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lidoflazine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1580 | 3416-26-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Coronary vasodilator with some antiarrhythmic action.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.18 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 40 % |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK2,JAK3,MAP3K7,MAPK10,MAPK7,MAPKAPK2,MET,NTRK2,PDK2,PDK4,PIK3CB,PIM2,PRKDC,SIK2,SIK3,STK33,TEK,TGFBR1 | 35 | |||
| kinase-selectivity-class | AXL,BRAF,DDR1,ERBB2,GRK2,PDK4,SIK2 | 7 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C08EX01 | CARDIOVASCULAR SYSTEM CALCIUM CHANNEL BLOCKERS NON-SELECTIVE CALCIUM CHANNEL BLOCKERS Other non-selective calcium channel blockers |
| MeSH PA | D000077264 | Calcium-Regulating Hormones and Agents |
| MeSH PA | D002121 | Calcium Channel Blockers |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D014665 | Vasodilator Agents |
| MeSH PA | D049990 | Membrane Transport Modulators |
Related Drugs by ATC class:
C08EX Other non-selective calcium channel blockers 1 drug
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 13.4 | acidic |
| pKa2 | 7.42 | Basic |
| pKa3 | 3.42 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 7.80 | CHEMBL | |||||
| Equilibrative nucleoside transporter 1 | Transporter | Ki | 6.55 | CHEMBL | |||||
| Sodium channel alpha subunits; brain (Types I, II, III) | Ion channel | Ki | 7.11 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N0000167118 | NUI |
| D04733 | KEGG_DRUG |
| C0023665 | UMLSCUI |
| CHEBI:93095 | CHEBI |
| CHEMBL92870 | ChEMBL_ID |
| D008013 | MESH_DESCRIPTOR_UI |
| DB13766 | DRUGBANK_ID |
| 1925 | INN_ID |
| J4ZHN3HBTE | UNII |
| 3926 | PUBCHEM_CID |
| 6390 | RXNORM |
| 319206000 | SNOMEDCT_US |
| 418865004 | SNOMEDCT_US |
| J4ZHN3HBTE | INXIGHT DRUGS |
Pharmaceutical products:
None