lofepramine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
substances of the imipramine group 1592 23047-25-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • lofepramine
  • lopramine
  • lofepramine hydrochloride
  • lopramine hydrochloride
  • WHR-2908A
  • lofepramine HCl
  • lopramine HCl
A psychotropic IMIPRAMINE derivative that acts as a tricyclic antidepressant and possesses few anticholinergic properties. It is metabolized to DESIPRAMINE.
  • Molecular weight: 418.97
  • Formula: C26H27ClN2O
  • CLOGP: 7.29
  • LIPINSKI: 1
  • HAC: 3
  • HDO: 0
  • TPSA: 23.55
  • ALOGS: -5.70
  • ROTB: 7

Drug dosage:

DoseUnitRoute
0.11 g O

ADMET properties:

Approvals:

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Drug Use | Suggest Off label Use Form| |View source of the data|




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

External reference:

Pharmaceutical products:

None

lofepramine