic dermatosis 11.89 10.12 6 126496 70 29825906
Tangentiality 11.89 10.12 7 126495 113 29825863
Tuberculosis 11.84 10.12 10 126492 8067 29817909
Pulmonary tuberculosis 11.75 10.12 3 126499 4854 29821122
Disorganised speech 11.73 10.12 13 126489 536 29825440
Hypomania 11.71 10.12 28 126474 2228 29823748
Blood creatinine increased 11.70 10.12 295 126207 91080 29734896
Neurodegenerative disorder 11.60 10.12 9 126493 233 29825743
Injection site swelling 11.55 10.12 12 126490 8768 29817208
Panic disorder 11.47 10.12 19 126483 1156 29824820
Antipsychotic drug level above therapeutic 11.40 10.12 18 126484 1052 29824924
Feeling jittery 11.39 10.12 39 126463 3809 29822167
Congenital pulmonary valve atresia 11.39 10.12 6 126496 77 29825899
Injection site erythema 11.38 10.12 26 126476 13808 29812168
Anorectal operation 11.35 10.12 3 126499 3 29825973
Blood count 11.35 10.12 3 126499 3 29825973
Pulse pressure increased 11.35 10.12 3 126499 3 29825973
Thought withdrawal 11.35 10.12 3 126499 3 29825973
Pneumonia 11.30 10.12 1238 125264 333068 29492908
Asthma 11.28 10.12 98 126404 36076 29789900
Pancreatitis acute 11.27 10.12 63 126439 25632 29800344
Immunosuppressant drug level increased 11.19 10.12 3 126499 4699 29821277
Dementia with Lewy bodies 11.15 10.12 13 126489 567 29825409
Blood uric acid abnormal 11.13 10.12 6 126496 81 29825895
Drug monitoring procedure incorrectly performed 11.12 10.12 8 126494 184 29825792
Device issue 11.07 10.12 10 126492 7806 29818170
Balance disorder 11.04 10.12 216 126286 36277 29789699
Apnoea 11.02 10.12 54 126448 6204 29819772
Malaise 10.93 10.12 585 125917 166377 29659599
Paediatric autoimmune neuropsychiatric disorders associated with streptococcal infection 10.89 10.12 3 126499 4 29825972
Muscle mass 10.88 10.12 9 126493 256 29825720
C-reactive protein abnormal 10.86 10.12 5 126497 5588 29820388
Injection site pruritus 10.86 10.12 5 126497 5587 29820389
Therapeutic product effect decreased 10.83 10.12 75 126427 29001 29796975
Mydriasis 10.81 10.12 53 126449 6090 29819886
Hyperhidrosis 10.80 10.12 365 126137 66725 29759251
Electroencephalogram abnormal 10.78 10.12 28 126474 2346 29823630
Grandiosity 10.77 10.12 10 126492 333 29825643
Acute respiratory distress syndrome 10.60 10.12 57 126445 23415 29802561
Gastric ulcer 10.46 10.12 31 126471 15090 29810886
Head injury 10.46 10.12 114 126388 16906 29809070
Lip swelling 10.44 10.12 24 126478 12720 29813256
Blood potassium decreased 10.43 10.12 112 126390 16550 29809426
Basal cell carcinoma 10.37 10.12 34 126468 16034 29809942
Poor quality sleep 10.36 10.12 59 126443 7182 29818794
Hypertensive crisis 10.35 10.12 12 126490 8345 29817631
Staphylococcal infection 10.28 10.12 80 126422 30144 29795832
Product use in unapproved indication 10.23 10.12 235 126267 73458 29752518
Tachyphrenia 10.21 10.12 17 126485 1039 29824937
Acute stress disorder 10.20 10.12 7 126495 149 29825827
Thinking abnormal 10.20 10.12 47 126455 5264 29820712
Cerebrovascular stenosis 10.18 10.12 6 126496 97 29825879
Medical device site irritation 10.14 10.12 3 126499 6 29825970
Assisted suicide 10.14 10.12 3 126499 6 29825970
Echopraxia 10.14 10.12 3 126499 6 29825970
Drug screen false positive 10.13 10.12 14 126488 725 29825251

Pharmacologic Action:

SourceCodeDescription
ATC N05BA06 NERVOUS SYSTEM
PSYCHOLEPTICS
ANXIOLYTICS
Benzodiazepine derivatives
ATC N05BA56 NERVOUS SYSTEM
PSYCHOLEPTICS
ANXIOLYTICS
Benzodiazepine derivatives
FDA CS M0002356 Benzodiazepines
FDA EPC N0000175694 Benzodiazepine
MeSH PA D018757 GABA Modulators
MeSH PA D014151 Anti-Anxiety Agents
MeSH PA D000927 Anticonvulsants
MeSH PA D000932 Antiemetics
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018682 GABA Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D006993 Hypnotics and Sedatives
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents
CHEBI has role CHEBI:35717 sedatives

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Myoclonic seizure indication 37356005
Atonic seizure indication 42365007
Anxiety indication 48694002
Absence seizure indication 79631006
Lennox-Gastaut syndrome indication 230418006
Status epilepticus indication 230456007 DOID:1824
Panic disorder indication 371631005 DOID:594
Sedation as Adjunct to Anesthesia indication
Induce Anterograde Amnesia indication
Delirium off-label use 2776000
Alcohol withdrawal delirium off-label use 8635005
General anesthesia off-label use 50697003
Seizure disorder off-label use 128613002
Alcohol withdrawal syndrome off-label use 191480000
Insomnia off-label use 193462001
Spasticity off-label use 221360009
Chemotherapy-induced nausea and vomiting off-label use 236084000
Akathisia off-label use 285145004
Local anesthesia off-label use 386761002
Cocaine-Associated Acute Ischemic Heart Disease off-label use
Manic Bipolar Disorder Adjunct Treatment off-label use
Sedation in Intubated Patients off-label use
Suicidal thoughts contraindication 6471006
Hepatic encephalopathy contraindication 13920009 DOID:13413
Alcohol intoxication contraindication 25702006
Depressive disorder contraindication 35489007
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Substance abuse contraindication 66214007
Sleep apnea contraindication 73430006 DOID:0050847
Decreased respiratory function contraindication 80954004
Open-angle glaucoma contraindication 84494001 DOID:1067
Kidney disease contraindication 90708001 DOID:557
Hypoalbuminemia contraindication 119247004
Liver function tests abnormal contraindication 166603001
Disease of liver contraindication 235856003 DOID:409
Syncope contraindication 271594007
Pregnancy, function contraindication 289908002
Severe chronic obstructive pulmonary disease contraindication 313299006
At risk for aspiration contraindication 371736008
Angle-closure glaucoma contraindication 392291006 DOID:13550
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Central nervous system depression contraindication 418072004
Porphyria contraindication 418470004

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.09 acidic
pKa2 11.41 acidic
pKa3 0.63 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor alpha-1/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR IC50 8.46 WOMBAT-PK CHEMBL
Fatty acid-binding protein, liver Unclassified Ki 4.89 CHEMBL

External reference:

IDSource
4017848 VUID
N0000146205 NUI
D00365 KEGG_DRUG
4017848 VANDF
C0024002 UMLSCUI
CHEBI:6539 CHEBI
CHEMBL580 ChEMBL_ID
CHEMBL399057 ChEMBL_ID
CHEMBL249262 ChEMBL_ID
D008140 MESH_DESCRIPTOR_UI
3958 PUBCHEM_CID
DB00186 DRUGBANK_ID
5884 IUPHAR_LIGAND_ID
2809 INN_ID
O26FZP769L UNII
202479 RXNORM
2104 MMSL
3795 MMSL
4995 MMSL
d00149 MMSL
001460 NDDF
19225000 SNOMEDCT_US
387106007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0054-3532 SOLUTION, CONCENTRATE 2 mg ORAL ANDA 19 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0121-0770 LIQUID 2 mg ORAL ANDA 21 sections
Ativan HUMAN PRESCRIPTION DRUG LABEL 1 0187-0063 TABLET 0.50 mg ORAL NDA 20 sections
Ativan HUMAN PRESCRIPTION DRUG LABEL 1 0187-0064 TABLET 1 mg ORAL NDA 20 sections
Ativan HUMAN PRESCRIPTION DRUG LABEL 1 0187-0065 TABLET 2 mg ORAL NDA 20 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0409-1539 INJECTION, SOLUTION 4 mg INTRAMUSCULAR ANDA 33 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0409-1985 INJECTION, SOLUTION 2 mg INTRAMUSCULAR ANDA 33 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0409-6778 INJECTION, SOLUTION 2 mg INTRAMUSCULAR ANDA 33 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0409-6778 INJECTION, SOLUTION 2 mg INTRAMUSCULAR ANDA 33 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0409-6779 INJECTION, SOLUTION 4 mg INTRAMUSCULAR ANDA 33 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0409-6780 INJECTION, SOLUTION 2 mg INTRAMUSCULAR ANDA 33 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0409-6781 INJECTION, SOLUTION 4 mg INTRAMUSCULAR ANDA 33 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0591-0240 TABLET 0.50 mg ORAL ANDA 20 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0591-0241 TABLET 1 mg ORAL ANDA 20 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0591-0242 TABLET 2 mg ORAL ANDA 20 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-7805 TABLET 0.50 mg ORAL ANDA 18 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8003 TABLET 0.50 mg ORAL ANDA 18 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8004 TABLET 1 mg ORAL ANDA 18 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8050 TABLET 2 mg ORAL ANDA 18 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8075 TABLET 0.50 mg ORAL ANDA 13 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8076 TABLET 1 mg ORAL ANDA 13 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8077 TABLET 2 mg ORAL ANDA 13 sections
Ativan HUMAN PRESCRIPTION DRUG LABEL 1 0641-6000 INJECTION 2 mg INTRAMUSCULAR NDA 27 sections
Ativan HUMAN PRESCRIPTION DRUG LABEL 1 0641-6001 INJECTION 2 mg INTRAMUSCULAR NDA 27 sections
Ativan HUMAN PRESCRIPTION DRUG LABEL 1 0641-6002 INJECTION 4 mg INTRAMUSCULAR NDA 27 sections
Ativan HUMAN PRESCRIPTION DRUG LABEL 1 0641-6003 INJECTION 4 mg INTRAMUSCULAR NDA 27 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0641-6044 INJECTION 2 mg INTRAMUSCULAR NDA 25 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0641-6045 INJECTION 4 mg INTRAMUSCULAR NDA 25 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0641-6046 INJECTION 2 mg INTRAMUSCULAR NDA 25 sections
Lorazepam HUMAN PRESCRIPTION DRUG LABEL 1 0641-6047 INJECTION 4 mg INTRAMUSCULAR NDA 25 sections