loratadine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
histamine-H1 receptor antagonists, tricyclic compounds 1605 79794-75-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • loratadine
  • claritin
  • loracert
  • loradex
  • loratidine
  • loratyne
A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.
  • Molecular weight: 382.89
  • Formula: C22H23ClN2O2
  • CLOGP: 5.05
  • LIPINSKI: 1
  • HAC: 4
  • HDO: 0
  • TPSA: 42.43
  • ALOGS: -4.46
  • ROTB: 2

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 5 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.44 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 40 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
April 12, 1993 FDA BAYER HEALTHCARE LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Extra dose administered 363.22 9.83 169 75093 4538 46606262
Accidental exposure to product by child 187.69 9.83 70 75192 1053 46609747
Gastrooesophageal reflux disease 130.54 9.83 336 74926 74008 46536792
Failure of child resistant product closure 117.36 9.83 23 75239 9 46610791
Drug ineffective 103.28 9.83 656 74606 677182 45933618
Rheumatoid arthritis 102.19 9.83 143 75119 240072 46370728
Pneumonia aspiration 98.24 9.83 180 75082 31425 46579375
Urticaria 96.38 9.83 411 74851 117481 46493319
Contraindicated product administered 86.15 9.83 13 75249 79934 46530866
Toxicity to various agents 74.21 9.83 143 75119 211623 46399177
Acute kidney injury 69.71 9.83 175 75087 235680 46375120
Sinusitis 69.37 9.83 401 74861 129367 46481433
Drug intolerance 69.24 9.83 81 75181 146968 46463832
Asthma 65.63 9.83 307 74955 91235 46519565
Drug abuse 62.46 9.83 13 75249 63395 46547405
Treatment failure 58.59 9.83 39 75223 93048 46517752
Synovitis 57.20 9.83 14 75248 61061 46549739
Cholecystitis chronic 53.60 9.83 75 75187 10424 46600376
Pruritus 51.01 9.83 606 74656 241746 46369054
Somnolence 50.69 9.83 428 74834 156093 46454707
Maternal exposure during pregnancy 48.78 9.83 56 75206 102493 46508307
Off label use 48.56 9.83 386 74876 379455 46231345
Dizziness 45.90 9.83 787 74475 339627 46271173
Seasonal allergy 45.34 9.83 79 75183 13255 46597545
Infective pulmonary exacerbation of cystic fibrosis 40.69 9.83 67 75195 10740 46600060
Butterfly rash 40.31 9.83 23 75239 951 46609849
Anxiety 39.58 9.83 458 74804 181499 46429301
Pancytopenia 38.79 9.83 48 75214 85010 46525790
Swelling face 38.04 9.83 178 75084 52881 46557919
Insomnia 37.16 9.83 418 74844 164506 46446294
General physical health deterioration 36.45 9.83 83 75179 115686 46495114
Muscle spasms 35.36 9.83 328 74934 122785 46488015
Systemic lupus erythematosus 35.07 9.83 32 75230 65148 46545652
Coma 34.93 9.83 186 75076 58163 46552637
Glossodynia 34.72 9.83 14 75248 44359 46566441
Joint swelling 34.53 9.83 144 75118 165929 46444871
Angioedema 34.32 9.83 140 75122 39202 46571598
Dyspnoea 34.17 9.83 1079 74183 514469 46096331
Rhinitis allergic 33.27 9.83 48 75214 6860 46603940
Chest discomfort 33.08 9.83 254 75008 90015 46520785
Gallbladder disorder 32.67 9.83 81 75181 17417 46593383
C-reactive protein increased 32.44 9.83 28 75234 58562 46552238
Palpitations 31.61 9.83 262 75000 94997 46515803
Multiple organ dysfunction syndrome 30.77 9.83 23 75239 51687 46559113
Emotional distress 30.63 9.83 114 75148 30593 46580207
Hand deformity 30.34 9.83 9 75253 34565 46576235
Sinus disorder 29.18 9.83 75 75187 16488 46594312
Allergy test positive 28.93 9.83 13 75249 321 46610479
Rhabdomyolysis 28.53 9.83 16 75246 41893 46568907
Completed suicide 28.21 9.83 130 75132 145790 46465010
Multiple allergies 28.15 9.83 46 75216 7325 46603475
Cough 27.67 9.83 523 74739 229726 46381074
Injury 26.79 9.83 141 75121 43886 46566914
Drug interaction 26.53 9.83 205 75057 202889 46407911
Hyponatraemia 26.29 9.83 80 75182 101252 46509548
Tinnitus 26.16 9.83 101 75161 27572 46583228
Headache 26.08 9.83 979 74283 477373 46133427
Lactic acidosis 26.04 9.83 11 75251 33898 46576902
Feeling abnormal 25.93 9.83 312 74950 124748 46486052
Death 25.87 9.83 383 74879 335165 46275635
Hepatocellular injury 25.34 9.83 8 75254 29514 46581286
Nasal congestion 25.22 9.83 148 75114 47965 46562835
Depression 24.21 9.83 397 74865 169707 46441093
Rash 24.03 9.83 748 74514 355764 46255036
Therapeutic product effect decreased 23.80 9.83 62 75200 82539 46528261
Acquired haemophilia 23.37 9.83 16 75246 915 46609885
Hypersensitivity 23.34 9.83 356 74906 149965 46460835
Product dose omission issue 23.14 9.83 391 74871 168129 46442671
Wound 23.03 9.83 21 75241 42781 46568019
Throat irritation 22.99 9.83 100 75162 28801 46581999
Periorbital oedema 22.82 9.83 34 75228 5001 46605799
Expired product administered 22.72 9.83 36 75226 5586 46605214
Thrombocytopenia 22.59 9.83 116 75146 126465 46484335
Sopor 21.87 9.83 3 75259 19825 46590975
Bronchitis 21.79 9.83 264 74998 105715 46505085
Hyperkalaemia 21.69 9.83 30 75232 50679 46560121
Tinea pedis 21.49 9.83 18 75244 1395 46609405
Arthropathy 21.17 9.83 68 75194 84632 46526168
Malignant neoplasm progression 20.87 9.83 46 75216 64880 46545920
Upper respiratory tract infection 20.64 9.83 174 75088 63382 46547418
Hypersomnia 20.41 9.83 63 75199 15376 46595424
Septic shock 20.32 9.83 39 75223 57854 46552946
Lip swelling 20.30 9.83 88 75174 25307 46585493
C-reactive protein abnormal 19.67 9.83 5 75257 21265 46589535
Cardiac failure 19.42 9.83 65 75197 79883 46530917
Leukopenia 19.15 9.83 52 75210 68291 46542509
Biliary dyskinesia 19.15 9.83 23 75239 2750 46608050
Renal impairment 19.08 9.83 59 75203 74313 46536487
Wheezing 18.87 9.83 149 75113 53237 46557563
Sinus headache 18.86 9.83 30 75232 4670 46606130
Oropharyngeal pain 18.54 9.83 192 75070 73976 46536824
Fatigue 18.41 9.83 1176 74086 607521 46003279
Osteonecrosis of jaw 18.37 9.83 17 75245 34385 46576415
Drug resistance 18.30 9.83 3 75259 17365 46593435
Anaphylactic reaction 18.10 9.83 147 75115 52965 46557835
Essential hypertension 17.98 9.83 28 75234 4282 46606518
Premature baby 17.25 9.83 4 75258 18108 46592692
Lupus hepatitis 16.94 9.83 5 75257 34 46610766
Alopecia 16.78 9.83 174 75088 162240 46448560
Photosensitivity reaction 16.72 9.83 52 75210 12740 46598060
Therapeutic product effect incomplete 16.70 9.83 67 75195 78086 46532714
Allergic cystitis 16.30 9.83 3 75259 0 46610800
Hepatic failure 16.15 9.83 18 75244 33398 46577402
Gallbladder injury 15.91 9.83 15 75247 1359 46609441
Nervousness 15.84 9.83 89 75173 28386 46582414
Chest pain 15.52 9.83 383 74879 175941 46434859
Foetal exposure during pregnancy 15.48 9.83 16 75246 30731 46580069
Cholelithiasis 15.38 9.83 111 75151 38570 46572230
Neutropenia 15.38 9.83 152 75110 143052 46467748
Basophil count decreased 15.36 9.83 6 75256 103 46610697
Victim of chemical submission 15.27 9.83 8 75254 279 46610521
Cystitis noninfective 15.25 9.83 12 75250 851 46609949
Neuropathy peripheral 15.17 9.83 218 75044 90675 46520125
Posterior reversible encephalopathy syndrome 15.12 9.83 3 75259 15138 46595662
Circulatory collapse 15.09 9.83 8 75254 21616 46589184
Abdominal distension 14.76 9.83 182 75080 73169 46537631
Dyspepsia 14.70 9.83 172 75090 68300 46542500
Incorrect dose administered 14.42 9.83 124 75138 45426 46565374
Exposure to toxic agent 14.39 9.83 17 75245 1997 46608803
Status asthmaticus 14.39 9.83 12 75250 924 46609876
Agranulocytosis 14.35 9.83 9 75253 22176 46588624
Overdose 14.22 9.83 101 75161 101878 46508922
Migraine 14.20 9.83 174 75088 69852 46540948
Dry mouth 14.11 9.83 143 75119 54783 46556017
Throat tightness 13.89 9.83 68 75194 20571 46590229
Neurological examination abnormal 13.66 9.83 7 75255 233 46610567
Cardio-respiratory arrest 13.65 9.83 50 75212 59819 46550981
Diarrhoea 13.40 9.83 1061 74201 558541 46052259
Sinus congestion 13.35 9.83 49 75213 13060 46597740
Fracture 13.21 9.83 5 75257 16466 46594334
Infection 13.04 9.83 145 75117 133447 46477353
Mobility decreased 12.91 9.83 52 75210 60542 46550258
Renal failure 12.86 9.83 119 75143 113475 46497325
Suicidal ideation 12.71 9.83 143 75119 56239 46554561
Xanthogranuloma 12.70 9.83 3 75259 7 46610793
Hepatotoxicity 12.61 9.83 13 75249 24996 46585804
Metastases to liver 12.59 9.83 8 75254 19577 46591223
Pericarditis 12.57 9.83 12 75250 23915 46586885
Vision blurred 12.45 9.83 189 75073 79519 46531281
Feeling hot 12.40 9.83 104 75158 37824 46572976
Abdominal pain upper 12.30 9.83 314 74948 144991 46465809
Cytomegalovirus infection 12.24 9.83 7 75255 18137 46592663
Cyclic vomiting syndrome 11.94 9.83 4 75258 43 46610757
Burns first degree 11.69 9.83 3 75259 11 46610789
Acute sinusitis 11.66 9.83 22 75240 3925 46606875
Incorrect dosage administered 11.63 9.83 14 75248 1677 46609123
Pneumocystis jirovecii pneumonia 11.62 9.83 5 75257 15243 46595557
Hypotension 11.56 9.83 286 74976 232303 46378497
Cataract subcapsular 11.54 9.83 9 75253 630 46610170
Reflux gastritis 11.48 9.83 10 75252 817 46609983
Ear congestion 11.48 9.83 14 75248 1701 46609099
Sleep apnoea syndrome 11.44 9.83 68 75194 22133 46588667
Hepatic enzyme increased 11.40 9.83 81 75181 81706 46529094
Upper-airway cough syndrome 11.30 9.83 33 75229 7814 46602986
Deep vein thrombosis 11.26 9.83 186 75076 79587 46531213
Red blood cell sedimentation rate abnormal 11.19 9.83 4 75258 13645 46597155
Mitral valve prolapse 11.16 9.83 16 75246 2273 46608527
Interstitial lung disease 11.06 9.83 47 75215 53902 46556898
Hot flush 11.03 9.83 113 75149 43404 46567396
Nasal oedema 11.03 9.83 10 75252 862 46609938
Acute hepatic failure 10.95 9.83 5 75257 14716 46596084
Multiple lentigines syndrome 10.86 9.83 6 75256 233 46610567
Patellofemoral pain syndrome 10.83 9.83 8 75254 516 46610284
Head discomfort 10.80 9.83 39 75223 10312 46600488
Hypoaesthesia 10.69 9.83 259 75003 118610 46492190
Lower respiratory tract infection 10.68 9.83 49 75213 55040 46555760
Depressed level of consciousness 10.66 9.83 40 75222 47529 46563271
Eye swelling 10.64 9.83 62 75200 20041 46590759
Cluster headache 10.60 9.83 8 75254 533 46610267
Oesophageal adenocarcinoma recurrent 10.49 9.83 3 75259 18 46610782
Cholestasis 10.44 9.83 17 75245 26876 46583924
Bone marrow failure 10.40 9.83 20 75242 29649 46581151
Torsade de pointes 10.40 9.83 43 75219 12111 46598689
Contraindicated product prescribed 10.39 9.83 9 75253 730 46610070
Hypocalcaemia 10.34 9.83 17 75245 26768 46584032
Paraesthesia 10.30 9.83 255 75007 117182 46493618
Bezoar 10.18 9.83 12 75250 1407 46609393
Knee arthroplasty 10.12 9.83 14 75248 23651 46587149
Myxoedema coma 10.10 9.83 7 75255 408 46610392
Musculoskeletal stiffness 10.10 9.83 105 75157 97888 46512912
Eye pruritus 10.10 9.83 42 75220 11856 46598944
Broad ligament tear 10.09 9.83 3 75259 21 46610779
Tympanic membrane disorder 10.02 9.83 5 75257 157 46610643
Status epilepticus 10.01 9.83 5 75257 13974 46596826
Congenital cystic lung 9.97 9.83 3 75259 22 46610778
Presbyoesophagus 9.97 9.83 3 75259 22 46610778
Snoring 9.94 9.83 19 75243 3423 46607377
Rhinorrhoea 9.90 9.83 119 75143 47546 46563254

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Accidental exposure to product by child 314.25 10.65 104 36328 1459 29914587
Extra dose administered 269.15 10.65 109 36323 2777 29913269
Failure of child resistant product closure 91.41 10.65 18 36414 16 29916030
Drug abuse 64.67 10.65 11 36421 82061 29833985
Urticaria 53.53 10.65 167 36265 54439 29861607
General physical health deterioration 44.35 10.65 34 36398 99910 29816136
Drug interaction 42.81 10.65 114 36318 199454 29716592
Infective pulmonary exacerbation of cystic fibrosis 42.01 10.65 52 36380 8520 29907526
Completed suicide 40.27 10.65 37 36395 99455 29816591
Sinusitis 39.38 10.65 109 36323 33236 29882810
Asthma 32.14 10.65 107 36325 36067 29879979
Toxicity to various agents 31.69 10.65 110 36322 177073 29738973
Rash 31.40 10.65 364 36068 191525 29724521
Fatigue 29.41 10.65 550 35882 320123 29595923
Throat irritation 28.46 10.65 43 36389 8505 29907541
Pruritus 28.44 10.65 243 36189 117961 29798085
Sinus disorder 27.71 10.65 36 36396 6189 29909857
Cough 26.00 10.65 250 36182 125392 29790654
Acute kidney injury 25.96 10.65 211 36221 273631 29642415
Expired product administered 25.77 10.65 24 36408 2845 29913201
PO2 increased 22.62 10.65 12 36420 573 29915473
Blood pH decreased 22.18 10.65 20 36412 2275 29913771
Gastrointestinal mucosal necrosis 21.64 10.65 8 36424 158 29915888
Chronic spontaneous urticaria 21.36 10.65 7 36425 95 29915951
Rheumatoid arthritis 20.98 10.65 12 36420 41185 29874861
Treatment failure 20.90 10.65 8 36424 34671 29881375
Drug ineffective 20.63 10.65 291 36141 340096 29575950
Seasonal allergy 20.40 10.65 27 36405 4726 29911320
Dizziness 19.82 10.65 340 36092 194569 29721477
Bronchitis 19.70 10.65 97 36335 39028 29877018
Renal impairment 19.63 10.65 46 36386 84138 29831908
Ultrasound skull abnormal 18.61 10.65 6 36426 77 29915969
CADASIL 18.61 10.65 6 36426 77 29915969
Magnetic resonance imaging spinal abnormal 18.33 10.65 6 36426 81 29915965
Oral pruritus 18.05 10.65 8 36424 256 29915790
Visual evoked potentials abnormal 18.00 10.65 6 36426 86 29915960
Hyperkalaemia 17.98 10.65 33 36399 65977 29850069
Eye pruritus 17.93 10.65 23 36409 3904 29912142
Physical examination abnormal 17.40 10.65 6 36426 96 29915950
Infusion related reaction 17.27 10.65 96 36336 40468 29875578
Wheezing 17.24 10.65 79 36353 30859 29885187
Tunnel vision 17.23 10.65 9 36423 416 29915630
Central nervous system inflammation 17.06 10.65 6 36426 102 29915944
Double stranded DNULL antibody positive 16.90 10.65 6 36426 105 29915941
Swelling face 16.47 10.65 60 36372 21144 29894902
Anxiety 16.25 10.65 174 36258 89697 29826349
Ejaculation delayed 16.21 10.65 7 36425 210 29915836
Tension headache 16.03 10.65 13 36419 1280 29914766
Glossodynia 15.85 10.65 20 36412 3341 29912705
Saccadic eye movement 15.67 10.65 6 36426 131 29915915
Off label use 15.47 10.65 212 36220 249078 29666968
Feeling abnormal 15.42 10.65 120 36312 56636 29859410
Chest pain 15.30 10.65 214 36218 117413 29798633
Drug resistance 15.20 10.65 3 36429 20130 29895916
Upper respiratory tract infection 15.19 10.65 70 36362 27406 29888640
Gastrooesophageal reflux disease 14.86 10.65 78 36354 32177 29883869
Interstitial lung disease 14.76 10.65 32 36400 60165 29855881
Metamorphopsia 14.66 10.65 9 36423 568 29915478
Rhabdomyolysis 14.61 10.65 35 36397 63545 29852501
Suicidal ideation 14.41 10.65 84 36348 36030 29880016
Sleep apnoea syndrome 14.20 10.65 49 36383 16808 29899238
Migraine 14.13 10.65 41 36391 12833 29903213
Vision blurred 14.01 10.65 93 36339 41723 29874323
Lacrimation increased 13.81 10.65 28 36404 6988 29909058
Leukopenia 13.64 10.65 30 36402 56129 29859917
Depression 13.62 10.65 169 36263 90268 29825778
Cerebral microangiopathy 13.48 10.65 6 36426 194 29915852
Lactic acidosis 13.35 10.65 11 36421 31202 29884844
Rhinitis allergic 13.29 10.65 17 36415 2877 29913169
Renal failure 13.29 10.65 97 36335 128869 29787177
Conduction disorder 13.22 10.65 14 36418 1937 29914109
Hyponatraemia 13.18 10.65 40 36392 67162 29848884
Intercepted medication error 13.16 10.65 8 36424 496 29915550
Heart rate increased 12.90 10.65 86 36346 38635 29877411
Chest discomfort 12.82 10.65 97 36335 45383 29870663
Thrombocytopenia 12.76 10.65 106 36326 136938 29779108
Body height decreased 12.74 10.65 19 36413 3715 29912331
PCO2 decreased 12.59 10.65 12 36420 1464 29914582
Septic shock 12.37 10.65 38 36394 63569 29852477
Burning sensation 12.27 10.65 46 36386 16428 29899618
Contraindicated product administered 12.13 10.65 3 36429 17228 29898818
Intentional self-injury 11.99 10.65 40 36392 13492 29902554
Spinal osteoarthritis 11.96 10.65 25 36407 6374 29909672
Lipid metabolism disorder 11.93 10.65 6 36426 256 29915790
Stress at work 11.64 10.65 5 36427 148 29915898
Convulsions local 11.62 10.65 3 36429 16 29916030
Lip swelling 11.58 10.65 38 36394 12706 29903340
Rhinorrhoea 11.57 10.65 53 36379 20701 29895345
Blood cholesterol increased 11.51 10.65 46 36386 16924 29899122
Muscle tightness 11.19 10.65 20 36412 4543 29911503
Upper-airway cough syndrome 11.03 10.65 15 36417 2695 29913351
Insomnia 11.02 10.65 167 36265 93169 29822877
Muscle spasms 11.01 10.65 124 36308 64714 29851332
Bone marrow failure 10.98 10.65 12 36420 29773 29886273
Melaena 10.96 10.65 14 36418 32423 29883623
Hepatocellular injury 10.86 10.65 9 36423 25462 29890584
Metabolic acidosis 10.86 10.65 18 36414 37443 29878603
Dyspnoea 10.82 10.65 502 35930 332793 29583253
Chills 10.81 10.65 135 36297 72203 29843843
Hyperprolactinaemia 10.71 10.65 10 36422 1190 29914856

Pharmacologic Action:

SourceCodeDescription
ATC R06AX13 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Other antihistamines for systemic use
MeSH PA D018926 Anti-Allergic Agents
MeSH PA D000982 Antipruritics
MeSH PA D003879 Dermatologic Agents
MeSH PA D018494 Histamine Agents
MeSH PA D006633 Histamine Antagonists
MeSH PA D006634 Histamine H1 Antagonists
MeSH PA D039563 Histamine H1 Antagonists, Non-Sedating
MeSH PA D018377 Neurotransmitter Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Vasomotor rhinitis indication 8229003 DOID:4730
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Sneezing indication 76067001
Common cold indication 82272006 DOID:10459
Chronic idiopathic urticaria indication 302162004
Seasonal allergic rhinitis indication 367498001
Allergic conjunctivitis indication 473460002 DOID:11204
Bone pain after neupogen off-label use 12584003
Urticaria off-label use 126485001
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Hepatic failure contraindication 59927004
Diabetes mellitus contraindication 73211009 DOID:9351
Kidney disease contraindication 90708001 DOID:557
Impaired renal function disorder contraindication 197663003
Disease of liver contraindication 235856003 DOID:409
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Hypertensive urgency contraindication 443482000

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.43 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Histamine H1 receptor GPCR ANTAGONIST Ki 6.97 WOMBAT-PK CHEMBL
5-hydroxytryptamine receptor 2B GPCR Ki 6.81 DRUG MATRIX
Cytochrome P450 2C19 Enzyme IC50 7.80 DRUG MATRIX
Multidrug resistance protein 1 Transporter Ki 4.94 WOMBAT-PK
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 6.77 WOMBAT-PK
Nuclear receptor subfamily 1 group I member 2 Nuclear hormone receptor EC50 5.52 CHEMBL
Bile acid receptor Nuclear hormone receptor IC50 5.51 CHEMBL
Sodium-dependent neutral amino acid transporter B(0)AT2 Transporter IC50 5.40 CHEMBL
Histamine H1 receptor GPCR Ki 6.46 CHEMBL
Histamine H1 receptor GPCR Kd 7.14 CHEMBL

External reference:

IDSource
4020716 VUID
N0000148306 NUI
D00364 KEGG_DRUG
4020716 VANDF
C0701055 UMLSCUI
CHEBI:6538 CHEBI
CHEMBL998 ChEMBL_ID
D017336 MESH_DESCRIPTOR_UI
DB00455 DRUGBANK_ID
3957 PUBCHEM_CID
7216 IUPHAR_LIGAND_ID
5864 INN_ID
7AJO3BO7QN UNII
203576 RXNORM
191 MMSL
45829 MMSL
4994 MMSL
d03050 MMSL
003909 NDDF
015760 NDDF
108652002 SNOMEDCT_US
386884002 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
allergy relief HUMAN OTC DRUG LABEL 1 0067-6066 TABLET 10 mg ORAL NDA 15 sections
allergy relief HUMAN OTC DRUG LABEL 1 0067-6122 TABLET 10 mg ORAL NDA 15 sections
good sense allergy relief HUMAN OTC DRUG LABEL 1 0113-0612 TABLET 10 mg ORAL ANDA 15 sections
Good Sense childrens allergy relief HUMAN OTC DRUG LABEL 1 0113-0671 SOLUTION 5 mg ORAL ANDA 14 sections
good sense childrens allergy relief HUMAN OTC DRUG LABEL 1 0113-1019 TABLET, CHEWABLE 5 mg ORAL ANDA 15 sections
good sense allergy relief HUMAN OTC DRUG LABEL 1 0113-1191 TABLET, ORALLY DISINTEGRATING 10 mg ORAL ANDA 15 sections
good sense allergy relief HUMAN OTC DRUG LABEL 1 0113-1612 TABLET 10 mg ORAL ANDA 15 sections
good sense childrens allergy relief HUMAN OTC DRUG LABEL 1 0113-1719 SOLUTION 5 mg ORAL ANDA 14 sections
Allergy and Congestion Relief HUMAN OTC DRUG LABEL 2 0113-2007 TABLET, FILM COATED, EXTENDED RELEASE 5 mg ORAL ANDA 14 sections
basic care childrens allergy relief HUMAN OTC DRUG LABEL 1 0113-7500 TABLET, CHEWABLE 5 mg ORAL ANDA 15 sections
Basic Care allergy relief HUMAN OTC DRUG LABEL 1 0113-7612 TABLET 10 mg ORAL ANDA 15 sections
Basic Care Childrens Allergy Relief HUMAN OTC DRUG LABEL 1 0113-7671 SOLUTION 5 mg ORAL ANDA 14 sections
good sense allergy relief HUMAN OTC DRUG LABEL 1 0113-9755 TABLET, ORALLY DISINTEGRATING 10 mg ORAL ANDA 15 sections
Childrens Loratadine HUMAN OTC DRUG LABEL 1 0121-0849 SOLUTION 5 mg ORAL ANDA 16 sections
Loratadine HUMAN OTC DRUG LABEL 1 0363-0522 TABLET 10 mg ORAL ANDA 15 sections
Loratadine HUMAN OTC DRUG LABEL 1 0363-0527 TABLET, ORALLY DISINTEGRATING 10 mg ORAL ANDA 15 sections
Wal itin HUMAN OTC DRUG LABEL 1 0363-0699 TABLET 10 mg ORAL ANDA 15 sections
Loratadine and Pseudoephedrine HUMAN OTC DRUG LABEL 2 0363-0725 TABLET, FILM COATED, EXTENDED RELEASE 10 mg ORAL ANDA 16 sections
Loratadine HUMAN OTC DRUG LABEL 1 0363-0752 TABLET, CHEWABLE 5 mg ORAL ANDA 16 sections
Wal-itin HUMAN OTC DRUG LABEL 1 0363-0754 TABLET, CHEWABLE 5 mg ORAL ANDA 16 sections
Indoor Outdoor Allergy Relief HUMAN OTC DRUG LABEL 1 0363-0858 TABLET 10 mg ORAL ANDA 14 sections
12 hour allergy and congestion HUMAN OTC DRUG LABEL 2 0363-1133 TABLET, FILM COATED, EXTENDED RELEASE 5 mg ORAL ANDA 14 sections
WAL-ITIN HUMAN OTC DRUG LABEL 1 0363-1686 CAPSULE, LIQUID FILLED 10 mg ORAL ANDA 9 sections
Wal-itin Allergy Relief HUMAN OTC DRUG LABEL 1 0363-2085 SOLUTION 5 mg ORAL ANDA 15 sections
Childrens Wal-itin HUMAN OTC DRUG LABEL 1 0363-2092 SOLUTION 5 mg ORAL ANDA 16 sections
Childrens Walitin HUMAN OTC DRUG LABEL 1 0363-2108 SOLUTION 5 mg ORAL ANDA 16 sections
Childrens Loratadine Sugar Free HUMAN OTC DRUG LABEL 1 0363-2131 SOLUTION 5 mg ORAL ANDA 16 sections
Wal-itin D24 Hour HUMAN OTC DRUG LABEL 2 0363-2390 TABLET, EXTENDED RELEASE 10 mg ORAL ANDA 16 sections
CHILDRENS LORATADINE ODT Human OTC Drug Label 1 0363-4020 TABLET, ORALLY DISINTEGRATING 10 mg ORAL ANDA 15 sections
Wal-itin HUMAN OTC DRUG LABEL 1 0363-9150 TABLET 10 mg ORAL ANDA 14 sections