linezolid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| oxazolidinone antibacterials | 1584 | 165800-03-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An oxazolidinone and acetamide derived ANTI-BACTERIAL AGENT and PROTEIN SYNTHESIS INHIBITOR that is used in the treatment of GRAM-POSITIVE BACTERIAL INFECTIONS of the skin and respiratory tract.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 1.20 | g | O |
| 1.20 | g | P |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 8 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 30 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 50.82 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 99 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.58 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 1.80 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.69 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 4.50 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| April 18, 2000 | FDA | PHARMACIA AND UPJOHN |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Lactic acidosis | 767.65 | 17.20 | 351 | 24911 | 37936 | 63425824 |
| Thrombocytopenia | 709.94 | 17.20 | 540 | 24722 | 150617 | 63313143 |
| Serotonin syndrome | 609.67 | 17.20 | 274 | 24988 | 28408 | 63435352 |
| Anaemia | 354.33 | 17.20 | 505 | 24757 | 292925 | 63170835 |
| Drug resistance | 345.67 | 17.20 | 173 | 25089 | 22760 | 63441000 |
| Pathogen resistance | 299.52 | 17.20 | 108 | 25154 | 6290 | 63457470 |
| Multiple organ dysfunction syndrome | 270.45 | 17.20 | 205 | 25057 | 56547 | 63407213 |
| Pancytopenia | 239.98 | 17.20 | 241 | 25021 | 96692 | 63367068 |
| Electrocardiogram QT prolonged | 225.67 | 17.20 | 188 | 25074 | 59342 | 63404418 |
| Drug interaction | 222.89 | 17.20 | 357 | 24905 | 228774 | 63234986 |
| Neuropathy peripheral | 209.89 | 17.20 | 242 | 25020 | 113425 | 63350335 |
| Septic shock | 199.48 | 17.20 | 184 | 25078 | 66445 | 63397315 |
| Optic neuropathy | 173.75 | 17.20 | 54 | 25208 | 1978 | 63461782 |
| Fatigue | 151.57 | 17.20 | 83 | 25179 | 887945 | 62575815 |
| Pain | 140.30 | 17.20 | 60 | 25202 | 740568 | 62723192 |
| Myelosuppression | 138.66 | 17.20 | 97 | 25165 | 23606 | 63440154 |
| Platelet count decreased | 135.33 | 17.20 | 197 | 25065 | 115925 | 63347835 |
| Off label use | 129.57 | 17.20 | 570 | 24692 | 673892 | 62789868 |
| Drug reaction with eosinophilia and systemic symptoms | 114.13 | 17.20 | 100 | 25162 | 33736 | 63430024 |
| Mitochondrial toxicity | 106.84 | 17.20 | 27 | 25235 | 454 | 63463306 |
| Acute kidney injury | 103.54 | 17.20 | 283 | 24979 | 263132 | 63200628 |
| Hypertransaminasaemia | 99.93 | 17.20 | 50 | 25212 | 6559 | 63457201 |
| Respiratory failure | 99.14 | 17.20 | 159 | 25103 | 101699 | 63362061 |
| Bone marrow failure | 91.70 | 17.20 | 83 | 25179 | 29207 | 63434553 |
| Skin candida | 89.08 | 17.20 | 31 | 25231 | 1624 | 63462136 |
| Optic neuritis | 88.46 | 17.20 | 50 | 25212 | 8385 | 63455375 |
| Nasopharyngitis | 87.80 | 17.20 | 3 | 25259 | 254254 | 63209506 |
| Sepsis | 86.21 | 17.20 | 189 | 25073 | 152934 | 63310826 |
| Metabolic acidosis | 84.80 | 17.20 | 97 | 25165 | 44972 | 63418788 |
| Alopecia | 78.41 | 17.20 | 19 | 25243 | 337517 | 63126243 |
| Acute generalised exanthematous pustulosis | 78.23 | 17.20 | 51 | 25211 | 11048 | 63452712 |
| Hyperlactacidaemia | 76.04 | 17.20 | 32 | 25230 | 2817 | 63460943 |
| Hepatotoxicity | 75.29 | 17.20 | 83 | 25179 | 36958 | 63426802 |
| Bicytopenia | 73.15 | 17.20 | 30 | 25232 | 2475 | 63461285 |
| Joint swelling | 73.13 | 17.20 | 20 | 25242 | 327646 | 63136114 |
| Arthralgia | 72.59 | 17.20 | 72 | 25190 | 569638 | 62894122 |
| Renal failure | 70.53 | 17.20 | 149 | 25113 | 117503 | 63346257 |
| Staphylococcal infection | 69.64 | 17.20 | 84 | 25178 | 41172 | 63422588 |
| Eosinophilia | 68.32 | 17.20 | 63 | 25199 | 22693 | 63441067 |
| Clostridium difficile colitis | 67.77 | 17.20 | 60 | 25202 | 20509 | 63443251 |
| Infusion related reaction | 67.39 | 17.20 | 9 | 25253 | 245512 | 63218248 |
| Swelling | 64.92 | 17.20 | 15 | 25247 | 275363 | 63188397 |
| Ototoxicity | 63.76 | 17.20 | 23 | 25239 | 1339 | 63462421 |
| Rheumatoid arthritis | 63.59 | 17.20 | 12 | 25250 | 253807 | 63209953 |
| Polyneuropathy | 63.51 | 17.20 | 50 | 25212 | 14539 | 63449221 |
| Sinusitis | 62.94 | 17.20 | 8 | 25254 | 226645 | 63237115 |
| Candida infection | 61.93 | 17.20 | 66 | 25196 | 28285 | 63435475 |
| Aspergillus infection | 61.52 | 17.20 | 39 | 25223 | 8054 | 63455706 |
| Synovitis | 58.78 | 17.20 | 4 | 25258 | 186914 | 63276846 |
| Weight increased | 58.01 | 17.20 | 16 | 25246 | 260776 | 63202984 |
| Pancreatitis haemorrhagic | 53.39 | 17.20 | 16 | 25246 | 517 | 63463243 |
| Geotrichum infection | 50.84 | 17.20 | 15 | 25247 | 459 | 63463301 |
| Enterococcal infection | 50.32 | 17.20 | 34 | 25228 | 7814 | 63455946 |
| Product use in unapproved indication | 50.15 | 17.20 | 171 | 25091 | 178909 | 63284851 |
| Disseminated intravascular coagulation | 50.06 | 17.20 | 49 | 25213 | 19002 | 63444758 |
| Leukopenia | 49.95 | 17.20 | 101 | 25161 | 77189 | 63386571 |
| Hepatocellular injury | 49.92 | 17.20 | 58 | 25204 | 27323 | 63436437 |
| Pain in extremity | 49.33 | 17.20 | 36 | 25226 | 331450 | 63132310 |
| Product dose omission issue | 49.15 | 17.20 | 16 | 25246 | 234297 | 63229463 |
| Toxic optic neuropathy | 48.58 | 17.20 | 12 | 25250 | 183 | 63463577 |
| Posterior reversible encephalopathy syndrome | 48.19 | 17.20 | 46 | 25216 | 17299 | 63446461 |
| Aplasia pure red cell | 48.14 | 17.20 | 27 | 25235 | 4460 | 63459300 |
| Peripheral swelling | 47.85 | 17.20 | 23 | 25239 | 265919 | 63197841 |
| Multiple-drug resistance | 47.18 | 17.20 | 28 | 25234 | 5142 | 63458618 |
| Pancreatitis acute | 46.97 | 17.20 | 56 | 25206 | 27110 | 63436650 |
| Headache | 46.35 | 17.20 | 116 | 25146 | 633125 | 62830635 |
| Tongue discolouration | 45.23 | 17.20 | 23 | 25239 | 3120 | 63460640 |
| Hypomagnesaemia | 44.44 | 17.20 | 56 | 25206 | 28681 | 63435079 |
| Drug ineffective for unapproved indication | 44.36 | 17.20 | 61 | 25201 | 34002 | 63429758 |
| Discomfort | 43.90 | 17.20 | 7 | 25255 | 167367 | 63296393 |
| Cholestasis | 43.38 | 17.20 | 56 | 25206 | 29378 | 63434382 |
| Nervous system disorder | 43.32 | 17.20 | 45 | 25217 | 18721 | 63445039 |
| Hepatic cytolysis | 43.07 | 17.20 | 41 | 25221 | 15366 | 63448394 |
| Systemic lupus erythematosus | 42.54 | 17.20 | 15 | 25247 | 208903 | 63254857 |
| Vomiting | 41.00 | 17.20 | 370 | 24892 | 559247 | 62904513 |
| Klebsiella infection | 40.86 | 17.20 | 31 | 25231 | 8535 | 63455225 |
| Contraindicated product administered | 40.42 | 17.20 | 18 | 25244 | 217630 | 63246130 |
| Glossodynia | 39.71 | 17.20 | 11 | 25251 | 178865 | 63284895 |
| Pneumothorax | 39.36 | 17.20 | 40 | 25222 | 16221 | 63447539 |
| Paradoxical drug reaction | 39.23 | 17.20 | 23 | 25239 | 4129 | 63459631 |
| Toxic epidermal necrolysis | 38.59 | 17.20 | 49 | 25213 | 25285 | 63438475 |
| Rash maculo-papular | 38.38 | 17.20 | 55 | 25207 | 31841 | 63431919 |
| Oedematous kidney | 38.20 | 17.20 | 9 | 25253 | 111 | 63463649 |
| Fall | 37.97 | 17.20 | 61 | 25201 | 392273 | 63071487 |
| Infective pulmonary exacerbation of cystic fibrosis | 37.91 | 17.20 | 30 | 25232 | 8787 | 63454973 |
| Dysbiosis | 37.60 | 17.20 | 14 | 25248 | 892 | 63462868 |
| Blood creatine phosphokinase increased | 37.39 | 17.20 | 53 | 25209 | 30377 | 63433383 |
| Diabetic macroangiopathy | 37.28 | 17.20 | 9 | 25253 | 124 | 63463636 |
| Blood lactic acid increased | 36.83 | 17.20 | 27 | 25235 | 7059 | 63456701 |
| Tooth discolouration | 36.69 | 17.20 | 14 | 25248 | 954 | 63462806 |
| Drug level decreased | 36.33 | 17.20 | 28 | 25234 | 7891 | 63455869 |
| Wound | 36.31 | 17.20 | 10 | 25252 | 163253 | 63300507 |
| Pericarditis | 35.66 | 17.20 | 5 | 25257 | 131574 | 63332186 |
| Hepatic failure | 35.11 | 17.20 | 56 | 25206 | 35600 | 63428160 |
| Abdominal discomfort | 34.85 | 17.20 | 46 | 25216 | 320839 | 63142921 |
| Respiratory distress | 34.37 | 17.20 | 54 | 25208 | 33897 | 63429863 |
| Mobility decreased | 34.29 | 17.20 | 4 | 25258 | 121155 | 63342605 |
| Hepatic infarction | 33.78 | 17.20 | 12 | 25250 | 668 | 63463092 |
| Malaise | 33.75 | 17.20 | 72 | 25190 | 415882 | 63047878 |
| Bacteraemia | 33.74 | 17.20 | 38 | 25224 | 17310 | 63446450 |
| Contusion | 33.72 | 17.20 | 9 | 25253 | 150035 | 63313725 |
| Hypokalaemia | 33.42 | 17.20 | 104 | 25158 | 103700 | 63360060 |
| Blood disorder | 33.40 | 17.20 | 25 | 25237 | 6746 | 63457014 |
| Systemic candida | 33.39 | 17.20 | 19 | 25243 | 3226 | 63460534 |
| Musculoskeletal stiffness | 33.14 | 17.20 | 16 | 25246 | 184602 | 63279158 |
| Rash morbilliform | 32.96 | 17.20 | 19 | 25243 | 3306 | 63460454 |
| Toxic leukoencephalopathy | 32.62 | 17.20 | 12 | 25250 | 739 | 63463021 |
| Immune reconstitution inflammatory syndrome associated tuberculosis | 32.33 | 17.20 | 10 | 25252 | 360 | 63463400 |
| Haematotoxicity | 32.18 | 17.20 | 28 | 25234 | 9348 | 63454412 |
| Bronchopulmonary aspergillosis | 32.11 | 17.20 | 27 | 25235 | 8608 | 63455152 |
| Enterovesical fistula | 32.06 | 17.20 | 11 | 25251 | 552 | 63463208 |
| Brain abscess | 31.95 | 17.20 | 16 | 25246 | 2102 | 63461658 |
| Distributive shock | 31.86 | 17.20 | 14 | 25248 | 1369 | 63462391 |
| Encephalopathy | 31.82 | 17.20 | 56 | 25206 | 38564 | 63425196 |
| Oedematous pancreatitis | 31.72 | 17.20 | 11 | 25251 | 570 | 63463190 |
| Kussmaul respiration | 31.51 | 17.20 | 9 | 25253 | 245 | 63463515 |
| Hyponatraemia | 31.42 | 17.20 | 107 | 25155 | 111793 | 63351967 |
| Hyperbilirubinaemia | 31.42 | 17.20 | 30 | 25232 | 11284 | 63452476 |
| Aplasia | 31.07 | 17.20 | 20 | 25242 | 4239 | 63459521 |
| Acute respiratory distress syndrome | 30.42 | 17.20 | 42 | 25220 | 23492 | 63440268 |
| Acute hepatic failure | 30.40 | 17.20 | 37 | 25225 | 18290 | 63445470 |
| Transaminases abnormal | 30.25 | 17.20 | 11 | 25251 | 655 | 63463105 |
| Impaired healing | 30.00 | 17.20 | 3 | 25259 | 102539 | 63361221 |
| Toxic skin eruption | 29.92 | 17.20 | 31 | 25231 | 12854 | 63450906 |
| Back pain | 29.57 | 17.20 | 37 | 25225 | 264108 | 63199652 |
| Staphylococcal sepsis | 29.37 | 17.20 | 25 | 25237 | 8103 | 63455657 |
| Cholecystitis acute | 29.02 | 17.20 | 25 | 25237 | 8235 | 63455525 |
| Immune effector cell-associated neurotoxicity syndrome | 28.01 | 17.20 | 15 | 25247 | 2262 | 63461498 |
| Maternal exposure during pregnancy | 27.71 | 17.20 | 28 | 25234 | 220034 | 63243726 |
| Exfoliative rash | 27.50 | 17.20 | 16 | 25246 | 2831 | 63460929 |
| Mediastinal effusion | 26.99 | 17.20 | 6 | 25256 | 56 | 63463704 |
| Hypersensitivity | 26.91 | 17.20 | 47 | 25215 | 292638 | 63171122 |
| Neutropenia | 26.81 | 17.20 | 139 | 25123 | 174866 | 63288894 |
| Hallucination | 26.74 | 17.20 | 64 | 25198 | 54753 | 63409007 |
| Acid base balance abnormal | 26.62 | 17.20 | 8 | 25254 | 261 | 63463499 |
| Mycobacterium abscessus infection | 26.60 | 17.20 | 10 | 25252 | 654 | 63463106 |
| Transaminases increased | 26.51 | 17.20 | 46 | 25216 | 31321 | 63432439 |
| Electrolyte imbalance | 26.20 | 17.20 | 36 | 25226 | 20040 | 63443720 |
| Stevens-Johnson syndrome | 25.69 | 17.20 | 40 | 25222 | 24910 | 63438850 |
| Dermatitis exfoliative generalised | 25.62 | 17.20 | 17 | 25245 | 3790 | 63459970 |
| Migraine | 25.61 | 17.20 | 5 | 25257 | 103341 | 63360419 |
| Hyperoxaluria | 25.03 | 17.20 | 7 | 25255 | 176 | 63463584 |
| Enterococcal bacteraemia | 24.93 | 17.20 | 12 | 25250 | 1447 | 63462313 |
| Escherichia infection | 24.91 | 17.20 | 28 | 25234 | 12726 | 63451034 |
| Disseminated tuberculosis | 24.79 | 17.20 | 15 | 25247 | 2852 | 63460908 |
| Shock | 24.69 | 17.20 | 38 | 25224 | 23425 | 63440335 |
| Herbal toxicity | 24.29 | 17.20 | 5 | 25257 | 31 | 63463729 |
| Drug-induced liver injury | 24.14 | 17.20 | 51 | 25211 | 40171 | 63423589 |
| Meningitis tuberculous | 24.01 | 17.20 | 9 | 25253 | 584 | 63463176 |
| Therapeutic product effect incomplete | 23.74 | 17.20 | 10 | 25252 | 125046 | 63338714 |
| Bronchitis | 23.71 | 17.20 | 10 | 25252 | 124925 | 63338835 |
| Neutrophil count decreased | 23.47 | 17.20 | 62 | 25200 | 56344 | 63407416 |
| Metabolic encephalopathy | 23.34 | 17.20 | 19 | 25243 | 5790 | 63457970 |
| Sideroblastic anaemia | 23.28 | 17.20 | 4 | 25258 | 7 | 63463753 |
| Wound infection staphylococcal | 23.16 | 17.20 | 14 | 25248 | 2658 | 63461102 |
| Eosinophilic pneumonia acute | 23.01 | 17.20 | 8 | 25254 | 418 | 63463342 |
| Pyelonephritis chronic | 22.99 | 17.20 | 7 | 25255 | 239 | 63463521 |
| Gastrooesophageal reflux disease | 22.93 | 17.20 | 5 | 25257 | 95634 | 63368126 |
| Portal vein cavernous transformation | 22.86 | 17.20 | 6 | 25256 | 118 | 63463642 |
| Butterfly rash | 22.71 | 17.20 | 12 | 25250 | 1761 | 63461999 |
| Cough | 22.63 | 17.20 | 52 | 25210 | 292691 | 63171069 |
| Myopathy | 22.60 | 17.20 | 25 | 25237 | 11166 | 63452594 |
| Inappropriate antidiuretic hormone secretion | 22.13 | 17.20 | 29 | 25233 | 15433 | 63448327 |
| Psoriasis | 21.99 | 17.20 | 4 | 25258 | 86953 | 63376807 |
| Haemophagocytic lymphohistiocytosis | 21.91 | 17.20 | 24 | 25238 | 10603 | 63453157 |
| Leuconostoc infection | 21.78 | 17.20 | 4 | 25258 | 12 | 63463748 |
| Pancreatitis | 21.52 | 17.20 | 55 | 25207 | 49000 | 63414760 |
| Neurotoxicity | 21.48 | 17.20 | 30 | 25232 | 16960 | 63446800 |
| Vascular device infection | 21.47 | 17.20 | 20 | 25242 | 7292 | 63456468 |
| Procalcitonin increased | 21.23 | 17.20 | 10 | 25252 | 1149 | 63462611 |
| Abdominal rigidity | 21.23 | 17.20 | 12 | 25250 | 2012 | 63461748 |
| Dysmetria | 21.20 | 17.20 | 8 | 25254 | 529 | 63463231 |
| Infectious pleural effusion | 21.09 | 17.20 | 11 | 25251 | 1572 | 63462188 |
| Septal panniculitis | 21.05 | 17.20 | 5 | 25257 | 64 | 63463696 |
| Hypoglycaemia | 21.03 | 17.20 | 62 | 25200 | 60003 | 63403757 |
| Renal impairment | 20.97 | 17.20 | 80 | 25182 | 88275 | 63375485 |
| Pseudomonas infection | 20.85 | 17.20 | 24 | 25238 | 11189 | 63452571 |
| Blood fibrinogen decreased | 20.84 | 17.20 | 9 | 25253 | 844 | 63462916 |
| Tuberculoma of central nervous system | 20.62 | 17.20 | 7 | 25255 | 340 | 63463420 |
| Haemoglobin decreased | 20.53 | 17.20 | 113 | 25149 | 145372 | 63318388 |
| Peripheral motor neuropathy | 20.47 | 17.20 | 11 | 25251 | 1670 | 63462090 |
| Memory impairment | 20.34 | 17.20 | 8 | 25254 | 104250 | 63359510 |
| Agranulocytosis | 20.13 | 17.20 | 36 | 25226 | 25098 | 63438662 |
| Epstein-Barr virus test positive | 20.02 | 17.20 | 8 | 25254 | 617 | 63463143 |
| Mouth ulceration | 20.00 | 17.20 | 42 | 25220 | 32942 | 63430818 |
| Muscle spasms | 19.50 | 17.20 | 20 | 25242 | 156130 | 63307630 |
| Pruritus | 19.44 | 17.20 | 76 | 25186 | 361377 | 63102383 |
| Hyperpyrexia | 19.24 | 17.20 | 14 | 25248 | 3618 | 63460142 |
| Hypotension | 19.23 | 17.20 | 179 | 25083 | 272425 | 63191335 |
| Wheezing | 19.21 | 17.20 | 7 | 25255 | 95588 | 63368172 |
| Pyrexia | 18.90 | 17.20 | 277 | 24985 | 470201 | 62993559 |
| Pneumonia necrotising | 18.74 | 17.20 | 7 | 25255 | 450 | 63463310 |
| Delayed graft function | 18.71 | 17.20 | 9 | 25253 | 1084 | 63462676 |
| Hepatitis cholestatic | 18.65 | 17.20 | 18 | 25244 | 6860 | 63456900 |
| Feeling abnormal | 18.53 | 17.20 | 19 | 25243 | 148373 | 63315387 |
| Insomnia | 18.50 | 17.20 | 36 | 25226 | 215216 | 63248544 |
| Hyperalbuminaemia | 18.43 | 17.20 | 4 | 25258 | 33 | 63463727 |
| Hallucination, olfactory | 18.35 | 17.20 | 6 | 25256 | 259 | 63463501 |
| Hepatitis toxic | 18.29 | 17.20 | 13 | 25249 | 3240 | 63460520 |
| Acinetobacter infection | 18.28 | 17.20 | 10 | 25252 | 1573 | 63462187 |
| Ill-defined disorder | 18.18 | 17.20 | 5 | 25257 | 81750 | 63382010 |
| Dizziness | 18.02 | 17.20 | 99 | 25163 | 429826 | 63033934 |
| Mixed liver injury | 18.01 | 17.20 | 15 | 25247 | 4720 | 63459040 |
| Mental status changes | 18.00 | 17.20 | 45 | 25217 | 39554 | 63424206 |
| Aspartate aminotransferase increased | 17.67 | 17.20 | 77 | 25185 | 90200 | 63373560 |
| Generalised tonic-clonic seizure | 17.65 | 17.20 | 37 | 25225 | 28979 | 63434781 |
| Trichoglossia | 17.64 | 17.20 | 6 | 25256 | 293 | 63463467 |
| Lower respiratory tract infection | 17.62 | 17.20 | 16 | 25246 | 132291 | 63331469 |
| Tuberculosis | 17.57 | 17.20 | 22 | 25240 | 11189 | 63452571 |
| Tuberculin test positive | 17.40 | 17.20 | 13 | 25249 | 3498 | 63460262 |
| Deafness | 17.40 | 17.20 | 28 | 25234 | 17929 | 63445831 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Thrombocytopenia | 928.14 | 15.62 | 905 | 30632 | 155342 | 34770052 |
| Serotonin syndrome | 583.40 | 15.62 | 307 | 31230 | 19626 | 34905768 |
| Lactic acidosis | 389.64 | 15.62 | 291 | 31246 | 34481 | 34890913 |
| Electrocardiogram QT prolonged | 345.49 | 15.62 | 290 | 31247 | 40662 | 34884732 |
| Optic neuropathy | 321.41 | 15.62 | 104 | 31433 | 1861 | 34923533 |
| Drug resistance | 281.47 | 15.62 | 213 | 31324 | 25714 | 34899680 |
| Anaemia | 276.16 | 15.62 | 632 | 30905 | 232703 | 34692691 |
| Pancytopenia | 266.55 | 15.62 | 376 | 31161 | 94781 | 34830613 |
| Off label use | 208.36 | 15.62 | 836 | 30701 | 418688 | 34506706 |
| Choroiditis | 193.39 | 15.62 | 63 | 31474 | 1152 | 34924242 |
| Platelet count decreased | 170.45 | 15.62 | 350 | 31187 | 119367 | 34806027 |
| Pathogen resistance | 169.51 | 15.62 | 106 | 31431 | 9376 | 34916018 |
| Fatigue | 169.10 | 15.62 | 62 | 31475 | 370591 | 34554803 |
| Neuropathy peripheral | 168.18 | 15.62 | 283 | 31254 | 82980 | 34842414 |
| Drug reaction with eosinophilia and systemic symptoms | 157.96 | 15.62 | 171 | 31366 | 32841 | 34892553 |
| Enterococcal infection | 151.34 | 15.62 | 98 | 31439 | 9208 | 34916186 |
| Drug interaction | 149.37 | 15.62 | 495 | 31042 | 225451 | 34699943 |
| Bone marrow failure | 140.77 | 15.62 | 152 | 31385 | 29101 | 34896293 |
| Antimicrobial susceptibility test resistant | 123.19 | 15.62 | 34 | 31503 | 340 | 34925054 |
| Optic neuritis | 118.69 | 15.62 | 60 | 31477 | 3514 | 34921880 |
| Hepatotoxicity | 114.68 | 15.62 | 118 | 31419 | 21367 | 34904027 |
| Septic shock | 114.08 | 15.62 | 220 | 31317 | 71614 | 34853780 |
| Rash maculo-papular | 106.74 | 15.62 | 130 | 31407 | 28321 | 34897073 |
| Trichoglossia | 104.27 | 15.62 | 29 | 31508 | 299 | 34925095 |
| Eosinophilia | 101.94 | 15.62 | 122 | 31415 | 26100 | 34899294 |
| Bicytopenia | 97.07 | 15.62 | 46 | 31491 | 2338 | 34923056 |
| Multiple organ dysfunction syndrome | 95.14 | 15.62 | 212 | 31325 | 76354 | 34849040 |
| Product use in unapproved indication | 87.00 | 15.62 | 268 | 31269 | 117231 | 34808163 |
| Visual acuity reduced | 86.72 | 15.62 | 89 | 31448 | 16060 | 34909334 |
| Bronchopulmonary aspergillosis | 86.45 | 15.62 | 85 | 31452 | 14574 | 34910820 |
| Pain | 85.35 | 15.62 | 39 | 31498 | 204636 | 34720758 |
| Myelosuppression | 82.14 | 15.62 | 94 | 31443 | 19171 | 34906223 |
| Candida infection | 81.62 | 15.62 | 90 | 31447 | 17625 | 34907769 |
| Drug ineffective for unapproved indication | 78.80 | 15.62 | 102 | 31435 | 23613 | 34901781 |
| Intraocular pressure increased | 78.56 | 15.62 | 53 | 31484 | 5330 | 34920064 |
| Fall | 76.62 | 15.62 | 44 | 31493 | 202841 | 34722553 |
| Polyneuropathy | 76.22 | 15.62 | 80 | 31457 | 14816 | 34910578 |
| Systemic candida | 75.13 | 15.62 | 45 | 31492 | 3681 | 34921713 |
| Alveolar lung disease | 73.74 | 15.62 | 23 | 31514 | 363 | 34925031 |
| Uveitis | 71.05 | 15.62 | 57 | 31480 | 7478 | 34917916 |
| Hyperlactacidaemia | 67.58 | 15.62 | 39 | 31498 | 2977 | 34922417 |
| Hypersensitivity vasculitis | 63.95 | 15.62 | 39 | 31498 | 3296 | 34922098 |
| Ototoxicity | 63.12 | 15.62 | 32 | 31505 | 1885 | 34923509 |
| Eye pain | 63.06 | 15.62 | 69 | 31468 | 13393 | 34912001 |
| Toxic optic neuropathy | 62.89 | 15.62 | 25 | 31512 | 825 | 34924569 |
| Back pain | 61.29 | 15.62 | 17 | 31520 | 121772 | 34803622 |
| Respiratory failure | 61.17 | 15.62 | 226 | 31311 | 108346 | 34817048 |
| Sideroblastic anaemia | 60.44 | 15.62 | 18 | 31519 | 241 | 34925153 |
| Product dose omission issue | 59.70 | 15.62 | 17 | 31520 | 119694 | 34805700 |
| Minimum inhibitory concentration | 57.44 | 15.62 | 16 | 31521 | 166 | 34925228 |
| Mitochondrial toxicity | 55.47 | 15.62 | 33 | 31504 | 2666 | 34922728 |
| Tooth discolouration | 55.42 | 15.62 | 19 | 31518 | 409 | 34924985 |
| Hypertransaminasaemia | 54.11 | 15.62 | 43 | 31494 | 5563 | 34919831 |
| Cardiac valve vegetation | 52.86 | 15.62 | 19 | 31518 | 472 | 34924922 |
| Drug ineffective | 52.47 | 15.62 | 635 | 30902 | 456116 | 34469278 |
| Eosinophilic pneumonia | 52.36 | 15.62 | 35 | 31502 | 3466 | 34921928 |
| Cholestasis | 50.87 | 15.62 | 89 | 31448 | 26859 | 34898535 |
| Arthralgia | 49.81 | 15.62 | 48 | 31489 | 169993 | 34755401 |
| Klebsiella infection | 49.43 | 15.62 | 49 | 31488 | 8482 | 34916912 |
| Product use issue | 49.34 | 15.62 | 147 | 31390 | 63069 | 34862325 |
| Reticulocytopenia | 48.73 | 15.62 | 13 | 31524 | 113 | 34925281 |
| Geotrichum infection | 48.67 | 15.62 | 18 | 31519 | 486 | 34924908 |
| Tongue discolouration | 48.11 | 15.62 | 23 | 31514 | 1192 | 34924202 |
| Hypolipidaemia | 48.09 | 15.62 | 8 | 31529 | 0 | 34925394 |
| Dizziness | 47.05 | 15.62 | 78 | 31459 | 218443 | 34706951 |
| Disseminated intravascular coagulation | 46.41 | 15.62 | 76 | 31461 | 21740 | 34903654 |
| Deafness neurosensory | 46.09 | 15.62 | 30 | 31507 | 2841 | 34922553 |
| Treatment failure | 45.76 | 15.62 | 118 | 31419 | 46579 | 34878815 |
| Completed suicide | 45.27 | 15.62 | 16 | 31521 | 98152 | 34827242 |
| Enterococcus test positive | 44.67 | 15.62 | 21 | 31516 | 1048 | 34924346 |
| Incorrect product administration duration | 44.52 | 15.62 | 36 | 31501 | 4775 | 34920619 |
| Pulmonary interstitial emphysema syndrome | 44.38 | 15.62 | 17 | 31520 | 507 | 34924887 |
| Renal impairment | 43.72 | 15.62 | 185 | 31352 | 94328 | 34831066 |
| Death | 43.64 | 15.62 | 198 | 31339 | 397851 | 34527543 |
| Staphylococcal infection | 43.23 | 15.62 | 93 | 31444 | 32667 | 34892727 |
| Acute kidney injury | 42.62 | 15.62 | 441 | 31096 | 304547 | 34620847 |
| Differentiation syndrome | 41.58 | 15.62 | 22 | 31515 | 1416 | 34923978 |
| Sepsis | 41.11 | 15.62 | 274 | 31263 | 166287 | 34759107 |
| Drug dispensed to wrong patient | 40.83 | 15.62 | 16 | 31521 | 508 | 34924886 |
| Tubulointerstitial nephritis | 39.11 | 15.62 | 69 | 31468 | 20955 | 34904439 |
| Nasopharyngitis | 38.65 | 15.62 | 8 | 31529 | 69960 | 34855434 |
| Deafness | 38.27 | 15.62 | 49 | 31488 | 11216 | 34914178 |
| Therapeutic response delayed | 37.78 | 15.62 | 16 | 31521 | 622 | 34924772 |
| Drug-induced liver injury | 37.07 | 15.62 | 81 | 31456 | 28751 | 34896643 |
| Myocardial infarction | 36.83 | 15.62 | 33 | 31504 | 121052 | 34804342 |
| Malignant neoplasm progression | 36.29 | 15.62 | 17 | 31520 | 88029 | 34837365 |
| Headache | 35.85 | 15.62 | 80 | 31457 | 200555 | 34724839 |
| Acute generalised exanthematous pustulosis | 35.75 | 15.62 | 37 | 31500 | 6739 | 34918655 |
| Aortoenteric fistula | 34.65 | 15.62 | 10 | 31527 | 119 | 34925275 |
| Hepatic failure | 34.59 | 15.62 | 88 | 31449 | 34443 | 34890951 |
| Constipation | 34.24 | 15.62 | 44 | 31493 | 136938 | 34788456 |
| Leukopenia | 33.82 | 15.62 | 129 | 31408 | 62727 | 34862667 |
| Muscle spasms | 31.65 | 15.62 | 14 | 31523 | 74987 | 34850407 |
| Pulmonary mucormycosis | 31.54 | 15.62 | 15 | 31522 | 768 | 34924626 |
| Hepatitis cholestatic | 30.90 | 15.62 | 37 | 31500 | 7910 | 34917484 |
| Mucormycosis | 30.55 | 15.62 | 32 | 31505 | 5910 | 34919484 |
| CNS ventriculitis | 30.46 | 15.62 | 11 | 31526 | 277 | 34925117 |
| Dehydration | 30.21 | 15.62 | 44 | 31493 | 129925 | 34795469 |
| Myoclonus | 29.58 | 15.62 | 50 | 31487 | 14675 | 34910719 |
| Chest pain | 29.38 | 15.62 | 43 | 31494 | 126719 | 34798675 |
| Cytopenia | 29.35 | 15.62 | 46 | 31491 | 12677 | 34912717 |
| Aspergillus infection | 29.24 | 15.62 | 45 | 31492 | 12209 | 34913185 |
| Nutritional condition abnormal | 29.17 | 15.62 | 12 | 31525 | 433 | 34924961 |
| Inappropriate schedule of product administration | 28.97 | 15.62 | 10 | 31527 | 62286 | 34863108 |
| Weight increased | 28.71 | 15.62 | 25 | 31512 | 93008 | 34832386 |
| Intentional overdose | 28.70 | 15.62 | 3 | 31534 | 43671 | 34881723 |
| Respiratory gas exchange disorder | 28.49 | 15.62 | 12 | 31525 | 460 | 34924934 |
| Peripheral swelling | 28.27 | 15.62 | 17 | 31520 | 76524 | 34848870 |
| Cardiac disorder | 28.24 | 15.62 | 3 | 31534 | 43123 | 34882271 |
| Toxic epidermal necrolysis | 28.04 | 15.62 | 61 | 31476 | 21585 | 34903809 |
| Aplasia pure red cell | 27.97 | 15.62 | 31 | 31506 | 6101 | 34919293 |
| Botulism | 27.75 | 15.62 | 9 | 31528 | 162 | 34925232 |
| Vascular pseudoaneurysm thrombosis | 27.70 | 15.62 | 7 | 31530 | 48 | 34925346 |
| Mixed liver injury | 27.65 | 15.62 | 22 | 31515 | 2851 | 34922543 |
| Intentional product use issue | 27.57 | 15.62 | 117 | 31420 | 59699 | 34865695 |
| Cholangiolitis | 27.53 | 15.62 | 6 | 31531 | 19 | 34925375 |
| Staphylococcal bacteraemia | 27.51 | 15.62 | 36 | 31501 | 8416 | 34916978 |
| Optic nerve disorder | 27.46 | 15.62 | 13 | 31524 | 659 | 34924735 |
| Joint swelling | 27.19 | 15.62 | 10 | 31527 | 59880 | 34865514 |
| Haematotoxicity | 26.83 | 15.62 | 35 | 31502 | 8159 | 34917235 |
| Gastrointestinal disorder | 26.52 | 15.62 | 79 | 31458 | 33869 | 34891525 |
| Musculoskeletal stiffness | 26.48 | 15.62 | 5 | 31532 | 46675 | 34878719 |
| Memory impairment | 25.98 | 15.62 | 4 | 31533 | 43314 | 34882080 |
| Coronary artery disease | 25.71 | 15.62 | 6 | 31531 | 48299 | 34877095 |
| Shock | 25.66 | 15.62 | 63 | 31474 | 24116 | 34901278 |
| Haemodynamic instability | 25.63 | 15.62 | 37 | 31500 | 9486 | 34915908 |
| Acinetobacter infection | 25.44 | 15.62 | 15 | 31522 | 1192 | 34924202 |
| Cough | 25.09 | 15.62 | 62 | 31475 | 150078 | 34775316 |
| Diffuse alveolar damage | 25.05 | 15.62 | 19 | 31518 | 2295 | 34923099 |
| Malaise | 25.02 | 15.62 | 85 | 31452 | 185740 | 34739654 |
| Rectal perforation | 25.02 | 15.62 | 11 | 31526 | 469 | 34924925 |
| Condition aggravated | 24.93 | 15.62 | 274 | 31263 | 191922 | 34733472 |
| Normocytic anaemia | 24.83 | 15.62 | 19 | 31518 | 2325 | 34923069 |
| Injection site pain | 24.82 | 15.62 | 3 | 31534 | 39002 | 34886392 |
| Haemophagocytic lymphohistiocytosis | 24.68 | 15.62 | 43 | 31494 | 12930 | 34912464 |
| Psoriasis | 24.66 | 15.62 | 3 | 31534 | 38809 | 34886585 |
| Pain in extremity | 24.63 | 15.62 | 48 | 31489 | 126465 | 34798929 |
| Transaminases increased | 24.45 | 15.62 | 66 | 31471 | 26757 | 34898637 |
| Axonal neuropathy | 24.32 | 15.62 | 14 | 31523 | 1063 | 34924331 |
| Insomnia | 24.32 | 15.62 | 35 | 31502 | 103872 | 34821522 |
| Foetal exposure during pregnancy | 24.07 | 15.62 | 3 | 31534 | 38098 | 34887296 |
| Cardiac failure congestive | 23.78 | 15.62 | 24 | 31513 | 83246 | 34842148 |
| Intervertebral discitis | 23.71 | 15.62 | 18 | 31519 | 2177 | 34923217 |
| Hypoacusis | 23.50 | 15.62 | 48 | 31489 | 16253 | 34909141 |
| Pseudomonas infection | 23.50 | 15.62 | 41 | 31496 | 12341 | 34913053 |
| Nocardiosis | 23.45 | 15.62 | 23 | 31514 | 3928 | 34921466 |
| Generalised oedema | 23.43 | 15.62 | 41 | 31496 | 12367 | 34913027 |
| Pruritus | 23.43 | 15.62 | 59 | 31478 | 141922 | 34783472 |
| Hypofibrinogenaemia | 23.18 | 15.62 | 16 | 31521 | 1670 | 34923724 |
| Dyspnoea | 23.14 | 15.62 | 223 | 31314 | 376559 | 34548835 |
| Hyperleukocytosis | 22.92 | 15.62 | 17 | 31520 | 1985 | 34923409 |
| Asthenia | 22.80 | 15.62 | 129 | 31408 | 245122 | 34680272 |
| Clostridium test positive | 22.78 | 15.62 | 21 | 31516 | 3321 | 34922073 |
| Bronchitis | 22.75 | 15.62 | 5 | 31532 | 41958 | 34883436 |
| Tuberculosis | 22.61 | 15.62 | 33 | 31504 | 8544 | 34916850 |
| Wrong technique in product usage process | 22.33 | 15.62 | 3 | 31534 | 35983 | 34889411 |
| Peripheral sensory neuropathy | 22.33 | 15.62 | 29 | 31508 | 6731 | 34918663 |
| Gait disturbance | 21.62 | 15.62 | 27 | 31510 | 85113 | 34840281 |
| Endocarditis | 21.61 | 15.62 | 28 | 31509 | 6483 | 34918911 |
| Hepatitis acute | 21.14 | 15.62 | 30 | 31507 | 7571 | 34917823 |
| Dysbiosis | 20.99 | 15.62 | 10 | 31527 | 514 | 34924880 |
| Metastases to muscle | 20.93 | 15.62 | 8 | 31529 | 237 | 34925157 |
| Atrial fibrillation | 20.86 | 15.62 | 50 | 31487 | 122343 | 34803051 |
| Metastases to retroperitoneum | 20.59 | 15.62 | 8 | 31529 | 248 | 34925146 |
| Toxic neuropathy | 20.38 | 15.62 | 10 | 31527 | 549 | 34924845 |
| Syncope | 20.24 | 15.62 | 32 | 31505 | 91419 | 34833975 |
| Organ failure | 20.10 | 15.62 | 16 | 31521 | 2075 | 34923319 |
| Rheumatoid arthritis | 19.85 | 15.62 | 5 | 31532 | 38233 | 34887161 |
| Acute myocardial infarction | 19.73 | 15.62 | 12 | 31525 | 53707 | 34871687 |
| Mycobacterium chelonae infection | 19.50 | 15.62 | 11 | 31526 | 804 | 34924590 |
| Splenic infection fungal | 19.33 | 15.62 | 6 | 31531 | 93 | 34925301 |
| Myasthenia gravis crisis | 19.29 | 15.62 | 10 | 31527 | 617 | 34924777 |
| Chorioretinitis | 19.28 | 15.62 | 9 | 31528 | 442 | 34924952 |
| Wound dehiscence | 19.14 | 15.62 | 19 | 31518 | 3292 | 34922102 |
| Acute respiratory distress syndrome | 18.94 | 15.62 | 59 | 31478 | 25910 | 34899484 |
| Herpes zoster meningoencephalitis | 18.79 | 15.62 | 8 | 31529 | 315 | 34925079 |
| Depression | 18.75 | 15.62 | 37 | 31500 | 97061 | 34828333 |
| Somnolence | 18.46 | 15.62 | 46 | 31491 | 111070 | 34814324 |
| Feeling abnormal | 18.31 | 15.62 | 18 | 31519 | 63217 | 34862177 |
| Shock haemorrhagic | 18.26 | 15.62 | 35 | 31502 | 11319 | 34914075 |
| Brain abscess | 18.19 | 15.62 | 18 | 31519 | 3107 | 34922287 |
| Toxic skin eruption | 18.19 | 15.62 | 35 | 31502 | 11350 | 34914044 |
| Blood glucose increased | 18.18 | 15.62 | 20 | 31517 | 66698 | 34858696 |
| Balance disorder | 18.10 | 15.62 | 7 | 31530 | 40647 | 34884747 |
| Nosocomial infection | 18.03 | 15.62 | 12 | 31525 | 1179 | 34924215 |
| Splenic necrosis | 18.01 | 15.62 | 6 | 31531 | 118 | 34925276 |
| Spontaneous haematoma | 17.86 | 15.62 | 9 | 31528 | 523 | 34924871 |
| Encephalopathy | 17.77 | 15.62 | 71 | 31466 | 35248 | 34890146 |
| Renal failure | 17.77 | 15.62 | 188 | 31349 | 130369 | 34795025 |
| Metastases to bone marrow | 17.77 | 15.62 | 9 | 31528 | 529 | 34924865 |
| Stress | 17.75 | 15.62 | 3 | 31534 | 30344 | 34895050 |
| Infective pulmonary exacerbation of cystic fibrosis | 17.69 | 15.62 | 26 | 31511 | 6775 | 34918619 |
| Endocarditis bacterial | 17.67 | 15.62 | 11 | 31526 | 964 | 34924430 |
| Blood pressure increased | 17.51 | 15.62 | 33 | 31504 | 88069 | 34837325 |
| Agranulocytosis | 17.26 | 15.62 | 54 | 31483 | 23767 | 34901627 |
| Musculoskeletal pain | 16.94 | 15.62 | 4 | 31533 | 31959 | 34893435 |
| Nephropathy toxic | 16.90 | 15.62 | 36 | 31501 | 12552 | 34912842 |
| Hepatitis toxic | 16.82 | 15.62 | 15 | 31522 | 2272 | 34923122 |
| Wrong patient received product | 16.79 | 15.62 | 16 | 31521 | 2638 | 34922756 |
| Hepatic cytolysis | 16.70 | 15.62 | 39 | 31498 | 14457 | 34910937 |
| Hepatocellular injury | 16.70 | 15.62 | 51 | 31486 | 22160 | 34903234 |
| Cerebrovascular accident | 16.65 | 15.62 | 32 | 31505 | 84779 | 34840615 |
| Immune reconstitution inflammatory syndrome | 16.61 | 15.62 | 29 | 31508 | 8730 | 34916664 |
| Urinary retention | 16.57 | 15.62 | 6 | 31531 | 36282 | 34889112 |
| Extradural abscess | 16.44 | 15.62 | 10 | 31527 | 841 | 34924553 |
| Cognitive disorder | 16.43 | 15.62 | 3 | 31534 | 28690 | 34896704 |
| Dry skin | 16.42 | 15.62 | 4 | 31533 | 31283 | 34894111 |
| Retinopathy hypertensive | 16.34 | 15.62 | 7 | 31530 | 280 | 34925114 |
| Spinal cord disorder | 16.33 | 15.62 | 10 | 31527 | 851 | 34924543 |
| Purpura non-thrombocytopenic | 16.26 | 15.62 | 5 | 31532 | 75 | 34925319 |
| Hyperhidrosis | 16.26 | 15.62 | 27 | 31510 | 75665 | 34849729 |
| Confusional state | 16.20 | 15.62 | 200 | 31337 | 143960 | 34781434 |
| Chondritis | 16.15 | 15.62 | 6 | 31531 | 164 | 34925230 |
| Pericarditis tuberculous | 16.14 | 15.62 | 5 | 31532 | 77 | 34925317 |
| Gastrooesophageal reflux disease | 16.12 | 15.62 | 7 | 31530 | 37917 | 34887477 |
| Enterobacter infection | 16.04 | 15.62 | 15 | 31522 | 2415 | 34922979 |
| Hypocapnia | 15.99 | 15.62 | 6 | 31531 | 169 | 34925225 |
| Red blood cell vacuolisation | 15.96 | 15.62 | 3 | 31534 | 3 | 34925391 |
| Metastases to spleen | 15.94 | 15.62 | 8 | 31529 | 461 | 34924933 |
| Hyperbilirubinaemia | 15.91 | 15.62 | 42 | 31495 | 16801 | 34908593 |
| Nail bed inflammation | 15.89 | 15.62 | 6 | 31531 | 172 | 34925222 |
| Angular cheilitis | 15.85 | 15.62 | 6 | 31531 | 173 | 34925221 |
| Hypoperfusion | 15.73 | 15.62 | 11 | 31526 | 1172 | 34924222 |
| Bilirubin conjugated increased | 15.72 | 15.62 | 17 | 31520 | 3254 | 34922140 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Thrombocytopenia | 1579.73 | 14.96 | 1345 | 51548 | 263914 | 79427581 |
| Serotonin syndrome | 1020.84 | 14.96 | 528 | 52365 | 44499 | 79646996 |
| Lactic acidosis | 976.77 | 14.96 | 598 | 52295 | 69761 | 79621734 |
| Anaemia | 608.92 | 14.96 | 1070 | 51823 | 443945 | 79247550 |
| Electrocardiogram QT prolonged | 536.76 | 14.96 | 459 | 52434 | 89927 | 79601568 |
| Drug resistance | 520.38 | 14.96 | 333 | 52560 | 41880 | 79649615 |
| Optic neuropathy | 495.23 | 14.96 | 154 | 52739 | 3330 | 79688165 |
| Pancytopenia | 488.31 | 14.96 | 575 | 52318 | 165170 | 79526325 |
| Pathogen resistance | 397.77 | 14.96 | 193 | 52700 | 14149 | 79677346 |
| Neuropathy peripheral | 374.81 | 14.96 | 465 | 52428 | 140840 | 79550655 |
| Off label use | 347.97 | 14.96 | 1350 | 51543 | 905865 | 78785630 |
| Drug interaction | 330.09 | 14.96 | 799 | 52094 | 414384 | 79277111 |
| Multiple organ dysfunction syndrome | 311.26 | 14.96 | 391 | 52502 | 119855 | 79571640 |
| Fatigue | 294.47 | 14.96 | 125 | 52768 | 929602 | 78761893 |
| Platelet count decreased | 281.88 | 14.96 | 481 | 52412 | 194183 | 79497312 |
| Septic shock | 278.33 | 14.96 | 374 | 52519 | 122427 | 79569068 |
| Drug reaction with eosinophilia and systemic symptoms | 271.60 | 14.96 | 270 | 52623 | 63974 | 79627521 |
| Pain | 248.91 | 14.96 | 79 | 52814 | 703723 | 78987772 |
| Choroiditis | 212.99 | 14.96 | 65 | 52828 | 1316 | 79690179 |
| Bone marrow failure | 205.35 | 14.96 | 209 | 52684 | 50898 | 79640597 |
| Myelosuppression | 203.76 | 14.96 | 187 | 52706 | 40109 | 79651386 |
| Optic neuritis | 193.77 | 14.96 | 104 | 52789 | 9416 | 79682079 |
| Enterococcal infection | 191.52 | 14.96 | 123 | 52770 | 15537 | 79675958 |
| Hepatotoxicity | 177.81 | 14.96 | 194 | 52699 | 51158 | 79640337 |
| Eosinophilia | 175.94 | 14.96 | 182 | 52711 | 45163 | 79646332 |
| Bicytopenia | 167.16 | 14.96 | 75 | 52818 | 4595 | 79686900 |
| Polyneuropathy | 150.01 | 14.96 | 126 | 52767 | 24025 | 79667470 |
| Arthralgia | 146.70 | 14.96 | 100 | 52793 | 571703 | 79119792 |
| Mitochondrial toxicity | 144.24 | 14.96 | 60 | 52833 | 3054 | 79688441 |
| Hypertransaminasaemia | 144.19 | 14.96 | 93 | 52800 | 11831 | 79679664 |
| Hyperlactacidaemia | 142.30 | 14.96 | 71 | 52822 | 5524 | 79685971 |
| Antimicrobial susceptibility test resistant | 142.14 | 14.96 | 36 | 52857 | 352 | 79691143 |
| Product use in unapproved indication | 141.09 | 14.96 | 425 | 52468 | 249934 | 79441561 |
| Rash maculo-papular | 139.63 | 14.96 | 179 | 52714 | 55899 | 79635596 |
| Acute kidney injury | 130.72 | 14.96 | 684 | 52209 | 518720 | 79172775 |
| Respiratory failure | 130.40 | 14.96 | 336 | 52557 | 180575 | 79510920 |
| Nasopharyngitis | 130.40 | 14.96 | 10 | 52883 | 253871 | 79437624 |
| Candida infection | 123.02 | 14.96 | 139 | 52754 | 38075 | 79653420 |
| Fall | 121.42 | 14.96 | 88 | 52805 | 487541 | 79203954 |
| Drug ineffective for unapproved indication | 120.47 | 14.96 | 159 | 52734 | 51079 | 79640416 |
| Bronchopulmonary aspergillosis | 119.63 | 14.96 | 107 | 52786 | 22187 | 79669308 |
| Trichoglossia | 118.85 | 14.96 | 35 | 52858 | 624 | 79690871 |
| Completed suicide | 114.86 | 14.96 | 14 | 52879 | 245753 | 79445742 |
| Joint swelling | 111.82 | 14.96 | 27 | 52866 | 288619 | 79402876 |
| Ototoxicity | 105.89 | 14.96 | 49 | 52844 | 3225 | 79688270 |
| Arthropathy | 103.60 | 14.96 | 3 | 52890 | 177108 | 79514387 |
| Toxic optic neuropathy | 103.44 | 14.96 | 36 | 52857 | 1117 | 79690378 |
| Acute generalised exanthematous pustulosis | 100.97 | 14.96 | 87 | 52806 | 17167 | 79674328 |
| Systemic candida | 100.59 | 14.96 | 60 | 52833 | 6646 | 79684849 |
| Staphylococcal infection | 100.40 | 14.96 | 156 | 52737 | 58139 | 79633356 |
| Geotrichum infection | 97.23 | 14.96 | 33 | 52860 | 948 | 79690547 |
| Rheumatoid arthritis | 97.09 | 14.96 | 12 | 52881 | 208458 | 79483037 |
| Product dose omission issue | 96.17 | 14.96 | 23 | 52870 | 247514 | 79443981 |
| Headache | 95.98 | 14.96 | 180 | 52713 | 653592 | 79037903 |
| Sepsis | 95.06 | 14.96 | 392 | 52501 | 269036 | 79422459 |
| Weight increased | 91.11 | 14.96 | 35 | 52858 | 277351 | 79414144 |
| Disseminated intravascular coagulation | 87.00 | 14.96 | 113 | 52780 | 35729 | 79655766 |
| Visual acuity reduced | 86.13 | 14.96 | 102 | 52791 | 29367 | 79662128 |
| Klebsiella infection | 85.43 | 14.96 | 76 | 52817 | 15644 | 79675851 |
| Therapeutic product effect decreased | 85.41 | 14.96 | 6 | 52887 | 163857 | 79527638 |
| Cholestasis | 84.96 | 14.96 | 136 | 52757 | 51973 | 79639522 |
| Sinusitis | 84.64 | 14.96 | 14 | 52879 | 195487 | 79496008 |
| Infusion related reaction | 84.46 | 14.96 | 24 | 52869 | 230213 | 79461282 |
| Tooth discolouration | 84.44 | 14.96 | 31 | 52862 | 1126 | 79690369 |
| Aspergillus infection | 83.64 | 14.96 | 82 | 52811 | 19079 | 79672416 |
| Synovitis | 83.19 | 14.96 | 4 | 52889 | 150730 | 79540765 |
| Sideroblastic anaemia | 83.15 | 14.96 | 22 | 52871 | 259 | 79691236 |
| Pain in extremity | 82.84 | 14.96 | 72 | 52821 | 364466 | 79327029 |
| Peripheral swelling | 82.16 | 14.96 | 38 | 52855 | 269579 | 79421916 |
| Back pain | 80.84 | 14.96 | 51 | 52842 | 304129 | 79387366 |
| Aplasia pure red cell | 80.14 | 14.96 | 55 | 52838 | 7755 | 79683740 |
| Leukopenia | 78.38 | 14.96 | 211 | 52682 | 116302 | 79575193 |
| Renal impairment | 76.97 | 14.96 | 255 | 52638 | 157528 | 79533967 |
| Malaise | 75.28 | 14.96 | 131 | 52762 | 489738 | 79201757 |
| Injection site pain | 73.11 | 14.96 | 3 | 52890 | 129835 | 79561660 |
| Dizziness | 72.81 | 14.96 | 150 | 52743 | 526291 | 79165204 |
| Alveolar lung disease | 71.60 | 14.96 | 23 | 52870 | 554 | 79690941 |
| Renal failure | 71.30 | 14.96 | 293 | 52600 | 200675 | 79490820 |
| Swelling | 70.07 | 14.96 | 28 | 52865 | 216683 | 79474812 |
| Contusion | 68.21 | 14.96 | 9 | 52884 | 148767 | 79542728 |
| Skin candida | 66.77 | 14.96 | 31 | 52862 | 2056 | 79689439 |
| Alopecia | 63.95 | 14.96 | 37 | 52856 | 231318 | 79460177 |
| Intraocular pressure increased | 63.38 | 14.96 | 51 | 52842 | 9154 | 79682341 |
| Hepatic failure | 63.13 | 14.96 | 131 | 52762 | 61081 | 79630414 |
| Metabolic acidosis | 62.21 | 14.96 | 156 | 52737 | 82373 | 79609122 |
| Eosinophilic pneumonia | 60.73 | 14.96 | 40 | 52853 | 5270 | 79686225 |
| Haematotoxicity | 59.65 | 14.96 | 62 | 52831 | 15457 | 79676038 |
| Musculoskeletal stiffness | 59.26 | 14.96 | 21 | 52872 | 174987 | 79516508 |
| Differentiation syndrome | 58.26 | 14.96 | 30 | 52863 | 2494 | 79689001 |
| Clostridium difficile colitis | 57.83 | 14.96 | 88 | 52805 | 32195 | 79659300 |
| Minimum inhibitory concentration | 57.62 | 14.96 | 15 | 52878 | 165 | 79691330 |
| Incorrect product administration duration | 57.29 | 14.96 | 54 | 52839 | 11968 | 79679527 |
| Multiple-drug resistance | 56.86 | 14.96 | 47 | 52846 | 8761 | 79682734 |
| Hepatic cytolysis | 55.85 | 14.96 | 79 | 52814 | 27072 | 79664423 |
| Uveitis | 55.49 | 14.96 | 62 | 52831 | 16768 | 79674727 |
| Hepatocellular injury | 55.24 | 14.96 | 107 | 52786 | 47486 | 79644009 |
| Dysbiosis | 54.82 | 14.96 | 23 | 52870 | 1196 | 79690299 |
| Cough | 54.57 | 14.96 | 100 | 52793 | 366689 | 79324806 |
| Toxic epidermal necrolysis | 53.92 | 14.96 | 102 | 52791 | 44479 | 79647016 |
| Hypersensitivity vasculitis | 53.26 | 14.96 | 41 | 52852 | 6902 | 79684593 |
| Bronchitis | 53.00 | 14.96 | 11 | 52882 | 130633 | 79560862 |
| Mobility decreased | 52.31 | 14.96 | 9 | 52884 | 122166 | 79569329 |
| Tongue discolouration | 52.30 | 14.96 | 32 | 52861 | 3711 | 79687784 |
| Cardiac valve vegetation | 50.43 | 14.96 | 20 | 52873 | 899 | 79690596 |
| Pulmonary interstitial emphysema syndrome | 49.51 | 14.96 | 17 | 52876 | 506 | 79690989 |
| Hepatitis cholestatic | 49.08 | 14.96 | 53 | 52840 | 13799 | 79677696 |
| Encephalopathy | 48.30 | 14.96 | 125 | 52768 | 67272 | 79624223 |
| Hypomagnesaemia | 46.74 | 14.96 | 99 | 52794 | 46812 | 79644683 |
| Drug-induced liver injury | 46.74 | 14.96 | 122 | 52771 | 65995 | 79625500 |
| Tuberculosis | 46.73 | 14.96 | 54 | 52839 | 15144 | 79676351 |
| Brain abscess | 46.53 | 14.96 | 33 | 52860 | 4903 | 79686592 |
| Impaired healing | 46.28 | 14.96 | 3 | 52890 | 87652 | 79603843 |
| Pseudomonas infection | 46.26 | 14.96 | 63 | 52830 | 20840 | 79670655 |
| Discomfort | 46.22 | 14.96 | 13 | 52880 | 125604 | 79565891 |
| Memory impairment | 46.18 | 14.96 | 9 | 52884 | 111725 | 79579770 |
| Migraine | 46.17 | 14.96 | 3 | 52890 | 87490 | 79604005 |
| Shock | 45.84 | 14.96 | 94 | 52799 | 43454 | 79648041 |
| Drug ineffective | 45.51 | 14.96 | 985 | 51908 | 1079928 | 78611567 |
| Blood disorder | 44.96 | 14.96 | 40 | 52853 | 8233 | 79683262 |
| Pneumothorax | 44.90 | 14.96 | 73 | 52820 | 28250 | 79663245 |
| Toxic skin eruption | 44.58 | 14.96 | 64 | 52829 | 22229 | 79669266 |
| Transaminases increased | 44.56 | 14.96 | 103 | 52790 | 51640 | 79639855 |
| Deafness | 44.44 | 14.96 | 62 | 52831 | 20975 | 79670520 |
| Hypolipidaemia | 44.23 | 14.96 | 7 | 52886 | 0 | 79691495 |
| Mucormycosis | 44.15 | 14.96 | 40 | 52853 | 8429 | 79683066 |
| Hyperbilirubinaemia | 44.15 | 14.96 | 67 | 52826 | 24451 | 79667044 |
| Reticulocytopenia | 44.13 | 14.96 | 13 | 52880 | 232 | 79691263 |
| Muscle spasms | 44.08 | 14.96 | 31 | 52862 | 174699 | 79516796 |
| Deafness neurosensory | 42.85 | 14.96 | 36 | 52857 | 6862 | 79684633 |
| Wound | 42.78 | 14.96 | 12 | 52881 | 116167 | 79575328 |
| Acute respiratory distress syndrome | 42.76 | 14.96 | 92 | 52801 | 43975 | 79647520 |
| Haemophagocytic lymphohistiocytosis | 42.66 | 14.96 | 62 | 52831 | 21775 | 79669720 |
| Systemic lupus erythematosus | 41.93 | 14.96 | 14 | 52879 | 121135 | 79570360 |
| Mixed liver injury | 41.90 | 14.96 | 37 | 52856 | 7541 | 79683954 |
| Feeling abnormal | 41.83 | 14.96 | 27 | 52866 | 159172 | 79532323 |
| Gastrooesophageal reflux disease | 41.83 | 14.96 | 9 | 52884 | 104237 | 79587258 |
| Pericarditis | 41.82 | 14.96 | 9 | 52884 | 104227 | 79587268 |
| Therapeutic product effect incomplete | 41.54 | 14.96 | 21 | 52872 | 141624 | 79549871 |
| Contraindicated product administered | 41.01 | 14.96 | 27 | 52866 | 157511 | 79533984 |
| Drug dispensed to wrong patient | 40.97 | 14.96 | 16 | 52877 | 690 | 79690805 |
| Drug level decreased | 40.68 | 14.96 | 49 | 52844 | 14353 | 79677142 |
| Infective pulmonary exacerbation of cystic fibrosis | 40.08 | 14.96 | 46 | 52847 | 12805 | 79678690 |
| Blood pressure increased | 39.76 | 14.96 | 49 | 52844 | 211311 | 79480184 |
| Psoriasis | 39.69 | 14.96 | 6 | 52887 | 89581 | 79601914 |
| Bacteraemia | 39.57 | 14.96 | 75 | 52818 | 32749 | 79658746 |
| Myoclonus | 39.46 | 14.96 | 68 | 52825 | 27592 | 79663903 |
| Glossodynia | 39.33 | 14.96 | 10 | 52883 | 103327 | 79588168 |
| Pruritus | 38.87 | 14.96 | 133 | 52760 | 394515 | 79296980 |
| Neck pain | 38.60 | 14.96 | 3 | 52890 | 75414 | 79616081 |
| Pancreatitis haemorrhagic | 38.46 | 14.96 | 16 | 52877 | 814 | 79690681 |
| Nervous system disorder | 38.28 | 14.96 | 66 | 52827 | 26790 | 79664705 |
| Insomnia | 38.10 | 14.96 | 65 | 52828 | 245105 | 79446390 |
| Enterococcus test positive | 37.34 | 14.96 | 21 | 52872 | 2083 | 79689412 |
| Acinetobacter infection | 36.91 | 14.96 | 23 | 52870 | 2754 | 79688741 |
| Musculoskeletal pain | 36.90 | 14.96 | 11 | 52882 | 102343 | 79589152 |
| Abdominal discomfort | 36.69 | 14.96 | 69 | 52824 | 250658 | 79440837 |
| Therapeutic response delayed | 36.65 | 14.96 | 17 | 52876 | 1125 | 79690370 |
| Pancreatitis acute | 36.57 | 14.96 | 93 | 52800 | 49511 | 79641984 |
| Rhinorrhoea | 36.34 | 14.96 | 4 | 52889 | 76070 | 79615425 |
| Hepatitis acute | 36.16 | 14.96 | 48 | 52845 | 15494 | 79676001 |
| Aortoenteric fistula | 36.01 | 14.96 | 10 | 52883 | 143 | 79691352 |
| Rash morbilliform | 35.96 | 14.96 | 31 | 52862 | 6119 | 79685376 |
| Cytopenia | 35.71 | 14.96 | 55 | 52838 | 20328 | 79671167 |
| Staphylococcal bacteraemia | 35.22 | 14.96 | 42 | 52851 | 12176 | 79679319 |
| Chest pain | 35.22 | 14.96 | 85 | 52808 | 282219 | 79409276 |
| Inappropriate schedule of product administration | 34.65 | 14.96 | 23 | 52870 | 133605 | 79557890 |
| Malignant neoplasm progression | 34.47 | 14.96 | 24 | 52869 | 135966 | 79555529 |
| Hypokalaemia | 34.20 | 14.96 | 187 | 52706 | 143853 | 79547642 |
| Agranulocytosis | 33.80 | 14.96 | 85 | 52808 | 44945 | 79646550 |
| Blood pressure fluctuation | 33.46 | 14.96 | 3 | 52890 | 67142 | 79624353 |
| Stomatitis | 33.27 | 14.96 | 29 | 52864 | 146728 | 79544767 |
| Myocardial infarction | 33.27 | 14.96 | 44 | 52849 | 184085 | 79507410 |
| Endocarditis | 33.17 | 14.96 | 38 | 52855 | 10559 | 79680936 |
| CNS ventriculitis | 32.94 | 14.96 | 12 | 52881 | 426 | 79691069 |
| Neurotoxicity | 32.83 | 14.96 | 69 | 52824 | 32449 | 79659046 |
| Meningitis tuberculous | 32.75 | 14.96 | 16 | 52877 | 1189 | 79690306 |
| Respiratory distress | 32.73 | 14.96 | 99 | 52794 | 58240 | 79633255 |
| Fluid retention | 32.52 | 14.96 | 4 | 52889 | 69805 | 79621690 |
| Syncope | 32.30 | 14.96 | 43 | 52850 | 179406 | 79512089 |
| Blood lactic acid increased | 32.21 | 14.96 | 41 | 52852 | 12703 | 79678792 |
| Maternal exposure during pregnancy | 32.16 | 14.96 | 26 | 52867 | 136512 | 79554983 |
| Nasal congestion | 31.98 | 14.96 | 6 | 52887 | 76546 | 79614949 |
| Nocardiosis | 31.94 | 14.96 | 28 | 52865 | 5651 | 79685844 |
| Stress | 31.68 | 14.96 | 7 | 52886 | 79605 | 79611890 |
| Urinary tract infection | 31.66 | 14.96 | 86 | 52807 | 274426 | 79417069 |
| Diabetic macroangiopathy | 31.53 | 14.96 | 9 | 52884 | 143 | 79691352 |
| Pulmonary mucormycosis | 30.26 | 14.96 | 15 | 52878 | 1150 | 79690345 |
| Hepatitis toxic | 30.21 | 14.96 | 26 | 52867 | 5121 | 79686374 |
| Peripheral sensory neuropathy | 29.93 | 14.96 | 40 | 52853 | 12993 | 79678502 |
| Anxiety | 29.30 | 14.96 | 77 | 52816 | 248435 | 79443060 |
| Red blood cell vacuolisation | 29.25 | 14.96 | 5 | 52888 | 3 | 79691492 |
| Organ failure | 29.16 | 14.96 | 23 | 52870 | 4010 | 79687485 |
| Vascular pseudoaneurysm thrombosis | 29.11 | 14.96 | 7 | 52886 | 54 | 79691441 |
| Hypoglycaemia | 29.08 | 14.96 | 139 | 52754 | 101455 | 79590040 |
| Asthma | 29.07 | 14.96 | 28 | 52865 | 135067 | 79556428 |
| Optic nerve disorder | 28.96 | 14.96 | 15 | 52878 | 1262 | 79690233 |
| Hypersensitivity | 28.87 | 14.96 | 84 | 52809 | 262155 | 79429340 |
| Blood creatine phosphokinase increased | 28.86 | 14.96 | 103 | 52790 | 65987 | 79625508 |
| Dyspnoea | 28.86 | 14.96 | 398 | 52495 | 856627 | 78834868 |
| Injury | 28.54 | 14.96 | 8 | 52885 | 77488 | 79614007 |
| Oedematous kidney | 28.37 | 14.96 | 9 | 52884 | 208 | 79691287 |
| Cholangiolitis | 28.27 | 14.96 | 6 | 52887 | 24 | 79691471 |
| Eosinophilic pneumonia acute | 28.12 | 14.96 | 14 | 52879 | 1084 | 79690411 |
| Wheezing | 27.74 | 14.96 | 22 | 52871 | 116642 | 79574853 |
| Hyponatraemia | 27.44 | 14.96 | 207 | 52686 | 177641 | 79513854 |
| Hepatitis | 27.08 | 14.96 | 90 | 52803 | 55637 | 79635858 |
| Diffuse alveolar damage | 27.03 | 14.96 | 21 | 52872 | 3583 | 79687912 |
| Oropharyngeal pain | 26.79 | 14.96 | 20 | 52873 | 109333 | 79582162 |
| Pancreatitis | 26.70 | 14.96 | 103 | 52790 | 68472 | 79623023 |
| Rhabdomyolysis | 26.60 | 14.96 | 137 | 52756 | 102994 | 79588501 |
| Paradoxical drug reaction | 26.35 | 14.96 | 28 | 52865 | 7157 | 79684338 |
| Normocytic anaemia | 26.22 | 14.96 | 22 | 52871 | 4185 | 79687310 |
| Peripheral motor neuropathy | 26.08 | 14.96 | 20 | 52873 | 3347 | 79688148 |
| Flushing | 26.00 | 14.96 | 13 | 52880 | 88255 | 79603240 |
| Somnolence | 25.98 | 14.96 | 77 | 52816 | 238904 | 79452591 |
| Cardiopulmonary failure | 25.83 | 14.96 | 27 | 52866 | 6774 | 79684721 |
| Ill-defined disorder | 25.79 | 14.96 | 6 | 52887 | 65869 | 79625626 |
| Hallucination | 25.77 | 14.96 | 119 | 52774 | 85626 | 79605869 |
| Hypocapnia | 25.18 | 14.96 | 11 | 52882 | 632 | 79690863 |
| Hypofibrinogenaemia | 25.15 | 14.96 | 16 | 52877 | 1986 | 79689509 |
| Weight decreased | 24.96 | 14.96 | 136 | 52757 | 355062 | 79336433 |
| Pericarditis tuberculous | 24.96 | 14.96 | 7 | 52886 | 104 | 79691391 |
| Erythropoiesis abnormal | 24.91 | 14.96 | 10 | 52883 | 464 | 79691031 |
| Rectal perforation | 24.55 | 14.96 | 12 | 52881 | 893 | 79690602 |
| Posterior reversible encephalopathy syndrome | 24.50 | 14.96 | 54 | 52839 | 26227 | 79665268 |
| Arthritis | 24.50 | 14.96 | 24 | 52869 | 114856 | 79576639 |
| Generalised tonic-clonic seizure | 24.15 | 14.96 | 74 | 52819 | 43836 | 79647659 |
| Purpura | 24.01 | 14.96 | 45 | 52848 | 19482 | 79672013 |
| Pneumonia necrotising | 23.84 | 14.96 | 13 | 52880 | 1214 | 79690281 |
| Mediastinal effusion | 23.75 | 14.96 | 6 | 52887 | 58 | 79691437 |
| Antibiotic level above therapeutic | 23.70 | 14.96 | 11 | 52882 | 729 | 79690766 |
| Acid base balance abnormal | 23.62 | 14.96 | 9 | 52884 | 363 | 79691132 |
| Influenza like illness | 23.59 | 14.96 | 9 | 52884 | 71698 | 79619797 |
| Hyperleukocytosis | 23.57 | 14.96 | 17 | 52876 | 2593 | 79688902 |
| Leuconostoc infection | 23.56 | 14.96 | 5 | 52888 | 20 | 79691475 |
| SJS-TEN overlap | 23.43 | 14.96 | 11 | 52882 | 748 | 79690747 |
| Herpes zoster meningoencephalitis | 23.40 | 14.96 | 11 | 52882 | 750 | 79690745 |
| Influenza | 23.38 | 14.96 | 31 | 52862 | 129575 | 79561920 |
| Otitis media fungal | 23.37 | 14.96 | 5 | 52888 | 21 | 79691474 |
| Cerebrovascular accident | 23.36 | 14.96 | 42 | 52851 | 155250 | 79536245 |
| Enterococcal bacteraemia | 23.28 | 14.96 | 18 | 52875 | 3050 | 79688445 |
| Suicide attempt | 23.27 | 14.96 | 13 | 52880 | 82919 | 79608576 |
| Eye pain | 23.21 | 14.96 | 66 | 52827 | 37512 | 79653983 |
| Botulism | 23.18 | 14.96 | 9 | 52884 | 382 | 79691113 |
| Wound dehiscence | 22.96 | 14.96 | 25 | 52868 | 6570 | 79684925 |
| Blood fibrinogen decreased | 22.86 | 14.96 | 15 | 52878 | 1964 | 79689531 |
| Muscular weakness | 22.83 | 14.96 | 45 | 52848 | 160684 | 79530811 |
| Enterobacter infection | 22.71 | 14.96 | 21 | 52872 | 4541 | 79686954 |
| Osteoarthritis | 22.67 | 14.96 | 15 | 52878 | 87294 | 79604201 |
| Cognitive disorder | 22.64 | 14.96 | 9 | 52884 | 69917 | 79621578 |
| Pulmonary tuberculosis | 22.61 | 14.96 | 27 | 52866 | 7838 | 79683657 |
| Haemodynamic instability | 22.55 | 14.96 | 41 | 52852 | 17341 | 79674154 |
| Stevens-Johnson syndrome | 22.47 | 14.96 | 67 | 52826 | 39099 | 79652396 |
| Immune reconstitution inflammatory syndrome associated tuberculosis | 22.42 | 14.96 | 11 | 52882 | 825 | 79690670 |
| Axonal neuropathy | 22.35 | 14.96 | 15 | 52878 | 2039 | 79689456 |
| Intentional product use issue | 22.32 | 14.96 | 175 | 52718 | 151937 | 79539558 |
| Disseminated tuberculosis | 22.28 | 14.96 | 20 | 52873 | 4163 | 79687332 |
| Respiratory gas exchange disorder | 22.23 | 14.96 | 11 | 52882 | 840 | 79690655 |
| Blood bilirubin increased | 22.23 | 14.96 | 95 | 52798 | 66137 | 79625358 |
| Nutritional condition abnormal | 22.16 | 14.96 | 12 | 52881 | 1105 | 79690390 |
| Hypertension | 22.03 | 14.96 | 129 | 52764 | 330863 | 79360632 |
| Confusional state | 21.97 | 14.96 | 314 | 52579 | 317683 | 79373812 |
| Vomiting | 21.01 | 14.96 | 584 | 52309 | 665244 | 79026251 |
| Drug intolerance | 20.90 | 14.96 | 97 | 52796 | 264022 | 79427473 |
| Toxic neuropathy | 20.77 | 14.96 | 11 | 52882 | 969 | 79690526 |
| Depression | 20.68 | 14.96 | 74 | 52819 | 216716 | 79474779 |
| Condition aggravated | 20.40 | 14.96 | 455 | 52438 | 500669 | 79190826 |
| Angular cheilitis | 20.36 | 14.96 | 10 | 52883 | 752 | 79690743 |
| Metastases to muscle | 20.33 | 14.96 | 8 | 52885 | 352 | 79691143 |
| Orthostatic hypotension | 20.31 | 14.96 | 6 | 52887 | 56158 | 79635337 |
| Escherichia infection | 20.28 | 14.96 | 40 | 52853 | 17977 | 79673518 |
| Coronary artery disease | 20.27 | 14.96 | 9 | 52884 | 65465 | 79626030 |
| Nephropathy toxic | 20.23 | 14.96 | 43 | 52850 | 20376 | 79671119 |
| Generalised oedema | 20.19 | 14.96 | 47 | 52846 | 23662 | 79667833 |
| Splenic infection fungal | 20.17 | 14.96 | 6 | 52887 | 111 | 79691384 |
| Intentional product misuse | 20.15 | 14.96 | 20 | 52873 | 95145 | 79596350 |
| Infectious pleural effusion | 20.14 | 14.96 | 18 | 52875 | 3726 | 79687769 |
| Cataract | 20.10 | 14.96 | 8 | 52885 | 62112 | 79629383 |
| Bone pain | 20.07 | 14.96 | 6 | 52887 | 55736 | 79635759 |
| Immune effector cell-associated neurotoxicity syndrome | 20.06 | 14.96 | 22 | 52871 | 5826 | 79685669 |
| Dry skin | 20.05 | 14.96 | 10 | 52883 | 67985 | 79623510 |
| Clostridium test positive | 19.96 | 14.96 | 23 | 52870 | 6431 | 79685064 |
| Vestibular disorder | 19.94 | 14.96 | 15 | 52878 | 2440 | 79689055 |
| Folliculitis | 19.87 | 14.96 | 6 | 52887 | 55374 | 79636121 |
| Intervertebral discitis | 19.84 | 14.96 | 20 | 52873 | 4808 | 79686687 |
| Thrombosis | 19.82 | 14.96 | 16 | 52877 | 84084 | 79607411 |
| Pseudomembranous colitis | 19.81 | 14.96 | 21 | 52872 | 5353 | 79686142 |
| Oedema peripheral | 19.76 | 14.96 | 93 | 52800 | 252195 | 79439300 |
| Pulmonary function test | 19.74 | 14.96 | 4 | 52889 | 12 | 79691483 |
| Exfoliative rash | 19.67 | 14.96 | 18 | 52875 | 3841 | 79687654 |
| Hypoacusis | 19.65 | 14.96 | 54 | 52839 | 30096 | 79661399 |
| Portal vein cavernous transformation | 19.54 | 14.96 | 6 | 52887 | 124 | 79691371 |
| Aplasia | 19.51 | 14.96 | 25 | 52868 | 7795 | 79683700 |
| Myasthenia gravis crisis | 19.47 | 14.96 | 11 | 52882 | 1100 | 79690395 |
| Metastases to retroperitoneum | 19.44 | 14.96 | 8 | 52885 | 396 | 79691099 |
| Respiratory arrest | 19.31 | 14.96 | 7 | 52886 | 57543 | 79633952 |
| Relapsing fever | 19.23 | 14.96 | 8 | 52885 | 407 | 79691088 |
| Transaminases abnormal | 19.19 | 14.96 | 10 | 52883 | 852 | 79690643 |
| Inappropriate antidiuretic hormone secretion | 19.05 | 14.96 | 49 | 52844 | 26264 | 79665231 |
| Acute myocardial infarction | 18.98 | 14.96 | 14 | 52879 | 77022 | 79614473 |
| Oedematous pancreatitis | 18.96 | 14.96 | 11 | 52882 | 1157 | 79690338 |
| Knee arthroplasty | 18.92 | 14.96 | 3 | 52890 | 43245 | 79648250 |
| Cardiac disorder | 18.90 | 14.96 | 10 | 52883 | 65747 | 79625748 |
| Reticulocyte count decreased | 18.64 | 14.96 | 10 | 52883 | 904 | 79690591 |
| Hepatic infarction | 18.63 | 14.96 | 10 | 52883 | 905 | 79690590 |
| Flatulence | 18.61 | 14.96 | 3 | 52890 | 42721 | 79648774 |
| Enterocolitis | 18.54 | 14.96 | 34 | 52859 | 14478 | 79677017 |
| Haemoglobin decreased | 18.52 | 14.96 | 227 | 52666 | 221892 | 79469603 |
| Status epilepticus | 18.51 | 14.96 | 47 | 52846 | 24994 | 79666501 |
| Pain in jaw | 18.48 | 14.96 | 4 | 52889 | 46147 | 79645348 |
| Constipation | 18.46 | 14.96 | 111 | 52782 | 282939 | 79408556 |
| Cutaneous vasculitis | 18.45 | 14.96 | 25 | 52868 | 8227 | 79683268 |
| Pyelonephritis chronic | 18.33 | 14.96 | 7 | 52886 | 284 | 79691211 |
| Staphylococcus test positive | 18.22 | 14.96 | 22 | 52871 | 6459 | 79685036 |
| Blood pressure systolic increased | 18.09 | 14.96 | 11 | 52882 | 66975 | 79624520 |
| Myalgia | 17.95 | 14.96 | 63 | 52830 | 185578 | 79505917 |
| Depressed mood | 17.86 | 14.96 | 5 | 52888 | 48475 | 79643020 |
| Neoplasm progression | 17.83 | 14.96 | 6 | 52887 | 51676 | 79639819 |
| Abdominal pain upper | 17.83 | 14.96 | 82 | 52811 | 223737 | 79467758 |
| Cholecystitis acute | 17.80 | 14.96 | 32 | 52861 | 13419 | 79678076 |
| Cystic fibrosis | 17.67 | 14.96 | 17 | 52876 | 3863 | 79687632 |
| Splenic necrosis | 17.66 | 14.96 | 6 | 52887 | 173 | 79691322 |
| Presyncope | 17.62 | 14.96 | 3 | 52890 | 41051 | 79650444 |
| Bilirubin conjugated increased | 17.57 | 14.96 | 20 | 52873 | 5519 | 79685976 |
| Neutropenia | 17.50 | 14.96 | 278 | 52615 | 287432 | 79404063 |
| Chorioretinitis | 17.43 | 14.96 | 10 | 52883 | 1030 | 79690465 |
| Aspartate aminotransferase increased | 17.40 | 14.96 | 154 | 52739 | 138487 | 79553008 |
| Shock haemorrhagic | 17.34 | 14.96 | 40 | 52853 | 20020 | 79671475 |
| Dysphonia | 17.32 | 14.96 | 8 | 52885 | 56864 | 79634631 |
| Anuria | 17.25 | 14.96 | 41 | 52852 | 20922 | 79670573 |
| Drug level fluctuating | 17.24 | 14.96 | 9 | 52884 | 770 | 79690725 |
| Product prescribing issue | 17.07 | 14.96 | 17 | 52876 | 4028 | 79687467 |
| Loss of personal independence in daily activities | 17.04 | 14.96 | 26 | 52867 | 102554 | 79588941 |
| Heart rate decreased | 17.04 | 14.96 | 13 | 52880 | 70303 | 79621192 |
| Visual impairment | 16.99 | 14.96 | 112 | 52781 | 92019 | 79599476 |
| Pulmonary haemorrhage | 16.96 | 14.96 | 33 | 52860 | 14684 | 79676811 |
| Hallucination, visual | 16.93 | 14.96 | 54 | 52839 | 32675 | 79658820 |
| Herbal toxicity | 16.85 | 14.96 | 4 | 52889 | 29 | 79691466 |
| Metastases to bone marrow | 16.78 | 14.96 | 9 | 52884 | 813 | 79690682 |
| Accidental overdose | 16.75 | 14.96 | 3 | 52890 | 39578 | 79651917 |
| Systemic mycosis | 16.74 | 14.96 | 14 | 52879 | 2652 | 79688843 |
| Distributive shock | 16.64 | 14.96 | 14 | 52879 | 2673 | 79688822 |
| Tuberculoma of central nervous system | 16.57 | 14.96 | 8 | 52885 | 579 | 79690916 |
| Gait disturbance | 16.54 | 14.96 | 76 | 52817 | 207430 | 79484065 |
| Toxic leukoencephalopathy | 16.47 | 14.96 | 10 | 52883 | 1144 | 79690351 |
| Product use issue | 16.45 | 14.96 | 212 | 52681 | 209610 | 79481885 |
| Diverticulitis | 16.44 | 14.96 | 5 | 52888 | 45931 | 79645564 |
| Night sweats | 16.39 | 14.96 | 7 | 52886 | 52088 | 79639407 |
| Mediastinitis | 16.36 | 14.96 | 9 | 52884 | 855 | 79690640 |
| Extradural abscess | 16.35 | 14.96 | 11 | 52882 | 1501 | 79689994 |
| Procalcitonin decreased | 16.35 | 14.96 | 5 | 52888 | 102 | 79691393 |
| Enterovesical fistula | 16.24 | 14.96 | 10 | 52883 | 1172 | 79690323 |
| Upper respiratory tract infection | 16.24 | 14.96 | 22 | 52871 | 91146 | 79600349 |
| Angina pectoris | 16.19 | 14.96 | 7 | 52886 | 51725 | 79639770 |
| Tubulointerstitial nephritis | 16.19 | 14.96 | 59 | 52834 | 38176 | 79653319 |
| Electrolyte imbalance | 16.02 | 14.96 | 51 | 52842 | 30830 | 79660665 |
| Mycobacterium abscessus infection | 15.94 | 14.96 | 10 | 52883 | 1212 | 79690283 |
| Metastases to spleen | 15.87 | 14.96 | 8 | 52885 | 636 | 79690859 |
| Acute hepatic failure | 15.86 | 14.96 | 50 | 52843 | 30063 | 79661432 |
| Feeling hot | 15.86 | 14.96 | 10 | 52883 | 59724 | 79631771 |
| Dehydration | 15.83 | 14.96 | 98 | 52795 | 248089 | 79443406 |
| Mycobacterium chelonae infection | 15.63 | 14.96 | 13 | 52880 | 2443 | 79689052 |
| Disseminated strongyloidiasis | 15.54 | 14.96 | 6 | 52887 | 251 | 79691244 |
| Drug eruption | 15.50 | 14.96 | 64 | 52829 | 43871 | 79647624 |
| Hyperammonaemia | 15.46 | 14.96 | 27 | 52866 | 11066 | 79680429 |
| Atrial fibrillation | 15.46 | 14.96 | 73 | 52820 | 197813 | 79493682 |
| Cardiac failure congestive | 15.38 | 14.96 | 46 | 52847 | 142356 | 79549139 |
| Benign soft tissue neoplasm | 15.31 | 14.96 | 5 | 52888 | 127 | 79691368 |
| Hyperalbuminaemia | 15.28 | 14.96 | 4 | 52889 | 45 | 79691450 |
| Full blood count abnormal | 15.24 | 14.96 | 4 | 52889 | 40470 | 79651025 |
| Butterfly rash | 15.21 | 14.96 | 11 | 52882 | 1685 | 79689810 |
| Unevaluable event | 15.19 | 14.96 | 9 | 52884 | 55576 | 79635919 |
| Transient ischaemic attack | 15.16 | 14.96 | 8 | 52885 | 52687 | 79638808 |
| Septal panniculitis | 15.09 | 14.96 | 5 | 52888 | 133 | 79691362 |
| Suicidal ideation | 15.09 | 14.96 | 17 | 52876 | 76323 | 79615172 |
| Drug level increased | 14.98 | 14.96 | 59 | 52834 | 39592 | 79651903 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01XX08 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER ANTIBACTERIALS Other antibacterials |
| FDA CS | M0361132 | Oxazolidinones |
| FDA EPC | N0000175495 | Oxazolidinone Antibacterial |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D011500 | Protein Synthesis Inhibitors |
| CHEBI has role | CHEBI:36047 | antibacterial drugs |
| CHEBI has role | CHEBI:48001 | protein synthesis inhibitors |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Staphylococcal pneumonia | indication | 22754005 | |
| Pneumonia due to Streptococcus | indication | 34020007 | |
| Vancomycin resistant enterococcus | indication | 113727004 | |
| Streptococcus pyogenes infection | indication | 302809008 | |
| Infection due to Staphylococcus aureus | indication | 406602003 | |
| Complicated Skin and Skin Structure Staphylococcus Aureus Infection | indication | ||
| Diabetic Foot Infection Due to Gram-Positive Bacteria | indication | ||
| Complicated Skin and Skin Structure Streptococcus Agalactiae Infection | indication | ||
| Complicated Skin and Skin Structure Streptococcus Pyogenes Infection | indication | ||
| Vancomycin-Resistant Enterococcus Faecium Infection | indication | ||
| Pyrexia of unknown origin | off-label use | 7520000 | |
| Infection of bone | off-label use | 111253001 | |
| Carcinoid syndrome | contraindication | 35868009 | |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Disorder of optic nerve | contraindication | 77157004 | DOID:1891 |
| Leukopenia | contraindication | 84828003 | DOID:615 |
| Thyrotoxicosis | contraindication | 90739004 | DOID:7997 |
| Lactic acidosis | contraindication | 91273001 | DOID:3650 |
| Pancytopenia | contraindication | 127034005 | DOID:12450 |
| Seizure disorder | contraindication | 128613002 | |
| Anemia | contraindication | 271737000 | DOID:2355 |
| Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
| Peripheral nerve disease | contraindication | 302226006 | |
| Pheochromocytoma | contraindication | 302835009 | |
| Bone marrow depression | contraindication | 307762000 | |
| Serotonin syndrome | contraindication | 371089000 | |
| Visual impairment | contraindication | 397540003 | |
| Pseudomembranous enterocolitis | contraindication | 397683000 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 11.4 | acidic |
| pKa2 | 1.59 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Amine oxidase [flavin-containing] B | Enzyme | Ki | 4.50 | WOMBAT-PK | |||||
| Amine oxidase [flavin-containing] A | Enzyme | Ki | 5.10 | CHEMBL | |||||
| Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | Enzyme | IC50 | 5.09 | CHEMBL | |||||
| Amine oxidase [flavin-containing] B | Enzyme | IC50 | 4.77 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4021218 | VUID |
| N0000148664 | NUI |
| D00947 | KEGG_DRUG |
| 4021218 | VANDF |
| C0663241 | UMLSCUI |
| CHEBI:63607 | CHEBI |
| ZLD | PDB_CHEM_ID |
| CHEMBL126 | ChEMBL_ID |
| DB00601 | DRUGBANK_ID |
| D000069349 | MESH_DESCRIPTOR_UI |
| 441401 | PUBCHEM_CID |
| 10827 | IUPHAR_LIGAND_ID |
| 7584 | INN_ID |
| ISQ9I6J12J | UNII |
| 190376 | RXNORM |
| 229070 | MMSL |
| 31932 | MMSL |
| 8840 | MMSL |
| d04534 | MMSL |
| 008223 | NDDF |
| 125695009 | SNOMEDCT_US |
| 387056004 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Zyvox | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-4992 | INJECTION, SOLUTION | 600 mg | INTRAVENOUS | NDA | 32 sections |
| Zyvox | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-4992 | INJECTION, SOLUTION | 600 mg | INTRAVENOUS | NDA | 32 sections |
| Zyvox | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-5136 | GRANULE, FOR SUSPENSION | 100 mg | ORAL | NDA | 32 sections |
| Zyvox | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-5136 | GRANULE, FOR SUSPENSION | 100 mg | ORAL | NDA | 32 sections |
| Zyvox | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-5137 | INJECTION, SOLUTION | 200 mg | INTRAVENOUS | NDA | 32 sections |
| Zyvox | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-5137 | INJECTION, SOLUTION | 200 mg | INTRAVENOUS | NDA | 32 sections |
| Zyvox | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-5138 | TABLET, FILM COATED | 600 mg | ORAL | NDA | 32 sections |
| Zyvox | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-5138 | TABLET, FILM COATED | 600 mg | ORAL | NDA | 32 sections |
| Zyvox | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-5140 | INJECTION, SOLUTION | 600 mg | INTRAVENOUS | NDA | 32 sections |
| Zyvox | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-5140 | INJECTION, SOLUTION | 600 mg | INTRAVENOUS | NDA | 32 sections |
| Zyvox | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-7807 | INJECTION, SOLUTION | 600 mg | INTRAVENOUS | NDA | 32 sections |
| Zyvox | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-7807 | INJECTION, SOLUTION | 600 mg | INTRAVENOUS | NDA | 32 sections |
| Linezolid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0319 | POWDER, FOR SUSPENSION | 100 mg | ORAL | ANDA | 27 sections |
| Linezolid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0319 | POWDER, FOR SUSPENSION | 100 mg | ORAL | ANDA | 27 sections |
| Linezolid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9534 | INJECTION, SOLUTION | 600 mg | INTRAVENOUS | ANDA | 29 sections |
| Linezolid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-4883 | INJECTION, SOLUTION | 2 mg | INTRAVENOUS | NDA | 30 sections |
| Linezolid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-4883 | INJECTION, SOLUTION | 2 mg | INTRAVENOUS | NDA | 30 sections |
| Linezolid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-4883 | INJECTION, SOLUTION | 2 mg | INTRAVENOUS | NDA | 30 sections |
| Linezolid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-3431 | INJECTION, SOLUTION | 200 mg | INTRAVENOUS | ANDA | 29 sections |
| Linezolid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-3433 | INJECTION, SOLUTION | 600 mg | INTRAVENOUS | ANDA | 29 sections |
| Linezolid | Human Prescription Drug Label | 1 | 0904-6553 | TABLET, FILM COATED | 600 mg | ORAL | ANDA | 28 sections |
| Zyvox | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-399 | TABLET, FILM COATED | 600 mg | ORAL | NDA | 28 sections |
| linezolid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-169 | INJECTION, SOLUTION | 2 mg | INTRAVENOUS | ANDA | 29 sections |
| Linezolid | Human Prescription Drug Label | 1 | 31722-749 | TABLET, FILM COATED | 600 mg | ORAL | ANDA | 27 sections |
| Linezolid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 31722-865 | GRANULE, FOR SUSPENSION | 100 mg | ORAL | ANDA | 28 sections |
| Linezolid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 40032-022 | TABLET | 600 mg | ORAL | ANDA | 26 sections |
| Linezolid | Human Prescription Drug Label | 1 | 46708-183 | TABLET, FILM COATED | 600 mg | ORAL | ANDA | 27 sections |
| Linezolid | Human Prescription Drug Label | 1 | 46708-183 | TABLET, FILM COATED | 600 mg | ORAL | ANDA | 27 sections |
| Linezolid | Human Prescription Drug Label | 1 | 55150-242 | INJECTION, SOLUTION | 600 mg | INTRAVENOUS | ANDA | 28 sections |
| Linezolid | Human Prescription Drug Label | 1 | 55150-242 | INJECTION, SOLUTION | 600 mg | INTRAVENOUS | ANDA | 28 sections |