loratadine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
histamine-H1 receptor antagonists, tricyclic compounds 1605 79794-75-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • loratadine
  • claritin
  • loracert
  • loradex
  • loratidine
  • loratyne
A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.
  • Molecular weight: 382.89
  • Formula: C22H23ClN2O2
  • CLOGP: 5.05
  • LIPINSKI: 1
  • HAC: 4
  • HDO: 0
  • TPSA: 42.43
  • ALOGS: -4.46
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 5 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.44 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 40 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAPK10,MAPKAPK2,PDK1,PDK4,PRKDC 16
kinase-selectivity-class ACVR2B,AXL,BRAF,GRK2,MAP2K6,MAPK12,STK33,TTK 8
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.438 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 1
rat-kpuu-brain Rat brain Kpuu 1.928 % High 1

Approvals:

DateAgencyCompanyOrphan
April 12, 1993 FDA BAYER HEALTHCARE LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hand deformity 320.79 9.75 9 110839 296353 90221246
Glossodynia 320.68 9.75 18 110830 321761 90195838
Systemic lupus erythematosus 304.82 9.75 41 110807 361855 90155744
Contraindicated product administered 287.68 9.75 29 110819 320110 90197489
Wound 281.43 9.75 24 110824 302956 90214643
Pericarditis 279.10 9.75 12 110836 270139 90247460
Synovitis 273.81 9.75 39 110809 329713 90187886
Extra dose administered 269.45 9.75 157 110691 8961 90508638
Dermatitis atopic 226.84 9.75 205 110643 23267 90494332
Helicobacter infection 207.82 9.75 19 110829 226831 90290768
Folliculitis 204.85 9.75 11 110837 204342 90313257
Muscle injury 200.44 9.75 3 110845 176651 90340948
Drug intolerance 192.55 9.75 159 110689 447432 90070167
Treatment failure 186.95 9.75 69 110779 303859 90213740
Accidental exposure to product by child 176.21 9.75 65 110783 1268 90516331
Arthropathy 174.37 9.75 117 110731 366125 90151474
General physical health deterioration 173.75 9.75 110 110738 355005 90162594
Pneumonia aspiration 158.81 9.75 222 110626 40718 90476881
Joint swelling 150.16 9.75 240 110608 503060 90014539
Lower respiratory tract infection 142.59 9.75 64 110784 250595 90267004
Hepatic enzyme increased 142.08 9.75 139 110709 360597 90157002
Liver injury 141.89 9.75 20 110828 170547 90347052
Maternal exposure during pregnancy 141.51 9.75 139 110709 359924 90157675
Somnolence 141.43 9.75 568 110280 208516 90309083
Sleep disorder due to general medical condition, insomnia type 138.82 9.75 4 110844 128690 90388909
Impaired healing 136.05 9.75 58 110790 234141 90283458
Therapeutic product effect decreased 135.70 9.75 86 110762 277485 90240114
Cough 135.12 9.75 842 110006 368120 90149479
Human rhinovirus test positive 134.16 9.75 48 110800 855 90516744
Mobility decreased 127.71 9.75 74 110774 250660 90266939
Respiratory syncytial virus test positive 126.75 9.75 48 110800 1010 90516589
C-reactive protein abnormal 124.20 9.75 8 110840 127421 90390178
Failure of child resistant product closure 123.69 9.75 23 110825 9 90517590
Alopecia 120.41 9.75 267 110581 494804 90022795
Swelling 112.04 9.75 214 110634 418844 90098755
Anaphylactic reaction 104.22 9.75 288 110560 87236 90430363
Ill-defined disorder 100.82 9.75 50 110798 184841 90332758
Lip dry 99.40 9.75 6 110842 100949 90416650
Product dose omission issue 98.30 9.75 652 110196 291035 90226564
Off label use 95.51 9.75 876 109972 1101376 89416223
Urticaria 94.72 9.75 681 110167 312053 90205546
Gastrooesophageal reflux disease 93.99 9.75 428 110420 165909 90351690
Blister 93.87 9.75 104 110744 254894 90262705
Facet joint syndrome 93.49 9.75 7 110841 98382 90419217
Irritable bowel syndrome 91.19 9.75 72 110776 207376 90310223
Breast cancer stage III 89.72 9.75 3 110845 84444 90433155
Swelling face 89.35 9.75 260 110588 81092 90436507
Feeling abnormal 89.11 9.75 423 110425 166812 90350787
Chest discomfort 88.05 9.75 369 110479 137996 90379603
Drug ineffective 87.55 9.75 1182 109666 1383116 89134483
Viral test positive 87.38 9.75 32 110816 611 90516988
Type 2 diabetes mellitus 85.06 9.75 74 110774 203170 90314429
Pulmonary fibrosis 83.99 9.75 15 110833 107488 90410111
C-reactive protein increased 83.51 9.75 60 110788 181329 90336270
Lip swelling 81.31 9.75 159 110689 38451 90479148
Rheumatoid arthritis 80.57 9.75 205 110643 362409 90155190
Asthma 78.97 9.75 537 110311 241623 90275976
Wound infection 78.60 9.75 17 110831 106385 90411214
Fibromyalgia 78.26 9.75 82 110766 206187 90311412
Pruritus 77.76 9.75 1007 109841 540518 89977081
Angioedema 77.74 9.75 214 110634 64662 90452937
Psoriatic arthropathy 76.72 9.75 100 110748 228235 90289364
Musculoskeletal stiffness 75.27 9.75 156 110692 296376 90221223
Cholecystitis chronic 74.37 9.75 75 110773 9751 90507848
Impaired quality of life 73.15 9.75 114 110734 23030 90494569
Infusion related reaction 72.99 9.75 263 110585 416517 90101082
Pneumonia haemophilus 72.93 9.75 36 110812 1467 90516132
Joint range of motion decreased 71.97 9.75 38 110810 135605 90381994
Back pain 71.16 9.75 645 110203 316530 90201069
Dyspnoea 70.91 9.75 1489 109359 879466 89638133
Nasal congestion 70.87 9.75 244 110604 83170 90434429
Coma 70.24 9.75 222 110626 72410 90445189
Dizziness 70.15 9.75 1060 109788 588224 89929375
Palpitations 67.91 9.75 339 110509 136389 90381210
Tongue biting 66.40 9.75 38 110810 2095 90515504
Infective pulmonary exacerbation of cystic fibrosis 64.50 9.75 71 110777 10208 90507391
Stomatitis 64.37 9.75 151 110697 274547 90243052
Bronchitis 63.55 9.75 361 110487 152566 90365033
COVID-19 63.35 9.75 388 110460 168455 90349144
Seasonal allergy 62.83 9.75 106 110742 22877 90494722
Discomfort 62.54 9.75 153 110695 274182 90243417
Hypercholesterolaemia 61.81 9.75 23 110825 100869 90416730
Throat irritation 60.71 9.75 163 110685 48532 90469067
Anxiety 60.59 9.75 612 110236 309160 90208439
Drug abuse 59.13 9.75 14 110834 82333 90435266
Oropharyngeal pain 58.91 9.75 288 110560 114899 90402700
Intentional product use issue 58.56 9.75 110 110738 216782 90300817
Product use issue 58.52 9.75 207 110641 329712 90187887
Adjustment disorder with depressed mood 57.01 9.75 3 110845 56750 90460849
Prescribed overdose 56.94 9.75 24 110824 97601 90419998
Grip strength decreased 56.89 9.75 21 110827 92555 90425044
Blood cholesterol increased 56.59 9.75 105 110743 207907 90309692
Inflammation 56.18 9.75 82 110766 178510 90339089
Mouth haemorrhage 55.58 9.75 60 110788 8441 90509158
Gastrointestinal disorder 55.54 9.75 147 110701 256540 90261059
Emotional distress 55.39 9.75 132 110716 36530 90481069
Therapeutic product effect incomplete 55.34 9.75 95 110753 193801 90323798
Urinary tract infection 55.12 9.75 594 110254 305038 90212561
Vision blurred 53.73 9.75 272 110576 110021 90407578
Abdominal discomfort 52.96 9.75 354 110494 476974 90040625
Bursitis 52.61 9.75 50 110798 131604 90385995
Illness 52.43 9.75 219 110629 81750 90435849
Incorrect dose administered 52.16 9.75 213 110635 78717 90438882
Toxicity to various agents 52.12 9.75 179 110669 287667 90229932
Live birth 50.22 9.75 17 110831 79090 90438509
Peripheral venous disease 49.96 9.75 20 110828 83901 90433698
Gait inability 49.32 9.75 64 110784 146392 90371207
Headache 49.03 9.75 1391 109457 861355 89656244
Pharyngeal swelling 47.93 9.75 60 110788 9884 90507715
Prescribed underdose 47.84 9.75 16 110832 75003 90442596
Chronic spontaneous urticaria 47.67 9.75 29 110819 1791 90515808
Butterfly rash 47.66 9.75 31 110817 2154 90515445
Diarrhoea 47.37 9.75 1492 109356 937698 89579901
Upper respiratory tract infection 46.94 9.75 293 110555 128025 90389574
Nail disorder 46.66 9.75 8 110840 59059 90458540
Lung disorder 45.99 9.75 70 110778 149813 90367786
Mast cell activation syndrome 45.91 9.75 27 110821 1567 90516032
Infection 45.09 9.75 259 110589 361835 90155764
Dry skin 44.16 9.75 219 110629 87854 90429745
Temperature intolerance 43.35 9.75 63 110785 11967 90505632
Carbuncle 43.15 9.75 25 110823 1411 90516188
Head discomfort 42.89 9.75 74 110774 16259 90501340
Hip arthroplasty 42.45 9.75 20 110828 76188 90441411
Gallbladder disorder 42.24 9.75 82 110766 19721 90497878
Monoclonal immunoglobulin present 41.17 9.75 28 110820 2096 90515503
Lower limb fracture 40.60 9.75 27 110821 84986 90432613
Medication error 40.27 9.75 27 110821 84625 90432974
White blood cell count decreased 39.57 9.75 344 110504 166765 90350834
Onychomadesis 39.17 9.75 5 110843 45993 90471606
Throat tightness 39.10 9.75 101 110747 29383 90488216
Blepharospasm 38.69 9.75 10 110838 55435 90462164
Autoimmune disorder 38.54 9.75 23 110825 76721 90440878
Erythema 38.31 9.75 439 110409 228807 90288792
Eye swelling 38.29 9.75 100 110748 29286 90488313
Flushing 38.14 9.75 211 110637 88280 90429319
Eczema 37.60 9.75 146 110702 52724 90464875
Deep vein thrombosis 37.20 9.75 215 110633 91405 90426194
Nausea 36.59 9.75 1683 109165 1108633 89408966
Confusional state 36.31 9.75 300 110548 385905 90131694
Periorbital oedema 35.97 9.75 43 110805 6756 90510843
Delirium 35.76 9.75 45 110803 104314 90413285
Tinnitus 34.80 9.75 124 110724 42978 90474621
Bone pain 34.61 9.75 159 110689 61824 90455775
Post-traumatic stress disorder 34.20 9.75 42 110806 6786 90510813
Chills 34.06 9.75 277 110571 131704 90385895
Knee arthroplasty 33.92 9.75 31 110817 83151 90434448
Injection site pain 33.83 9.75 343 110505 173356 90344243
Post cholecystectomy syndrome 33.76 9.75 18 110830 863 90516736
Neuropathy peripheral 33.49 9.75 284 110564 136686 90380913
Rash macular 33.45 9.75 97 110751 30183 90487416
Cholelithiasis 33.35 9.75 140 110708 52366 90465233
Insomnia 33.28 9.75 583 110265 332891 90184708
Hypothalamo-pituitary disorder 32.90 9.75 25 110823 2227 90515372
Nervousness 32.83 9.75 104 110744 33952 90483647
Photosensitivity reaction 32.36 9.75 69 110779 17738 90499861
Overweight 32.17 9.75 38 110810 5896 90511703
Essential hypertension 31.88 9.75 39 110809 6276 90511323
Multiple allergies 31.43 9.75 62 110786 15084 90502515
Acute kidney injury 31.43 9.75 246 110602 320141 90197458
Tongue injury 31.07 9.75 15 110833 582 90517017
Fatigue 30.94 9.75 1715 109133 1152308 89365291
Hypersomnia 30.89 9.75 76 110772 21455 90496144
Swollen tongue 30.34 9.75 124 110724 45832 90471767
Oedema 30.19 9.75 134 110714 200161 90317438
Eye pruritus 30.17 9.75 91 110757 28936 90488663
Depression 30.15 9.75 526 110322 300075 90217524
Lupus-like syndrome 30.14 9.75 11 110837 48835 90468764
Night sweats 29.96 9.75 71 110777 128695 90388904
Joint dislocation 29.32 9.75 9 110839 44573 90473026
Muscle spasms 29.05 9.75 451 110397 251432 90266167
Pulmonary embolism 28.75 9.75 265 110583 130555 90387044
Tinea pedis 28.48 9.75 20 110828 1577 90516022
Myelosuppression 28.44 9.75 15 110833 53576 90464023
Syncope 28.29 9.75 267 110581 132396 90385203
Osteoarthritis 28.28 9.75 133 110715 195597 90322002
Therapy non-responder 27.53 9.75 81 110767 136623 90380976
Stress 27.39 9.75 182 110666 81213 90436386
Pathergy reaction 27.23 9.75 8 110840 73 90517526
Suicidal ideation 27.22 9.75 169 110679 73686 90443913
Dry eye 26.90 9.75 141 110707 57790 90459809
Red blood cell sedimentation rate increased 26.88 9.75 37 110811 82558 90435041
Exposure during pregnancy 26.80 9.75 176 110672 238234 90279365
Upper-airway cough syndrome 26.76 9.75 58 110790 15077 90502522
Liver disorder 26.55 9.75 69 110779 121200 90396399
Myalgia 26.02 9.75 328 110520 174797 90342802
Contusion 26.00 9.75 190 110658 251026 90266573
Product administration interrupted 25.76 9.75 51 110797 12441 90505158
Biliary dyskinesia 25.70 9.75 23 110825 2576 90515023
Cystoid macular oedema 25.70 9.75 21 110827 2079 90515520
Acquired haemophilia 25.38 9.75 16 110832 1053 90516546
Allergy test positive 25.21 9.75 14 110834 728 90516871
Adverse event 24.80 9.75 68 110780 117350 90400249
Vitamin D deficiency 24.17 9.75 61 110787 17495 90500104
Drug tolerance decreased 24.00 9.75 5 110843 32125 90485474
Ear discomfort 23.94 9.75 44 110804 10156 90507443
Vitamin B12 increased 23.91 9.75 19 110829 1807 90515792
Obesity 23.89 9.75 59 110789 105448 90412151
Hot flush 23.76 9.75 139 110709 59349 90458250
Sinus disorder 23.58 9.75 94 110754 34353 90483246
Constipation 23.41 9.75 477 110371 279918 90237681
Pre-existing condition improved 23.37 9.75 41 110807 9128 90508471
Urticaria pressure 23.17 9.75 7 110841 71 90517528
Hepatic cirrhosis 23.03 9.75 26 110822 63227 90454372
Heart rate increased 22.97 9.75 225 110623 112677 90404922
Musculoskeletal pain 22.65 9.75 120 110728 171131 90346468
Body height decreased 22.52 9.75 47 110801 11902 90505697
Granulocyte count increased 22.34 9.75 17 110831 1517 90516082
Stab wound 22.26 9.75 7 110841 82 90517517
Eye irritation 21.89 9.75 91 110757 33887 90483712
Crying 21.76 9.75 75 110773 25570 90492029
Expired product administered 21.74 9.75 34 110814 6888 90510711
Face oedema 21.38 9.75 70 110778 23248 90494351
Fibrosis 21.20 9.75 31 110817 5921 90511678
Skin exfoliation 21.15 9.75 149 110699 67764 90449835
Dysgeusia 21.11 9.75 123 110725 52437 90465162
Joint noise 20.98 9.75 29 110819 5261 90512338
Thermal burn 20.94 9.75 33 110815 6729 90510870
Surgery 20.67 9.75 109 110739 44778 90472821
Colitis ulcerative 20.63 9.75 26 110822 60240 90457359
Electric shock 20.61 9.75 17 110831 1705 90515894
Sinus headache 20.60 9.75 32 110816 6444 90511155
Thrombocytopenia 20.58 9.75 160 110688 208565 90309034
Blood immunoglobulin A increased 20.43 9.75 15 110833 1268 90516331
Infusion site erythema 20.41 9.75 49 110799 13621 90503978
Skin disorder 20.37 9.75 94 110754 36612 90480987
Malignant neoplasm progression 20.32 9.75 65 110783 106805 90410794
Exostosis 20.27 9.75 21 110827 53113 90464486
Oropharyngeal discomfort 20.25 9.75 35 110813 7700 90509899
Burning sensation 20.22 9.75 140 110708 63312 90454287
Status asthmaticus 20.21 9.75 13 110835 886 90516713
Gallbladder injury 20.19 9.75 15 110833 1291 90516308
Rash 20.07 9.75 1177 109671 794923 89722676
Cataract subcapsular 20.06 9.75 12 110836 719 90516880
Condition aggravated 20 9.75 565 110283 594980 89922619
Hepatitis 19.86 9.75 35 110813 70704 90446895
Rhabdomyolysis 19.85 9.75 20 110828 51236 90466363
Lupus hepatitis 19.78 9.75 5 110843 24 90517575
Pancytopenia 19.64 9.75 78 110770 120185 90397414
Red blood cell count decreased 19.62 9.75 110 110738 46241 90471358
Liver function test increased 19.57 9.75 47 110801 84808 90432791
Cystitis noninfective 19.56 9.75 15 110833 1354 90516245
Full blood count decreased 19.51 9.75 80 110768 29609 90487990
Emotional disorder 19.50 9.75 51 110797 14946 90502653
Lacrimation increased 19.46 9.75 75 110773 26987 90490612
Road traffic accident 19.41 9.75 67 110781 107559 90410040
Priapism 19.39 9.75 7 110841 128 90517471
Nasal disorder 19.39 9.75 22 110826 3270 90514329
Ligament sprain 19.35 9.75 50 110798 14549 90503050
Rash pruritic 19.32 9.75 169 110679 82045 90435554
Inappropriate schedule of product administration 19.04 9.75 273 110575 149660 90367939
Rhinorrhoea 18.95 9.75 178 110670 88138 90429461
Loss of personal independence in daily activities 18.77 9.75 94 110754 136011 90381588
Abnormal dreams 18.61 9.75 42 110806 11215 90506384
Inflammatory bowel disease 18.51 9.75 27 110821 5144 90512455
Chest pain 18.50 9.75 517 110331 319128 90198471
Neuralgia 18.47 9.75 82 110766 31418 90486181
Vitamin B12 deficiency 18.47 9.75 33 110815 7453 90510146
Injection site erythema 18.45 9.75 193 110655 98309 90419290
Anger 18.19 9.75 47 110801 13673 90503926
Glomerular filtration rate increased 17.98 9.75 17 110831 2043 90515556
Maternal exposure timing unspecified 17.86 9.75 3 110845 22480 90495119
Rhinitis allergic 17.80 9.75 53 110795 16732 90500867
Therapeutic response shortened 17.77 9.75 65 110783 22814 90494785
Onychomycosis 17.67 9.75 12 110836 37364 90480235
Scratch 17.66 9.75 38 110810 9828 90507771
Rheumatoid factor increased 17.51 9.75 18 110830 2393 90515206
Skin swelling 17.41 9.75 30 110818 6584 90511015
Sleep apnoea syndrome 17.39 9.75 81 110767 31666 90485933
Cytokine release syndrome 17.31 9.75 74 110774 27899 90489700
Skin oedema 17.28 9.75 13 110835 1141 90516458
Multiple organ dysfunction syndrome 17.27 9.75 36 110812 68300 90449299
Nephrolithiasis 17.27 9.75 111 110737 48974 90468625
Snoring 17.25 9.75 26 110822 5100 90512499
Frustration tolerance decreased 17.21 9.75 33 110815 7863 90509736
Migraine without aura 17.18 9.75 11 110837 744 90516855
Allergic cystitis 17.12 9.75 3 110845 0 90517599
Reflux gastritis 17.10 9.75 14 110834 1390 90516209
Limb injury 16.98 9.75 80 110768 31428 90486171
Drug resistance 16.94 9.75 8 110840 30441 90487158
Injury 16.88 9.75 157 110691 197192 90320407
Hyperlipidaemia 16.88 9.75 64 110784 22852 90494747
Flatulence 16.74 9.75 97 110751 41270 90476329
Anxiety disorder 16.62 9.75 25 110823 4897 90512702
Dactylitis 16.52 9.75 22 110826 3851 90513748
Infusion site swelling 16.42 9.75 41 110807 11679 90505920
Acute sinusitis 16.36 9.75 23 110825 4238 90513361
Epilepsy 16.34 9.75 49 110799 82157 90435442
Increased appetite 16.32 9.75 41 110807 11724 90505875
Abdominal distension 16.27 9.75 237 110611 130364 90387235
Multiple lentigines syndrome 16.24 9.75 7 110841 208 90517391
Cluster headache 15.91 9.75 11 110837 846 90516753
Injection site rash 15.78 9.75 65 110783 24108 90493491
Sciatica 15.77 9.75 67 110781 101315 90416284
Posterior reversible encephalopathy syndrome 15.64 9.75 4 110844 22335 90495264
Exposure via skin contact 15.58 9.75 38 110810 10667 90506932
Agranulocytosis 15.55 9.75 12 110836 34990 90482609
Hepatocellular injury 15.52 9.75 8 110840 28950 90488649
Dysphonia 15.52 9.75 131 110717 62953 90454646
Hepatotoxicity 15.46 9.75 20 110828 45822 90471777
Bed bug infestation 15.42 9.75 5 110843 65 90517534
Palmar erythema 15.22 9.75 15 110833 1896 90515703
Restless legs syndrome 15.12 9.75 61 110787 22409 90495190
Throat clearing 15.12 9.75 21 110827 3826 90513773
Blood potassium decreased 15.03 9.75 105 110743 47622 90469977
Hyperkalaemia 14.97 9.75 36 110812 64928 90452671
Depressed mood 14.95 9.75 109 110739 50113 90467486
Victim of chemical submission 14.94 9.75 10 110838 729 90516870
Hyperhidrosis 14.92 9.75 242 110606 136063 90381536
Foreign body in reproductive tract 14.89 9.75 12 110836 1165 90516434
Aspartate aminotransferase 14.87 9.75 10 110838 735 90516864
Mitochondrial myopathy 14.86 9.75 7 110841 257 90517342
Dyslipidaemia 14.85 9.75 36 110812 10071 90507528
Cerumen impaction 14.81 9.75 12 110836 1174 90516425
Somnambulism 14.79 9.75 27 110821 6201 90511398
Wrist deformity 14.76 9.75 19 110829 3219 90514380
Feeling hot 14.68 9.75 153 110695 77855 90439744
Coeliac disease 14.50 9.75 20 110828 44590 90473009
Chronic obstructive pulmonary disease 14.46 9.75 146 110702 73683 90443916
Sopor 14.46 9.75 6 110842 24638 90492961
Spinal disorder 14.46 9.75 39 110809 11640 90505959
Diabetic retinal oedema 14.44 9.75 8 110840 414 90517185
Bacterial test positive 14.42 9.75 25 110823 5514 90512085
Therapeutic response unexpected 14.41 9.75 59 110789 21821 90495778
Rhinovirus infection 14.34 9.75 26 110822 5937 90511662
Taste disorder 14.26 9.75 34 110814 61512 90456087
Skin discolouration 14.25 9.75 98 110750 44217 90473382
Plasma cell myeloma 14.16 9.75 92 110756 40736 90476863
Bone density decreased 14.09 9.75 50 110798 17295 90500304
Back injury 14.08 9.75 22 110826 46600 90470999
Diverticulitis 13.99 9.75 99 110749 45088 90472511
Oesophageal adenocarcinoma recurrent 13.97 9.75 4 110844 33 90517566
Cellulitis 13.96 9.75 172 110676 91165 90426434
Hepatic steatosis 13.90 9.75 85 110763 36860 90480739
Borderline personality disorder 13.85 9.75 11 110837 1045 90516554
Injection site urticaria 13.85 9.75 51 110797 17960 90499639
Multiple sclerosis 13.79 9.75 69 110779 27771 90489828
Bronchospasm 13.76 9.75 56 110792 20653 90496946
Blood glucose decreased 13.75 9.75 61 110787 23368 90494231
Arthropod bite 13.71 9.75 32 110816 8735 90508864
Spinal osteoarthritis 13.71 9.75 53 110795 19095 90498504
No adverse event 13.59 9.75 135 110713 67847 90449752
Walking aid user 13.58 9.75 14 110834 35492 90482107
Peripheral swelling 13.57 9.75 393 110455 412713 90104886
Tinea infection 13.56 9.75 12 110836 1324 90516275
Frequent bowel movements 13.56 9.75 31 110817 56904 90460695
Pulmonary thrombosis 13.48 9.75 34 110814 9748 90507851
Macular degeneration 13.40 9.75 16 110832 37954 90479645
Premature baby 13.33 9.75 7 110841 25070 90492529
Renal impairment 13.31 9.75 75 110773 105346 90412253
Drug-induced liver injury 13.25 9.75 61 110787 90257 90427342
Presbyoesophagus 13.24 9.75 3 110845 8 90517591
Normal newborn 13.21 9.75 6 110842 23356 90494243
Mitral valve prolapse 13.08 9.75 16 110832 2575 90515024
Coronary artery disease 13.06 9.75 78 110770 33545 90484054
Ulcer haemorrhage 13.06 9.75 8 110840 26313 90491286
Skin burning sensation 13.01 9.75 53 110795 19558 90498041
Vertebral lateral recess stenosis 12.95 9.75 7 110841 345 90517254
Autoimmune lung disease 12.91 9.75 5 110843 112 90517487
Renal cyst 12.90 9.75 40 110808 12910 90504689
Laryngeal oedema 12.89 9.75 27 110821 6854 90510745
Suicide attempt 12.85 9.75 145 110703 75254 90442345
Oropharyngeal swelling 12.80 9.75 10 110838 928 90516671
Nerve compression 12.80 9.75 35 110813 10531 90507068
Sleep disorder 12.77 9.75 168 110680 197862 90319737
Xanthogranuloma 12.74 9.75 3 110845 10 90517589
Pneumonia 12.73 9.75 925 109923 637134 89880465
Muscular weakness 12.73 9.75 177 110671 206489 90311110
Hypoaesthesia oral 12.69 9.75 45 110803 15555 90502044
Osteoarthropathy 12.66 9.75 7 110841 361 90517238
Cerebral disorder 12.66 9.75 24 110824 5670 90511929
Muscle strain 12.65 9.75 33 110815 9654 90507945
Nephropathy 12.62 9.75 32 110816 9203 90508396
Sensitive skin 12.61 9.75 18 110830 3363 90514236
Laryngitis 12.60 9.75 27 110821 50726 90466873
Tremor 12.58 9.75 260 110588 152913 90364686
Ventricular hypertrophy 12.57 9.75 18 110830 3373 90514226
Thrombosis 12.55 9.75 141 110707 73110 90444489
Injection site swelling 12.53 9.75 120 110728 59719 90457880
Torsade de pointes 12.53 9.75 44 110804 15138 90502461
Ligamentum flavum hypertrophy 12.50 9.75 7 110841 370 90517229
Initial insomnia 12.45 9.75 32 110816 9278 90508321
Acute hepatic failure 12.44 9.75 6 110842 22555 90495044
Lethargy 12.43 9.75 125 110723 63014 90454585
Balance disorder 12.42 9.75 177 110671 96903 90420696
Neurological examination abnormal 12.42 9.75 7 110841 375 90517224
Homicidal ideation 12.41 9.75 13 110835 1767 90515832
Influenza like illness 12.40 9.75 152 110696 80459 90437140
Biliary sepsis 12.36 9.75 10 110838 976 90516623
Neurological examination normal 12.27 9.75 4 110844 53 90517546
Septic shock 12.26 9.75 57 110791 84103 90433496
Autoimmune hepatitis 12.25 9.75 34 110814 10317 90507282
Cardiac failure congestive 12.25 9.75 179 110669 98515 90419084
Swelling of eyelid 12.14 9.75 23 110825 5431 90512168
Panic attack 12.12 9.75 64 110784 26301 90491298
Anhedonia 12.03 9.75 36 110812 11395 90506204
Influenza 11.97 9.75 238 110610 139026 90378573
Myxoedema coma 11.92 9.75 7 110841 405 90517194
Skeletal injury 11.87 9.75 11 110837 1288 90516311
Sinusitis 11.85 9.75 523 110325 342565 90175034
Aneurysm 11.75 9.75 18 110830 3582 90514017
Skin irritation 11.73 9.75 40 110808 13563 90504036
Middle insomnia 11.70 9.75 46 110802 16705 90500894
Blood pressure increased 11.69 9.75 320 110528 196897 90320702
Nightmare 11.59 9.75 55 110793 21670 90495929
Product availability issue 11.55 9.75 27 110821 7377 90510222
Sinus congestion 11.55 9.75 65 110783 27359 90490240
Mouth swelling 11.53 9.75 23 110825 5639 90511960
Burns first degree 11.45 9.75 3 110845 17 90517582
Pharyngeal oedema 11.44 9.75 40 110808 13731 90503868
Conjunctival pigmentation 11.41 9.75 4 110844 67 90517532
Streptococcal endocarditis 11.40 9.75 5 110843 155 90517444
Depressed level of consciousness 11.38 9.75 48 110800 72736 90444863
Hypothyroidism 11.35 9.75 107 110741 53020 90464579
Serotonin syndrome 11.32 9.75 18 110830 37869 90479730
Dry throat 11.32 9.75 28 110820 7932 90509667
Broad ligament tear 11.31 9.75 3 110845 18 90517581
Infusion site pain 11.29 9.75 51 110797 19687 90497912
Atopy 11.29 9.75 6 110842 286 90517313
Cholecystitis 11.26 9.75 46 110802 16994 90500605
Cardiac failure 11.23 9.75 83 110765 109413 90408186
Reversible cerebral vasoconstriction syndrome 11.22 9.75 19 110829 4111 90513488
Vaginitis gardnerella 11.19 9.75 4 110844 71 90517528
Red blood cell sedimentation rate abnormal 11.14 9.75 8 110840 24196 90493403
Mental status changes 11.10 9.75 93 110755 44586 90473013
Oropharyngeal spasm 11.10 9.75 6 110842 296 90517303
Dyspnoea exertional 10.99 9.75 136 110712 72152 90445447
Basophil count decreased 10.99 9.75 6 110842 302 90517297
Injection site scab 10.98 9.75 8 110840 668 90516931
Ear congestion 10.94 9.75 17 110831 3425 90514174
Hepatic cytolysis 10.94 9.75 13 110835 30903 90486696
Blood pressure orthostatic 10.89 9.75 4 110844 77 90517522
Toe operation 10.89 9.75 10 110838 1158 90516441
Polyneuropathy 10.89 9.75 5 110843 19336 90498263
Epistaxis 10.81 9.75 155 110693 84970 90432629
Panic disorder 10.77 9.75 16 110832 3099 90514500
Cytomegalovirus infection 10.74 9.75 10 110838 26592 90491007
Dysphagia 10.72 9.75 195 110653 112083 90405516
Blood pressure abnormal 10.67 9.75 50 110798 19595 90498004
Nasal discomfort 10.66 9.75 22 110826 5526 90512073
Purpura 10.66 9.75 41 110807 14737 90502862
Limb mass 10.62 9.75 17 110831 3511 90514088
Coronary ostial stenosis 10.61 9.75 4 110844 83 90517516
Cold-stimulus headache 10.61 9.75 4 110844 83 90517516
Psoriasis 10.60 9.75 246 110602 147508 90370091
Infusion site reaction 10.60 9.75 5 110843 19034 90498565
Nasal dryness 10.57 9.75 22 110826 5561 90512038
Fracture 10.55 9.75 7 110841 22069 90495530
Overdose 10.46 9.75 133 110715 157576 90360023
Creatinine renal clearance decreased 10.46 9.75 5 110843 18894 90498705
Drug interaction 10.38 9.75 258 110590 276195 90241404
Acne 10.36 9.75 65 110783 28442 90489157
Mood altered 10.34 9.75 45 110803 17099 90500500
Haemoptysis 10.31 9.75 73 110775 33247 90484352
Migraine with aura 10.31 9.75 16 110832 3220 90514379
Tympanic membrane disorder 10.29 9.75 5 110843 197 90517402
Glycosylated haemoglobin increased 10.28 9.75 42 110806 15520 90502079
Urticaria thermal 10.27 9.75 7 110841 526 90517073
Cholecystitis acute 10.26 9.75 30 110818 9374 90508225
Product container issue 10.26 9.75 13 110835 2168 90515431
Congenital torticollis 10.25 9.75 3 110845 27 90517572
Proctitis 10.18 9.75 3 110845 15256 90502343
Sedation complication 10.15 9.75 4 110844 16940 90500659
Skin necrosis 10.14 9.75 4 110844 16937 90500662
Pustular psoriasis 10.13 9.75 5 110843 18551 90499048
Platelet count decreased 10.12 9.75 229 110619 136740 90380859
Paraesthesia 10.10 9.75 388 110460 249938 90267661
Atrophic vulvovaginitis 10.09 9.75 12 110836 1875 90515724
Blood magnesium decreased 10.09 9.75 42 110806 15651 90501948
Paranasal sinus discomfort 10.08 9.75 23 110825 6187 90511412
Vertigo 10.04 9.75 130 110718 69681 90447918
Ear swelling 10.04 9.75 12 110836 1885 90515714
Dehydration 10.01 9.75 310 110538 194137 90323462
Patellofemoral pain syndrome 9.97 9.75 8 110840 772 90516827
Carbon monoxide poisoning 9.95 9.75 5 110843 212 90517387
Hyperuricaemia 9.94 9.75 24 110824 6695 90510904
Sinus pain 9.93 9.75 21 110827 5368 90512231
Skin discomfort 9.92 9.75 12 110836 1909 90515690
Monocyte count increased 9.91 9.75 29 110819 9068 90508531
Tendonitis 9.91 9.75 52 110796 21320 90496279
Skin fissures 9.90 9.75 51 110797 20758 90496841
Blood alkaline phosphatase increased 9.86 9.75 96 110752 47983 90469616
Immunisation reaction 9.79 9.75 8 110840 792 90516807
Cervical spinal stenosis 9.79 9.75 14 110834 2621 90514978
Dysuria 9.78 9.75 82 110766 39319 90478280
Oral pain 9.76 9.75 71 110777 32612 90484987

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Accidental exposure to product by child 283.01 10.81 96 51327 1471 42568441
Extra dose administered 183.26 10.81 103 51320 5566 42564346
Urticaria 108.47 10.81 261 51162 73775 42496137
Dermatitis atopic 103.08 10.81 99 51324 12305 42557607
Pruritus 101.76 10.81 474 50949 188297 42381615
Rash 83.12 10.81 595 50828 276359 42293553
Drug abuse 79.56 10.81 15 51408 104756 42465156
Failure of child resistant product closure 78.59 10.81 16 51407 20 42569892
General physical health deterioration 77.52 10.81 43 51380 151203 42418709
Asthma 63.33 10.81 192 51231 62122 42507790
Off label use 58.90 10.81 491 50932 637844 41932068
Infective pulmonary exacerbation of cystic fibrosis 47.94 10.81 53 51370 7765 42562147
Acute kidney injury 47.59 10.81 255 51168 367082 42202830
Fatigue 47.54 10.81 763 50660 434878 42135034
Sinusitis 43.69 10.81 141 51282 47151 42522761
Cough 43.48 10.81 365 51058 177738 42392174
Drug ineffective 43.34 10.81 520 50903 629677 41940235
Toxicity to various agents 42.07 10.81 139 51284 228997 42340915
Drug interaction 38.16 10.81 179 51244 266820 42303092
Swelling face 32.91 10.81 90 51333 27464 42542448
Throat irritation 32.14 10.81 57 51366 12979 42556933
Dry skin 31.78 10.81 129 51294 48209 42521703
Eye pruritus 30.88 10.81 52 51371 11360 42558552
Completed suicide 30.62 10.81 43 51380 96422 42473490
Lacrimation increased 29.75 10.81 52 51371 11706 42558206
Sinus disorder 29.22 10.81 42 51381 8008 42561904
Drug resistance 27.99 10.81 4 51419 34244 42535668
Renal impairment 27.76 10.81 57 51366 110171 42459741
Rhinorrhoea 26.87 10.81 92 51331 31702 42538210
Illness 26.43 10.81 78 51345 24852 42545060
Chills 25.20 10.81 197 51226 93869 42476043
Dizziness 25.01 10.81 431 50992 248823 42321089
Myelosuppression 24.61 10.81 9 51414 40452 42529460
Pharyngeal dystonia 24.01 10.81 7 51416 63 42569849
Chronic spontaneous urticaria 23.81 10.81 10 51413 282 42569630
Muscle spasms 23.49 10.81 181 51242 85863 42484049
Expired product administered 23.44 10.81 27 51396 4136 42565776
Cardiogenic shock 23.31 10.81 7 51416 35633 42534279
Infusion related reaction 23.23 10.81 139 51284 60667 42509245
Nasal congestion 22.89 10.81 83 51340 29418 42540494
Sneezing 22.81 10.81 33 51390 6330 42563582
Laryngospasm 22.72 10.81 19 51404 1969 42567943
Agitation 22.67 10.81 144 51279 64170 42505742
Chest pain 21.44 10.81 260 51163 139270 42430642
Thrombocytopenia 21.42 10.81 138 51285 190141 42379771
Seasonal allergy 20.87 10.81 36 51387 8019 42561893
Ear infection 20.75 10.81 47 51376 12757 42557155
Gastrointestinal mucosal necrosis 20.37 10.81 8 51415 189 42569723
Injection site hypersensitivity 20.24 10.81 10 51413 414 42569498
Glossodynia 20.20 10.81 25 51398 4127 42565785
Product dose omission issue 20.09 10.81 279 51144 154086 42415826
Vasospasm 19.90 10.81 11 51412 575 42569337
Priapism 19.79 10.81 31 51392 6376 42563536
Visual evoked potentials abnormal 19.58 10.81 6 51417 65 42569847
Bronchitis 19.39 10.81 110 51313 47091 42522821
Multiple organ dysfunction syndrome 19.08 10.81 57 51366 96978 42472934
Insomnia 18.89 10.81 222 51201 118031 42451881
Conduction disorder 18.87 10.81 19 51404 2499 42567413
Treatment failure 18.81 10.81 29 51394 62595 42507317
Peripheral blood stem cell apheresis 18.50 10.81 7 51416 149 42569763
Pneumonia 18.29 10.81 651 50772 421498 42148414
Rhabdomyolysis 18.26 10.81 42 51381 77977 42491935
Erythema 18.16 10.81 206 51217 108587 42461325
Oropharyngeal pain 18.08 10.81 100 51323 42410 42527502
Lip swelling 17.76 10.81 57 51366 18996 42550916
PO2 increased 17.74 10.81 10 51413 543 42569369
C-reactive protein increased 17.63 10.81 31 51392 63529 42506383
Angioedema 17.46 10.81 99 51324 42378 42527534
Headache 17.29 10.81 394 51029 238975 42330937
CADASIL 17.27 10.81 6 51417 99 42569813
Intervertebral disc protrusion 17.24 10.81 40 51383 11032 42558880
Influenza 17.08 10.81 131 51292 62044 42507868
Ocular hyperaemia 16.97 10.81 50 51373 15913 42553999
Rhinitis allergic 16.90 10.81 22 51401 3820 42566092
Blood pH decreased 16.60 10.81 17 51406 2281 42567631
Interstitial lung disease 16.22 10.81 45 51378 78417 42491495
Anaphylactoid reaction 16.21 10.81 19 51404 2964 42566948
Drug intolerance 15.99 10.81 47 51376 80377 42489535
Vision blurred 15.80 10.81 115 51308 53584 42516328
Renal failure 15.78 10.81 105 51318 143621 42426291
Heart rate increased 15.64 10.81 114 51309 53141 42516771
Lactic acidosis 15.56 10.81 19 51404 45242 42524670
Altered state of consciousness 15.43 10.81 8 51415 29251 42540661
Oral pruritus 15.38 10.81 9 51414 525 42569387
Magnetic resonance imaging spinal abnormal 15.35 10.81 6 51417 140 42569772
Hyperkalaemia 15.29 10.81 48 51375 80410 42489502
Suicidal ideation 15.25 10.81 105 51318 48056 42521856
Therapy partial responder 14.90 10.81 3 51420 20018 42549894
Hypersensitivity 14.89 10.81 143 51280 72227 42497685
Upper respiratory tract infection 14.60 10.81 94 51329 42079 42527833
Saccadic eye movement 14.57 10.81 6 51417 161 42569751
Lymphopenia 14.53 10.81 4 51419 21559 42548353
Ascites 14.52 10.81 29 51394 56649 42513263
Rheumatoid arthritis 14.40 10.81 18 51405 42422 42527490
Tunnel vision 14.39 10.81 9 51414 592 42569320
Wheezing 14.26 10.81 114 51309 54667 42515245
Dyspnoea 14.18 10.81 661 50762 441960 42127952
Gastrooesophageal reflux disease 14.17 10.81 98 51325 44925 42524987
Anxiety 14.11 10.81 211 51212 118349 42451563
Metamorphopsia 14.02 10.81 9 51414 620 42569292
Ejaculation delayed 13.90 10.81 7 51416 302 42569610
Anaemia 13.65 10.81 247 51176 280031 42289881
Rash pruritic 13.60 10.81 78 51345 33525 42536387
Pancytopenia 13.44 10.81 85 51338 117658 42452254
Musculoskeletal discomfort 13.42 10.81 33 51390 9443 42560469
Intertrigo 13.36 10.81 8 51415 487 42569425
Muscle tightness 13.33 10.81 24 51399 5529 42564383
Leukopenia 13.23 10.81 46 51377 74700 42495212
Double stranded DNA antibody positive 13.21 10.81 6 51417 205 42569707
Dry eye 13.21 10.81 45 51378 15461 42554451
Blood bicarbonate decreased 13.21 10.81 17 51406 2918 42566994
Spinal osteoarthritis 13.11 10.81 31 51392 8655 42561257
Intercepted medication error 13.09 10.81 8 51415 505 42569407
Back pain 13.07 10.81 242 51181 141534 42428378
Spasmodic dysphonia 12.98 10.81 8 51415 513 42569399
Generalised anxiety disorder 12.96 10.81 10 51413 924 42568988
Cerebral microangiopathy 12.95 10.81 6 51417 215 42569697
Haematopoietic stem cell mobilisation 12.86 10.81 7 51416 355 42569557
Cytomegalovirus infection 12.85 10.81 12 51411 32294 42537618
Skin exfoliation 12.81 10.81 90 51333 41463 42528449
Central nervous system inflammation 12.75 10.81 6 51417 223 42569689
Nasopharyngitis 12.66 10.81 156 51267 83840 42486072
Sleep disorder due to a general medical condition 12.61 10.81 48 51375 17405 42552507
Papule 12.50 10.81 24 51399 5802 42564110
Electrocardiogram QRS complex shortened 12.50 10.81 6 51417 233 42569679
Sensory level abnormal 12.46 10.81 4 51419 51 42569861
Therapeutic response unexpected 12.43 10.81 36 51387 11345 42558567
Allergic eosinophilia 12.19 10.81 4 51419 55 42569857
Depression 12.03 10.81 195 51228 111168 42458744
Tendinous contracture 11.97 10.81 5 51418 139 42569773
Impaired quality of life 11.95 10.81 41 51382 14136 42555776
Upper-airway cough syndrome 11.95 10.81 20 51403 4346 42565566
Myalgia 11.82 10.81 172 51251 95908 42474004
Thought blocking 11.71 10.81 5 51418 147 42569765
Pneumocystis jirovecii pneumonia 11.71 10.81 8 51415 25173 42544739
Tachycardia induced cardiomyopathy 11.65 10.81 5 51418 149 42569763
Dermatitis contact 11.50 10.81 20 51403 4483 42565429
Malignant neoplasm progression 11.49 10.81 80 51343 108320 42461592
Foetal exposure during pregnancy 11.45 10.81 25 51398 47286 42522626
Testicular cyst 11.41 10.81 4 51419 68 42569844
Drug level increased 11.31 10.81 9 51414 26191 42543721
Mucosal inflammation 11.22 10.81 27 51396 49347 42520565
Product quality issue 11.18 10.81 47 51376 17835 42552077
Victim of chemical submission 11.17 10.81 5 51418 165 42569747
Intentional self-injury 11.14 10.81 42 51381 15160 42554752
Feeling abnormal 11.13 10.81 131 51292 69655 42500257
Acute respiratory distress syndrome 11.04 10.81 12 51411 30096 42539816
Crying 10.96 10.81 24 51399 6370 42563542
Keratoacanthoma 10.91 10.81 9 51414 915 42568997

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Extra dose administered 480.15 9.92 250 129630 11909 110447510
Accidental exposure to product by child 451.67 9.92 162 129718 3036 110456383
Dermatitis atopic 226.84 9.92 209 129671 25332 110434087
Hand deformity 217.70 9.92 9 129871 218497 110240922
General physical health deterioration 203.26 9.92 124 129756 425171 110034248
Failure of child resistant product closure 200.86 9.92 39 129841 32 110459387
Synovitis 194.67 9.92 42 129838 274050 110185369
Systemic lupus erythematosus 186.80 9.92 36 129844 254302 110205117
Urticaria 185.50 9.92 804 129076 318053 110141366
Pericarditis 183.93 9.92 21 129859 219093 110240326
Contraindicated product administered 182.63 9.92 35 129845 248232 110211187
Helicobacter infection 167.21 9.92 12 129868 181865 110277554
Glossodynia 166.07 9.92 30 129850 221974 110237445
Drug intolerance 157.68 9.92 147 129733 406365 110053054
Wound 156.46 9.92 41 129839 234396 110225023
Pruritus 153.02 9.92 1187 128693 580373 109879046
Muscle injury 150.44 9.92 3 129877 140804 110318615
Off label use 143.98 9.92 1103 128777 1499082 108960337
Treatment failure 143.69 9.92 73 129807 277161 110182258
Folliculitis 138.38 9.92 17 129863 167636 110291783
Drug abuse 128.38 9.92 26 129854 177385 110282034
Human rhinovirus test positive 127.61 9.92 50 129830 1207 110458212
C-reactive protein abnormal 123.84 9.92 7 129873 129688 110329731
Respiratory syncytial virus test positive 122.61 9.92 51 129829 1443 110457976
Cough 116.22 9.92 933 128947 460708 109998711
Drug ineffective 115.79 9.92 1186 128694 1519354 108940065
Infective pulmonary exacerbation of cystic fibrosis 106.88 9.92 108 129772 14663 110444756
Therapeutic product effect decreased 106.21 9.92 79 129801 244237 110215182
Swelling face 104.85 9.92 291 129589 92030 110367389
Lip swelling 103.25 9.92 201 129679 50466 110408953
Sleep disorder due to general medical condition, insomnia type 103.07 9.92 5 129875 105638 110353781
Joint swelling 102.75 9.92 230 129650 442615 110016804
Somnolence 95.93 9.92 638 129242 296811 110162608
Impaired healing 92.98 9.92 58 129822 196659 110262760
Mobility decreased 89.49 9.92 88 129792 237334 110222085
C-reactive protein increased 89.00 9.92 75 129805 217844 110241575
Asthma 88.16 9.92 549 129331 249742 110209677
Arthropathy 86.65 9.92 127 129753 287395 110172024
Anaphylactic reaction 86.34 9.92 313 129567 113987 110345432
Throat irritation 84.13 9.92 191 129689 53361 110406058
Lower respiratory tract infection 83.93 9.92 97 129783 243009 110216410
Product dose omission issue 83.44 9.92 655 129225 321127 110138292
Viral test positive 82.41 9.92 33 129847 845 110458574
Facet joint syndrome 81.93 9.92 9 129871 96819 110362600
Maternal exposure during pregnancy 81.38 9.92 108 129772 254775 110204644
Gastrooesophageal reflux disease 80.62 9.92 421 129459 179555 110279864
Liver injury 78.81 9.92 39 129841 150374 110309045
Nasal congestion 76.67 9.92 272 129608 98010 110361409
Lip dry 75.96 9.92 13 129867 100070 110359349
Angioedema 75.47 9.92 271 129609 98229 110361190
Toxicity to various agents 75.07 9.92 300 129580 480255 109979164
Dizziness 74.45 9.92 1192 128688 697001 109762418
Acute kidney injury 73.12 9.92 442 129438 634988 109824431
Dyspnoea 72.81 9.92 1756 128124 1105116 109354303
Hepatic enzyme increased 70.90 9.92 171 129709 320721 110138698
Chronic spontaneous urticaria 70.26 9.92 38 129842 1955 110457464
Irritable bowel syndrome 70.19 9.92 54 129826 164161 110295258
Pulmonary fibrosis 69.68 9.92 17 129863 102025 110357394
Intentional product use issue 68.52 9.92 116 129764 247790 110211629
Fibromyalgia 68.34 9.92 60 129820 170849 110288570
Rheumatoid arthritis 68.32 9.92 157 129723 299456 110159963
Pneumonia aspiration 66.99 9.92 229 129651 81004 110378415
Ill-defined disorder 66.51 9.92 52 129828 156801 110302618
Rash 66.12 9.92 1341 128539 819623 109639796
Chest discomfort 66.06 9.92 389 129491 173459 110285960
Fatigue 65.21 9.92 1878 128002 1214080 109245339
Oropharyngeal pain 65.16 9.92 323 129557 134953 110324466
Back pain 65.02 9.92 694 129186 370302 110089117
Upper respiratory tract infection 64.27 9.92 315 129565 131013 110328406
Psoriatic arthropathy 64.21 9.92 82 129798 196679 110262740
Wound infection 62.21 9.92 18 129862 96447 110362972
Feeling abnormal 61.50 9.92 393 129487 180318 110279101
Vision blurred 61.39 9.92 307 129573 128715 110330704
Dry skin 61.37 9.92 270 129610 107383 110352036
Cholecystitis chronic 60.72 9.92 65 129815 9435 110449984
Illness 59.51 9.92 222 129658 81949 110377470
Bronchitis 59.42 9.92 351 129529 156681 110302738
Pneumonia haemophilus 59.36 9.92 38 129842 2677 110456742
Tongue biting 59.02 9.92 39 129841 2900 110456519
Emotional distress 58.65 9.92 149 129731 44698 110414721
Impaired quality of life 58.64 9.92 117 129763 29900 110429519
Chills 54.45 9.92 397 129483 190183 110269236
Headache 54.37 9.92 1388 128492 880989 109578430
Myelosuppression 53.26 9.92 22 129858 94318 110365101
Therapeutic product effect incomplete 52.04 9.92 116 129764 223689 110235730
Lung disorder 51.84 9.92 82 129798 179965 110279454
Palpitations 51.57 9.92 342 129538 158870 110300549
Urinary tract infection 50.18 9.92 595 129285 325687 110133732
Peripheral venous disease 50.17 9.92 18 129862 84099 110375320
Butterfly rash 49.52 9.92 31 129849 2100 110457319
COVID-19 48.94 9.92 471 129409 244589 110214830
Alopecia 48.31 9.92 242 129638 364511 110094908
Swelling 48.17 9.92 230 129650 350811 110108608
Nail disorder 47.49 9.92 6 129874 57929 110401490
Mouth haemorrhage 46.92 9.92 68 129812 13420 110445999
Erythema 46.82 9.92 536 129344 290911 110168508
Incorrect dose administered 46.08 9.92 242 129638 103399 110356020
Chest pain 45.98 9.92 658 129222 375717 110083702
Gastrointestinal disorder 45.85 9.92 139 129741 241813 110217606
Blister 45.73 9.92 127 129753 227249 110232170
Eye pruritus 45.07 9.92 111 129769 32664 110426755
Musculoskeletal stiffness 44.08 9.92 174 129706 279648 110179771
Joint range of motion decreased 43.80 9.92 47 129833 121785 110337634
Carbuncle 43.60 9.92 25 129855 1442 110457977
Inflammation 43.43 9.92 102 129778 193136 110266283
Expired product administered 43.05 9.92 51 129829 8269 110451150
Drug interaction 42.95 9.92 378 129502 499805 109959614
Type 2 diabetes mellitus 42.74 9.92 90 129790 177142 110282277
Bursitis 42.53 9.92 54 129826 129864 110329555
Lacrimation increased 41.69 9.92 104 129776 30846 110428573
Grip strength decreased 41.67 9.92 21 129859 80153 110379266
Live birth 41.21 9.92 15 129865 69469 110389950
Pharyngeal swelling 40.90 9.92 60 129820 11972 110447447
Adjustment disorder with depressed mood 40.02 9.92 3 129877 43880 110415539
Seasonal allergy 39.88 9.92 78 129802 19644 110439775
Renal impairment 39.59 9.92 103 129777 188342 110271077
Rhabdomyolysis 39.46 9.92 50 129830 120351 110339068
Eye swelling 39.33 9.92 106 129774 32942 110426477
Drug resistance 39.26 9.92 9 129871 56365 110403054
Onychomadesis 39.26 9.92 4 129876 45659 110413760
Gait inability 38.42 9.92 63 129817 136313 110323106
Thrombocytopenia 38.34 9.92 246 129634 348639 110110780
Anxiety 38.13 9.92 593 129287 344485 110114934
Hypercholesterolaemia 37.39 9.92 31 129849 90806 110368613
Skin exfoliation 36.48 9.92 201 129679 87450 110371969
Syncope 35.49 9.92 379 129501 202157 110257262
Monoclonal immunoglobulin present 35.46 9.92 27 129853 2513 110456906
Head discomfort 34.67 9.92 72 129808 18928 110440491
Throat tightness 34.55 9.92 102 129778 33387 110426032
Lower limb fracture 34.52 9.92 23 129857 75325 110384094
Obesity 34.19 9.92 50 129830 113301 110346118
Gallbladder disorder 34.14 9.92 76 129804 20953 110438466
Myalgia 33.93 9.92 405 129475 221976 110237443
Flushing 33.92 9.92 225 129655 104511 110354908
Insomnia 33.71 9.92 603 129277 359987 110099432
X-ray abnormal 33.66 9.92 3 129877 38114 110421305
Dry eye 33.37 9.92 142 129738 55651 110403768
Swollen tongue 33.34 9.92 150 129730 60212 110399207
Pancytopenia 33.22 9.92 130 129750 209483 110249936
Bone pain 33.13 9.92 158 129722 64975 110394444
Temperature intolerance 32.99 9.92 59 129821 13891 110445528
Liver disorder 32.83 9.92 74 129806 142169 110317250
Rash macular 32.71 9.92 110 129770 38576 110420843
Stomatitis 32.60 9.92 185 129695 270057 110189362
Hepatic cytolysis 32.46 9.92 12 129868 55041 110404378
Overweight 32.42 9.92 39 129841 6425 110452994
Eczema 32.27 9.92 169 129711 72124 110387295
Therapy non-responder 32.27 9.92 87 129793 157220 110302199
Blepharospasm 32.26 9.92 12 129868 54839 110404580
Post cholecystectomy syndrome 32.16 9.92 17 129863 835 110458584
Priapism 32.11 9.92 37 129843 5824 110453595
Multiple organ dysfunction syndrome 31.80 9.92 83 129797 151627 110307792
Autoimmune disorder 31.35 9.92 19 129861 65464 110393955
Tongue injury 30.84 9.92 15 129865 617 110458802
Hypothalamo-pituitary disorder 30.68 9.92 26 129854 2820 110456599
Burning sensation 30.34 9.92 161 129719 69051 110390368
Blood cholesterol increased 29.67 9.92 114 129766 184671 110274748
Deep vein thrombosis 29.47 9.92 272 129608 139615 110319804
Heart rate increased 28.47 9.92 276 129604 143558 110315861
Prescribed underdose 28.40 9.92 21 129859 65153 110394266
Night sweats 28.32 9.92 73 129807 133910 110325509
Crying 28.31 9.92 80 129800 25548 110433871
Delirium 28.20 9.92 74 129806 134951 110324468
Muscle spasms 27.72 9.92 470 129410 277687 110181732
Photosensitivity reaction 27.42 9.92 79 129801 25510 110433909
Hyperkalaemia 27.18 9.92 76 129804 135720 110323699
Sopor 27.18 9.92 5 129875 36541 110422878
Rhinorrhoea 27.12 9.92 210 129670 102456 110356963
Nervousness 27.04 9.92 100 129780 36751 110422668
Hip arthroplasty 27.00 9.92 16 129864 55797 110403622
Medication error 26.68 9.92 52 129828 105314 110354105
Status asthmaticus 26.66 9.92 16 129864 1005 110458414
Nausea 26.23 9.92 1734 128146 1233956 109225463
Victim of chemical submission 26.18 9.92 15 129865 864 110458555
Rash pruritic 26.13 9.92 201 129679 97868 110361551
Infection 25.92 9.92 286 129594 361914 110097505
Pneumonia 25.90 9.92 1268 128612 875446 109583973
Cardiogenic shock 25.60 9.92 18 129862 57320 110402099
Face oedema 25.55 9.92 92 129788 33377 110426042
Hepatic cirrhosis 25.54 9.92 25 129855 67601 110391818
Colitis ulcerative 25.48 9.92 32 129848 77331 110382088
Injection site pain 25.39 9.92 320 129560 177602 110281817
Coma 25.24 9.92 230 129650 117639 110341780
Cytomegalovirus infection 24.43 9.92 17 129863 54427 110404992
Upper-airway cough syndrome 24.28 9.92 56 129824 15801 110443618
Red blood cell sedimentation rate increased 24.14 9.92 34 129846 78268 110381151
Body height decreased 24.12 9.92 44 129836 10519 110448900
Post-traumatic stress disorder 24.04 9.92 34 129846 6562 110452857
Tinnitus 23.97 9.92 137 129743 60403 110399016
Thrombotic microangiopathy 23.93 9.92 3 129877 29146 110430273
Lupus-like syndrome 23.87 9.92 9 129871 40783 110418636
Hepatocellular injury 23.82 9.92 15 129865 50627 110408792
Exposure during pregnancy 23.35 9.92 109 129771 167315 110292104
Urticaria pressure 23.27 9.92 7 129873 73 110459346
Malignant neoplasm progression 22.99 9.92 116 129764 174451 110284968
Allergy test positive 22.90 9.92 14 129866 909 110458510
Rhinitis allergic 22.87 9.92 59 129821 17863 110441556
Skin swelling 22.84 9.92 37 129843 8043 110451376
Periorbital oedema 22.70 9.92 42 129838 10150 110449269
Lactic acidosis 22.48 9.92 47 129833 92764 110366655
Prescribed overdose 22.37 9.92 43 129837 87538 110371881
Essential hypertension 22.27 9.92 36 129844 7811 110451608
White blood cell count decreased 22.27 9.92 386 129494 229004 110230415
Hypersomnia 22.16 9.92 78 129802 27983 110431436
Condition aggravated 22.05 9.92 676 129204 734160 109725259
Injection site rash 21.98 9.92 69 129811 23350 110436069
Skin disorder 21.75 9.92 104 129776 42809 110416610
Cholelithiasis 21.60 9.92 138 129742 63284 110396135
Product use issue 21.55 9.92 248 129632 311447 110147972
Ocular hyperaemia 21.23 9.92 97 129783 39189 110420230
Gallbladder injury 20.93 9.92 15 129865 1273 110458146
Cellulitis 20.77 9.92 233 129647 125783 110333636
Confusional state 20.64 9.92 407 129473 468273 109991146
Vitamin B12 increased 20.58 9.92 18 129862 2037 110457382
Interstitial lung disease 20.46 9.92 89 129791 139245 110320174
Limb injury 20.39 9.92 93 129787 37543 110421876
Discomfort 20.33 9.92 158 129722 214549 110244870
Fibrosis 20.26 9.92 34 129846 7608 110451811
Full blood count decreased 20.21 9.92 83 129797 32016 110427403
Sinus disorder 20.12 9.92 84 129796 32644 110426775
Frequent bowel movements 20.08 9.92 33 129847 71357 110388062
Laryngospasm 19.96 9.92 26 129854 4642 110454777
Biliary dyskinesia 19.93 9.92 19 129861 2402 110457017
Joint noise 19.47 9.92 27 129853 5116 110454303
Diarrhoea 19.20 9.92 1570 128310 1137935 109321484
Gastrointestinal mucosal necrosis 19.11 9.92 8 129872 230 110459189
Loss of personal independence in daily activities 19.01 9.92 101 129779 149919 110309500
Sinus headache 18.96 9.92 29 129851 6003 110453416
Therapy partial responder 18.82 9.92 10 129870 37051 110422368
Drug level increased 18.77 9.92 17 129863 47702 110411717
Ear discomfort 18.65 9.92 41 129839 11208 110448211
Mast cell activation syndrome 18.65 9.92 15 129865 1513 110457906
Spinal disorder 18.60 9.92 42 129838 11686 110447733
Peripheral blood stem cell apheresis 18.56 9.92 7 129873 152 110459267
Multiple lentigines syndrome 18.55 9.92 8 129872 248 110459171
Product administration interrupted 18.54 9.92 41 129839 11251 110448168
Spinal osteoarthritis 18.51 9.92 59 129821 20124 110439295
Suicidal ideation 18.46 9.92 180 129700 93757 110365662
Influenza 18.42 9.92 290 129590 168811 110290608
Emotional disorder 18.40 9.92 51 129829 16109 110443310
Eye irritation 18.37 9.92 83 129797 33369 110426050
Electric shock 18.29 9.92 16 129864 1812 110457607
Adverse event 18.20 9.92 66 129814 108743 110350676
Feeling hot 18.11 9.92 175 129705 90931 110368488
Sinusitis 17.97 9.92 466 129414 296222 110163197
Hot flush 17.96 9.92 136 129744 65900 110393519
Agranulocytosis 17.89 9.92 28 129852 61732 110397687
Dactylitis 17.64 9.92 23 129857 4110 110455309
Cystoid macular oedema 17.62 9.92 19 129861 2781 110456638
Rheumatoid factor increased 17.55 9.92 18 129862 2487 110456932
Acute respiratory distress syndrome 17.52 9.92 22 129858 53176 110406243
Infusion site swelling 17.52 9.92 37 129843 9840 110449579
Rhinovirus infection 17.36 9.92 41 129839 11748 110447671
Onychomycosis 17.33 9.92 12 129868 38519 110420900
Leukopenia 17.32 9.92 103 129777 148688 110310731
Lethargy 17.27 9.92 177 129703 93399 110366020
Allergic cystitis 17.24 9.92 3 129877 0 110459419
Blood pressure systolic abnormal 17.24 9.92 4 129876 24846 110434573
Breast pain 17.21 9.92 37 129843 9963 110449456
Tinea pedis 17.20 9.92 19 129861 2856 110456563
Hepatotoxicity 17.20 9.92 30 129850 63370 110396049
Granulocyte count increased 17.17 9.92 16 129864 1967 110457452
Neuropathy peripheral 17.16 9.92 301 129579 178976 110280443
Cystitis noninfective 17.11 9.92 15 129865 1703 110457716
Product label confusion 17.08 9.92 3 129877 22674 110436745
Infusion related reaction 17.08 9.92 330 129550 380832 110078587
Transplant rejection 16.95 9.92 4 129876 24563 110434856
Anxiety disorder 16.94 9.92 25 129855 5015 110454404
Arthropod bite 16.89 9.92 36 129844 9635 110449784
Skin discolouration 16.87 9.92 107 129773 48939 110410480
Acquired haemophilia 16.81 9.92 18 129862 2613 110456806
Abdominal discomfort 16.74 9.92 344 129536 393514 110065905
Cataract subcapsular 16.72 9.92 13 129867 1248 110458171
Eye pain 16.44 9.92 108 129772 49991 110409428
Musculoskeletal pain 16.27 9.92 137 129743 182886 110276533
Blood immunoglobulin A increased 16.24 9.92 14 129866 1554 110457865
Surgery 16.07 9.92 93 129787 41190 110418229
Posterior reversible encephalopathy syndrome 15.97 9.92 10 129870 33851 110425568
Pneumocystis jirovecii pneumonia 15.90 9.92 16 129864 42719 110416700
Altered state of consciousness 15.87 9.92 27 129853 57599 110401820
Depression 15.75 9.92 486 129394 316849 110142570
Polyneuropathy 15.73 9.92 9 129871 32003 110427416
Dry throat 15.69 9.92 34 129846 9204 110450215
Cerebral haemorrhage 15.65 9.92 33 129847 64935 110394484
Carotid artery disease 15.62 9.92 16 129864 2207 110457212
Wrist deformity 15.60 9.92 19 129861 3170 110456249
Non-cardiac chest pain 15.60 9.92 36 129844 10162 110449257
Cardiac failure 15.55 9.92 143 129737 187483 110271936
Glomerular filtration rate increased 15.52 9.92 15 129865 1930 110457489
Hyperlipidaemia 15.45 9.92 83 129797 35765 110423654
Inappropriate schedule of product administration 15.44 9.92 330 129550 203307 110256112
Thermal burn 15.44 9.92 31 129849 7957 110451462
Haematotoxicity 15.43 9.92 3 129877 21079 110438340
Coronary artery disease 15.40 9.92 140 129740 71550 110387869
Status epilepticus 15.34 9.92 9 129871 31562 110427857
Haemophagocytic lymphohistiocytosis 15.33 9.92 9 129871 31550 110427869
Therapeutic response unexpected 15.29 9.92 62 129818 23781 110435638
Bed bug infestation 15.22 9.92 5 129875 71 110459348
Osteoarthritis 15.21 9.92 139 129741 182484 110276935
Pathergy reaction 15.15 9.92 5 129875 72 110459347
Serotonin syndrome 15.14 9.92 29 129851 59124 110400295
Coeliac disease 15.14 9.92 17 129863 43170 110416249
Bone marrow failure 15.13 9.92 28 129852 57820 110401599
Laryngeal pain 15.07 9.92 26 129854 5949 110453470
Anaphylactoid reaction 15.04 9.92 28 129852 6798 110452621
Overdose 15.02 9.92 189 129691 233605 110225814
Oral pruritus 14.99 9.92 19 129861 3301 110456118
Circulatory collapse 14.99 9.92 17 129863 42976 110416443
Sinus operation 14.93 9.92 18 129862 2973 110456446
Conduction disorder 14.92 9.92 21 129859 4034 110455385
Dermatitis contact 14.87 9.92 43 129837 13910 110445509
Hepatic failure 14.87 9.92 37 129843 68702 110390717
Tinea infection 14.84 9.92 13 129867 1475 110457944
Knee arthroplasty 14.81 9.92 34 129846 64914 110394505
Neuroleptic malignant syndrome 14.80 9.92 11 129869 34048 110425371
Depressed mood 14.76 9.92 122 129758 60687 110398732
Injection site erythema 14.56 9.92 172 129708 94004 110365415
Oedema 14.53 9.92 167 129713 209809 110249610
Flatulence 14.52 9.92 108 129772 52041 110407378
Middle insomnia 14.51 9.92 55 129825 20447 110438972
Exposure via skin contact 14.48 9.92 41 129839 13106 110446313
Rotator cuff syndrome 14.42 9.92 48 129832 16746 110442673
Septic shock 14.41 9.92 117 129763 157411 110302008
Ventricular hypertrophy 14.41 9.92 28 129852 7017 110452402
Diabetic retinal oedema 14.37 9.92 8 129872 436 110458983
Bacterial test positive 14.29 9.92 30 129850 7947 110451472
Normal newborn 14.27 9.92 4 129876 21892 110437527
Stab wound 14.06 9.92 7 129873 303 110459116
Migraine without aura 14.06 9.92 9 129871 634 110458785
Vasospasm 14.05 9.92 13 129867 1583 110457836
Burns first degree 14.03 9.92 4 129876 34 110459385
Cytokine release syndrome 13.95 9.92 135 129745 70171 110389248
Increased appetite 13.94 9.92 44 129836 14933 110444486
Bone density decreased 13.91 9.92 46 129834 15996 110443423
Inflammatory bowel disease 13.89 9.92 28 129852 7206 110452213
Ligament sprain 13.86 9.92 46 129834 16022 110443397
Dermatitis 13.77 9.92 67 129813 27770 110431649
Transient ischaemic attack 13.77 9.92 125 129755 63857 110395562
Epilepsy 13.53 9.92 66 129814 100143 110359276
Bezoar 13.47 9.92 20 129860 4034 110455385
Product dose omission in error 13.41 9.92 59 129821 23453 110435966
Red blood cell sedimentation rate abnormal 13.38 9.92 6 129874 24503 110434916
Musculoskeletal discomfort 13.38 9.92 59 129821 23479 110435940
Neurological examination normal 13.36 9.92 4 129876 41 110459378
Skin oedema 13.35 9.92 14 129866 1985 110457434
Heart rate decreased 13.31 9.92 51 129829 82705 110376714
Wrong technique in product usage process 13.27 9.92 159 129721 87189 110372230
Back injury 13.25 9.92 22 129858 47377 110412042
Vertebral lateral recess stenosis 13.22 9.92 7 129873 345 110459074
Palmar erythema 13.22 9.92 15 129865 2323 110457096
Pharyngeal dystonia 13.11 9.92 4 129876 44 110459375
Swelling of eyelid 13.07 9.92 26 129854 6627 110452792
Urticaria thermal 13.04 9.92 8 129872 523 110458896
Oesophageal adenocarcinoma recurrent 13.02 9.92 4 129876 45 110459374
Psoriasis 13.02 9.92 234 129646 139759 110319660
Shock haemorrhagic 12.91 9.92 8 129872 27239 110432180
Infusion site erythema 12.89 9.92 37 129843 11922 110447497
Aspartate aminotransferase 12.87 9.92 10 129870 959 110458460
Foreign body in reproductive tract 12.83 9.92 10 129870 964 110458455
Parkinsonism 12.81 9.92 5 129875 22182 110437237
Ligamentum flavum hypertrophy 12.80 9.92 7 129873 368 110459051
Red blood cell count decreased 12.79 9.92 126 129754 65797 110393622
Accident at home 12.78 9.92 6 129874 228 110459191
Patellofemoral pain syndrome 12.74 9.92 8 129872 545 110458874
Osteoarthropathy 12.73 9.92 7 129873 372 110459047
Injection site discolouration 12.70 9.92 31 129849 9072 110450347
Gastritis 12.64 9.92 107 129773 53592 110405827
Influenza like illness 12.60 9.92 159 129721 88253 110371166
Infusion site pain 12.56 9.92 47 129833 17372 110442047
Blood alkaline phosphatase increased 12.54 9.92 133 129747 70802 110388617
Vitamin D deficiency 12.50 9.92 49 129831 18503 110440916
Cystic fibrosis 12.48 9.92 21 129859 4710 110454709
Mood altered 12.47 9.92 54 129826 21321 110438098
Meniscus injury 12.46 9.92 28 129852 7765 110451654
Throat clearing 12.46 9.92 20 129860 4313 110455106
Frustration tolerance decreased 12.46 9.92 30 129850 8701 110450718
Therapeutic response shortened 12.41 9.92 68 129812 29515 110429904
Pharyngeal oedema 12.41 9.92 45 129835 16383 110443036
PO2 increased 12.39 9.92 12 129868 1547 110457872
Multiple allergies 12.32 9.92 37 129843 12226 110447193
Acute sinusitis 12.27 9.92 22 129858 5189 110454230
Sedation complication 12.27 9.92 4 129876 19851 110439568
Dysgeusia 12.27 9.92 131 129749 69854 110389565
Product availability issue 12.23 9.92 28 129852 7862 110451557
Complication of device insertion 12.22 9.92 30 129850 8808 110450611
Skin fissures 12.20 9.92 59 129821 24399 110435020
Exposure to toxic agent 12.17 9.92 38 129842 12820 110446599
Skin necrosis 12.17 9.92 5 129875 21507 110437912
Epistaxis 12.15 9.92 218 129662 130154 110329265
Liver function test increased 12.14 9.92 58 129822 88490 110370929
Sinus congestion 12.11 9.92 69 129811 30390 110429029
Taste disorder 12.07 9.92 38 129842 65349 110394070
Injection site urticaria 12.04 9.92 46 129834 17169 110442250
Nasal discomfort 11.96 9.92 24 129856 6157 110453262
Osteonecrosis of jaw 11.89 9.92 24 129856 47993 110411426
Haemodynamic instability 11.88 9.92 6 129874 22882 110436537
Haematopoietic stem cell mobilisation 11.86 9.92 7 129873 426 110458993
Lymphopenia 11.84 9.92 18 129862 40152 110419267
Sciatica 11.82 9.92 62 129818 92337 110367082
Diverticulitis 11.74 9.92 105 129775 53417 110406002
Skin irritation 11.74 9.92 44 129836 16275 110443144
Borderline personality disorder 11.66 9.92 10 129870 1102 110458317
Pain in extremity 11.64 9.92 691 129189 486427 109972992
Injection site scab 11.60 9.92 8 129872 638 110458781
Rash erythematous 11.59 9.92 147 129733 81685 110377734
Obsessive-compulsive disorder 11.56 9.92 26 129854 7215 110452204
Papule 11.56 9.92 32 129848 10101 110449318
Ear pruritus 11.52 9.92 26 129854 7234 110452185
Vaginitis gardnerella 11.51 9.92 4 129876 68 110459351
Skin warm 11.51 9.92 30 129850 9140 110450279
Pneumonitis 11.49 9.92 139 129741 76392 110383027
No adverse event 11.48 9.92 135 129745 73704 110385715
Neurotoxicity 11.42 9.92 20 129860 42187 110417232
Multiple sclerosis 11.41 9.92 60 129820 25638 110433781
Joint dislocation 11.41 9.92 14 129866 34176 110425243
Panic disorder 11.39 9.92 17 129863 3444 110455975
Mitral valve prolapse 11.36 9.92 14 129866 2364 110457055
Eye discharge 11.36 9.92 29 129851 8725 110450694
Cerebrovascular accident 11.34 9.92 286 129594 180998 110278421
Allergic eosinophilia 11.30 9.92 4 129876 72 110459347
Mouth swelling 11.29 9.92 26 129854 7328 110452091
Oedema mouth 11.21 9.92 16 129864 3114 110456305
Oropharyngeal discomfort 11.18 9.92 32 129848 10295 110449124
Intervertebral disc protrusion 11.18 9.92 63 129817 27635 110431784
Incorrect dosage administered 11.15 9.92 18 129862 3900 110455519
Skin burning sensation 11.14 9.92 53 129827 21772 110437647
PCO2 decreased 11.09 9.92 16 129864 3145 110456274
Bronchial hyperreactivity 11.09 9.92 17 129863 3527 110455892
Chronic obstructive pulmonary disease 11.06 9.92 185 129695 108973 110350446
Initial insomnia 11.06 9.92 32 129848 10357 110449062
Skin discomfort 11.03 9.92 13 129867 2097 110457322
Limb mass 10.98 9.92 18 129862 3951 110455468
Conjunctival pigmentation 10.96 9.92 4 129876 79 110459340
Reflux gastritis 10.94 9.92 11 129869 1485 110457934
Schizophrenia 10.92 9.92 6 129874 21820 110437599
Ear swelling 10.90 9.92 13 129867 2123 110457296
White blood cells urine positive 10.90 9.92 26 129854 7498 110451921
Acute myocardial infarction 10.82 9.92 148 129732 83629 110375790
Pulmonary embolism 10.78 9.92 329 129551 214145 110245274
Gluten sensitivity 10.77 9.92 7 129873 506 110458913
Aneurysm 10.76 9.92 19 129861 4427 110454992
Skin plaque 10.73 9.92 36 129844 12609 110446810
Biliary sepsis 10.72 9.92 12 129868 1831 110457588
Dysphagia 10.72 9.92 246 129634 153354 110306065
Autoimmune hepatitis 10.72 9.92 40 129840 14764 110444655
Head deformity 10.68 9.92 4 129876 85 110459334
Renal cyst 10.67 9.92 46 129834 18126 110441293
Uterine cyst 10.59 9.92 6 129874 338 110459081
Muscular weakness 10.56 9.92 217 129663 248251 110211168
Exostosis 10.53 9.92 24 129856 45932 110413487
Sneezing 10.53 9.92 69 129811 31915 110427504
Cervical spinal stenosis 10.48 9.92 15 129865 2927 110456492
Snoring 10.43 9.92 24 129856 6760 110452659
Bronchospasm 10.42 9.92 66 129814 30173 110429246
Sinus pain 10.40 9.92 22 129858 5857 110453562
Toe operation 10.39 9.92 9 129871 1005 110458414
Allergy to animal 10.34 9.92 12 129868 1904 110457515
Neurological examination abnormal 10.31 9.92 8 129872 766 110458653
Tuberculosis 10.27 9.92 4 129876 17770 110441649
Somnambulism 10.23 9.92 23 129857 6382 110453037
Cholestasis 10.22 9.92 40 129840 64478 110394941
Agitation 10.17 9.92 188 129692 112863 110346556
Irritability 10.08 9.92 93 129787 47716 110411703
Chromaturia 10.07 9.92 64 129816 29296 110430123
Drug ineffective for unapproved indication 10.05 9.92 75 129805 102763 110356656
Melaena 10.04 9.92 44 129836 68713 110390706
Intervertebral disc degeneration 10.03 9.92 45 129835 18040 110441379
Haematochezia 10.03 9.92 87 129793 115437 110343982
Hiatus hernia 9.98 9.92 61 129819 27545 110431874

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R06AX13 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Other antihistamines for systemic use
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:37955 H<small><sub>1</sub></small>-receptor antagonist
CHEBI has role CHEBI:48873 cholinergic antagonist
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:50857 anti-allergic agent
CHEBI has role CHEBI:65023 anti-asthmatic agent
CHEBI has role CHEBI:176497 geroprotector
MeSH PA D000982 Antipruritics
MeSH PA D003879 Dermatologic Agents
MeSH PA D006633 Histamine Antagonists
MeSH PA D006634 Histamine H1 Antagonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018926 Anti-Allergic Agents
MeSH PA D039563 Histamine H1 Antagonists, Non-Sedating

Related Drugs by ATC class:

R06AX Other antihistamines for systemic use 26 drugs
acrivastineantazolineastemizoleazatadineazelastinebamipinebilastinecyproheptadinedeptropinedesloratadineebastineepinastine show all 26 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Vasomotor rhinitis indication 8229003 DOID:4730
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Sneezing indication 76067001
Common cold indication 82272006 DOID:10459
Chronic idiopathic urticaria indication 302162004
Seasonal allergic rhinitis indication 367498001
Allergic conjunctivitis indication 473460002 DOID:11204
Bone pain after neupogen off-label use 12584003
Urticaria off-label use 126485001
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Hepatic failure contraindication 59927004
Diabetes mellitus contraindication 73211009 DOID:9351
Kidney disease contraindication 90708001 DOID:557
Impaired renal function disorder contraindication 197663003
Disease of liver contraindication 235856003 DOID:409
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Hypertensive urgency contraindication 443482000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.43 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Histamine H1 receptor GPCR ANTAGONIST Ki 6.97 WOMBAT-PK CHEMBL
Multidrug resistance protein 1 Transporter Ki 4.94 WOMBAT-PK
5-hydroxytryptamine receptor 2B GPCR Ki 6.81 DRUG MATRIX
Nuclear receptor subfamily 1 group I member 2 Nuclear hormone receptor EC50 5.52 CHEMBL
Cytochrome P450 2C19 Enzyme IC50 7.80 DRUG MATRIX
Potassium channel subfamily K member 9 Ion channel IC50 4.20 CHEMBL
Bile acid receptor Nuclear hormone receptor IC50 5.51 CHEMBL
Sodium-dependent neutral amino acid transporter B(0)AT2 Transporter IC50 5.40 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 6.77 WOMBAT-PK
Transient receptor potential cation channel subfamily V member 2 Ion channel BLOCKER IC50 5.52 IUPHAR
Histamine H1 receptor GPCR Kd 7.14 CHEMBL
Histamine H1 receptor GPCR Ki 6.46 CHEMBL

External reference:

IDSource
4020716 VUID
N0000148306 NUI
D00364 KEGG_DRUG
4020716 VANDF
C0065180 UMLSCUI
CHEBI:6538 CHEBI
CHEMBL998 ChEMBL_ID
DB00455 DRUGBANK_ID
D017336 MESH_DESCRIPTOR_UI
3957 PUBCHEM_CID
7216 IUPHAR_LIGAND_ID
5864 INN_ID
7AJO3BO7QN UNII
203576 RXNORM
191 MMSL
45829 MMSL
4994 MMSL
d03050 MMSL
003909 NDDF
015760 NDDF
108652002 SNOMEDCT_US
386884002 SNOMEDCT_US
7AJO3BO7QN INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
allergy relief HUMAN OTC DRUG LABEL 1 0067-6066 TABLET 10 mg ORAL NDA 15 sections
allergy relief HUMAN OTC DRUG LABEL 1 0067-6122 TABLET 10 mg ORAL NDA 15 sections
good sense allergy relief HUMAN OTC DRUG LABEL 1 0113-0612 TABLET 10 mg ORAL ANDA 15 sections
Good Sense childrens allergy relief HUMAN OTC DRUG LABEL 1 0113-0671 SOLUTION 5 mg ORAL ANDA 14 sections
good sense childrens allergy relief HUMAN OTC DRUG LABEL 1 0113-1019 TABLET, CHEWABLE 5 mg ORAL ANDA 15 sections
good sense allergy relief HUMAN OTC DRUG LABEL 1 0113-1191 TABLET, ORALLY DISINTEGRATING 10 mg ORAL ANDA 15 sections
good sense allergy relief HUMAN OTC DRUG LABEL 1 0113-1612 TABLET 10 mg ORAL ANDA 15 sections
good sense childrens allergy relief HUMAN OTC DRUG LABEL 1 0113-1719 SOLUTION 5 mg ORAL ANDA 14 sections
Allergy and Congestion Relief HUMAN OTC DRUG LABEL 2 0113-2007 TABLET, FILM COATED, EXTENDED RELEASE 5 mg ORAL ANDA 14 sections
perrigo allergy d HUMAN OTC DRUG LABEL 2 0113-7777 TABLET, FILM COATED, EXTENDED RELEASE 5 mg ORAL ANDA 15 sections
allergy d HUMAN OTC DRUG LABEL 2 0113-9004 TABLET, EXTENDED RELEASE 10 mg ORAL ANDA 15 sections
good sense allergy relief HUMAN OTC DRUG LABEL 1 0113-9755 TABLET, ORALLY DISINTEGRATING 10 mg ORAL ANDA 15 sections
Loratadine HUMAN OTC DRUG LABEL 1 0363-0522 TABLET 10 mg ORAL ANDA 15 sections
Loratadine HUMAN OTC DRUG LABEL 1 0363-0527 TABLET, ORALLY DISINTEGRATING 10 mg ORAL ANDA 15 sections
Loratadine and Pseudoephedrine HUMAN OTC DRUG LABEL 2 0363-0725 TABLET, FILM COATED, EXTENDED RELEASE 10 mg ORAL ANDA 16 sections
Loratadine HUMAN OTC DRUG LABEL 1 0363-0752 TABLET, CHEWABLE 5 mg ORAL ANDA 16 sections
Wal-itin HUMAN OTC DRUG LABEL 1 0363-0754 TABLET, CHEWABLE 5 mg ORAL ANDA 16 sections
Loratadine HUMAN OTC DRUG LABEL 1 0363-0771 SOLUTION 5 mg ORAL ANDA 16 sections
Loratadine HUMAN OTC DRUG LABEL 1 0363-0771 SOLUTION 5 mg ORAL ANDA 16 sections
Indoor Outdoor Allergy Relief HUMAN OTC DRUG LABEL 1 0363-0858 TABLET 10 mg ORAL ANDA 14 sections
allergy relief HUMAN OTC DRUG LABEL 1 0363-1612 TABLET 10 mg ORAL ANDA 15 sections
WAL-ITIN HUMAN OTC DRUG LABEL 1 0363-1686 CAPSULE, LIQUID FILLED 10 mg ORAL ANDA 16 sections
Allergy Relief D HUMAN OTC DRUG LABEL 2 0363-2010 TABLET, EXTENDED RELEASE 10 mg ORAL ANDA 15 sections
Wal-itin Allergy Relief HUMAN OTC DRUG LABEL 1 0363-2085 SOLUTION 5 mg ORAL ANDA 15 sections
Childrens Wal-itin HUMAN OTC DRUG LABEL 1 0363-2092 SOLUTION 5 mg ORAL ANDA 16 sections
Childrens Walitin HUMAN OTC DRUG LABEL 1 0363-2108 SOLUTION 5 mg ORAL ANDA 16 sections
Childrens Loratadine Sugar Free HUMAN OTC DRUG LABEL 1 0363-2131 SOLUTION 5 mg ORAL ANDA 16 sections
CHILDRENS LORATADINE ODT Human OTC Drug Label 1 0363-4020 TABLET, ORALLY DISINTEGRATING 10 mg ORAL ANDA 15 sections
allergy relief d 12 HUMAN OTC DRUG LABEL 2 0363-7023 TABLET, FILM COATED, EXTENDED RELEASE 5 mg ORAL ANDA 15 sections
Wal-itin HUMAN OTC DRUG LABEL 1 0363-9150 TABLET 10 mg ORAL ANDA 14 sections