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limaprost 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| prostaglandins | 1581 | 74397-12-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Limaprost exerts potent effects on vasodilation, increase of blood flow and inhibition of platelet aggregation, and thereby has proven clinical effects on various ischemic symptoms such as ulcer, pain and feeling of coldness associated with thromboangiitis obliterans.
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,AURKA,AXL,BRAF,BTK,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,IKBKB,ITK,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CG,PIM2,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,TTK,ZAP70 | 45 | |||
| kinase-selectivity-class | AXL,EIF2AK3,GRK2,MAP2K6 | 4 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | PMDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Cardiac failure | 64.16 | 31.86 | 33 | 1503 | 109463 | 90517448 |
| Osteonecrosis of jaw | 55.87 | 31.86 | 22 | 1514 | 39081 | 90587830 |
| Interstitial lung disease | 53.49 | 31.86 | 26 | 1510 | 76379 | 90550532 |
| Renal impairment | 35.16 | 31.86 | 22 | 1514 | 105399 | 90521512 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Interstitial lung disease | 60.29 | 25.26 | 37 | 1547 | 78425 | 42541326 |
| Decreased appetite | 43.39 | 25.26 | 44 | 1540 | 193093 | 42426658 |
| Inappropriate antidiuretic hormone secretion | 40.14 | 25.26 | 17 | 1567 | 16524 | 42603227 |
| Cerebral infarction | 32.63 | 25.26 | 18 | 1566 | 31151 | 42588600 |
| Hepatic function abnormal | 26.59 | 25.26 | 19 | 1565 | 51548 | 42568203 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Interstitial lung disease | 110.19 | 25.51 | 63 | 3393 | 139271 | 110446572 |
| Cardiac failure | 72.09 | 25.51 | 54 | 3402 | 187572 | 110398271 |
| Hepatic function abnormal | 53.94 | 25.51 | 34 | 3422 | 89261 | 110496582 |
| Renal impairment | 52.62 | 25.51 | 45 | 3411 | 188400 | 110397443 |
| Cerebral infarction | 47.87 | 25.51 | 26 | 3430 | 51812 | 110534031 |
| Inappropriate antidiuretic hormone secretion | 42.87 | 25.51 | 21 | 3435 | 33830 | 110552013 |
| Decreased appetite | 41.72 | 25.51 | 62 | 3394 | 475784 | 110110059 |
| Osteonecrosis of jaw | 41.35 | 25.51 | 23 | 3433 | 47994 | 110537849 |
| Platelet count decreased | 39.44 | 25.51 | 42 | 3414 | 230401 | 110355442 |
| Altered state of consciousness | 32.44 | 25.51 | 21 | 3435 | 57605 | 110528238 |
| Colitis microscopic | 32.11 | 25.51 | 13 | 3443 | 13381 | 110572462 |
| Spinal compression fracture | 31.30 | 25.51 | 14 | 3442 | 18378 | 110567465 |
| Haemorrhage subcutaneous | 26.74 | 25.51 | 9 | 3447 | 5530 | 110580313 |
| Pneumonia | 26.24 | 25.51 | 73 | 3383 | 876641 | 109709202 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | B01AC28 | BLOOD AND BLOOD FORMING ORGANS ANTITHROMBOTIC AGENTS ANTITHROMBOTIC AGENTS Platelet aggregation inhibitors excl. heparin |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D014665 | Vasodilator Agents |
| CHEBI has role | CHEBI:50249 | anticoagulant |
Related Drugs by ATC class:
B01AC Platelet aggregation inhibitors excl. heparin 24 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Thromboangiitis obliterans | indication | 52403007 | DOID:12918 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.42 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Prostaglandin E2 receptor EP1 subtype | GPCR | AGONIST | KEGG DRUG | KEGG DRUG |
External reference:
| ID | Source |
|---|---|
| D02722 | KEGG_DRUG |
| C0064987 | UMLSCUI |
| CHEBI:135594 | CHEBI |
| CHEMBL2107456 | ChEMBL_ID |
| DB09211 | DRUGBANK_ID |
| C059238 | MESH_SUPPLEMENTAL_RECORD_UI |
| 6438378 | PUBCHEM_CID |
| C525749 | MESH_SUPPLEMENTAL_RECORD_UI |
| C025090 | MESH_SUPPLEMENTAL_RECORD_UI |
| 5899 | INN_ID |
| L02U804092 | UNII |
Pharmaceutical products:
None