Stem definition | Drug id | CAS RN |
---|---|---|
antibiotics, carbacephem derivatives | 1603 | 76470-66-1 |
Dose | Unit | Route |
---|---|---|
0.60 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 10 mg/mL | Bocci G, Oprea TI, Benet LZ |
EoM (Fraction excreted unchanged in urine) | 94 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 19.07 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 94 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 31, 1991 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 113.07 | 104.83 | 23 | 3 | 310664 | 63178332 |
None
None
None
Source | Code | Description |
---|---|---|
ATC | J01DC08 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER BETA-LACTAM ANTIBACTERIALS Second-generation cephalosporins |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
CHEBI has role | CHEBI:33281 | antibiotics |
CHEBI has role | CHEBI:36047 | antibacterial drugs |
CHEBI has role | CHEBI:50904 | alergeno |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Infection of skin AND/OR subcutaneous tissue | indication | 19824006 | |
Bronchitis | indication | 32398004 | DOID:6132 |
Pneumonia due to Streptococcus | indication | 34020007 | |
Lower respiratory tract infection | indication | 50417007 | |
Upper respiratory infection | indication | 54150009 | |
Chronic pyelonephritis | indication | 63302006 | DOID:1076 |
Acute maxillary sinusitis | indication | 68272006 | DOID:2050 |
Urinary tract infectious disease | indication | 68566005 | |
Haemophilus influenzae pneumonia | indication | 70036007 | |
Tonsillitis | indication | 90176007 | DOID:10456 |
Acute bacterial bronchitis | indication | 233598009 | |
Pneumonia | indication | 233604007 | DOID:552 |
Streptococcus pyogenes infection | indication | 302809008 | |
Infective otitis media | indication | 312218008 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 2.14 | acidic |
pKa2 | 13.72 | acidic |
pKa3 | 7.59 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Bacterial penicillin-binding protein | Enzyme | INHIBITOR | CHEMBL | CHEMBL | |||||
Penicillin-binding protein 1A | Enzyme | WOMBAT-PK |
ID | Source |
---|---|
4020247 | VUID |
N0000148145 | NUI |
D00916 | KEGG_DRUG |
4020247 | VANDF |
C0065295 | UMLSCUI |
CHEBI:281056 | CHEBI |
CHEMBL1200610 | ChEMBL_ID |
CHEMBL1013 | ChEMBL_ID |
DB00447 | DRUGBANK_ID |
C054920 | MESH_SUPPLEMENTAL_RECORD_UI |
5284585 | PUBCHEM_CID |
12247 | IUPHAR_LIGAND_ID |
3X11EVM5SU | UNII |
218074 | RXNORM |
2085 | MMSL |
4993 | MMSL |
d00105 | MMSL |
003667 | NDDF |
370362008 | SNOMEDCT_US |
96061006 | SNOMEDCT_US |
121961-22-6 | SECONDARY_CAS_RN |
None