Stem definition | Drug id | CAS RN |
---|---|---|
antibiotics, produced by Streptomyces strains | 1582 | 154-21-2 |
Dose | Unit | Route |
---|---|---|
1.80 | g | O |
1.80 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 50 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 30 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 129.94 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 25 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 1 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 2.10 mL/min/kg | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 5.60 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 29, 1964 | FDA | PHARMACIA AND UPJOHN |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 239.31 | 65.54 | 68 | 120 | 310619 | 63178215 |
None
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 162.16 | 49.64 | 48 | 139 | 298868 | 79445333 |
None
Source | Code | Description |
---|---|---|
ATC | J01FF02 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS Lincosamides |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D011500 | Protein Synthesis Inhibitors |
CHEBI has role | CHEBI:33281 | antibiotics |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Pneumococcal infectious disease | indication | 16814004 | |
Staphylococcal infectious disease | indication | 56038003 | |
Streptococcal infectious disease | indication | 85769006 | |
Disorder of digestive system | contraindication | 53619000 | DOID:77 |
Acute nephropathy | contraindication | 58574008 | |
Hepatic failure | contraindication | 59927004 | |
Colitis | contraindication | 64226004 | DOID:0060180 |
Pseudomembranous enterocolitis | contraindication | 397683000 |
Species | Use | Relation |
---|---|---|
Bees | Control of American foulbrood (Paenibacillus larvae) | Indication |
Cats | Infections caused by gram-positive organisms (streptococci and staphylococci) | Indication |
Chickens | Control of airsacculitis caused by Mycoplasma synoviae | Indication |
Chickens | Control of airsacculitis caused by Mycoplasma gallisepticum | Indication |
Chickens | Complicated chronic respiratory disease (air sac infection) | Indication |
Chickens | Necrotic enteritis caused or complicated by Clostridium spp | Indication |
Dogs | Infections caused by gram-positive organisms (streptococci and staphylococci) | Indication |
Swine | Dysentery (bloody scours) | Indication |
Swine | Infectious arthritis | Indication |
Swine | Mycoplasma pneumonia | Indication |
Swine | Proliferative enteropathies (ileitis) caused by Lawsonia intracellularis | Indication |
Product | Applicant | Ingredients |
---|---|---|
Lincocin Tablets | Zoetis Inc. | 1 |
Lincocin, Lincomix 25 Injectable, Lincomix 50 Injectable, Lincomix 100 Injectable, Lincomix 300 Injectable | Zoetis Inc. | 1 |
Lincocin Aquadrops | Zoetis Inc. | 1 |
L-S 50 Water Soluble Powder | Zoetis Inc. | 2 |
LINCOMIX 20, LINCOMIX 50 | Zoetis Inc. | 1 |
LINCOMIX Soluble Powder | Zoetis Inc. | 1 |
LINCOMIX and Banminth | Phibro Animal Health Corp. | 2 |
LINCOMIX and Banminth | Zoetis Inc. | 2 |
SAFE-GUARD plus LINCOMIX | Intervet Inc. | 2 |
Stenorol and LINCOMIX | Huvepharma EOOD | 2 |
Robenz and LINCOMIX | Zoetis Inc. | 2 |
Deccox and LINCOMIX | Zoetis Inc. | 2 |
Bio-Cox and LINCOMIX | Zoetis Inc. | 2 |
COYDEN and LINCOMIX | Zoetis Inc. | 2 |
Avatec and LINCOMIX | Zoetis Inc. | 2 |
Zoamix and LINCOMIX | Zoetis Inc. | 2 |
Coban and LINCOMIX | Zoetis Inc. | 2 |
Lincomycin Soluble | Huvepharma EOOD | 1 |
Linco Soluble | Zoetis Inc. | 1 |
Lincosol Soluble Powder | Med-Pharmex Inc. | 1 |
Lincomycin Injectable 30% | Zoetis Inc. | 1 |
Lincomycin Hydrochloride Soluble Powder | Quo Vademus LLC | 1 |
Lincomycin 100, Lincomycin 25, Lincomycin 300, Lincomycin Injection 100, Lincomycin Injection 25, Lincomycin Injection 300 | Sparhawk Laboratories Inc. | 1 |
Lincomycin - Spectinomycin | Phibro Animal Health Corp. | 2 |
Lincomycin Injectable, USP | Huvepharma EOOD | 1 |
LincoMed 100, LincoMed 300 | Bimeda Animal Health Limited | 1 |
LinxMed-SP | Bimeda Animal Health Limited | 1 |
SpecLinx-50 | Bimeda Animal Health Limited | 2 |
Lincomycin-Spectinomycin Water Soluble Powder | Huvepharma EOOD | 2 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 12.37 | acidic |
pKa2 | 13.98 | acidic |
pKa3 | 8.22 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
50S ribosomal protein L10 | Ribosomal protein | WOMBAT-PK |
ID | Source |
---|---|
4019802 | VUID |
N0000147891 | NUI |
D00223 | KEGG_DRUG |
4018090 | VANDF |
4019802 | VANDF |
C0023726 | UMLSCUI |
CHEBI:6472 | CHEBI |
3QB | PDB_CHEM_ID |
CHEMBL1447 | ChEMBL_ID |
D008034 | MESH_DESCRIPTOR_UI |
DB01627 | DRUGBANK_ID |
3000540 | PUBCHEM_CID |
10941 | IUPHAR_LIGAND_ID |
1419 | INN_ID |
7179-49-9 | SECONDARY_CAS_RN |
BOD072YW0F | UNII |
6398 | RXNORM |
1950 | MMSL |
4979 | MMSL |
4980 | MMSL |
7112 | MMSL |
d00279 | MMSL |
002793 | NDDF |
004867 | NDDF |
18449009 | SNOMEDCT_US |
2596005 | SNOMEDCT_US |
372677003 | SNOMEDCT_US |
CHEMBL3989551 | ChEMBL_ID |
CHEMBL1201097 | ChEMBL_ID |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Lincocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0104 | INJECTION, SOLUTION | 300 mg | INTRAMUSCULAR | NDA | 27 sections |
Lincocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0104 | INJECTION, SOLUTION | 300 mg | INTRAMUSCULAR | NDA | 27 sections |
Lincocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0104 | INJECTION, SOLUTION | 300 mg | INTRAMUSCULAR | NDA | 27 sections |
Lincocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0104 | INJECTION, SOLUTION | 300 mg | INTRAMUSCULAR | NDA | 27 sections |
Lincocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0107 | INJECTION, SOLUTION | 300 mg | INTRAMUSCULAR | NDA | 27 sections |
Lincocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0107 | INJECTION, SOLUTION | 300 mg | INTRAMUSCULAR | NDA | 27 sections |
Lincocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0107 | INJECTION, SOLUTION | 300 mg | INTRAMUSCULAR | NDA | 27 sections |
Lincocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0107 | INJECTION, SOLUTION | 300 mg | INTRAMUSCULAR | NDA | 27 sections |
Lincocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0555 | INJECTION, SOLUTION | 300 mg | INTRAMUSCULAR | NDA | 27 sections |
Lincocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0555 | INJECTION, SOLUTION | 300 mg | INTRAMUSCULAR | NDA | 27 sections |
Lincocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0555 | INJECTION, SOLUTION | 300 mg | INTRAMUSCULAR | NDA | 27 sections |
Lincocin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0555 | INJECTION, SOLUTION | 300 mg | INTRAMUSCULAR | NDA | 27 sections |
LINCOMYCIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9901 | INJECTION, SOLUTION | 300 mg | INTRAMUSCULAR | ANDA | 14 sections |
LINCOMYCIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9901 | INJECTION, SOLUTION | 300 mg | INTRAMUSCULAR | ANDA | 14 sections |
LINCOMYCIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9901 | INJECTION, SOLUTION | 300 mg | INTRAMUSCULAR | ANDA | 14 sections |
Lincomycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-193 | INJECTION, SOLUTION | 300 mg | INTRAVENOUS | ANDA | 28 sections |
Lincomycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 39822-0350 | INJECTION, SOLUTION | 300 mg | INTRAMUSCULAR | ANDA | 27 sections |
Lincomycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 39822-0350 | INJECTION, SOLUTION | 300 mg | INTRAMUSCULAR | ANDA | 27 sections |
Lincomycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 39822-0353 | INJECTION, SOLUTION | 300 mg | INTRAMUSCULAR | ANDA | 27 sections |
Lincomycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 39822-0353 | INJECTION, SOLUTION | 300 mg | INTRAMUSCULAR | ANDA | 27 sections |
Lincomycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42571-374 | INJECTION, SOLUTION | 300 mg | INTRAVENOUS | ANDA | 22 sections |
Lincomycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42571-374 | INJECTION, SOLUTION | 300 mg | INTRAVENOUS | ANDA | 22 sections |
Lincomycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-4533 | INJECTION, SOLUTION | 300 mg | INTRAMUSCULAR | ANDA | 28 sections |
Lincomycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-4533 | INJECTION, SOLUTION | 300 mg | INTRAMUSCULAR | ANDA | 28 sections |
LINCOMYCIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52584-353 | INJECTION, SOLUTION | 300 mg | INTRAMUSCULAR | ANDA | 14 sections |
lincomycin hydrochloride | Human Prescription Drug Label | 1 | 68083-478 | INJECTION, SOLUTION | 300 mg | INTRAMUSCULAR | ANDA | 22 sections |
Lincomycin hydrochloride | Human Prescription Drug Label | 1 | 68083-479 | INJECTION, SOLUTION | 300 mg | INTRAMUSCULAR | ANDA | 22 sections |
lincomycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70436-034 | INJECTION, SOLUTION | 300 mg | INTRAVENOUS | ANDA | 25 sections |
lincomycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70436-035 | INJECTION, SOLUTION | 300 mg | INTRAVENOUS | ANDA | 25 sections |
Lincomycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70625-113 | INJECTION, SOLUTION | 300 mg | INTRAMUSCULAR | ANDA | 27 sections |