lidoflazine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1580 3416-26-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • lidoflazine
  • corflazine
  • lidoflazin
  • lidoflazinum
  • ordiflazine
Coronary vasodilator with some antiarrhythmic action.
  • Molecular weight: 491.63
  • Formula: C30H35F2N3O
  • CLOGP: 4.79
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 35.58
  • ALOGS: -5.74
  • ROTB: 9

Drug dosage:

DoseUnitRoute
0.18 g O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC C08EX01 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
NON-SELECTIVE CALCIUM CHANNEL BLOCKERS
Other non-selective calcium channel blockers
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D014665 Vasodilator Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.4 acidic
pKa2 7.42 Basic
pKa3 3.42 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Equilibrative nucleoside transporter 1 Transporter Ki 6.55 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 7.80 CHEMBL
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel Ki 7.11 CHEMBL

External reference:

IDSource
N0000167118 NUI
D04733 KEGG_DRUG
C0023665 UMLSCUI
CHEBI:93095 CHEBI
CHEMBL92870 ChEMBL_ID
D008013 MESH_DESCRIPTOR_UI
DB13766 DRUGBANK_ID
3926 PUBCHEM_CID
1925 INN_ID
J4ZHN3HBTE UNII
6390 RXNORM
319206000 SNOMEDCT_US
418865004 SNOMEDCT_US

Pharmaceutical products:

None