lincomycin ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, produced by Streptomyces strains 1582 154-21-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • lincomycin
  • cillimycin
  • jiemycin
  • Lincomycin A
  • medoglycine
  • lincomycin hydrochloride
  • lincomycin HCl
  • lincomycin hydrochloride monohydrate
An antibiotic produced by Streptomyces lincolnensis var. lincolnensis. It has been used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections.
  • Molecular weight: 406.54
  • Formula: C18H34N2O6S
  • CLOGP: 1.28
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 5
  • TPSA: 122.49
  • ALOGS: -1.14
  • ROTB: 7

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1.80 g O
1.80 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 50 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 30 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 129.94 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 25 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.10 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5.60 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 29, 1964 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 239.31 65.54 68 120 310619 63178215

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 162.16 49.64 48 139 298868 79445333

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01FF02 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
Lincosamides
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011500 Protein Synthesis Inhibitors
CHEBI has role CHEBI:33281 antibiotics

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Pneumococcal infectious disease indication 16814004
Staphylococcal infectious disease indication 56038003
Streptococcal infectious disease indication 85769006
Disorder of digestive system contraindication 53619000 DOID:77
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Colitis contraindication 64226004 DOID:0060180
Pseudomembranous enterocolitis contraindication 397683000




๐Ÿถ Veterinary Drug Use

SpeciesUseRelation
Bees Control of American foulbrood (Paenibacillus larvae) Indication
Cats Infections caused by gram-positive organisms (streptococci and staphylococci) Indication
Chickens Control of airsacculitis caused by Mycoplasma synoviae Indication
Chickens Control of airsacculitis caused by Mycoplasma gallisepticum Indication
Chickens Complicated chronic respiratory disease (air sac infection) Indication
Chickens Necrotic enteritis caused or complicated by Clostridium spp Indication
Dogs Infections caused by gram-positive organisms (streptococci and staphylococci) Indication
Swine Dysentery (bloody scours) Indication
Swine Infectious arthritis Indication
Swine Mycoplasma pneumonia Indication
Swine Proliferative enteropathies (ileitis) caused by Lawsonia intracellularis Indication

๐Ÿถ Veterinary products

ProductApplicantIngredients
Lincocin Tablets Zoetis Inc. 1
Lincocin, Lincomix 25 Injectable, Lincomix 50 Injectable, Lincomix 100 Injectable, Lincomix 300 Injectable Zoetis Inc. 1
Lincocin Aquadrops Zoetis Inc. 1
L-S 50 Water Soluble Powder Zoetis Inc. 2
LINCOMIX 20, LINCOMIX 50 Zoetis Inc. 1
LINCOMIX Soluble Powder Zoetis Inc. 1
LINCOMIX and Banminth Phibro Animal Health Corp. 2
LINCOMIX and Banminth Zoetis Inc. 2
SAFE-GUARD plus LINCOMIX Intervet Inc. 2
Stenorol and LINCOMIX Huvepharma EOOD 2
Robenz and LINCOMIX Zoetis Inc. 2
Deccox and LINCOMIX Zoetis Inc. 2
Bio-Cox and LINCOMIX Zoetis Inc. 2
COYDEN and LINCOMIX Zoetis Inc. 2
Avatec and LINCOMIX Zoetis Inc. 2
Zoamix and LINCOMIX Zoetis Inc. 2
Coban and LINCOMIX Zoetis Inc. 2
Lincomycin Soluble Huvepharma EOOD 1
Linco Soluble Zoetis Inc. 1
Lincosol Soluble Powder Med-Pharmex Inc. 1
Lincomycin Injectable 30% Zoetis Inc. 1
Lincomycin Hydrochloride Soluble Powder Quo Vademus LLC 1
Lincomycin 100, Lincomycin 25, Lincomycin 300, Lincomycin Injection 100, Lincomycin Injection 25, Lincomycin Injection 300 Sparhawk Laboratories Inc. 1
Lincomycin - Spectinomycin Phibro Animal Health Corp. 2
Lincomycin Injectable, USP Huvepharma EOOD 1
LincoMed 100, LincoMed 300 Bimeda Animal Health Limited 1
LinxMed-SP Bimeda Animal Health Limited 1
SpecLinx-50 Bimeda Animal Health Limited 2
Lincomycin-Spectinomycin Water Soluble Powder Huvepharma EOOD 2

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.37 acidic
pKa2 13.98 acidic
pKa3 8.22 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
50S ribosomal protein L10 Ribosomal protein WOMBAT-PK

External reference:

IDSource
4019802 VUID
N0000147891 NUI
D00223 KEGG_DRUG
4018090 VANDF
4019802 VANDF
C0023726 UMLSCUI
CHEBI:6472 CHEBI
3QB PDB_CHEM_ID
CHEMBL1447 ChEMBL_ID
D008034 MESH_DESCRIPTOR_UI
DB01627 DRUGBANK_ID
3000540 PUBCHEM_CID
10941 IUPHAR_LIGAND_ID
1419 INN_ID
7179-49-9 SECONDARY_CAS_RN
BOD072YW0F UNII
6398 RXNORM
1950 MMSL
4979 MMSL
4980 MMSL
7112 MMSL
d00279 MMSL
002793 NDDF
004867 NDDF
18449009 SNOMEDCT_US
2596005 SNOMEDCT_US
372677003 SNOMEDCT_US
CHEMBL3989551 ChEMBL_ID
CHEMBL1201097 ChEMBL_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Lincocin HUMAN PRESCRIPTION DRUG LABEL 1 0009-0104 INJECTION, SOLUTION 300 mg INTRAMUSCULAR NDA 27 sections
Lincocin HUMAN PRESCRIPTION DRUG LABEL 1 0009-0104 INJECTION, SOLUTION 300 mg INTRAMUSCULAR NDA 27 sections
Lincocin HUMAN PRESCRIPTION DRUG LABEL 1 0009-0104 INJECTION, SOLUTION 300 mg INTRAMUSCULAR NDA 27 sections
Lincocin HUMAN PRESCRIPTION DRUG LABEL 1 0009-0104 INJECTION, SOLUTION 300 mg INTRAMUSCULAR NDA 27 sections
Lincocin HUMAN PRESCRIPTION DRUG LABEL 1 0009-0107 INJECTION, SOLUTION 300 mg INTRAMUSCULAR NDA 27 sections
Lincocin HUMAN PRESCRIPTION DRUG LABEL 1 0009-0107 INJECTION, SOLUTION 300 mg INTRAMUSCULAR NDA 27 sections
Lincocin HUMAN PRESCRIPTION DRUG LABEL 1 0009-0107 INJECTION, SOLUTION 300 mg INTRAMUSCULAR NDA 27 sections
Lincocin HUMAN PRESCRIPTION DRUG LABEL 1 0009-0107 INJECTION, SOLUTION 300 mg INTRAMUSCULAR NDA 27 sections
Lincocin HUMAN PRESCRIPTION DRUG LABEL 1 0009-0555 INJECTION, SOLUTION 300 mg INTRAMUSCULAR NDA 27 sections
Lincocin HUMAN PRESCRIPTION DRUG LABEL 1 0009-0555 INJECTION, SOLUTION 300 mg INTRAMUSCULAR NDA 27 sections
Lincocin HUMAN PRESCRIPTION DRUG LABEL 1 0009-0555 INJECTION, SOLUTION 300 mg INTRAMUSCULAR NDA 27 sections
Lincocin HUMAN PRESCRIPTION DRUG LABEL 1 0009-0555 INJECTION, SOLUTION 300 mg INTRAMUSCULAR NDA 27 sections
LINCOMYCIN HUMAN PRESCRIPTION DRUG LABEL 1 0404-9901 INJECTION, SOLUTION 300 mg INTRAMUSCULAR ANDA 14 sections
LINCOMYCIN HUMAN PRESCRIPTION DRUG LABEL 1 0404-9901 INJECTION, SOLUTION 300 mg INTRAMUSCULAR ANDA 14 sections
LINCOMYCIN HUMAN PRESCRIPTION DRUG LABEL 1 0404-9901 INJECTION, SOLUTION 300 mg INTRAMUSCULAR ANDA 14 sections
Lincomycin HUMAN PRESCRIPTION DRUG LABEL 1 25021-193 INJECTION, SOLUTION 300 mg INTRAVENOUS ANDA 28 sections
Lincomycin HUMAN PRESCRIPTION DRUG LABEL 1 39822-0350 INJECTION, SOLUTION 300 mg INTRAMUSCULAR ANDA 27 sections
Lincomycin HUMAN PRESCRIPTION DRUG LABEL 1 39822-0350 INJECTION, SOLUTION 300 mg INTRAMUSCULAR ANDA 27 sections
Lincomycin HUMAN PRESCRIPTION DRUG LABEL 1 39822-0353 INJECTION, SOLUTION 300 mg INTRAMUSCULAR ANDA 27 sections
Lincomycin HUMAN PRESCRIPTION DRUG LABEL 1 39822-0353 INJECTION, SOLUTION 300 mg INTRAMUSCULAR ANDA 27 sections
Lincomycin HUMAN PRESCRIPTION DRUG LABEL 1 42571-374 INJECTION, SOLUTION 300 mg INTRAVENOUS ANDA 22 sections
Lincomycin HUMAN PRESCRIPTION DRUG LABEL 1 42571-374 INJECTION, SOLUTION 300 mg INTRAVENOUS ANDA 22 sections
Lincomycin HUMAN PRESCRIPTION DRUG LABEL 1 50090-4533 INJECTION, SOLUTION 300 mg INTRAMUSCULAR ANDA 28 sections
Lincomycin HUMAN PRESCRIPTION DRUG LABEL 1 50090-4533 INJECTION, SOLUTION 300 mg INTRAMUSCULAR ANDA 28 sections
LINCOMYCIN HUMAN PRESCRIPTION DRUG LABEL 1 52584-353 INJECTION, SOLUTION 300 mg INTRAMUSCULAR ANDA 14 sections
lincomycin hydrochloride Human Prescription Drug Label 1 68083-478 INJECTION, SOLUTION 300 mg INTRAMUSCULAR ANDA 22 sections
Lincomycin hydrochloride Human Prescription Drug Label 1 68083-479 INJECTION, SOLUTION 300 mg INTRAMUSCULAR ANDA 22 sections
lincomycin HUMAN PRESCRIPTION DRUG LABEL 1 70436-034 INJECTION, SOLUTION 300 mg INTRAVENOUS ANDA 25 sections
lincomycin HUMAN PRESCRIPTION DRUG LABEL 1 70436-035 INJECTION, SOLUTION 300 mg INTRAVENOUS ANDA 25 sections
Lincomycin HUMAN PRESCRIPTION DRUG LABEL 1 70625-113 INJECTION, SOLUTION 300 mg INTRAMUSCULAR ANDA 27 sections