Stem definition | Drug id | CAS RN |
---|---|---|
histamine-H1 receptor antagonists, tricyclic compounds | 1605 | 79794-75-5 |
Dose | Unit | Route |
---|---|---|
10 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.01 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 5 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.44 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 40 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
April 12, 1993 | FDA | BAYER HEALTHCARE LLC |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Extra dose administered | 363.22 | 9.83 | 169 | 75093 | 4538 | 46606262 |
Accidental exposure to product by child | 187.69 | 9.83 | 70 | 75192 | 1053 | 46609747 |
Gastrooesophageal reflux disease | 130.54 | 9.83 | 336 | 74926 | 74008 | 46536792 |
Failure of child resistant product closure | 117.36 | 9.83 | 23 | 75239 | 9 | 46610791 |
Drug ineffective | 103.28 | 9.83 | 656 | 74606 | 677182 | 45933618 |
Rheumatoid arthritis | 102.19 | 9.83 | 143 | 75119 | 240072 | 46370728 |
Pneumonia aspiration | 98.24 | 9.83 | 180 | 75082 | 31425 | 46579375 |
Urticaria | 96.38 | 9.83 | 411 | 74851 | 117481 | 46493319 |
Contraindicated product administered | 86.15 | 9.83 | 13 | 75249 | 79934 | 46530866 |
Toxicity to various agents | 74.21 | 9.83 | 143 | 75119 | 211623 | 46399177 |
Acute kidney injury | 69.71 | 9.83 | 175 | 75087 | 235680 | 46375120 |
Sinusitis | 69.37 | 9.83 | 401 | 74861 | 129367 | 46481433 |
Drug intolerance | 69.24 | 9.83 | 81 | 75181 | 146968 | 46463832 |
Asthma | 65.63 | 9.83 | 307 | 74955 | 91235 | 46519565 |
Drug abuse | 62.46 | 9.83 | 13 | 75249 | 63395 | 46547405 |
Treatment failure | 58.59 | 9.83 | 39 | 75223 | 93048 | 46517752 |
Synovitis | 57.20 | 9.83 | 14 | 75248 | 61061 | 46549739 |
Cholecystitis chronic | 53.60 | 9.83 | 75 | 75187 | 10424 | 46600376 |
Pruritus | 51.01 | 9.83 | 606 | 74656 | 241746 | 46369054 |
Somnolence | 50.69 | 9.83 | 428 | 74834 | 156093 | 46454707 |
Maternal exposure during pregnancy | 48.78 | 9.83 | 56 | 75206 | 102493 | 46508307 |
Off label use | 48.56 | 9.83 | 386 | 74876 | 379455 | 46231345 |
Dizziness | 45.90 | 9.83 | 787 | 74475 | 339627 | 46271173 |
Seasonal allergy | 45.34 | 9.83 | 79 | 75183 | 13255 | 46597545 |
Infective pulmonary exacerbation of cystic fibrosis | 40.69 | 9.83 | 67 | 75195 | 10740 | 46600060 |
Butterfly rash | 40.31 | 9.83 | 23 | 75239 | 951 | 46609849 |
Anxiety | 39.58 | 9.83 | 458 | 74804 | 181499 | 46429301 |
Pancytopenia | 38.79 | 9.83 | 48 | 75214 | 85010 | 46525790 |
Swelling face | 38.04 | 9.83 | 178 | 75084 | 52881 | 46557919 |
Insomnia | 37.16 | 9.83 | 418 | 74844 | 164506 | 46446294 |
General physical health deterioration | 36.45 | 9.83 | 83 | 75179 | 115686 | 46495114 |
Muscle spasms | 35.36 | 9.83 | 328 | 74934 | 122785 | 46488015 |
Systemic lupus erythematosus | 35.07 | 9.83 | 32 | 75230 | 65148 | 46545652 |
Coma | 34.93 | 9.83 | 186 | 75076 | 58163 | 46552637 |
Glossodynia | 34.72 | 9.83 | 14 | 75248 | 44359 | 46566441 |
Joint swelling | 34.53 | 9.83 | 144 | 75118 | 165929 | 46444871 |
Angioedema | 34.32 | 9.83 | 140 | 75122 | 39202 | 46571598 |
Dyspnoea | 34.17 | 9.83 | 1079 | 74183 | 514469 | 46096331 |
Rhinitis allergic | 33.27 | 9.83 | 48 | 75214 | 6860 | 46603940 |
Chest discomfort | 33.08 | 9.83 | 254 | 75008 | 90015 | 46520785 |
Gallbladder disorder | 32.67 | 9.83 | 81 | 75181 | 17417 | 46593383 |
C-reactive protein increased | 32.44 | 9.83 | 28 | 75234 | 58562 | 46552238 |
Palpitations | 31.61 | 9.83 | 262 | 75000 | 94997 | 46515803 |
Multiple organ dysfunction syndrome | 30.77 | 9.83 | 23 | 75239 | 51687 | 46559113 |
Emotional distress | 30.63 | 9.83 | 114 | 75148 | 30593 | 46580207 |
Hand deformity | 30.34 | 9.83 | 9 | 75253 | 34565 | 46576235 |
Sinus disorder | 29.18 | 9.83 | 75 | 75187 | 16488 | 46594312 |
Allergy test positive | 28.93 | 9.83 | 13 | 75249 | 321 | 46610479 |
Rhabdomyolysis | 28.53 | 9.83 | 16 | 75246 | 41893 | 46568907 |
Completed suicide | 28.21 | 9.83 | 130 | 75132 | 145790 | 46465010 |
Multiple allergies | 28.15 | 9.83 | 46 | 75216 | 7325 | 46603475 |
Cough | 27.67 | 9.83 | 523 | 74739 | 229726 | 46381074 |
Injury | 26.79 | 9.83 | 141 | 75121 | 43886 | 46566914 |
Drug interaction | 26.53 | 9.83 | 205 | 75057 | 202889 | 46407911 |
Hyponatraemia | 26.29 | 9.83 | 80 | 75182 | 101252 | 46509548 |
Tinnitus | 26.16 | 9.83 | 101 | 75161 | 27572 | 46583228 |
Headache | 26.08 | 9.83 | 979 | 74283 | 477373 | 46133427 |
Lactic acidosis | 26.04 | 9.83 | 11 | 75251 | 33898 | 46576902 |
Feeling abnormal | 25.93 | 9.83 | 312 | 74950 | 124748 | 46486052 |
Death | 25.87 | 9.83 | 383 | 74879 | 335165 | 46275635 |
Hepatocellular injury | 25.34 | 9.83 | 8 | 75254 | 29514 | 46581286 |
Nasal congestion | 25.22 | 9.83 | 148 | 75114 | 47965 | 46562835 |
Depression | 24.21 | 9.83 | 397 | 74865 | 169707 | 46441093 |
Rash | 24.03 | 9.83 | 748 | 74514 | 355764 | 46255036 |
Therapeutic product effect decreased | 23.80 | 9.83 | 62 | 75200 | 82539 | 46528261 |
Acquired haemophilia | 23.37 | 9.83 | 16 | 75246 | 915 | 46609885 |
Hypersensitivity | 23.34 | 9.83 | 356 | 74906 | 149965 | 46460835 |
Product dose omission issue | 23.14 | 9.83 | 391 | 74871 | 168129 | 46442671 |
Wound | 23.03 | 9.83 | 21 | 75241 | 42781 | 46568019 |
Throat irritation | 22.99 | 9.83 | 100 | 75162 | 28801 | 46581999 |
Periorbital oedema | 22.82 | 9.83 | 34 | 75228 | 5001 | 46605799 |
Expired product administered | 22.72 | 9.83 | 36 | 75226 | 5586 | 46605214 |
Thrombocytopenia | 22.59 | 9.83 | 116 | 75146 | 126465 | 46484335 |
Sopor | 21.87 | 9.83 | 3 | 75259 | 19825 | 46590975 |
Bronchitis | 21.79 | 9.83 | 264 | 74998 | 105715 | 46505085 |
Hyperkalaemia | 21.69 | 9.83 | 30 | 75232 | 50679 | 46560121 |
Tinea pedis | 21.49 | 9.83 | 18 | 75244 | 1395 | 46609405 |
Arthropathy | 21.17 | 9.83 | 68 | 75194 | 84632 | 46526168 |
Malignant neoplasm progression | 20.87 | 9.83 | 46 | 75216 | 64880 | 46545920 |
Upper respiratory tract infection | 20.64 | 9.83 | 174 | 75088 | 63382 | 46547418 |
Hypersomnia | 20.41 | 9.83 | 63 | 75199 | 15376 | 46595424 |
Septic shock | 20.32 | 9.83 | 39 | 75223 | 57854 | 46552946 |
Lip swelling | 20.30 | 9.83 | 88 | 75174 | 25307 | 46585493 |
C-reactive protein abnormal | 19.67 | 9.83 | 5 | 75257 | 21265 | 46589535 |
Cardiac failure | 19.42 | 9.83 | 65 | 75197 | 79883 | 46530917 |
Leukopenia | 19.15 | 9.83 | 52 | 75210 | 68291 | 46542509 |
Biliary dyskinesia | 19.15 | 9.83 | 23 | 75239 | 2750 | 46608050 |
Renal impairment | 19.08 | 9.83 | 59 | 75203 | 74313 | 46536487 |
Wheezing | 18.87 | 9.83 | 149 | 75113 | 53237 | 46557563 |
Sinus headache | 18.86 | 9.83 | 30 | 75232 | 4670 | 46606130 |
Oropharyngeal pain | 18.54 | 9.83 | 192 | 75070 | 73976 | 46536824 |
Fatigue | 18.41 | 9.83 | 1176 | 74086 | 607521 | 46003279 |
Osteonecrosis of jaw | 18.37 | 9.83 | 17 | 75245 | 34385 | 46576415 |
Drug resistance | 18.30 | 9.83 | 3 | 75259 | 17365 | 46593435 |
Anaphylactic reaction | 18.10 | 9.83 | 147 | 75115 | 52965 | 46557835 |
Essential hypertension | 17.98 | 9.83 | 28 | 75234 | 4282 | 46606518 |
Premature baby | 17.25 | 9.83 | 4 | 75258 | 18108 | 46592692 |
Lupus hepatitis | 16.94 | 9.83 | 5 | 75257 | 34 | 46610766 |
Alopecia | 16.78 | 9.83 | 174 | 75088 | 162240 | 46448560 |
Photosensitivity reaction | 16.72 | 9.83 | 52 | 75210 | 12740 | 46598060 |
Therapeutic product effect incomplete | 16.70 | 9.83 | 67 | 75195 | 78086 | 46532714 |
Allergic cystitis | 16.30 | 9.83 | 3 | 75259 | 0 | 46610800 |
Hepatic failure | 16.15 | 9.83 | 18 | 75244 | 33398 | 46577402 |
Gallbladder injury | 15.91 | 9.83 | 15 | 75247 | 1359 | 46609441 |
Nervousness | 15.84 | 9.83 | 89 | 75173 | 28386 | 46582414 |
Chest pain | 15.52 | 9.83 | 383 | 74879 | 175941 | 46434859 |
Foetal exposure during pregnancy | 15.48 | 9.83 | 16 | 75246 | 30731 | 46580069 |
Cholelithiasis | 15.38 | 9.83 | 111 | 75151 | 38570 | 46572230 |
Neutropenia | 15.38 | 9.83 | 152 | 75110 | 143052 | 46467748 |
Basophil count decreased | 15.36 | 9.83 | 6 | 75256 | 103 | 46610697 |
Victim of chemical submission | 15.27 | 9.83 | 8 | 75254 | 279 | 46610521 |
Cystitis noninfective | 15.25 | 9.83 | 12 | 75250 | 851 | 46609949 |
Neuropathy peripheral | 15.17 | 9.83 | 218 | 75044 | 90675 | 46520125 |
Posterior reversible encephalopathy syndrome | 15.12 | 9.83 | 3 | 75259 | 15138 | 46595662 |
Circulatory collapse | 15.09 | 9.83 | 8 | 75254 | 21616 | 46589184 |
Abdominal distension | 14.76 | 9.83 | 182 | 75080 | 73169 | 46537631 |
Dyspepsia | 14.70 | 9.83 | 172 | 75090 | 68300 | 46542500 |
Incorrect dose administered | 14.42 | 9.83 | 124 | 75138 | 45426 | 46565374 |
Exposure to toxic agent | 14.39 | 9.83 | 17 | 75245 | 1997 | 46608803 |
Status asthmaticus | 14.39 | 9.83 | 12 | 75250 | 924 | 46609876 |
Agranulocytosis | 14.35 | 9.83 | 9 | 75253 | 22176 | 46588624 |
Overdose | 14.22 | 9.83 | 101 | 75161 | 101878 | 46508922 |
Migraine | 14.20 | 9.83 | 174 | 75088 | 69852 | 46540948 |
Dry mouth | 14.11 | 9.83 | 143 | 75119 | 54783 | 46556017 |
Throat tightness | 13.89 | 9.83 | 68 | 75194 | 20571 | 46590229 |
Neurological examination abnormal | 13.66 | 9.83 | 7 | 75255 | 233 | 46610567 |
Cardio-respiratory arrest | 13.65 | 9.83 | 50 | 75212 | 59819 | 46550981 |
Diarrhoea | 13.40 | 9.83 | 1061 | 74201 | 558541 | 46052259 |
Sinus congestion | 13.35 | 9.83 | 49 | 75213 | 13060 | 46597740 |
Fracture | 13.21 | 9.83 | 5 | 75257 | 16466 | 46594334 |
Infection | 13.04 | 9.83 | 145 | 75117 | 133447 | 46477353 |
Mobility decreased | 12.91 | 9.83 | 52 | 75210 | 60542 | 46550258 |
Renal failure | 12.86 | 9.83 | 119 | 75143 | 113475 | 46497325 |
Suicidal ideation | 12.71 | 9.83 | 143 | 75119 | 56239 | 46554561 |
Xanthogranuloma | 12.70 | 9.83 | 3 | 75259 | 7 | 46610793 |
Hepatotoxicity | 12.61 | 9.83 | 13 | 75249 | 24996 | 46585804 |
Metastases to liver | 12.59 | 9.83 | 8 | 75254 | 19577 | 46591223 |
Pericarditis | 12.57 | 9.83 | 12 | 75250 | 23915 | 46586885 |
Vision blurred | 12.45 | 9.83 | 189 | 75073 | 79519 | 46531281 |
Feeling hot | 12.40 | 9.83 | 104 | 75158 | 37824 | 46572976 |
Abdominal pain upper | 12.30 | 9.83 | 314 | 74948 | 144991 | 46465809 |
Cytomegalovirus infection | 12.24 | 9.83 | 7 | 75255 | 18137 | 46592663 |
Cyclic vomiting syndrome | 11.94 | 9.83 | 4 | 75258 | 43 | 46610757 |
Burns first degree | 11.69 | 9.83 | 3 | 75259 | 11 | 46610789 |
Acute sinusitis | 11.66 | 9.83 | 22 | 75240 | 3925 | 46606875 |
Incorrect dosage administered | 11.63 | 9.83 | 14 | 75248 | 1677 | 46609123 |
Pneumocystis jirovecii pneumonia | 11.62 | 9.83 | 5 | 75257 | 15243 | 46595557 |
Hypotension | 11.56 | 9.83 | 286 | 74976 | 232303 | 46378497 |
Cataract subcapsular | 11.54 | 9.83 | 9 | 75253 | 630 | 46610170 |
Reflux gastritis | 11.48 | 9.83 | 10 | 75252 | 817 | 46609983 |
Ear congestion | 11.48 | 9.83 | 14 | 75248 | 1701 | 46609099 |
Sleep apnoea syndrome | 11.44 | 9.83 | 68 | 75194 | 22133 | 46588667 |
Hepatic enzyme increased | 11.40 | 9.83 | 81 | 75181 | 81706 | 46529094 |
Upper-airway cough syndrome | 11.30 | 9.83 | 33 | 75229 | 7814 | 46602986 |
Deep vein thrombosis | 11.26 | 9.83 | 186 | 75076 | 79587 | 46531213 |
Red blood cell sedimentation rate abnormal | 11.19 | 9.83 | 4 | 75258 | 13645 | 46597155 |
Mitral valve prolapse | 11.16 | 9.83 | 16 | 75246 | 2273 | 46608527 |
Interstitial lung disease | 11.06 | 9.83 | 47 | 75215 | 53902 | 46556898 |
Hot flush | 11.03 | 9.83 | 113 | 75149 | 43404 | 46567396 |
Nasal oedema | 11.03 | 9.83 | 10 | 75252 | 862 | 46609938 |
Acute hepatic failure | 10.95 | 9.83 | 5 | 75257 | 14716 | 46596084 |
Multiple lentigines syndrome | 10.86 | 9.83 | 6 | 75256 | 233 | 46610567 |
Patellofemoral pain syndrome | 10.83 | 9.83 | 8 | 75254 | 516 | 46610284 |
Head discomfort | 10.80 | 9.83 | 39 | 75223 | 10312 | 46600488 |
Hypoaesthesia | 10.69 | 9.83 | 259 | 75003 | 118610 | 46492190 |
Lower respiratory tract infection | 10.68 | 9.83 | 49 | 75213 | 55040 | 46555760 |
Depressed level of consciousness | 10.66 | 9.83 | 40 | 75222 | 47529 | 46563271 |
Eye swelling | 10.64 | 9.83 | 62 | 75200 | 20041 | 46590759 |
Cluster headache | 10.60 | 9.83 | 8 | 75254 | 533 | 46610267 |
Oesophageal adenocarcinoma recurrent | 10.49 | 9.83 | 3 | 75259 | 18 | 46610782 |
Cholestasis | 10.44 | 9.83 | 17 | 75245 | 26876 | 46583924 |
Bone marrow failure | 10.40 | 9.83 | 20 | 75242 | 29649 | 46581151 |
Torsade de pointes | 10.40 | 9.83 | 43 | 75219 | 12111 | 46598689 |
Contraindicated product prescribed | 10.39 | 9.83 | 9 | 75253 | 730 | 46610070 |
Hypocalcaemia | 10.34 | 9.83 | 17 | 75245 | 26768 | 46584032 |
Paraesthesia | 10.30 | 9.83 | 255 | 75007 | 117182 | 46493618 |
Bezoar | 10.18 | 9.83 | 12 | 75250 | 1407 | 46609393 |
Knee arthroplasty | 10.12 | 9.83 | 14 | 75248 | 23651 | 46587149 |
Myxoedema coma | 10.10 | 9.83 | 7 | 75255 | 408 | 46610392 |
Musculoskeletal stiffness | 10.10 | 9.83 | 105 | 75157 | 97888 | 46512912 |
Eye pruritus | 10.10 | 9.83 | 42 | 75220 | 11856 | 46598944 |
Broad ligament tear | 10.09 | 9.83 | 3 | 75259 | 21 | 46610779 |
Tympanic membrane disorder | 10.02 | 9.83 | 5 | 75257 | 157 | 46610643 |
Status epilepticus | 10.01 | 9.83 | 5 | 75257 | 13974 | 46596826 |
Congenital cystic lung | 9.97 | 9.83 | 3 | 75259 | 22 | 46610778 |
Presbyoesophagus | 9.97 | 9.83 | 3 | 75259 | 22 | 46610778 |
Snoring | 9.94 | 9.83 | 19 | 75243 | 3423 | 46607377 |
Rhinorrhoea | 9.90 | 9.83 | 119 | 75143 | 47546 | 46563254 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Accidental exposure to product by child | 314.25 | 10.65 | 104 | 36328 | 1459 | 29914587 |
Extra dose administered | 269.15 | 10.65 | 109 | 36323 | 2777 | 29913269 |
Failure of child resistant product closure | 91.41 | 10.65 | 18 | 36414 | 16 | 29916030 |
Drug abuse | 64.67 | 10.65 | 11 | 36421 | 82061 | 29833985 |
Urticaria | 53.53 | 10.65 | 167 | 36265 | 54439 | 29861607 |
General physical health deterioration | 44.35 | 10.65 | 34 | 36398 | 99910 | 29816136 |
Drug interaction | 42.81 | 10.65 | 114 | 36318 | 199454 | 29716592 |
Infective pulmonary exacerbation of cystic fibrosis | 42.01 | 10.65 | 52 | 36380 | 8520 | 29907526 |
Completed suicide | 40.27 | 10.65 | 37 | 36395 | 99455 | 29816591 |
Sinusitis | 39.38 | 10.65 | 109 | 36323 | 33236 | 29882810 |
Asthma | 32.14 | 10.65 | 107 | 36325 | 36067 | 29879979 |
Toxicity to various agents | 31.69 | 10.65 | 110 | 36322 | 177073 | 29738973 |
Rash | 31.40 | 10.65 | 364 | 36068 | 191525 | 29724521 |
Fatigue | 29.41 | 10.65 | 550 | 35882 | 320123 | 29595923 |
Throat irritation | 28.46 | 10.65 | 43 | 36389 | 8505 | 29907541 |
Pruritus | 28.44 | 10.65 | 243 | 36189 | 117961 | 29798085 |
Sinus disorder | 27.71 | 10.65 | 36 | 36396 | 6189 | 29909857 |
Cough | 26.00 | 10.65 | 250 | 36182 | 125392 | 29790654 |
Acute kidney injury | 25.96 | 10.65 | 211 | 36221 | 273631 | 29642415 |
Expired product administered | 25.77 | 10.65 | 24 | 36408 | 2845 | 29913201 |
PO2 increased | 22.62 | 10.65 | 12 | 36420 | 573 | 29915473 |
Blood pH decreased | 22.18 | 10.65 | 20 | 36412 | 2275 | 29913771 |
Gastrointestinal mucosal necrosis | 21.64 | 10.65 | 8 | 36424 | 158 | 29915888 |
Chronic spontaneous urticaria | 21.36 | 10.65 | 7 | 36425 | 95 | 29915951 |
Rheumatoid arthritis | 20.98 | 10.65 | 12 | 36420 | 41185 | 29874861 |
Treatment failure | 20.90 | 10.65 | 8 | 36424 | 34671 | 29881375 |
Drug ineffective | 20.63 | 10.65 | 291 | 36141 | 340096 | 29575950 |
Seasonal allergy | 20.40 | 10.65 | 27 | 36405 | 4726 | 29911320 |
Dizziness | 19.82 | 10.65 | 340 | 36092 | 194569 | 29721477 |
Bronchitis | 19.70 | 10.65 | 97 | 36335 | 39028 | 29877018 |
Renal impairment | 19.63 | 10.65 | 46 | 36386 | 84138 | 29831908 |
Ultrasound skull abnormal | 18.61 | 10.65 | 6 | 36426 | 77 | 29915969 |
CADASIL | 18.61 | 10.65 | 6 | 36426 | 77 | 29915969 |
Magnetic resonance imaging spinal abnormal | 18.33 | 10.65 | 6 | 36426 | 81 | 29915965 |
Oral pruritus | 18.05 | 10.65 | 8 | 36424 | 256 | 29915790 |
Visual evoked potentials abnormal | 18.00 | 10.65 | 6 | 36426 | 86 | 29915960 |
Hyperkalaemia | 17.98 | 10.65 | 33 | 36399 | 65977 | 29850069 |
Eye pruritus | 17.93 | 10.65 | 23 | 36409 | 3904 | 29912142 |
Physical examination abnormal | 17.40 | 10.65 | 6 | 36426 | 96 | 29915950 |
Infusion related reaction | 17.27 | 10.65 | 96 | 36336 | 40468 | 29875578 |
Wheezing | 17.24 | 10.65 | 79 | 36353 | 30859 | 29885187 |
Tunnel vision | 17.23 | 10.65 | 9 | 36423 | 416 | 29915630 |
Central nervous system inflammation | 17.06 | 10.65 | 6 | 36426 | 102 | 29915944 |
Double stranded DNULL antibody positive | 16.90 | 10.65 | 6 | 36426 | 105 | 29915941 |
Swelling face | 16.47 | 10.65 | 60 | 36372 | 21144 | 29894902 |
Anxiety | 16.25 | 10.65 | 174 | 36258 | 89697 | 29826349 |
Ejaculation delayed | 16.21 | 10.65 | 7 | 36425 | 210 | 29915836 |
Tension headache | 16.03 | 10.65 | 13 | 36419 | 1280 | 29914766 |
Glossodynia | 15.85 | 10.65 | 20 | 36412 | 3341 | 29912705 |
Saccadic eye movement | 15.67 | 10.65 | 6 | 36426 | 131 | 29915915 |
Off label use | 15.47 | 10.65 | 212 | 36220 | 249078 | 29666968 |
Feeling abnormal | 15.42 | 10.65 | 120 | 36312 | 56636 | 29859410 |
Chest pain | 15.30 | 10.65 | 214 | 36218 | 117413 | 29798633 |
Drug resistance | 15.20 | 10.65 | 3 | 36429 | 20130 | 29895916 |
Upper respiratory tract infection | 15.19 | 10.65 | 70 | 36362 | 27406 | 29888640 |
Gastrooesophageal reflux disease | 14.86 | 10.65 | 78 | 36354 | 32177 | 29883869 |
Interstitial lung disease | 14.76 | 10.65 | 32 | 36400 | 60165 | 29855881 |
Metamorphopsia | 14.66 | 10.65 | 9 | 36423 | 568 | 29915478 |
Rhabdomyolysis | 14.61 | 10.65 | 35 | 36397 | 63545 | 29852501 |
Suicidal ideation | 14.41 | 10.65 | 84 | 36348 | 36030 | 29880016 |
Sleep apnoea syndrome | 14.20 | 10.65 | 49 | 36383 | 16808 | 29899238 |
Migraine | 14.13 | 10.65 | 41 | 36391 | 12833 | 29903213 |
Vision blurred | 14.01 | 10.65 | 93 | 36339 | 41723 | 29874323 |
Lacrimation increased | 13.81 | 10.65 | 28 | 36404 | 6988 | 29909058 |
Leukopenia | 13.64 | 10.65 | 30 | 36402 | 56129 | 29859917 |
Depression | 13.62 | 10.65 | 169 | 36263 | 90268 | 29825778 |
Cerebral microangiopathy | 13.48 | 10.65 | 6 | 36426 | 194 | 29915852 |
Lactic acidosis | 13.35 | 10.65 | 11 | 36421 | 31202 | 29884844 |
Rhinitis allergic | 13.29 | 10.65 | 17 | 36415 | 2877 | 29913169 |
Renal failure | 13.29 | 10.65 | 97 | 36335 | 128869 | 29787177 |
Conduction disorder | 13.22 | 10.65 | 14 | 36418 | 1937 | 29914109 |
Hyponatraemia | 13.18 | 10.65 | 40 | 36392 | 67162 | 29848884 |
Intercepted medication error | 13.16 | 10.65 | 8 | 36424 | 496 | 29915550 |
Heart rate increased | 12.90 | 10.65 | 86 | 36346 | 38635 | 29877411 |
Chest discomfort | 12.82 | 10.65 | 97 | 36335 | 45383 | 29870663 |
Thrombocytopenia | 12.76 | 10.65 | 106 | 36326 | 136938 | 29779108 |
Body height decreased | 12.74 | 10.65 | 19 | 36413 | 3715 | 29912331 |
PCO2 decreased | 12.59 | 10.65 | 12 | 36420 | 1464 | 29914582 |
Septic shock | 12.37 | 10.65 | 38 | 36394 | 63569 | 29852477 |
Burning sensation | 12.27 | 10.65 | 46 | 36386 | 16428 | 29899618 |
Contraindicated product administered | 12.13 | 10.65 | 3 | 36429 | 17228 | 29898818 |
Intentional self-injury | 11.99 | 10.65 | 40 | 36392 | 13492 | 29902554 |
Spinal osteoarthritis | 11.96 | 10.65 | 25 | 36407 | 6374 | 29909672 |
Lipid metabolism disorder | 11.93 | 10.65 | 6 | 36426 | 256 | 29915790 |
Stress at work | 11.64 | 10.65 | 5 | 36427 | 148 | 29915898 |
Convulsions local | 11.62 | 10.65 | 3 | 36429 | 16 | 29916030 |
Lip swelling | 11.58 | 10.65 | 38 | 36394 | 12706 | 29903340 |
Rhinorrhoea | 11.57 | 10.65 | 53 | 36379 | 20701 | 29895345 |
Blood cholesterol increased | 11.51 | 10.65 | 46 | 36386 | 16924 | 29899122 |
Muscle tightness | 11.19 | 10.65 | 20 | 36412 | 4543 | 29911503 |
Upper-airway cough syndrome | 11.03 | 10.65 | 15 | 36417 | 2695 | 29913351 |
Insomnia | 11.02 | 10.65 | 167 | 36265 | 93169 | 29822877 |
Muscle spasms | 11.01 | 10.65 | 124 | 36308 | 64714 | 29851332 |
Bone marrow failure | 10.98 | 10.65 | 12 | 36420 | 29773 | 29886273 |
Melaena | 10.96 | 10.65 | 14 | 36418 | 32423 | 29883623 |
Hepatocellular injury | 10.86 | 10.65 | 9 | 36423 | 25462 | 29890584 |
Metabolic acidosis | 10.86 | 10.65 | 18 | 36414 | 37443 | 29878603 |
Dyspnoea | 10.82 | 10.65 | 502 | 35930 | 332793 | 29583253 |
Chills | 10.81 | 10.65 | 135 | 36297 | 72203 | 29843843 |
Hyperprolactinaemia | 10.71 | 10.65 | 10 | 36422 | 1190 | 29914856 |
Source | Code | Description |
---|---|---|
ATC | R06AX13 | RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Other antihistamines for systemic use |
MeSH PA | D018926 | Anti-Allergic Agents |
MeSH PA | D000982 | Antipruritics |
MeSH PA | D003879 | Dermatologic Agents |
MeSH PA | D018494 | Histamine Agents |
MeSH PA | D006633 | Histamine Antagonists |
MeSH PA | D006634 | Histamine H1 Antagonists |
MeSH PA | D039563 | Histamine H1 Antagonists, Non-Sedating |
MeSH PA | D018377 | Neurotransmitter Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Vasomotor rhinitis | indication | 8229003 | DOID:4730 |
Allergic rhinitis | indication | 61582004 | |
Nasal discharge | indication | 64531003 | |
Nasal congestion | indication | 68235000 | |
Sneezing | indication | 76067001 | |
Common cold | indication | 82272006 | DOID:10459 |
Chronic idiopathic urticaria | indication | 302162004 | |
Seasonal allergic rhinitis | indication | 367498001 | |
Allergic conjunctivitis | indication | 473460002 | DOID:11204 |
Bone pain after neupogen | off-label use | 12584003 | |
Urticaria | off-label use | 126485001 | |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Coronary arteriosclerosis | contraindication | 53741008 | DOID:3393 |
Hepatic failure | contraindication | 59927004 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Impaired renal function disorder | contraindication | 197663003 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Retention of urine | contraindication | 267064002 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Hypertensive urgency | contraindication | 443482000 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 4.43 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Histamine H1 receptor | GPCR | ANTAGONIST | Ki | 6.97 | WOMBAT-PK | CHEMBL | |||
5-hydroxytryptamine receptor 2B | GPCR | Ki | 6.81 | DRUG MATRIX | |||||
Cytochrome P450 2C19 | Enzyme | IC50 | 7.80 | DRUG MATRIX | |||||
Multidrug resistance protein 1 | Transporter | Ki | 4.94 | WOMBAT-PK | |||||
Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 6.77 | WOMBAT-PK | |||||
Nuclear receptor subfamily 1 group I member 2 | Nuclear hormone receptor | EC50 | 5.52 | CHEMBL | |||||
Bile acid receptor | Nuclear hormone receptor | IC50 | 5.51 | CHEMBL | |||||
Sodium-dependent neutral amino acid transporter B(0)AT2 | Transporter | IC50 | 5.40 | CHEMBL | |||||
Histamine H1 receptor | GPCR | Ki | 6.46 | CHEMBL | |||||
Histamine H1 receptor | GPCR | Kd | 7.14 | CHEMBL |
ID | Source |
---|---|
4020716 | VUID |
N0000148306 | NUI |
D00364 | KEGG_DRUG |
4020716 | VANDF |
C0701055 | UMLSCUI |
CHEBI:6538 | CHEBI |
CHEMBL998 | ChEMBL_ID |
D017336 | MESH_DESCRIPTOR_UI |
DB00455 | DRUGBANK_ID |
3957 | PUBCHEM_CID |
7216 | IUPHAR_LIGAND_ID |
5864 | INN_ID |
7AJO3BO7QN | UNII |
203576 | RXNORM |
191 | MMSL |
45829 | MMSL |
4994 | MMSL |
d03050 | MMSL |
003909 | NDDF |
015760 | NDDF |
108652002 | SNOMEDCT_US |
386884002 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
allergy relief | HUMAN OTC DRUG LABEL | 1 | 0067-6066 | TABLET | 10 mg | ORAL | NDA | 15 sections |
allergy relief | HUMAN OTC DRUG LABEL | 1 | 0067-6122 | TABLET | 10 mg | ORAL | NDA | 15 sections |
good sense allergy relief | HUMAN OTC DRUG LABEL | 1 | 0113-0612 | TABLET | 10 mg | ORAL | ANDA | 15 sections |
Good Sense childrens allergy relief | HUMAN OTC DRUG LABEL | 1 | 0113-0671 | SOLUTION | 5 mg | ORAL | ANDA | 14 sections |
good sense childrens allergy relief | HUMAN OTC DRUG LABEL | 1 | 0113-1019 | TABLET, CHEWABLE | 5 mg | ORAL | ANDA | 15 sections |
good sense allergy relief | HUMAN OTC DRUG LABEL | 1 | 0113-1191 | TABLET, ORALLY DISINTEGRATING | 10 mg | ORAL | ANDA | 15 sections |
good sense allergy relief | HUMAN OTC DRUG LABEL | 1 | 0113-1612 | TABLET | 10 mg | ORAL | ANDA | 15 sections |
good sense childrens allergy relief | HUMAN OTC DRUG LABEL | 1 | 0113-1719 | SOLUTION | 5 mg | ORAL | ANDA | 14 sections |
Allergy and Congestion Relief | HUMAN OTC DRUG LABEL | 2 | 0113-2007 | TABLET, FILM COATED, EXTENDED RELEASE | 5 mg | ORAL | ANDA | 14 sections |
basic care childrens allergy relief | HUMAN OTC DRUG LABEL | 1 | 0113-7500 | TABLET, CHEWABLE | 5 mg | ORAL | ANDA | 15 sections |
Basic Care allergy relief | HUMAN OTC DRUG LABEL | 1 | 0113-7612 | TABLET | 10 mg | ORAL | ANDA | 15 sections |
Basic Care Childrens Allergy Relief | HUMAN OTC DRUG LABEL | 1 | 0113-7671 | SOLUTION | 5 mg | ORAL | ANDA | 14 sections |
good sense allergy relief | HUMAN OTC DRUG LABEL | 1 | 0113-9755 | TABLET, ORALLY DISINTEGRATING | 10 mg | ORAL | ANDA | 15 sections |
Childrens Loratadine | HUMAN OTC DRUG LABEL | 1 | 0121-0849 | SOLUTION | 5 mg | ORAL | ANDA | 16 sections |
Loratadine | HUMAN OTC DRUG LABEL | 1 | 0363-0522 | TABLET | 10 mg | ORAL | ANDA | 15 sections |
Loratadine | HUMAN OTC DRUG LABEL | 1 | 0363-0527 | TABLET, ORALLY DISINTEGRATING | 10 mg | ORAL | ANDA | 15 sections |
Wal itin | HUMAN OTC DRUG LABEL | 1 | 0363-0699 | TABLET | 10 mg | ORAL | ANDA | 15 sections |
Loratadine and Pseudoephedrine | HUMAN OTC DRUG LABEL | 2 | 0363-0725 | TABLET, FILM COATED, EXTENDED RELEASE | 10 mg | ORAL | ANDA | 16 sections |
Loratadine | HUMAN OTC DRUG LABEL | 1 | 0363-0752 | TABLET, CHEWABLE | 5 mg | ORAL | ANDA | 16 sections |
Wal-itin | HUMAN OTC DRUG LABEL | 1 | 0363-0754 | TABLET, CHEWABLE | 5 mg | ORAL | ANDA | 16 sections |
Indoor Outdoor Allergy Relief | HUMAN OTC DRUG LABEL | 1 | 0363-0858 | TABLET | 10 mg | ORAL | ANDA | 14 sections |
12 hour allergy and congestion | HUMAN OTC DRUG LABEL | 2 | 0363-1133 | TABLET, FILM COATED, EXTENDED RELEASE | 5 mg | ORAL | ANDA | 14 sections |
WAL-ITIN | HUMAN OTC DRUG LABEL | 1 | 0363-1686 | CAPSULE, LIQUID FILLED | 10 mg | ORAL | ANDA | 9 sections |
Wal-itin Allergy Relief | HUMAN OTC DRUG LABEL | 1 | 0363-2085 | SOLUTION | 5 mg | ORAL | ANDA | 15 sections |
Childrens Wal-itin | HUMAN OTC DRUG LABEL | 1 | 0363-2092 | SOLUTION | 5 mg | ORAL | ANDA | 16 sections |
Childrens Walitin | HUMAN OTC DRUG LABEL | 1 | 0363-2108 | SOLUTION | 5 mg | ORAL | ANDA | 16 sections |
Childrens Loratadine Sugar Free | HUMAN OTC DRUG LABEL | 1 | 0363-2131 | SOLUTION | 5 mg | ORAL | ANDA | 16 sections |
Wal-itin D24 Hour | HUMAN OTC DRUG LABEL | 2 | 0363-2390 | TABLET, EXTENDED RELEASE | 10 mg | ORAL | ANDA | 16 sections |
CHILDRENS LORATADINE ODT | Human OTC Drug Label | 1 | 0363-4020 | TABLET, ORALLY DISINTEGRATING | 10 mg | ORAL | ANDA | 15 sections |
Wal-itin | HUMAN OTC DRUG LABEL | 1 | 0363-9150 | TABLET | 10 mg | ORAL | ANDA | 14 sections |