loratadine ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
histamine-H1 receptor antagonists, tricyclic compounds 1605 79794-75-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • loratadine
  • claritin
  • loracert
  • loradex
  • loratidine
  • loratyne
A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.
  • Molecular weight: 382.89
  • Formula: C22H23ClN2O2
  • CLOGP: 5.05
  • LIPINSKI: 1
  • HAC: 4
  • HDO: 0
  • TPSA: 42.43
  • ALOGS: -4.46
  • ROTB: 2

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 5 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.44 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 40 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
April 12, 1993 FDA BAYER HEALTHCARE LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Extra dose administered 289.99 9.83 149 85034 5324 56201560
Rheumatoid arthritis 226.11 9.83 151 85032 382453 55824431
Contraindicated product administered 212.06 9.83 19 85164 186267 56020617
Synovitis 190.39 9.83 14 85169 161291 56045593
Drug ineffective 178.75 9.83 752 84431 918237 55288647
Glossodynia 174.98 9.83 15 85168 152443 56054441
Accidental exposure to product by child 170.84 9.83 65 85118 1108 56205776
Hand deformity 166.67 9.83 9 85174 134483 56072401
Systemic lupus erythematosus 159.96 9.83 38 85145 180040 56026844
Gastrooesophageal reflux disease 152.79 9.83 368 84815 82889 56123995
Drug intolerance 150.32 9.83 109 85074 264709 55942175
Pneumonia aspiration 146.07 9.83 211 84972 32200 56174684
Treatment failure 145.46 9.83 39 85144 170353 56036531
Wound 140.89 9.83 21 85162 138783 56068101
Arthropathy 130.80 9.83 70 85113 200205 56006679
Pericarditis 124.19 9.83 11 85172 108912 56097972
Failure of child resistant product closure 118.81 9.83 23 85160 9 56206875
Joint swelling 116.66 9.83 161 85022 289639 55917245
Urticaria 109.91 9.83 472 84711 144204 56062680
Therapeutic product effect decreased 99.71 9.83 67 85116 169385 56037499
Somnolence 96.19 9.83 495 84688 162918 56043966
Maternal exposure during pregnancy 93.91 9.83 89 85094 189464 56017420
General physical health deterioration 78.31 9.83 85 85098 169925 56036959
Off label use 77.82 9.83 508 84675 555672 55651212
Hepatic enzyme increased 77.49 9.83 87 85096 171297 56035587
Asthma 77.37 9.83 357 84826 112413 56094471
Alopecia 76.38 9.83 211 84972 293247 55913637
Swelling face 72.67 9.83 218 84965 55851 56151033
Helicobacter infection 67.96 9.83 14 85169 73254 56133630
Muscle injury 66.65 9.83 3 85180 52497 56154387
Toxicity to various agents 66.55 9.83 151 85032 224413 55982471
Dizziness 65.88 9.83 863 84320 375277 55831607
Pruritus 62.96 9.83 744 84439 315879 55891005
Coma 62.82 9.83 216 84967 59439 56147445
Swelling 61.91 9.83 173 85010 239598 55967286
Anxiety 60.96 9.83 500 84683 192672 56014212
Drug abuse 58.56 9.83 15 85168 67595 56139289
Cholecystitis chronic 58.51 9.83 73 85110 9675 56197209
Feeling abnormal 57.79 9.83 373 84810 133229 56073655
Folliculitis 56.50 9.83 8 85175 54971 56151913
Infective pulmonary exacerbation of cystic fibrosis 55.34 9.83 65 85118 8092 56198792
Angioedema 54.49 9.83 162 85021 41291 56165593
Lower respiratory tract infection 54.40 9.83 56 85127 114738 56092146
Muscle spasms 54.29 9.83 375 84808 136996 56069888
Insomnia 53.40 9.83 483 84700 191377 56015507
Butterfly rash 52.20 9.83 31 85152 1475 56205409
Cough 52.14 9.83 612 84571 259349 55947535
Sleep disorder due to general medical condition, insomnia type 50.42 9.83 4 85179 43334 56163550
Chest discomfort 49.70 9.83 287 84896 98570 56108314
Lip swelling 49.08 9.83 117 85066 26155 56180729
Dermatitis atopic 47.98 9.83 61 85122 8238 56198646
Headache 47.46 9.83 1143 84040 557901 55648983
Discomfort 47.31 9.83 89 85094 141672 56065212
Palpitations 47.29 9.83 285 84898 99387 56107497
Musculoskeletal stiffness 46.11 9.83 105 85078 155902 56050982
Product dose omission issue 45.55 9.83 492 84691 204261 56002623
C-reactive protein increased 45.07 9.83 32 85151 78652 56128232
Acute kidney injury 44.54 9.83 200 84983 240563 55966321
Dyspnoea 43.68 9.83 1189 83994 591388 55615496
Emotional distress 41.69 9.83 119 85064 29644 56177240
Bronchitis 39.96 9.83 299 84884 112012 56094872
Mobility decreased 38.75 9.83 56 85127 98935 56107949
Sinusitis 38.63 9.83 463 84720 197118 56009766
Seasonal allergy 38.45 9.83 82 85101 17026 56189858
Impaired healing 38.23 9.83 45 85138 86796 56120088
Depression 36.50 9.83 425 84758 179692 56027192
Tinnitus 36.29 9.83 114 85069 29928 56176956
Periorbital oedema 35.86 9.83 42 85141 5212 56201672
Gallbladder disorder 35.46 9.83 80 85103 17254 56189630
C-reactive protein abnormal 34.20 9.83 7 85176 36802 56170082
Abdominal discomfort 33.88 9.83 263 84920 277011 55929873
Knee arthroplasty 32.68 9.83 13 85170 44246 56162638
Blister 32.39 9.83 73 85110 108814 56098070
Rhinitis allergic 32.24 9.83 51 85132 8423 56198461
Pancytopenia 31.11 9.83 54 85129 88661 56118223
Anaphylactic reaction 30.77 9.83 173 85010 58822 56148062
Nasal congestion 30.53 9.83 167 85016 56203 56150681
Therapeutic product effect incomplete 30.01 9.83 73 85110 105958 56100926
Ill-defined disorder 29.65 9.83 36 85147 68507 56138377
Infection 29.33 9.83 180 85003 200026 56006858
Diarrhoea 28.58 9.83 1209 83974 637298 55569586
Sinus disorder 28.17 9.83 82 85101 20652 56186232
Throat irritation 27.41 9.83 110 85073 32573 56174311
Allergy test positive 27.17 9.83 13 85170 397 56206487
Chest pain 26.93 9.83 420 84763 189377 56017507
Liver injury 26.74 9.83 15 85168 41833 56165051
Product use issue 26.35 9.83 169 85014 185872 56021012
Head discomfort 26.32 9.83 57 85126 11957 56194927
Upper respiratory tract infection 26.03 9.83 191 84992 71097 56135787
Mast cell activation syndrome 25.98 9.83 15 85168 677 56206207
Photosensitivity reaction 25.89 9.83 61 85122 13532 56193352
Multiple organ dysfunction syndrome 25.84 9.83 25 85158 52745 56154139
Gastrointestinal disorder 24.36 9.83 88 85095 112614 56094270
Tinea pedis 23.57 9.83 18 85165 1302 56205582
Multiple allergies 23.23 9.83 50 85133 10446 56196438
Acquired haemophilia 22.91 9.83 16 85167 1008 56205876
Rhabdomyolysis 22.67 9.83 17 85166 40641 56166243
Feeling hot 22.09 9.83 123 85060 41664 56165220
Infusion related reaction 21.99 9.83 206 84977 208725 55998159
Biliary dyskinesia 21.82 9.83 23 85160 2540 56204344
Essential hypertension 21.79 9.83 31 85152 4662 56202222
Dry mouth 21.74 9.83 169 85014 64036 56142848
Throat tightness 21.74 9.83 79 85104 22328 56184556
Hypersomnia 21.60 9.83 64 85119 16277 56190607
Oropharyngeal pain 21.30 9.83 207 84976 83581 56123303
Cystitis noninfective 21.28 9.83 15 85168 959 56205925
Cystoid macular oedema 21.12 9.83 18 85165 1523 56205361
Deep vein thrombosis 20.97 9.83 193 84990 76784 56130100
Paraesthesia 20.92 9.83 295 84888 130219 56076665
Hepatocellular injury 20.91 9.83 7 85176 26507 56180377
Nervousness 20.72 9.83 93 85090 28922 56177962
Vision blurred 20.64 9.83 204 84979 82739 56124145
Malignant neoplasm progression 20.55 9.83 51 85132 73536 56133348
Hip arthroplasty 20.46 9.83 17 85166 38606 56168278
Expired product administered 20.33 9.83 33 85150 5569 56201315
Eye pruritus 20.09 9.83 57 85126 14149 56192735
Incorrect dose administered 19.88 9.83 142 85041 52405 56154479
Abdominal distension 19.84 9.83 192 84991 77434 56129450
Dry skin 19.41 9.83 130 85053 46979 56159905
Intentional product use issue 18.93 9.83 82 85101 99651 56107233
Urinary tract infection 18.88 9.83 487 84696 240026 55966858
Eye swelling 18.77 9.83 73 85110 21303 56185581
Bone pain 18.63 9.83 135 85048 50050 56156834
Suicidal ideation 18.46 9.83 150 85033 57592 56149292
Cholelithiasis 18.17 9.83 112 85071 39352 56167532
Migraine 18.09 9.83 206 84977 86591 56120293
Lupus hepatitis 17.94 9.83 5 85178 29 56206855
Nausea 17.70 9.83 1363 83820 762815 55444069
Thrombocytopenia 17.66 9.83 127 85056 136097 56070787
Status asthmaticus 17.58 9.83 13 85170 896 56205988
Gallbladder injury 17.44 9.83 15 85168 1285 56205599
Arthralgia 17.43 9.83 603 84580 501066 55705818
Condition aggravated 17.24 9.83 394 84789 344504 55862380
Swollen tongue 17.20 9.83 91 85092 30233 56176651
Premature baby 17.13 9.83 4 85179 19201 56187683
Neuropathy peripheral 17.07 9.83 234 84949 102659 56104225
Abnormal dreams 16.98 9.83 42 85141 9607 56197277
Renal impairment 16.80 9.83 64 85119 80649 56126235
Upper-airway cough syndrome 16.52 9.83 41 85142 9397 56197487
Medication error 16.51 9.83 24 85159 42311 56164573
Cardiac failure 16.50 9.83 66 85117 82027 56124857
Allergic cystitis 16.49 9.83 3 85180 0 56206884
Sinus headache 16.38 9.83 28 85155 4930 56201954
Septic shock 16.34 9.83 43 85140 60792 56146092
Temperature intolerance 16.32 9.83 37 85146 8003 56198881
Red blood cell sedimentation rate increased 16.09 9.83 19 85164 36604 56170280
Hyperkalaemia 16.03 9.83 33 85150 50832 56156052
Erythema 16.03 9.83 328 84855 155611 56051273
Pulmonary fibrosis 15.89 9.83 13 85170 29745 56177139
Psoriatic arthropathy 15.85 9.83 58 85125 73950 56132934
Sopor 15.68 9.83 6 85177 20916 56185968
Basophil count decreased 15.57 9.83 6 85177 106 56206778
Pulmonary embolism 15.54 9.83 238 84945 106886 56099998
Illness 15.30 9.83 97 85086 34414 56172470
Drug resistance 15.22 9.83 6 85177 20536 56186348
Hepatotoxicity 14.97 9.83 15 85168 31138 56175746
Pre-existing condition improved 14.97 9.83 34 85149 7364 56199520
Nasal disorder 14.96 9.83 19 85164 2563 56204321
Back pain 14.93 9.83 467 84716 236703 55970181
Posterior reversible encephalopathy syndrome 14.90 9.83 3 85180 15957 56190927
Inflammation 14.87 9.83 54 85129 69017 56137867
White blood cell count decreased 14.64 9.83 270 84913 125720 56081164
Reversible cerebral vasoconstriction syndrome 14.58 9.83 18 85165 2359 56204525
Dysgeusia 14.58 9.83 109 85074 40806 56166078
Hyponatraemia 14.34 9.83 93 85090 102046 56104838
Dyspepsia 14.32 9.83 191 84992 83280 56123604
Emotional disorder 14.25 9.83 46 85137 12249 56194635
Loss of personal independence in daily activities 14.19 9.83 69 85114 81300 56125584
Chills 14.14 9.83 226 84957 102378 56104506
Crying 14.04 9.83 67 85116 21373 56185511
Neurological examination abnormal 13.99 9.83 7 85176 236 56206648
Osteonecrosis of jaw 13.92 9.83 18 85165 33340 56173544
Hot flush 13.67 9.83 119 85064 46607 56160277
Completed suicide 13.62 9.83 133 85050 133700 56073184
Depressed level of consciousness 13.60 9.83 42 85141 56391 56150493
Chronic spontaneous urticaria 13.49 9.83 12 85171 1075 56205809
Drug interaction 13.37 9.83 230 84953 209525 55997359
Injury 13.36 9.83 144 85039 59707 56147177
Bronchospasm 13.35 9.83 53 85130 15616 56191268
Reflux gastritis 13.28 9.83 12 85171 1098 56205786
Agranulocytosis 13.25 9.83 9 85174 22650 56184234
Victim of chemical submission 13.04 9.83 8 85175 404 56206480
Impaired quality of life 12.97 9.83 35 85148 8439 56198445
Red blood cell sedimentation rate abnormal 12.96 9.83 6 85177 18667 56188217
Anger 12.93 9.83 43 85140 11629 56195255
Xanthogranuloma 12.88 9.83 3 85180 7 56206877
Cataract subcapsular 12.87 9.83 9 85174 568 56206316
Snoring 12.87 9.83 21 85162 3560 56203324
Initial insomnia 12.83 9.83 27 85156 5552 56201332
Rash 12.83 9.83 888 84295 492159 55714725
Oesophageal adenocarcinoma recurrent 12.82 9.83 4 85179 36 56206848
Palmar erythema 12.80 9.83 14 85169 1613 56205271
Burning sensation 12.71 9.83 121 85062 48575 56158309
Mitral valve prolapse 12.41 9.83 16 85167 2190 56204694
Autoimmune hepatitis 12.41 9.83 33 85150 7888 56198996
Panic disorder 12.38 9.83 17 85166 2474 56204410
Cytomegalovirus infection 12.21 9.83 7 85176 19289 56187595
Cluster headache 12.20 9.83 9 85174 618 56206266
Fracture 12.19 9.83 6 85177 18012 56188872
Wheezing 12.18 9.83 170 85013 74856 56132028
Overdose 12.15 9.83 102 85081 105728 56101156
Somnambulism 12.13 9.83 25 85158 5067 56201817
Infusion site erythema 12.11 9.83 37 85146 9569 56197315
Hepatic failure 12.09 9.83 20 85163 33466 56173418
Heart rate increased 12.07 9.83 185 84998 83088 56123796
Acute hepatic failure 12.02 9.83 5 85178 16573 56190311
Sleep apnoea syndrome 12.02 9.83 74 85109 25987 56180897
Lactic acidosis 11.95 9.83 22 85161 35324 56171560
Premature delivery 11.93 9.83 14 85169 27046 56179838
Sinus congestion 11.68 9.83 51 85132 15673 56191211
Skin burning sensation 11.65 9.83 40 85143 10991 56195893
Flushing 11.45 9.83 159 85024 69941 56136943
Fatigue 11.44 9.83 1361 83822 787191 55419693
Laryngeal oedema 11.41 9.83 25 85158 5285 56201599
Acute sinusitis 11.41 9.83 20 85163 3593 56203291
Biliary sepsis 11.36 9.83 10 85173 884 56206000
Joint range of motion decreased 11.31 9.83 13 85170 25352 56181532
Presbyoesophagus 11.30 9.83 3 85180 14 56206870
Blood pressure fluctuation 11.24 9.83 28 85155 40332 56166552
Circulatory collapse 11.21 9.83 9 85174 20794 56186090
Full blood count decreased 11.21 9.83 67 85116 23282 56183602
Disturbance in attention 11.21 9.83 86 85097 32454 56174430
Live birth 11.19 9.83 8 85175 19597 56187287
Bezoar 11.16 9.83 12 85171 1356 56205528
Cerebral disorder 11.12 9.83 21 85162 3995 56202889
Ear congestion 11.04 9.83 15 85168 2160 56204724
Atopy 11.03 9.83 6 85177 241 56206643
Constipation 11.00 9.83 391 84792 201552 56005332
Product quality issue 11.00 9.83 84 85099 31652 56175232
Pneumonia 10.90 9.83 735 84448 406363 55800521
Irritable bowel syndrome 10.84 9.83 60 85123 68398 56138486
Burns first degree 10.82 9.83 3 85180 17 56206867
Death 10.79 9.83 415 84768 341011 55865873
Broad ligament tear 10.68 9.83 3 85180 18 56206866
Hypoaesthesia 10.65 9.83 285 84898 141206 56065678
Myxoedema coma 10.65 9.83 7 85176 399 56206485
Ear discomfort 10.55 9.83 29 85154 7066 56199818
Torsade de pointes 10.53 9.83 42 85141 12398 56194486
Frustration tolerance decreased 10.50 9.83 27 85156 6326 56200558
Post-traumatic stress disorder 10.48 9.83 22 85161 4516 56202368
Cyclic vomiting syndrome 10.47 9.83 4 85179 69 56206815
Patellofemoral pain syndrome 10.46 9.83 8 85175 580 56206304
Infusion site swelling 10.45 9.83 31 85152 7890 56198994
Multiple lentigines syndrome 10.44 9.83 5 85178 153 56206731
Ear swelling 10.36 9.83 11 85172 1225 56205659
Status epilepticus 10.30 9.83 5 85178 15136 56191748
Cerumen impaction 10.20 9.83 10 85173 1014 56205870
Myelosuppression 10.12 9.83 7 85176 17448 56189436
Incorrect dosage administered 10.09 9.83 13 85170 1778 56205106
Paraesthesia oral 10.08 9.83 46 85137 14403 56192481
Hyperlipidaemia 10.04 9.83 54 85129 18055 56188829
Drug level increased 9.93 9.83 10 85173 20715 56186169
Defaecation urgency 9.85 9.83 18 85165 3341 56203543

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Accidental exposure to product by child 294.52 10.66 99 39946 1403 31655896
Extra dose administered 219.17 10.66 100 39945 3300 31653999
Failure of child resistant product closure 77.42 10.66 16 40029 21 31657278
Drug abuse 74.58 10.66 11 40034 87747 31569552
Urticaria 69.36 10.66 194 39851 57323 31599976
General physical health deterioration 60.54 10.66 34 40011 113401 31543898
Rash 55.79 10.66 440 39605 201046 31456253
Pruritus 53.09 10.66 304 39741 124863 31532436
Infective pulmonary exacerbation of cystic fibrosis 50.48 10.66 51 39994 6433 31650866
Off label use 44.70 10.66 257 39788 347017 31310282
Fatigue 43.06 10.66 627 39418 334579 31322720
Drug interaction 41.15 10.66 131 39914 208412 31448887
Sinusitis 38.67 10.66 118 39927 36578 31620721
Toxicity to various agents 37.94 10.66 111 39934 181376 31475923
Completed suicide 35.41 10.66 38 40007 91476 31565823
Asthma 33.36 10.66 124 39921 42487 31614812
Drug ineffective 31.91 10.66 333 39712 395240 31262059
Acute kidney injury 30.79 10.66 217 39828 279497 31377802
Rheumatoid arthritis 29.04 10.66 12 40033 47797 31609502
Cough 28.67 10.66 278 39767 134536 31522763
Throat irritation 28.50 10.66 46 39999 9268 31648031
Sinus disorder 27.85 10.66 37 40008 6258 31651041
Swelling face 27.60 10.66 74 39971 21316 31635983
Treatment failure 25.16 10.66 10 40035 40782 31616517
Chronic spontaneous urticaria 24.43 10.66 9 40036 169 31657130
Glossodynia 23.18 10.66 25 40020 3400 31653899
Pharyngeal dystonia 23.03 10.66 7 40038 70 31657229
Lacrimation increased 22.95 10.66 37 40008 7445 31649854
Infusion related reaction 22.52 10.66 120 39925 47935 31609364
Eye pruritus 21.32 10.66 29 40016 5016 31652283
Spasmodic dysphonia 20.93 10.66 8 40037 167 31657132
Gastrointestinal mucosal necrosis 20.76 10.66 8 40037 171 31657128
Seasonal allergy 20.47 10.66 30 40015 5558 31651741
Bronchitis 20.46 10.66 100 39945 38617 31618682
Oral pruritus 20.42 10.66 9 40036 273 31657026
Expired product administered 20.12 10.66 22 40023 3039 31654260
Drug resistance 19.77 10.66 3 40042 23450 31633849
CADASIL 19.14 10.66 6 40039 67 31657232
Magnetic resonance imaging spinal abnormal 18.83 10.66 6 40039 71 31657228
Renal impairment 18.60 10.66 52 39993 86297 31571002
Conduction disorder 18.58 10.66 17 40028 1897 31655402
Visual evoked potentials abnormal 18.46 10.66 6 40039 76 31657223
Dizziness 17.93 10.66 352 39693 198795 31458504
Interstitial lung disease 17.26 10.66 32 40013 61371 31595928
Muscle spasms 17.10 10.66 146 39899 68172 31589127
Lip swelling 17.09 10.66 46 39999 13277 31644022
Central nervous system inflammation 16.89 10.66 6 40039 101 31657198
Hyperkalaemia 16.83 10.66 35 40010 64316 31592983
Blood pH decreased 16.73 10.66 17 40028 2158 31655141
Nasal congestion 16.52 10.66 60 39985 20321 31636978
PO2 increased 16.48 10.66 10 40035 595 31656704
Chills 16.28 10.66 154 39891 73996 31583303
Feeling abnormal 15.98 10.66 125 39920 56877 31600422
Angioedema 15.78 10.66 84 39961 33534 31623765
Tunnel vision 15.71 10.66 9 40036 481 31656818
Rhabdomyolysis 15.46 10.66 36 40009 63545 31593754
Metamorphopsia 15.34 10.66 9 40036 503 31656796
Ejaculation delayed 14.95 10.66 7 40038 245 31657054
Heart rate increased 14.94 10.66 96 39949 41014 31616285
Vision blurred 14.69 10.66 97 39948 41818 31615481
Leukopenia 14.66 10.66 32 40013 57796 31599503
Tension headache 14.61 10.66 13 40032 1398 31655901
Chest pain 14.60 10.66 218 39827 116739 31540560
Rhinitis allergic 14.55 10.66 18 40027 2836 31654463
Saccadic eye movement 14.55 10.66 6 40039 154 31657145
Suicidal ideation 14.47 10.66 87 39958 36319 31620980
Wheezing 14.30 10.66 86 39959 35900 31621399
Burning sensation 14.17 10.66 50 39995 16697 31640602
C-reactive protein increased 13.99 10.66 25 40020 48625 31608674
Forced expiratory volume decreased 13.95 10.66 18 40027 2959 31654340
Anxiety 13.94 10.66 176 39869 90857 31566442
Sneezing 13.88 10.66 23 40022 4736 31652563
Acute respiratory distress syndrome 13.59 10.66 7 40038 24533 31632766
Insomnia 13.54 10.66 181 39864 94655 31562644
Cerebral microangiopathy 13.52 10.66 6 40039 185 31657114
Upper respiratory tract infection 13.46 10.66 73 39972 29349 31627950
Muscle tightness 13.35 10.66 22 40023 4507 31652792
Pneumonitis 13.32 10.66 75 39970 30577 31626722
Double stranded DNA antibody positive 13.17 10.66 6 40039 197 31657102
Intercepted medication error 13.05 10.66 8 40037 485 31656814
Oropharyngeal pain 13.00 10.66 76 39969 31407 31625892
Pneumonia 12.96 10.66 532 39513 334780 31322519
Gastrooesophageal reflux disease 12.86 10.66 80 39965 33791 31623508
Hyponatraemia 12.74 10.66 49 39996 73750 31583549
Foetal exposure during pregnancy 12.68 10.66 20 40025 40856 31616443
Lactic acidosis 12.63 10.66 13 40032 31924 31625375
Mucosal inflammation 12.54 10.66 15 40030 34412 31622887
Renal failure 12.41 10.66 98 39947 123232 31534067
Skin warm 12.35 10.66 14 40031 2012 31655287
Cytomegalovirus infection 12.33 10.66 8 40037 24699 31632600
Testicular cyst 12.28 10.66 4 40041 51 31657248
Sleep apnoea syndrome 11.99 10.66 51 39994 18574 31638725
Contraindicated product administered 11.94 10.66 5 40040 19767 31637532
Rhinorrhoea 11.84 10.66 59 39986 22953 31634346
Upper-airway cough syndrome 11.76 10.66 17 40028 3110 31654189
Migraine 11.71 10.66 42 40003 14138 31643161
Headache 11.63 10.66 309 39736 183343 31473956
Cardiogenic shock 11.53 10.66 7 40038 22401 31634898
Depression 11.22 10.66 169 39876 90646 31566653
Oral viral infection 11.21 10.66 3 40042 18 31657281
Crying 11.20 10.66 23 40022 5574 31651725
Convulsions local 11.07 10.66 3 40042 19 31657280
Spinal osteoarthritis 11.05 10.66 26 40019 6909 31650390
Eosinophilia 10.98 10.66 8 40037 23245 31634054
Physical examination abnormal 10.97 10.66 6 40039 293 31657006
Drug level increased 10.83 10.66 6 40039 20180 31637119
Thrombocytopenia 10.70 10.66 122 39923 142625 31514674
Rash pruritic 10.68 10.66 59 39986 23879 31633420
Blood cholesterol increased 10.68 10.66 46 39999 16847 31640452
Agitation 10.66 10.66 110 39935 54059 31603240

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Extra dose administered 531.37 9.76 240 97926 7037 70823241
Accidental exposure to product by child 457.63 9.76 165 98001 2641 70827637
Failure of child resistant product closure 192.34 9.76 39 98127 36 70830242
Urticaria 177.04 9.76 562 97604 162487 70667791
Rheumatoid arthritis 159.23 9.76 104 98062 291701 70538577
Drug ineffective 138.74 9.76 751 97415 939001 69891277
Gastrooesophageal reflux disease 138.46 9.76 354 97812 90485 70739793
Drug abuse 130.79 9.76 23 98143 147233 70683045
Off label use 127.32 9.76 563 97603 742497 70087781
Synovitis 119.65 9.76 18 98148 129210 70701068
Contraindicated product administered 117.44 9.76 22 98144 134590 70695688
General physical health deterioration 115.86 9.76 94 98072 235937 70594341
Pruritus 108.12 9.76 833 97333 344727 70485551
Infective pulmonary exacerbation of cystic fibrosis 100.48 9.76 103 98063 12055 70818223
Treatment failure 100.29 9.76 37 98129 144105 70686173
Toxicity to various agents 96.57 9.76 244 97922 381928 70448350
Drug intolerance 95.31 9.76 103 98063 225584 70604694
Swelling face 94.00 9.76 244 97922 62920 70767358
Hand deformity 87.47 9.76 9 98157 86473 70743805
Somnolence 78.99 9.76 540 97626 215066 70615212
Joint swelling 77.70 9.76 145 98021 253066 70577212
Acute kidney injury 77.26 9.76 366 97800 474258 70356020
Asthma 75.95 9.76 350 97816 120443 70709835
Dizziness 70.21 9.76 964 97202 463177 70367101
Therapeutic product effect decreased 70.08 9.76 57 98109 142961 70687317
Pneumonia aspiration 64.15 9.76 211 97955 62078 70768200
Lip swelling 64.01 9.76 144 98022 33910 70796368
Pericarditis 63.71 9.76 19 98147 84686 70745592
Systemic lupus erythematosus 58.72 9.76 34 98132 101868 70728410
C-reactive protein increased 58.04 9.76 41 98125 110476 70719802
Wound 56.81 9.76 33 98133 98699 70731579
Angioedema 56.80 9.76 212 97954 66398 70763880
Arthropathy 56.38 9.76 75 98091 149982 70680296
Butterfly rash 56.27 9.76 31 98135 1399 70828879
Glossodynia 52.54 9.76 27 98139 86460 70743818
Drug interaction 52.07 9.76 312 97854 381129 70449149
Headache 50.48 9.76 1103 97063 579302 70250976
Cholecystitis chronic 49.53 9.76 63 98103 9313 70820965
Muscle spasms 49.53 9.76 374 97792 153672 70676606
Rash 49.52 9.76 986 97180 509576 70320702
Feeling abnormal 48.88 9.76 351 97815 141968 70688310
Helicobacter infection 48.73 9.76 9 98157 55647 70774631
Cough 47.97 9.76 673 97493 324704 70505574
Throat irritation 47.09 9.76 131 98035 35173 70795105
Insomnia 45.84 9.76 482 97684 217324 70612954
Emotional distress 45.72 9.76 134 98032 37054 70793224
Anxiety 45.63 9.76 486 97680 219844 70610434
Dyspnoea 44.97 9.76 1388 96778 768672 70061606
Fatigue 44.55 9.76 1472 96694 822847 70007431
Palpitations 43.89 9.76 283 97883 110470 70719808
Chest discomfort 42.84 9.76 307 97859 124074 70706204
Chest pain 41.68 9.76 531 97635 250729 70579549
Completed suicide 41.20 9.76 168 97998 226967 70603311
Expired product administered 40.22 9.76 47 98119 6366 70823912
Nasal congestion 39.57 9.76 188 97978 65484 70764794
Renal impairment 39.38 9.76 88 98078 143849 70686429
C-reactive protein abnormal 39.04 9.76 4 98162 38575 70791703
Product dose omission issue 38.83 9.76 466 97700 217002 70613276
Sinusitis 38.25 9.76 380 97786 168815 70661463
Rhabdomyolysis 36.85 9.76 47 98119 95713 70734565
Rhinitis allergic 36.34 9.76 54 98112 9241 70821037
Bronchitis 36.19 9.76 282 97884 116961 70713317
Dermatitis atopic 36.18 9.76 53 98113 8954 70821324
Eye pruritus 35.80 9.76 69 98097 14578 70815700
Tinnitus 34.99 9.76 120 98046 36056 70794222
Pancytopenia 34.68 9.76 101 98065 151006 70679272
Drug resistance 33.81 9.76 6 98160 38184 70792094
Vision blurred 33.61 9.76 236 97930 94748 70735530
Sleep disorder due to general medical condition, insomnia type 33.01 9.76 5 98161 35727 70794551
Hyperkalaemia 32.69 9.76 61 98105 106530 70723748
Maternal exposure during pregnancy 31.97 9.76 70 98096 115275 70715003
Thrombocytopenia 30.81 9.76 199 97967 238911 70591367
Gallbladder disorder 30.10 9.76 72 98094 17640 70812638
Folliculitis 29.47 9.76 11 98155 42559 70787719
Oropharyngeal pain 28.81 9.76 230 97936 96080 70734198
Hepatocellular injury 28.57 9.76 14 98152 46077 70784201
Hepatic enzyme increased 27.91 9.76 117 98049 156873 70673405
Chronic spontaneous urticaria 27.82 9.76 18 98148 1093 70829185
Multiple organ dysfunction syndrome 27.55 9.76 69 98097 108446 70721832
Sopor 27.49 9.76 5 98161 31262 70799016
Upper respiratory tract infection 27.48 9.76 196 97970 79078 70751200
Allergy test positive 27.23 9.76 13 98153 433 70829845
Coma 26.75 9.76 218 97948 91626 70738652
Burning sensation 26.69 9.76 144 98022 52726 70777552
Head discomfort 26.66 9.76 57 98109 12966 70817312
Cytomegalovirus infection 26.33 9.76 11 98155 39747 70790531
Lower respiratory tract infection 26.26 9.76 74 98092 111839 70718439
Therapeutic product effect incomplete 26.16 9.76 82 98084 119800 70710478
Chills 25.71 9.76 310 97856 144476 70685802
Infection 25.36 9.76 179 97987 210606 70619672
Lactic acidosis 24.92 9.76 32 98134 64992 70765286
Swollen tongue 24.50 9.76 109 98057 36937 70793341
Incorrect dose administered 24.32 9.76 167 97999 66552 70763726
Mobility decreased 24.25 9.76 68 98098 102931 70727347
Status asthmaticus 24.24 9.76 16 98150 1005 70829273
Photosensitivity reaction 24.07 9.76 70 98096 19270 70811008
Sinus disorder 23.96 9.76 69 98097 18890 70811388
Migraine 23.54 9.76 176 97990 72062 70758216
Cardiac failure 23.09 9.76 111 98055 143430 70686848
Renal failure 23.02 9.76 160 98006 188910 70641368
Intentional product use issue 22.96 9.76 87 98079 120055 70710223
Depression 22.94 9.76 395 97771 198579 70631699
Interstitial lung disease 22.57 9.76 72 98094 104613 70725665
Leukopenia 22.48 9.76 74 98092 106486 70723792
Injury 22.43 9.76 161 98005 65084 70765194
Deep vein thrombosis 22.06 9.76 243 97923 110799 70719479
Seasonal allergy 22.04 9.76 54 98112 13430 70816848
Wheezing 21.99 9.76 213 97953 93957 70736321
Periorbital oedema 21.98 9.76 39 98127 7736 70822542
Musculoskeletal stiffness 21.65 9.76 118 98048 147642 70682636
Septic shock 21.64 9.76 81 98085 112177 70718101
Throat tightness 21.62 9.76 80 98086 24942 70805336
Malignant neoplasm progression 21.46 9.76 91 98075 121648 70708630
Anaphylactic reaction 21.31 9.76 177 97989 74797 70755481
Drug level increased 21.24 9.76 12 98154 36457 70793821
Acute respiratory distress syndrome 20.75 9.76 16 98150 41238 70789040
Red blood cell sedimentation rate increased 20.73 9.76 14 98152 38628 70791650
Oral pruritus 20.61 9.76 19 98147 1952 70828326
Hepatic failure 20.43 9.76 30 98136 57595 70772683
Knee arthroplasty 20.40 9.76 11 98155 34290 70795988
Discomfort 20.37 9.76 76 98090 105360 70724918
Gallbladder injury 20.22 9.76 15 98151 1137 70829141
Crying 20.22 9.76 70 98096 21129 70809149
Circulatory collapse 20.20 9.76 12 98154 35462 70794816
Feeling hot 19.66 9.76 125 98041 48545 70781733
Overdose 19.52 9.76 146 98020 169599 70660679
Product quality issue 19.52 9.76 89 98077 30472 70799806
Lacrimation increased 19.23 9.76 66 98100 19833 70810445
Dry skin 19.21 9.76 138 98028 55793 70774485
Back pain 19.12 9.76 501 97665 270651 70559627
Impaired healing 19.11 9.76 47 98119 74327 70755951
Psoriatic arthropathy 19.04 9.76 38 98128 64733 70765545
Bone marrow failure 18.91 9.76 24 98142 48986 70781292
Gastrointestinal mucosal necrosis 18.70 9.76 8 98158 205 70830073
Cystitis noninfective 18.70 9.76 15 98151 1276 70829002
Nervousness 18.68 9.76 89 98077 31031 70799247
Agranulocytosis 18.58 9.76 17 98149 40281 70789997
Urinary tract infection 17.93 9.76 461 97705 248308 70581970
Bone pain 17.81 9.76 126 98040 50696 70779582
Hypotension 17.78 9.76 425 97741 403956 70426322
Acquired haemophilia 17.69 9.76 17 98149 1840 70828438
Incorrect dosage administered 17.68 9.76 19 98147 2348 70827930
Biliary dyskinesia 17.47 9.76 19 98147 2380 70827898
Sinus headache 17.33 9.76 26 98140 4487 70825791
Hyponatraemia 17.33 9.76 140 98026 159947 70670331
Upper-airway cough syndrome 17.01 9.76 40 98126 9691 70820587
Heart rate increased 17.01 9.76 223 97943 105925 70724353
Hypersomnia 16.80 9.76 65 98101 20699 70809579
Paraesthesia 16.80 9.76 289 97877 145248 70685030
Allergic cystitis 16.75 9.76 3 98163 0 70830278
Transient ischaemic attack 16.74 9.76 115 98051 45829 70784449
Nausea 16.71 9.76 1382 96784 850706 69979572
Cerebral haemorrhage 16.36 9.76 31 98135 53833 70776445
Erythema 16.23 9.76 376 97790 199187 70631091
Myelosuppression 16.06 9.76 11 98155 30134 70800144
Eye swelling 16.01 9.76 70 98096 23544 70806734
Osteonecrosis of jaw 15.90 9.76 20 98146 40982 70789296
Status epilepticus 15.90 9.76 7 98159 24519 70805759
Transplant rejection 15.77 9.76 3 98163 18168 70812110
Emotional disorder 15.63 9.76 47 98119 13179 70817099
Hepatotoxicity 15.50 9.76 23 98143 43963 70786315
Blood pressure fluctuation 15.39 9.76 37 98129 58975 70771303
Thrombotic microangiopathy 15.38 9.76 3 98163 17845 70812433
Pulmonary fibrosis 15.21 9.76 15 98151 34295 70795983
Cystoid macular oedema 15.16 9.76 16 98150 1936 70828342
Red blood cell sedimentation rate abnormal 15.12 9.76 4 98162 19299 70810979
Eczema 15.06 9.76 89 98077 33692 70796586
Flushing 15.04 9.76 177 97989 81995 70748283
Altered state of consciousness 15.02 9.76 20 98146 40002 70790276
Pneumonia 14.87 9.76 986 97180 595246 70235032
Cardiogenic shock 14.83 9.76 17 98149 36290 70793988
Initial insomnia 14.54 9.76 29 98137 6280 70823998
Swelling 14.51 9.76 179 97987 188360 70641918
Alopecia 14.33 9.76 191 97975 198299 70631979
Condition aggravated 14.29 9.76 467 97699 427168 70403110
Posterior reversible encephalopathy syndrome 14.25 9.76 8 98158 24394 70805884
Hyperlipidaemia 14.14 9.76 68 98098 23795 70806483
Polyneuropathy 14.06 9.76 6 98160 21409 70808869
Dry mouth 13.90 9.76 154 98012 70303 70759975
Therapy non-responder 13.86 9.76 57 98109 76858 70753420
Carotid artery disease 13.63 9.76 16 98150 2177 70828101
Administration site inflammation 13.47 9.76 3 98163 6 70830272
Victim of chemical submission 13.42 9.76 8 98158 420 70829858
Syncope 13.41 9.76 312 97854 165397 70664881
Autoimmune hepatitis 13.38 9.76 39 98127 10747 70819531
Burns first degree 13.38 9.76 4 98162 34 70830244
Full blood count decreased 13.35 9.76 67 98099 23851 70806427
Panic disorder 13.20 9.76 18 98148 2846 70827432
Oesophageal adenocarcinoma recurrent 13.18 9.76 4 98162 36 70830242
Heart rate decreased 13.12 9.76 43 98123 61972 70768306
Pulmonary embolism 13.09 9.76 295 97871 155572 70674706
Illness 13.06 9.76 82 98084 31709 70798569
Face oedema 13.05 9.76 70 98096 25569 70804709
Mast cell activation syndrome 12.89 9.76 9 98157 620 70829658
Skin exfoliation 12.87 9.76 113 98053 48513 70781765
Bronchial hyperreactivity 12.86 9.76 17 98149 2609 70827669
Multiple lentigines syndrome 12.73 9.76 6 98160 194 70830084
Patellofemoral pain syndrome 12.71 9.76 8 98158 463 70829815
Palmar erythema 12.64 9.76 14 98152 1789 70828489
Visual impairment 12.61 9.76 168 97998 80082 70750196
Hypoaesthesia 12.60 9.76 290 97876 153449 70676829
Reversible cerebral vasoconstriction syndrome 12.57 9.76 17 98149 2668 70827610
Breast pain 12.56 9.76 30 98136 7341 70822937
Exposure to toxic agent 12.55 9.76 27 98139 6167 70824111
Gastrointestinal disorder 12.44 9.76 90 98076 105337 70724941
Chronic obstructive pulmonary disease 12.39 9.76 163 98003 77478 70752800
Pneumocystis jirovecii pneumonia 12.38 9.76 14 98152 30068 70800210
Suicidal ideation 12.34 9.76 149 98017 69447 70760831
Sinus congestion 12.16 9.76 52 98114 17321 70812957
Pharyngeal dystonia 12.14 9.76 4 98162 48 70830230
Rash pruritic 12.12 9.76 137 98029 62854 70767424
Haemophagocytic lymphohistiocytosis 12.09 9.76 6 98160 19606 70810672
Conduction disorder 12.02 9.76 18 98148 3100 70827178
Tinea pedis 11.99 9.76 15 98151 2181 70828097
Melaena 11.97 9.76 39 98127 56316 70773962
Neuroleptic malignant syndrome 11.96 9.76 11 98155 25996 70804282
Neurological examination abnormal 11.90 9.76 8 98158 518 70829760
Coronary artery disease 11.87 9.76 136 98030 62600 70767678
Basophil count decreased 11.86 9.76 6 98160 227 70830051
Mitral valve prolapse 11.79 9.76 14 98152 1929 70828349
Medication error 11.67 9.76 40 98126 56872 70773406
Allergy to animal 11.66 9.76 11 98155 1164 70829114
Intervertebral disc degeneration 11.64 9.76 44 98122 13856 70816422
Laryngeal pain 11.64 9.76 25 98141 5703 70824575
Hepatic cytolysis 11.64 9.76 6 98160 19186 70811092
Depressed level of consciousness 11.64 9.76 72 98094 87359 70742919
Lethargy 11.60 9.76 157 98009 75093 70755185
Non-cardiac chest pain 11.58 9.76 33 98133 8982 70821296
Ill-defined disorder 11.55 9.76 38 98128 54703 70775575
Cholelithiasis 11.51 9.76 108 98058 47232 70783046
Paraesthesia oral 11.46 9.76 47 98119 15370 70814908
Bronchospasm 11.45 9.76 62 98104 22730 70807548
Ventricular hypertrophy 11.44 9.76 27 98139 6557 70823721
Ear congestion 11.30 9.76 15 98151 2312 70827966
Mood altered 11.29 9.76 49 98117 16426 70813852
Rotator cuff syndrome 11.24 9.76 41 98125 12693 70817585
Respiratory failure 11.24 9.76 165 98001 168570 70661708
Essential hypertension 11.22 9.76 24 98142 5460 70824818
Skin burning sensation 11.13 9.76 38 98128 11388 70818890
Dyspepsia 11.05 9.76 179 97987 88898 70741380
Ear infection 10.97 9.76 72 98094 28264 70802014
Nephropathy toxic 10.92 9.76 6 98160 18508 70811770
Rhinorrhoea 10.87 9.76 140 98026 66231 70764047
Liver disorder 10.86 9.76 46 98120 61522 70768756
Anuria 10.70 9.76 7 98159 19646 70810632
Cerebrovascular accident 10.66 9.76 267 97899 143203 70687075
Blood pressure diastolic decreased 10.61 9.76 12 98154 25768 70804510
Dysgeusia 10.60 9.76 110 98056 49392 70780886
Neutropenia 10.54 9.76 273 97893 256883 70573395
Hip arthroplasty 10.54 9.76 14 98152 28026 70802252
Pain in extremity 10.52 9.76 555 97611 327527 70502751
Otitis media 10.48 9.76 24 98142 5715 70824563
Accident at home 10.46 9.76 5 98161 167 70830111
Blister 10.38 9.76 89 98077 100437 70729841
Infusion site swelling 10.32 9.76 25 98141 6173 70824105
Uterine cyst 10.31 9.76 6 98160 301 70829977
Temperature intolerance 10.31 9.76 31 98135 8692 70821586
Hypertensive crisis 10.30 9.76 7 98159 19255 70811023
Bacterial test positive 10.29 9.76 27 98139 7004 70823274
Loss of personal independence in daily activities 10.25 9.76 72 98094 84838 70745440
Intercepted medication error 10.25 9.76 9 98157 868 70829410
Delirium 10.16 9.76 61 98105 74553 70755725
Skin necrosis 10.02 9.76 5 98161 16286 70813992
Tuberculosis 10.01 9.76 4 98162 14844 70815434
Oral viral infection 10.00 9.76 4 98162 86 70830192
Rhinovirus infection 10.00 9.76 26 98140 6707 70823571
Death 9.98 9.76 591 97575 509470 70320808
Sinus operation 9.94 9.76 13 98153 1974 70828304
Cellulitis 9.85 9.76 192 97974 98736 70731542
Blood creatinine increased 9.82 9.76 139 98027 142862 70687416
Nasal discomfort 9.81 9.76 21 98145 4780 70825498
Aphthous ulcer 9.79 9.76 4 98162 14652 70815626
Testicular cyst 9.79 9.76 3 98163 28 70830250
Cataract subcapsular 9.78 9.76 9 98157 922 70829356

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R06AX13 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Other antihistamines for systemic use
CHEBI has role CHEBI:37955 H1 receptor antagonists
CHEBI has role CHEBI:48873 acetylcholine receptor antagonist
CHEBI has role CHEBI:50857 anti-allergic drugs
CHEBI has role CHEBI:176497 geroprotectors
MeSH PA D018926 Anti-Allergic Agents
MeSH PA D000982 Antipruritics
MeSH PA D003879 Dermatologic Agents
MeSH PA D018494 Histamine Agents
MeSH PA D006633 Histamine Antagonists
MeSH PA D006634 Histamine H1 Antagonists
MeSH PA D039563 Histamine H1 Antagonists, Non-Sedating
MeSH PA D018377 Neurotransmitter Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Vasomotor rhinitis indication 8229003 DOID:4730
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Sneezing indication 76067001
Common cold indication 82272006 DOID:10459
Chronic idiopathic urticaria indication 302162004
Seasonal allergic rhinitis indication 367498001
Allergic conjunctivitis indication 473460002 DOID:11204
Bone pain after neupogen off-label use 12584003
Urticaria off-label use 126485001
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Hepatic failure contraindication 59927004
Diabetes mellitus contraindication 73211009 DOID:9351
Kidney disease contraindication 90708001 DOID:557
Impaired renal function disorder contraindication 197663003
Disease of liver contraindication 235856003 DOID:409
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Hypertensive urgency contraindication 443482000




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.43 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Histamine H1 receptor GPCR ANTAGONIST Ki 6.97 WOMBAT-PK CHEMBL
Multidrug resistance protein 1 Transporter Ki 4.94 WOMBAT-PK
5-hydroxytryptamine receptor 2B GPCR Ki 6.81 DRUG MATRIX
Nuclear receptor subfamily 1 group I member 2 Nuclear hormone receptor EC50 5.52 CHEMBL
Cytochrome P450 2C19 Enzyme IC50 7.80 DRUG MATRIX
Potassium channel subfamily K member 9 Ion channel IC50 4.20 CHEMBL
Bile acid receptor Nuclear hormone receptor IC50 5.51 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 6.77 WOMBAT-PK
Sodium-dependent neutral amino acid transporter B(0)AT2 Transporter IC50 5.40 CHEMBL
Histamine H1 receptor GPCR Kd 7.14 CHEMBL
Histamine H1 receptor GPCR Ki 6.46 CHEMBL

External reference:

IDSource
4020716 VUID
N0000148306 NUI
D00364 KEGG_DRUG
4020716 VANDF
C0065180 UMLSCUI
CHEBI:6538 CHEBI
CHEMBL998 ChEMBL_ID
DB00455 DRUGBANK_ID
D017336 MESH_DESCRIPTOR_UI
3957 PUBCHEM_CID
7216 IUPHAR_LIGAND_ID
5864 INN_ID
7AJO3BO7QN UNII
203576 RXNORM
191 MMSL
45829 MMSL
4994 MMSL
d03050 MMSL
003909 NDDF
015760 NDDF
108652002 SNOMEDCT_US
386884002 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
allergy relief HUMAN OTC DRUG LABEL 1 0067-6066 TABLET 10 mg ORAL NDA 15 sections
allergy relief HUMAN OTC DRUG LABEL 1 0067-6122 TABLET 10 mg ORAL NDA 15 sections
good sense allergy relief HUMAN OTC DRUG LABEL 1 0113-0612 TABLET 10 mg ORAL ANDA 15 sections
Good Sense childrens allergy relief HUMAN OTC DRUG LABEL 1 0113-0671 SOLUTION 5 mg ORAL ANDA 14 sections
good sense childrens allergy relief HUMAN OTC DRUG LABEL 1 0113-1019 TABLET, CHEWABLE 5 mg ORAL ANDA 15 sections
good sense allergy relief HUMAN OTC DRUG LABEL 1 0113-1191 TABLET, ORALLY DISINTEGRATING 10 mg ORAL ANDA 15 sections
good sense allergy relief HUMAN OTC DRUG LABEL 1 0113-1612 TABLET 10 mg ORAL ANDA 15 sections
good sense childrens allergy relief HUMAN OTC DRUG LABEL 1 0113-1719 SOLUTION 5 mg ORAL ANDA 14 sections
Allergy and Congestion Relief HUMAN OTC DRUG LABEL 2 0113-2007 TABLET, FILM COATED, EXTENDED RELEASE 5 mg ORAL ANDA 14 sections
basic care childrens allergy relief HUMAN OTC DRUG LABEL 1 0113-7500 TABLET, CHEWABLE 5 mg ORAL ANDA 15 sections
basic care childrens allergy relief HUMAN OTC DRUG LABEL 1 0113-7500 TABLET, CHEWABLE 5 mg ORAL ANDA 15 sections
Basic Care allergy relief HUMAN OTC DRUG LABEL 1 0113-7612 TABLET 10 mg ORAL ANDA 15 sections
Basic Care Childrens Allergy Relief HUMAN OTC DRUG LABEL 1 0113-7671 SOLUTION 5 mg ORAL ANDA 14 sections
perrigo allergy d HUMAN OTC DRUG LABEL 2 0113-7777 TABLET, FILM COATED, EXTENDED RELEASE 5 mg ORAL ANDA 15 sections
good sense allergy relief HUMAN OTC DRUG LABEL 1 0113-9755 TABLET, ORALLY DISINTEGRATING 10 mg ORAL ANDA 15 sections
Childrens Loratadine HUMAN OTC DRUG LABEL 1 0121-0849 SOLUTION 5 mg ORAL ANDA 16 sections
Childrens Loratadine HUMAN OTC DRUG LABEL 1 0121-0849 SOLUTION 5 mg ORAL ANDA 16 sections
Loratadine HUMAN OTC DRUG LABEL 1 0363-0522 TABLET 10 mg ORAL ANDA 15 sections
Loratadine HUMAN OTC DRUG LABEL 1 0363-0527 TABLET, ORALLY DISINTEGRATING 10 mg ORAL ANDA 15 sections
Wal itin HUMAN OTC DRUG LABEL 1 0363-0699 TABLET 10 mg ORAL ANDA 15 sections
Loratadine and Pseudoephedrine HUMAN OTC DRUG LABEL 2 0363-0725 TABLET, FILM COATED, EXTENDED RELEASE 10 mg ORAL ANDA 16 sections
Loratadine HUMAN OTC DRUG LABEL 1 0363-0752 TABLET, CHEWABLE 5 mg ORAL ANDA 16 sections
Wal-itin HUMAN OTC DRUG LABEL 1 0363-0754 TABLET, CHEWABLE 5 mg ORAL ANDA 16 sections
Indoor Outdoor Allergy Relief HUMAN OTC DRUG LABEL 1 0363-0858 TABLET 10 mg ORAL ANDA 14 sections
12 hour allergy and congestion HUMAN OTC DRUG LABEL 2 0363-1133 TABLET, FILM COATED, EXTENDED RELEASE 5 mg ORAL ANDA 14 sections
allergy relief HUMAN OTC DRUG LABEL 1 0363-1612 TABLET 10 mg ORAL ANDA 15 sections
allergy relief HUMAN OTC DRUG LABEL 1 0363-1612 TABLET 10 mg ORAL ANDA 15 sections
WAL-ITIN HUMAN OTC DRUG LABEL 1 0363-1686 CAPSULE, LIQUID FILLED 10 mg ORAL ANDA 16 sections
WAL-ITIN HUMAN OTC DRUG LABEL 1 0363-1686 CAPSULE, LIQUID FILLED 10 mg ORAL ANDA 16 sections
Wal-itin Allergy Relief HUMAN OTC DRUG LABEL 1 0363-2085 SOLUTION 5 mg ORAL ANDA 15 sections