All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

loratadine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
histamine-H1 receptor antagonists, tricyclic compounds	1605	79794-75-5

Description:

Molecule

Description

Molfile Inchi Smiles Synonyms: loratadine claritin loracert loradex loratidine loratyne

A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness. Molecular weight: 382.89 Formula: C22H23ClN2O2 CLOGP: 5.05 LIPINSKI: 1 HAC: 4 HDO: 0 TPSA: 42.43 ALOGS: -4.46 ROTB: 2 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
10	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.01 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	5 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.44 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	40 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
April 12, 1993	FDA	BAYER HEALTHCARE LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Extra dose administered	289.99	9.83	149	85034	5324	56201560
Rheumatoid arthritis	226.11	9.83	151	85032	382453	55824431
Contraindicated product administered	212.06	9.83	19	85164	186267	56020617
Synovitis	190.39	9.83	14	85169	161291	56045593
Drug ineffective	178.75	9.83	752	84431	918237	55288647
Glossodynia	174.98	9.83	15	85168	152443	56054441
Accidental exposure to product by child	170.84	9.83	65	85118	1108	56205776
Hand deformity	166.67	9.83	9	85174	134483	56072401
Systemic lupus erythematosus	159.96	9.83	38	85145	180040	56026844
Gastrooesophageal reflux disease	152.79	9.83	368	84815	82889	56123995
Drug intolerance	150.32	9.83	109	85074	264709	55942175
Pneumonia aspiration	146.07	9.83	211	84972	32200	56174684
Treatment failure	145.46	9.83	39	85144	170353	56036531
Wound	140.89	9.83	21	85162	138783	56068101
Arthropathy	130.80	9.83	70	85113	200205	56006679
Pericarditis	124.19	9.83	11	85172	108912	56097972
Failure of child resistant product closure	118.81	9.83	23	85160	9	56206875
Joint swelling	116.66	9.83	161	85022	289639	55917245
Urticaria	109.91	9.83	472	84711	144204	56062680
Therapeutic product effect decreased	99.71	9.83	67	85116	169385	56037499
Somnolence	96.19	9.83	495	84688	162918	56043966
Maternal exposure during pregnancy	93.91	9.83	89	85094	189464	56017420
General physical health deterioration	78.31	9.83	85	85098	169925	56036959
Off label use	77.82	9.83	508	84675	555672	55651212
Hepatic enzyme increased	77.49	9.83	87	85096	171297	56035587
Asthma	77.37	9.83	357	84826	112413	56094471
Alopecia	76.38	9.83	211	84972	293247	55913637
Swelling face	72.67	9.83	218	84965	55851	56151033
Helicobacter infection	67.96	9.83	14	85169	73254	56133630
Muscle injury	66.65	9.83	3	85180	52497	56154387
Toxicity to various agents	66.55	9.83	151	85032	224413	55982471
Dizziness	65.88	9.83	863	84320	375277	55831607
Pruritus	62.96	9.83	744	84439	315879	55891005
Coma	62.82	9.83	216	84967	59439	56147445
Swelling	61.91	9.83	173	85010	239598	55967286
Anxiety	60.96	9.83	500	84683	192672	56014212
Drug abuse	58.56	9.83	15	85168	67595	56139289
Cholecystitis chronic	58.51	9.83	73	85110	9675	56197209
Feeling abnormal	57.79	9.83	373	84810	133229	56073655
Folliculitis	56.50	9.83	8	85175	54971	56151913
Infective pulmonary exacerbation of cystic fibrosis	55.34	9.83	65	85118	8092	56198792
Angioedema	54.49	9.83	162	85021	41291	56165593
Lower respiratory tract infection	54.40	9.83	56	85127	114738	56092146
Muscle spasms	54.29	9.83	375	84808	136996	56069888
Insomnia	53.40	9.83	483	84700	191377	56015507
Butterfly rash	52.20	9.83	31	85152	1475	56205409
Cough	52.14	9.83	612	84571	259349	55947535
Sleep disorder due to general medical condition, insomnia type	50.42	9.83	4	85179	43334	56163550
Chest discomfort	49.70	9.83	287	84896	98570	56108314
Lip swelling	49.08	9.83	117	85066	26155	56180729
Dermatitis atopic	47.98	9.83	61	85122	8238	56198646
Headache	47.46	9.83	1143	84040	557901	55648983
Discomfort	47.31	9.83	89	85094	141672	56065212
Palpitations	47.29	9.83	285	84898	99387	56107497
Musculoskeletal stiffness	46.11	9.83	105	85078	155902	56050982
Product dose omission issue	45.55	9.83	492	84691	204261	56002623
C-reactive protein increased	45.07	9.83	32	85151	78652	56128232
Acute kidney injury	44.54	9.83	200	84983	240563	55966321
Dyspnoea	43.68	9.83	1189	83994	591388	55615496
Emotional distress	41.69	9.83	119	85064	29644	56177240
Bronchitis	39.96	9.83	299	84884	112012	56094872
Mobility decreased	38.75	9.83	56	85127	98935	56107949
Sinusitis	38.63	9.83	463	84720	197118	56009766
Seasonal allergy	38.45	9.83	82	85101	17026	56189858
Impaired healing	38.23	9.83	45	85138	86796	56120088
Depression	36.50	9.83	425	84758	179692	56027192
Tinnitus	36.29	9.83	114	85069	29928	56176956
Periorbital oedema	35.86	9.83	42	85141	5212	56201672
Gallbladder disorder	35.46	9.83	80	85103	17254	56189630
C-reactive protein abnormal	34.20	9.83	7	85176	36802	56170082
Abdominal discomfort	33.88	9.83	263	84920	277011	55929873
Knee arthroplasty	32.68	9.83	13	85170	44246	56162638
Blister	32.39	9.83	73	85110	108814	56098070
Rhinitis allergic	32.24	9.83	51	85132	8423	56198461
Pancytopenia	31.11	9.83	54	85129	88661	56118223
Anaphylactic reaction	30.77	9.83	173	85010	58822	56148062
Nasal congestion	30.53	9.83	167	85016	56203	56150681
Therapeutic product effect incomplete	30.01	9.83	73	85110	105958	56100926
Ill-defined disorder	29.65	9.83	36	85147	68507	56138377
Infection	29.33	9.83	180	85003	200026	56006858
Diarrhoea	28.58	9.83	1209	83974	637298	55569586
Sinus disorder	28.17	9.83	82	85101	20652	56186232
Throat irritation	27.41	9.83	110	85073	32573	56174311
Allergy test positive	27.17	9.83	13	85170	397	56206487
Chest pain	26.93	9.83	420	84763	189377	56017507
Liver injury	26.74	9.83	15	85168	41833	56165051
Product use issue	26.35	9.83	169	85014	185872	56021012
Head discomfort	26.32	9.83	57	85126	11957	56194927
Upper respiratory tract infection	26.03	9.83	191	84992	71097	56135787
Mast cell activation syndrome	25.98	9.83	15	85168	677	56206207
Photosensitivity reaction	25.89	9.83	61	85122	13532	56193352
Multiple organ dysfunction syndrome	25.84	9.83	25	85158	52745	56154139
Gastrointestinal disorder	24.36	9.83	88	85095	112614	56094270
Tinea pedis	23.57	9.83	18	85165	1302	56205582
Multiple allergies	23.23	9.83	50	85133	10446	56196438
Acquired haemophilia	22.91	9.83	16	85167	1008	56205876
Rhabdomyolysis	22.67	9.83	17	85166	40641	56166243
Feeling hot	22.09	9.83	123	85060	41664	56165220
Infusion related reaction	21.99	9.83	206	84977	208725	55998159
Biliary dyskinesia	21.82	9.83	23	85160	2540	56204344
Essential hypertension	21.79	9.83	31	85152	4662	56202222
Dry mouth	21.74	9.83	169	85014	64036	56142848
Throat tightness	21.74	9.83	79	85104	22328	56184556
Hypersomnia	21.60	9.83	64	85119	16277	56190607
Oropharyngeal pain	21.30	9.83	207	84976	83581	56123303
Cystitis noninfective	21.28	9.83	15	85168	959	56205925
Cystoid macular oedema	21.12	9.83	18	85165	1523	56205361
Deep vein thrombosis	20.97	9.83	193	84990	76784	56130100
Paraesthesia	20.92	9.83	295	84888	130219	56076665
Hepatocellular injury	20.91	9.83	7	85176	26507	56180377
Nervousness	20.72	9.83	93	85090	28922	56177962
Vision blurred	20.64	9.83	204	84979	82739	56124145
Malignant neoplasm progression	20.55	9.83	51	85132	73536	56133348
Hip arthroplasty	20.46	9.83	17	85166	38606	56168278
Expired product administered	20.33	9.83	33	85150	5569	56201315
Eye pruritus	20.09	9.83	57	85126	14149	56192735
Incorrect dose administered	19.88	9.83	142	85041	52405	56154479
Abdominal distension	19.84	9.83	192	84991	77434	56129450
Dry skin	19.41	9.83	130	85053	46979	56159905
Intentional product use issue	18.93	9.83	82	85101	99651	56107233
Urinary tract infection	18.88	9.83	487	84696	240026	55966858
Eye swelling	18.77	9.83	73	85110	21303	56185581
Bone pain	18.63	9.83	135	85048	50050	56156834
Suicidal ideation	18.46	9.83	150	85033	57592	56149292
Cholelithiasis	18.17	9.83	112	85071	39352	56167532
Migraine	18.09	9.83	206	84977	86591	56120293
Lupus hepatitis	17.94	9.83	5	85178	29	56206855
Nausea	17.70	9.83	1363	83820	762815	55444069
Thrombocytopenia	17.66	9.83	127	85056	136097	56070787
Status asthmaticus	17.58	9.83	13	85170	896	56205988
Gallbladder injury	17.44	9.83	15	85168	1285	56205599
Arthralgia	17.43	9.83	603	84580	501066	55705818
Condition aggravated	17.24	9.83	394	84789	344504	55862380
Swollen tongue	17.20	9.83	91	85092	30233	56176651
Premature baby	17.13	9.83	4	85179	19201	56187683
Neuropathy peripheral	17.07	9.83	234	84949	102659	56104225
Abnormal dreams	16.98	9.83	42	85141	9607	56197277
Renal impairment	16.80	9.83	64	85119	80649	56126235
Upper-airway cough syndrome	16.52	9.83	41	85142	9397	56197487
Medication error	16.51	9.83	24	85159	42311	56164573
Cardiac failure	16.50	9.83	66	85117	82027	56124857
Allergic cystitis	16.49	9.83	3	85180	0	56206884
Sinus headache	16.38	9.83	28	85155	4930	56201954
Septic shock	16.34	9.83	43	85140	60792	56146092
Temperature intolerance	16.32	9.83	37	85146	8003	56198881
Red blood cell sedimentation rate increased	16.09	9.83	19	85164	36604	56170280
Hyperkalaemia	16.03	9.83	33	85150	50832	56156052
Erythema	16.03	9.83	328	84855	155611	56051273
Pulmonary fibrosis	15.89	9.83	13	85170	29745	56177139
Psoriatic arthropathy	15.85	9.83	58	85125	73950	56132934
Sopor	15.68	9.83	6	85177	20916	56185968
Basophil count decreased	15.57	9.83	6	85177	106	56206778
Pulmonary embolism	15.54	9.83	238	84945	106886	56099998
Illness	15.30	9.83	97	85086	34414	56172470
Drug resistance	15.22	9.83	6	85177	20536	56186348
Hepatotoxicity	14.97	9.83	15	85168	31138	56175746
Pre-existing condition improved	14.97	9.83	34	85149	7364	56199520
Nasal disorder	14.96	9.83	19	85164	2563	56204321
Back pain	14.93	9.83	467	84716	236703	55970181
Posterior reversible encephalopathy syndrome	14.90	9.83	3	85180	15957	56190927
Inflammation	14.87	9.83	54	85129	69017	56137867
White blood cell count decreased	14.64	9.83	270	84913	125720	56081164
Reversible cerebral vasoconstriction syndrome	14.58	9.83	18	85165	2359	56204525
Dysgeusia	14.58	9.83	109	85074	40806	56166078
Hyponatraemia	14.34	9.83	93	85090	102046	56104838
Dyspepsia	14.32	9.83	191	84992	83280	56123604
Emotional disorder	14.25	9.83	46	85137	12249	56194635
Loss of personal independence in daily activities	14.19	9.83	69	85114	81300	56125584
Chills	14.14	9.83	226	84957	102378	56104506
Crying	14.04	9.83	67	85116	21373	56185511
Neurological examination abnormal	13.99	9.83	7	85176	236	56206648
Osteonecrosis of jaw	13.92	9.83	18	85165	33340	56173544
Hot flush	13.67	9.83	119	85064	46607	56160277
Completed suicide	13.62	9.83	133	85050	133700	56073184
Depressed level of consciousness	13.60	9.83	42	85141	56391	56150493
Chronic spontaneous urticaria	13.49	9.83	12	85171	1075	56205809
Drug interaction	13.37	9.83	230	84953	209525	55997359
Injury	13.36	9.83	144	85039	59707	56147177
Bronchospasm	13.35	9.83	53	85130	15616	56191268
Reflux gastritis	13.28	9.83	12	85171	1098	56205786
Agranulocytosis	13.25	9.83	9	85174	22650	56184234
Victim of chemical submission	13.04	9.83	8	85175	404	56206480
Impaired quality of life	12.97	9.83	35	85148	8439	56198445
Red blood cell sedimentation rate abnormal	12.96	9.83	6	85177	18667	56188217
Anger	12.93	9.83	43	85140	11629	56195255
Xanthogranuloma	12.88	9.83	3	85180	7	56206877
Cataract subcapsular	12.87	9.83	9	85174	568	56206316
Snoring	12.87	9.83	21	85162	3560	56203324
Initial insomnia	12.83	9.83	27	85156	5552	56201332
Rash	12.83	9.83	888	84295	492159	55714725
Oesophageal adenocarcinoma recurrent	12.82	9.83	4	85179	36	56206848
Palmar erythema	12.80	9.83	14	85169	1613	56205271
Burning sensation	12.71	9.83	121	85062	48575	56158309
Mitral valve prolapse	12.41	9.83	16	85167	2190	56204694
Autoimmune hepatitis	12.41	9.83	33	85150	7888	56198996
Panic disorder	12.38	9.83	17	85166	2474	56204410
Cytomegalovirus infection	12.21	9.83	7	85176	19289	56187595
Cluster headache	12.20	9.83	9	85174	618	56206266
Fracture	12.19	9.83	6	85177	18012	56188872
Wheezing	12.18	9.83	170	85013	74856	56132028
Overdose	12.15	9.83	102	85081	105728	56101156
Somnambulism	12.13	9.83	25	85158	5067	56201817
Infusion site erythema	12.11	9.83	37	85146	9569	56197315
Hepatic failure	12.09	9.83	20	85163	33466	56173418
Heart rate increased	12.07	9.83	185	84998	83088	56123796
Acute hepatic failure	12.02	9.83	5	85178	16573	56190311
Sleep apnoea syndrome	12.02	9.83	74	85109	25987	56180897
Lactic acidosis	11.95	9.83	22	85161	35324	56171560
Premature delivery	11.93	9.83	14	85169	27046	56179838
Sinus congestion	11.68	9.83	51	85132	15673	56191211
Skin burning sensation	11.65	9.83	40	85143	10991	56195893
Flushing	11.45	9.83	159	85024	69941	56136943
Fatigue	11.44	9.83	1361	83822	787191	55419693
Laryngeal oedema	11.41	9.83	25	85158	5285	56201599
Acute sinusitis	11.41	9.83	20	85163	3593	56203291
Biliary sepsis	11.36	9.83	10	85173	884	56206000
Joint range of motion decreased	11.31	9.83	13	85170	25352	56181532
Presbyoesophagus	11.30	9.83	3	85180	14	56206870
Blood pressure fluctuation	11.24	9.83	28	85155	40332	56166552
Circulatory collapse	11.21	9.83	9	85174	20794	56186090
Full blood count decreased	11.21	9.83	67	85116	23282	56183602
Disturbance in attention	11.21	9.83	86	85097	32454	56174430
Live birth	11.19	9.83	8	85175	19597	56187287
Bezoar	11.16	9.83	12	85171	1356	56205528
Cerebral disorder	11.12	9.83	21	85162	3995	56202889
Ear congestion	11.04	9.83	15	85168	2160	56204724
Atopy	11.03	9.83	6	85177	241	56206643
Constipation	11.00	9.83	391	84792	201552	56005332
Product quality issue	11.00	9.83	84	85099	31652	56175232
Pneumonia	10.90	9.83	735	84448	406363	55800521
Irritable bowel syndrome	10.84	9.83	60	85123	68398	56138486
Burns first degree	10.82	9.83	3	85180	17	56206867
Death	10.79	9.83	415	84768	341011	55865873
Broad ligament tear	10.68	9.83	3	85180	18	56206866
Hypoaesthesia	10.65	9.83	285	84898	141206	56065678
Myxoedema coma	10.65	9.83	7	85176	399	56206485
Ear discomfort	10.55	9.83	29	85154	7066	56199818
Torsade de pointes	10.53	9.83	42	85141	12398	56194486
Frustration tolerance decreased	10.50	9.83	27	85156	6326	56200558
Post-traumatic stress disorder	10.48	9.83	22	85161	4516	56202368
Cyclic vomiting syndrome	10.47	9.83	4	85179	69	56206815
Patellofemoral pain syndrome	10.46	9.83	8	85175	580	56206304
Infusion site swelling	10.45	9.83	31	85152	7890	56198994
Multiple lentigines syndrome	10.44	9.83	5	85178	153	56206731
Ear swelling	10.36	9.83	11	85172	1225	56205659
Status epilepticus	10.30	9.83	5	85178	15136	56191748
Cerumen impaction	10.20	9.83	10	85173	1014	56205870
Myelosuppression	10.12	9.83	7	85176	17448	56189436
Incorrect dosage administered	10.09	9.83	13	85170	1778	56205106
Paraesthesia oral	10.08	9.83	46	85137	14403	56192481
Hyperlipidaemia	10.04	9.83	54	85129	18055	56188829
Drug level increased	9.93	9.83	10	85173	20715	56186169
Defaecation urgency	9.85	9.83	18	85165	3341	56203543

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Accidental exposure to product by child	294.52	10.66	99	39946	1403	31655896
Extra dose administered	219.17	10.66	100	39945	3300	31653999
Failure of child resistant product closure	77.42	10.66	16	40029	21	31657278
Drug abuse	74.58	10.66	11	40034	87747	31569552
Urticaria	69.36	10.66	194	39851	57323	31599976
General physical health deterioration	60.54	10.66	34	40011	113401	31543898
Rash	55.79	10.66	440	39605	201046	31456253
Pruritus	53.09	10.66	304	39741	124863	31532436
Infective pulmonary exacerbation of cystic fibrosis	50.48	10.66	51	39994	6433	31650866
Off label use	44.70	10.66	257	39788	347017	31310282
Fatigue	43.06	10.66	627	39418	334579	31322720
Drug interaction	41.15	10.66	131	39914	208412	31448887
Sinusitis	38.67	10.66	118	39927	36578	31620721
Toxicity to various agents	37.94	10.66	111	39934	181376	31475923
Completed suicide	35.41	10.66	38	40007	91476	31565823
Asthma	33.36	10.66	124	39921	42487	31614812
Drug ineffective	31.91	10.66	333	39712	395240	31262059
Acute kidney injury	30.79	10.66	217	39828	279497	31377802
Rheumatoid arthritis	29.04	10.66	12	40033	47797	31609502
Cough	28.67	10.66	278	39767	134536	31522763
Throat irritation	28.50	10.66	46	39999	9268	31648031
Sinus disorder	27.85	10.66	37	40008	6258	31651041
Swelling face	27.60	10.66	74	39971	21316	31635983
Treatment failure	25.16	10.66	10	40035	40782	31616517
Chronic spontaneous urticaria	24.43	10.66	9	40036	169	31657130
Glossodynia	23.18	10.66	25	40020	3400	31653899
Pharyngeal dystonia	23.03	10.66	7	40038	70	31657229
Lacrimation increased	22.95	10.66	37	40008	7445	31649854
Infusion related reaction	22.52	10.66	120	39925	47935	31609364
Eye pruritus	21.32	10.66	29	40016	5016	31652283
Spasmodic dysphonia	20.93	10.66	8	40037	167	31657132
Gastrointestinal mucosal necrosis	20.76	10.66	8	40037	171	31657128
Seasonal allergy	20.47	10.66	30	40015	5558	31651741
Bronchitis	20.46	10.66	100	39945	38617	31618682
Oral pruritus	20.42	10.66	9	40036	273	31657026
Expired product administered	20.12	10.66	22	40023	3039	31654260
Drug resistance	19.77	10.66	3	40042	23450	31633849
CADASIL	19.14	10.66	6	40039	67	31657232
Magnetic resonance imaging spinal abnormal	18.83	10.66	6	40039	71	31657228
Renal impairment	18.60	10.66	52	39993	86297	31571002
Conduction disorder	18.58	10.66	17	40028	1897	31655402
Visual evoked potentials abnormal	18.46	10.66	6	40039	76	31657223
Dizziness	17.93	10.66	352	39693	198795	31458504
Interstitial lung disease	17.26	10.66	32	40013	61371	31595928
Muscle spasms	17.10	10.66	146	39899	68172	31589127
Lip swelling	17.09	10.66	46	39999	13277	31644022
Central nervous system inflammation	16.89	10.66	6	40039	101	31657198
Hyperkalaemia	16.83	10.66	35	40010	64316	31592983
Blood pH decreased	16.73	10.66	17	40028	2158	31655141
Nasal congestion	16.52	10.66	60	39985	20321	31636978
PO2 increased	16.48	10.66	10	40035	595	31656704
Chills	16.28	10.66	154	39891	73996	31583303
Feeling abnormal	15.98	10.66	125	39920	56877	31600422
Angioedema	15.78	10.66	84	39961	33534	31623765
Tunnel vision	15.71	10.66	9	40036	481	31656818
Rhabdomyolysis	15.46	10.66	36	40009	63545	31593754
Metamorphopsia	15.34	10.66	9	40036	503	31656796
Ejaculation delayed	14.95	10.66	7	40038	245	31657054
Heart rate increased	14.94	10.66	96	39949	41014	31616285
Vision blurred	14.69	10.66	97	39948	41818	31615481
Leukopenia	14.66	10.66	32	40013	57796	31599503
Tension headache	14.61	10.66	13	40032	1398	31655901
Chest pain	14.60	10.66	218	39827	116739	31540560
Rhinitis allergic	14.55	10.66	18	40027	2836	31654463
Saccadic eye movement	14.55	10.66	6	40039	154	31657145
Suicidal ideation	14.47	10.66	87	39958	36319	31620980
Wheezing	14.30	10.66	86	39959	35900	31621399
Burning sensation	14.17	10.66	50	39995	16697	31640602
C-reactive protein increased	13.99	10.66	25	40020	48625	31608674
Forced expiratory volume decreased	13.95	10.66	18	40027	2959	31654340
Anxiety	13.94	10.66	176	39869	90857	31566442
Sneezing	13.88	10.66	23	40022	4736	31652563
Acute respiratory distress syndrome	13.59	10.66	7	40038	24533	31632766
Insomnia	13.54	10.66	181	39864	94655	31562644
Cerebral microangiopathy	13.52	10.66	6	40039	185	31657114
Upper respiratory tract infection	13.46	10.66	73	39972	29349	31627950
Muscle tightness	13.35	10.66	22	40023	4507	31652792
Pneumonitis	13.32	10.66	75	39970	30577	31626722
Double stranded DNA antibody positive	13.17	10.66	6	40039	197	31657102
Intercepted medication error	13.05	10.66	8	40037	485	31656814
Oropharyngeal pain	13.00	10.66	76	39969	31407	31625892
Pneumonia	12.96	10.66	532	39513	334780	31322519
Gastrooesophageal reflux disease	12.86	10.66	80	39965	33791	31623508
Hyponatraemia	12.74	10.66	49	39996	73750	31583549
Foetal exposure during pregnancy	12.68	10.66	20	40025	40856	31616443
Lactic acidosis	12.63	10.66	13	40032	31924	31625375
Mucosal inflammation	12.54	10.66	15	40030	34412	31622887
Renal failure	12.41	10.66	98	39947	123232	31534067
Skin warm	12.35	10.66	14	40031	2012	31655287
Cytomegalovirus infection	12.33	10.66	8	40037	24699	31632600
Testicular cyst	12.28	10.66	4	40041	51	31657248
Sleep apnoea syndrome	11.99	10.66	51	39994	18574	31638725
Contraindicated product administered	11.94	10.66	5	40040	19767	31637532
Rhinorrhoea	11.84	10.66	59	39986	22953	31634346
Upper-airway cough syndrome	11.76	10.66	17	40028	3110	31654189
Migraine	11.71	10.66	42	40003	14138	31643161
Headache	11.63	10.66	309	39736	183343	31473956
Cardiogenic shock	11.53	10.66	7	40038	22401	31634898
Depression	11.22	10.66	169	39876	90646	31566653
Oral viral infection	11.21	10.66	3	40042	18	31657281
Crying	11.20	10.66	23	40022	5574	31651725
Convulsions local	11.07	10.66	3	40042	19	31657280
Spinal osteoarthritis	11.05	10.66	26	40019	6909	31650390
Eosinophilia	10.98	10.66	8	40037	23245	31634054
Physical examination abnormal	10.97	10.66	6	40039	293	31657006
Drug level increased	10.83	10.66	6	40039	20180	31637119
Thrombocytopenia	10.70	10.66	122	39923	142625	31514674
Rash pruritic	10.68	10.66	59	39986	23879	31633420
Blood cholesterol increased	10.68	10.66	46	39999	16847	31640452
Agitation	10.66	10.66	110	39935	54059	31603240

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Extra dose administered	531.37	9.76	240	97926	7037	70823241
Accidental exposure to product by child	457.63	9.76	165	98001	2641	70827637
Failure of child resistant product closure	192.34	9.76	39	98127	36	70830242
Urticaria	177.04	9.76	562	97604	162487	70667791
Rheumatoid arthritis	159.23	9.76	104	98062	291701	70538577
Drug ineffective	138.74	9.76	751	97415	939001	69891277
Gastrooesophageal reflux disease	138.46	9.76	354	97812	90485	70739793
Drug abuse	130.79	9.76	23	98143	147233	70683045
Off label use	127.32	9.76	563	97603	742497	70087781
Synovitis	119.65	9.76	18	98148	129210	70701068
Contraindicated product administered	117.44	9.76	22	98144	134590	70695688
General physical health deterioration	115.86	9.76	94	98072	235937	70594341
Pruritus	108.12	9.76	833	97333	344727	70485551
Infective pulmonary exacerbation of cystic fibrosis	100.48	9.76	103	98063	12055	70818223
Treatment failure	100.29	9.76	37	98129	144105	70686173
Toxicity to various agents	96.57	9.76	244	97922	381928	70448350
Drug intolerance	95.31	9.76	103	98063	225584	70604694
Swelling face	94.00	9.76	244	97922	62920	70767358
Hand deformity	87.47	9.76	9	98157	86473	70743805
Somnolence	78.99	9.76	540	97626	215066	70615212
Joint swelling	77.70	9.76	145	98021	253066	70577212
Acute kidney injury	77.26	9.76	366	97800	474258	70356020
Asthma	75.95	9.76	350	97816	120443	70709835
Dizziness	70.21	9.76	964	97202	463177	70367101
Therapeutic product effect decreased	70.08	9.76	57	98109	142961	70687317
Pneumonia aspiration	64.15	9.76	211	97955	62078	70768200
Lip swelling	64.01	9.76	144	98022	33910	70796368
Pericarditis	63.71	9.76	19	98147	84686	70745592
Systemic lupus erythematosus	58.72	9.76	34	98132	101868	70728410
C-reactive protein increased	58.04	9.76	41	98125	110476	70719802
Wound	56.81	9.76	33	98133	98699	70731579
Angioedema	56.80	9.76	212	97954	66398	70763880
Arthropathy	56.38	9.76	75	98091	149982	70680296
Butterfly rash	56.27	9.76	31	98135	1399	70828879
Glossodynia	52.54	9.76	27	98139	86460	70743818
Drug interaction	52.07	9.76	312	97854	381129	70449149
Headache	50.48	9.76	1103	97063	579302	70250976
Cholecystitis chronic	49.53	9.76	63	98103	9313	70820965
Muscle spasms	49.53	9.76	374	97792	153672	70676606
Rash	49.52	9.76	986	97180	509576	70320702
Feeling abnormal	48.88	9.76	351	97815	141968	70688310
Helicobacter infection	48.73	9.76	9	98157	55647	70774631
Cough	47.97	9.76	673	97493	324704	70505574
Throat irritation	47.09	9.76	131	98035	35173	70795105
Insomnia	45.84	9.76	482	97684	217324	70612954
Emotional distress	45.72	9.76	134	98032	37054	70793224
Anxiety	45.63	9.76	486	97680	219844	70610434
Dyspnoea	44.97	9.76	1388	96778	768672	70061606
Fatigue	44.55	9.76	1472	96694	822847	70007431
Palpitations	43.89	9.76	283	97883	110470	70719808
Chest discomfort	42.84	9.76	307	97859	124074	70706204
Chest pain	41.68	9.76	531	97635	250729	70579549
Completed suicide	41.20	9.76	168	97998	226967	70603311
Expired product administered	40.22	9.76	47	98119	6366	70823912
Nasal congestion	39.57	9.76	188	97978	65484	70764794
Renal impairment	39.38	9.76	88	98078	143849	70686429
C-reactive protein abnormal	39.04	9.76	4	98162	38575	70791703
Product dose omission issue	38.83	9.76	466	97700	217002	70613276
Sinusitis	38.25	9.76	380	97786	168815	70661463
Rhabdomyolysis	36.85	9.76	47	98119	95713	70734565
Rhinitis allergic	36.34	9.76	54	98112	9241	70821037
Bronchitis	36.19	9.76	282	97884	116961	70713317
Dermatitis atopic	36.18	9.76	53	98113	8954	70821324
Eye pruritus	35.80	9.76	69	98097	14578	70815700
Tinnitus	34.99	9.76	120	98046	36056	70794222
Pancytopenia	34.68	9.76	101	98065	151006	70679272
Drug resistance	33.81	9.76	6	98160	38184	70792094
Vision blurred	33.61	9.76	236	97930	94748	70735530
Sleep disorder due to general medical condition, insomnia type	33.01	9.76	5	98161	35727	70794551
Hyperkalaemia	32.69	9.76	61	98105	106530	70723748
Maternal exposure during pregnancy	31.97	9.76	70	98096	115275	70715003
Thrombocytopenia	30.81	9.76	199	97967	238911	70591367
Gallbladder disorder	30.10	9.76	72	98094	17640	70812638
Folliculitis	29.47	9.76	11	98155	42559	70787719
Oropharyngeal pain	28.81	9.76	230	97936	96080	70734198
Hepatocellular injury	28.57	9.76	14	98152	46077	70784201
Hepatic enzyme increased	27.91	9.76	117	98049	156873	70673405
Chronic spontaneous urticaria	27.82	9.76	18	98148	1093	70829185
Multiple organ dysfunction syndrome	27.55	9.76	69	98097	108446	70721832
Sopor	27.49	9.76	5	98161	31262	70799016
Upper respiratory tract infection	27.48	9.76	196	97970	79078	70751200
Allergy test positive	27.23	9.76	13	98153	433	70829845
Coma	26.75	9.76	218	97948	91626	70738652
Burning sensation	26.69	9.76	144	98022	52726	70777552
Head discomfort	26.66	9.76	57	98109	12966	70817312
Cytomegalovirus infection	26.33	9.76	11	98155	39747	70790531
Lower respiratory tract infection	26.26	9.76	74	98092	111839	70718439
Therapeutic product effect incomplete	26.16	9.76	82	98084	119800	70710478
Chills	25.71	9.76	310	97856	144476	70685802
Infection	25.36	9.76	179	97987	210606	70619672
Lactic acidosis	24.92	9.76	32	98134	64992	70765286
Swollen tongue	24.50	9.76	109	98057	36937	70793341
Incorrect dose administered	24.32	9.76	167	97999	66552	70763726
Mobility decreased	24.25	9.76	68	98098	102931	70727347
Status asthmaticus	24.24	9.76	16	98150	1005	70829273
Photosensitivity reaction	24.07	9.76	70	98096	19270	70811008
Sinus disorder	23.96	9.76	69	98097	18890	70811388
Migraine	23.54	9.76	176	97990	72062	70758216
Cardiac failure	23.09	9.76	111	98055	143430	70686848
Renal failure	23.02	9.76	160	98006	188910	70641368
Intentional product use issue	22.96	9.76	87	98079	120055	70710223
Depression	22.94	9.76	395	97771	198579	70631699
Interstitial lung disease	22.57	9.76	72	98094	104613	70725665
Leukopenia	22.48	9.76	74	98092	106486	70723792
Injury	22.43	9.76	161	98005	65084	70765194
Deep vein thrombosis	22.06	9.76	243	97923	110799	70719479
Seasonal allergy	22.04	9.76	54	98112	13430	70816848
Wheezing	21.99	9.76	213	97953	93957	70736321
Periorbital oedema	21.98	9.76	39	98127	7736	70822542
Musculoskeletal stiffness	21.65	9.76	118	98048	147642	70682636
Septic shock	21.64	9.76	81	98085	112177	70718101
Throat tightness	21.62	9.76	80	98086	24942	70805336
Malignant neoplasm progression	21.46	9.76	91	98075	121648	70708630
Anaphylactic reaction	21.31	9.76	177	97989	74797	70755481
Drug level increased	21.24	9.76	12	98154	36457	70793821
Acute respiratory distress syndrome	20.75	9.76	16	98150	41238	70789040
Red blood cell sedimentation rate increased	20.73	9.76	14	98152	38628	70791650
Oral pruritus	20.61	9.76	19	98147	1952	70828326
Hepatic failure	20.43	9.76	30	98136	57595	70772683
Knee arthroplasty	20.40	9.76	11	98155	34290	70795988
Discomfort	20.37	9.76	76	98090	105360	70724918
Gallbladder injury	20.22	9.76	15	98151	1137	70829141
Crying	20.22	9.76	70	98096	21129	70809149
Circulatory collapse	20.20	9.76	12	98154	35462	70794816
Feeling hot	19.66	9.76	125	98041	48545	70781733
Overdose	19.52	9.76	146	98020	169599	70660679
Product quality issue	19.52	9.76	89	98077	30472	70799806
Lacrimation increased	19.23	9.76	66	98100	19833	70810445
Dry skin	19.21	9.76	138	98028	55793	70774485
Back pain	19.12	9.76	501	97665	270651	70559627
Impaired healing	19.11	9.76	47	98119	74327	70755951
Psoriatic arthropathy	19.04	9.76	38	98128	64733	70765545
Bone marrow failure	18.91	9.76	24	98142	48986	70781292
Gastrointestinal mucosal necrosis	18.70	9.76	8	98158	205	70830073
Cystitis noninfective	18.70	9.76	15	98151	1276	70829002
Nervousness	18.68	9.76	89	98077	31031	70799247
Agranulocytosis	18.58	9.76	17	98149	40281	70789997
Urinary tract infection	17.93	9.76	461	97705	248308	70581970
Bone pain	17.81	9.76	126	98040	50696	70779582
Hypotension	17.78	9.76	425	97741	403956	70426322
Acquired haemophilia	17.69	9.76	17	98149	1840	70828438
Incorrect dosage administered	17.68	9.76	19	98147	2348	70827930
Biliary dyskinesia	17.47	9.76	19	98147	2380	70827898
Sinus headache	17.33	9.76	26	98140	4487	70825791
Hyponatraemia	17.33	9.76	140	98026	159947	70670331
Upper-airway cough syndrome	17.01	9.76	40	98126	9691	70820587
Heart rate increased	17.01	9.76	223	97943	105925	70724353
Hypersomnia	16.80	9.76	65	98101	20699	70809579
Paraesthesia	16.80	9.76	289	97877	145248	70685030
Allergic cystitis	16.75	9.76	3	98163	0	70830278
Transient ischaemic attack	16.74	9.76	115	98051	45829	70784449
Nausea	16.71	9.76	1382	96784	850706	69979572
Cerebral haemorrhage	16.36	9.76	31	98135	53833	70776445
Erythema	16.23	9.76	376	97790	199187	70631091
Myelosuppression	16.06	9.76	11	98155	30134	70800144
Eye swelling	16.01	9.76	70	98096	23544	70806734
Osteonecrosis of jaw	15.90	9.76	20	98146	40982	70789296
Status epilepticus	15.90	9.76	7	98159	24519	70805759
Transplant rejection	15.77	9.76	3	98163	18168	70812110
Emotional disorder	15.63	9.76	47	98119	13179	70817099
Hepatotoxicity	15.50	9.76	23	98143	43963	70786315
Blood pressure fluctuation	15.39	9.76	37	98129	58975	70771303
Thrombotic microangiopathy	15.38	9.76	3	98163	17845	70812433
Pulmonary fibrosis	15.21	9.76	15	98151	34295	70795983
Cystoid macular oedema	15.16	9.76	16	98150	1936	70828342
Red blood cell sedimentation rate abnormal	15.12	9.76	4	98162	19299	70810979
Eczema	15.06	9.76	89	98077	33692	70796586
Flushing	15.04	9.76	177	97989	81995	70748283
Altered state of consciousness	15.02	9.76	20	98146	40002	70790276
Pneumonia	14.87	9.76	986	97180	595246	70235032
Cardiogenic shock	14.83	9.76	17	98149	36290	70793988
Initial insomnia	14.54	9.76	29	98137	6280	70823998
Swelling	14.51	9.76	179	97987	188360	70641918
Alopecia	14.33	9.76	191	97975	198299	70631979
Condition aggravated	14.29	9.76	467	97699	427168	70403110
Posterior reversible encephalopathy syndrome	14.25	9.76	8	98158	24394	70805884
Hyperlipidaemia	14.14	9.76	68	98098	23795	70806483
Polyneuropathy	14.06	9.76	6	98160	21409	70808869
Dry mouth	13.90	9.76	154	98012	70303	70759975
Therapy non-responder	13.86	9.76	57	98109	76858	70753420
Carotid artery disease	13.63	9.76	16	98150	2177	70828101
Administration site inflammation	13.47	9.76	3	98163	6	70830272
Victim of chemical submission	13.42	9.76	8	98158	420	70829858
Syncope	13.41	9.76	312	97854	165397	70664881
Autoimmune hepatitis	13.38	9.76	39	98127	10747	70819531
Burns first degree	13.38	9.76	4	98162	34	70830244
Full blood count decreased	13.35	9.76	67	98099	23851	70806427
Panic disorder	13.20	9.76	18	98148	2846	70827432
Oesophageal adenocarcinoma recurrent	13.18	9.76	4	98162	36	70830242
Heart rate decreased	13.12	9.76	43	98123	61972	70768306
Pulmonary embolism	13.09	9.76	295	97871	155572	70674706
Illness	13.06	9.76	82	98084	31709	70798569
Face oedema	13.05	9.76	70	98096	25569	70804709
Mast cell activation syndrome	12.89	9.76	9	98157	620	70829658
Skin exfoliation	12.87	9.76	113	98053	48513	70781765
Bronchial hyperreactivity	12.86	9.76	17	98149	2609	70827669
Multiple lentigines syndrome	12.73	9.76	6	98160	194	70830084
Patellofemoral pain syndrome	12.71	9.76	8	98158	463	70829815
Palmar erythema	12.64	9.76	14	98152	1789	70828489
Visual impairment	12.61	9.76	168	97998	80082	70750196
Hypoaesthesia	12.60	9.76	290	97876	153449	70676829
Reversible cerebral vasoconstriction syndrome	12.57	9.76	17	98149	2668	70827610
Breast pain	12.56	9.76	30	98136	7341	70822937
Exposure to toxic agent	12.55	9.76	27	98139	6167	70824111
Gastrointestinal disorder	12.44	9.76	90	98076	105337	70724941
Chronic obstructive pulmonary disease	12.39	9.76	163	98003	77478	70752800
Pneumocystis jirovecii pneumonia	12.38	9.76	14	98152	30068	70800210
Suicidal ideation	12.34	9.76	149	98017	69447	70760831
Sinus congestion	12.16	9.76	52	98114	17321	70812957
Pharyngeal dystonia	12.14	9.76	4	98162	48	70830230
Rash pruritic	12.12	9.76	137	98029	62854	70767424
Haemophagocytic lymphohistiocytosis	12.09	9.76	6	98160	19606	70810672
Conduction disorder	12.02	9.76	18	98148	3100	70827178
Tinea pedis	11.99	9.76	15	98151	2181	70828097
Melaena	11.97	9.76	39	98127	56316	70773962
Neuroleptic malignant syndrome	11.96	9.76	11	98155	25996	70804282
Neurological examination abnormal	11.90	9.76	8	98158	518	70829760
Coronary artery disease	11.87	9.76	136	98030	62600	70767678
Basophil count decreased	11.86	9.76	6	98160	227	70830051
Mitral valve prolapse	11.79	9.76	14	98152	1929	70828349
Medication error	11.67	9.76	40	98126	56872	70773406
Allergy to animal	11.66	9.76	11	98155	1164	70829114
Intervertebral disc degeneration	11.64	9.76	44	98122	13856	70816422
Laryngeal pain	11.64	9.76	25	98141	5703	70824575
Hepatic cytolysis	11.64	9.76	6	98160	19186	70811092
Depressed level of consciousness	11.64	9.76	72	98094	87359	70742919
Lethargy	11.60	9.76	157	98009	75093	70755185
Non-cardiac chest pain	11.58	9.76	33	98133	8982	70821296
Ill-defined disorder	11.55	9.76	38	98128	54703	70775575
Cholelithiasis	11.51	9.76	108	98058	47232	70783046
Paraesthesia oral	11.46	9.76	47	98119	15370	70814908
Bronchospasm	11.45	9.76	62	98104	22730	70807548
Ventricular hypertrophy	11.44	9.76	27	98139	6557	70823721
Ear congestion	11.30	9.76	15	98151	2312	70827966
Mood altered	11.29	9.76	49	98117	16426	70813852
Rotator cuff syndrome	11.24	9.76	41	98125	12693	70817585
Respiratory failure	11.24	9.76	165	98001	168570	70661708
Essential hypertension	11.22	9.76	24	98142	5460	70824818
Skin burning sensation	11.13	9.76	38	98128	11388	70818890
Dyspepsia	11.05	9.76	179	97987	88898	70741380
Ear infection	10.97	9.76	72	98094	28264	70802014
Nephropathy toxic	10.92	9.76	6	98160	18508	70811770
Rhinorrhoea	10.87	9.76	140	98026	66231	70764047
Liver disorder	10.86	9.76	46	98120	61522	70768756
Anuria	10.70	9.76	7	98159	19646	70810632
Cerebrovascular accident	10.66	9.76	267	97899	143203	70687075
Blood pressure diastolic decreased	10.61	9.76	12	98154	25768	70804510
Dysgeusia	10.60	9.76	110	98056	49392	70780886
Neutropenia	10.54	9.76	273	97893	256883	70573395
Hip arthroplasty	10.54	9.76	14	98152	28026	70802252
Pain in extremity	10.52	9.76	555	97611	327527	70502751
Otitis media	10.48	9.76	24	98142	5715	70824563
Accident at home	10.46	9.76	5	98161	167	70830111
Blister	10.38	9.76	89	98077	100437	70729841
Infusion site swelling	10.32	9.76	25	98141	6173	70824105
Uterine cyst	10.31	9.76	6	98160	301	70829977
Temperature intolerance	10.31	9.76	31	98135	8692	70821586
Hypertensive crisis	10.30	9.76	7	98159	19255	70811023
Bacterial test positive	10.29	9.76	27	98139	7004	70823274
Loss of personal independence in daily activities	10.25	9.76	72	98094	84838	70745440
Intercepted medication error	10.25	9.76	9	98157	868	70829410
Delirium	10.16	9.76	61	98105	74553	70755725
Skin necrosis	10.02	9.76	5	98161	16286	70813992
Tuberculosis	10.01	9.76	4	98162	14844	70815434
Oral viral infection	10.00	9.76	4	98162	86	70830192
Rhinovirus infection	10.00	9.76	26	98140	6707	70823571
Death	9.98	9.76	591	97575	509470	70320808
Sinus operation	9.94	9.76	13	98153	1974	70828304
Cellulitis	9.85	9.76	192	97974	98736	70731542
Blood creatinine increased	9.82	9.76	139	98027	142862	70687416
Nasal discomfort	9.81	9.76	21	98145	4780	70825498
Aphthous ulcer	9.79	9.76	4	98162	14652	70815626
Testicular cyst	9.79	9.76	3	98163	28	70830250
Cataract subcapsular	9.78	9.76	9	98157	922	70829356

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	R06AX13	RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Other antihistamines for systemic use
CHEBI has role	CHEBI:37955	H1 receptor antagonists
CHEBI has role	CHEBI:48873	acetylcholine receptor antagonist
CHEBI has role	CHEBI:50857	anti-allergic drugs
CHEBI has role	CHEBI:176497	geroprotectors
MeSH PA	D018926	Anti-Allergic Agents
MeSH PA	D000982	Antipruritics
MeSH PA	D003879	Dermatologic Agents
MeSH PA	D018494	Histamine Agents
MeSH PA	D006633	Histamine Antagonists
MeSH PA	D006634	Histamine H1 Antagonists
MeSH PA	D039563	Histamine H1 Antagonists, Non-Sedating
MeSH PA	D018377	Neurotransmitter Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Vasomotor rhinitis	indication	8229003	DOID:4730
Allergic rhinitis	indication	61582004
Nasal discharge	indication	64531003
Nasal congestion	indication	68235000
Sneezing	indication	76067001
Common cold	indication	82272006	DOID:10459
Chronic idiopathic urticaria	indication	302162004
Seasonal allergic rhinitis	indication	367498001
Allergic conjunctivitis	indication	473460002	DOID:11204
Bone pain after neupogen	off-label use	12584003
Urticaria	off-label use	126485001
Hyperthyroidism	contraindication	34486009	DOID:7998
Hypertensive disorder	contraindication	38341003	DOID:10763
Coronary arteriosclerosis	contraindication	53741008	DOID:3393
Hepatic failure	contraindication	59927004
Diabetes mellitus	contraindication	73211009	DOID:9351
Kidney disease	contraindication	90708001	DOID:557
Impaired renal function disorder	contraindication	197663003
Disease of liver	contraindication	235856003	DOID:409
Benign prostatic hyperplasia	contraindication	266569009
Retention of urine	contraindication	267064002
Angle-closure glaucoma	contraindication	392291006	DOID:13550
Hypertensive urgency	contraindication	443482000

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.43	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Histamine H1 receptor	GPCR	P35367	HRH1_HUMAN	ANTAGONIST	Ki	6.97		WOMBAT-PK	CHEMBL
Multidrug resistance protein 1	Transporter	P08183	MDR1_HUMAN		Ki	4.94		WOMBAT-PK
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN		Ki	6.81		DRUG MATRIX
Nuclear receptor subfamily 1 group I member 2	Nuclear hormone receptor	O75469	NR1I2_HUMAN		EC50	5.52		CHEMBL
Cytochrome P450 2C19	Enzyme	P33261	CP2CJ_HUMAN		IC50	7.80		DRUG MATRIX
Potassium channel subfamily K member 9	Ion channel	Q9NPC2	KCNK9_HUMAN		IC50	4.20		CHEMBL
Bile acid receptor	Nuclear hormone receptor	Q96RI1	NR1H4_HUMAN		IC50	5.51		CHEMBL
Potassium voltage-gated channel subfamily H member 2	Ion channel	Q12809	KCNH2_HUMAN		IC50	6.77		WOMBAT-PK
Sodium-dependent neutral amino acid transporter B(0)AT2	Transporter	Q9H2J7	S6A15_HUMAN		IC50	5.40		CHEMBL
Histamine H1 receptor	GPCR		HRH1_CAVPO		Kd	7.14		CHEMBL
Histamine H1 receptor	GPCR		HRH1_RAT		Ki	6.46		CHEMBL

External reference:

ID	Source
4020716	VUID
N0000148306	NUI
D00364	KEGG_DRUG
4020716	VANDF
C0065180	UMLSCUI
CHEBI:6538	CHEBI
CHEMBL998	ChEMBL_ID
DB00455	DRUGBANK_ID
D017336	MESH_DESCRIPTOR_UI
3957	PUBCHEM_CID
7216	IUPHAR_LIGAND_ID
5864	INN_ID
7AJO3BO7QN	UNII
203576	RXNORM
191	MMSL
45829	MMSL
4994	MMSL
d03050	MMSL
003909	NDDF
015760	NDDF
108652002	SNOMEDCT_US
386884002	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
allergy relief	HUMAN OTC DRUG LABEL	1	0067-6066	TABLET	10 mg	ORAL	NDA	15 sections
allergy relief	HUMAN OTC DRUG LABEL	1	0067-6122	TABLET	10 mg	ORAL	NDA	15 sections
good sense allergy relief	HUMAN OTC DRUG LABEL	1	0113-0612	TABLET	10 mg	ORAL	ANDA	15 sections
Good Sense childrens allergy relief	HUMAN OTC DRUG LABEL	1	0113-0671	SOLUTION	5 mg	ORAL	ANDA	14 sections
good sense childrens allergy relief	HUMAN OTC DRUG LABEL	1	0113-1019	TABLET, CHEWABLE	5 mg	ORAL	ANDA	15 sections
good sense allergy relief	HUMAN OTC DRUG LABEL	1	0113-1191	TABLET, ORALLY DISINTEGRATING	10 mg	ORAL	ANDA	15 sections
good sense allergy relief	HUMAN OTC DRUG LABEL	1	0113-1612	TABLET	10 mg	ORAL	ANDA	15 sections
good sense childrens allergy relief	HUMAN OTC DRUG LABEL	1	0113-1719	SOLUTION	5 mg	ORAL	ANDA	14 sections
Allergy and Congestion Relief	HUMAN OTC DRUG LABEL	2	0113-2007	TABLET, FILM COATED, EXTENDED RELEASE	5 mg	ORAL	ANDA	14 sections
basic care childrens allergy relief	HUMAN OTC DRUG LABEL	1	0113-7500	TABLET, CHEWABLE	5 mg	ORAL	ANDA	15 sections
basic care childrens allergy relief	HUMAN OTC DRUG LABEL	1	0113-7500	TABLET, CHEWABLE	5 mg	ORAL	ANDA	15 sections
Basic Care allergy relief	HUMAN OTC DRUG LABEL	1	0113-7612	TABLET	10 mg	ORAL	ANDA	15 sections
Basic Care Childrens Allergy Relief	HUMAN OTC DRUG LABEL	1	0113-7671	SOLUTION	5 mg	ORAL	ANDA	14 sections
perrigo allergy d	HUMAN OTC DRUG LABEL	2	0113-7777	TABLET, FILM COATED, EXTENDED RELEASE	5 mg	ORAL	ANDA	15 sections
good sense allergy relief	HUMAN OTC DRUG LABEL	1	0113-9755	TABLET, ORALLY DISINTEGRATING	10 mg	ORAL	ANDA	15 sections
Childrens Loratadine	HUMAN OTC DRUG LABEL	1	0121-0849	SOLUTION	5 mg	ORAL	ANDA	16 sections
Childrens Loratadine	HUMAN OTC DRUG LABEL	1	0121-0849	SOLUTION	5 mg	ORAL	ANDA	16 sections
Loratadine	HUMAN OTC DRUG LABEL	1	0363-0522	TABLET	10 mg	ORAL	ANDA	15 sections
Loratadine	HUMAN OTC DRUG LABEL	1	0363-0527	TABLET, ORALLY DISINTEGRATING	10 mg	ORAL	ANDA	15 sections
Wal itin	HUMAN OTC DRUG LABEL	1	0363-0699	TABLET	10 mg	ORAL	ANDA	15 sections
Loratadine and Pseudoephedrine	HUMAN OTC DRUG LABEL	2	0363-0725	TABLET, FILM COATED, EXTENDED RELEASE	10 mg	ORAL	ANDA	16 sections
Loratadine	HUMAN OTC DRUG LABEL	1	0363-0752	TABLET, CHEWABLE	5 mg	ORAL	ANDA	16 sections
Wal-itin	HUMAN OTC DRUG LABEL	1	0363-0754	TABLET, CHEWABLE	5 mg	ORAL	ANDA	16 sections
Indoor Outdoor Allergy Relief	HUMAN OTC DRUG LABEL	1	0363-0858	TABLET	10 mg	ORAL	ANDA	14 sections
12 hour allergy and congestion	HUMAN OTC DRUG LABEL	2	0363-1133	TABLET, FILM COATED, EXTENDED RELEASE	5 mg	ORAL	ANDA	14 sections
allergy relief	HUMAN OTC DRUG LABEL	1	0363-1612	TABLET	10 mg	ORAL	ANDA	15 sections
allergy relief	HUMAN OTC DRUG LABEL	1	0363-1612	TABLET	10 mg	ORAL	ANDA	15 sections
WAL-ITIN	HUMAN OTC DRUG LABEL	1	0363-1686	CAPSULE, LIQUID FILLED	10 mg	ORAL	ANDA	16 sections
WAL-ITIN	HUMAN OTC DRUG LABEL	1	0363-1686	CAPSULE, LIQUID FILLED	10 mg	ORAL	ANDA	16 sections
Wal-itin Allergy Relief	HUMAN OTC DRUG LABEL	1	0363-2085	SOLUTION	5 mg	ORAL	ANDA	15 sections