lisinopril 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
angiotensin-converting enzyme inhibitors 1587 76547-98-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • lisinopril
  • linopril
  • nanopril
  • lisinopril hydrate
  • lisinopril dihydrate
  • anhydrous lisinopril
One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS (ACE inhibitors), orally active, that has been used in the treatment of hypertension and congestive heart failure.
  • Molecular weight: 405.50
  • Formula: C21H31N3O5
  • CLOGP: -1.82
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 4
  • TPSA: 132.96
  • ALOGS: -3.27
  • ROTB: 12
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 97 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 94 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.41 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 25 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.89 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.20 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 1 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 42 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 29, 1987 FDA MERCK

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Angioedema 1676.57 9.69 1377 229496 40076 56021118
Cardiac failure congestive 604.42 9.69 1198 229675 86522 55974672
Intestinal angioedema 596.71 9.69 183 230690 456 56060738
Myocardial infarction 535.44 9.69 1179 229694 91691 55969503
Swollen tongue 334.38 9.69 510 230363 29814 56031380
Drug ineffective 330.35 9.69 2315 228558 916674 55144520
Cerebrovascular accident 323.80 9.69 1019 229854 98251 55962943
Rheumatoid arthritis 298.53 9.69 709 230164 381895 55679299
Off label use 261.96 9.69 1283 229590 554897 55506297
Acute kidney injury 261.83 9.69 1787 229086 238976 55822218
Coronary artery disease 238.18 9.69 442 230431 30354 56030840
Maternal exposure during pregnancy 221.38 9.69 271 230602 189282 55871912
Contraindicated product administered 213.71 9.69 270 230603 186016 55875178
Lip swelling 174.96 9.69 354 230519 25918 56035276
Pyrexia 172.38 9.69 1010 229863 417763 55643431
Drug intolerance 171.52 9.69 537 230336 264281 55796913
Completed suicide 168.32 9.69 1031 229842 132802 55928392
Infusion related reaction 157.24 9.69 394 230479 208537 55852657
Systemic lupus erythematosus 152.98 9.69 318 230555 179760 55881434
Pemphigus 151.71 9.69 257 230616 156955 55904239
C-reactive protein increased 150.52 9.69 67 230806 78617 55982577
Exposure during pregnancy 145.75 9.69 208 230665 136134 55925060
Acute myocardial infarction 145.52 9.69 359 230514 30034 56031160
Synovitis 142.00 9.69 279 230594 161026 55900168
Drug hypersensitivity 137.86 9.69 1729 229144 273476 55787718
Blood glucose increased 136.81 9.69 641 230232 74510 55986684
Drug abuse 135.05 9.69 54 230819 67556 55993638
Hyperkalaemia 130.43 9.69 482 230391 50383 56010811
Hypertension 118.58 9.69 1526 229347 242752 55818442
Febrile neutropenia 109.86 9.69 164 230709 105381 55955813
Lactic acidosis 109.81 9.69 357 230516 34989 56026205
Renal failure 104.13 9.69 793 230080 109707 55951487
Lower respiratory tract infection 104.09 9.69 195 230678 114599 55946595
Dehydration 103.52 9.69 1051 229822 157774 55903420
Hand deformity 95.48 9.69 261 230612 134231 55926963
Glossodynia 94.52 9.69 315 230558 152143 55909051
Arthropathy 92.10 9.69 465 230408 199810 55861384
Neutropenia 89.26 9.69 340 230533 157827 55903367
Abortion spontaneous 87.28 9.69 35 230838 43718 56017476
Dizziness 86.42 9.69 2085 228788 374055 55687139
Diarrhoea 83.76 9.69 3304 227569 635203 55425991
Injury 82.18 9.69 472 230401 59379 56001815
Interstitial lung disease 82.05 9.69 68 230805 56995 56004199
Alopecia 80.92 9.69 791 230082 292667 55768527
Infection 80.47 9.69 486 230387 199720 55861474
Product dose omission issue 79.14 9.69 1229 229644 203524 55857670
Swelling face 75.56 9.69 440 230433 55629 56005565
Joint swelling 75.00 9.69 793 230080 289007 55772187
Treatment failure 74.74 9.69 402 230471 169990 55891204
Hypovolaemia 74.34 9.69 139 230734 9596 56051598
Labile blood pressure 72.06 9.69 58 230815 1635 56059559
Coronary arterial stent insertion 71.79 9.69 71 230802 2639 56058555
Therapeutic product effect incomplete 71.39 9.69 211 230662 105820 55955374
Pancreatitis 70.96 9.69 369 230504 44711 56016483
Premature delivery 70.13 9.69 13 230860 27047 56034147
Hypotensive transfusion reaction 68.02 9.69 19 230854 29 56061165
Chest pain 67.99 9.69 1125 229748 188672 55872522
Mental status changes 66.85 9.69 318 230555 37183 56024011
Hepatic function abnormal 66.75 9.69 29 230844 34529 56026665
Asthenia 66.16 9.69 1858 229015 341115 55720079
Coronary artery bypass 66.00 9.69 63 230810 2240 56058954
Blood pressure increased 65.38 9.69 895 229978 144281 55916913
Nausea 65.23 9.69 3790 227083 760388 55300806
Sleep disorder due to general medical condition, insomnia type 64.36 9.69 50 230823 43288 56017906
Gastrointestinal haemorrhage 63.29 9.69 530 230343 75421 55985773
Arthralgia 61.04 9.69 1579 229294 500090 55561104
Therapeutic product effect decreased 59.17 9.69 429 230444 169023 55892171
Blood pressure inadequately controlled 58.42 9.69 82 230791 4442 56056752
Wound 57.84 9.69 333 230540 138471 55922723
Chronic kidney disease 57.29 9.69 331 230542 41725 56019469
Type 2 diabetes mellitus 55.70 9.69 356 230517 46506 56014688
Hepatic enzyme increased 55.54 9.69 443 230430 170941 55890253
Product use issue 55.29 9.69 492 230381 185549 55875645
Gastrointestinal disorder 55.06 9.69 256 230617 112446 55948748
Hypotension 54.54 9.69 1379 229494 249129 55812065
Sopor 54.33 9.69 10 230863 20912 56040282
Foetal exposure during pregnancy 54.18 9.69 36 230837 33787 56027407
Abdominal discomfort 53.29 9.69 808 230065 276466 55784728
Cough 51.95 9.69 1415 229458 258546 55802648
Leukopenia 50.82 9.69 137 230736 70803 55990391
Cytomegalovirus infection 50.58 9.69 9 230864 19287 56041907
Intentional self-injury 49.83 9.69 20 230853 24972 56036222
Angina unstable 49.13 9.69 95 230778 6726 56054468
Nasopharyngitis 47.71 9.69 629 230244 220330 55840864
Hepatotoxicity 47.47 9.69 35 230838 31118 56030076
Overdose 47.31 9.69 248 230625 105582 55955612
Muscle spasms 46.87 9.69 808 230065 136563 55924631
Folliculitis 46.70 9.69 97 230776 54882 56006312
Muscle injury 45.98 9.69 91 230782 52409 56008785
Transient ischaemic attack 45.56 9.69 264 230609 33313 56027881
Agranulocytosis 45.40 9.69 18 230855 22641 56038553
Prescribed overdose 44.90 9.69 196 230677 22100 56039094
Malignant neoplasm progression 44.24 9.69 154 230719 73433 55987761
Product complaint 44.20 9.69 127 230746 11633 56049561
Renal injury 43.62 9.69 106 230767 8781 56052413
Oxygen saturation decreased 43.26 9.69 172 230701 78895 55982299
Pain 43.26 9.69 2252 228621 660932 55400262
Pericarditis 42.89 9.69 266 230607 108657 55952537
Spinal stenosis 42.13 9.69 140 230733 13874 56047320
Pregnancy 42.01 9.69 44 230829 32989 56028205
Myelosuppression 41.91 9.69 10 230863 17445 56043749
Suspected suicide 41.68 9.69 78 230795 5388 56055806
Glycosylated haemoglobin increased 41.41 9.69 120 230753 11045 56050149
Depressed level of consciousness 41.16 9.69 108 230765 56325 56004869
Stomatitis 41.13 9.69 308 230565 120502 55940692
Arterial occlusive disease 41.00 9.69 77 230796 5333 56055861
Premature baby 40.59 9.69 14 230859 19191 56042003
Atrioventricular block second degree 39.99 9.69 62 230811 3674 56057520
Pneumocystis jirovecii pneumonia 39.72 9.69 8 230865 15693 56045501
Cardiac disorder 39.71 9.69 323 230550 45564 56015630
Suicide attempt 39.71 9.69 114 230759 57722 56003472
Pancreatitis acute 39.08 9.69 205 230668 24919 56036275
Rheumatoid nodule 38.79 9.69 7 230866 14850 56046344
Arteriosclerosis 38.39 9.69 105 230768 9348 56051846
Memory impairment 37.87 9.69 531 230342 86026 55975168
Mucosal inflammation 37.66 9.69 74 230799 42736 56018458
Sedation 37.38 9.69 53 230820 34801 56026393
Swelling 37.22 9.69 726 230147 239045 55822149
Psoriasis 37.14 9.69 560 230313 92132 55969062
Ischaemic cardiomyopathy 37.05 9.69 47 230826 2307 56058887
Foetal methotrexate syndrome 36.97 9.69 14 230859 78 56061116
Tenosynovitis 36.92 9.69 4 230869 12457 56048737
Blood sodium decreased 36.66 9.69 185 230688 22149 56039045
Fall 36.46 9.69 1804 229069 355706 55705488
Cardiomyopathy 35.90 9.69 147 230726 16111 56045083
Atrial fibrillation 35.87 9.69 637 230236 108260 55952934
Thrombocytopenia 35.48 9.69 372 230501 135852 55925342
Anti-cyclic citrullinated peptide antibody positive 34.70 9.69 249 230624 98351 55962843
Product quality issue 34.62 9.69 236 230637 31500 56029694
Blood pressure fluctuation 34.45 9.69 71 230802 40289 56020905
Red blood cell sedimentation rate increased 34.25 9.69 61 230812 36562 56024632
Somatic delusion 34.16 9.69 24 230849 548 56060646
Status epilepticus 33.84 9.69 10 230863 15131 56046063
Gangrene 33.77 9.69 72 230801 5468 56055726
Oedema 33.63 9.69 497 230376 81423 55979771
Angina pectoris 33.53 9.69 213 230660 27763 56033431
Colitis ulcerative 32.73 9.69 31 230842 24360 56036834
Drug resistance 32.72 9.69 22 230851 20520 56040674
Ill-defined disorder 32.70 9.69 157 230716 68386 55992808
Pulseless electrical activity 32.59 9.69 82 230791 6942 56054252
Coma 32.49 9.69 130 230743 59525 56001669
Hepatic ischaemia 32.49 9.69 24 230849 594 56060600
Altered state of consciousness 32.39 9.69 28 230845 22993 56038201
International normalised ratio increased 31.85 9.69 298 230575 43743 56017451
Tongue oedema 31.74 9.69 58 230815 3934 56057260
Intentional overdose 31.35 9.69 158 230715 67959 55993235
Hypoaldosteronism 31.31 9.69 15 230858 160 56061034
Body temperature increased 31.16 9.69 58 230815 34184 56027010
Hyperlipidaemia 31.14 9.69 152 230721 17957 56043237
Discomfort 31.14 9.69 402 230471 141359 55919835
Epilepsy 30.55 9.69 35 230838 25196 56035998
General physical health deterioration 30.41 9.69 502 230371 169508 55891686
Caesarean section 30.29 9.69 14 230859 16077 56045117
Impaired healing 30.22 9.69 220 230653 86621 55974573
Dysgeusia 30.17 9.69 278 230595 40637 56020557
Vision blurred 30.15 9.69 493 230380 82450 55978744
Blood glucose decreased 29.86 9.69 156 230717 18931 56042263
Myocardial ischaemia 29.54 9.69 113 230760 12003 56049191
Sedation complication 29.41 9.69 6 230867 11666 56049528
Atrioventricular block first degree 29.35 9.69 77 230796 6688 56054506
Vomiting 28.92 9.69 2395 228478 495833 55565361
Drug reaction with eosinophilia and systemic symptoms 28.77 9.69 50 230823 30254 56030940
Blood loss anaemia 28.70 9.69 87 230786 8210 56052984
Abnormal dreams 28.65 9.69 96 230777 9553 56051641
Allergic cough 27.81 9.69 21 230852 538 56060656
Panniculitis 27.12 9.69 4 230869 9838 56051356
Irritable bowel syndrome 27.03 9.69 167 230706 68291 55992903
Encephalomalacia 27.03 9.69 19 230854 434 56060760
Grip strength decreased 26.92 9.69 135 230738 16121 56045073
Blood pressure systolic abnormal 26.88 9.69 4 230869 9773 56051421
Hypoaesthesia 26.77 9.69 765 230108 140726 55920468
Facet joint syndrome 26.67 9.69 74 230799 6643 56054551
Sight disability 26.63 9.69 12 230861 110 56061084
Dry mouth 26.54 9.69 390 230483 63815 55997379
Oedema peripheral 26.10 9.69 902 229971 170352 55890842
Syncope 26.02 9.69 604 230269 107595 55953599
Blood cholesterol increased 25.86 9.69 430 230443 72149 55989045
Drug dispensed to wrong patient 25.78 9.69 14 230859 198 56060996
Blood potassium decreased 25.67 9.69 257 230616 38415 56022779
Alanine aminotransferase increased 25.10 9.69 254 230619 93408 55967786
Blood potassium increased 24.92 9.69 138 230735 17123 56044071
Coronary artery occlusion 24.84 9.69 79 230794 7650 56053544
Factor VII deficiency 24.54 9.69 8 230865 26 56061168
Erythema 24.53 9.69 471 230402 155468 55905726
Body temperature decreased 24.31 9.69 23 230850 18085 56043109
C-reactive protein abnormal 24.22 9.69 74 230799 36735 56024459
Therapy cessation 24.17 9.69 193 230680 27071 56034123
Depression 24.12 9.69 935 229938 179182 55882012
Lymphopenia 24.09 9.69 20 230853 16754 56044440
Dysphagia 24.08 9.69 471 230402 81476 55979718
Haematotoxicity 24.07 9.69 3 230870 8380 56052814
Toxic skin eruption 24.06 9.69 9 230864 11730 56049464
Colitis ischaemic 24.06 9.69 93 230780 9927 56051267
Weight decreased 23.95 9.69 1212 229661 239502 55821692
Neutrophil count decreased 23.83 9.69 114 230759 49708 56011486
Hepatorenal syndrome 23.52 9.69 33 230840 1787 56059407
Hepatitis 23.50 9.69 71 230802 35370 56025824
Synostosis 23.50 9.69 9 230864 52 56061142
Diabetic ketoacidosis 23.44 9.69 145 230728 18726 56042468
Chronic obstructive pulmonary disease 23.43 9.69 348 230525 57067 56004127
Thermohypoaesthesia 23.41 9.69 11 230862 112 56061082
Progressive multifocal leukoencephalopathy 23.33 9.69 10 230863 12003 56049191
Nodal rhythm 23.23 9.69 31 230842 1600 56059594
Device expulsion 23.19 9.69 57 230816 30392 56030802
Adjustment disorder with depressed mood 23.08 9.69 59 230814 5044 56056150
Lymphomatoid papulosis 22.91 9.69 11 230862 118 56061076
Full blood count decreased 22.77 9.69 169 230704 23180 56038014
Shock 22.77 9.69 160 230713 21568 56039626
Product use in unapproved indication 22.56 9.69 424 230449 140398 55920796
Rotator cuff repair 22.56 9.69 33 230840 1857 56059337
Foetal death 22.52 9.69 4 230869 8583 56052611
Neurotoxicity 22.48 9.69 19 230854 15776 56045418
Muscle relaxant therapy 22.39 9.69 12 230861 165 56061029
Blood pressure abnormal 22.31 9.69 113 230760 13547 56047647
Fibromyalgia 22.30 9.69 356 230517 59247 56001947
Drug eruption 22.26 9.69 45 230828 25718 56035476
Amnesia 22.24 9.69 289 230584 46033 56015161
Osmolar gap increased 22.14 9.69 7 230866 20 56061174
Diabetic neuropathy 22.03 9.69 48 230825 3700 56057494
Feeling abnormal 21.96 9.69 710 230163 132892 55928302
Body height decreased 21.85 9.69 85 230788 9100 56052094
Rash 21.76 9.69 1734 229139 491313 55569881
Septic shock 21.70 9.69 153 230720 60682 56000512
Hepatocellular injury 21.50 9.69 48 230825 26466 56034728
Hepatic cytolysis 21.30 9.69 9 230864 10897 56050297
Glomerulonephritis membranous 21.23 9.69 19 230854 621 56060573
Hypersensitivity 21.21 9.69 848 230025 255560 55805634
Dilatation atrial 21.21 9.69 32 230841 1851 56059343
Product coating issue 21.21 9.69 8 230865 44 56061150
Inflammation 20.78 9.69 182 230691 68889 55992305
Nodular rash 20.74 9.69 12 230861 193 56061001
Bone marrow failure 20.73 9.69 54 230819 28232 56032962
Sinus arrhythmia 20.68 9.69 27 230846 1364 56059830
Anhedonia 20.61 9.69 88 230785 9826 56051368
Abortion induced 20.44 9.69 7 230866 9638 56051556
Pancytopenia 20.44 9.69 249 230624 88466 55972728
Pharyngeal oedema 20.38 9.69 108 230765 13177 56048017
Ventricular fibrillation 20.34 9.69 94 230779 10858 56050336
Upper gastrointestinal haemorrhage 19.91 9.69 129 230744 16925 56044269
Gout 19.89 9.69 101 230772 12120 56049074
Osteoarthritis 19.85 9.69 450 230423 79846 55981348
Condition aggravated 19.84 9.69 1185 229688 343713 55717481
Blood parathyroid hormone decreased 19.68 9.69 5 230868 8359 56052835
Thrombotic microangiopathy 19.65 9.69 7 230866 9404 56051790
Therapy partial responder 19.62 9.69 4 230869 7781 56053413
Neutropenic sepsis 19.57 9.69 20 230853 15165 56046029
Lichen planus 19.46 9.69 33 230840 2109 56059085
Product substitution issue 19.29 9.69 114 230759 14485 56046709
Cholestasis 19.25 9.69 52 230821 26861 56034333
Hyponatraemia 19.24 9.69 552 230321 101587 55959607
Fluid intake reduced 19.21 9.69 42 230831 3245 56057949
Electrocardiogram T wave abnormal 19.18 9.69 34 230839 2252 56058942
Peripheral venous disease 19.08 9.69 87 230786 9992 56051202
Dislocation of vertebra 18.94 9.69 57 230816 5358 56055836
Oedema mouth 18.92 9.69 34 230839 2276 56058918
Tuberculosis 18.68 9.69 11 230862 11018 56050176
Gamma-glutamyltransferase increased 18.55 9.69 65 230808 30940 56030254
Haemophagocytic lymphohistiocytosis 18.53 9.69 8 230865 9564 56051630
Peripheral swelling 18.41 9.69 781 230092 233945 55827249
Lip dry 18.39 9.69 84 230789 9656 56051538
Decreased appetite 18.27 9.69 1086 229787 218145 55843049
Cytokine release syndrome 18.21 9.69 11 230862 10864 56050330
Transcription medication error 18.18 9.69 11 230862 193 56061001
Fear 18.17 9.69 114 230759 14794 56046400
Pulmonary fibrosis 18.06 9.69 62 230811 29696 56031498
Adactyly 18.06 9.69 7 230866 42 56061152
Osteoporosis 18.04 9.69 132 230741 51920 56009274
Essential hypertension 17.95 9.69 51 230822 4642 56056552
Peripheral vascular disorder 17.93 9.69 58 230815 5667 56055527
Blood urea increased 17.90 9.69 166 230707 24307 56036887
Bone erosion 17.88 9.69 21 230852 14953 56046241
Rash maculo-papular 17.70 9.69 60 230813 28847 56032347
Hypergammaglobulinaemia 17.59 9.69 15 230858 459 56060735
Muscle rigidity 17.58 9.69 11 230862 10660 56050534
Abdominal pain upper 17.55 9.69 897 229976 177416 55883778
Eosinophilic oesophagitis 17.42 9.69 12 230861 265 56060929
Eosinophilia 17.40 9.69 35 230838 20042 56041152
Ventricular hypertrophy 17.39 9.69 40 230833 3198 56057996
Hypophagia 17.32 9.69 188 230685 28688 56032506
Blood creatinine increased 17.27 9.69 441 230432 79750 55981444
Liver disorder 17.12 9.69 109 230764 44261 56016933
Charles Bonnet syndrome 17.05 9.69 5 230868 10 56061184
Schizophrenia 17.05 9.69 11 230862 10488 56050706
Therapeutic response unexpected 16.98 9.69 124 230749 16920 56044274
Sleep disorder due to a general medical condition 16.97 9.69 8 230865 9082 56052112
Immunodeficiency 16.90 9.69 25 230848 16132 56045062
Myalgia 16.88 9.69 682 230191 131343 55929851
Expired product administered 16.87 9.69 56 230817 5546 56055648
Creatinine renal clearance decreased 16.77 9.69 21 230852 14538 56046656
Poisoning deliberate 16.76 9.69 10 230863 9943 56051251
BRASH syndrome 16.67 9.69 12 230861 285 56060909
Sinusitis 16.65 9.69 652 230221 196929 55864265
Unresponsive to stimuli 16.54 9.69 201 230672 31524 56029670
Nervousness 16.53 9.69 187 230686 28828 56032366
Cerebral thrombosis 16.48 9.69 26 230847 1564 56059630
Cholelithiasis 16.41 9.69 240 230633 39224 56021970
Suspected suicide attempt 16.28 9.69 9 230864 132 56061062
Pneumonia 16.24 9.69 1443 229430 405655 55655539
Low birth weight baby 16.23 9.69 3 230870 6255 56054939
Poor venous access 16.09 9.69 16 230857 12290 56048904
Multimorbidity 16.08 9.69 15 230858 518 56060676
Premature labour 16.06 9.69 15 230858 11867 56049327
Graft versus host disease 16.06 9.69 4 230869 6777 56054417
Polyneuropathy 15.91 9.69 18 230855 13032 56048162
Visual acuity reduced 15.88 9.69 142 230731 20584 56040610
Pneumonitis 15.82 9.69 71 230802 31493 56029701
Lymphocyte count decreased 15.77 9.69 60 230813 27879 56033315
Torsade de pointes 15.71 9.69 96 230777 12344 56048850
Nephrogenic systemic fibrosis 15.62 9.69 47 230826 4418 56056776
Infective pulmonary exacerbation of cystic fibrosis 15.51 9.69 7 230866 8150 56053044
Accelerated hypertension 15.35 9.69 13 230860 394 56060800
Dizziness postural 15.35 9.69 60 230813 6438 56054756
Ankylosing spondylitis 15.33 9.69 11 230862 9919 56051275
Aphthous ulcer 15.29 9.69 16 230857 12003 56049191
Dystonia 15.29 9.69 17 230856 12404 56048790
Hereditary angioedema with normal C1 esterase inhibitor 15.25 9.69 4 230869 4 56061190
Electrocardiogram T wave peaked 15.12 9.69 10 230863 206 56060988
Muscular weakness 15.12 9.69 547 230326 103905 55957289
Drug clearance decreased 15.11 9.69 23 230850 1341 56059853
Extrapyramidal disorder 15.11 9.69 17 230856 12339 56048855
Bezoar 15.06 9.69 23 230850 1345 56059849
Paraesthesia 15.06 9.69 667 230206 129847 55931347
Pre-eclampsia 15.04 9.69 8 230865 8478 56052716
Diffuse large B-cell lymphoma 15.03 9.69 5 230868 7011 56054183
Anxiety 14.99 9.69 951 229922 192221 55868973
Asthma 14.98 9.69 350 230523 112420 55948774
Neuroleptic malignant syndrome 14.92 9.69 15 230858 11463 56049731
Blood pressure systolic increased 14.91 9.69 102 230771 40734 56020460
Wheezing 14.83 9.69 408 230465 74618 55986576
Epstein-Barr virus infection 14.83 9.69 6 230867 7457 56053737
Stridor 14.80 9.69 38 230835 3257 56057937
Skin exfoliation 14.80 9.69 223 230650 36677 56024517
Factor VIII inhibition 14.70 9.69 6 230867 42 56061152
Walking aid user 14.61 9.69 71 230802 8372 56052822
Respiratory disorder 14.38 9.69 81 230792 33876 56027318
Oral herpes 14.37 9.69 47 230826 22843 56038351
Application site nodule 14.36 9.69 4 230869 6 56061188
Urethral prolapse 14.36 9.69 4 230869 6 56061188
Diverticulum 14.36 9.69 86 230787 10980 56050214
Left ventricular hypertrophy 14.28 9.69 49 230824 4935 56056259
Non-cardiac chest pain 14.28 9.69 55 230818 5861 56055333
Acne 14.26 9.69 42 230831 21094 56040100
Gait disturbance 14.16 9.69 812 230061 162509 55898685
Transient psychosis 14.13 9.69 6 230867 47 56061147
Cognitive disorder 14.11 9.69 131 230742 49002 56012192
Transplant rejection 14.08 9.69 12 230861 9922 56051272
Haemodialysis 13.98 9.69 71 230802 8520 56052674
Hypertensive crisis 13.92 9.69 102 230771 13934 56047260
Gastrointestinal toxicity 13.88 9.69 4 230869 6152 56055042
Uveitis 13.86 9.69 15 230858 11080 56050114
Deformity 13.80 9.69 13 230860 10242 56050952
Anti-cyclic citrullinated peptide antibody 13.79 9.69 40 230833 3683 56057511
Metastases to liver 13.77 9.69 44 230829 21542 56039652
Withdrawal hypertension 13.76 9.69 8 230865 130 56061064
Facial nerve disorder 13.71 9.69 14 230859 541 56060653
Bronchiectasis 13.69 9.69 16 230857 11418 56049776
Paramnesia 13.64 9.69 4 230869 8 56061186
Emotional distress 13.58 9.69 184 230689 29579 56031615
Obesity 13.39 9.69 146 230727 22302 56038892
Sinus disorder 13.38 9.69 137 230736 20597 56040597
Glomerulonephropathy 13.34 9.69 7 230866 92 56061102
Food allergy 13.33 9.69 10 230863 8814 56052380
Eosinophilic pneumonia acute 13.29 9.69 11 230862 323 56060871
Productive cough 13.26 9.69 157 230716 56075 56005119
Urinary tract infection 13.24 9.69 1152 229721 239361 55821833
Pulmonary toxicity 13.16 9.69 8 230865 7875 56053319
Cerebral atrophy 12.95 9.69 46 230827 4714 56056480
Blood electrolytes abnormal 12.92 9.69 18 230855 968 56060226
Flatulence 12.90 9.69 190 230683 31098 56030096
Exercise tolerance increased 12.90 9.69 5 230868 30 56061164
Oral candidiasis 12.86 9.69 37 230836 18726 56042468
Lacunar infarction 12.84 9.69 35 230838 3110 56058084
Liver injury 12.79 9.69 242 230631 41606 56019588
Gastric ulcer helicobacter 12.76 9.69 4 230869 11 56061183
Fear of eating 12.76 9.69 11 230862 342 56060852
Acute myeloid leukaemia 12.74 9.69 32 230841 16940 56044254
Mydriasis 12.72 9.69 16 230857 11055 56050139
Shock haemorrhagic 12.69 9.69 11 230862 9022 56052172
Retching 12.67 9.69 97 230776 13433 56047761
Chromatopsia 12.66 9.69 12 230861 423 56060771
Blood lactate dehydrogenase increased 12.60 9.69 43 230830 20632 56040562
Apparent death 12.56 9.69 20 230853 1213 56059981
Ventricular tachycardia 12.54 9.69 115 230758 16786 56044408
Demyelination 12.50 9.69 5 230868 6257 56054937
Diabetic gastroparesis 12.49 9.69 9 230864 214 56060980
Pharyngitis 12.39 9.69 37 230836 18501 56042693
Respiratory depression 12.28 9.69 20 230853 12415 56048779
Hypertensive emergency 12.28 9.69 23 230850 1590 56059604
Laryngotracheal oedema 12.25 9.69 5 230868 35 56061159
Mitral valve incompetence 12.22 9.69 121 230752 18032 56043162
Bradycardia 12.21 9.69 363 230510 67141 55994053
Carotid artery stenosis 12.14 9.69 46 230827 4864 56056330
Bundle branch block left 12.11 9.69 55 230818 6307 56054887
Joint range of motion decreased 12.07 9.69 158 230715 25207 56035987
Rectal haemorrhage 12.06 9.69 238 230635 41229 56019965
Craniosynostosis 12.05 9.69 8 230865 166 56061028
Hypercholesterolaemia 12.05 9.69 101 230772 14372 56046822
Immune thrombocytopenia 12.04 9.69 13 230860 9612 56051582
High density lipoprotein decreased 12.03 9.69 24 230849 1738 56059456
Musculoskeletal stiffness 12.03 9.69 520 230353 155487 55905707
Infusion site pain 11.92 9.69 24 230849 13738 56047456
Device difficult to use 11.90 9.69 16 230857 10745 56050449
Burn oesophageal 11.88 9.69 8 230865 170 56061024
Optic ischaemic neuropathy 11.87 9.69 18 230855 1046 56060148
Refusal of treatment by patient 11.78 9.69 47 230826 5091 56056103
Raynaud's phenomenon 11.72 9.69 19 230854 1170 56060024
Cataract 11.68 9.69 284 230589 50963 56010231
Erythema marginatum 11.63 9.69 4 230869 16 56061178
Cardioactive drug level increased 11.60 9.69 26 230847 2043 56059151
Lip oedema 11.59 9.69 36 230837 3442 56057752
Back disorder 11.51 9.69 76 230797 10037 56051157
Mouth swelling 11.50 9.69 40 230833 4057 56057137
Occult blood positive 11.46 9.69 35 230838 3316 56057878
Ischaemic neuropathy 11.44 9.69 3 230870 3 56061191
Lethargy 11.40 9.69 284 230589 51157 56010037
Catheterisation cardiac 11.36 9.69 41 230832 4234 56056960
Product solubility abnormal 11.35 9.69 15 230858 767 56060427
Uraemic encephalopathy 11.23 9.69 9 230864 252 56060942
Blood pressure diastolic decreased 11.23 9.69 41 230832 19282 56041912
Adverse drug reaction 11.18 9.69 348 230525 64784 55996410
Weight increased 11.18 9.69 801 230072 228902 55832292
Product odour abnormal 11.17 9.69 18 230855 1103 56060091
Haemorrhage intracranial 11.15 9.69 90 230783 12665 56048529
Foot deformity 11.11 9.69 55 230818 23770 56037424
Electrocardiogram ST segment depression 11.09 9.69 30 230843 2653 56058541
Blood triglycerides increased 11.09 9.69 84 230789 11593 56049601
Dialysis 11.09 9.69 73 230800 9629 56051565
Generalised tonic-clonic seizure 11.01 9.69 67 230806 27499 56033695
Laboratory test abnormal 11.00 9.69 152 230721 24543 56036651
Intestinal ischaemia 10.99 9.69 57 230816 6898 56054296
Concomitant disease aggravated 10.97 9.69 11 230862 8415 56052779
Premature rupture of membranes 10.92 9.69 3 230870 4762 56056432
Liver function test increased 10.91 9.69 69 230804 28064 56033130
Retroperitoneal oedema 10.76 9.69 4 230869 21 56061173
Conjunctivitis 10.71 9.69 38 230835 18022 56043172
Tonsillitis 10.70 9.69 4 230869 5216 56055978
High density lipoprotein abnormal 10.68 9.69 6 230867 91 56061103
Impaired driving ability 10.65 9.69 39 230834 4057 56057137
Fracture 10.63 9.69 38 230835 17980 56043214
Renal cyst 10.62 9.69 70 230803 9239 56051955
Atrioventricular block 10.57 9.69 56 230817 6831 56054363
Hypoglycaemic unconsciousness 10.56 9.69 14 230859 718 56060476
Forced expiratory volume decreased 10.56 9.69 3 230870 4657 56056537
Urinary tract candidiasis 10.55 9.69 12 230861 525 56060669
Blood pressure decreased 10.53 9.69 317 230556 58733 56002461
Feeling jittery 10.53 9.69 85 230788 11961 56049233
Gastric disorder 10.48 9.69 193 230680 33017 56028177
Coronary artery surgery 10.47 9.69 5 230868 53 56061141
Hypertensive urgency 10.43 9.69 8 230865 210 56060984
Ovarian cyst 10.42 9.69 29 230844 14837 56046357
Ageusia 10.42 9.69 87 230786 12364 56048830
Second primary malignancy 10.42 9.69 9 230864 7393 56053801
Ear pain 10.38 9.69 79 230794 30811 56030383
Visceral oedema 10.32 9.69 4 230869 24 56061170
Venous angioma of brain 10.23 9.69 3 230870 6 56061188
Gallbladder abscess 10.23 9.69 3 230870 6 56061188
Autonomic failure syndrome 10.23 9.69 3 230870 6 56061188
SUNCT syndrome 10.23 9.69 3 230870 6 56061188
Pharyngeal swelling 10.19 9.69 46 230827 5260 56055934
Choroidal effusion 10.12 9.69 11 230862 457 56060737
Jaundice cholestatic 10.09 9.69 5 230868 5514 56055680
Hypogammaglobulinaemia 10.08 9.69 7 230866 6419 56054775
Macular fibrosis 9.99 9.69 10 230863 377 56060817
Respiratory distress 9.98 9.69 184 230689 31483 56029711
Tubulointerstitial nephritis and uveitis syndrome 9.89 9.69 8 230865 227 56060967
Dysarthria 9.88 9.69 222 230651 39328 56021866
Mouth ulceration 9.87 9.69 76 230797 29564 56031630
Thrombosis 9.80 9.69 316 230557 59111 56002083
Haemorrhagic stroke 9.76 9.69 46 230827 5357 56055837
Venoocclusive liver disease 9.74 9.69 3 230870 4418 56056776
Restrictive cardiomyopathy 9.71 9.69 9 230864 308 56060886
Small intestinal ulcer haemorrhage 9.71 9.69 5 230868 63 56061131

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Angioedema 11144.74 11.03 5014 193759 28604 31469967
Myocardial infarction 640.34 11.03 1858 196915 111596 31386975
Cardiac failure congestive 629.50 11.03 1477 197296 77910 31420661
Hyperkalaemia 572.03 11.03 1253 197520 63098 31435473
Swollen tongue 535.83 11.03 523 198250 12339 31486232
Lip swelling 502.03 11.03 513 198260 12810 31485761
Off label use 423.71 11.03 974 197799 346300 31152271
Coronary artery disease 351.37 11.03 845 197928 45242 31453329
Acute kidney injury 323.11 11.03 2915 195858 276799 31221772
Completed suicide 298.91 11.03 1251 197522 90263 31408308
Drug abuse 271.89 11.03 105 198668 87653 31410918
Cerebrovascular accident 270.89 11.03 1101 197672 78383 31420188
Febrile neutropenia 268.45 11.03 222 198551 121627 31376944
Pyrexia 232.15 11.03 1049 197724 302791 31195780
Swelling face 230.28 11.03 451 198322 20939 31477632
General physical health deterioration 218.87 11.03 233 198540 113202 31385369
Neutropenia 199.94 11.03 359 198414 140005 31358566
Hypotension 196.06 11.03 2052 196721 202566 31296005
Interstitial lung disease 187.61 11.03 75 198698 61328 31437243
Acute myocardial infarction 173.00 11.03 704 198069 50119 31448452
Foetal exposure during pregnancy 155.81 11.03 33 198740 40843 31457728
Dizziness 153.20 11.03 1914 196859 197233 31301338
Drug hypersensitivity 127.71 11.03 836 197937 71763 31426808
Hepatic function abnormal 123.22 11.03 52 198721 41170 31457401
Pancreatitis 119.71 11.03 493 198280 35278 31463293
Coronary arterial stent insertion 117.69 11.03 136 198637 3912 31494659
Intestinal angioedema 114.21 11.03 45 198728 170 31498401
Drug ineffective 111.43 11.03 1779 196994 393794 31104777
Septic shock 105.48 11.03 157 198616 66001 31432570
Thrombocytopenia 103.19 11.03 502 198271 142245 31356326
Product use in unapproved indication 102.01 11.03 302 198471 98869 31399702
Dehydration 98.88 11.03 1162 197611 117949 31380622
Coronary artery bypass 96.25 11.03 134 198639 4665 31493906
C-reactive protein increased 95.90 11.03 98 198675 48552 31450019
Leukopenia 93.39 11.03 136 198637 57692 31440879
Pharyngeal oedema 92.00 11.03 145 198628 5651 31492920
Cholestasis 86.32 11.03 25 198748 25050 31473521
Anaphylactic reaction 85.60 11.03 390 198383 29163 31469408
Cytomegalovirus infection 84.38 11.03 25 198748 24682 31473889
Drug resistance 83.32 11.03 22 198751 23431 31475140
Condition aggravated 82.44 11.03 646 198127 163363 31335208
Rheumatoid arthritis 79.61 11.03 110 198663 47699 31450872
Treatment failure 79.46 11.03 83 198690 40709 31457862
Product dose omission issue 78.90 11.03 1010 197763 104576 31393995
Blood potassium increased 78.38 11.03 243 198530 15102 31483469
Hepatocellular injury 76.93 11.03 20 198753 21524 31477047
Hypotensive transfusion reaction 76.35 11.03 20 198753 6 31498565
Disseminated intravascular coagulation 75.40 11.03 18 198755 20519 31478052
Suspected suicide 74.03 11.03 109 198664 3998 31494573
Agranulocytosis 69.87 11.03 23 198750 21224 31477347
Bronchopulmonary aspergillosis 69.27 11.03 4 198769 13630 31484941
Blood glucose increased 67.66 11.03 632 198141 60451 31438120
Altered state of consciousness 63.79 11.03 26 198747 21025 31477546
Pancytopenia 62.49 11.03 308 198465 87008 31411563
Product use issue 61.89 11.03 168 198605 56591 31441980
Epilepsy 60.57 11.03 28 198745 21013 31477558
Chest pain 60.44 11.03 1050 197723 115907 31382664
Bone marrow failure 59.17 11.03 53 198720 27955 31470616
Myelosuppression 59.03 11.03 11 198762 14909 31483662
Hypovolaemia 58.95 11.03 149 198624 8223 31490348
Mental status changes 58.28 11.03 406 198367 35562 31463009
Coma 56.91 11.03 107 198666 41043 31457528
Cough 56.18 11.03 1171 197602 133643 31364928
Blood pressure inadequately controlled 55.69 11.03 73 198700 2396 31496175
Neutrophil count decreased 55.47 11.03 131 198642 46263 31452308
Hypertension 55.45 11.03 1119 197654 126981 31371590
Lactic acidosis 55.02 11.03 366 198407 31571 31467000
Syncope 54.26 11.03 792 197981 84390 31414181
Sopor 54.09 11.03 5 198768 11547 31487024
Synovitis 53.25 11.03 7 198766 12276 31486295
Intentional product use issue 53.10 11.03 147 198626 49200 31449371
Fatigue 53.09 11.03 2589 196184 332617 31165954
Mucosal inflammation 51.70 11.03 85 198688 34342 31464229
Sepsis 51.41 11.03 658 198115 151271 31347300
Malignant neoplasm progression 49.15 11.03 292 198481 78706 31419865
Renal injury 48.22 11.03 162 198611 10503 31488068
Cardiac disorder 48.16 11.03 415 198358 38799 31459772
Premature baby 47.59 11.03 27 198746 18039 31480532
Hypertensive emergency 46.88 11.03 43 198730 935 31497636
Oral allergy syndrome 46.52 11.03 14 198759 16 31498555
Device interaction 46.16 11.03 34 198739 536 31498035
Blood lactate dehydrogenase increased 46.03 11.03 36 198737 20303 31478268
Pneumonia 45.89 11.03 1681 197092 333631 31164940
Multiple organ dysfunction syndrome 45.17 11.03 247 198526 67956 31430615
Gamma-glutamyltransferase increased 44.35 11.03 66 198707 27759 31470812
Injury 44.24 11.03 242 198531 19467 31479104
Pneumocystis jirovecii pneumonia 42.98 11.03 31 198742 18220 31480351
Dysphagia 42.73 11.03 551 198222 57125 31441446
International normalised ratio increased 42.36 11.03 452 198321 44771 31453800
Lymphocyte count decreased 41.36 11.03 41 198732 20608 31477963
Alanine aminotransferase increased 41.30 11.03 286 198487 74370 31424201
Aspergillus infection 40.59 11.03 11 198762 11517 31487054
Hyperthermia 40.39 11.03 7 198766 9997 31488574
Tongue oedema 39.50 11.03 65 198708 2628 31495943
Renal tubular necrosis 38.52 11.03 189 198584 14570 31484001
Electrocardiogram T wave peaked 38.30 11.03 30 198743 521 31498050
Pancreatitis acute 38.01 11.03 283 198490 25317 31473254
Infusion related reaction 37.62 11.03 164 198609 47891 31450680
Hepatitis 37.50 11.03 50 198723 22016 31476555
Toxic skin eruption 37.21 11.03 9 198764 10171 31488400
Immune reconstitution inflammatory syndrome 37.09 11.03 4 198769 8174 31490397
Liver disorder 37.03 11.03 82 198691 29625 31468946
Hypophagia 37.00 11.03 251 198522 21791 31476780
Vascular graft 36.99 11.03 46 198727 1431 31497140
Drug interaction 36.78 11.03 1011 197762 207532 31291039
Feeling abnormal 36.67 11.03 531 198242 56471 31442100
Intentional self-injury 36.38 11.03 19 198754 13296 31485275
Asthma 36.11 11.03 141 198632 42470 31456101
Drug dependence 35.56 11.03 54 198719 22525 31476046
Lymphopenia 35.53 11.03 23 198750 14306 31484265
Fear 35.36 11.03 140 198633 9834 31488737
Platelet count decreased 35.24 11.03 484 198289 109951 31388620
Lung disorder 34.94 11.03 96 198677 32216 31466355
Psoriasis 34.88 11.03 447 198326 46272 31452299
Cardiac failure 34.60 11.03 358 198415 85595 31412976
Infection 34.32 11.03 338 198435 81593 31416978
Drug reaction with eosinophilia and systemic symptoms 34.12 11.03 87 198686 29931 31468640
Angina unstable 34.11 11.03 150 198623 11045 31487526
Pneumonitis 33.95 11.03 90 198683 30562 31468009
Aplastic anaemia 33.91 11.03 8 198765 9195 31489376
Blood urea increased 33.53 11.03 303 198470 28709 31469862
Neuroleptic malignant syndrome 33.21 11.03 34 198739 16835 31481736
Pathogen resistance 33.20 11.03 7 198766 8694 31489877
Therapeutic product effect incomplete 32.48 11.03 152 198621 43544 31455027
Pelvic mass 32.45 11.03 19 198754 198 31498373
Asthenia 32.19 11.03 1720 197053 223035 31275536
Anhedonia 31.86 11.03 111 198662 7331 31491240
Orbital myositis 31.65 11.03 16 198757 121 31498450
Graft versus host disease 31.50 11.03 13 198760 10434 31488137
Product quality issue 31.05 11.03 190 198583 15921 31482650
Thrombotic microangiopathy 30.96 11.03 10 198763 9341 31489230
Blood creatinine increased 30.86 11.03 754 198019 88324 31410247
Dysphonia 30.78 11.03 228 198545 20363 31478208
Renal failure 30.75 11.03 1001 197772 122329 31376242
Hyperbilirubinaemia 30.71 11.03 32 198741 15718 31482853
Ischaemic cardiomyopathy 30.68 11.03 94 198679 5803 31492768
Exposure during pregnancy 30.66 11.03 8 198765 8590 31489981
Muscle spasms 30.59 11.03 600 198173 67718 31430853
Seizure 30.50 11.03 441 198332 99327 31399244
Lower respiratory tract infection 30.45 11.03 84 198689 28153 31470418
Vision blurred 30.43 11.03 399 198374 41516 31457055
Pharyngeal swelling 30.38 11.03 47 198726 1802 31496769
Venoocclusive liver disease 30.34 11.03 5 198768 7407 31491164
Therapy partial responder 30.30 11.03 3 198770 6559 31492012
Hepatic cytolysis 30.23 11.03 15 198758 10808 31487763
Dysgeusia 30.21 11.03 251 198522 23215 31475356
Low birth weight baby 30.15 11.03 4 198769 6966 31491605
Haemophagocytic lymphohistiocytosis 29.98 11.03 18 198755 11660 31486911
Eosinophilia 29.97 11.03 63 198710 23190 31475381
Ageusia 29.94 11.03 127 198646 9204 31489367
Pneumonia aspiration 29.80 11.03 133 198640 38593 31459978
Bradycardia 29.75 11.03 605 198168 68722 31429849
Blood urea abnormal 29.56 11.03 30 198743 742 31497829
Drug intolerance 28.44 11.03 200 198573 51833 31446738
Drooling 28.27 11.03 61 198712 3034 31495537
Allergic cough 28.14 11.03 10 198763 26 31498545
Wheezing 28.01 11.03 347 198426 35639 31462932
Cytokine release syndrome 27.98 11.03 38 198735 16604 31481967
Mouth swelling 27.90 11.03 43 198730 1643 31496928
Blood glucose decreased 27.90 11.03 153 198620 12318 31486253
Pulmonary renal syndrome 27.80 11.03 16 198757 161 31498410
Mydriasis 27.77 11.03 4 198769 6548 31492023
Anaemia 27.66 11.03 1077 197696 212445 31286126
Intentional dose omission 27.65 11.03 57 198716 2745 31495826
Myocardial ischaemia 27.50 11.03 189 198584 16478 31482093
Emotional distress 27.48 11.03 169 198604 14187 31484384
Transaminases increased 27.31 11.03 71 198702 24270 31474301
Aspartate aminotransferase increased 27.00 11.03 257 198516 62462 31436109
Product substitution issue 26.95 11.03 124 198649 9308 31489263
Haematotoxicity 26.70 11.03 6 198767 7131 31491440
Status epilepticus 26.68 11.03 22 198751 12084 31486487
Drug-induced liver injury 26.63 11.03 72 198701 24291 31474280
Depressed level of consciousness 26.54 11.03 138 198635 38463 31460108
Potassium wasting nephropathy 26.44 11.03 13 198760 92 31498479
Therapy cessation 26.20 11.03 173 198600 14882 31483689
Toxic epidermal necrolysis 25.92 11.03 52 198721 19472 31479099
Hypoglycaemia 25.77 11.03 456 198317 50490 31448081
Colitis ulcerative 25.77 11.03 48 198725 18481 31480090
Transient ischaemic attack 25.67 11.03 247 198526 23809 31474762
Diabetic neuropathy 25.46 11.03 68 198705 3881 31494690
Orthostatic hypotension 25.42 11.03 247 198526 23872 31474699
Ulnar nerve palsy 25.41 11.03 7 198766 4 31498567
Oxygen saturation decreased 25.29 11.03 192 198581 48923 31449648
Bronchiectasis 25.28 11.03 8 198765 7572 31490999
Post transplant lymphoproliferative disorder 25.09 11.03 4 198769 6072 31492499
Substance abuse 24.88 11.03 7 198766 7151 31491420
Transplant rejection 24.87 11.03 15 198758 9693 31488878
Labelled drug-drug interaction medication error 24.28 11.03 28 198745 13135 31485436
Blood electrolytes abnormal 23.75 11.03 29 198744 885 31497686
Neurotoxicity 23.49 11.03 41 198732 16185 31482386
Schizophrenia 23.47 11.03 20 198753 10810 31487761
Laryngeal oedema 23.43 11.03 58 198715 3159 31495412
Oropharyngeal swelling 23.34 11.03 21 198752 445 31498126
Cystitis haemorrhagic 22.96 11.03 3 198770 5286 31493285
Pancreatitis necrotising 22.91 11.03 49 198724 2422 31496149
Glycosylated haemoglobin increased 22.87 11.03 127 198646 10273 31488298
Hyperlipidaemia 22.77 11.03 151 198622 13009 31485562
Prostate cancer recurrent 22.76 11.03 29 198744 925 31497646
Increased tendency to bruise 22.73 11.03 62 198711 3583 31494988
Tuberculosis 22.64 11.03 12 198761 8329 31490242
Accelerated hypertension 22.56 11.03 16 198757 237 31498334
Product complaint 22.45 11.03 81 198692 5443 31493128
Pseudomonas infection 22.42 11.03 23 198750 11378 31487193
Blood pressure increased 22.40 11.03 656 198117 78977 31419594
Tumour lysis syndrome 22.16 11.03 39 198734 15346 31483225
Enterocolitis 22.01 11.03 9 198764 7265 31491306
Nausea 21.96 11.03 2228 196545 305719 31192852
Similar reaction on previous exposure to drug 21.88 11.03 9 198764 39 31498532
Myelodysplastic syndrome 21.72 11.03 56 198717 19195 31479376
Swelling 21.69 11.03 342 198431 37016 31461555
Anal abscess 21.45 11.03 5 198768 5795 31492776
Vitreous floaters 21.37 11.03 57 198716 3250 31495321
Encephalitis 21.34 11.03 8 198765 6807 31491764
Coronary artery occlusion 21.15 11.03 124 198649 10232 31488339
Pancreatitis haemorrhagic 21.15 11.03 17 198756 307 31498264
Acute hepatic failure 20.98 11.03 30 198743 12829 31485742
No reaction on previous exposure to drug 20.91 11.03 10 198763 66 31498505
Second primary malignancy 20.80 11.03 9 198764 7023 31491548
Erythema 20.69 11.03 367 198406 80038 31418533
Unevaluable event 20.53 11.03 287 198486 30288 31468283
Nodular rash 20.15 11.03 11 198762 99 31498472
Paraesthesia 20.13 11.03 477 198296 55594 31442977
Azotaemia 20.10 11.03 70 198703 4622 31493949
Eosinophil count increased 20.01 11.03 12 198761 7779 31490792
Myalgia 20.00 11.03 630 198143 76628 31421943
Productive cough 19.79 11.03 126 198647 33414 31465157
Polyneuropathy 19.69 11.03 32 198741 12990 31485581
Acute respiratory distress syndrome 19.66 11.03 83 198690 24457 31474114
Posterior reversible encephalopathy syndrome 19.46 11.03 18 198755 9349 31489222
Burning sensation 19.39 11.03 175 198598 16572 31481999
Maternal exposure during pregnancy 19.37 11.03 3 198770 4653 31493918
Product coating issue 19.22 11.03 7 198766 20 31498551
Pulmonary arterial hypertension 19.10 11.03 20 198753 9801 31488770
Hepatotoxicity 19.09 11.03 59 198714 19067 31479504
Acute myeloid leukaemia 19.07 11.03 57 198716 18615 31479956
Chronic kidney disease 18.88 11.03 339 198434 37636 31460935
Epstein-Barr virus infection 18.88 11.03 10 198763 6943 31491628
Generalised tonic-clonic seizure 18.84 11.03 63 198710 19868 31478703
Progressive multifocal leukoencephalopathy 18.79 11.03 18 198755 9195 31489376
Blood alkaline phosphatase increased 18.76 11.03 108 198665 29345 31469226
Cytopenia 18.65 11.03 25 198748 10985 31487586
Colitis 18.64 11.03 130 198643 33757 31464814
Gallbladder oedema 18.63 11.03 14 198759 228 31498343
Arteriosclerosis coronary artery 18.43 11.03 127 198646 11081 31487490
Miosis 18.36 11.03 16 198757 8554 31490017
Circulatory collapse 18.26 11.03 63 198710 19681 31478890
Blood bilirubin increased 18.26 11.03 137 198636 34999 31463572
Hepatic failure 18.21 11.03 125 198648 32577 31465994
Hepatocellular carcinoma 17.98 11.03 17 198756 8739 31489832
Diarrhoea 17.97 11.03 2496 196277 349913 31148658
Chronic graft versus host disease 17.89 11.03 3 198770 4389 31494182
Cytomegalovirus viraemia 17.78 11.03 10 198763 6715 31491856
Renal impairment neonatal 17.63 11.03 6 198767 13 31498558
Electrocardiogram change 17.61 11.03 21 198752 625 31497946
Hypoaesthesia 17.57 11.03 468 198305 55554 31443017
Hypoaesthesia oral 17.53 11.03 56 198717 3536 31495035
Akathisia 17.50 11.03 12 198761 7241 31491330
Gastric cancer 17.46 11.03 8 198765 6037 31492534
Dizziness postural 17.26 11.03 75 198698 5493 31493078
Sedation 17.21 11.03 61 198712 18904 31479667
Blood glucose abnormal 17.21 11.03 73 198700 5290 31493281
Postural orthostatic tachycardia syndrome 17.09 11.03 8 198765 50 31498521
Cholangitis 17.00 11.03 15 198758 7971 31490600
Acquired acrodermatitis enteropathica 16.96 11.03 5 198768 5 31498566
Eye swelling 16.92 11.03 107 198666 9069 31489502
Atrial fibrillation 16.89 11.03 874 197899 112909 31385662
Neutrophil count increased 16.81 11.03 47 198726 15684 31482887
Carcinoid tumour of the gastrointestinal tract 16.71 11.03 8 198765 53 31498518
Encephalopathy 16.69 11.03 127 198646 32347 31466224
Fall 16.66 11.03 1369 197404 184720 31313851
Pemphigus 16.59 11.03 31 198742 1388 31497183
Spur cell anaemia 16.58 11.03 8 198765 54 31498517
Stent placement 16.29 11.03 66 198707 4685 31493886
Delirium 16.05 11.03 174 198599 41247 31457324
Renal artery stenosis 16.00 11.03 39 198734 2103 31496468
Hypogammaglobulinaemia 15.94 11.03 11 198762 6616 31491955
Oedema mouth 15.93 11.03 28 198745 1195 31497376
Inflammation 15.84 11.03 93 198680 25148 31473423
Overdose 15.78 11.03 407 198366 84257 31414314
Device related infection 15.76 11.03 51 198722 16248 31482323
Hepatitis cholestatic 15.73 11.03 13 198760 7133 31491438
Stridor 15.72 11.03 41 198732 2306 31496265
Enlarged uvula 15.68 11.03 11 198762 160 31498411
Appendicitis 15.68 11.03 30 198743 11435 31487136
Pulmonary tuberculosis 15.66 11.03 5 198768 4706 31493865
Paraesthesia oral 15.61 11.03 55 198718 3653 31494918
Respiratory tract oedema 15.42 11.03 15 198758 352 31498219
Complications of transplanted kidney 15.36 11.03 4 198769 4301 31494270
Infective pulmonary exacerbation of cystic fibrosis 15.28 11.03 11 198762 6473 31492098
Death 15.25 11.03 2005 196768 358564 31140007
Haemorrhage intracranial 15.16 11.03 153 198620 14935 31483636
Kidney transplant rejection 15.12 11.03 14 198759 7268 31491303
Tachycardia 15.11 11.03 363 198410 75844 31422727
Hepatitis acute 15.02 11.03 12 198761 6697 31491874
Electrocardiogram QT prolonged 14.95 11.03 159 198614 37828 31460743
Respiratory tract infection 14.94 11.03 58 198715 17503 31481068
Cachexia 14.89 11.03 12 198761 6667 31491904
Benign gastrointestinal neoplasm 14.89 11.03 10 198763 135 31498436
Psychomotor hyperactivity 14.84 11.03 20 198753 8767 31489804
Stomatitis 14.76 11.03 167 198606 39271 31459300
Neutropenic sepsis 14.75 11.03 35 198738 12344 31486227
Essential hypertension 14.73 11.03 43 198730 2584 31495987
Aggression 14.71 11.03 156 198617 37135 31461436
Diabetic foot infection 14.70 11.03 19 198754 615 31497956
Blood pressure fluctuation 14.68 11.03 83 198690 22653 31475918
Cardiovascular disorder 14.68 11.03 105 198668 9273 31489298
Lymphoma 14.65 11.03 29 198744 10914 31487657
Urine oxalate increased 14.64 11.03 5 198768 11 31498560
Hyperuricaemia 14.63 11.03 15 198758 7423 31491148
Jaundice 14.39 11.03 121 198652 30166 31468405
Arteriosclerosis 14.30 11.03 116 198657 10651 31487920
Dyspnoea 14.25 11.03 2405 196368 341074 31157497
Poisoning deliberate 14.23 11.03 15 198758 7329 31491242
Peripheral vascular disorder 14.22 11.03 63 198710 4653 31493918
Adenovirus infection 14.20 11.03 6 198767 4748 31493823
Tympanic membrane disorder 14.18 11.03 7 198766 50 31498521
Lymphomatoid papulosis 14.14 11.03 11 198762 189 31498382
Pneumatosis intestinalis 14.13 11.03 3 198770 3708 31494863
Carcinoid tumour of the stomach 14.07 11.03 7 198766 51 31498520
Intestinal obstruction 13.99 11.03 74 198699 20536 31478035
Rash pruritic 13.84 11.03 219 198554 23719 31474852
Ankylosing spondylitis 13.83 11.03 10 198763 5871 31492700
Renal tubular acidosis 13.76 11.03 37 198736 2120 31496451
Blood cholesterol increased 13.62 11.03 164 198609 16729 31481842
Endometriosis male 13.55 11.03 5 198768 15 31498556
Osteonecrosis of jaw 13.51 11.03 58 198715 17013 31481558
Extrapyramidal disorder 13.49 11.03 34 198739 11744 31486827
Body temperature decreased 13.46 11.03 34 198739 11736 31486835
Oral candidiasis 13.46 11.03 31 198742 11046 31487525
Diverticulum 13.42 11.03 78 198695 6416 31492155
Drug level increased 13.41 11.03 73 198700 20113 31478458
Hypotonia 13.34 11.03 15 198758 7118 31491453
Cataract nuclear 13.32 11.03 16 198757 480 31498091
Alcoholic ketoacidosis 13.32 11.03 5 198768 16 31498555
Liver abscess 13.26 11.03 3 198770 3548 31495023
Musculoskeletal chest pain 13.24 11.03 100 198673 8985 31489586
Non-cardiac chest pain 13.20 11.03 56 198717 4059 31494512
Cerebral infarction 13.16 11.03 102 198671 25875 31472696
Uveitis 13.12 11.03 14 198759 6802 31491769
Epiglottic oedema 13.09 11.03 10 198763 167 31498404
Speech disorder 13.09 11.03 219 198554 23982 31474589
Tenosynovitis 13.08 11.03 5 198768 4205 31494366
Pericarditis 13.07 11.03 24 198749 9292 31489279
Gastrointestinal haemorrhage 13.05 11.03 638 198135 81911 31416660
Colorectal cancer 13.03 11.03 7 198766 4822 31493749
Erythema multiforme 13 11.03 19 198754 8052 31490519
Lip oedema 12.99 11.03 38 198735 2286 31496285
BK virus infection 12.87 11.03 8 198765 5087 31493484
Oedema genital 12.84 11.03 14 198759 377 31498194
Anal fistula 12.81 11.03 7 198766 4776 31493795
Myxoedema coma 12.75 11.03 12 198761 270 31498301
Dilatation atrial 12.71 11.03 33 198740 1851 31496720
Rash 12.67 11.03 1446 197327 200040 31298531
Penile swelling 12.66 11.03 20 198753 781 31497790
Blood sodium decreased 12.49 11.03 149 198624 15166 31483405
Sleep attacks 12.49 11.03 9 198764 137 31498434
Immunosuppressant drug level increased 12.41 11.03 9 198764 5276 31493295
Hepatic encephalopathy 12.39 11.03 44 198729 13627 31484944
Hyperammonaemia 12.36 11.03 11 198762 5822 31492749
Weaning failure 12.35 11.03 11 198762 230 31498341
Therapy non-responder 12.33 11.03 144 198629 33667 31464904
Suicide attempt 12.31 11.03 162 198611 37086 31461485
Pneumopericardium 12.30 11.03 8 198765 102 31498469
Vomiting projectile 12.27 11.03 17 198756 589 31497982
Lipoedema 12.23 11.03 3 198770 0 31498571
Pleural effusion 12.20 11.03 367 198406 74553 31424018
Behaviour disorder 12.18 11.03 6 198767 4341 31494230
Terminal state 12.16 11.03 4 198769 3694 31494877
Organising pneumonia 12.16 11.03 10 198763 5500 31493071
Application site infection 12.14 11.03 6 198767 43 31498528
White blood cell count decreased 12.13 11.03 437 198336 86961 31411610
Dystonia 12.11 11.03 29 198744 10196 31488375
Diabetic retinopathy 12.09 11.03 30 198743 1636 31496935
Osteoporosis 12.09 11.03 35 198738 11548 31487023
Throat tightness 12.08 11.03 86 198687 7583 31490988
Glossodynia 12.08 11.03 48 198725 3377 31495194
Endotracheal intubation complication 12.08 11.03 13 198760 345 31498226
Faeces discoloured 12.08 11.03 136 198637 13650 31484921
Meniere's disease 12.02 11.03 6 198767 44 31498527
Pollakiuria 12.00 11.03 168 198605 17734 31480837
Cardiomyopathy 11.99 11.03 148 198625 15185 31483386
Adenocarcinoma pancreas 11.98 11.03 26 198747 1298 31497273
Food allergy 11.97 11.03 23 198750 1052 31497519
Klebsiella infection 11.96 11.03 19 198754 7784 31490787
Skin odour abnormal 11.92 11.03 21 198752 898 31497673
Blood pressure diastolic abnormal 11.92 11.03 5 198768 3974 31494597
Toxicity to various agents 11.89 11.03 978 197795 180509 31318062
Erectile dysfunction 11.89 11.03 178 198595 19057 31479514
Plasma cell myeloma 11.84 11.03 267 198506 56264 31442307
Osteonecrosis 11.72 11.03 46 198727 13838 31484733
Graft versus host disease in skin 11.64 11.03 4 198769 3593 31494978
Albumin urine present 11.61 11.03 13 198760 361 31498210
Hypoglycaemic unconsciousness 11.60 11.03 19 198754 765 31497806
Gout 11.56 11.03 169 198604 18005 31480566
Sleep disorder due to a general medical condition 11.53 11.03 5 198768 3897 31494674
Acute cutaneous lupus erythematosus 11.48 11.03 7 198766 79 31498492
Atrial septal defect 11.46 11.03 16 198757 6911 31491660
Contrast media reaction 11.44 11.03 20 198753 850 31497721
Inflammatory marker increased 11.36 11.03 6 198767 4172 31494399
Hypersensitivity 11.29 11.03 442 198331 55301 31443270
Bronchospasm 11.25 11.03 29 198744 9943 31488628
Rash maculo-papular 11.23 11.03 105 198668 25614 31472957
Sinus node dysfunction 11.21 11.03 51 198722 3809 31494762
Clostridium difficile infection 11.20 11.03 63 198710 17216 31481355
Prostate cancer 11.20 11.03 167 198606 37434 31461137
Macroglossia 11.19 11.03 13 198760 376 31498195
Virologic failure 11.18 11.03 3 198770 3162 31495409
Musculoskeletal stiffness 11.15 11.03 187 198586 41138 31457433
Acute coronary syndrome 11.13 11.03 126 198647 12663 31485908
Pneumonia fungal 11.10 11.03 14 198759 6315 31492256
Graft versus host disease in gastrointestinal tract 11.03 11.03 4 198769 3475 31495096

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Angioedema 12369.34 9.82 6131 333057 60479 70528777
Myocardial infarction 1355.31 9.82 2712 336476 168933 70420323
Cardiac failure congestive 1287.89 9.82 2317 336871 133140 70456116
Hyperkalaemia 782.22 9.82 1635 337553 104956 70484300
Swollen tongue 768.57 9.82 917 338271 36129 70553127
Acute kidney injury 714.38 9.82 4286 334902 470338 70118918
Coronary artery disease 694.99 9.82 1149 338039 61587 70527669
Intestinal angioedema 689.74 9.82 227 338961 625 70588631
Cerebrovascular accident 625.05 9.82 1801 337387 141669 70447587
Lip swelling 611.54 9.82 784 338404 33270 70555986
Off label use 559.50 9.82 1763 337425 741297 69847959
Completed suicide 520.71 9.82 2309 336879 224826 70364430
Acute myocardial infarction 379.13 9.82 977 338211 71910 70517346
Drug abuse 358.44 9.82 128 339060 147128 70442128
Drug ineffective 352.38 9.82 2845 336343 936907 69652349
Pyrexia 318.96 9.82 1657 337531 605295 69983961
Febrile neutropenia 307.28 9.82 314 338874 204004 70385252
Rheumatoid arthritis 252.75 9.82 646 338542 291159 70298097
Neutropenia 242.75 9.82 544 338644 256612 70332644
Hypotension 238.02 9.82 2966 336222 401415 70187841
Swelling face 234.45 9.82 750 338438 62414 70526842
C-reactive protein increased 206.77 9.82 137 339051 110380 70478876
Coronary arterial stent insertion 200.98 9.82 190 338998 5697 70583559
Interstitial lung disease 194.19 9.82 131 339057 104554 70484702
Dehydration 184.69 9.82 1771 337417 224371 70364885
Coronary artery bypass 181.30 9.82 180 339008 5740 70583516
Lactic acidosis 175.95 9.82 696 338492 64328 70524928
Drug intolerance 169.26 9.82 535 338653 225152 70364104
Infusion related reaction 156.88 9.82 456 338732 197078 70392178
Dizziness 154.05 9.82 3093 336095 461048 70128208
Pancreatitis 153.90 9.82 651 338537 62017 70527239
Synovitis 152.15 9.82 239 338949 128989 70460267
Hepatic function abnormal 150.85 9.82 68 339120 67928 70521328
Renal failure 150.54 9.82 1473 337715 187597 70401659
General physical health deterioration 141.90 9.82 613 338575 235418 70353838
Hypotensive transfusion reaction 140.78 9.82 39 339149 43 70589213
Hypovolaemia 129.81 9.82 256 338932 15737 70573519
Blood glucose increased 127.03 9.82 886 338302 102096 70487160
Contraindicated product administered 122.67 9.82 290 338898 134322 70454934
Maternal exposure during pregnancy 122.32 9.82 228 338960 115117 70474139
Suspected suicide 120.29 9.82 178 339010 8656 70580600
Mental status changes 118.43 9.82 606 338582 62495 70526761
Cytomegalovirus infection 112.44 9.82 26 339162 39732 70549524
Hypertension 111.82 9.82 2013 337175 294020 70295236
Infection 108.82 9.82 578 338610 210207 70379049
Thrombocytopenia 108.81 9.82 683 338505 238427 70350829
Lower respiratory tract infection 105.27 9.82 237 338951 111676 70477580
Product dose omission issue 103.76 9.82 1537 337651 215931 70373325
Sopor 102.39 9.82 14 339174 31253 70558003
Injury 101.86 9.82 596 338592 64649 70524607
Leukopenia 101.59 9.82 224 338964 106336 70482920
Exposure during pregnancy 100.62 9.82 165 339023 87552 70501704
Chest pain 98.93 9.82 1720 337468 249540 70339716
Nasopharyngitis 96.87 9.82 643 338545 221563 70367693
Syncope 93.15 9.82 1206 337982 164503 70424753
Product use in unapproved indication 91.64 9.82 598 338590 206880 70382376
Septic shock 91.38 9.82 256 338932 112002 70477254
Renal injury 89.11 9.82 221 338967 15873 70573383
Angina unstable 88.80 9.82 219 338969 15674 70573582
Pharyngeal oedema 88.46 9.82 217 338971 15479 70573777
Agranulocytosis 88.29 9.82 41 339147 40257 70548999
Gastrointestinal haemorrhage 87.58 9.82 1024 338164 136384 70452872
Drug resistance 86.59 9.82 37 339151 38153 70551103
Blood potassium increased 85.09 9.82 306 338882 27020 70562236
Myelosuppression 84.68 9.82 20 339168 30125 70559131
Cardiac disorder 83.40 9.82 528 338660 58887 70530369
Asthenia 82.46 9.82 2814 336374 454852 70134404
Altered state of consciousness 78.43 9.82 47 339141 39975 70549281
Drug hypersensitivity 78.36 9.82 1723 337465 260736 70328520
Bronchopulmonary aspergillosis 77.54 9.82 6 339182 20996 70568260
Blood pressure fluctuation 76.45 9.82 102 339086 58910 70530346
Therapeutic product effect incomplete 75.29 9.82 306 338882 119576 70469680
Coma 75.08 9.82 209 338979 91635 70497621
Tongue oedema 73.81 9.82 118 339070 6141 70583115
Dysphagia 73.74 9.82 845 338343 111989 70477267
Sleep disorder due to general medical condition, insomnia type 72.82 9.82 40 339148 35692 70553564
Myocardial ischaemia 72.82 9.82 268 338920 23932 70565324
Malignant neoplasm progression 72.58 9.82 317 338871 121422 70467834
Cholestasis 72.53 9.82 73 339115 47799 70541457
Hepatocellular injury 72.48 9.82 68 339120 46023 70543233
Pancreatitis acute 72.46 9.82 416 338772 44808 70544448
Hypophagia 72.34 9.82 391 338797 41179 70548077
Transient ischaemic attack 71.91 9.82 420 338768 45524 70543732
International normalised ratio increased 71.71 9.82 644 338544 80082 70509174
Product quality issue 71.57 9.82 313 338875 30248 70559008
Joint swelling 70.69 9.82 822 338366 252389 70336867
Ischaemic cardiomyopathy 70.53 9.82 124 339064 6980 70582276
Mucosal inflammation 70.26 9.82 136 339052 67714 70521542
Intentional self-injury 69.65 9.82 32 339156 31618 70557638
Arthralgia 69.29 9.82 1855 337333 501535 70087721
Blood creatinine increased 68.66 9.82 1012 338176 141989 70447267
Bone marrow failure 68.42 9.82 80 339108 48930 70540326
Neutrophil count decreased 68.40 9.82 190 338998 83366 70505890
Epilepsy 67.37 9.82 52 339136 38732 70550524
Blood pressure inadequately controlled 66.74 9.82 106 339082 5486 70583770
Electrocardiogram T wave peaked 66.08 9.82 45 339143 830 70588426
Condition aggravated 65.79 9.82 1550 337638 426085 70163171
Gastrointestinal disorder 65.64 9.82 270 338918 105157 70484099
Blood urea increased 64.44 9.82 408 338780 45501 70543755
Premature delivery 62.13 9.82 13 339175 21291 70567965
Treatment failure 60.84 9.82 421 338767 143721 70445535
Product use issue 59.63 9.82 561 338627 179376 70409880
Oxygen saturation decreased 59.63 9.82 320 338868 116109 70473147
Pancytopenia 59.59 9.82 450 338738 150657 70438599
Abortion spontaneous 59.48 9.82 26 339162 26453 70562803
Depressed level of consciousness 58.85 9.82 217 338971 87214 70502042
Labile blood pressure 58.32 9.82 61 339127 2071 70587185
Arthropathy 58.17 9.82 449 338739 149608 70439648
Pneumocystis jirovecii pneumonia 58.00 9.82 36 339152 30046 70559210
Aspergillus infection 56.20 9.82 9 339179 17859 70571397
Stomatitis 55.40 9.82 373 338815 128138 70461118
Type 2 diabetes mellitus 54.77 9.82 380 338808 43700 70545556
Hyperlipidaemia 53.31 9.82 241 338947 23622 70565634
Systemic lupus erythematosus 52.78 9.82 279 338909 101623 70487633
Hypertensive emergency 52.76 9.82 62 339126 2401 70586855
Chronic kidney disease 52.65 9.82 484 338704 60573 70528683
Pneumonia 52.07 9.82 2326 336862 593906 69995350
Anhedonia 52.01 9.82 168 339020 14045 70575211
Bradycardia 51.86 9.82 861 338327 123754 70465502
Atrial fibrillation 51.77 9.82 1200 337988 183148 70406108
Therapy cessation 51.50 9.82 306 338882 33370 70555886
Asthma 51.37 9.82 352 338836 120441 70468815
Erythema 50.70 9.82 661 338527 198902 70390354
Blood pressure diastolic abnormal 50.63 9.82 7 339181 15497 70573759
Hand deformity 50.45 9.82 227 338961 86255 70503001
Vascular graft 50.30 9.82 54 339134 1890 70587366
Renal tubular necrosis 50.27 9.82 232 338956 22939 70566317
Hepatitis 50.18 9.82 102 339086 49878 70539378
Disseminated intravascular coagulation 50.03 9.82 52 339136 33546 70555710
Toxic skin eruption 49.92 9.82 17 339171 20145 70569111
Sedation 49.85 9.82 92 339096 46639 70542617
Lymphocyte count decreased 49.82 9.82 82 339106 43457 70545799
Hepatic enzyme increased 49.67 9.82 495 338693 156495 70432761
Liver disorder 49.65 9.82 141 339047 61427 70527829
Cardiomyopathy 49.27 9.82 253 338935 26120 70563136
Status epilepticus 49.19 9.82 28 339160 24498 70564758
Tenosynovitis 48.88 9.82 5 339183 13971 70575285
Fear 48.62 9.82 213 338975 20598 70568658
Thrombotic microangiopathy 47.90 9.82 13 339175 17835 70571421
Lymphopenia 47.12 9.82 37 339151 27322 70561934
Anaphylactic reaction 46.53 9.82 556 338632 74418 70514838
Osteoporosis 46.44 9.82 103 339085 48804 70540452
Arteriosclerosis 45.72 9.82 179 339009 16459 70572797
Hepatotoxicity 45.68 9.82 88 339100 43898 70545358
Febrile bone marrow aplasia 45.50 9.82 3 339185 11988 70577268
Cytokine release syndrome 45.32 9.82 36 339152 26431 70562825
Shock 45.32 9.82 340 338848 40085 70549171
Glycosylated haemoglobin increased 45.30 9.82 184 339004 17207 70572049
Haematotoxicity 45.06 9.82 6 339182 13668 70575588
Wheezing 44.62 9.82 665 338523 93505 70495751
Immune reconstitution inflammatory syndrome 44.53 9.82 5 339183 12985 70576271
C-reactive protein abnormal 43.83 9.82 73 339115 38506 70550750
Colitis ulcerative 43.57 9.82 59 339129 33864 70555392
Gamma-glutamyltransferase increased 43.17 9.82 113 339075 50572 70538684
Drug reaction with eosinophilia and systemic symptoms 43.09 9.82 138 339050 57875 70531381
Alanine aminotransferase increased 42.99 9.82 474 338714 147006 70442250
Therapeutic product effect decreased 41.95 9.82 459 338729 142559 70446697
Alopecia 41.51 9.82 683 338505 197807 70391449
Muscle spasms 40.87 9.82 995 338193 153051 70436205
Nodular rash 40.86 9.82 23 339165 297 70588959
Product complaint 40.69 9.82 140 339048 12091 70577165
Rheumatoid nodule 40.38 9.82 11 339177 15056 70574200
Coronary artery occlusion 39.96 9.82 155 339033 14190 70575066
Therapy partial responder 39.88 9.82 6 339182 12468 70576788
Inflammation 39.83 9.82 217 338971 78448 70510808
Hepatic cytolysis 39.81 9.82 21 339167 19171 70570085
Tuberculosis 39.50 9.82 11 339177 14837 70574419
Sedation complication 39.48 9.82 8 339180 13402 70575854
Haemophagocytic lymphohistiocytosis 38.47 9.82 23 339165 19589 70569667
Neuroleptic malignant syndrome 37.88 9.82 41 339147 25966 70563290
Blood cholesterol increased 37.88 9.82 474 338714 64130 70525126
Blood sodium decreased 37.78 9.82 266 338922 30732 70558524
Blood electrolytes abnormal 37.76 9.82 45 339143 1769 70587487
Blood urea abnormal 37.68 9.82 38 339150 1235 70588021
Blood glucose decreased 37.25 9.82 220 338968 23939 70565317
Dizziness postural 37.24 9.82 121 339067 10147 70579109
Oedema mouth 37.17 9.82 57 339131 2861 70586395
Haemorrhage intracranial 37.16 9.82 224 338964 24553 70564703
Progressive multifocal leukoencephalopathy 37.04 9.82 23 339165 19191 70570065
Red blood cell sedimentation rate increased 37 9.82 81 339107 38561 70550695
Emotional distress 36.85 9.82 304 338884 36884 70552372
Lymphomatoid papulosis 36.82 9.82 22 339166 320 70588936
Spinal stenosis 36.56 9.82 153 339035 14500 70574756
Device interaction 36.49 9.82 29 339159 684 70588572
Product coating issue 36.45 9.82 13 339175 49 70589207
Pericarditis 36.42 9.82 246 338942 84459 70504797
Blood lactate dehydrogenase increased 35.85 9.82 71 339117 35056 70554200
Oral allergy syndrome 35.85 9.82 13 339175 52 70589204
Pneumonitis 35.76 9.82 137 339051 54460 70534796
Body temperature decreased 35.69 9.82 51 339137 28621 70560635
Product substitution issue 35.57 9.82 179 339009 18334 70570922
Neurotoxicity 35.23 9.82 55 339133 29771 70559485
Aplastic anaemia 35.11 9.82 18 339170 16698 70572558
Eosinophilia 35.02 9.82 89 339099 40230 70549026
Gout 34.51 9.82 208 338980 22798 70566458
Productive cough 34.44 9.82 226 338962 78111 70511145
Nausea 34.38 9.82 4612 334576 847476 69741780
Ill-defined disorder 34.18 9.82 140 339048 54601 70534655
Folliculitis 33.95 9.82 98 339090 42472 70546784
Diarrhoea 33.75 9.82 4257 334931 779084 69810172
Overdose 33.57 9.82 590 338598 169155 70420101
Hyperthermia 33.48 9.82 19 339169 16652 70572604
Graft versus host disease 33.35 9.82 15 339173 15008 70574248
Transplant rejection 33.33 9.82 23 339165 18148 70571108
Pathogen resistance 33.22 9.82 11 339177 13268 70575988
Blood pressure increased 33.05 9.82 1156 338032 187361 70401895
Vision blurred 33.03 9.82 638 338550 94346 70494910
Mydriasis 33.03 9.82 18 339170 16135 70573121
Muscle injury 32.65 9.82 86 339102 38408 70550848
Cognitive disorder 32.62 9.82 165 339023 60791 70528465
Drooling 32.61 9.82 77 339111 5359 70583897
Panniculitis 32.21 9.82 6 339182 10670 70578586
Pharyngeal swelling 31.99 9.82 85 339103 6368 70582888
Pregnancy 31.94 9.82 40 339148 23741 70565515
Orbital myositis 31.79 9.82 16 339172 162 70589094
Suicide attempt 31.70 9.82 236 338952 79274 70509982
Post transplant lymphoproliferative disorder 31.66 9.82 6 339182 10539 70578717
Hyperbilirubinaemia 31.32 9.82 37 339151 22531 70566725
Arteriosclerosis coronary artery 31.30 9.82 157 339031 16058 70573198
Accelerated hypertension 31.13 9.82 25 339163 599 70588657
Laryngeal oedema 30.57 9.82 92 339096 7403 70581853
Stridor 30.56 9.82 72 339116 5004 70584252
Diabetic ketoacidosis 30.37 9.82 256 338932 31256 70558000
Cystitis haemorrhagic 30.24 9.82 3 339185 8590 70580666
Full blood count decreased 30.19 9.82 207 338981 23711 70565545
Pelvic mass 30.18 9.82 32 339156 1104 70588152
Blood pressure systolic abnormal 30.08 9.82 12 339176 12897 70576359
Bronchiectasis 30.03 9.82 20 339168 16077 70573179
Multiple organ dysfunction syndrome 29.96 9.82 353 338835 108162 70481094
Hypoglycaemia 29.87 9.82 625 338563 93739 70495517
Schizophrenia 29.74 9.82 22 339166 16746 70572510
Angina pectoris 29.66 9.82 358 338830 48025 70541231
Pemphigus 29.63 9.82 254 338934 82782 70506474
Epstein-Barr virus infection 29.58 9.82 13 339175 13185 70576071
Dilatation atrial 29.45 9.82 57 339131 3455 70585801
Dysgeusia 29.36 9.82 364 338824 49138 70540118
Mouth swelling 29.14 9.82 73 339115 5276 70583980
Generalised tonic-clonic seizure 28.96 9.82 102 339086 41559 70547697
Myelodysplastic syndrome 28.88 9.82 62 339126 29723 70559533
Arterial occlusive disease 28.77 9.82 92 339096 7650 70581606
Somatic delusion 28.62 9.82 25 339163 675 70588581
Wound 28.50 9.82 318 338870 98414 70490842
Prostate cancer recurrent 28.24 9.82 26 339162 753 70588503
Venoocclusive liver disease 28.24 9.82 8 339180 10670 70578586
Neutropenic sepsis 28.19 9.82 47 339141 24783 70564473
Acute myeloid leukaemia 27.89 9.82 67 339121 30873 70558383
Weight increased 27.53 9.82 916 338272 241415 70347841
Second primary malignancy 27.49 9.82 14 339174 13037 70576219
Drug eruption 27.25 9.82 97 339091 39399 70549857
Ventricular hypertrophy 27.03 9.82 81 339107 6503 70582753
Poisoning deliberate 27.02 9.82 25 339163 17035 70572221
Diabetic neuropathy 26.88 9.82 75 339113 5783 70583473
Drug dependence 26.87 9.82 90 339098 37231 70552025
Polyneuropathy 26.74 9.82 38 339150 21377 70567879
Extrapyramidal disorder 26.73 9.82 36 339152 20714 70568542
Pancreatitis necrotising 26.68 9.82 53 339135 3275 70585981
Upper gastrointestinal haemorrhage 26.44 9.82 285 338903 37192 70552064
Prescribed overdose 26.29 9.82 221 338967 26960 70562296
Aphthous ulcer 26.29 9.82 19 339169 14637 70574619
Lip oedema 26.13 9.82 72 339116 5511 70583745
Body temperature increased 26.06 9.82 100 339088 39734 70549522
Cardiac arrest 26.02 9.82 972 338216 158862 70430394
Similar reaction on previous exposure to drug 25.85 9.82 12 339176 100 70589156
Fall 25.64 9.82 2461 336727 441635 70147621
Oral herpes 25.45 9.82 48 339140 24138 70565118
Atrioventricular block first degree 25.41 9.82 117 339071 11556 70577700
Haemodialysis 25.41 9.82 156 339032 17210 70572046
Blood parathyroid hormone decreased 25.32 9.82 6 339182 9018 70580238
Erectile dysfunction 25.26 9.82 130 339058 13432 70575824
Pneumonia aspiration 25.25 9.82 184 339004 62105 70527151
Diabetic foot infection 25.24 9.82 24 339164 725 70588531
Caesarean section 25.13 9.82 12 339176 11595 70577661
Myalgia 24.97 9.82 1011 338177 166881 70422375
Facet joint syndrome 24.90 9.82 75 339113 6038 70583218
Blood pressure systolic increased 24.76 9.82 166 339022 57093 70532163
Feeling abnormal 24.75 9.82 872 338316 141447 70447809
Rash maculo-papular 24.73 9.82 141 339047 50404 70538852
Atrioventricular block second degree 24.69 9.82 80 339108 6698 70582558
Pulmonary tuberculosis 24.56 9.82 4 339184 7841 70581415
Cough 24.42 9.82 1839 337349 323538 70265718
Aplasia 24.33 9.82 3 339185 7248 70582008
Bone erosion 24.31 9.82 22 339166 15151 70574105
Transaminases increased 24.19 9.82 129 339059 46889 70542367
Gangrene 24.14 9.82 91 339097 8218 70581038
Psoriasis 24.09 9.82 629 338559 97804 70491452
Unevaluable event 24.01 9.82 366 338822 51697 70537559
Ulnar nerve palsy 23.88 9.82 7 339181 11 70589245
Potassium wasting nephropathy 23.85 9.82 13 339175 157 70589099
Unintentional medical device removal 23.78 9.82 3 339185 7121 70582135
Mitral valve incompetence 23.61 9.82 213 338975 26515 70562741
Memory impairment 23.55 9.82 595 338593 92046 70497210
Rotator cuff repair 23.54 9.82 34 339154 1617 70587639
Oedema genital 23.45 9.82 19 339169 461 70588795
Enterocolitis 23.36 9.82 17 339171 13049 70576207
Factor VII deficiency 23.33 9.82 8 339180 26 70589230
Blood loss anaemia 23.23 9.82 133 339055 14308 70574948
Anti-cyclic citrullinated peptide antibody positive 23.15 9.82 219 338969 69966 70519290
Stent placement 23.13 9.82 73 339115 6028 70583228
Aspartate aminotransferase increased 23.02 9.82 448 338740 126530 70462726
Herpes zoster 22.86 9.82 279 338909 84956 70504300
Platelet count decreased 22.83 9.82 663 338525 177559 70411697
Ageusia 22.69 9.82 135 339053 14727 70574529
Azotaemia 22.60 9.82 85 339103 7668 70581588
Peripheral vascular disorder 22.52 9.82 84 339104 7548 70581708
Osteonecrosis of jaw 22.51 9.82 110 339078 40892 70548364
Cytomegalovirus viraemia 22.50 9.82 14 339174 11671 70577585
Sleep disorder due to a general medical condition 22.42 9.82 11 339177 10465 70578791
Non-cardiac chest pain 22.39 9.82 94 339094 8921 70580335
Cardiac failure 22.36 9.82 519 338669 143022 70446234
Chronic graft versus host disease 22.24 9.82 3 339185 6767 70582489
Pulmonary renal syndrome 22.11 9.82 20 339168 566 70588690
Uveitis 22.07 9.82 23 339165 14822 70574434
Unresponsive to stimuli 22.03 9.82 360 338828 51571 70537685
Electrocardiogram T wave abnormal 22.02 9.82 50 339138 3392 70585864
Hepatic ischaemia 22.00 9.82 26 339162 1013 70588243
Hypogammaglobulinaemia 21.98 9.82 14 339174 11524 70577732
Sight disability 21.89 9.82 11 339177 111 70589145
Osmolar gap increased 21.87 9.82 8 339180 33 70589223
Acne 21.83 9.82 55 339133 24934 70564322
Pulmonary arterial hypertension 21.80 9.82 82 339106 32773 70556483
Hypoaesthesia 21.77 9.82 921 338267 152818 70436438
Device related infection 21.57 9.82 80 339108 32105 70557151
No reaction on previous exposure to drug 21.54 9.82 14 339174 238 70589018
Infective pulmonary exacerbation of cystic fibrosis 21.50 9.82 16 339172 12142 70577114
Rectal haemorrhage 21.48 9.82 438 338750 65393 70523863
Metabolic acidosis 21.48 9.82 486 338702 73860 70515396
Acute coronary syndrome 21.45 9.82 167 339021 19912 70569344
Musculoskeletal stiffness 21.44 9.82 540 338648 147220 70442036
Gastric cancer 21.40 9.82 8 339180 8947 70580309
Poor venous access 21.37 9.82 24 339164 14947 70574309
Impaired healing 21.28 9.82 240 338948 74134 70515122
Torsade de pointes 21.23 9.82 154 339034 17962 70571294
Drug-induced liver injury 21.22 9.82 169 339019 55944 70533312
Essential hypertension 21.14 9.82 66 339122 5418 70583838
Peripheral venous disease 21 9.82 104 339084 10583 70578673
Intentional dose omission 20.99 9.82 77 339111 6864 70582392
Enthesopathy 20.96 9.82 13 339175 10856 70578400
Rhabdomyolysis 20.91 9.82 603 338585 95157 70494099
Suspected suicide attempt 20.85 9.82 15 339173 303 70588953
Speech disorder 20.85 9.82 349 338839 50231 70539025
Irritable bowel syndrome 20.71 9.82 150 339038 50700 70538556
Dermatitis exfoliative generalised 20.70 9.82 3 339185 6411 70582845
Muscle relaxant therapy 20.67 9.82 12 339176 165 70589091
Pulmonary fibrosis 20.64 9.82 89 339099 34221 70555035
Pseudomonas infection 20.61 9.82 37 339151 18957 70570299
Raynaud's phenomenon 20.60 9.82 25 339163 1002 70588254
Encephalitis 20.25 9.82 21 339167 13564 70575692
Paraesthesia 20.19 9.82 870 338318 144667 70444589
Ovarian cyst 20.17 9.82 16 339172 11756 70577500
Immunodeficiency 20.14 9.82 33 339155 17522 70571734
Chronic obstructive pulmonary disease 20.13 9.82 500 338688 77141 70512115
Cardiac murmur 20.11 9.82 113 339075 12073 70577183
Substance abuse 20.06 9.82 11 339177 9826 70579430
Product monitoring error 20.04 9.82 4 339184 6772 70582484
Diverticulum 20.03 9.82 123 339065 13570 70575686
Lung disorder 19.97 9.82 224 338964 69260 70519996
Dystonia 19.96 9.82 40 339148 19666 70569590
Foetal death 19.95 9.82 3 339185 6236 70583020
Dialysis 19.86 9.82 147 339041 17255 70572001
Thermohypoaesthesia 19.81 9.82 10 339178 102 70589154
Conjunctivitis 19.63 9.82 50 339138 22586 70566670
Penile swelling 19.55 9.82 19 339169 590 70588666
Systemic infection 19.54 9.82 4 339184 6653 70582603
Colitis ischaemic 19.44 9.82 125 339063 14012 70575244
Premature labour 19.37 9.82 7 339181 7993 70581263
Breast cancer stage I 19.36 9.82 3 339185 6099 70583157
Inappropriate schedule of product administration 19.34 9.82 380 338808 107175 70482081
Candida infection 19.20 9.82 92 339096 34381 70554875
Electrocardiogram change 19.14 9.82 26 339162 1167 70588089
Anal abscess 19.10 9.82 8 339180 8350 70580906
Lip dry 19.07 9.82 95 339093 9690 70579566
Lethargy 19.03 9.82 483 338705 74767 70514489
Carcinoid tumour of the gastrointestinal tract 18.99 9.82 9 339179 79 70589177
Mouth ulceration 18.94 9.82 92 339096 34257 70554999
Concomitant disease aggravated 18.89 9.82 18 339170 12096 70577160
Pulseless electrical activity 18.89 9.82 118 339070 13097 70576159
Oral candidiasis 18.78 9.82 59 339129 24893 70564363
Hypoaldosteronism 18.76 9.82 15 339173 357 70588899
Withdrawal hypertension 18.72 9.82 15 339173 358 70588898
Graft versus host disease in gastrointestinal tract 18.68 9.82 3 339185 5941 70583315
Spur cell anaemia 18.61 9.82 9 339179 83 70589173
Ankylosing spondylitis 18.52 9.82 17 339171 11629 70577627
Adenovirus infection 18.47 9.82 7 339181 7761 70581495
Amnesia 18.36 9.82 351 338837 51804 70537452
Drug use disorder 18.31 9.82 8 339180 8143 70581113
Acquired acrodermatitis enteropathica 18.30 9.82 5 339183 5 70589251
Eye swelling 18.28 9.82 183 339005 23431 70565825
Oropharyngeal swelling 18.17 9.82 26 339162 1226 70588030
Blood glucose abnormal 18.07 9.82 92 339096 9465 70579791
Eosinophil count increased 18.05 9.82 28 339160 15194 70574062
Alanine aminotransferase abnormal 17.96 9.82 8 339180 8051 70581205
Intentional product use issue 17.71 9.82 438 338750 119704 70469552
Migraine 17.69 9.82 241 338947 71997 70517259
Body height decreased 17.68 9.82 79 339109 7704 70581552
Respiratory disorder 17.63 9.82 112 339076 39011 70550245
Miosis 17.63 9.82 25 339163 14076 70575180
Lid lag 17.51 9.82 8 339180 64 70589192
Toxic epidermal necrolysis 17.44 9.82 114 339074 39443 70549813
Urethral prolapse 17.39 9.82 4 339184 0 70589256
Abnormal dreams 17.29 9.82 98 339090 10505 70578751
Myxoedema coma 17.16 9.82 19 339169 689 70588567
Cholelithiasis 17.15 9.82 320 338868 47020 70542236
Benign gastrointestinal neoplasm 17.13 9.82 10 339178 139 70589117
Refusal of treatment by patient 17.05 9.82 83 339105 8387 70580869
Sinusitis 17.04 9.82 649 338539 168546 70420710
Renal artery stenosis 17.04 9.82 44 339144 3240 70586016
Dysphonia 16.90 9.82 335 338853 49765 70539491
Carotid artery stenosis 16.79 9.82 81 339107 8155 70581101
Posterior reversible encephalopathy syndrome 16.79 9.82 60 339128 24342 70564914
Oedema 16.63 9.82 629 338559 102952 70486304
Seizure 16.55 9.82 689 338499 177273 70411983
Colorectal cancer 16.52 9.82 10 339178 8460 70580796
Grip strength decreased 16.51 9.82 130 339058 15555 70573701
Hyperammonaemia 16.40 9.82 15 339173 10278 70578978
Hyponatraemia 16.36 9.82 929 338259 159158 70430098
Respiratory tract infection 16.35 9.82 127 339061 42271 70546985
Glomerulonephritis membranous 16.25 9.82 28 339160 1551 70587705
BK virus infection 16.19 9.82 9 339179 7980 70581276
Acute respiratory distress syndrome 16.18 9.82 123 339065 41131 70548125
Renal tubular acidosis 16.18 9.82 44 339144 3342 70585914
Hepatitis B reactivation 16.18 9.82 3 339185 5352 70583904
Hepatocellular carcinoma 16.12 9.82 15 339173 10193 70579063
Depression 16.00 9.82 1131 338057 197843 70391413
Therapeutic response decreased 15.80 9.82 191 338997 58262 70530994
Device expulsion 15.77 9.82 54 339134 22192 70567064
Pulmonary toxicity 15.75 9.82 17 339171 10781 70578475
Paradoxical drug reaction 15.74 9.82 6 339182 6630 70582626
Tumour lysis syndrome 15.73 9.82 51 339137 21309 70567947
Pollakiuria 15.73 9.82 236 338952 33225 70556031
Macroglossia 15.70 9.82 23 339165 1108 70588148
Abortion induced 15.70 9.82 6 339182 6619 70582637
Cardiomegaly 15.65 9.82 183 339005 24362 70564894
Peripheral sensory neuropathy 15.61 9.82 21 339167 12089 70577167
Eczema 15.59 9.82 96 339092 33685 70555571
Treatment noncompliance 15.57 9.82 311 338877 46263 70542993
Tonsillitis 15.51 9.82 5 339183 6135 70583121
Dyspnoea 15.45 9.82 4023 335165 766037 69823219
Therapeutic response unexpected 15.45 9.82 144 339044 18087 70571169
Blood pressure diastolic decreased 15.43 9.82 67 339121 25713 70563543
Foot deformity 15.43 9.82 49 339139 20606 70568650
Facial nerve disorder 15.42 9.82 18 339170 692 70588564
Glossodynia 15.41 9.82 306 338882 86181 70503075
Immune-mediated myositis 15.40 9.82 41 339147 3075 70586181
Charles Bonnet syndrome 15.40 9.82 5 339183 13 70589243
Oropharyngeal pain 15.34 9.82 347 338841 95963 70493293
Electrocardiogram QT prolonged 15.34 9.82 294 338894 83223 70506033
Hepatitis acute 15.33 9.82 27 339161 13935 70575321
Graft versus host disease in skin 15.30 9.82 4 339184 5626 70583630
BRASH syndrome 15.28 9.82 17 339171 620 70588636
Diffuse large B-cell lymphoma 15.27 9.82 25 339163 13277 70575979
Expired product administered 15.26 9.82 66 339122 6347 70582909
Tricuspid valve incompetence 15.23 9.82 141 339047 17676 70571580
Cytopenia 15.23 9.82 38 339150 17285 70571971
Rheumatic fever 15.22 9.82 140 339048 17520 70571736
Pre-eclampsia 15.16 9.82 6 339182 6479 70582777
Chronic sinusitis 15.10 9.82 11 339177 8440 70580816
Nephrogenic systemic fibrosis 14.95 9.82 63 339125 5989 70583267
Fistula 14.93 9.82 18 339170 10863 70578393
Haemolysis 14.92 9.82 20 339168 11531 70577725
Ileus paralytic 14.89 9.82 12 339176 8749 70580507
Endometriosis male 14.88 9.82 5 339183 15 70589241
Gastrointestinal toxicity 14.85 9.82 6 339182 6399 70582857
Respiratory distress 14.78 9.82 354 338834 54296 70534960
Fatigue 14.77 9.82 4286 334902 820033 69769223
Tachycardia 14.70 9.82 614 338574 157932 70431324
Dry mouth 14.65 9.82 441 338747 70016 70519240
Alcoholic ketoacidosis 14.64 9.82 5 339183 16 70589240
Neutrophil count increased 14.64 9.82 72 339116 26723 70562533
Hereditary angioedema with normal C1 esterase inhibitor 14.64 9.82 4 339184 4 70589252
Diverticulum intestinal haemorrhagic 14.56 9.82 43 339145 3424 70585832
Retching 14.45 9.82 128 339060 15851 70573405
End stage renal disease 14.43 9.82 97 339091 11036 70578220
Device dislocation 14.40 9.82 57 339131 22450 70566806
Anaemia 14.40 9.82 1699 337489 401724 70187532
Fluid intake reduced 14.35 9.82 59 339129 5548 70583708
Hypertensive urgency 14.34 9.82 13 339175 369 70588887
Fear of injection 14.29 9.82 7 339181 6665 70582591
Hypertransaminasaemia 14.29 9.82 13 339175 8930 70580326
Acute lymphocytic leukaemia recurrent 14.28 9.82 3 339185 4901 70584355
Skin necrosis 14.12 9.82 36 339152 16255 70573001
Hypertensive heart disease 14.07 9.82 46 339142 3870 70585386
Enlarged uvula 13.94 9.82 13 339175 383 70588873
Blood pressure abnormal 13.89 9.82 124 339064 15390 70573866
Penile contusion 13.84 9.82 8 339180 109 70589147
Atrioventricular block 13.82 9.82 106 339082 12582 70576674
Gastric ulcer helicobacter 13.79 9.82 5 339183 20 70589236
Blood glucose fluctuation 13.78 9.82 63 339125 6204 70583052
Dysarthria 13.77 9.82 393 338795 61920 70527336
Occult blood positive 13.75 9.82 64 339124 6349 70582907
Product physical issue 13.68 9.82 44 339144 3670 70585586
Blood immunoglobulin E increased 13.62 9.82 3 339185 4741 70584515
Sepsis 13.59 9.82 996 338192 243549 70345707
Laryngotracheal oedema 13.58 9.82 6 339182 44 70589212
Blood bilirubin increased 13.56 9.82 203 338985 59698 70529558
Encephalomalacia 13.50 9.82 22 339166 1164 70588092
Pancreatitis haemorrhagic 13.40 9.82 17 339171 713 70588543
Cerebral thrombosis 13.40 9.82 32 339156 2244 70587012
Liver abscess 13.39 9.82 5 339183 5594 70583662
Skin toxicity 13.35 9.82 9 339179 7189 70582067
Neutropenic colitis 13.21 9.82 4 339184 5110 70584146
Pseudomembranous colitis 13.20 9.82 4 339184 5107 70584149
Vomiting 13.19 9.82 3113 336075 589998 69999258
Nodule 13.15 9.82 50 339138 19919 70569337
Pulse absent 13.14 9.82 83 339105 9247 70580009
Drug dispensed to wrong patient 13.14 9.82 15 339173 563 70588693
Fracture 13.09 9.82 50 339138 19894 70569362
Labelled drug-drug interaction medication error 13.08 9.82 65 339123 24062 70565194
Fear of eating 13.08 9.82 13 339175 415 70588841
Prostate examination abnormal 13.08 9.82 9 339179 169 70589087
Therapeutic response shortened 13.06 9.82 26 339162 12812 70576444
Vitreous floaters 13.00 9.82 65 339123 6639 70582617
Herpes simplex 12.99 9.82 21 339167 11211 70578045
Appendicitis 12.99 9.82 39 339149 16694 70572562
Hypertensive crisis 12.91 9.82 145 339043 19117 70570139
Intestinal obstruction 12.87 9.82 121 339067 38704 70550552
Nodal rhythm 12.86 9.82 37 339151 2904 70586352
Drug tolerance 12.85 9.82 10 339178 7418 70581838
Sleep attacks 12.81 9.82 9 339179 175 70589081
Joint effusion 12.80 9.82 35 339153 15442 70573814
Shock haemorrhagic 12.80 9.82 44 339144 18062 70571194
Endotracheal intubation complication 12.77 9.82 17 339171 748 70588508
Brain oedema 12.75 9.82 63 339125 23355 70565901
Mixed liver injury 12.72 9.82 7 339181 6242 70583014
Uvulitis 12.72 9.82 4 339184 9 70589247
Creatinine renal clearance decreased 12.71 9.82 41 339147 17159 70572097
Foetal disorder 12.67 9.82 8 339180 129 70589127
Acute generalised exanthematous pustulosis 12.60 9.82 35 339153 15362 70573894
Bundle branch block left 12.53 9.82 89 339099 10310 70578946
Granuloma 12.52 9.82 11 339177 7684 70581572
Hypoglycaemic unconsciousness 12.50 9.82 21 339167 1139 70588117
Faecal calprotectin increased 12.47 9.82 3 339185 4462 70584794
Coronary artery surgery 12.46 9.82 9 339179 183 70589073
Sinus bradycardia 12.45 9.82 170 339018 23453 70565803
Respiratory tract oedema 12.45 9.82 17 339171 767 70588489
Pain 12.43 9.82 2739 336449 626077 69963179
Liver injury 12.40 9.82 270 338918 40765 70548491
Lymphoproliferative disorder 12.34 9.82 5 339183 5324 70583932
Lacunar infarction 12.33 9.82 57 339131 5639 70583617
Asphyxia 12.28 9.82 19 339169 10323 70578933
Skin exfoliation 12.26 9.82 312 338876 48314 70540942
Apathy 12.21 9.82 24 339164 11884 70577372
Sinus node dysfunction 12.18 9.82 67 339121 7102 70582154
Thrombosis 12.12 9.82 458 338730 74947 70514309
Pharyngitis 12.12 9.82 53 339135 20298 70568958
Oedema peripheral 12.11 9.82 1257 337931 226834 70362422
Adjustment disorder with depressed mood 12.06 9.82 46 339142 4177 70585079
Immunosuppressant drug level increased 12.04 9.82 12 339176 7895 70581361
Dyspnoea at rest 12.02 9.82 9 339179 6810 70582446
Angiotensin converting enzyme inhibitor foetopathy 12.02 9.82 5 339183 31 70589225
Exercise tolerance increased 12.02 9.82 5 339183 31 70589225
Ear pain 11.94 9.82 80 339108 27519 70561737
Bone density decreased 11.87 9.82 23 339165 11451 70577805
Loss of personal independence in daily activities 11.86 9.82 312 338876 84598 70504658
Neurological decompensation 11.79 9.82 4 339184 4752 70584504
Parkinsonism 11.70 9.82 36 339152 15289 70573967
Epiglottic oedema 11.70 9.82 10 339178 262 70588994
Skin induration 11.63 9.82 46 339142 4249 70585007
Pseudomonal sepsis 11.57 9.82 6 339182 5531 70583725
Hospice care 11.56 9.82 73 339115 8132 70581124
Palatal swelling 11.54 9.82 8 339180 152 70589104
Eosinophilic oesophagitis 11.45 9.82 13 339175 485 70588771
Adrenal insufficiency 11.42 9.82 72 339116 25123 70564133
Transient psychosis 11.41 9.82 6 339182 67 70589189
Clonus 11.41 9.82 8 339180 6260 70582996
Body temperature 11.39 9.82 5 339183 36 70589220
Gait disturbance 11.28 9.82 1030 338158 184076 70405180
Pneumopericardium 11.28 9.82 8 339180 158 70589098
Small intestinal ulcer haemorrhage 11.25 9.82 7 339181 110 70589146
Albumin urine present 11.24 9.82 15 339173 662 70588594
Erythema multiforme 11.21 9.82 41 339147 16523 70572733
Red cell distribution width increased 11.21 9.82 31 339157 13626 70575630
Hepatic encephalopathy 11.20 9.82 61 339127 22057 70567199
Multiple injuries 11.18 9.82 39 339149 3392 70585864
Metastases to bone 11.17 9.82 62 339126 22314 70566942
Depressed mood 11.16 9.82 145 339043 43675 70545581
Malaise 11.13 9.82 1860 337328 431072 70158184
Deep vein thrombosis 11.07 9.82 643 338545 110399 70478857
High density lipoprotein decreased 11.06 9.82 44 339144 4075 70585181
Erythema marginatum 11.03 9.82 4 339184 16 70589240
Product prescribing error 11.02 9.82 126 339062 38826 70550430
Device difficult to use 11.01 9.82 22 339166 10827 70578429
Pulse volume decreased 10.98 9.82 3 339185 3 70589253
Product solubility abnormal 10.96 9.82 17 339171 862 70588394
Skin odour abnormal 10.95 9.82 27 339161 1932 70587324
Drug specific antibody present 10.95 9.82 7 339181 5751 70583505
Transcription medication error 10.95 9.82 11 339177 356 70588900
Disturbance in social behaviour 10.84 9.82 3 339185 4064 70585192
Carotid artery occlusion 10.83 9.82 44 339144 4115 70585141
Prostatic specific antigen increased 10.82 9.82 80 339108 9386 70579870
Cataract nuclear 10.77 9.82 18 339170 972 70588284
Ludwig angina 10.75 9.82 9 339179 229 70589027
Bradykinesia 10.74 9.82 12 339176 7490 70581766
Bicytopenia 10.68 9.82 3 339185 4025 70585231
Fungal infection 10.68 9.82 121 339067 37346 70551910
Lymphoma 10.65 9.82 38 339150 15424 70573832
Gastrointestinal vascular malformation 10.64 9.82 5 339183 43 70589213
Peripheral swelling 10.63 9.82 980 338208 235583 70353673
Enterococcal infection 10.61 9.82 35 339153 14547 70574709
COVID-19 10.57 9.82 406 338782 105351 70483905
Dilatation ventricular 10.56 9.82 42 339146 3889 70585367
Anxiety 10.55 9.82 1206 337982 219124 70370132
Rhinovirus infection 10.51 9.82 10 339178 6723 70582533
Conjunctival scar 10.50 9.82 8 339180 177 70589079
Hyperuricaemia 10.49 9.82 23 339165 10943 70578313
Infusion site pain 10.45 9.82 25 339163 11539 70577717
Cerebellar syndrome 10.45 9.82 6 339182 5225 70584031
Subileus 10.44 9.82 6 339182 5221 70584035
Extra dose administered 10.41 9.82 65 339123 7212 70582044
Lower gastrointestinal haemorrhage 10.41 9.82 112 339076 14608 70574648
Nystagmus 10.35 9.82 18 339170 9337 70579919
Hypoaesthesia oral 10.34 9.82 97 339091 12203 70577053
Electrocardiogram ST-T change 10.34 9.82 23 339165 1539 70587717
Circulatory collapse 10.33 9.82 114 339074 35360 70553896
Vitritis infective 10.32 9.82 4 339184 20 70589236
Visceral oedema 10.32 9.82 4 339184 20 70589236
Cystitis 10.31 9.82 160 339028 46781 70542475
Contrast media reaction 10.28 9.82 26 339162 1890 70587366
Kidney transplant rejection 10.28 9.82 20 339168 9941 70579315
Gait inability 10.27 9.82 297 338891 46878 70542378
Toe amputation 10.27 9.82 39 339149 3534 70585722
Complications of transplanted kidney 10.25 9.82 8 339180 5926 70583330
Lichen planus 10.23 9.82 31 339157 2504 70586752
Pain in jaw 10.22 9.82 143 339045 42526 70546730
Muscular weakness 10.21 9.82 781 338407 137555 70451701
Carcinoid tumour of the stomach 10.16 9.82 8 339180 186 70589070
Retroperitoneal oedema 10.16 9.82 4 339184 21 70589235
Toxic shock syndrome staphylococcal 10.12 9.82 3 339185 5 70589251
Eyelid margin crusting 10.12 9.82 16 339172 825 70588431
Peripancreatic fluid collection 10.08 9.82 5 339183 49 70589207
Impaired driving ability 10.07 9.82 48 339140 4809 70584447
Transfusion-related circulatory overload 10.07 9.82 10 339178 319 70588937
Lacunar stroke 10.07 9.82 10 339178 319 70588937
Cytomegalovirus test positive 10.06 9.82 7 339181 5501 70583755
Peripheral artery stenosis 10.05 9.82 20 339168 1237 70588019
Metastases to lymph nodes 10.02 9.82 18 339170 9220 70580036
Hypoventilation 10.01 9.82 10 339178 6572 70582684
Burning sensation 9.96 9.82 327 338861 52543 70536713
Plasma cell myeloma 9.95 9.82 270 338918 72931 70516325
Psychomotor skills impaired 9.95 9.82 4 339184 4280 70584976
Transplant dysfunction 9.94 9.82 11 339177 6898 70582358
Cystic fibrosis 9.94 9.82 4 339184 4277 70584979
Chromaturia 9.94 9.82 163 339025 23365 70565891
Monocyte count increased 9.94 9.82 18 339170 9191 70580065
Hepatic failure 9.93 9.82 205 338983 57420 70531836
Pallor 9.92 9.82 137 339051 40837 70548419
Pseudolymphoma 9.92 9.82 18 339170 1039 70588217
Hypogeusia 9.88 9.82 23 339165 1586 70587670
Petit mal epilepsy 9.84 9.82 7 339181 5437 70583819

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C09AA03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, PLAIN
ACE inhibitors, plain
ATC C09BA03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and diuretics
ATC C09BB03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
ATC C10BX07 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
CHEBI has role CHEBI:35674 antihypertensive drugs
MeSH PA D000806 Angiotensin-Converting Enzyme Inhibitors
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002316 Cardiotonic Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011480 Protease Inhibitors
MeSH PA D020011 Protective Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Myocardial infarction indication 22298006 DOID:5844
Hypertensive disorder indication 38341003 DOID:10763
Chronic heart failure indication 48447003
Superficial Ocular Infection indication
Diabetic retinopathy off-label use 4855003 DOID:8947
Atrial fibrillation off-label use 49436004 DOID:0060224
Blepharoconjunctivitis off-label use 68659002 DOID:2456
Dacryocystitis off-label use 85777005 DOID:9938
Corneal ulcer off-label use 91514001 DOID:8463
Diabetic renal disease off-label use 127013003
Bacterial conjunctivitis off-label use 128350005 DOID:9700
Acute scleroderma renal crisis off-label use 236503001
Meibomianitis off-label use 309779001
Infective blepharitis off-label use 312219000
Bacterial keratitis off-label use 314557000
Diastolic heart failure off-label use 418304008 DOID:9775
Nondiabetic Proteinuric Nephropathy off-label use
Migraine Prevention off-label use
Anuria contraindication 2472002 DOID:2983
Hypercholesterolemia contraindication 13644009
Hyperkalemia contraindication 14140009
Jaundice contraindication 18165001
Secondary angle-closure glaucoma contraindication 21571006
Hypovolemia contraindication 28560003
Acute cerebrovascular insufficiency contraindication 29322000
Dehydration contraindication 34095006
Hyperuricemia contraindication 35885006 DOID:1920
Immunosuppression contraindication 38013005
Angioedema contraindication 41291007 DOID:1558
Hypokalemia contraindication 43339004
Low blood pressure contraindication 45007003
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Aortic valve stenosis contraindication 60573004 DOID:1712
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypochloremic alkalosis contraindication 70134007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Hereditary angioneurotic edema contraindication 82966003 DOID:14735
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Disorder of connective tissue contraindication 105969002 DOID:65
Liver function tests abnormal contraindication 166603001
Hypomagnesemia contraindication 190855004
Acute hepatic failure contraindication 197270009
Acute pancreatitis contraindication 197456007 DOID:2913
Hypertrophic cardiomyopathy contraindication 233873004 DOID:11984
Disease of liver contraindication 235856003 DOID:409
Disorder of electrolytes contraindication 237840007
Neonatal hyperbilirubinemia contraindication 281610001
Pregnancy, function contraindication 289908002
Renal artery stenosis contraindication 302233006
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Azotemia contraindication 445009001
Hemodialysis with High-Flux Membrane contraindication
Intestinal Angioedema contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.18 acidic
pKa2 3.18 acidic
pKa3 11.0 Basic
pKa4 6.95 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 10039800 Nov. 6, 2035 ACUTE MYOCARDIAL INFARCTION
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 10039800 Nov. 6, 2035 METHOD OF TREATING HYPERTENSION
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 10039800 Nov. 6, 2035 METHOD OF TREATMENT OF HEART FAILURE
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 10039800 Nov. 6, 2035 REDUCTION OF MORTALITY IN ACUTE MYOCARDIAL INFARCTION
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 10039800 Nov. 6, 2035 TREATMENT OF HEART FAILURE
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 10039800 Nov. 6, 2035 TREATMENT OF HYPERTENSION
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 10039800 Nov. 6, 2035 TREATMENT OF MYOCARDIAL INFARCTION
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 10406199 Nov. 6, 2035 ACUTE MYOCARDIAL INFARCTION
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 10406199 Nov. 6, 2035 METHOD OF TREATING HYPERTENSION
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 10406199 Nov. 6, 2035 METHOD OF TREATMENT OF HEART FAILURE
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 10406199 Nov. 6, 2035 REDUCTION OF MORTALITY IN ACUTE MYOCARDIAL INFARCTION
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 10406199 Nov. 6, 2035 TREATMENT OF HEART FAILURE
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 10406199 Nov. 6, 2035 TREATMENT OF HYPERTENSION
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 10406199 Nov. 6, 2035 TREATMENT OF MYOCARDIAL INFARCTION
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 9616096 Nov. 6, 2035 ACUTE MYOCARDIAL INFARCTION
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 9616096 Nov. 6, 2035 METHOD OF TREATING HYPERTENSION
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 9616096 Nov. 6, 2035 METHOD OF TREATMENT OF HEART FAILURE
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 9616096 Nov. 6, 2035 REDUCTION OF MORTALITY IN ACUTE MYOCARDIAL INFARCTION
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 9616096 Nov. 6, 2035 TREATMENT OF HEART FAILURE
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 9616096 Nov. 6, 2035 TREATMENT OF HYPERTENSION
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 9616096 Nov. 6, 2035 TREATMENT OF MYOCARDIAL INFARCTION

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Angiotensin-converting enzyme Enzyme INHIBITOR IC50 8.92 WOMBAT-PK CHEMBL
Angiotensin-converting enzyme Enzyme Ki 7.29 CHEMBL

External reference:

IDSource
4019380 VUID
N0000147537 NUI
D00362 KEGG_DRUG
83915-83-7 SECONDARY_CAS_RN
4019380 VANDF
C0065374 UMLSCUI
CHEBI:6503 CHEBI
LPR PDB_CHEM_ID
CHEMBL1237 ChEMBL_ID
CHEMBL1729579 ChEMBL_ID
CHEMBL419213 ChEMBL_ID
D017706 MESH_DESCRIPTOR_UI
DB00722 DRUGBANK_ID
5362119 PUBCHEM_CID
6360 IUPHAR_LIGAND_ID
E7199S1YWR UNII
29046 RXNORM
31907 MMSL
44066 MMSL
4985 MMSL
d00732 MMSL
000658 NDDF
108575001 SNOMEDCT_US
341000220102 SNOMEDCT_US
386873009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Lisinopril with Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0143-1262 TABLET 10 mg ORAL ANDA 24 sections
Lisinopril with Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0143-1262 TABLET 10 mg ORAL ANDA 24 sections
Lisinopril with Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0143-1263 TABLET 20 mg ORAL ANDA 24 sections
Lisinopril with Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0143-1263 TABLET 20 mg ORAL ANDA 24 sections
Lisinopril with Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0143-1264 TABLET 20 mg ORAL ANDA 24 sections
Lisinopril with Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0143-1264 TABLET 20 mg ORAL ANDA 24 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0143-9713 TABLET 20 mg ORAL ANDA 26 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0143-9714 TABLET 10 mg ORAL ANDA 26 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0143-9715 TABLET 5 mg ORAL ANDA 26 sections
lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0185-0025 TABLET 2.50 mg ORAL ANDA 25 sections
lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0185-0101 TABLET 10 mg ORAL ANDA 25 sections
lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0185-0102 TABLET 20 mg ORAL ANDA 25 sections
lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0185-0103 TABLET 30 mg ORAL ANDA 25 sections
lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0185-0104 TABLET 40 mg ORAL ANDA 25 sections
Lisinopril and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0185-0152 TABLET 20 mg ORAL ANDA 22 sections
Lisinopril and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0185-0173 TABLET 20 mg ORAL ANDA 22 sections
lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0185-0602 TABLET 2.50 mg ORAL ANDA 25 sections
lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0185-0605 TABLET 5 mg ORAL ANDA 25 sections
lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0185-0610 TABLET 10 mg ORAL ANDA 25 sections
lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0185-0620 TABLET 20 mg ORAL ANDA 25 sections
lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0185-0630 TABLET 30 mg ORAL ANDA 25 sections
lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0185-0640 TABLET 40 mg ORAL ANDA 25 sections
lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0185-5400 TABLET 5 mg ORAL ANDA 25 sections
Lisinopril and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0185-7100 TABLET 10 mg ORAL ANDA 22 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0440-7674 TABLET 5 mg ORAL ANDA 21 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0591-0405 TABLET 2.50 mg ORAL ANDA 26 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0591-0405 TABLET 2.50 mg ORAL ANDA 26 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0591-0406 TABLET 5 mg ORAL ANDA 26 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0591-0406 TABLET 5 mg ORAL ANDA 26 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0591-0407 TABLET 10 mg ORAL ANDA 26 sections