limaprost Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prostaglandins 1581 74397-12-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • opalmon
  • limaprost alfadex
  • ONO1206
  • ONO 1206
  • limaprost
Limaprost exerts potent effects on vasodilation, increase of blood flow and inhibition of platelet aggregation, and thereby has proven clinical effects on various ischemic symptoms such as ulcer, pain and feeling of coldness associated with thromboangiitis obliterans.
  • Molecular weight: 380.53
  • Formula: C22H36O5
  • CLOGP: 3.44
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 94.83
  • ALOGS: -4.19
  • ROTB: 13

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None PMDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Interstitial lung disease 45.33 28.39 27 1712 53922 46630401
Hepatic function abnormal 39.11 28.39 21 1718 34400 46649923
Cardiac failure 35.67 28.39 27 1712 79921 46604402
Altered state of consciousness 28.64 28.39 15 1724 23333 46660990

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Interstitial lung disease 65.53 27.32 41 1623 60156 29890658
Cerebral infarction 41.94 27.32 23 1641 26350 29924464
Inappropriate antidiuretic hormone secretion 30.00 27.32 14 1650 11408 29939406

Pharmacologic Action:

SourceCodeDescription
MeSH PA D002317 Cardiovascular Agents
MeSH PA D014665 Vasodilator Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Thromboangiitis obliterans indication 52403007 DOID:12918

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.42 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin E2 receptor EP1 subtype GPCR AGONIST KEGG DRUG KEGG DRUG

External reference:

IDSource
D02722 KEGG_DRUG
C0064987 UMLSCUI
CHEMBL2107456 ChEMBL_ID
DB09211 DRUGBANK_ID
C059238 MESH_SUPPLEMENTAL_RECORD_UI
C025090 MESH_SUPPLEMENTAL_RECORD_UI
C525749 MESH_SUPPLEMENTAL_RECORD_UI
5899 INN_ID
L02U804092 UNII
6438378 PUBCHEM_CID

Pharmaceutical products:

None