Stem definition | Drug id | CAS RN |
---|---|---|
histamine-H1 receptor antagonists, tricyclic compounds | 1605 | 79794-75-5 |
Dose | Unit | Route |
---|---|---|
10 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.01 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 5 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.44 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 40 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
April 12, 1993 | FDA | BAYER HEALTHCARE LLC |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Extra dose administered | 289.99 | 9.83 | 149 | 85034 | 5324 | 56201560 |
Rheumatoid arthritis | 226.11 | 9.83 | 151 | 85032 | 382453 | 55824431 |
Contraindicated product administered | 212.06 | 9.83 | 19 | 85164 | 186267 | 56020617 |
Synovitis | 190.39 | 9.83 | 14 | 85169 | 161291 | 56045593 |
Drug ineffective | 178.75 | 9.83 | 752 | 84431 | 918237 | 55288647 |
Glossodynia | 174.98 | 9.83 | 15 | 85168 | 152443 | 56054441 |
Accidental exposure to product by child | 170.84 | 9.83 | 65 | 85118 | 1108 | 56205776 |
Hand deformity | 166.67 | 9.83 | 9 | 85174 | 134483 | 56072401 |
Systemic lupus erythematosus | 159.96 | 9.83 | 38 | 85145 | 180040 | 56026844 |
Gastrooesophageal reflux disease | 152.79 | 9.83 | 368 | 84815 | 82889 | 56123995 |
Drug intolerance | 150.32 | 9.83 | 109 | 85074 | 264709 | 55942175 |
Pneumonia aspiration | 146.07 | 9.83 | 211 | 84972 | 32200 | 56174684 |
Treatment failure | 145.46 | 9.83 | 39 | 85144 | 170353 | 56036531 |
Wound | 140.89 | 9.83 | 21 | 85162 | 138783 | 56068101 |
Arthropathy | 130.80 | 9.83 | 70 | 85113 | 200205 | 56006679 |
Pericarditis | 124.19 | 9.83 | 11 | 85172 | 108912 | 56097972 |
Failure of child resistant product closure | 118.81 | 9.83 | 23 | 85160 | 9 | 56206875 |
Joint swelling | 116.66 | 9.83 | 161 | 85022 | 289639 | 55917245 |
Urticaria | 109.91 | 9.83 | 472 | 84711 | 144204 | 56062680 |
Therapeutic product effect decreased | 99.71 | 9.83 | 67 | 85116 | 169385 | 56037499 |
Somnolence | 96.19 | 9.83 | 495 | 84688 | 162918 | 56043966 |
Maternal exposure during pregnancy | 93.91 | 9.83 | 89 | 85094 | 189464 | 56017420 |
General physical health deterioration | 78.31 | 9.83 | 85 | 85098 | 169925 | 56036959 |
Off label use | 77.82 | 9.83 | 508 | 84675 | 555672 | 55651212 |
Hepatic enzyme increased | 77.49 | 9.83 | 87 | 85096 | 171297 | 56035587 |
Asthma | 77.37 | 9.83 | 357 | 84826 | 112413 | 56094471 |
Alopecia | 76.38 | 9.83 | 211 | 84972 | 293247 | 55913637 |
Swelling face | 72.67 | 9.83 | 218 | 84965 | 55851 | 56151033 |
Helicobacter infection | 67.96 | 9.83 | 14 | 85169 | 73254 | 56133630 |
Muscle injury | 66.65 | 9.83 | 3 | 85180 | 52497 | 56154387 |
Toxicity to various agents | 66.55 | 9.83 | 151 | 85032 | 224413 | 55982471 |
Dizziness | 65.88 | 9.83 | 863 | 84320 | 375277 | 55831607 |
Pruritus | 62.96 | 9.83 | 744 | 84439 | 315879 | 55891005 |
Coma | 62.82 | 9.83 | 216 | 84967 | 59439 | 56147445 |
Swelling | 61.91 | 9.83 | 173 | 85010 | 239598 | 55967286 |
Anxiety | 60.96 | 9.83 | 500 | 84683 | 192672 | 56014212 |
Drug abuse | 58.56 | 9.83 | 15 | 85168 | 67595 | 56139289 |
Cholecystitis chronic | 58.51 | 9.83 | 73 | 85110 | 9675 | 56197209 |
Feeling abnormal | 57.79 | 9.83 | 373 | 84810 | 133229 | 56073655 |
Folliculitis | 56.50 | 9.83 | 8 | 85175 | 54971 | 56151913 |
Infective pulmonary exacerbation of cystic fibrosis | 55.34 | 9.83 | 65 | 85118 | 8092 | 56198792 |
Angioedema | 54.49 | 9.83 | 162 | 85021 | 41291 | 56165593 |
Lower respiratory tract infection | 54.40 | 9.83 | 56 | 85127 | 114738 | 56092146 |
Muscle spasms | 54.29 | 9.83 | 375 | 84808 | 136996 | 56069888 |
Insomnia | 53.40 | 9.83 | 483 | 84700 | 191377 | 56015507 |
Butterfly rash | 52.20 | 9.83 | 31 | 85152 | 1475 | 56205409 |
Cough | 52.14 | 9.83 | 612 | 84571 | 259349 | 55947535 |
Sleep disorder due to general medical condition, insomnia type | 50.42 | 9.83 | 4 | 85179 | 43334 | 56163550 |
Chest discomfort | 49.70 | 9.83 | 287 | 84896 | 98570 | 56108314 |
Lip swelling | 49.08 | 9.83 | 117 | 85066 | 26155 | 56180729 |
Dermatitis atopic | 47.98 | 9.83 | 61 | 85122 | 8238 | 56198646 |
Headache | 47.46 | 9.83 | 1143 | 84040 | 557901 | 55648983 |
Discomfort | 47.31 | 9.83 | 89 | 85094 | 141672 | 56065212 |
Palpitations | 47.29 | 9.83 | 285 | 84898 | 99387 | 56107497 |
Musculoskeletal stiffness | 46.11 | 9.83 | 105 | 85078 | 155902 | 56050982 |
Product dose omission issue | 45.55 | 9.83 | 492 | 84691 | 204261 | 56002623 |
C-reactive protein increased | 45.07 | 9.83 | 32 | 85151 | 78652 | 56128232 |
Acute kidney injury | 44.54 | 9.83 | 200 | 84983 | 240563 | 55966321 |
Dyspnoea | 43.68 | 9.83 | 1189 | 83994 | 591388 | 55615496 |
Emotional distress | 41.69 | 9.83 | 119 | 85064 | 29644 | 56177240 |
Bronchitis | 39.96 | 9.83 | 299 | 84884 | 112012 | 56094872 |
Mobility decreased | 38.75 | 9.83 | 56 | 85127 | 98935 | 56107949 |
Sinusitis | 38.63 | 9.83 | 463 | 84720 | 197118 | 56009766 |
Seasonal allergy | 38.45 | 9.83 | 82 | 85101 | 17026 | 56189858 |
Impaired healing | 38.23 | 9.83 | 45 | 85138 | 86796 | 56120088 |
Depression | 36.50 | 9.83 | 425 | 84758 | 179692 | 56027192 |
Tinnitus | 36.29 | 9.83 | 114 | 85069 | 29928 | 56176956 |
Periorbital oedema | 35.86 | 9.83 | 42 | 85141 | 5212 | 56201672 |
Gallbladder disorder | 35.46 | 9.83 | 80 | 85103 | 17254 | 56189630 |
C-reactive protein abnormal | 34.20 | 9.83 | 7 | 85176 | 36802 | 56170082 |
Abdominal discomfort | 33.88 | 9.83 | 263 | 84920 | 277011 | 55929873 |
Knee arthroplasty | 32.68 | 9.83 | 13 | 85170 | 44246 | 56162638 |
Blister | 32.39 | 9.83 | 73 | 85110 | 108814 | 56098070 |
Rhinitis allergic | 32.24 | 9.83 | 51 | 85132 | 8423 | 56198461 |
Pancytopenia | 31.11 | 9.83 | 54 | 85129 | 88661 | 56118223 |
Anaphylactic reaction | 30.77 | 9.83 | 173 | 85010 | 58822 | 56148062 |
Nasal congestion | 30.53 | 9.83 | 167 | 85016 | 56203 | 56150681 |
Therapeutic product effect incomplete | 30.01 | 9.83 | 73 | 85110 | 105958 | 56100926 |
Ill-defined disorder | 29.65 | 9.83 | 36 | 85147 | 68507 | 56138377 |
Infection | 29.33 | 9.83 | 180 | 85003 | 200026 | 56006858 |
Diarrhoea | 28.58 | 9.83 | 1209 | 83974 | 637298 | 55569586 |
Sinus disorder | 28.17 | 9.83 | 82 | 85101 | 20652 | 56186232 |
Throat irritation | 27.41 | 9.83 | 110 | 85073 | 32573 | 56174311 |
Allergy test positive | 27.17 | 9.83 | 13 | 85170 | 397 | 56206487 |
Chest pain | 26.93 | 9.83 | 420 | 84763 | 189377 | 56017507 |
Liver injury | 26.74 | 9.83 | 15 | 85168 | 41833 | 56165051 |
Product use issue | 26.35 | 9.83 | 169 | 85014 | 185872 | 56021012 |
Head discomfort | 26.32 | 9.83 | 57 | 85126 | 11957 | 56194927 |
Upper respiratory tract infection | 26.03 | 9.83 | 191 | 84992 | 71097 | 56135787 |
Mast cell activation syndrome | 25.98 | 9.83 | 15 | 85168 | 677 | 56206207 |
Photosensitivity reaction | 25.89 | 9.83 | 61 | 85122 | 13532 | 56193352 |
Multiple organ dysfunction syndrome | 25.84 | 9.83 | 25 | 85158 | 52745 | 56154139 |
Gastrointestinal disorder | 24.36 | 9.83 | 88 | 85095 | 112614 | 56094270 |
Tinea pedis | 23.57 | 9.83 | 18 | 85165 | 1302 | 56205582 |
Multiple allergies | 23.23 | 9.83 | 50 | 85133 | 10446 | 56196438 |
Acquired haemophilia | 22.91 | 9.83 | 16 | 85167 | 1008 | 56205876 |
Rhabdomyolysis | 22.67 | 9.83 | 17 | 85166 | 40641 | 56166243 |
Feeling hot | 22.09 | 9.83 | 123 | 85060 | 41664 | 56165220 |
Infusion related reaction | 21.99 | 9.83 | 206 | 84977 | 208725 | 55998159 |
Biliary dyskinesia | 21.82 | 9.83 | 23 | 85160 | 2540 | 56204344 |
Essential hypertension | 21.79 | 9.83 | 31 | 85152 | 4662 | 56202222 |
Dry mouth | 21.74 | 9.83 | 169 | 85014 | 64036 | 56142848 |
Throat tightness | 21.74 | 9.83 | 79 | 85104 | 22328 | 56184556 |
Hypersomnia | 21.60 | 9.83 | 64 | 85119 | 16277 | 56190607 |
Oropharyngeal pain | 21.30 | 9.83 | 207 | 84976 | 83581 | 56123303 |
Cystitis noninfective | 21.28 | 9.83 | 15 | 85168 | 959 | 56205925 |
Cystoid macular oedema | 21.12 | 9.83 | 18 | 85165 | 1523 | 56205361 |
Deep vein thrombosis | 20.97 | 9.83 | 193 | 84990 | 76784 | 56130100 |
Paraesthesia | 20.92 | 9.83 | 295 | 84888 | 130219 | 56076665 |
Hepatocellular injury | 20.91 | 9.83 | 7 | 85176 | 26507 | 56180377 |
Nervousness | 20.72 | 9.83 | 93 | 85090 | 28922 | 56177962 |
Vision blurred | 20.64 | 9.83 | 204 | 84979 | 82739 | 56124145 |
Malignant neoplasm progression | 20.55 | 9.83 | 51 | 85132 | 73536 | 56133348 |
Hip arthroplasty | 20.46 | 9.83 | 17 | 85166 | 38606 | 56168278 |
Expired product administered | 20.33 | 9.83 | 33 | 85150 | 5569 | 56201315 |
Eye pruritus | 20.09 | 9.83 | 57 | 85126 | 14149 | 56192735 |
Incorrect dose administered | 19.88 | 9.83 | 142 | 85041 | 52405 | 56154479 |
Abdominal distension | 19.84 | 9.83 | 192 | 84991 | 77434 | 56129450 |
Dry skin | 19.41 | 9.83 | 130 | 85053 | 46979 | 56159905 |
Intentional product use issue | 18.93 | 9.83 | 82 | 85101 | 99651 | 56107233 |
Urinary tract infection | 18.88 | 9.83 | 487 | 84696 | 240026 | 55966858 |
Eye swelling | 18.77 | 9.83 | 73 | 85110 | 21303 | 56185581 |
Bone pain | 18.63 | 9.83 | 135 | 85048 | 50050 | 56156834 |
Suicidal ideation | 18.46 | 9.83 | 150 | 85033 | 57592 | 56149292 |
Cholelithiasis | 18.17 | 9.83 | 112 | 85071 | 39352 | 56167532 |
Migraine | 18.09 | 9.83 | 206 | 84977 | 86591 | 56120293 |
Lupus hepatitis | 17.94 | 9.83 | 5 | 85178 | 29 | 56206855 |
Nausea | 17.70 | 9.83 | 1363 | 83820 | 762815 | 55444069 |
Thrombocytopenia | 17.66 | 9.83 | 127 | 85056 | 136097 | 56070787 |
Status asthmaticus | 17.58 | 9.83 | 13 | 85170 | 896 | 56205988 |
Gallbladder injury | 17.44 | 9.83 | 15 | 85168 | 1285 | 56205599 |
Arthralgia | 17.43 | 9.83 | 603 | 84580 | 501066 | 55705818 |
Condition aggravated | 17.24 | 9.83 | 394 | 84789 | 344504 | 55862380 |
Swollen tongue | 17.20 | 9.83 | 91 | 85092 | 30233 | 56176651 |
Premature baby | 17.13 | 9.83 | 4 | 85179 | 19201 | 56187683 |
Neuropathy peripheral | 17.07 | 9.83 | 234 | 84949 | 102659 | 56104225 |
Abnormal dreams | 16.98 | 9.83 | 42 | 85141 | 9607 | 56197277 |
Renal impairment | 16.80 | 9.83 | 64 | 85119 | 80649 | 56126235 |
Upper-airway cough syndrome | 16.52 | 9.83 | 41 | 85142 | 9397 | 56197487 |
Medication error | 16.51 | 9.83 | 24 | 85159 | 42311 | 56164573 |
Cardiac failure | 16.50 | 9.83 | 66 | 85117 | 82027 | 56124857 |
Allergic cystitis | 16.49 | 9.83 | 3 | 85180 | 0 | 56206884 |
Sinus headache | 16.38 | 9.83 | 28 | 85155 | 4930 | 56201954 |
Septic shock | 16.34 | 9.83 | 43 | 85140 | 60792 | 56146092 |
Temperature intolerance | 16.32 | 9.83 | 37 | 85146 | 8003 | 56198881 |
Red blood cell sedimentation rate increased | 16.09 | 9.83 | 19 | 85164 | 36604 | 56170280 |
Hyperkalaemia | 16.03 | 9.83 | 33 | 85150 | 50832 | 56156052 |
Erythema | 16.03 | 9.83 | 328 | 84855 | 155611 | 56051273 |
Pulmonary fibrosis | 15.89 | 9.83 | 13 | 85170 | 29745 | 56177139 |
Psoriatic arthropathy | 15.85 | 9.83 | 58 | 85125 | 73950 | 56132934 |
Sopor | 15.68 | 9.83 | 6 | 85177 | 20916 | 56185968 |
Basophil count decreased | 15.57 | 9.83 | 6 | 85177 | 106 | 56206778 |
Pulmonary embolism | 15.54 | 9.83 | 238 | 84945 | 106886 | 56099998 |
Illness | 15.30 | 9.83 | 97 | 85086 | 34414 | 56172470 |
Drug resistance | 15.22 | 9.83 | 6 | 85177 | 20536 | 56186348 |
Hepatotoxicity | 14.97 | 9.83 | 15 | 85168 | 31138 | 56175746 |
Pre-existing condition improved | 14.97 | 9.83 | 34 | 85149 | 7364 | 56199520 |
Nasal disorder | 14.96 | 9.83 | 19 | 85164 | 2563 | 56204321 |
Back pain | 14.93 | 9.83 | 467 | 84716 | 236703 | 55970181 |
Posterior reversible encephalopathy syndrome | 14.90 | 9.83 | 3 | 85180 | 15957 | 56190927 |
Inflammation | 14.87 | 9.83 | 54 | 85129 | 69017 | 56137867 |
White blood cell count decreased | 14.64 | 9.83 | 270 | 84913 | 125720 | 56081164 |
Reversible cerebral vasoconstriction syndrome | 14.58 | 9.83 | 18 | 85165 | 2359 | 56204525 |
Dysgeusia | 14.58 | 9.83 | 109 | 85074 | 40806 | 56166078 |
Hyponatraemia | 14.34 | 9.83 | 93 | 85090 | 102046 | 56104838 |
Dyspepsia | 14.32 | 9.83 | 191 | 84992 | 83280 | 56123604 |
Emotional disorder | 14.25 | 9.83 | 46 | 85137 | 12249 | 56194635 |
Loss of personal independence in daily activities | 14.19 | 9.83 | 69 | 85114 | 81300 | 56125584 |
Chills | 14.14 | 9.83 | 226 | 84957 | 102378 | 56104506 |
Crying | 14.04 | 9.83 | 67 | 85116 | 21373 | 56185511 |
Neurological examination abnormal | 13.99 | 9.83 | 7 | 85176 | 236 | 56206648 |
Osteonecrosis of jaw | 13.92 | 9.83 | 18 | 85165 | 33340 | 56173544 |
Hot flush | 13.67 | 9.83 | 119 | 85064 | 46607 | 56160277 |
Completed suicide | 13.62 | 9.83 | 133 | 85050 | 133700 | 56073184 |
Depressed level of consciousness | 13.60 | 9.83 | 42 | 85141 | 56391 | 56150493 |
Chronic spontaneous urticaria | 13.49 | 9.83 | 12 | 85171 | 1075 | 56205809 |
Drug interaction | 13.37 | 9.83 | 230 | 84953 | 209525 | 55997359 |
Injury | 13.36 | 9.83 | 144 | 85039 | 59707 | 56147177 |
Bronchospasm | 13.35 | 9.83 | 53 | 85130 | 15616 | 56191268 |
Reflux gastritis | 13.28 | 9.83 | 12 | 85171 | 1098 | 56205786 |
Agranulocytosis | 13.25 | 9.83 | 9 | 85174 | 22650 | 56184234 |
Victim of chemical submission | 13.04 | 9.83 | 8 | 85175 | 404 | 56206480 |
Impaired quality of life | 12.97 | 9.83 | 35 | 85148 | 8439 | 56198445 |
Red blood cell sedimentation rate abnormal | 12.96 | 9.83 | 6 | 85177 | 18667 | 56188217 |
Anger | 12.93 | 9.83 | 43 | 85140 | 11629 | 56195255 |
Xanthogranuloma | 12.88 | 9.83 | 3 | 85180 | 7 | 56206877 |
Cataract subcapsular | 12.87 | 9.83 | 9 | 85174 | 568 | 56206316 |
Snoring | 12.87 | 9.83 | 21 | 85162 | 3560 | 56203324 |
Initial insomnia | 12.83 | 9.83 | 27 | 85156 | 5552 | 56201332 |
Rash | 12.83 | 9.83 | 888 | 84295 | 492159 | 55714725 |
Oesophageal adenocarcinoma recurrent | 12.82 | 9.83 | 4 | 85179 | 36 | 56206848 |
Palmar erythema | 12.80 | 9.83 | 14 | 85169 | 1613 | 56205271 |
Burning sensation | 12.71 | 9.83 | 121 | 85062 | 48575 | 56158309 |
Mitral valve prolapse | 12.41 | 9.83 | 16 | 85167 | 2190 | 56204694 |
Autoimmune hepatitis | 12.41 | 9.83 | 33 | 85150 | 7888 | 56198996 |
Panic disorder | 12.38 | 9.83 | 17 | 85166 | 2474 | 56204410 |
Cytomegalovirus infection | 12.21 | 9.83 | 7 | 85176 | 19289 | 56187595 |
Cluster headache | 12.20 | 9.83 | 9 | 85174 | 618 | 56206266 |
Fracture | 12.19 | 9.83 | 6 | 85177 | 18012 | 56188872 |
Wheezing | 12.18 | 9.83 | 170 | 85013 | 74856 | 56132028 |
Overdose | 12.15 | 9.83 | 102 | 85081 | 105728 | 56101156 |
Somnambulism | 12.13 | 9.83 | 25 | 85158 | 5067 | 56201817 |
Infusion site erythema | 12.11 | 9.83 | 37 | 85146 | 9569 | 56197315 |
Hepatic failure | 12.09 | 9.83 | 20 | 85163 | 33466 | 56173418 |
Heart rate increased | 12.07 | 9.83 | 185 | 84998 | 83088 | 56123796 |
Acute hepatic failure | 12.02 | 9.83 | 5 | 85178 | 16573 | 56190311 |
Sleep apnoea syndrome | 12.02 | 9.83 | 74 | 85109 | 25987 | 56180897 |
Lactic acidosis | 11.95 | 9.83 | 22 | 85161 | 35324 | 56171560 |
Premature delivery | 11.93 | 9.83 | 14 | 85169 | 27046 | 56179838 |
Sinus congestion | 11.68 | 9.83 | 51 | 85132 | 15673 | 56191211 |
Skin burning sensation | 11.65 | 9.83 | 40 | 85143 | 10991 | 56195893 |
Flushing | 11.45 | 9.83 | 159 | 85024 | 69941 | 56136943 |
Fatigue | 11.44 | 9.83 | 1361 | 83822 | 787191 | 55419693 |
Laryngeal oedema | 11.41 | 9.83 | 25 | 85158 | 5285 | 56201599 |
Acute sinusitis | 11.41 | 9.83 | 20 | 85163 | 3593 | 56203291 |
Biliary sepsis | 11.36 | 9.83 | 10 | 85173 | 884 | 56206000 |
Joint range of motion decreased | 11.31 | 9.83 | 13 | 85170 | 25352 | 56181532 |
Presbyoesophagus | 11.30 | 9.83 | 3 | 85180 | 14 | 56206870 |
Blood pressure fluctuation | 11.24 | 9.83 | 28 | 85155 | 40332 | 56166552 |
Circulatory collapse | 11.21 | 9.83 | 9 | 85174 | 20794 | 56186090 |
Full blood count decreased | 11.21 | 9.83 | 67 | 85116 | 23282 | 56183602 |
Disturbance in attention | 11.21 | 9.83 | 86 | 85097 | 32454 | 56174430 |
Live birth | 11.19 | 9.83 | 8 | 85175 | 19597 | 56187287 |
Bezoar | 11.16 | 9.83 | 12 | 85171 | 1356 | 56205528 |
Cerebral disorder | 11.12 | 9.83 | 21 | 85162 | 3995 | 56202889 |
Ear congestion | 11.04 | 9.83 | 15 | 85168 | 2160 | 56204724 |
Atopy | 11.03 | 9.83 | 6 | 85177 | 241 | 56206643 |
Constipation | 11.00 | 9.83 | 391 | 84792 | 201552 | 56005332 |
Product quality issue | 11.00 | 9.83 | 84 | 85099 | 31652 | 56175232 |
Pneumonia | 10.90 | 9.83 | 735 | 84448 | 406363 | 55800521 |
Irritable bowel syndrome | 10.84 | 9.83 | 60 | 85123 | 68398 | 56138486 |
Burns first degree | 10.82 | 9.83 | 3 | 85180 | 17 | 56206867 |
Death | 10.79 | 9.83 | 415 | 84768 | 341011 | 55865873 |
Broad ligament tear | 10.68 | 9.83 | 3 | 85180 | 18 | 56206866 |
Hypoaesthesia | 10.65 | 9.83 | 285 | 84898 | 141206 | 56065678 |
Myxoedema coma | 10.65 | 9.83 | 7 | 85176 | 399 | 56206485 |
Ear discomfort | 10.55 | 9.83 | 29 | 85154 | 7066 | 56199818 |
Torsade de pointes | 10.53 | 9.83 | 42 | 85141 | 12398 | 56194486 |
Frustration tolerance decreased | 10.50 | 9.83 | 27 | 85156 | 6326 | 56200558 |
Post-traumatic stress disorder | 10.48 | 9.83 | 22 | 85161 | 4516 | 56202368 |
Cyclic vomiting syndrome | 10.47 | 9.83 | 4 | 85179 | 69 | 56206815 |
Patellofemoral pain syndrome | 10.46 | 9.83 | 8 | 85175 | 580 | 56206304 |
Infusion site swelling | 10.45 | 9.83 | 31 | 85152 | 7890 | 56198994 |
Multiple lentigines syndrome | 10.44 | 9.83 | 5 | 85178 | 153 | 56206731 |
Ear swelling | 10.36 | 9.83 | 11 | 85172 | 1225 | 56205659 |
Status epilepticus | 10.30 | 9.83 | 5 | 85178 | 15136 | 56191748 |
Cerumen impaction | 10.20 | 9.83 | 10 | 85173 | 1014 | 56205870 |
Myelosuppression | 10.12 | 9.83 | 7 | 85176 | 17448 | 56189436 |
Incorrect dosage administered | 10.09 | 9.83 | 13 | 85170 | 1778 | 56205106 |
Paraesthesia oral | 10.08 | 9.83 | 46 | 85137 | 14403 | 56192481 |
Hyperlipidaemia | 10.04 | 9.83 | 54 | 85129 | 18055 | 56188829 |
Drug level increased | 9.93 | 9.83 | 10 | 85173 | 20715 | 56186169 |
Defaecation urgency | 9.85 | 9.83 | 18 | 85165 | 3341 | 56203543 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Accidental exposure to product by child | 294.52 | 10.66 | 99 | 39946 | 1403 | 31655896 |
Extra dose administered | 219.17 | 10.66 | 100 | 39945 | 3300 | 31653999 |
Failure of child resistant product closure | 77.42 | 10.66 | 16 | 40029 | 21 | 31657278 |
Drug abuse | 74.58 | 10.66 | 11 | 40034 | 87747 | 31569552 |
Urticaria | 69.36 | 10.66 | 194 | 39851 | 57323 | 31599976 |
General physical health deterioration | 60.54 | 10.66 | 34 | 40011 | 113401 | 31543898 |
Rash | 55.79 | 10.66 | 440 | 39605 | 201046 | 31456253 |
Pruritus | 53.09 | 10.66 | 304 | 39741 | 124863 | 31532436 |
Infective pulmonary exacerbation of cystic fibrosis | 50.48 | 10.66 | 51 | 39994 | 6433 | 31650866 |
Off label use | 44.70 | 10.66 | 257 | 39788 | 347017 | 31310282 |
Fatigue | 43.06 | 10.66 | 627 | 39418 | 334579 | 31322720 |
Drug interaction | 41.15 | 10.66 | 131 | 39914 | 208412 | 31448887 |
Sinusitis | 38.67 | 10.66 | 118 | 39927 | 36578 | 31620721 |
Toxicity to various agents | 37.94 | 10.66 | 111 | 39934 | 181376 | 31475923 |
Completed suicide | 35.41 | 10.66 | 38 | 40007 | 91476 | 31565823 |
Asthma | 33.36 | 10.66 | 124 | 39921 | 42487 | 31614812 |
Drug ineffective | 31.91 | 10.66 | 333 | 39712 | 395240 | 31262059 |
Acute kidney injury | 30.79 | 10.66 | 217 | 39828 | 279497 | 31377802 |
Rheumatoid arthritis | 29.04 | 10.66 | 12 | 40033 | 47797 | 31609502 |
Cough | 28.67 | 10.66 | 278 | 39767 | 134536 | 31522763 |
Throat irritation | 28.50 | 10.66 | 46 | 39999 | 9268 | 31648031 |
Sinus disorder | 27.85 | 10.66 | 37 | 40008 | 6258 | 31651041 |
Swelling face | 27.60 | 10.66 | 74 | 39971 | 21316 | 31635983 |
Treatment failure | 25.16 | 10.66 | 10 | 40035 | 40782 | 31616517 |
Chronic spontaneous urticaria | 24.43 | 10.66 | 9 | 40036 | 169 | 31657130 |
Glossodynia | 23.18 | 10.66 | 25 | 40020 | 3400 | 31653899 |
Pharyngeal dystonia | 23.03 | 10.66 | 7 | 40038 | 70 | 31657229 |
Lacrimation increased | 22.95 | 10.66 | 37 | 40008 | 7445 | 31649854 |
Infusion related reaction | 22.52 | 10.66 | 120 | 39925 | 47935 | 31609364 |
Eye pruritus | 21.32 | 10.66 | 29 | 40016 | 5016 | 31652283 |
Spasmodic dysphonia | 20.93 | 10.66 | 8 | 40037 | 167 | 31657132 |
Gastrointestinal mucosal necrosis | 20.76 | 10.66 | 8 | 40037 | 171 | 31657128 |
Seasonal allergy | 20.47 | 10.66 | 30 | 40015 | 5558 | 31651741 |
Bronchitis | 20.46 | 10.66 | 100 | 39945 | 38617 | 31618682 |
Oral pruritus | 20.42 | 10.66 | 9 | 40036 | 273 | 31657026 |
Expired product administered | 20.12 | 10.66 | 22 | 40023 | 3039 | 31654260 |
Drug resistance | 19.77 | 10.66 | 3 | 40042 | 23450 | 31633849 |
CADASIL | 19.14 | 10.66 | 6 | 40039 | 67 | 31657232 |
Magnetic resonance imaging spinal abnormal | 18.83 | 10.66 | 6 | 40039 | 71 | 31657228 |
Renal impairment | 18.60 | 10.66 | 52 | 39993 | 86297 | 31571002 |
Conduction disorder | 18.58 | 10.66 | 17 | 40028 | 1897 | 31655402 |
Visual evoked potentials abnormal | 18.46 | 10.66 | 6 | 40039 | 76 | 31657223 |
Dizziness | 17.93 | 10.66 | 352 | 39693 | 198795 | 31458504 |
Interstitial lung disease | 17.26 | 10.66 | 32 | 40013 | 61371 | 31595928 |
Muscle spasms | 17.10 | 10.66 | 146 | 39899 | 68172 | 31589127 |
Lip swelling | 17.09 | 10.66 | 46 | 39999 | 13277 | 31644022 |
Central nervous system inflammation | 16.89 | 10.66 | 6 | 40039 | 101 | 31657198 |
Hyperkalaemia | 16.83 | 10.66 | 35 | 40010 | 64316 | 31592983 |
Blood pH decreased | 16.73 | 10.66 | 17 | 40028 | 2158 | 31655141 |
Nasal congestion | 16.52 | 10.66 | 60 | 39985 | 20321 | 31636978 |
PO2 increased | 16.48 | 10.66 | 10 | 40035 | 595 | 31656704 |
Chills | 16.28 | 10.66 | 154 | 39891 | 73996 | 31583303 |
Feeling abnormal | 15.98 | 10.66 | 125 | 39920 | 56877 | 31600422 |
Angioedema | 15.78 | 10.66 | 84 | 39961 | 33534 | 31623765 |
Tunnel vision | 15.71 | 10.66 | 9 | 40036 | 481 | 31656818 |
Rhabdomyolysis | 15.46 | 10.66 | 36 | 40009 | 63545 | 31593754 |
Metamorphopsia | 15.34 | 10.66 | 9 | 40036 | 503 | 31656796 |
Ejaculation delayed | 14.95 | 10.66 | 7 | 40038 | 245 | 31657054 |
Heart rate increased | 14.94 | 10.66 | 96 | 39949 | 41014 | 31616285 |
Vision blurred | 14.69 | 10.66 | 97 | 39948 | 41818 | 31615481 |
Leukopenia | 14.66 | 10.66 | 32 | 40013 | 57796 | 31599503 |
Tension headache | 14.61 | 10.66 | 13 | 40032 | 1398 | 31655901 |
Chest pain | 14.60 | 10.66 | 218 | 39827 | 116739 | 31540560 |
Rhinitis allergic | 14.55 | 10.66 | 18 | 40027 | 2836 | 31654463 |
Saccadic eye movement | 14.55 | 10.66 | 6 | 40039 | 154 | 31657145 |
Suicidal ideation | 14.47 | 10.66 | 87 | 39958 | 36319 | 31620980 |
Wheezing | 14.30 | 10.66 | 86 | 39959 | 35900 | 31621399 |
Burning sensation | 14.17 | 10.66 | 50 | 39995 | 16697 | 31640602 |
C-reactive protein increased | 13.99 | 10.66 | 25 | 40020 | 48625 | 31608674 |
Forced expiratory volume decreased | 13.95 | 10.66 | 18 | 40027 | 2959 | 31654340 |
Anxiety | 13.94 | 10.66 | 176 | 39869 | 90857 | 31566442 |
Sneezing | 13.88 | 10.66 | 23 | 40022 | 4736 | 31652563 |
Acute respiratory distress syndrome | 13.59 | 10.66 | 7 | 40038 | 24533 | 31632766 |
Insomnia | 13.54 | 10.66 | 181 | 39864 | 94655 | 31562644 |
Cerebral microangiopathy | 13.52 | 10.66 | 6 | 40039 | 185 | 31657114 |
Upper respiratory tract infection | 13.46 | 10.66 | 73 | 39972 | 29349 | 31627950 |
Muscle tightness | 13.35 | 10.66 | 22 | 40023 | 4507 | 31652792 |
Pneumonitis | 13.32 | 10.66 | 75 | 39970 | 30577 | 31626722 |
Double stranded DNA antibody positive | 13.17 | 10.66 | 6 | 40039 | 197 | 31657102 |
Intercepted medication error | 13.05 | 10.66 | 8 | 40037 | 485 | 31656814 |
Oropharyngeal pain | 13.00 | 10.66 | 76 | 39969 | 31407 | 31625892 |
Pneumonia | 12.96 | 10.66 | 532 | 39513 | 334780 | 31322519 |
Gastrooesophageal reflux disease | 12.86 | 10.66 | 80 | 39965 | 33791 | 31623508 |
Hyponatraemia | 12.74 | 10.66 | 49 | 39996 | 73750 | 31583549 |
Foetal exposure during pregnancy | 12.68 | 10.66 | 20 | 40025 | 40856 | 31616443 |
Lactic acidosis | 12.63 | 10.66 | 13 | 40032 | 31924 | 31625375 |
Mucosal inflammation | 12.54 | 10.66 | 15 | 40030 | 34412 | 31622887 |
Renal failure | 12.41 | 10.66 | 98 | 39947 | 123232 | 31534067 |
Skin warm | 12.35 | 10.66 | 14 | 40031 | 2012 | 31655287 |
Cytomegalovirus infection | 12.33 | 10.66 | 8 | 40037 | 24699 | 31632600 |
Testicular cyst | 12.28 | 10.66 | 4 | 40041 | 51 | 31657248 |
Sleep apnoea syndrome | 11.99 | 10.66 | 51 | 39994 | 18574 | 31638725 |
Contraindicated product administered | 11.94 | 10.66 | 5 | 40040 | 19767 | 31637532 |
Rhinorrhoea | 11.84 | 10.66 | 59 | 39986 | 22953 | 31634346 |
Upper-airway cough syndrome | 11.76 | 10.66 | 17 | 40028 | 3110 | 31654189 |
Migraine | 11.71 | 10.66 | 42 | 40003 | 14138 | 31643161 |
Headache | 11.63 | 10.66 | 309 | 39736 | 183343 | 31473956 |
Cardiogenic shock | 11.53 | 10.66 | 7 | 40038 | 22401 | 31634898 |
Depression | 11.22 | 10.66 | 169 | 39876 | 90646 | 31566653 |
Oral viral infection | 11.21 | 10.66 | 3 | 40042 | 18 | 31657281 |
Crying | 11.20 | 10.66 | 23 | 40022 | 5574 | 31651725 |
Convulsions local | 11.07 | 10.66 | 3 | 40042 | 19 | 31657280 |
Spinal osteoarthritis | 11.05 | 10.66 | 26 | 40019 | 6909 | 31650390 |
Eosinophilia | 10.98 | 10.66 | 8 | 40037 | 23245 | 31634054 |
Physical examination abnormal | 10.97 | 10.66 | 6 | 40039 | 293 | 31657006 |
Drug level increased | 10.83 | 10.66 | 6 | 40039 | 20180 | 31637119 |
Thrombocytopenia | 10.70 | 10.66 | 122 | 39923 | 142625 | 31514674 |
Rash pruritic | 10.68 | 10.66 | 59 | 39986 | 23879 | 31633420 |
Blood cholesterol increased | 10.68 | 10.66 | 46 | 39999 | 16847 | 31640452 |
Agitation | 10.66 | 10.66 | 110 | 39935 | 54059 | 31603240 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Extra dose administered | 531.37 | 9.76 | 240 | 97926 | 7037 | 70823241 |
Accidental exposure to product by child | 457.63 | 9.76 | 165 | 98001 | 2641 | 70827637 |
Failure of child resistant product closure | 192.34 | 9.76 | 39 | 98127 | 36 | 70830242 |
Urticaria | 177.04 | 9.76 | 562 | 97604 | 162487 | 70667791 |
Rheumatoid arthritis | 159.23 | 9.76 | 104 | 98062 | 291701 | 70538577 |
Drug ineffective | 138.74 | 9.76 | 751 | 97415 | 939001 | 69891277 |
Gastrooesophageal reflux disease | 138.46 | 9.76 | 354 | 97812 | 90485 | 70739793 |
Drug abuse | 130.79 | 9.76 | 23 | 98143 | 147233 | 70683045 |
Off label use | 127.32 | 9.76 | 563 | 97603 | 742497 | 70087781 |
Synovitis | 119.65 | 9.76 | 18 | 98148 | 129210 | 70701068 |
Contraindicated product administered | 117.44 | 9.76 | 22 | 98144 | 134590 | 70695688 |
General physical health deterioration | 115.86 | 9.76 | 94 | 98072 | 235937 | 70594341 |
Pruritus | 108.12 | 9.76 | 833 | 97333 | 344727 | 70485551 |
Infective pulmonary exacerbation of cystic fibrosis | 100.48 | 9.76 | 103 | 98063 | 12055 | 70818223 |
Treatment failure | 100.29 | 9.76 | 37 | 98129 | 144105 | 70686173 |
Toxicity to various agents | 96.57 | 9.76 | 244 | 97922 | 381928 | 70448350 |
Drug intolerance | 95.31 | 9.76 | 103 | 98063 | 225584 | 70604694 |
Swelling face | 94.00 | 9.76 | 244 | 97922 | 62920 | 70767358 |
Hand deformity | 87.47 | 9.76 | 9 | 98157 | 86473 | 70743805 |
Somnolence | 78.99 | 9.76 | 540 | 97626 | 215066 | 70615212 |
Joint swelling | 77.70 | 9.76 | 145 | 98021 | 253066 | 70577212 |
Acute kidney injury | 77.26 | 9.76 | 366 | 97800 | 474258 | 70356020 |
Asthma | 75.95 | 9.76 | 350 | 97816 | 120443 | 70709835 |
Dizziness | 70.21 | 9.76 | 964 | 97202 | 463177 | 70367101 |
Therapeutic product effect decreased | 70.08 | 9.76 | 57 | 98109 | 142961 | 70687317 |
Pneumonia aspiration | 64.15 | 9.76 | 211 | 97955 | 62078 | 70768200 |
Lip swelling | 64.01 | 9.76 | 144 | 98022 | 33910 | 70796368 |
Pericarditis | 63.71 | 9.76 | 19 | 98147 | 84686 | 70745592 |
Systemic lupus erythematosus | 58.72 | 9.76 | 34 | 98132 | 101868 | 70728410 |
C-reactive protein increased | 58.04 | 9.76 | 41 | 98125 | 110476 | 70719802 |
Wound | 56.81 | 9.76 | 33 | 98133 | 98699 | 70731579 |
Angioedema | 56.80 | 9.76 | 212 | 97954 | 66398 | 70763880 |
Arthropathy | 56.38 | 9.76 | 75 | 98091 | 149982 | 70680296 |
Butterfly rash | 56.27 | 9.76 | 31 | 98135 | 1399 | 70828879 |
Glossodynia | 52.54 | 9.76 | 27 | 98139 | 86460 | 70743818 |
Drug interaction | 52.07 | 9.76 | 312 | 97854 | 381129 | 70449149 |
Headache | 50.48 | 9.76 | 1103 | 97063 | 579302 | 70250976 |
Cholecystitis chronic | 49.53 | 9.76 | 63 | 98103 | 9313 | 70820965 |
Muscle spasms | 49.53 | 9.76 | 374 | 97792 | 153672 | 70676606 |
Rash | 49.52 | 9.76 | 986 | 97180 | 509576 | 70320702 |
Feeling abnormal | 48.88 | 9.76 | 351 | 97815 | 141968 | 70688310 |
Helicobacter infection | 48.73 | 9.76 | 9 | 98157 | 55647 | 70774631 |
Cough | 47.97 | 9.76 | 673 | 97493 | 324704 | 70505574 |
Throat irritation | 47.09 | 9.76 | 131 | 98035 | 35173 | 70795105 |
Insomnia | 45.84 | 9.76 | 482 | 97684 | 217324 | 70612954 |
Emotional distress | 45.72 | 9.76 | 134 | 98032 | 37054 | 70793224 |
Anxiety | 45.63 | 9.76 | 486 | 97680 | 219844 | 70610434 |
Dyspnoea | 44.97 | 9.76 | 1388 | 96778 | 768672 | 70061606 |
Fatigue | 44.55 | 9.76 | 1472 | 96694 | 822847 | 70007431 |
Palpitations | 43.89 | 9.76 | 283 | 97883 | 110470 | 70719808 |
Chest discomfort | 42.84 | 9.76 | 307 | 97859 | 124074 | 70706204 |
Chest pain | 41.68 | 9.76 | 531 | 97635 | 250729 | 70579549 |
Completed suicide | 41.20 | 9.76 | 168 | 97998 | 226967 | 70603311 |
Expired product administered | 40.22 | 9.76 | 47 | 98119 | 6366 | 70823912 |
Nasal congestion | 39.57 | 9.76 | 188 | 97978 | 65484 | 70764794 |
Renal impairment | 39.38 | 9.76 | 88 | 98078 | 143849 | 70686429 |
C-reactive protein abnormal | 39.04 | 9.76 | 4 | 98162 | 38575 | 70791703 |
Product dose omission issue | 38.83 | 9.76 | 466 | 97700 | 217002 | 70613276 |
Sinusitis | 38.25 | 9.76 | 380 | 97786 | 168815 | 70661463 |
Rhabdomyolysis | 36.85 | 9.76 | 47 | 98119 | 95713 | 70734565 |
Rhinitis allergic | 36.34 | 9.76 | 54 | 98112 | 9241 | 70821037 |
Bronchitis | 36.19 | 9.76 | 282 | 97884 | 116961 | 70713317 |
Dermatitis atopic | 36.18 | 9.76 | 53 | 98113 | 8954 | 70821324 |
Eye pruritus | 35.80 | 9.76 | 69 | 98097 | 14578 | 70815700 |
Tinnitus | 34.99 | 9.76 | 120 | 98046 | 36056 | 70794222 |
Pancytopenia | 34.68 | 9.76 | 101 | 98065 | 151006 | 70679272 |
Drug resistance | 33.81 | 9.76 | 6 | 98160 | 38184 | 70792094 |
Vision blurred | 33.61 | 9.76 | 236 | 97930 | 94748 | 70735530 |
Sleep disorder due to general medical condition, insomnia type | 33.01 | 9.76 | 5 | 98161 | 35727 | 70794551 |
Hyperkalaemia | 32.69 | 9.76 | 61 | 98105 | 106530 | 70723748 |
Maternal exposure during pregnancy | 31.97 | 9.76 | 70 | 98096 | 115275 | 70715003 |
Thrombocytopenia | 30.81 | 9.76 | 199 | 97967 | 238911 | 70591367 |
Gallbladder disorder | 30.10 | 9.76 | 72 | 98094 | 17640 | 70812638 |
Folliculitis | 29.47 | 9.76 | 11 | 98155 | 42559 | 70787719 |
Oropharyngeal pain | 28.81 | 9.76 | 230 | 97936 | 96080 | 70734198 |
Hepatocellular injury | 28.57 | 9.76 | 14 | 98152 | 46077 | 70784201 |
Hepatic enzyme increased | 27.91 | 9.76 | 117 | 98049 | 156873 | 70673405 |
Chronic spontaneous urticaria | 27.82 | 9.76 | 18 | 98148 | 1093 | 70829185 |
Multiple organ dysfunction syndrome | 27.55 | 9.76 | 69 | 98097 | 108446 | 70721832 |
Sopor | 27.49 | 9.76 | 5 | 98161 | 31262 | 70799016 |
Upper respiratory tract infection | 27.48 | 9.76 | 196 | 97970 | 79078 | 70751200 |
Allergy test positive | 27.23 | 9.76 | 13 | 98153 | 433 | 70829845 |
Coma | 26.75 | 9.76 | 218 | 97948 | 91626 | 70738652 |
Burning sensation | 26.69 | 9.76 | 144 | 98022 | 52726 | 70777552 |
Head discomfort | 26.66 | 9.76 | 57 | 98109 | 12966 | 70817312 |
Cytomegalovirus infection | 26.33 | 9.76 | 11 | 98155 | 39747 | 70790531 |
Lower respiratory tract infection | 26.26 | 9.76 | 74 | 98092 | 111839 | 70718439 |
Therapeutic product effect incomplete | 26.16 | 9.76 | 82 | 98084 | 119800 | 70710478 |
Chills | 25.71 | 9.76 | 310 | 97856 | 144476 | 70685802 |
Infection | 25.36 | 9.76 | 179 | 97987 | 210606 | 70619672 |
Lactic acidosis | 24.92 | 9.76 | 32 | 98134 | 64992 | 70765286 |
Swollen tongue | 24.50 | 9.76 | 109 | 98057 | 36937 | 70793341 |
Incorrect dose administered | 24.32 | 9.76 | 167 | 97999 | 66552 | 70763726 |
Mobility decreased | 24.25 | 9.76 | 68 | 98098 | 102931 | 70727347 |
Status asthmaticus | 24.24 | 9.76 | 16 | 98150 | 1005 | 70829273 |
Photosensitivity reaction | 24.07 | 9.76 | 70 | 98096 | 19270 | 70811008 |
Sinus disorder | 23.96 | 9.76 | 69 | 98097 | 18890 | 70811388 |
Migraine | 23.54 | 9.76 | 176 | 97990 | 72062 | 70758216 |
Cardiac failure | 23.09 | 9.76 | 111 | 98055 | 143430 | 70686848 |
Renal failure | 23.02 | 9.76 | 160 | 98006 | 188910 | 70641368 |
Intentional product use issue | 22.96 | 9.76 | 87 | 98079 | 120055 | 70710223 |
Depression | 22.94 | 9.76 | 395 | 97771 | 198579 | 70631699 |
Interstitial lung disease | 22.57 | 9.76 | 72 | 98094 | 104613 | 70725665 |
Leukopenia | 22.48 | 9.76 | 74 | 98092 | 106486 | 70723792 |
Injury | 22.43 | 9.76 | 161 | 98005 | 65084 | 70765194 |
Deep vein thrombosis | 22.06 | 9.76 | 243 | 97923 | 110799 | 70719479 |
Seasonal allergy | 22.04 | 9.76 | 54 | 98112 | 13430 | 70816848 |
Wheezing | 21.99 | 9.76 | 213 | 97953 | 93957 | 70736321 |
Periorbital oedema | 21.98 | 9.76 | 39 | 98127 | 7736 | 70822542 |
Musculoskeletal stiffness | 21.65 | 9.76 | 118 | 98048 | 147642 | 70682636 |
Septic shock | 21.64 | 9.76 | 81 | 98085 | 112177 | 70718101 |
Throat tightness | 21.62 | 9.76 | 80 | 98086 | 24942 | 70805336 |
Malignant neoplasm progression | 21.46 | 9.76 | 91 | 98075 | 121648 | 70708630 |
Anaphylactic reaction | 21.31 | 9.76 | 177 | 97989 | 74797 | 70755481 |
Drug level increased | 21.24 | 9.76 | 12 | 98154 | 36457 | 70793821 |
Acute respiratory distress syndrome | 20.75 | 9.76 | 16 | 98150 | 41238 | 70789040 |
Red blood cell sedimentation rate increased | 20.73 | 9.76 | 14 | 98152 | 38628 | 70791650 |
Oral pruritus | 20.61 | 9.76 | 19 | 98147 | 1952 | 70828326 |
Hepatic failure | 20.43 | 9.76 | 30 | 98136 | 57595 | 70772683 |
Knee arthroplasty | 20.40 | 9.76 | 11 | 98155 | 34290 | 70795988 |
Discomfort | 20.37 | 9.76 | 76 | 98090 | 105360 | 70724918 |
Gallbladder injury | 20.22 | 9.76 | 15 | 98151 | 1137 | 70829141 |
Crying | 20.22 | 9.76 | 70 | 98096 | 21129 | 70809149 |
Circulatory collapse | 20.20 | 9.76 | 12 | 98154 | 35462 | 70794816 |
Feeling hot | 19.66 | 9.76 | 125 | 98041 | 48545 | 70781733 |
Overdose | 19.52 | 9.76 | 146 | 98020 | 169599 | 70660679 |
Product quality issue | 19.52 | 9.76 | 89 | 98077 | 30472 | 70799806 |
Lacrimation increased | 19.23 | 9.76 | 66 | 98100 | 19833 | 70810445 |
Dry skin | 19.21 | 9.76 | 138 | 98028 | 55793 | 70774485 |
Back pain | 19.12 | 9.76 | 501 | 97665 | 270651 | 70559627 |
Impaired healing | 19.11 | 9.76 | 47 | 98119 | 74327 | 70755951 |
Psoriatic arthropathy | 19.04 | 9.76 | 38 | 98128 | 64733 | 70765545 |
Bone marrow failure | 18.91 | 9.76 | 24 | 98142 | 48986 | 70781292 |
Gastrointestinal mucosal necrosis | 18.70 | 9.76 | 8 | 98158 | 205 | 70830073 |
Cystitis noninfective | 18.70 | 9.76 | 15 | 98151 | 1276 | 70829002 |
Nervousness | 18.68 | 9.76 | 89 | 98077 | 31031 | 70799247 |
Agranulocytosis | 18.58 | 9.76 | 17 | 98149 | 40281 | 70789997 |
Urinary tract infection | 17.93 | 9.76 | 461 | 97705 | 248308 | 70581970 |
Bone pain | 17.81 | 9.76 | 126 | 98040 | 50696 | 70779582 |
Hypotension | 17.78 | 9.76 | 425 | 97741 | 403956 | 70426322 |
Acquired haemophilia | 17.69 | 9.76 | 17 | 98149 | 1840 | 70828438 |
Incorrect dosage administered | 17.68 | 9.76 | 19 | 98147 | 2348 | 70827930 |
Biliary dyskinesia | 17.47 | 9.76 | 19 | 98147 | 2380 | 70827898 |
Sinus headache | 17.33 | 9.76 | 26 | 98140 | 4487 | 70825791 |
Hyponatraemia | 17.33 | 9.76 | 140 | 98026 | 159947 | 70670331 |
Upper-airway cough syndrome | 17.01 | 9.76 | 40 | 98126 | 9691 | 70820587 |
Heart rate increased | 17.01 | 9.76 | 223 | 97943 | 105925 | 70724353 |
Hypersomnia | 16.80 | 9.76 | 65 | 98101 | 20699 | 70809579 |
Paraesthesia | 16.80 | 9.76 | 289 | 97877 | 145248 | 70685030 |
Allergic cystitis | 16.75 | 9.76 | 3 | 98163 | 0 | 70830278 |
Transient ischaemic attack | 16.74 | 9.76 | 115 | 98051 | 45829 | 70784449 |
Nausea | 16.71 | 9.76 | 1382 | 96784 | 850706 | 69979572 |
Cerebral haemorrhage | 16.36 | 9.76 | 31 | 98135 | 53833 | 70776445 |
Erythema | 16.23 | 9.76 | 376 | 97790 | 199187 | 70631091 |
Myelosuppression | 16.06 | 9.76 | 11 | 98155 | 30134 | 70800144 |
Eye swelling | 16.01 | 9.76 | 70 | 98096 | 23544 | 70806734 |
Osteonecrosis of jaw | 15.90 | 9.76 | 20 | 98146 | 40982 | 70789296 |
Status epilepticus | 15.90 | 9.76 | 7 | 98159 | 24519 | 70805759 |
Transplant rejection | 15.77 | 9.76 | 3 | 98163 | 18168 | 70812110 |
Emotional disorder | 15.63 | 9.76 | 47 | 98119 | 13179 | 70817099 |
Hepatotoxicity | 15.50 | 9.76 | 23 | 98143 | 43963 | 70786315 |
Blood pressure fluctuation | 15.39 | 9.76 | 37 | 98129 | 58975 | 70771303 |
Thrombotic microangiopathy | 15.38 | 9.76 | 3 | 98163 | 17845 | 70812433 |
Pulmonary fibrosis | 15.21 | 9.76 | 15 | 98151 | 34295 | 70795983 |
Cystoid macular oedema | 15.16 | 9.76 | 16 | 98150 | 1936 | 70828342 |
Red blood cell sedimentation rate abnormal | 15.12 | 9.76 | 4 | 98162 | 19299 | 70810979 |
Eczema | 15.06 | 9.76 | 89 | 98077 | 33692 | 70796586 |
Flushing | 15.04 | 9.76 | 177 | 97989 | 81995 | 70748283 |
Altered state of consciousness | 15.02 | 9.76 | 20 | 98146 | 40002 | 70790276 |
Pneumonia | 14.87 | 9.76 | 986 | 97180 | 595246 | 70235032 |
Cardiogenic shock | 14.83 | 9.76 | 17 | 98149 | 36290 | 70793988 |
Initial insomnia | 14.54 | 9.76 | 29 | 98137 | 6280 | 70823998 |
Swelling | 14.51 | 9.76 | 179 | 97987 | 188360 | 70641918 |
Alopecia | 14.33 | 9.76 | 191 | 97975 | 198299 | 70631979 |
Condition aggravated | 14.29 | 9.76 | 467 | 97699 | 427168 | 70403110 |
Posterior reversible encephalopathy syndrome | 14.25 | 9.76 | 8 | 98158 | 24394 | 70805884 |
Hyperlipidaemia | 14.14 | 9.76 | 68 | 98098 | 23795 | 70806483 |
Polyneuropathy | 14.06 | 9.76 | 6 | 98160 | 21409 | 70808869 |
Dry mouth | 13.90 | 9.76 | 154 | 98012 | 70303 | 70759975 |
Therapy non-responder | 13.86 | 9.76 | 57 | 98109 | 76858 | 70753420 |
Carotid artery disease | 13.63 | 9.76 | 16 | 98150 | 2177 | 70828101 |
Administration site inflammation | 13.47 | 9.76 | 3 | 98163 | 6 | 70830272 |
Victim of chemical submission | 13.42 | 9.76 | 8 | 98158 | 420 | 70829858 |
Syncope | 13.41 | 9.76 | 312 | 97854 | 165397 | 70664881 |
Autoimmune hepatitis | 13.38 | 9.76 | 39 | 98127 | 10747 | 70819531 |
Burns first degree | 13.38 | 9.76 | 4 | 98162 | 34 | 70830244 |
Full blood count decreased | 13.35 | 9.76 | 67 | 98099 | 23851 | 70806427 |
Panic disorder | 13.20 | 9.76 | 18 | 98148 | 2846 | 70827432 |
Oesophageal adenocarcinoma recurrent | 13.18 | 9.76 | 4 | 98162 | 36 | 70830242 |
Heart rate decreased | 13.12 | 9.76 | 43 | 98123 | 61972 | 70768306 |
Pulmonary embolism | 13.09 | 9.76 | 295 | 97871 | 155572 | 70674706 |
Illness | 13.06 | 9.76 | 82 | 98084 | 31709 | 70798569 |
Face oedema | 13.05 | 9.76 | 70 | 98096 | 25569 | 70804709 |
Mast cell activation syndrome | 12.89 | 9.76 | 9 | 98157 | 620 | 70829658 |
Skin exfoliation | 12.87 | 9.76 | 113 | 98053 | 48513 | 70781765 |
Bronchial hyperreactivity | 12.86 | 9.76 | 17 | 98149 | 2609 | 70827669 |
Multiple lentigines syndrome | 12.73 | 9.76 | 6 | 98160 | 194 | 70830084 |
Patellofemoral pain syndrome | 12.71 | 9.76 | 8 | 98158 | 463 | 70829815 |
Palmar erythema | 12.64 | 9.76 | 14 | 98152 | 1789 | 70828489 |
Visual impairment | 12.61 | 9.76 | 168 | 97998 | 80082 | 70750196 |
Hypoaesthesia | 12.60 | 9.76 | 290 | 97876 | 153449 | 70676829 |
Reversible cerebral vasoconstriction syndrome | 12.57 | 9.76 | 17 | 98149 | 2668 | 70827610 |
Breast pain | 12.56 | 9.76 | 30 | 98136 | 7341 | 70822937 |
Exposure to toxic agent | 12.55 | 9.76 | 27 | 98139 | 6167 | 70824111 |
Gastrointestinal disorder | 12.44 | 9.76 | 90 | 98076 | 105337 | 70724941 |
Chronic obstructive pulmonary disease | 12.39 | 9.76 | 163 | 98003 | 77478 | 70752800 |
Pneumocystis jirovecii pneumonia | 12.38 | 9.76 | 14 | 98152 | 30068 | 70800210 |
Suicidal ideation | 12.34 | 9.76 | 149 | 98017 | 69447 | 70760831 |
Sinus congestion | 12.16 | 9.76 | 52 | 98114 | 17321 | 70812957 |
Pharyngeal dystonia | 12.14 | 9.76 | 4 | 98162 | 48 | 70830230 |
Rash pruritic | 12.12 | 9.76 | 137 | 98029 | 62854 | 70767424 |
Haemophagocytic lymphohistiocytosis | 12.09 | 9.76 | 6 | 98160 | 19606 | 70810672 |
Conduction disorder | 12.02 | 9.76 | 18 | 98148 | 3100 | 70827178 |
Tinea pedis | 11.99 | 9.76 | 15 | 98151 | 2181 | 70828097 |
Melaena | 11.97 | 9.76 | 39 | 98127 | 56316 | 70773962 |
Neuroleptic malignant syndrome | 11.96 | 9.76 | 11 | 98155 | 25996 | 70804282 |
Neurological examination abnormal | 11.90 | 9.76 | 8 | 98158 | 518 | 70829760 |
Coronary artery disease | 11.87 | 9.76 | 136 | 98030 | 62600 | 70767678 |
Basophil count decreased | 11.86 | 9.76 | 6 | 98160 | 227 | 70830051 |
Mitral valve prolapse | 11.79 | 9.76 | 14 | 98152 | 1929 | 70828349 |
Medication error | 11.67 | 9.76 | 40 | 98126 | 56872 | 70773406 |
Allergy to animal | 11.66 | 9.76 | 11 | 98155 | 1164 | 70829114 |
Intervertebral disc degeneration | 11.64 | 9.76 | 44 | 98122 | 13856 | 70816422 |
Laryngeal pain | 11.64 | 9.76 | 25 | 98141 | 5703 | 70824575 |
Hepatic cytolysis | 11.64 | 9.76 | 6 | 98160 | 19186 | 70811092 |
Depressed level of consciousness | 11.64 | 9.76 | 72 | 98094 | 87359 | 70742919 |
Lethargy | 11.60 | 9.76 | 157 | 98009 | 75093 | 70755185 |
Non-cardiac chest pain | 11.58 | 9.76 | 33 | 98133 | 8982 | 70821296 |
Ill-defined disorder | 11.55 | 9.76 | 38 | 98128 | 54703 | 70775575 |
Cholelithiasis | 11.51 | 9.76 | 108 | 98058 | 47232 | 70783046 |
Paraesthesia oral | 11.46 | 9.76 | 47 | 98119 | 15370 | 70814908 |
Bronchospasm | 11.45 | 9.76 | 62 | 98104 | 22730 | 70807548 |
Ventricular hypertrophy | 11.44 | 9.76 | 27 | 98139 | 6557 | 70823721 |
Ear congestion | 11.30 | 9.76 | 15 | 98151 | 2312 | 70827966 |
Mood altered | 11.29 | 9.76 | 49 | 98117 | 16426 | 70813852 |
Rotator cuff syndrome | 11.24 | 9.76 | 41 | 98125 | 12693 | 70817585 |
Respiratory failure | 11.24 | 9.76 | 165 | 98001 | 168570 | 70661708 |
Essential hypertension | 11.22 | 9.76 | 24 | 98142 | 5460 | 70824818 |
Skin burning sensation | 11.13 | 9.76 | 38 | 98128 | 11388 | 70818890 |
Dyspepsia | 11.05 | 9.76 | 179 | 97987 | 88898 | 70741380 |
Ear infection | 10.97 | 9.76 | 72 | 98094 | 28264 | 70802014 |
Nephropathy toxic | 10.92 | 9.76 | 6 | 98160 | 18508 | 70811770 |
Rhinorrhoea | 10.87 | 9.76 | 140 | 98026 | 66231 | 70764047 |
Liver disorder | 10.86 | 9.76 | 46 | 98120 | 61522 | 70768756 |
Anuria | 10.70 | 9.76 | 7 | 98159 | 19646 | 70810632 |
Cerebrovascular accident | 10.66 | 9.76 | 267 | 97899 | 143203 | 70687075 |
Blood pressure diastolic decreased | 10.61 | 9.76 | 12 | 98154 | 25768 | 70804510 |
Dysgeusia | 10.60 | 9.76 | 110 | 98056 | 49392 | 70780886 |
Neutropenia | 10.54 | 9.76 | 273 | 97893 | 256883 | 70573395 |
Hip arthroplasty | 10.54 | 9.76 | 14 | 98152 | 28026 | 70802252 |
Pain in extremity | 10.52 | 9.76 | 555 | 97611 | 327527 | 70502751 |
Otitis media | 10.48 | 9.76 | 24 | 98142 | 5715 | 70824563 |
Accident at home | 10.46 | 9.76 | 5 | 98161 | 167 | 70830111 |
Blister | 10.38 | 9.76 | 89 | 98077 | 100437 | 70729841 |
Infusion site swelling | 10.32 | 9.76 | 25 | 98141 | 6173 | 70824105 |
Uterine cyst | 10.31 | 9.76 | 6 | 98160 | 301 | 70829977 |
Temperature intolerance | 10.31 | 9.76 | 31 | 98135 | 8692 | 70821586 |
Hypertensive crisis | 10.30 | 9.76 | 7 | 98159 | 19255 | 70811023 |
Bacterial test positive | 10.29 | 9.76 | 27 | 98139 | 7004 | 70823274 |
Loss of personal independence in daily activities | 10.25 | 9.76 | 72 | 98094 | 84838 | 70745440 |
Intercepted medication error | 10.25 | 9.76 | 9 | 98157 | 868 | 70829410 |
Delirium | 10.16 | 9.76 | 61 | 98105 | 74553 | 70755725 |
Skin necrosis | 10.02 | 9.76 | 5 | 98161 | 16286 | 70813992 |
Tuberculosis | 10.01 | 9.76 | 4 | 98162 | 14844 | 70815434 |
Oral viral infection | 10.00 | 9.76 | 4 | 98162 | 86 | 70830192 |
Rhinovirus infection | 10.00 | 9.76 | 26 | 98140 | 6707 | 70823571 |
Death | 9.98 | 9.76 | 591 | 97575 | 509470 | 70320808 |
Sinus operation | 9.94 | 9.76 | 13 | 98153 | 1974 | 70828304 |
Cellulitis | 9.85 | 9.76 | 192 | 97974 | 98736 | 70731542 |
Blood creatinine increased | 9.82 | 9.76 | 139 | 98027 | 142862 | 70687416 |
Nasal discomfort | 9.81 | 9.76 | 21 | 98145 | 4780 | 70825498 |
Aphthous ulcer | 9.79 | 9.76 | 4 | 98162 | 14652 | 70815626 |
Testicular cyst | 9.79 | 9.76 | 3 | 98163 | 28 | 70830250 |
Cataract subcapsular | 9.78 | 9.76 | 9 | 98157 | 922 | 70829356 |
None
Source | Code | Description |
---|---|---|
ATC | R06AX13 | RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Other antihistamines for systemic use |
CHEBI has role | CHEBI:37955 | H1 receptor antagonists |
CHEBI has role | CHEBI:48873 | acetylcholine receptor antagonist |
CHEBI has role | CHEBI:50857 | anti-allergic drugs |
CHEBI has role | CHEBI:176497 | geroprotectors |
MeSH PA | D018926 | Anti-Allergic Agents |
MeSH PA | D000982 | Antipruritics |
MeSH PA | D003879 | Dermatologic Agents |
MeSH PA | D018494 | Histamine Agents |
MeSH PA | D006633 | Histamine Antagonists |
MeSH PA | D006634 | Histamine H1 Antagonists |
MeSH PA | D039563 | Histamine H1 Antagonists, Non-Sedating |
MeSH PA | D018377 | Neurotransmitter Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Vasomotor rhinitis | indication | 8229003 | DOID:4730 |
Allergic rhinitis | indication | 61582004 | |
Nasal discharge | indication | 64531003 | |
Nasal congestion | indication | 68235000 | |
Sneezing | indication | 76067001 | |
Common cold | indication | 82272006 | DOID:10459 |
Chronic idiopathic urticaria | indication | 302162004 | |
Seasonal allergic rhinitis | indication | 367498001 | |
Allergic conjunctivitis | indication | 473460002 | DOID:11204 |
Bone pain after neupogen | off-label use | 12584003 | |
Urticaria | off-label use | 126485001 | |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Coronary arteriosclerosis | contraindication | 53741008 | DOID:3393 |
Hepatic failure | contraindication | 59927004 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Impaired renal function disorder | contraindication | 197663003 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Retention of urine | contraindication | 267064002 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Hypertensive urgency | contraindication | 443482000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 4.43 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Histamine H1 receptor | GPCR | ANTAGONIST | Ki | 6.97 | WOMBAT-PK | CHEMBL | |||
Multidrug resistance protein 1 | Transporter | Ki | 4.94 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 2B | GPCR | Ki | 6.81 | DRUG MATRIX | |||||
Nuclear receptor subfamily 1 group I member 2 | Nuclear hormone receptor | EC50 | 5.52 | CHEMBL | |||||
Cytochrome P450 2C19 | Enzyme | IC50 | 7.80 | DRUG MATRIX | |||||
Potassium channel subfamily K member 9 | Ion channel | IC50 | 4.20 | CHEMBL | |||||
Bile acid receptor | Nuclear hormone receptor | IC50 | 5.51 | CHEMBL | |||||
Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 6.77 | WOMBAT-PK | |||||
Sodium-dependent neutral amino acid transporter B(0)AT2 | Transporter | IC50 | 5.40 | CHEMBL | |||||
Histamine H1 receptor | GPCR | Kd | 7.14 | CHEMBL | |||||
Histamine H1 receptor | GPCR | Ki | 6.46 | CHEMBL |
ID | Source |
---|---|
4020716 | VUID |
N0000148306 | NUI |
D00364 | KEGG_DRUG |
4020716 | VANDF |
C0065180 | UMLSCUI |
CHEBI:6538 | CHEBI |
CHEMBL998 | ChEMBL_ID |
DB00455 | DRUGBANK_ID |
D017336 | MESH_DESCRIPTOR_UI |
3957 | PUBCHEM_CID |
7216 | IUPHAR_LIGAND_ID |
5864 | INN_ID |
7AJO3BO7QN | UNII |
203576 | RXNORM |
191 | MMSL |
45829 | MMSL |
4994 | MMSL |
d03050 | MMSL |
003909 | NDDF |
015760 | NDDF |
108652002 | SNOMEDCT_US |
386884002 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
allergy relief | HUMAN OTC DRUG LABEL | 1 | 0067-6066 | TABLET | 10 mg | ORAL | NDA | 15 sections |
allergy relief | HUMAN OTC DRUG LABEL | 1 | 0067-6122 | TABLET | 10 mg | ORAL | NDA | 15 sections |
good sense allergy relief | HUMAN OTC DRUG LABEL | 1 | 0113-0612 | TABLET | 10 mg | ORAL | ANDA | 15 sections |
Good Sense childrens allergy relief | HUMAN OTC DRUG LABEL | 1 | 0113-0671 | SOLUTION | 5 mg | ORAL | ANDA | 14 sections |
good sense childrens allergy relief | HUMAN OTC DRUG LABEL | 1 | 0113-1019 | TABLET, CHEWABLE | 5 mg | ORAL | ANDA | 15 sections |
good sense allergy relief | HUMAN OTC DRUG LABEL | 1 | 0113-1191 | TABLET, ORALLY DISINTEGRATING | 10 mg | ORAL | ANDA | 15 sections |
good sense allergy relief | HUMAN OTC DRUG LABEL | 1 | 0113-1612 | TABLET | 10 mg | ORAL | ANDA | 15 sections |
good sense childrens allergy relief | HUMAN OTC DRUG LABEL | 1 | 0113-1719 | SOLUTION | 5 mg | ORAL | ANDA | 14 sections |
Allergy and Congestion Relief | HUMAN OTC DRUG LABEL | 2 | 0113-2007 | TABLET, FILM COATED, EXTENDED RELEASE | 5 mg | ORAL | ANDA | 14 sections |
basic care childrens allergy relief | HUMAN OTC DRUG LABEL | 1 | 0113-7500 | TABLET, CHEWABLE | 5 mg | ORAL | ANDA | 15 sections |
basic care childrens allergy relief | HUMAN OTC DRUG LABEL | 1 | 0113-7500 | TABLET, CHEWABLE | 5 mg | ORAL | ANDA | 15 sections |
Basic Care allergy relief | HUMAN OTC DRUG LABEL | 1 | 0113-7612 | TABLET | 10 mg | ORAL | ANDA | 15 sections |
Basic Care Childrens Allergy Relief | HUMAN OTC DRUG LABEL | 1 | 0113-7671 | SOLUTION | 5 mg | ORAL | ANDA | 14 sections |
perrigo allergy d | HUMAN OTC DRUG LABEL | 2 | 0113-7777 | TABLET, FILM COATED, EXTENDED RELEASE | 5 mg | ORAL | ANDA | 15 sections |
good sense allergy relief | HUMAN OTC DRUG LABEL | 1 | 0113-9755 | TABLET, ORALLY DISINTEGRATING | 10 mg | ORAL | ANDA | 15 sections |
Childrens Loratadine | HUMAN OTC DRUG LABEL | 1 | 0121-0849 | SOLUTION | 5 mg | ORAL | ANDA | 16 sections |
Childrens Loratadine | HUMAN OTC DRUG LABEL | 1 | 0121-0849 | SOLUTION | 5 mg | ORAL | ANDA | 16 sections |
Loratadine | HUMAN OTC DRUG LABEL | 1 | 0363-0522 | TABLET | 10 mg | ORAL | ANDA | 15 sections |
Loratadine | HUMAN OTC DRUG LABEL | 1 | 0363-0527 | TABLET, ORALLY DISINTEGRATING | 10 mg | ORAL | ANDA | 15 sections |
Wal itin | HUMAN OTC DRUG LABEL | 1 | 0363-0699 | TABLET | 10 mg | ORAL | ANDA | 15 sections |
Loratadine and Pseudoephedrine | HUMAN OTC DRUG LABEL | 2 | 0363-0725 | TABLET, FILM COATED, EXTENDED RELEASE | 10 mg | ORAL | ANDA | 16 sections |
Loratadine | HUMAN OTC DRUG LABEL | 1 | 0363-0752 | TABLET, CHEWABLE | 5 mg | ORAL | ANDA | 16 sections |
Wal-itin | HUMAN OTC DRUG LABEL | 1 | 0363-0754 | TABLET, CHEWABLE | 5 mg | ORAL | ANDA | 16 sections |
Indoor Outdoor Allergy Relief | HUMAN OTC DRUG LABEL | 1 | 0363-0858 | TABLET | 10 mg | ORAL | ANDA | 14 sections |
12 hour allergy and congestion | HUMAN OTC DRUG LABEL | 2 | 0363-1133 | TABLET, FILM COATED, EXTENDED RELEASE | 5 mg | ORAL | ANDA | 14 sections |
allergy relief | HUMAN OTC DRUG LABEL | 1 | 0363-1612 | TABLET | 10 mg | ORAL | ANDA | 15 sections |
allergy relief | HUMAN OTC DRUG LABEL | 1 | 0363-1612 | TABLET | 10 mg | ORAL | ANDA | 15 sections |
WAL-ITIN | HUMAN OTC DRUG LABEL | 1 | 0363-1686 | CAPSULE, LIQUID FILLED | 10 mg | ORAL | ANDA | 16 sections |
WAL-ITIN | HUMAN OTC DRUG LABEL | 1 | 0363-1686 | CAPSULE, LIQUID FILLED | 10 mg | ORAL | ANDA | 16 sections |
Wal-itin Allergy Relief | HUMAN OTC DRUG LABEL | 1 | 0363-2085 | SOLUTION | 5 mg | ORAL | ANDA | 15 sections |