levonorgestrel 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| steroids, progestogens | 1572 | 797-63-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A synthetic progestational hormone with actions similar to those of PROGESTERONE and about twice as potent as its racemic or (+-)-isomer (NORGESTREL). It is used for contraception, control of menstrual disorders, and treatment of endometriosis.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 1.50 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Bocci G, Oprea TI, Benet LZ |
| S (Water solubility) | 0.01 mg/mL | Bocci G, Oprea TI, Benet LZ |
| EoM (Fraction excreted unchanged in urine) | 52 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.03 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 94 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 1.50 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 1.80 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.03 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 9.40 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| April 16, 1968 | FDA | WYETH PHARMS | |
| July 2, 2018 | PMDA | Nobelpharma Co., Ltd. |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Device expulsion | 125769.89 | 23.99 | 26185 | 131179 | 8737 | 63322921 |
| Device dislocation | 39315.79 | 23.99 | 9681 | 147683 | 16024 | 63315634 |
| Genital haemorrhage | 20358.42 | 23.99 | 4495 | 152869 | 2837 | 63328821 |
| Uterine perforation | 15528.32 | 23.99 | 3571 | 153793 | 3392 | 63328266 |
| Pregnancy with contraceptive device | 14071.41 | 23.99 | 3067 | 154297 | 1627 | 63330031 |
| Complication of device insertion | 11135.57 | 23.99 | 2775 | 154589 | 4789 | 63326869 |
| Procedural pain | 10699.66 | 23.99 | 3374 | 153990 | 18195 | 63313463 |
| Abdominal pain lower | 9735.51 | 23.99 | 3277 | 154087 | 22401 | 63309257 |
| Embedded device | 7798.69 | 23.99 | 1794 | 155570 | 1689 | 63329969 |
| Pelvic pain | 6911.75 | 23.99 | 2166 | 155198 | 11353 | 63320305 |
| Vaginal haemorrhage | 6420.42 | 23.99 | 2452 | 154912 | 25035 | 63306623 |
| Complication associated with device | 6127.56 | 23.99 | 2090 | 155274 | 14888 | 63316770 |
| Device difficult to use | 5604.68 | 23.99 | 1823 | 155541 | 10973 | 63320685 |
| Device breakage | 5183.38 | 23.99 | 1676 | 155688 | 9866 | 63321792 |
| Ectopic pregnancy with contraceptive device | 4840.26 | 23.99 | 1010 | 156354 | 241 | 63331417 |
| Complication of device removal | 4790.80 | 23.99 | 1313 | 156051 | 3829 | 63327829 |
| Device use issue | 4219.73 | 23.99 | 1035 | 156329 | 1595 | 63330063 |
| Heavy menstrual bleeding | 3945.44 | 23.99 | 1529 | 155835 | 16244 | 63315414 |
| Medical device discomfort | 3769.53 | 23.99 | 891 | 156473 | 1048 | 63330610 |
| Uterine rupture | 3635.17 | 23.99 | 778 | 156586 | 308 | 63331350 |
| Post procedural discomfort | 3463.46 | 23.99 | 751 | 156613 | 363 | 63331295 |
| Device issue | 3394.58 | 23.99 | 1492 | 155872 | 22289 | 63309369 |
| Medical device pain | 3149.62 | 23.99 | 741 | 156623 | 839 | 63330819 |
| Amenorrhoea | 2973.32 | 23.99 | 1064 | 156300 | 8850 | 63322808 |
| Injury | 2528.35 | 23.99 | 1804 | 155560 | 71443 | 63260215 |
| Dyspareunia | 2431.10 | 23.99 | 658 | 156706 | 1797 | 63329861 |
| Expired device used | 1958.89 | 23.99 | 412 | 156952 | 117 | 63331541 |
| Post procedural haemorrhage | 1916.11 | 23.99 | 727 | 156637 | 7237 | 63324421 |
| Emotional distress | 1902.53 | 23.99 | 1117 | 156247 | 31432 | 63300226 |
| Uterine spasm | 1610.26 | 23.99 | 367 | 156997 | 314 | 63331344 |
| Unintentional medical device removal | 1590.27 | 23.99 | 591 | 156773 | 5524 | 63326134 |
| Abdominal pain | 1550.76 | 23.99 | 2677 | 154687 | 290779 | 63040879 |
| Device deployment issue | 1522.73 | 23.99 | 510 | 156854 | 3392 | 63328266 |
| Loss of libido | 1441.34 | 23.99 | 384 | 156980 | 965 | 63330693 |
| Intermenstrual bleeding | 1397.28 | 23.99 | 578 | 156786 | 7348 | 63324310 |
| Ovarian cyst | 1253.03 | 23.99 | 665 | 156699 | 15280 | 63316378 |
| Diarrhoea | 1187.19 | 23.99 | 181 | 157183 | 715185 | 62616473 |
| Ruptured ectopic pregnancy | 1182.05 | 23.99 | 267 | 157097 | 209 | 63331449 |
| Procedural haemorrhage | 1175.85 | 23.99 | 383 | 156981 | 2305 | 63329353 |
| Haemorrhage in pregnancy | 1171.42 | 23.99 | 353 | 157011 | 1572 | 63330086 |
| Menstruation irregular | 1091.74 | 23.99 | 468 | 156896 | 6536 | 63325122 |
| Off label use of device | 1076.46 | 23.99 | 230 | 157134 | 88 | 63331570 |
| Dysmenorrhoea | 1033.05 | 23.99 | 384 | 156980 | 3589 | 63328069 |
| Uterine cervix stenosis | 1021.08 | 23.99 | 214 | 157150 | 56 | 63331602 |
| Device physical property issue | 1008.66 | 23.99 | 318 | 157046 | 1694 | 63329964 |
| Intentional device misuse | 983.13 | 23.99 | 255 | 157109 | 553 | 63331105 |
| Vaginal discharge | 978.71 | 23.99 | 471 | 156893 | 8727 | 63322931 |
| Pneumonia | 939.36 | 23.99 | 47 | 157317 | 456720 | 62874938 |
| Uterine haemorrhage | 900.64 | 23.99 | 349 | 157015 | 3692 | 63327966 |
| Coital bleeding | 891.89 | 23.99 | 217 | 157147 | 315 | 63331343 |
| Dyspnoea | 879.17 | 23.99 | 275 | 157089 | 661038 | 62670620 |
| Death | 826.24 | 23.99 | 22 | 157342 | 374359 | 62957299 |
| Pelvic inflammatory disease | 805.46 | 23.99 | 256 | 157108 | 1406 | 63330252 |
| Ectopic pregnancy | 793.80 | 23.99 | 282 | 157082 | 2285 | 63329373 |
| Depression | 770.29 | 23.99 | 1580 | 155784 | 194912 | 63136746 |
| Contraindicated device used | 760.46 | 23.99 | 152 | 157212 | 0 | 63331658 |
| Medical device monitoring error | 755.46 | 23.99 | 151 | 157213 | 0 | 63331658 |
| Fall | 707.84 | 23.99 | 75 | 157289 | 392259 | 62939399 |
| Uterine leiomyoma | 703.90 | 23.99 | 377 | 156987 | 8821 | 63322837 |
| Internal injury | 682.78 | 23.99 | 161 | 157203 | 185 | 63331473 |
| Anxiety | 681.98 | 23.99 | 1599 | 155765 | 215942 | 63115716 |
| Acne | 679.16 | 23.99 | 519 | 156845 | 22774 | 63308884 |
| Drug intolerance | 636.38 | 23.99 | 31 | 157333 | 308630 | 63023028 |
| Hypomenorrhoea | 630.91 | 23.99 | 167 | 157197 | 405 | 63331253 |
| Joint swelling | 627.43 | 23.99 | 49 | 157315 | 327617 | 63004041 |
| Drug hypersensitivity | 598.95 | 23.99 | 45 | 157319 | 310642 | 63021016 |
| Condition aggravated | 586.43 | 23.99 | 139 | 157225 | 402078 | 62929580 |
| Idiopathic intracranial hypertension | 582.47 | 23.99 | 233 | 157131 | 2698 | 63328960 |
| Acute kidney injury | 571.55 | 23.99 | 18 | 157346 | 263397 | 63068261 |
| Toxicity to various agents | 562.84 | 23.99 | 10 | 157354 | 247240 | 63084418 |
| Infusion related reaction | 550.57 | 23.99 | 12 | 157352 | 245509 | 63086149 |
| Rash | 549.90 | 23.99 | 358 | 157006 | 560513 | 62771145 |
| Libido decreased | 543.47 | 23.99 | 216 | 157148 | 2456 | 63329202 |
| Arthropathy | 516.80 | 23.99 | 14 | 157350 | 234778 | 63096880 |
| Rheumatoid arthritis | 508.97 | 23.99 | 30 | 157334 | 253789 | 63077869 |
| Abortion spontaneous | 506.90 | 23.99 | 605 | 156759 | 46590 | 63285068 |
| Fatigue | 498.03 | 23.99 | 904 | 156460 | 887124 | 62444534 |
| Breast tenderness | 495.56 | 23.99 | 195 | 157169 | 2155 | 63329503 |
| Infertility female | 493.81 | 23.99 | 137 | 157227 | 422 | 63331236 |
| Arthralgia | 483.52 | 23.99 | 422 | 156942 | 569288 | 62762370 |
| Breast cancer female | 476.11 | 23.99 | 338 | 157026 | 13221 | 63318437 |
| Uterine pain | 469.04 | 23.99 | 116 | 157248 | 188 | 63331470 |
| Nasopharyngitis | 467.52 | 23.99 | 45 | 157319 | 254212 | 63077446 |
| Menstrual disorder | 464.20 | 23.99 | 238 | 157126 | 5075 | 63326583 |
| Intra-uterine contraceptive device removal | 464.00 | 23.99 | 95 | 157269 | 12 | 63331646 |
| Cough | 453.24 | 23.99 | 88 | 157276 | 292655 | 63039003 |
| Contraindicated product administered | 447.93 | 23.99 | 22 | 157342 | 217626 | 63114032 |
| Device placement issue | 444.07 | 23.99 | 155 | 157209 | 1185 | 63330473 |
| Device use error | 443.23 | 23.99 | 237 | 157127 | 5524 | 63326134 |
| Pemphigus | 437.97 | 23.99 | 3 | 157361 | 183723 | 63147935 |
| Therapeutic product effect decreased | 434.77 | 23.99 | 9 | 157355 | 193178 | 63138480 |
| Swelling | 434.36 | 23.99 | 79 | 157285 | 275299 | 63056359 |
| Cervical dysplasia | 430.26 | 23.99 | 193 | 157171 | 3021 | 63328637 |
| Confusional state | 428.91 | 23.99 | 44 | 157320 | 236336 | 63095322 |
| Vomiting | 428.80 | 23.99 | 454 | 156910 | 559163 | 62772495 |
| Systemic lupus erythematosus | 427.12 | 23.99 | 22 | 157342 | 208896 | 63122762 |
| Mood swings | 426.10 | 23.99 | 357 | 157007 | 17891 | 63313767 |
| Hypotension | 423.98 | 23.99 | 81 | 157283 | 272523 | 63059135 |
| Menometrorrhagia | 423.67 | 23.99 | 139 | 157225 | 858 | 63330800 |
| Treatment failure | 416.47 | 23.99 | 18 | 157346 | 199025 | 63132633 |
| Peripheral swelling | 415.77 | 23.99 | 78 | 157286 | 265864 | 63065794 |
| Product dose omission issue | 414.00 | 23.99 | 48 | 157316 | 234265 | 63097393 |
| Menstruation delayed | 401.94 | 23.99 | 154 | 157210 | 1575 | 63330083 |
| Pyrexia | 394.62 | 23.99 | 352 | 157012 | 470126 | 62861532 |
| Hypersensitivity | 392.51 | 23.99 | 119 | 157245 | 292566 | 63039092 |
| Breast pain | 391.58 | 23.99 | 254 | 157110 | 8544 | 63323114 |
| Haemoperitoneum | 387.47 | 23.99 | 171 | 157193 | 2570 | 63329088 |
| Off label use | 386.84 | 23.99 | 676 | 156688 | 673786 | 62657872 |
| Device defective | 386.51 | 23.99 | 155 | 157209 | 1807 | 63329851 |
| Neutropenia | 382.92 | 23.99 | 11 | 157353 | 174994 | 63156664 |
| Sinusitis | 382.13 | 23.99 | 54 | 157310 | 226599 | 63105059 |
| Anaemia | 379.81 | 23.99 | 127 | 157237 | 293303 | 63038355 |
| Wound | 369.77 | 23.99 | 7 | 157357 | 163256 | 63168402 |
| Hepatic enzyme increased | 363.57 | 23.99 | 39 | 157325 | 202289 | 63129369 |
| Nausea | 355.06 | 23.99 | 1022 | 156342 | 853449 | 62478209 |
| Decreased appetite | 340.31 | 23.99 | 100 | 157264 | 250952 | 63080706 |
| Hypertension | 323.13 | 23.99 | 144 | 157220 | 279159 | 63052499 |
| Stomatitis | 322.40 | 23.99 | 4 | 157360 | 138721 | 63192937 |
| Dehydration | 320.33 | 23.99 | 30 | 157334 | 173324 | 63158334 |
| Malaise | 316.45 | 23.99 | 339 | 157025 | 415615 | 62916043 |
| Abdominal discomfort | 309.47 | 23.99 | 208 | 157156 | 320677 | 63010981 |
| Musculoskeletal stiffness | 308.77 | 23.99 | 45 | 157319 | 184573 | 63147085 |
| Pericarditis | 304.86 | 23.99 | 4 | 157360 | 131575 | 63200083 |
| Completed suicide | 301.95 | 23.99 | 14 | 157350 | 145659 | 63185999 |
| Asthenia | 294.69 | 23.99 | 310 | 157054 | 383294 | 62948364 |
| Lower respiratory tract infection | 290.56 | 23.99 | 8 | 157356 | 132299 | 63199359 |
| Drug interaction | 289.77 | 23.99 | 103 | 157261 | 229028 | 63102630 |
| Pain in extremity | 286.12 | 23.99 | 241 | 157123 | 331245 | 63000413 |
| Scar | 285.90 | 23.99 | 252 | 157112 | 13530 | 63318128 |
| Pruritus | 281.10 | 23.99 | 289 | 157075 | 361164 | 62970494 |
| Vaginal odour | 279.14 | 23.99 | 87 | 157277 | 443 | 63331215 |
| Febrile neutropenia | 277.11 | 23.99 | 3 | 157361 | 118446 | 63213212 |
| Thrombocytopenia | 277.03 | 23.99 | 27 | 157337 | 151130 | 63180528 |
| Abnormal uterine bleeding | 276.65 | 23.99 | 114 | 157250 | 1432 | 63330226 |
| Somnolence | 275.74 | 23.99 | 54 | 157310 | 178631 | 63153027 |
| Maternal exposure during pregnancy | 274.74 | 23.99 | 101 | 157263 | 219961 | 63111697 |
| White blood cell count decreased | 273.98 | 23.99 | 18 | 157346 | 139086 | 63192572 |
| Disease progression | 260.39 | 23.99 | 10 | 157354 | 122748 | 63208910 |
| Therapeutic product effect incomplete | 256.02 | 23.99 | 13 | 157351 | 125043 | 63206615 |
| Constipation | 255.37 | 23.99 | 119 | 157245 | 224824 | 63106834 |
| Device failure | 253.98 | 23.99 | 168 | 157196 | 5843 | 63325815 |
| Fear | 249.49 | 23.99 | 248 | 157116 | 15518 | 63316140 |
| Intra-abdominal haemorrhage | 249.25 | 23.99 | 122 | 157242 | 2347 | 63329311 |
| Weight decreased | 249.07 | 23.99 | 193 | 157171 | 276605 | 63055053 |
| Contusion | 245.31 | 23.99 | 39 | 157325 | 150005 | 63181653 |
| Erythema | 243.62 | 23.99 | 67 | 157297 | 175684 | 63155974 |
| Atrial fibrillation | 242.38 | 23.99 | 11 | 157353 | 116625 | 63215033 |
| Renal failure | 241.58 | 23.99 | 12 | 157352 | 117640 | 63214018 |
| Gait disturbance | 240.85 | 23.99 | 77 | 157287 | 183101 | 63148557 |
| Chlamydial infection | 238.54 | 23.99 | 71 | 157293 | 300 | 63331358 |
| Impaired healing | 238.04 | 23.99 | 3 | 157361 | 102539 | 63229119 |
| Hyponatraemia | 237.73 | 23.99 | 9 | 157355 | 111891 | 63219767 |
| Product use issue | 237.73 | 23.99 | 125 | 157239 | 220395 | 63111263 |
| Neuropathy peripheral | 235.30 | 23.99 | 11 | 157353 | 113656 | 63218002 |
| Meningioma | 233.79 | 23.99 | 136 | 157228 | 3749 | 63327909 |
| Injection site pain | 233.13 | 23.99 | 25 | 157339 | 129775 | 63201883 |
| Intentional product use issue | 231.33 | 23.99 | 24 | 157340 | 127868 | 63203790 |
| Pelvic discomfort | 230.39 | 23.99 | 80 | 157284 | 601 | 63331057 |
| Depressed mood | 228.62 | 23.99 | 380 | 156984 | 39811 | 63291847 |
| Blister | 228.13 | 23.99 | 27 | 157337 | 129787 | 63201871 |
| Intentional medical device removal by patient | 226.78 | 23.99 | 55 | 157309 | 78 | 63331580 |
| Anhedonia | 226.31 | 23.99 | 200 | 157164 | 10774 | 63320884 |
| Pancytopenia | 224.29 | 23.99 | 3 | 157361 | 96930 | 63234728 |
| Overdose | 223.37 | 23.99 | 16 | 157348 | 115062 | 63216596 |
| Adnexa uteri pain | 221.81 | 23.99 | 70 | 157294 | 374 | 63331284 |
| Polymenorrhoea | 221.77 | 23.99 | 91 | 157273 | 1130 | 63330528 |
| Bacterial vulvovaginitis | 218.19 | 23.99 | 80 | 157284 | 716 | 63330942 |
| Premenstrual syndrome | 214.78 | 23.99 | 77 | 157287 | 642 | 63331016 |
| Bronchitis | 212.24 | 23.99 | 29 | 157335 | 124906 | 63206752 |
| Platelet count decreased | 212.07 | 23.99 | 21 | 157343 | 116101 | 63215557 |
| Abortion of ectopic pregnancy | 211.95 | 23.99 | 44 | 157320 | 9 | 63331649 |
| Cardiac failure congestive | 209.07 | 23.99 | 4 | 157360 | 92429 | 63239229 |
| Uterine scar | 208.95 | 23.99 | 46 | 157318 | 27 | 63331631 |
| Hypokalaemia | 208.70 | 23.99 | 12 | 157352 | 103792 | 63227866 |
| Arthritis | 206.47 | 23.99 | 23 | 157341 | 115898 | 63215760 |
| Wheezing | 202.00 | 23.99 | 8 | 157356 | 95587 | 63236071 |
| Salpingitis | 201.58 | 23.99 | 59 | 157305 | 232 | 63331426 |
| Suppressed lactation | 200.80 | 23.99 | 66 | 157298 | 410 | 63331248 |
| Mood altered | 199.12 | 23.99 | 213 | 157151 | 14530 | 63317128 |
| Endometritis | 199.06 | 23.99 | 80 | 157284 | 938 | 63330720 |
| Presyncope | 197.39 | 23.99 | 291 | 157073 | 27494 | 63304164 |
| Mobility decreased | 196.88 | 23.99 | 32 | 157332 | 121127 | 63210531 |
| Respiratory failure | 195.30 | 23.99 | 15 | 157349 | 101843 | 63229815 |
| Osteoarthritis | 194.85 | 23.99 | 10 | 157354 | 95333 | 63236325 |
| Oxygen saturation decreased | 192.11 | 23.99 | 6 | 157358 | 88579 | 63243079 |
| Vaginal infection | 192.05 | 23.99 | 155 | 157209 | 7363 | 63324295 |
| Oedema peripheral | 191.89 | 23.99 | 116 | 157248 | 189395 | 63142263 |
| Progesterone receptor assay positive | 191.78 | 23.99 | 60 | 157304 | 310 | 63331348 |
| Chest pain | 189.88 | 23.99 | 154 | 157210 | 215805 | 63115853 |
| Pleural effusion | 189.79 | 23.99 | 10 | 157354 | 93200 | 63238458 |
| Malignant neoplasm progression | 188.02 | 23.99 | 3 | 157361 | 82118 | 63249540 |
| Blood pressure increased | 186.56 | 23.99 | 84 | 157280 | 161978 | 63169680 |
| Asthma | 185.64 | 23.99 | 44 | 157320 | 127517 | 63204141 |
| Smear cervix abnormal | 184.91 | 23.99 | 106 | 157258 | 2840 | 63328818 |
| Cardiac failure | 183.28 | 23.99 | 9 | 157355 | 89133 | 63242525 |
| Ill-defined disorder | 183.06 | 23.99 | 4 | 157360 | 81751 | 63249907 |
| Retained products of conception | 181.85 | 23.99 | 46 | 157318 | 86 | 63331572 |
| Blood creatinine increased | 180.20 | 23.99 | 9 | 157355 | 87835 | 63243823 |
| Psoriatic arthropathy | 179.72 | 23.99 | 12 | 157352 | 91508 | 63240150 |
| Haemoglobin decreased | 179.43 | 23.99 | 68 | 157296 | 145417 | 63186241 |
| Salpingectomy | 178.16 | 23.99 | 52 | 157312 | 202 | 63331456 |
| Pain | 177.10 | 23.99 | 2693 | 154671 | 737935 | 62593723 |
| Cardiac arrest | 176.38 | 23.99 | 14 | 157350 | 92531 | 63239127 |
| Sepsis | 175.26 | 23.99 | 80 | 157284 | 153043 | 63178615 |
| Blood cholesterol increased | 174.36 | 23.99 | 16 | 157348 | 94016 | 63237642 |
| Influenza | 173.80 | 23.99 | 30 | 157334 | 108692 | 63222966 |
| Endometriosis | 171.62 | 23.99 | 126 | 157238 | 5194 | 63326464 |
| Product use in unapproved indication | 171.21 | 23.99 | 117 | 157247 | 178963 | 63152695 |
| Hypertrichosis | 169.61 | 23.99 | 74 | 157290 | 1080 | 63330578 |
| Uterine cervical pain | 169.03 | 23.99 | 36 | 157328 | 13 | 63331645 |
| Loop electrosurgical excision procedure | 168.06 | 23.99 | 38 | 157326 | 30 | 63331628 |
| Device malfunction | 167.59 | 23.99 | 214 | 157150 | 17643 | 63314015 |
| Gastrointestinal disorder | 167.51 | 23.99 | 58 | 157306 | 131181 | 63200477 |
| Urinary tract infection | 167.32 | 23.99 | 248 | 157116 | 264436 | 63067222 |
| Renal impairment | 166.63 | 23.99 | 14 | 157350 | 88341 | 63243317 |
| Procedural dizziness | 166.47 | 23.99 | 43 | 157321 | 91 | 63331567 |
| Tubo-ovarian abscess | 161.96 | 23.99 | 53 | 157311 | 324 | 63331334 |
| Bacterial vaginosis | 159.92 | 23.99 | 76 | 157288 | 1366 | 63330292 |
| Actinomyces test positive | 159.84 | 23.99 | 34 | 157330 | 12 | 63331646 |
| Product shape issue | 157.77 | 23.99 | 39 | 157325 | 63 | 63331595 |
| Intentional overdose | 157.36 | 23.99 | 6 | 157358 | 74146 | 63257512 |
| Vulvovaginal pain | 157.35 | 23.99 | 93 | 157271 | 2642 | 63329016 |
| Ovarian cyst ruptured | 157.31 | 23.99 | 71 | 157293 | 1128 | 63330530 |
| Drug abuse | 156.93 | 23.99 | 5 | 157359 | 72513 | 63259145 |
| Herpes zoster | 155.69 | 23.99 | 13 | 157351 | 82449 | 63249209 |
| Device intolerance | 152.34 | 23.99 | 37 | 157327 | 53 | 63331605 |
| Irritability | 152.02 | 23.99 | 278 | 157086 | 31416 | 63300242 |
| Diffuse alopecia | 151.97 | 23.99 | 64 | 157300 | 852 | 63330806 |
| Uterine infection | 150.33 | 23.99 | 50 | 157314 | 324 | 63331334 |
| Haemorrhagic ovarian cyst | 149.76 | 23.99 | 59 | 157305 | 654 | 63331004 |
| COVID-19 | 149.58 | 23.99 | 47 | 157317 | 113056 | 63218602 |
| Oedema | 149.48 | 23.99 | 30 | 157334 | 97592 | 63234066 |
| Blood glucose increased | 148.17 | 23.99 | 17 | 157347 | 83739 | 63247919 |
| Irritable bowel syndrome | 147.63 | 23.99 | 16 | 157348 | 82396 | 63249262 |
| Oropharyngeal pain | 146.86 | 23.99 | 28 | 157336 | 94459 | 63237199 |
| Psychological trauma | 145.86 | 23.99 | 66 | 157298 | 1055 | 63330603 |
| Coma | 144.69 | 23.99 | 3 | 157361 | 64361 | 63267297 |
| Pelvic adhesions | 144.09 | 23.99 | 47 | 157317 | 284 | 63331374 |
| Cellulitis | 144.08 | 23.99 | 17 | 157347 | 81941 | 63249717 |
| Muscular weakness | 143.03 | 23.99 | 62 | 157302 | 122291 | 63209367 |
| Injection site erythema | 141.97 | 23.99 | 19 | 157345 | 83155 | 63248503 |
| Breast cancer | 141.77 | 23.99 | 347 | 157017 | 48036 | 63283622 |
| Folliculitis | 141.73 | 23.99 | 8 | 157356 | 70309 | 63261349 |
| Pelvic fluid collection | 141.32 | 23.99 | 60 | 157304 | 816 | 63330842 |
| C-reactive protein increased | 141.11 | 23.99 | 31 | 157333 | 94676 | 63236982 |
| Hydrometra | 140.84 | 23.99 | 33 | 157331 | 36 | 63331622 |
| Leukopenia | 138.46 | 23.99 | 15 | 157349 | 77275 | 63254383 |
| Therapy non-responder | 137.85 | 23.99 | 14 | 157350 | 75887 | 63255771 |
| Patient-device incompatibility | 137.34 | 23.99 | 39 | 157325 | 134 | 63331524 |
| Hospitalisation | 137.03 | 23.99 | 23 | 157341 | 85058 | 63246600 |
| Inappropriate schedule of product administration | 136.06 | 23.99 | 44 | 157320 | 103921 | 63227737 |
| Oestrogen receptor assay positive | 134.97 | 23.99 | 50 | 157314 | 462 | 63331196 |
| Interstitial lung disease | 134.93 | 23.99 | 4 | 157360 | 61904 | 63269754 |
| Dry mouth | 134.79 | 23.99 | 17 | 157347 | 77846 | 63253812 |
| Pelvic infection | 130.29 | 23.99 | 45 | 157319 | 332 | 63331326 |
| Migraine | 129.79 | 23.99 | 554 | 156810 | 102792 | 63228866 |
| Depressed level of consciousness | 128.47 | 23.99 | 6 | 157358 | 62072 | 63269586 |
| Dysphagia | 127.99 | 23.99 | 31 | 157333 | 88554 | 63243104 |
| Hypoxia | 126.32 | 23.99 | 5 | 157359 | 59787 | 63271871 |
| Medical device site discomfort | 125.52 | 23.99 | 41 | 157323 | 249 | 63331409 |
| Productive cough | 124.94 | 23.99 | 8 | 157356 | 63200 | 63268458 |
| Liver injury | 124.76 | 23.99 | 6 | 157358 | 60514 | 63271144 |
| Upper respiratory tract infection | 123.98 | 23.99 | 26 | 157338 | 82021 | 63249637 |
| Cardio-respiratory arrest | 123.42 | 23.99 | 6 | 157358 | 59953 | 63271705 |
| Hirsutism | 123.33 | 23.99 | 63 | 157301 | 1332 | 63330326 |
| Epistaxis | 123.20 | 23.99 | 17 | 157347 | 72708 | 63258950 |
| Vulvovaginal discomfort | 121.67 | 23.99 | 75 | 157289 | 2303 | 63329355 |
| Gynaecological chlamydia infection | 120.23 | 23.99 | 26 | 157338 | 12 | 63331646 |
| Panic attack | 120.15 | 23.99 | 206 | 157158 | 22125 | 63309533 |
| Procedural nausea | 119.87 | 23.99 | 53 | 157311 | 800 | 63330858 |
| Lung disorder | 119.81 | 23.99 | 9 | 157355 | 62252 | 63269406 |
| Pregnancy after post coital contraception | 119.70 | 23.99 | 25 | 157339 | 6 | 63331652 |
| Alanine aminotransferase increased | 119.05 | 23.99 | 54 | 157310 | 103716 | 63227942 |
| Osteoporosis | 117.19 | 23.99 | 6 | 157358 | 57332 | 63274326 |
| Hormone level abnormal | 116.20 | 23.99 | 74 | 157290 | 2409 | 63329249 |
| Uterine polyp | 116.09 | 23.99 | 69 | 157295 | 1981 | 63329677 |
| Neutrophil count decreased | 114.97 | 23.99 | 6 | 157358 | 56400 | 63275258 |
| Fibromyalgia | 114.52 | 23.99 | 29 | 157335 | 80391 | 63251267 |
| Gastrooesophageal reflux disease | 114.11 | 23.99 | 47 | 157317 | 95592 | 63236066 |
| Pregnancy with implant contraceptive | 113.38 | 23.99 | 75 | 157289 | 2608 | 63329050 |
| Type 2 diabetes mellitus | 112.88 | 23.99 | 13 | 157351 | 63855 | 63267803 |
| Haematosalpinx | 112.25 | 23.99 | 23 | 157341 | 3 | 63331655 |
| Aspartate aminotransferase increased | 111.60 | 23.99 | 42 | 157322 | 90235 | 63241423 |
| Myocardial infarction | 111.48 | 23.99 | 54 | 157310 | 99839 | 63231819 |
| Heart rate increased | 111.33 | 23.99 | 47 | 157317 | 94191 | 63237467 |
| Medical device entrapment | 110.06 | 23.99 | 22 | 157342 | 0 | 63331658 |
| Therapeutic response decreased | 110.05 | 23.99 | 12 | 157352 | 61513 | 63270145 |
| Nasal congestion | 109.70 | 23.99 | 16 | 157348 | 65644 | 63266014 |
| Rhinorrhoea | 109.51 | 23.99 | 16 | 157348 | 65561 | 63266097 |
| Bradycardia | 109.02 | 23.99 | 24 | 157340 | 73203 | 63258455 |
| Dyspepsia | 108.46 | 23.99 | 59 | 157305 | 102137 | 63229521 |
| Cataract | 107.68 | 23.99 | 9 | 157355 | 57044 | 63274614 |
| Uterine adhesions | 107.31 | 23.99 | 25 | 157339 | 26 | 63331632 |
| Hepatic adenoma | 107.25 | 23.99 | 38 | 157326 | 305 | 63331353 |
| Peritoneal adhesions | 107.23 | 23.99 | 35 | 157329 | 212 | 63331446 |
| Multiple organ dysfunction syndrome | 106.98 | 23.99 | 9 | 157355 | 56743 | 63274915 |
| Hyperkalaemia | 106.72 | 23.99 | 7 | 157357 | 54196 | 63277462 |
| Hypoglycaemia | 106.72 | 23.99 | 12 | 157352 | 60053 | 63271605 |
| Inflammation | 105.58 | 23.99 | 36 | 157328 | 82237 | 63249421 |
| Chest discomfort | 104.85 | 23.99 | 72 | 157292 | 109897 | 63221761 |
| Tremor | 103.40 | 23.99 | 105 | 157259 | 132134 | 63199524 |
| Abortion missed | 102.97 | 23.99 | 60 | 157304 | 1659 | 63329999 |
| Mucosal inflammation | 102.38 | 23.99 | 3 | 157361 | 46925 | 63284733 |
| Insomnia | 102.07 | 23.99 | 240 | 157124 | 215012 | 63116646 |
| Loss of personal independence in daily activities | 100.60 | 23.99 | 58 | 157306 | 97232 | 63234426 |
| Abdominal distension | 100.13 | 23.99 | 453 | 156911 | 86162 | 63245496 |
| Hallucination | 99.83 | 23.99 | 10 | 157354 | 54807 | 63276851 |
| Uterine injury | 98.97 | 23.99 | 24 | 157340 | 34 | 63331624 |
| Focal nodular hyperplasia | 98.44 | 23.99 | 41 | 157323 | 530 | 63331128 |
| Dizziness | 98.37 | 23.99 | 643 | 156721 | 429282 | 62902376 |
| Metabolic acidosis | 97.89 | 23.99 | 3 | 157361 | 45066 | 63286592 |
| Diabetes mellitus | 97.05 | 23.99 | 12 | 157352 | 55798 | 63275860 |
| Procedural vomiting | 97.02 | 23.99 | 40 | 157324 | 503 | 63331155 |
| Blood pressure systolic increased | 96.73 | 23.99 | 5 | 157359 | 47392 | 63284266 |
| Cervicitis | 96.16 | 23.99 | 39 | 157325 | 469 | 63331189 |
| Cervical polyp | 96.12 | 23.99 | 32 | 157332 | 208 | 63331450 |
| Chloasma | 95.88 | 23.99 | 22 | 157342 | 20 | 63331638 |
| Papilloedema | 95.59 | 23.99 | 79 | 157285 | 3881 | 63327777 |
| Dyspnoea exertional | 95.57 | 23.99 | 17 | 157347 | 60285 | 63271373 |
| Patient dissatisfaction with device | 95.05 | 23.99 | 19 | 157345 | 0 | 63331658 |
| Cervix injury | 95.05 | 23.99 | 19 | 157345 | 0 | 63331658 |
| Procedural complication | 94.37 | 23.99 | 90 | 157274 | 5349 | 63326309 |
| Uterine enlargement | 94.27 | 23.99 | 51 | 157313 | 1217 | 63330441 |
| Intentional product misuse | 92.66 | 23.99 | 19 | 157345 | 60898 | 63270760 |
| Pulmonary oedema | 92.54 | 23.99 | 13 | 157351 | 54860 | 63276798 |
| Device ineffective | 90.43 | 23.99 | 31 | 157333 | 223 | 63331435 |
| Musculoskeletal pain | 89.87 | 23.99 | 59 | 157305 | 92218 | 63239440 |
| Chronic kidney disease | 88.97 | 23.99 | 6 | 157358 | 45392 | 63286266 |
| Chlamydia test positive | 87.79 | 23.99 | 20 | 157344 | 17 | 63331641 |
| Injection site reaction | 87.49 | 23.99 | 19 | 157345 | 58505 | 63273153 |
| Intentional device use issue | 87.40 | 23.99 | 23 | 157341 | 54 | 63331604 |
| Genital discharge | 87.40 | 23.99 | 23 | 157341 | 54 | 63331604 |
| Endometrial hyperplasia | 87.38 | 23.99 | 43 | 157321 | 837 | 63330821 |
| Psoriasis | 86.87 | 23.99 | 54 | 157310 | 86903 | 63244755 |
| Genital pain | 86.66 | 23.99 | 35 | 157329 | 416 | 63331242 |
| Cervix disorder | 86.22 | 23.99 | 38 | 157326 | 569 | 63331089 |
| Salpingo-oophoritis | 86.04 | 23.99 | 26 | 157338 | 117 | 63331541 |
| Endometrial thickening | 85.99 | 23.99 | 33 | 157331 | 339 | 63331319 |
| Rhabdomyolysis | 85.58 | 23.99 | 6 | 157358 | 43945 | 63287713 |
| Chills | 85.29 | 23.99 | 93 | 157271 | 113285 | 63218373 |
| Gonorrhoea | 84.88 | 23.99 | 25 | 157339 | 101 | 63331557 |
| Hyperglycaemia | 83.64 | 23.99 | 5 | 157359 | 41862 | 63289796 |
| Actinomycosis | 83.03 | 23.99 | 44 | 157320 | 1006 | 63330652 |
| Uterine inflammation | 81.93 | 23.99 | 19 | 157345 | 19 | 63331639 |
| Gastrointestinal injury | 81.86 | 23.99 | 36 | 157328 | 536 | 63331122 |
| Uterine cervical laceration | 81.46 | 23.99 | 17 | 157347 | 4 | 63331654 |
| Joint stiffness | 80.70 | 23.99 | 6 | 157358 | 41863 | 63289795 |
| Skin ulcer | 80.66 | 23.99 | 7 | 157357 | 43038 | 63288620 |
| Procedural anxiety | 80.30 | 23.99 | 39 | 157325 | 737 | 63330921 |
| Colposcopy | 80.29 | 23.99 | 18 | 157346 | 13 | 63331645 |
| Red blood cell sedimentation rate increased | 80.15 | 23.99 | 8 | 157356 | 43974 | 63287684 |
| Incorrect dose administered | 79.12 | 23.99 | 25 | 157339 | 59943 | 63271715 |
| Septic shock | 79.06 | 23.99 | 33 | 157331 | 66596 | 63265062 |
| Encephalopathy | 79.05 | 23.99 | 4 | 157360 | 38616 | 63293042 |
| Wrong technique in product usage process | 78.74 | 23.99 | 28 | 157336 | 62312 | 63269346 |
| Flushing | 78.72 | 23.99 | 44 | 157320 | 75043 | 63256615 |
| Bursitis | 78.57 | 23.99 | 3 | 157361 | 37038 | 63294620 |
| Red blood cell count decreased | 77.85 | 23.99 | 6 | 157358 | 40639 | 63291019 |
| Injection site pruritus | 77.71 | 23.99 | 10 | 157354 | 45106 | 63286552 |
| Pregnancy test positive | 77.69 | 23.99 | 24 | 157340 | 118 | 63331540 |
| Adenomyosis | 77.45 | 23.99 | 34 | 157330 | 504 | 63331154 |
| Bone pain | 77.22 | 23.99 | 20 | 157344 | 54621 | 63277037 |
| Cardiac disorder | 76.98 | 23.99 | 16 | 157348 | 50800 | 63280858 |
| Agitation | 76.92 | 23.99 | 26 | 157338 | 59731 | 63271927 |
| Sedation | 76.43 | 23.99 | 5 | 157359 | 38804 | 63292854 |
| Injection site swelling | 76.28 | 23.99 | 13 | 157351 | 47559 | 63284099 |
| Uterine tenderness | 75.99 | 23.99 | 17 | 157347 | 12 | 63331646 |
| Anembryonic gestation | 75.85 | 23.99 | 34 | 157330 | 531 | 63331127 |
| Memory impairment | 75.71 | 23.99 | 88 | 157276 | 104170 | 63227488 |
| Injection site bruising | 75.40 | 23.99 | 8 | 157356 | 41902 | 63289756 |
| Post abortion haemorrhage | 75.37 | 23.99 | 21 | 157343 | 66 | 63331592 |
| Hepatic failure | 75.25 | 23.99 | 3 | 157361 | 35653 | 63296005 |
| Product contamination | 75.06 | 23.99 | 37 | 157327 | 723 | 63330935 |
| Abdominal pain upper | 74.51 | 23.99 | 262 | 157102 | 206182 | 63125476 |
| Dysphonia | 74.21 | 23.99 | 14 | 157350 | 47600 | 63284058 |
| Colitis | 74.09 | 23.99 | 15 | 157349 | 48513 | 63283145 |
| Pain in jaw | 74.06 | 23.99 | 10 | 157354 | 43486 | 63288172 |
| Myalgia | 73.81 | 23.99 | 158 | 157206 | 146371 | 63185287 |
| Diverticulitis | 72.60 | 23.99 | 7 | 157357 | 39550 | 63292108 |
| Acute respiratory failure | 72.45 | 23.99 | 3 | 157361 | 34482 | 63297176 |
| Adverse drug reaction | 72.31 | 23.99 | 55 | 157309 | 79659 | 63251999 |
| Respiratory tract infection | 71.93 | 23.99 | 9 | 157355 | 41474 | 63290184 |
| Benign hydatidiform mole | 71.92 | 23.99 | 22 | 157342 | 104 | 63331554 |
| Drug-induced liver injury | 71.54 | 23.99 | 8 | 157356 | 40214 | 63291444 |
| Liver disorder | 71.51 | 23.99 | 22 | 157342 | 53665 | 63277993 |
| Blood pressure fluctuation | 71.38 | 23.99 | 14 | 157350 | 46303 | 63285355 |
| Headache | 71.23 | 23.99 | 1123 | 156241 | 632118 | 62699540 |
| Respiratory distress | 71.17 | 23.99 | 3 | 157361 | 33948 | 63297710 |
| Pneumonitis | 70.99 | 23.99 | 4 | 157360 | 35218 | 63296440 |
| Balance disorder | 70.69 | 23.99 | 63 | 157301 | 84359 | 63247299 |
| Cognitive disorder | 70.61 | 23.99 | 25 | 157339 | 55790 | 63275868 |
| Human chorionic gonadotropin decreased | 70.36 | 23.99 | 18 | 157346 | 36 | 63331622 |
| Influenza like illness | 70.28 | 23.99 | 39 | 157325 | 66785 | 63264873 |
| Mental status changes | 70.12 | 23.99 | 8 | 157356 | 39591 | 63292067 |
| Penile pain | 70.04 | 23.99 | 14 | 157350 | 0 | 63331658 |
| Chemical poisoning | 69.87 | 23.99 | 19 | 157345 | 53 | 63331605 |
| Hepatotoxicity | 69.47 | 23.99 | 6 | 157358 | 37035 | 63294623 |
| Illness | 69.25 | 23.99 | 18 | 157346 | 49041 | 63282617 |
| Respiratory disorder | 68.94 | 23.99 | 8 | 157356 | 39074 | 63292584 |
| Multiple sclerosis relapse | 68.02 | 23.99 | 18 | 157346 | 48460 | 63283198 |
| Heart rate decreased | 67.68 | 23.99 | 15 | 157349 | 45545 | 63286113 |
| Orthostatic hypotension | 67.43 | 23.99 | 6 | 157358 | 36154 | 63295504 |
| Cervical conisation | 67.33 | 23.99 | 14 | 157350 | 3 | 63331655 |
| Hepatic function abnormal | 67.05 | 23.99 | 7 | 157357 | 37135 | 63294523 |
| Breast swelling | 66.04 | 23.99 | 42 | 157322 | 1364 | 63330294 |
| Lethargy | 66.03 | 23.99 | 28 | 157336 | 55979 | 63275679 |
| Haematochezia | 66.02 | 23.99 | 25 | 157339 | 53519 | 63278139 |
| Mouth ulceration | 65.70 | 23.99 | 4 | 157360 | 32980 | 63298678 |
| Rectal haemorrhage | 65.47 | 23.99 | 20 | 157344 | 49010 | 63282648 |
| Endometrial cancer | 64.95 | 23.99 | 58 | 157306 | 3167 | 63328491 |
| Lactic acidosis | 64.72 | 23.99 | 9 | 157355 | 38278 | 63293380 |
| Cerebrovascular accident | 64.54 | 23.99 | 105 | 157259 | 107919 | 63223739 |
| Pulmonary hypertension | 64.50 | 23.99 | 8 | 157356 | 37115 | 63294543 |
| Joint range of motion decreased | 64.39 | 23.99 | 4 | 157360 | 32424 | 63299234 |
| Blood potassium decreased | 64.14 | 23.99 | 13 | 157351 | 42013 | 63289645 |
| Acne cystic | 62.85 | 23.99 | 29 | 157335 | 486 | 63331172 |
| Full blood count abnormal | 62.72 | 23.99 | 4 | 157360 | 31713 | 63299945 |
| Hypocalcaemia | 62.71 | 23.99 | 4 | 157360 | 31709 | 63299949 |
| Vulvovaginal pruritus | 62.70 | 23.99 | 57 | 157307 | 3186 | 63328472 |
| Exposure during pregnancy | 62.64 | 23.99 | 188 | 157176 | 155359 | 63176299 |
| Localised infection | 62.24 | 23.99 | 3 | 157361 | 30207 | 63301451 |
| Uterine contractions abnormal | 61.94 | 23.99 | 23 | 157341 | 214 | 63331444 |
| Pericardial effusion | 61.88 | 23.99 | 3 | 157361 | 30055 | 63301603 |
| Therapy interrupted | 61.57 | 23.99 | 5 | 157359 | 32450 | 63299208 |
| No adverse event | 61.55 | 23.99 | 234 | 157130 | 41171 | 63290487 |
| Coronary artery disease | 61.39 | 23.99 | 5 | 157359 | 32372 | 63299286 |
| Hepatitis | 61.37 | 23.99 | 12 | 157352 | 39776 | 63291882 |
| Rash maculo-papular | 60.27 | 23.99 | 5 | 157359 | 31891 | 63299767 |
| Gastritis | 60.24 | 23.99 | 10 | 157354 | 37293 | 63294365 |
| Renal disorder | 60.08 | 23.99 | 6 | 157358 | 32968 | 63298690 |
| Habitual abortion | 60.03 | 23.99 | 12 | 157352 | 0 | 63331658 |
| Rash pruritic | 59.91 | 23.99 | 37 | 157327 | 59762 | 63271896 |
| Oligomenorrhoea | 59.87 | 23.99 | 33 | 157331 | 818 | 63330840 |
| Therapy cessation | 59.76 | 23.99 | 4 | 157360 | 30453 | 63301205 |
| Endometrial atrophy | 59.73 | 23.99 | 17 | 157347 | 59 | 63331599 |
| Unresponsive to stimuli | 59.46 | 23.99 | 7 | 157357 | 33809 | 63297849 |
| Medical device site pain | 59.11 | 23.99 | 21 | 157343 | 170 | 63331488 |
| Weight increased | 59.05 | 23.99 | 941 | 156423 | 259851 | 63071807 |
| Migraine with aura | 58.62 | 23.99 | 51 | 157313 | 2689 | 63328969 |
| Gait inability | 58.51 | 23.99 | 29 | 157335 | 52930 | 63278728 |
| Seborrhoea | 58.33 | 23.99 | 27 | 157337 | 456 | 63331202 |
| Cervix haemorrhage uterine | 58.08 | 23.99 | 14 | 157350 | 19 | 63331639 |
| Breast discharge | 57.17 | 23.99 | 34 | 157330 | 977 | 63330681 |
| Pancreatitis | 57.07 | 23.99 | 25 | 157339 | 49030 | 63282628 |
| Anaphylactic reaction | 56.95 | 23.99 | 48 | 157316 | 66052 | 63265606 |
| Skin exfoliation | 56.80 | 23.99 | 18 | 157346 | 43084 | 63288574 |
| Blood pressure decreased | 56.29 | 23.99 | 47 | 157317 | 64975 | 63266683 |
| Hypophagia | 56.15 | 23.99 | 6 | 157358 | 31253 | 63300405 |
| Treatment noncompliance | 56.03 | 23.99 | 12 | 157352 | 37313 | 63294345 |
| Ear infection | 55.92 | 23.99 | 13 | 157351 | 38200 | 63293458 |
| Sciatica | 55.88 | 23.99 | 9 | 157355 | 34315 | 63297343 |
| Clostridium difficile infection | 55.70 | 23.99 | 5 | 157359 | 29917 | 63301741 |
| Drug eruption | 55.62 | 23.99 | 4 | 157360 | 28690 | 63302968 |
| Genito-pelvic pain/penetration disorder | 55.18 | 23.99 | 12 | 157352 | 6 | 63331652 |
| Fallopian tube perforation | 55.03 | 23.99 | 11 | 157353 | 0 | 63331658 |
| Hypercalcaemia | 54.75 | 23.99 | 4 | 157360 | 28318 | 63303340 |
| Throat irritation | 54.71 | 23.99 | 13 | 157351 | 37634 | 63294024 |
| Liver function test abnormal | 53.81 | 23.99 | 26 | 157338 | 48155 | 63283503 |
| White blood cell count increased | 53.04 | 23.99 | 27 | 157337 | 48534 | 63283124 |
| Underdose | 52.73 | 23.99 | 4 | 157360 | 27452 | 63304206 |
| Incorrect route of product administration | 52.72 | 23.99 | 4 | 157360 | 27448 | 63304210 |
| Prescribed underdose | 52.56 | 23.99 | 6 | 157358 | 29683 | 63301975 |
| Endometrial hypertrophy | 52.10 | 23.99 | 22 | 157342 | 295 | 63331363 |
| Abdominal adhesions | 52.09 | 23.99 | 51 | 157313 | 3131 | 63328527 |
| Progesterone decreased | 52.08 | 23.99 | 17 | 157347 | 103 | 63331555 |
| Adnexa uteri cyst | 51.66 | 23.99 | 17 | 157347 | 106 | 63331552 |
| Uterine stenosis | 51.63 | 23.99 | 11 | 157353 | 4 | 63331654 |
| Ear pain | 51.46 | 23.99 | 13 | 157351 | 36105 | 63295553 |
| Blood alkaline phosphatase increased | 51.43 | 23.99 | 21 | 157343 | 42946 | 63288712 |
| Pregnancy on oral contraceptive | 51.27 | 23.99 | 32 | 157332 | 1005 | 63330653 |
| Intracranial pressure increased | 51.19 | 23.99 | 64 | 157300 | 5163 | 63326495 |
| Altered state of consciousness | 50.44 | 23.99 | 3 | 157361 | 25227 | 63306431 |
| Retained placenta or membranes | 50.30 | 23.99 | 22 | 157342 | 323 | 63331335 |
| Cervical discharge | 50.03 | 23.99 | 10 | 157354 | 0 | 63331658 |
| Biopsy endometrium | 50.03 | 23.99 | 10 | 157354 | 0 | 63331658 |
| Ectopic pregnancy under hormonal contraception | 50.03 | 23.99 | 10 | 157354 | 0 | 63331658 |
| Ulcer | 49.59 | 23.99 | 4 | 157360 | 26103 | 63305555 |
| Vulvovaginal mycotic infection | 49.56 | 23.99 | 65 | 157299 | 5501 | 63326157 |
| Cervical cyst | 49.27 | 23.99 | 17 | 157347 | 125 | 63331533 |
| Tooth disorder | 49.08 | 23.99 | 6 | 157358 | 28151 | 63303507 |
| Live birth | 48.48 | 23.99 | 4 | 157360 | 25626 | 63306032 |
| Macular degeneration | 48.42 | 23.99 | 3 | 157361 | 24373 | 63307285 |
| Infection | 48.21 | 23.99 | 351 | 157013 | 228822 | 63102836 |
| Dysgeusia | 48.06 | 23.99 | 28 | 157336 | 46682 | 63284976 |
| Swelling face | 47.80 | 23.99 | 52 | 157312 | 63423 | 63268235 |
| Disorientation | 47.68 | 23.99 | 19 | 157345 | 39433 | 63292225 |
| Cervix inflammation | 47.41 | 23.99 | 10 | 157354 | 3 | 63331655 |
| Haematemesis | 47.27 | 23.99 | 9 | 157355 | 30403 | 63301255 |
| Abortion spontaneous incomplete | 47.24 | 23.99 | 12 | 157352 | 23 | 63331635 |
| Uterine haematoma | 47.24 | 23.99 | 12 | 157352 | 23 | 63331635 |
| Oral pain | 47.23 | 23.99 | 7 | 157357 | 28387 | 63303271 |
| Road traffic accident | 47.04 | 23.99 | 16 | 157348 | 36616 | 63295042 |
| Drug withdrawal syndrome | 46.90 | 23.99 | 6 | 157358 | 27188 | 63304470 |
| Negative thoughts | 46.83 | 23.99 | 29 | 157335 | 898 | 63330760 |
| Viral infection | 46.81 | 23.99 | 15 | 157349 | 35648 | 63296010 |
| Cyst | 46.58 | 23.99 | 106 | 157258 | 13993 | 63317665 |
| Hepatic cirrhosis | 46.40 | 23.99 | 4 | 157360 | 24730 | 63306928 |
| Complication of pregnancy | 46.27 | 23.99 | 25 | 157339 | 595 | 63331063 |
| General physical health deterioration | 46.05 | 23.99 | 301 | 157063 | 201101 | 63130557 |
| Tachycardia | 46.00 | 23.99 | 145 | 157219 | 118011 | 63213647 |
| Cerebral haemorrhage | 45.88 | 23.99 | 10 | 157354 | 30719 | 63300939 |
| Expired product administered | 45.72 | 23.99 | 66 | 157298 | 6115 | 63325543 |
| Joint injury | 45.44 | 23.99 | 9 | 157355 | 29563 | 63302095 |
| Ovarian germ cell teratoma benign | 45.39 | 23.99 | 15 | 157349 | 95 | 63331563 |
| Blood sodium decreased | 45.28 | 23.99 | 4 | 157360 | 24248 | 63307410 |
| Blood creatine phosphokinase increased | 45.23 | 23.99 | 10 | 157354 | 30420 | 63301238 |
| Lower limb fracture | 45.21 | 23.99 | 4 | 157360 | 24217 | 63307441 |
| Breast discomfort | 45.21 | 23.99 | 23 | 157341 | 482 | 63331176 |
| Toxic epidermal necrolysis | 45.15 | 23.99 | 5 | 157359 | 25329 | 63306329 |
| Haematoma | 45.07 | 23.99 | 15 | 157349 | 34805 | 63296853 |
| Chlamydial pelvic inflammatory disease | 45.02 | 23.99 | 9 | 157355 | 0 | 63331658 |
| Biopsy cervix | 45.02 | 23.99 | 9 | 157355 | 0 | 63331658 |
| Uterine fibrosis | 45.02 | 23.99 | 9 | 157355 | 0 | 63331658 |
| Staphylococcal infection | 44.96 | 23.99 | 23 | 157341 | 41233 | 63290425 |
| Gastric ulcer | 44.78 | 23.99 | 4 | 157360 | 24033 | 63307625 |
| Vulvovaginal dryness | 44.72 | 23.99 | 45 | 157319 | 2856 | 63328802 |
| Oral candidiasis | 44.71 | 23.99 | 3 | 157361 | 22795 | 63308863 |
| Agranulocytosis | 44.70 | 23.99 | 5 | 157359 | 25129 | 63306529 |
| Liver function test increased | 44.51 | 23.99 | 13 | 157351 | 32798 | 63298860 |
| Pelvic haemorrhage | 44.46 | 23.99 | 16 | 157348 | 135 | 63331523 |
| Oral herpes | 44.38 | 23.99 | 6 | 157358 | 26068 | 63305590 |
| Fallopian tube disorder | 44.35 | 23.99 | 22 | 157342 | 436 | 63331222 |
| Haematocrit decreased | 44.28 | 23.99 | 21 | 157343 | 39319 | 63292339 |
| Leukocytosis | 44.06 | 23.99 | 6 | 157358 | 25929 | 63305729 |
| Fear of disease | 43.95 | 23.99 | 32 | 157332 | 1302 | 63330356 |
| Pelvic organ injury | 43.63 | 23.99 | 10 | 157354 | 9 | 63331649 |
| Acute abdomen | 43.54 | 23.99 | 34 | 157330 | 1539 | 63330119 |
| Osteonecrosis | 43.32 | 23.99 | 5 | 157359 | 24525 | 63307133 |
| Limb injury | 43.04 | 23.99 | 6 | 157358 | 25471 | 63306187 |
| Rash erythematous | 43.00 | 23.99 | 26 | 157338 | 42484 | 63289174 |
| Cervix carcinoma stage 0 | 42.93 | 23.99 | 20 | 157344 | 343 | 63331315 |
| Hepatocellular injury | 42.77 | 23.99 | 8 | 157356 | 27373 | 63304285 |
| Blood lactate dehydrogenase increased | 42.66 | 23.99 | 4 | 157360 | 23112 | 63308546 |
| Cystitis | 42.58 | 23.99 | 44 | 157320 | 54947 | 63276711 |
| Dry skin | 42.39 | 23.99 | 47 | 157317 | 56840 | 63274818 |
| Seizure | 42.23 | 23.99 | 177 | 157187 | 132457 | 63199201 |
| Skin lesion | 41.99 | 23.99 | 12 | 157352 | 30709 | 63300949 |
| Hypoaesthesia | 41.95 | 23.99 | 245 | 157119 | 168148 | 63163510 |
| Eosinophilia | 41.83 | 23.99 | 4 | 157360 | 22752 | 63308906 |
| Skin laceration | 41.72 | 23.99 | 4 | 157360 | 22704 | 63308954 |
| Sexually transmitted disease | 41.58 | 23.99 | 17 | 157347 | 209 | 63331449 |
| Pulmonary mass | 41.46 | 23.99 | 4 | 157360 | 22592 | 63309066 |
| Device allergy | 41.45 | 23.99 | 12 | 157352 | 45 | 63331613 |
| Acute myocardial infarction | 41.30 | 23.99 | 14 | 157350 | 32110 | 63299548 |
| Acute respiratory distress syndrome | 41.06 | 23.99 | 5 | 157359 | 23529 | 63308129 |
| Suicide attempt | 40.48 | 23.99 | 55 | 157309 | 60863 | 63270795 |
| Cytomegalovirus infection | 40.39 | 23.99 | 3 | 157361 | 20949 | 63310709 |
| Haemangioma of liver | 40.35 | 23.99 | 29 | 157335 | 1156 | 63330502 |
| Blood bilirubin increased | 40.04 | 23.99 | 21 | 157343 | 37119 | 63294539 |
| Chlamydial cervicitis | 40.02 | 23.99 | 8 | 157356 | 0 | 63331658 |
| Basal cell carcinoma | 40.02 | 23.99 | 10 | 157354 | 27981 | 63303677 |
| Frequent bowel movements | 39.90 | 23.99 | 5 | 157359 | 23017 | 63308641 |
| Hepatic steatosis | 39.76 | 23.99 | 11 | 157353 | 28758 | 63302900 |
| Transaminases increased | 39.76 | 23.99 | 14 | 157350 | 31353 | 63300305 |
| Ovarian vein thrombosis | 39.53 | 23.99 | 12 | 157352 | 55 | 63331603 |
| Abnormal withdrawal bleeding | 39.36 | 23.99 | 12 | 157352 | 56 | 63331602 |
| Papilloma viral infection | 39.32 | 23.99 | 32 | 157332 | 1538 | 63330120 |
| Bladder perforation | 39.18 | 23.99 | 15 | 157349 | 153 | 63331505 |
| Gastric disorder | 39.01 | 23.99 | 22 | 157342 | 37347 | 63294311 |
| Gastroenteritis | 39.00 | 23.99 | 9 | 157355 | 26581 | 63305077 |
| Rib fracture | 38.94 | 23.99 | 5 | 157359 | 22592 | 63309066 |
| Atelectasis | 38.90 | 23.99 | 4 | 157360 | 21479 | 63310179 |
| Affective disorder | 38.87 | 23.99 | 61 | 157303 | 6085 | 63325573 |
| Adnexal torsion | 38.68 | 23.99 | 20 | 157344 | 434 | 63331224 |
| Fluid retention | 38.55 | 23.99 | 55 | 157309 | 59631 | 63272027 |
| Infertility | 38.36 | 23.99 | 24 | 157340 | 757 | 63330901 |
| Genital infection bacterial | 37.48 | 23.99 | 8 | 157356 | 3 | 63331655 |
| Sleep apnoea syndrome | 36.93 | 23.99 | 13 | 157351 | 29120 | 63302538 |
| Urticaria | 36.78 | 23.99 | 250 | 157114 | 165552 | 63166106 |
| Neoplasm malignant | 36.71 | 23.99 | 14 | 157350 | 29847 | 63301811 |
| Pulmonary arterial hypertension | 36.57 | 23.99 | 6 | 157358 | 22571 | 63309087 |
| Breast cancer in situ | 36.22 | 23.99 | 30 | 157334 | 1478 | 63330180 |
| Loss of consciousness | 36.15 | 23.99 | 160 | 157204 | 117961 | 63213697 |
| Dyskinesia | 36.15 | 23.99 | 17 | 157347 | 31985 | 63299673 |
| Sinus tachycardia | 36.02 | 23.99 | 8 | 157356 | 24260 | 63307398 |
| Lymphocyte count decreased | 35.87 | 23.99 | 15 | 157349 | 30242 | 63301416 |
| Toxic shock syndrome streptococcal | 35.69 | 23.99 | 13 | 157351 | 114 | 63331544 |
| Stevens-Johnson syndrome | 35.50 | 23.99 | 9 | 157355 | 24941 | 63306717 |
| Ventricular tachycardia | 35.46 | 23.99 | 4 | 157360 | 19975 | 63311683 |
| Nodule | 35.40 | 23.99 | 5 | 157359 | 21021 | 63310637 |
| Fallopian tube cyst | 35.29 | 23.99 | 13 | 157351 | 118 | 63331540 |
| Obesity | 35.26 | 23.99 | 15 | 157349 | 29937 | 63301721 |
| Subchorionic haemorrhage | 35.23 | 23.99 | 14 | 157350 | 159 | 63331499 |
| Depression suicidal | 35.16 | 23.99 | 32 | 157332 | 1791 | 63329867 |
| Head injury | 35.12 | 23.99 | 12 | 157352 | 27384 | 63304274 |
| Pelvic abscess | 35.11 | 23.99 | 31 | 157333 | 1667 | 63329991 |
| Persistent urogenital sinus | 35.02 | 23.99 | 7 | 157357 | 0 | 63331658 |
| Conjunctivitis | 34.89 | 23.99 | 5 | 157359 | 20791 | 63310867 |
| Intervertebral disc protrusion | 34.82 | 23.99 | 8 | 157356 | 23701 | 63307957 |
| Dry eye | 34.62 | 23.99 | 30 | 157334 | 40731 | 63290927 |
| Cholestasis | 34.24 | 23.99 | 15 | 157349 | 29419 | 63302239 |
| Blood potassium increased | 34.24 | 23.99 | 3 | 157361 | 18306 | 63313352 |
| Spinal fracture | 34.15 | 23.99 | 3 | 157361 | 18268 | 63313390 |
| Uterine cyst | 34.11 | 23.99 | 18 | 157346 | 408 | 63331250 |
| Hydrosalpinx | 34.01 | 23.99 | 8 | 157356 | 9 | 63331649 |
| Alopecia | 33.76 | 23.99 | 611 | 156753 | 336925 | 62994733 |
| Drug ineffective | 33.61 | 23.99 | 3014 | 154350 | 1041751 | 62289907 |
| Intentional self-injury | 33.36 | 23.99 | 11 | 157353 | 25676 | 63305982 |
| Electrolyte imbalance | 33.28 | 23.99 | 5 | 157359 | 20071 | 63311587 |
| Dysarthria | 33.26 | 23.99 | 34 | 157330 | 42677 | 63288981 |
| Breast cyst | 33.25 | 23.99 | 31 | 157333 | 1790 | 63329868 |
| Exostosis | 33.20 | 23.99 | 3 | 157361 | 17859 | 63313799 |
| Paraesthesia | 33.19 | 23.99 | 240 | 157124 | 156726 | 63174932 |
| Haemorrhagic cyst | 33.13 | 23.99 | 14 | 157350 | 188 | 63331470 |
| Vertigo | 33.10 | 23.99 | 258 | 157106 | 59629 | 63272029 |
| Disease recurrence | 33.06 | 23.99 | 14 | 157350 | 28016 | 63303642 |
| Blood glucose decreased | 32.99 | 23.99 | 6 | 157358 | 20946 | 63310712 |
| Pancreatitis acute | 32.96 | 23.99 | 13 | 157351 | 27153 | 63304505 |
| Device deposit issue | 32.86 | 23.99 | 9 | 157355 | 26 | 63331632 |
| Joint dislocation | 32.78 | 23.99 | 4 | 157360 | 18796 | 63312862 |
| Metastases to liver | 32.74 | 23.99 | 9 | 157355 | 23630 | 63308028 |
| Blood pressure diastolic decreased | 32.68 | 23.99 | 8 | 157356 | 22698 | 63308960 |
| Drug dependence | 32.66 | 23.99 | 10 | 157354 | 24473 | 63307185 |
| Gilbert's syndrome | 32.53 | 23.99 | 7 | 157357 | 3 | 63331655 |
| Laboratory test abnormal | 32.45 | 23.99 | 13 | 157351 | 26899 | 63304759 |
| Movement disorder | 32.44 | 23.99 | 7 | 157357 | 21654 | 63310004 |
| Post abortion complication | 32.33 | 23.99 | 8 | 157356 | 13 | 63331645 |
| Haematuria | 32.15 | 23.99 | 16 | 157348 | 29141 | 63302517 |
| Wound infection | 31.89 | 23.99 | 7 | 157357 | 21403 | 63310255 |
| Bronchospasm | 31.86 | 23.99 | 3 | 157361 | 17277 | 63314381 |
| Acute hepatic failure | 31.71 | 23.99 | 4 | 157360 | 18323 | 63313335 |
| Placenta accreta | 31.62 | 23.99 | 14 | 157350 | 212 | 63331446 |
| Urinary retention | 31.40 | 23.99 | 18 | 157346 | 30283 | 63301375 |
| Toothache | 31.33 | 23.99 | 5 | 157359 | 19194 | 63312464 |
| Perineal pain | 31.20 | 23.99 | 15 | 157349 | 277 | 63331381 |
| Metastases to bone | 31.05 | 23.99 | 7 | 157357 | 21012 | 63310646 |
| Gastroenteritis viral | 31.05 | 23.99 | 10 | 157354 | 23690 | 63307968 |
| Hypothyroidism | 30.92 | 23.99 | 36 | 157328 | 42596 | 63289062 |
| Infusion site pain | 30.91 | 23.99 | 3 | 157361 | 16866 | 63314792 |
| Premature menopause | 30.89 | 23.99 | 22 | 157342 | 864 | 63330794 |
| Adrenal insufficiency | 30.78 | 23.99 | 4 | 157360 | 17911 | 63313747 |
| Glaucoma | 30.68 | 23.99 | 5 | 157359 | 18900 | 63312758 |
| Respiratory tract congestion | 30.59 | 23.99 | 4 | 157360 | 17828 | 63313830 |
| Genital infection female | 30.55 | 23.99 | 11 | 157353 | 93 | 63331565 |
| Uterine mass | 30.48 | 23.99 | 15 | 157349 | 292 | 63331366 |
| Injection site rash | 30.46 | 23.99 | 5 | 157359 | 18804 | 63312854 |
| Procedural headache | 30.22 | 23.99 | 12 | 157352 | 136 | 63331522 |
| Neutrophil count increased | 30.13 | 23.99 | 3 | 157361 | 16524 | 63315134 |
| Labelled drug-disease interaction medication error | 30.06 | 23.99 | 12 | 157352 | 138 | 63331520 |
| Otosclerosis | 30.02 | 23.99 | 6 | 157358 | 0 | 63331658 |
| Inadequate lubrication | 30.02 | 23.99 | 6 | 157358 | 0 | 63331658 |
| Fear of pregnancy | 30.02 | 23.99 | 6 | 157358 | 0 | 63331658 |
| Fallopian tube obstruction | 30.02 | 23.99 | 6 | 157358 | 0 | 63331658 |
| Eye pain | 29.88 | 23.99 | 24 | 157340 | 33830 | 63297828 |
| Haemoptysis | 29.86 | 23.99 | 17 | 157347 | 28709 | 63302949 |
| Vulvovaginal swelling | 29.78 | 23.99 | 18 | 157346 | 533 | 63331125 |
| Ectropion of cervix | 29.78 | 23.99 | 10 | 157354 | 67 | 63331591 |
| Pulmonary congestion | 29.66 | 23.99 | 4 | 157360 | 17414 | 63314244 |
| Burning sensation | 29.66 | 23.99 | 56 | 157308 | 54351 | 63277307 |
| Endometrial disorder | 29.64 | 23.99 | 20 | 157344 | 719 | 63330939 |
| Angina pectoris | 29.59 | 23.99 | 19 | 157345 | 30059 | 63301599 |
| Lymphopenia | 29.40 | 23.99 | 5 | 157359 | 18322 | 63313336 |
| Abnormal weight gain | 29.34 | 23.99 | 29 | 157335 | 1801 | 63329857 |
| Female genital operation | 29.24 | 23.99 | 8 | 157356 | 23 | 63331635 |
| Emotional disorder | 29.13 | 23.99 | 86 | 157278 | 13293 | 63318365 |
| Pregnancy | 28.89 | 23.99 | 173 | 157191 | 36663 | 63294995 |
| Menopausal symptoms | 28.81 | 23.99 | 33 | 157331 | 2428 | 63329230 |
| Laryngitis | 28.65 | 23.99 | 4 | 157360 | 16963 | 63314695 |
| Cyanosis | 28.58 | 23.99 | 4 | 157360 | 16931 | 63314727 |
| Skin discolouration | 28.46 | 23.99 | 31 | 157333 | 37797 | 63293861 |
| Osteopenia | 28.42 | 23.99 | 7 | 157357 | 19778 | 63311880 |
| Product administration error | 28.38 | 23.99 | 10 | 157354 | 22387 | 63309271 |
| Musculoskeletal disorder | 28.33 | 23.99 | 8 | 157356 | 20636 | 63311022 |
| Product prescribing error | 28.14 | 23.99 | 15 | 157349 | 26274 | 63305384 |
| Blood test abnormal | 28.07 | 23.99 | 3 | 157361 | 15626 | 63316032 |
| Mitral valve incompetence | 28.01 | 23.99 | 7 | 157357 | 19587 | 63312071 |
| Sinus disorder | 27.80 | 23.99 | 13 | 157351 | 24540 | 63307118 |
| Peripheral venous disease | 27.72 | 23.99 | 3 | 157361 | 15474 | 63316184 |
| Eye irritation | 27.52 | 23.99 | 10 | 157354 | 21961 | 63309697 |
| Ocular hyperaemia | 27.42 | 23.99 | 14 | 157350 | 25130 | 63306528 |
| Body temperature increased | 27.41 | 23.99 | 31 | 157333 | 37161 | 63294497 |
| Hallucination, visual | 27.39 | 23.99 | 7 | 157357 | 19291 | 63312367 |
| Small intestinal obstruction | 27.31 | 23.99 | 6 | 157358 | 18331 | 63313327 |
| Bacteraemia | 27.25 | 23.99 | 5 | 157359 | 17343 | 63314315 |
| Invasive ductal breast carcinoma | 27.21 | 23.99 | 56 | 157308 | 6902 | 63324756 |
| Uterine dilation and curettage | 27.17 | 23.99 | 21 | 157343 | 936 | 63330722 |
| Swollen tongue | 26.76 | 23.99 | 28 | 157336 | 34772 | 63296886 |
| Uterine disorder | 26.66 | 23.99 | 36 | 157328 | 3133 | 63328525 |
| Ovarian rupture | 26.65 | 23.99 | 8 | 157356 | 35 | 63331623 |
| Oesophagitis | 26.65 | 23.99 | 3 | 157361 | 15005 | 63316653 |
| Skin infection | 26.64 | 23.99 | 3 | 157361 | 14999 | 63316659 |
| Adnexa uteri mass | 26.62 | 23.99 | 17 | 157347 | 556 | 63331102 |
| Joint effusion | 26.61 | 23.99 | 5 | 157359 | 17055 | 63314603 |
| Human papilloma virus test positive | 26.57 | 23.99 | 17 | 157347 | 558 | 63331100 |
| Lacrimation increased | 26.51 | 23.99 | 9 | 157355 | 20622 | 63311036 |
| Retinal vein thrombosis | 26.47 | 23.99 | 16 | 157348 | 474 | 63331184 |
| Feeling hot | 26.43 | 23.99 | 53 | 157311 | 50301 | 63281357 |
| Ovarian abscess | 26.29 | 23.99 | 12 | 157352 | 196 | 63331462 |
| Ankle fracture | 26.27 | 23.99 | 6 | 157358 | 17849 | 63313809 |
| Injection site mass | 26.03 | 23.99 | 7 | 157357 | 18649 | 63313009 |
| Genital discomfort | 25.99 | 23.99 | 9 | 157355 | 67 | 63331591 |
| Platelet count increased | 25.96 | 23.99 | 6 | 157358 | 17705 | 63313953 |
| Intervertebral disc degeneration | 25.89 | 23.99 | 4 | 157360 | 15728 | 63315930 |
| Induced abortion haemorrhage | 25.87 | 23.99 | 6 | 157358 | 6 | 63331652 |
| Polyneuropathy | 25.70 | 23.99 | 3 | 157361 | 14586 | 63317072 |
| Retroplacental haematoma | 25.69 | 23.99 | 11 | 157353 | 153 | 63331505 |
| Neck pain | 25.63 | 23.99 | 87 | 157277 | 69231 | 63262427 |
| Hysteroscopy | 25.62 | 23.99 | 8 | 157356 | 41 | 63331617 |
| Female sexual dysfunction | 25.62 | 23.99 | 8 | 157356 | 41 | 63331617 |
| Hypoacusis | 25.53 | 23.99 | 14 | 157350 | 24137 | 63307521 |
| Pharyngitis | 25.51 | 23.99 | 9 | 157355 | 20134 | 63311524 |
| Abortion induced | 25.39 | 23.99 | 69 | 157295 | 10173 | 63321485 |
| Candida infection | 25.15 | 23.99 | 20 | 157344 | 28331 | 63303327 |
| Polycystic ovaries | 25.04 | 23.99 | 42 | 157322 | 4429 | 63327229 |
| Myometritis | 25.01 | 23.99 | 5 | 157359 | 0 | 63331658 |
| Cervical friability | 25.01 | 23.99 | 5 | 157359 | 0 | 63331658 |
| Cervix erythema | 25.01 | 23.99 | 5 | 157359 | 0 | 63331658 |
| Genital injury | 25.01 | 23.99 | 5 | 157359 | 0 | 63331658 |
| Ectopic pregnancy termination | 24.95 | 23.99 | 6 | 157358 | 8 | 63331650 |
| Weight loss poor | 24.89 | 23.99 | 22 | 157342 | 1185 | 63330473 |
| Angioedema | 24.74 | 23.99 | 51 | 157313 | 47914 | 63283744 |
| Polymenorrhagia | 24.71 | 23.99 | 8 | 157356 | 47 | 63331611 |
| Spinal osteoarthritis | 24.71 | 23.99 | 5 | 157359 | 16181 | 63315477 |
| Galactorrhoea | 24.58 | 23.99 | 40 | 157324 | 4115 | 63327543 |
| Diabetes mellitus inadequate control | 24.54 | 23.99 | 4 | 157360 | 15122 | 63316536 |
| Endometrial adenocarcinoma | 24.44 | 23.99 | 22 | 157342 | 1214 | 63330444 |
| Lactation disorder | 24.39 | 23.99 | 14 | 157350 | 376 | 63331282 |
| Lymphadenopathy | 24.28 | 23.99 | 36 | 157328 | 38422 | 63293236 |
| Jaundice | 24.27 | 23.99 | 22 | 157342 | 29229 | 63302429 |
| Hemianaesthesia | 24.22 | 23.99 | 14 | 157350 | 381 | 63331277 |
| Eye disorder | 24.20 | 23.99 | 13 | 157351 | 22672 | 63308986 |
| Cholelithiasis | 24.13 | 23.99 | 45 | 157319 | 43880 | 63287778 |
| Libido disorder | 24.03 | 23.99 | 8 | 157356 | 52 | 63331606 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Penile pain | 3082.64 | 714.68 | 342 | 186 | 1221 | 34955182 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Device expulsion | 95440.64 | 29.63 | 18307 | 104224 | 7554 | 79614303 |
| Device dislocation | 29197.68 | 29.63 | 6959 | 115572 | 19011 | 79602846 |
| Genital haemorrhage | 16657.42 | 29.63 | 3408 | 119123 | 2847 | 79619010 |
| Uterine perforation | 14334.57 | 29.63 | 3014 | 119517 | 3289 | 79618568 |
| Pregnancy with contraceptive device | 11135.13 | 29.63 | 2229 | 120302 | 1425 | 79620432 |
| Complication of device insertion | 9787.60 | 29.63 | 2207 | 120324 | 4143 | 79617714 |
| Procedural pain | 9556.38 | 29.63 | 2813 | 119718 | 20271 | 79601586 |
| Abdominal pain lower | 8131.06 | 29.63 | 2680 | 119851 | 29102 | 79592755 |
| Embedded device | 6586.78 | 29.63 | 1420 | 121111 | 1899 | 79619958 |
| Pelvic pain | 6140.16 | 29.63 | 1768 | 120763 | 11613 | 79610244 |
| Vaginal haemorrhage | 5428.28 | 29.63 | 1803 | 120728 | 20014 | 79601843 |
| Device difficult to use | 5028.46 | 29.63 | 1515 | 121016 | 11870 | 79609987 |
| Ectopic pregnancy with contraceptive device | 4541.10 | 29.63 | 864 | 121667 | 221 | 79621636 |
| Complication of device removal | 3925.77 | 29.63 | 960 | 121571 | 2929 | 79618928 |
| Device breakage | 3857.45 | 29.63 | 1173 | 121358 | 9502 | 79612355 |
| Heavy menstrual bleeding | 3660.11 | 29.63 | 1202 | 121329 | 12809 | 79609048 |
| Device issue | 3510.18 | 29.63 | 1383 | 121148 | 25725 | 79596132 |
| Device use issue | 3475.78 | 29.63 | 816 | 121715 | 1968 | 79619889 |
| Medical device discomfort | 3453.93 | 29.63 | 746 | 121785 | 1008 | 79620849 |
| Complication associated with device | 3235.38 | 29.63 | 1159 | 121372 | 16337 | 79605520 |
| Post procedural discomfort | 3234.61 | 29.63 | 646 | 121885 | 394 | 79621463 |
| Injury | 3180.91 | 29.63 | 1786 | 120745 | 75710 | 79546147 |
| Amenorrhoea | 2756.12 | 29.63 | 840 | 121691 | 6852 | 79615005 |
| Medical device pain | 2729.81 | 29.63 | 593 | 121938 | 838 | 79621019 |
| Uterine rupture | 2564.34 | 29.63 | 501 | 122030 | 220 | 79621637 |
| Dyspareunia | 2272.36 | 29.63 | 540 | 121991 | 1398 | 79620459 |
| Emotional distress | 2142.69 | 29.63 | 1101 | 121430 | 38868 | 79582989 |
| Device deployment issue | 1483.23 | 29.63 | 427 | 122104 | 2785 | 79619072 |
| Post procedural haemorrhage | 1440.62 | 29.63 | 603 | 121928 | 13141 | 79608716 |
| Uterine spasm | 1393.60 | 29.63 | 287 | 122244 | 250 | 79621607 |
| Unintentional medical device removal | 1380.23 | 29.63 | 499 | 122032 | 7213 | 79614644 |
| Ovarian cyst | 1328.99 | 29.63 | 556 | 121975 | 12099 | 79609758 |
| Abdominal pain | 1328.38 | 29.63 | 2242 | 120289 | 387327 | 79234530 |
| Haemorrhage in pregnancy | 1260.19 | 29.63 | 316 | 122215 | 1098 | 79620759 |
| Loss of libido | 1257.92 | 29.63 | 361 | 122170 | 2324 | 79619533 |
| Intermenstrual bleeding | 1198.05 | 29.63 | 419 | 122112 | 5465 | 79616392 |
| Ruptured ectopic pregnancy | 1151.61 | 29.63 | 236 | 122295 | 195 | 79621662 |
| Expired device used | 1109.64 | 29.63 | 227 | 122304 | 184 | 79621673 |
| Dysmenorrhoea | 1016.08 | 29.63 | 315 | 122216 | 2730 | 79619127 |
| Procedural haemorrhage | 1000.05 | 29.63 | 346 | 122185 | 4360 | 79617497 |
| Depression | 971.05 | 29.63 | 1416 | 121115 | 215374 | 79406483 |
| Intentional device misuse | 963.32 | 29.63 | 227 | 122304 | 558 | 79621299 |
| Menstruation irregular | 946.77 | 29.63 | 338 | 122193 | 4698 | 79617159 |
| Off label use of device | 945.93 | 29.63 | 197 | 122334 | 192 | 79621665 |
| Vaginal discharge | 920.43 | 29.63 | 368 | 122163 | 7095 | 79614762 |
| Uterine cervix stenosis | 915.18 | 29.63 | 175 | 122356 | 50 | 79621807 |
| Anxiety | 899.61 | 29.63 | 1471 | 121060 | 247041 | 79374816 |
| Diarrhoea | 885.62 | 29.63 | 147 | 122384 | 880342 | 78741515 |
| Pneumonia | 855.60 | 29.63 | 38 | 122493 | 660208 | 78961649 |
| Uterine haemorrhage | 838.49 | 29.63 | 269 | 122262 | 2634 | 79619223 |
| Device physical property issue | 822.83 | 29.63 | 259 | 122272 | 2371 | 79619486 |
| Coital bleeding | 791.00 | 29.63 | 167 | 122364 | 185 | 79621672 |
| Death | 777.98 | 29.63 | 20 | 122511 | 566494 | 79055363 |
| Pelvic inflammatory disease | 769.34 | 29.63 | 213 | 122318 | 1179 | 79620678 |
| Internal injury | 744.84 | 29.63 | 161 | 122370 | 218 | 79621639 |
| Abortion spontaneous | 741.60 | 29.63 | 498 | 122033 | 29009 | 79592848 |
| Acute kidney injury | 738.25 | 29.63 | 12 | 122519 | 519392 | 79102465 |
| Ectopic pregnancy | 695.80 | 29.63 | 207 | 122324 | 1536 | 79620321 |
| Medical device monitoring error | 685.03 | 29.63 | 125 | 122406 | 0 | 79621857 |
| Dyspnoea | 678.21 | 29.63 | 237 | 122294 | 856788 | 78765069 |
| Contraindicated device used | 668.59 | 29.63 | 122 | 122409 | 0 | 79621857 |
| Uterine leiomyoma | 652.68 | 29.63 | 276 | 122255 | 6167 | 79615690 |
| Hypomenorrhoea | 617.92 | 29.63 | 141 | 122390 | 283 | 79621574 |
| Toxicity to various agents | 601.90 | 29.63 | 9 | 122522 | 421531 | 79200326 |
| Fall | 547.39 | 29.63 | 57 | 122474 | 487572 | 79134285 |
| Pain | 511.79 | 29.63 | 2285 | 120246 | 701517 | 78920340 |
| Acne | 505.63 | 29.63 | 382 | 122149 | 26808 | 79595049 |
| Infertility female | 499.79 | 29.63 | 120 | 122411 | 329 | 79621528 |
| Hypotension | 456.16 | 29.63 | 67 | 122464 | 440250 | 79181607 |
| Condition aggravated | 449.69 | 29.63 | 109 | 122422 | 501015 | 79120842 |
| Menstrual disorder | 438 | 29.63 | 182 | 122349 | 3885 | 79617972 |
| Device use error | 425.07 | 29.63 | 211 | 122320 | 6890 | 79614967 |
| Breast pain | 420.33 | 29.63 | 220 | 122311 | 8045 | 79613812 |
| Breast tenderness | 417.90 | 29.63 | 150 | 122381 | 2118 | 79619739 |
| Menometrorrhagia | 410.94 | 29.63 | 113 | 122418 | 607 | 79621250 |
| Neutropenia | 402.75 | 29.63 | 8 | 122523 | 287702 | 79334155 |
| Drug interaction | 399.42 | 29.63 | 77 | 122454 | 415106 | 79206751 |
| Uterine pain | 398.95 | 29.63 | 85 | 122446 | 102 | 79621755 |
| Device placement issue | 390.65 | 29.63 | 122 | 122409 | 1085 | 79620772 |
| Libido decreased | 384.81 | 29.63 | 180 | 122351 | 5141 | 79616716 |
| Menstruation delayed | 382.74 | 29.63 | 125 | 122406 | 1301 | 79620556 |
| Cervical dysplasia | 379.74 | 29.63 | 138 | 122393 | 2023 | 79619834 |
| Pyrexia | 378.92 | 29.63 | 294 | 122237 | 678415 | 78943442 |
| Device defective | 372.74 | 29.63 | 132 | 122399 | 1788 | 79620069 |
| Anaemia | 372.32 | 29.63 | 111 | 122420 | 444904 | 79176953 |
| Breast cancer female | 366.00 | 29.63 | 225 | 122306 | 11236 | 79610621 |
| Haemoperitoneum | 355.10 | 29.63 | 160 | 122371 | 4183 | 79617674 |
| Confusional state | 354.40 | 29.63 | 38 | 122493 | 317959 | 79303898 |
| Mood swings | 346.98 | 29.63 | 269 | 122262 | 19611 | 79602246 |
| Off label use | 345.83 | 29.63 | 539 | 121992 | 906676 | 78715181 |
| Rash | 345.52 | 29.63 | 233 | 122298 | 578125 | 79043732 |
| Scar | 345.09 | 29.63 | 241 | 122290 | 14955 | 79606902 |
| Cough | 344.43 | 29.63 | 72 | 122459 | 366717 | 79255140 |
| Completed suicide | 339.36 | 29.63 | 8 | 122523 | 245759 | 79376098 |
| Drug hypersensitivity | 337.53 | 29.63 | 34 | 122497 | 298882 | 79322975 |
| Intra-uterine contraceptive device removal | 334.28 | 29.63 | 63 | 122468 | 12 | 79621845 |
| Thrombocytopenia | 324.91 | 29.63 | 21 | 122510 | 265238 | 79356619 |
| Joint swelling | 312.82 | 29.63 | 38 | 122493 | 288608 | 79333249 |
| Device failure | 310.82 | 29.63 | 164 | 122367 | 6097 | 79615760 |
| Infusion related reaction | 308.59 | 29.63 | 10 | 122521 | 230227 | 79391630 |
| Vomiting | 299.51 | 29.63 | 350 | 122181 | 665478 | 78956379 |
| Drug intolerance | 298.27 | 29.63 | 30 | 122501 | 264089 | 79357768 |
| Dehydration | 288.75 | 29.63 | 25 | 122506 | 248162 | 79373695 |
| Abnormal uterine bleeding | 283.72 | 29.63 | 93 | 122438 | 980 | 79620877 |
| Decreased appetite | 283.36 | 29.63 | 87 | 122444 | 342331 | 79279526 |
| Fear | 274.39 | 29.63 | 245 | 122286 | 21741 | 79600116 |
| Nasopharyngitis | 273.66 | 29.63 | 34 | 122497 | 253847 | 79368010 |
| Depressed mood | 271.00 | 29.63 | 353 | 122178 | 48127 | 79573730 |
| Renal failure | 268.35 | 29.63 | 9 | 122522 | 200959 | 79420898 |
| Atrial fibrillation | 260.27 | 29.63 | 10 | 122521 | 197876 | 79423981 |
| Product dose omission issue | 255.30 | 29.63 | 38 | 122493 | 247499 | 79374358 |
| Vaginal odour | 253.23 | 29.63 | 69 | 122462 | 356 | 79621501 |
| Idiopathic intracranial hypertension | 248.58 | 29.63 | 114 | 122417 | 3108 | 79618749 |
| Disease progression | 247.06 | 29.63 | 8 | 122523 | 184354 | 79437503 |
| Anhedonia | 239.34 | 29.63 | 192 | 122339 | 14706 | 79607151 |
| Pancytopenia | 238.61 | 29.63 | 3 | 122528 | 165742 | 79456115 |
| Migraine | 238.27 | 29.63 | 458 | 122073 | 87035 | 79534822 |
| Rheumatoid arthritis | 237.11 | 29.63 | 23 | 122508 | 208447 | 79413410 |
| Drug abuse | 233.96 | 29.63 | 3 | 122528 | 162688 | 79459169 |
| Hyponatraemia | 233.84 | 29.63 | 9 | 122522 | 177839 | 79444018 |
| Platelet count decreased | 233.69 | 29.63 | 17 | 122514 | 194647 | 79427210 |
| Arthropathy | 232.74 | 29.63 | 9 | 122522 | 177102 | 79444755 |
| Somnolence | 232.41 | 29.63 | 43 | 122488 | 238938 | 79382919 |
| Respiratory failure | 231.74 | 29.63 | 11 | 122520 | 180900 | 79440957 |
| Uterine scar | 231.51 | 29.63 | 46 | 122485 | 26 | 79621831 |
| Sepsis | 229.14 | 29.63 | 65 | 122466 | 269363 | 79352494 |
| Adnexa uteri pain | 228.15 | 29.63 | 61 | 122470 | 289 | 79621568 |
| White blood cell count decreased | 227.30 | 29.63 | 16 | 122515 | 188272 | 79433585 |
| Hypertension | 226.25 | 29.63 | 113 | 122418 | 330879 | 79290978 |
| Peripheral swelling | 225.71 | 29.63 | 67 | 122464 | 269550 | 79352307 |
| Pelvic discomfort | 225.39 | 29.63 | 68 | 122463 | 532 | 79621325 |
| Cardiac arrest | 225.28 | 29.63 | 9 | 122522 | 172087 | 79449770 |
| Asthenia | 224.48 | 29.63 | 274 | 122257 | 511415 | 79110442 |
| Overdose | 224.27 | 29.63 | 15 | 122516 | 184191 | 79437666 |
| Therapeutic product effect decreased | 223.61 | 29.63 | 6 | 122525 | 163857 | 79458000 |
| Arthralgia | 222.78 | 29.63 | 334 | 122197 | 571469 | 79050388 |
| Polymenorrhoea | 221.90 | 29.63 | 76 | 122455 | 926 | 79620931 |
| Intra-abdominal haemorrhage | 214.31 | 29.63 | 115 | 122416 | 4425 | 79617432 |
| Cardiac failure | 206.46 | 29.63 | 7 | 122524 | 154835 | 79467022 |
| Stomatitis | 205.57 | 29.63 | 4 | 122527 | 146753 | 79475104 |
| Blood creatinine increased | 203.32 | 29.63 | 8 | 122523 | 155049 | 79466808 |
| Meningioma | 203.25 | 29.63 | 109 | 122422 | 4189 | 79617668 |
| Salpingitis | 201.06 | 29.63 | 49 | 122482 | 146 | 79621711 |
| Abortion of ectopic pregnancy | 200.99 | 29.63 | 38 | 122493 | 8 | 79621849 |
| Progesterone receptor assay positive | 199.12 | 29.63 | 51 | 122480 | 197 | 79621660 |
| Cardiac failure congestive | 198.99 | 29.63 | 4 | 122527 | 142398 | 79479459 |
| Malaise | 197.73 | 29.63 | 279 | 122252 | 489590 | 79132267 |
| Renal impairment | 197.64 | 29.63 | 11 | 122520 | 157772 | 79464085 |
| Erythema | 197.15 | 29.63 | 50 | 122481 | 223240 | 79398617 |
| Salpingectomy | 196.77 | 29.63 | 49 | 122482 | 164 | 79621693 |
| Treatment failure | 196.00 | 29.63 | 18 | 122513 | 170468 | 79451389 |
| Endometritis | 193.53 | 29.63 | 65 | 122466 | 743 | 79621114 |
| Malignant neoplasm progression | 193.40 | 29.63 | 3 | 122528 | 135987 | 79485870 |
| Fatigue | 190.77 | 29.63 | 760 | 121771 | 928967 | 78692890 |
| Hypersensitivity | 189.23 | 29.63 | 83 | 122448 | 262156 | 79359701 |
| Contraindicated product administered | 188.38 | 29.63 | 14 | 122517 | 157524 | 79464333 |
| Weight decreased | 187.61 | 29.63 | 162 | 122369 | 355036 | 79266821 |
| Bacterial vulvovaginitis | 186.82 | 29.63 | 59 | 122472 | 546 | 79621311 |
| Premenstrual syndrome | 186.49 | 29.63 | 58 | 122473 | 508 | 79621349 |
| Haemoglobin decreased | 184.42 | 29.63 | 56 | 122475 | 222063 | 79399794 |
| Constipation | 184.01 | 29.63 | 103 | 122428 | 282947 | 79338910 |
| Hypokalaemia | 183.69 | 29.63 | 9 | 122522 | 144031 | 79477826 |
| Pleural effusion | 182.33 | 29.63 | 10 | 122521 | 145252 | 79476605 |
| Endometriosis | 181.85 | 29.63 | 96 | 122435 | 3572 | 79618285 |
| Neuropathy peripheral | 179.65 | 29.63 | 9 | 122522 | 141296 | 79480561 |
| Sinusitis | 178.02 | 29.63 | 41 | 122490 | 195460 | 79426397 |
| Procedural dizziness | 177.42 | 29.63 | 40 | 122491 | 74 | 79621783 |
| Hepatic enzyme increased | 177.21 | 29.63 | 33 | 122498 | 182577 | 79439280 |
| Lower respiratory tract infection | 175.30 | 29.63 | 5 | 122526 | 129215 | 79492642 |
| Ovarian cyst ruptured | 174.64 | 29.63 | 63 | 122468 | 903 | 79620954 |
| Therapeutic product effect incomplete | 173.98 | 29.63 | 11 | 122520 | 141634 | 79480223 |
| Intentional product use issue | 172.36 | 29.63 | 17 | 122514 | 152095 | 79469762 |
| Product use in unapproved indication | 171.72 | 29.63 | 85 | 122446 | 250274 | 79371583 |
| Oxygen saturation decreased | 171.45 | 29.63 | 6 | 122525 | 129041 | 79492816 |
| Oedema peripheral | 171.03 | 29.63 | 87 | 122444 | 252201 | 79369656 |
| Swelling | 168.76 | 29.63 | 61 | 122470 | 216650 | 79405207 |
| Retained products of conception | 168.11 | 29.63 | 39 | 122492 | 87 | 79621770 |
| Pruritus | 168.05 | 29.63 | 216 | 122315 | 394432 | 79227425 |
| Hypertrichosis | 167.76 | 29.63 | 66 | 122465 | 1216 | 79620641 |
| Suppressed lactation | 166.82 | 29.63 | 47 | 122484 | 280 | 79621577 |
| Vulvovaginal pain | 166.59 | 29.63 | 77 | 122454 | 2138 | 79619719 |
| Oestrogen receptor assay positive | 166.39 | 29.63 | 47 | 122484 | 283 | 79621574 |
| Uterine cervical pain | 164.47 | 29.63 | 32 | 122499 | 13 | 79621844 |
| Bacterial vaginosis | 164.46 | 29.63 | 64 | 122467 | 1144 | 79620713 |
| Vaginal infection | 164.08 | 29.63 | 106 | 122425 | 5774 | 79616083 |
| Intentional medical device removal by patient | 163.37 | 29.63 | 48 | 122483 | 339 | 79621518 |
| Haemorrhagic ovarian cyst | 162.48 | 29.63 | 54 | 122477 | 596 | 79621261 |
| Blood pressure increased | 162.04 | 29.63 | 61 | 122470 | 211299 | 79410558 |
| Psychological trauma | 161.86 | 29.63 | 66 | 122465 | 1340 | 79620517 |
| Musculoskeletal stiffness | 160.74 | 29.63 | 36 | 122495 | 174972 | 79446885 |
| Breast cancer | 159.97 | 29.63 | 227 | 122304 | 33554 | 79588303 |
| Wound | 159.45 | 29.63 | 4 | 122527 | 116175 | 79505682 |
| Uterine infection | 157.78 | 29.63 | 44 | 122487 | 251 | 79621606 |
| Pain in extremity | 156.77 | 29.63 | 198 | 122333 | 364340 | 79257517 |
| Diffuse alopecia | 155.69 | 29.63 | 58 | 122473 | 915 | 79620942 |
| Myocardial infarction | 155.42 | 29.63 | 45 | 122486 | 184084 | 79437773 |
| Chest pain | 154.89 | 29.63 | 124 | 122407 | 282180 | 79339677 |
| Nausea | 154.65 | 29.63 | 853 | 121678 | 956343 | 78665514 |
| Pelvic fluid collection | 154.03 | 29.63 | 55 | 122476 | 764 | 79621093 |
| Pelvic adhesions | 153.07 | 29.63 | 43 | 122488 | 253 | 79621604 |
| Wheezing | 153 | 29.63 | 6 | 122525 | 116658 | 79505199 |
| Multiple organ dysfunction syndrome | 151.77 | 29.63 | 8 | 122523 | 120238 | 79501619 |
| Tubo-ovarian abscess | 151.22 | 29.63 | 44 | 122487 | 299 | 79621558 |
| Hyperkalaemia | 149.63 | 29.63 | 6 | 122525 | 114392 | 79507465 |
| Gait disturbance | 149.15 | 29.63 | 66 | 122465 | 207440 | 79414417 |
| Mood altered | 147.94 | 29.63 | 159 | 122372 | 17688 | 79604169 |
| Device malfunction | 145.24 | 29.63 | 172 | 122359 | 21276 | 79600581 |
| Bradycardia | 141.57 | 29.63 | 20 | 122511 | 135537 | 79486320 |
| Cardio-respiratory arrest | 140.89 | 29.63 | 6 | 122525 | 108504 | 79513353 |
| Irritability | 140.85 | 29.63 | 238 | 122293 | 40906 | 79580951 |
| Intentional overdose | 140.50 | 29.63 | 5 | 122526 | 105955 | 79515902 |
| Systemic lupus erythematosus | 138.67 | 29.63 | 13 | 122518 | 121136 | 79500721 |
| Pemphigus | 138.31 | 29.63 | 3 | 122528 | 99579 | 79522278 |
| Hydrometra | 137.88 | 29.63 | 29 | 122502 | 31 | 79621826 |
| Hypoxia | 136.45 | 29.63 | 5 | 122526 | 103238 | 79518619 |
| Rhabdomyolysis | 136.28 | 29.63 | 5 | 122526 | 103126 | 79518731 |
| Hirsutism | 135.96 | 29.63 | 58 | 122473 | 1324 | 79620533 |
| COVID-19 | 135.92 | 29.63 | 37 | 122494 | 157637 | 79464220 |
| Contusion | 135.82 | 29.63 | 31 | 122500 | 148745 | 79473112 |
| Leukopenia | 134.71 | 29.63 | 12 | 122519 | 116501 | 79505356 |
| Injection site pain | 133.63 | 29.63 | 20 | 122511 | 129818 | 79492039 |
| Depressed level of consciousness | 130.14 | 29.63 | 4 | 122527 | 96648 | 79525209 |
| Alanine aminotransferase increased | 129.57 | 29.63 | 44 | 122487 | 162526 | 79459331 |
| Presyncope | 129.44 | 29.63 | 229 | 122302 | 40825 | 79581032 |
| Hypoglycaemia | 127.46 | 29.63 | 7 | 122524 | 101587 | 79520270 |
| Blood glucose increased | 127.28 | 29.63 | 14 | 122517 | 114961 | 79506896 |
| Procedural nausea | 126.70 | 29.63 | 48 | 122483 | 795 | 79621062 |
| Bronchitis | 125.89 | 29.63 | 24 | 122507 | 130620 | 79491237 |
| Smear cervix abnormal | 124.66 | 29.63 | 66 | 122465 | 2470 | 79619387 |
| Haematosalpinx | 123.22 | 29.63 | 23 | 122508 | 3 | 79621854 |
| Pregnancy with implant contraceptive | 122.61 | 29.63 | 59 | 122472 | 1797 | 79620060 |
| Panic attack | 122.52 | 29.63 | 168 | 122363 | 24048 | 79597809 |
| Influenza | 122.39 | 29.63 | 25 | 122506 | 129581 | 79492276 |
| Chlamydial infection | 122.24 | 29.63 | 42 | 122489 | 517 | 79621340 |
| Arthritis | 122.21 | 29.63 | 16 | 122515 | 114864 | 79506993 |
| Cellulitis | 121.44 | 29.63 | 13 | 122518 | 109047 | 79512810 |
| Product shape issue | 120.79 | 29.63 | 26 | 122505 | 34 | 79621823 |
| Impaired healing | 120.34 | 29.63 | 3 | 122528 | 87652 | 79534205 |
| Epistaxis | 119.91 | 29.63 | 15 | 122516 | 111500 | 79510357 |
| Asthma | 119.68 | 29.63 | 30 | 122501 | 135065 | 79486792 |
| C-reactive protein increased | 119.56 | 29.63 | 26 | 122505 | 129001 | 79492856 |
| Neutrophil count decreased | 119.37 | 29.63 | 6 | 122525 | 93953 | 79527904 |
| Muscular weakness | 117.26 | 29.63 | 50 | 122481 | 160679 | 79461178 |
| Patient-device incompatibility | 116.90 | 29.63 | 30 | 122501 | 117 | 79621740 |
| Abortion missed | 116.89 | 29.63 | 51 | 122480 | 1232 | 79620625 |
| Aspartate aminotransferase increased | 116.77 | 29.63 | 34 | 122497 | 138607 | 79483250 |
| Drug ineffective | 116.04 | 29.63 | 2314 | 120217 | 1078599 | 78543258 |
| Product use issue | 115.25 | 29.63 | 92 | 122439 | 209730 | 79412127 |
| Oedema | 115.15 | 29.63 | 22 | 122509 | 119558 | 79502299 |
| Gynaecological chlamydia infection | 115.08 | 29.63 | 21 | 122510 | 0 | 79621857 |
| Loop electrosurgical excision procedure | 113.47 | 29.63 | 24 | 122507 | 27 | 79621830 |
| Septic shock | 113.27 | 29.63 | 25 | 122506 | 122776 | 79499081 |
| Uterine polyp | 112.73 | 29.63 | 53 | 122478 | 1531 | 79620326 |
| Inappropriate schedule of product administration | 112.12 | 29.63 | 33 | 122498 | 133595 | 79488262 |
| Uterine injury | 112.10 | 29.63 | 24 | 122507 | 30 | 79621827 |
| Productive cough | 111.08 | 29.63 | 6 | 122525 | 88325 | 79533532 |
| Weight increased | 110.34 | 29.63 | 767 | 121764 | 276619 | 79345238 |
| Osteoarthritis | 109.58 | 29.63 | 6 | 122525 | 87303 | 79534554 |
| Cervicitis | 109.53 | 29.63 | 32 | 122499 | 221 | 79621636 |
| Blister | 108.84 | 29.63 | 25 | 122506 | 119451 | 79502406 |
| Mobility decreased | 108.48 | 29.63 | 27 | 122504 | 122148 | 79499709 |
| Vulvovaginal discomfort | 108.18 | 29.63 | 54 | 122477 | 1784 | 79620073 |
| Peritoneal adhesions | 107.05 | 29.63 | 34 | 122497 | 321 | 79621536 |
| Uterine enlargement | 105.81 | 29.63 | 43 | 122488 | 865 | 79620992 |
| Dysphagia | 104.62 | 29.63 | 29 | 122502 | 122107 | 79499750 |
| Medical device site discomfort | 103.99 | 29.63 | 30 | 122501 | 197 | 79621660 |
| Herpes zoster | 103.88 | 29.63 | 11 | 122520 | 93072 | 79528785 |
| Oropharyngeal pain | 103.44 | 29.63 | 21 | 122510 | 109332 | 79512525 |
| Therapy non-responder | 102.78 | 29.63 | 11 | 122520 | 92294 | 79529563 |
| Device intolerance | 102.70 | 29.63 | 25 | 122506 | 74 | 79621783 |
| Mucosal inflammation | 102.22 | 29.63 | 3 | 122528 | 75577 | 79546280 |
| Cervical polyp | 99.95 | 29.63 | 27 | 122504 | 134 | 79621723 |
| Hallucination | 98.66 | 29.63 | 9 | 122522 | 85736 | 79536121 |
| Hepatic function abnormal | 98.51 | 29.63 | 3 | 122528 | 73104 | 79548753 |
| Hospitalisation | 98.16 | 29.63 | 14 | 122517 | 94222 | 79527635 |
| Hormone level abnormal | 98.12 | 29.63 | 52 | 122479 | 1950 | 79619907 |
| Cervix disorder | 97.15 | 29.63 | 30 | 122501 | 256 | 79621601 |
| Pelvic infection | 96.38 | 29.63 | 32 | 122499 | 352 | 79621505 |
| Adenomyosis | 95.73 | 29.63 | 30 | 122501 | 270 | 79621587 |
| Intentional product misuse | 94.89 | 29.63 | 16 | 122515 | 95149 | 79526708 |
| Pulmonary oedema | 94.57 | 29.63 | 12 | 122519 | 88242 | 79533615 |
| Agitation | 92.57 | 29.63 | 20 | 122511 | 99695 | 79522162 |
| Lung disorder | 91.24 | 29.63 | 9 | 122522 | 80548 | 79541309 |
| Diabetes mellitus | 90.81 | 29.63 | 8 | 122523 | 78382 | 79543475 |
| Uterine cervical laceration | 89.57 | 29.63 | 17 | 122514 | 4 | 79621853 |
| Uterine adhesions | 88.64 | 29.63 | 19 | 122512 | 24 | 79621833 |
| Procedural anxiety | 88.32 | 29.63 | 36 | 122495 | 730 | 79621127 |
| Hyperglycaemia | 87.75 | 29.63 | 5 | 122526 | 70330 | 79551527 |
| Encephalopathy | 86.58 | 29.63 | 4 | 122527 | 67393 | 79554464 |
| Dyspnoea exertional | 86.03 | 29.63 | 15 | 122516 | 87058 | 79534799 |
| Blood cholesterol increased | 85.90 | 29.63 | 13 | 122518 | 83707 | 79538150 |
| Heart rate increased | 85.77 | 29.63 | 39 | 122492 | 120685 | 79501172 |
| Uterine inflammation | 85.70 | 29.63 | 18 | 122513 | 19 | 79621838 |
| Dry mouth | 85.15 | 29.63 | 16 | 122515 | 88003 | 79533854 |
| Colposcopy | 84.93 | 29.63 | 16 | 122515 | 3 | 79621854 |
| Ill-defined disorder | 84.34 | 29.63 | 4 | 122527 | 65871 | 79555986 |
| Endometrial hyperplasia | 84.13 | 29.63 | 33 | 122498 | 603 | 79621254 |
| Procedural vomiting | 83.83 | 29.63 | 35 | 122496 | 756 | 79621101 |
| Abdominal distension | 83.58 | 29.63 | 385 | 122146 | 119265 | 79502592 |
| Tremor | 83.27 | 29.63 | 83 | 122448 | 170000 | 79451857 |
| Nasal congestion | 83.02 | 29.63 | 10 | 122521 | 76542 | 79545315 |
| Blood pressure systolic increased | 82.84 | 29.63 | 5 | 122526 | 66981 | 79554876 |
| Psoriatic arthropathy | 82.63 | 29.63 | 11 | 122520 | 77988 | 79543869 |
| Focal nodular hyperplasia | 82.58 | 29.63 | 34 | 122497 | 708 | 79621149 |
| Genital discharge | 82.43 | 29.63 | 17 | 122514 | 15 | 79621842 |
| Chronic kidney disease | 81.63 | 29.63 | 5 | 122526 | 66149 | 79555708 |
| Post abortion haemorrhage | 81.47 | 29.63 | 20 | 122511 | 62 | 79621795 |
| Hepatic failure | 80.75 | 29.63 | 3 | 122528 | 61209 | 79560648 |
| Coronary artery disease | 80.63 | 29.63 | 5 | 122526 | 65469 | 79556388 |
| Injection site erythema | 80.56 | 29.63 | 12 | 122519 | 78185 | 79543672 |
| Pneumonitis | 80.23 | 29.63 | 3 | 122528 | 60857 | 79561000 |
| Pregnancy after post coital contraception | 79.47 | 29.63 | 15 | 122516 | 3 | 79621854 |
| Lactic acidosis | 79.32 | 29.63 | 8 | 122523 | 70351 | 79551506 |
| Device ineffective | 79.08 | 29.63 | 23 | 122508 | 156 | 79621701 |
| Acute respiratory failure | 78.27 | 29.63 | 3 | 122528 | 59538 | 79562319 |
| Gastrointestinal disorder | 77.15 | 29.63 | 46 | 122485 | 122159 | 79499698 |
| Mental status changes | 77.11 | 29.63 | 7 | 122524 | 66952 | 79554905 |
| Acute myocardial infarction | 76.70 | 29.63 | 13 | 122518 | 77023 | 79544834 |
| Chills | 76.39 | 29.63 | 80 | 122451 | 160154 | 79461703 |
| Drug-induced liver injury | 75.90 | 29.63 | 7 | 122524 | 66110 | 79555747 |
| Upper respiratory tract infection | 75.59 | 29.63 | 23 | 122508 | 91145 | 79530712 |
| Colitis | 73.81 | 29.63 | 12 | 122519 | 73295 | 79548562 |
| Urinary tract infection | 73.51 | 29.63 | 199 | 122332 | 274313 | 79347544 |
| Gastrointestinal injury | 73.39 | 29.63 | 34 | 122497 | 949 | 79620908 |
| Rhinorrhoea | 73.22 | 29.63 | 14 | 122517 | 76060 | 79545797 |
| Abdominal discomfort | 73.13 | 29.63 | 174 | 122357 | 250553 | 79371304 |
| Uterine tenderness | 72.86 | 29.63 | 15 | 122516 | 13 | 79621844 |
| Blood pressure fluctuation | 72.26 | 29.63 | 9 | 122522 | 67136 | 79554721 |
| Gastrooesophageal reflux disease | 72.01 | 29.63 | 35 | 122496 | 104211 | 79517646 |
| Chlamydia test positive | 71.90 | 29.63 | 16 | 122515 | 27 | 79621830 |
| Incorrect dose administered | 71.88 | 29.63 | 15 | 122516 | 76615 | 79545242 |
| Therapeutic response decreased | 71.85 | 29.63 | 9 | 122522 | 66844 | 79555013 |
| Pregnancy test positive | 71.59 | 29.63 | 19 | 122512 | 87 | 79621770 |
| Patient dissatisfaction with device | 71.24 | 29.63 | 13 | 122518 | 0 | 79621857 |
| Haematochezia | 71.07 | 29.63 | 23 | 122508 | 87622 | 79534235 |
| Human chorionic gonadotropin decreased | 71.05 | 29.63 | 14 | 122517 | 7 | 79621850 |
| Blood creatine phosphokinase increased | 70.78 | 29.63 | 9 | 122522 | 66081 | 79555776 |
| Liver injury | 70.70 | 29.63 | 4 | 122527 | 56610 | 79565247 |
| Cataract | 70.19 | 29.63 | 7 | 122524 | 62113 | 79559744 |
| Endometrial cancer | 69.12 | 29.63 | 42 | 122489 | 2052 | 79619805 |
| Red blood cell count decreased | 69.04 | 29.63 | 5 | 122526 | 57508 | 79564349 |
| Benign hydatidiform mole | 69.00 | 29.63 | 18 | 122513 | 76 | 79621781 |
| Salpingo-oophoritis | 68.94 | 29.63 | 19 | 122512 | 103 | 79621754 |
| Inflammation | 68.63 | 29.63 | 29 | 122502 | 93724 | 79528133 |
| Hepatic adenoma | 68.38 | 29.63 | 24 | 122507 | 316 | 79621541 |
| Chest discomfort | 67.99 | 29.63 | 67 | 122464 | 137977 | 79483880 |
| Endometrial thickening | 67.62 | 29.63 | 23 | 122508 | 274 | 79621583 |
| Maternal exposure during pregnancy | 67.55 | 29.63 | 66 | 122465 | 136472 | 79485385 |
| Rectal haemorrhage | 67.45 | 29.63 | 17 | 122514 | 76283 | 79545574 |
| Papilloedema | 67.16 | 29.63 | 64 | 122467 | 6169 | 79615688 |
| Skin ulcer | 67.09 | 29.63 | 4 | 122527 | 54146 | 79567711 |
| Cerebrovascular accident | 67.01 | 29.63 | 84 | 122447 | 155208 | 79466649 |
| Rash maculo-papular | 66.96 | 29.63 | 5 | 122526 | 56073 | 79565784 |
| Genital pain | 66.58 | 29.63 | 30 | 122501 | 784 | 79621073 |
| Medical device entrapment | 65.76 | 29.63 | 12 | 122519 | 0 | 79621857 |
| Uterine contractions abnormal | 65.19 | 29.63 | 19 | 122512 | 130 | 79621727 |
| Vulvovaginal pruritus | 65.06 | 29.63 | 44 | 122487 | 2589 | 79619268 |
| Orthostatic hypotension | 64.33 | 29.63 | 6 | 122525 | 56158 | 79565699 |
| Wrong technique in product usage process | 64.27 | 29.63 | 17 | 122514 | 73858 | 79547999 |
| Osteoporosis | 64.12 | 29.63 | 5 | 122526 | 54107 | 79567750 |
| Cerebral haemorrhage | 63.88 | 29.63 | 7 | 122524 | 57666 | 79564191 |
| Sedation | 63.79 | 29.63 | 4 | 122527 | 51891 | 79569966 |
| Haematuria | 63.49 | 29.63 | 14 | 122517 | 68822 | 79553035 |
| Heart rate decreased | 63.46 | 29.63 | 15 | 122516 | 70301 | 79551556 |
| Adnexa uteri cyst | 63.04 | 29.63 | 15 | 122516 | 39 | 79621818 |
| Procedural complication | 62.46 | 29.63 | 69 | 122462 | 7914 | 79613943 |
| Pregnancy on oral contraceptive | 62.38 | 29.63 | 29 | 122502 | 816 | 79621041 |
| Complication of pregnancy | 62.02 | 29.63 | 23 | 122508 | 358 | 79621499 |
| Cervical cyst | 61.63 | 29.63 | 16 | 122515 | 66 | 79621791 |
| Unresponsive to stimuli | 61.21 | 29.63 | 7 | 122524 | 55781 | 79566076 |
| Vulvovaginal mycotic infection | 61.20 | 29.63 | 53 | 122478 | 4513 | 79617344 |
| Hypocalcaemia | 60.92 | 29.63 | 4 | 122527 | 49920 | 79571937 |
| Actinomyces test positive | 60.90 | 29.63 | 12 | 122519 | 6 | 79621851 |
| Irritable bowel syndrome | 60.88 | 29.63 | 11 | 122520 | 62230 | 79559627 |
| Breast discharge | 60.77 | 29.63 | 27 | 122504 | 682 | 79621175 |
| Blood pressure decreased | 60.62 | 29.63 | 39 | 122492 | 99427 | 79522430 |
| Seborrhoea | 60.56 | 29.63 | 24 | 122507 | 451 | 79621406 |
| Liver disorder | 60.52 | 29.63 | 18 | 122513 | 72399 | 79549458 |
| Habitual abortion | 60.28 | 29.63 | 11 | 122520 | 0 | 79621857 |
| Cervix injury | 60.28 | 29.63 | 11 | 122520 | 0 | 79621857 |
| White blood cell count increased | 59.79 | 29.63 | 20 | 122511 | 74613 | 79547244 |
| Abdominal adhesions | 59.42 | 29.63 | 47 | 122484 | 3526 | 79618331 |
| Cardiac disorder | 59.40 | 29.63 | 14 | 122517 | 65743 | 79556114 |
| Hepatitis | 58.69 | 29.63 | 8 | 122523 | 55719 | 79566138 |
| Folliculitis | 58.20 | 29.63 | 8 | 122523 | 55372 | 79566485 |
| Blood bilirubin increased | 58.08 | 29.63 | 15 | 122516 | 66217 | 79555640 |
| Dyspepsia | 57.98 | 29.63 | 49 | 122482 | 108638 | 79513219 |
| Retained placenta or membranes | 57.50 | 29.63 | 20 | 122511 | 256 | 79621601 |
| Hepatotoxicity | 57.47 | 29.63 | 6 | 122525 | 51346 | 79570511 |
| Eosinophilia | 57.26 | 29.63 | 3 | 122528 | 45342 | 79576515 |
| Oligomenorrhoea | 56.99 | 29.63 | 26 | 122505 | 700 | 79621157 |
| Breast swelling | 56.98 | 29.63 | 32 | 122499 | 1348 | 79620509 |
| Agranulocytosis | 56.79 | 29.63 | 3 | 122528 | 45027 | 79576830 |
| Lethargy | 56.59 | 29.63 | 27 | 122504 | 81265 | 79540592 |
| Fallopian tube disorder | 56.54 | 29.63 | 22 | 122509 | 393 | 79621464 |
| Anembryonic gestation | 56.49 | 29.63 | 22 | 122509 | 394 | 79621463 |
| Respiratory tract infection | 56.31 | 29.63 | 5 | 122526 | 48684 | 79573173 |
| Haematemesis | 56.25 | 29.63 | 7 | 122524 | 52257 | 79569600 |
| Intentional device use issue | 56.18 | 29.63 | 14 | 122517 | 47 | 79621810 |
| Toxic epidermal necrolysis | 56.13 | 29.63 | 3 | 122528 | 44578 | 79577279 |
| Type 2 diabetes mellitus | 56.07 | 29.63 | 10 | 122521 | 57112 | 79564745 |
| Pulmonary hypertension | 55.43 | 29.63 | 5 | 122526 | 48075 | 79573782 |
| Acute respiratory distress syndrome | 55.38 | 29.63 | 3 | 122528 | 44064 | 79577793 |
| Drug eruption | 55.18 | 29.63 | 3 | 122528 | 43932 | 79577925 |
| Cervix carcinoma stage 0 | 55.14 | 29.63 | 19 | 122512 | 236 | 79621621 |
| Dysphonia | 53.61 | 29.63 | 11 | 122520 | 56861 | 79564996 |
| Disorientation | 53.57 | 29.63 | 15 | 122516 | 62761 | 79559096 |
| Seizure | 53.51 | 29.63 | 133 | 122398 | 188701 | 79433156 |
| Fear of disease | 53.45 | 29.63 | 30 | 122501 | 1262 | 79620595 |
| Breast cancer in situ | 53.35 | 29.63 | 27 | 122504 | 919 | 79620938 |
| Cytomegalovirus infection | 53.29 | 29.63 | 3 | 122528 | 42641 | 79579216 |
| Renal disorder | 52.50 | 29.63 | 3 | 122528 | 42102 | 79579755 |
| Migraine with aura | 52.48 | 29.63 | 39 | 122492 | 2666 | 79619191 |
| Cervical conisation | 52.18 | 29.63 | 10 | 122521 | 3 | 79621854 |
| Hypophagia | 51.55 | 29.63 | 5 | 122526 | 45362 | 79576495 |
| Cholestasis | 51.42 | 29.63 | 9 | 122522 | 52100 | 79569757 |
| Musculoskeletal pain | 51.18 | 29.63 | 49 | 122482 | 102305 | 79519552 |
| Vertigo | 51.00 | 29.63 | 226 | 122305 | 68856 | 79553001 |
| Cervix haemorrhage uterine | 50.84 | 29.63 | 11 | 122520 | 15 | 79621842 |
| Progesterone decreased | 50.77 | 29.63 | 12 | 122519 | 30 | 79621827 |
| Flushing | 50.61 | 29.63 | 37 | 122494 | 88231 | 79533626 |
| Pancreatitis | 50.53 | 29.63 | 21 | 122510 | 68554 | 79553303 |
| Uterine haematoma | 50.43 | 29.63 | 11 | 122520 | 16 | 79621841 |
| Clostridium difficile infection | 50.42 | 29.63 | 4 | 122527 | 42681 | 79579176 |
| Full blood count abnormal | 50.11 | 29.63 | 3 | 122528 | 40471 | 79581386 |
| Pelvic organ injury | 50.11 | 29.63 | 10 | 122521 | 6 | 79621851 |
| Red blood cell sedimentation rate increased | 49.82 | 29.63 | 6 | 122525 | 45936 | 79575921 |
| Hepatocellular injury | 49.72 | 29.63 | 7 | 122524 | 47586 | 79574271 |
| Staphylococcal infection | 49.61 | 29.63 | 14 | 122517 | 58281 | 79563576 |
| Psoriasis | 49.51 | 29.63 | 39 | 122492 | 89548 | 79532309 |
| Treatment noncompliance | 49.50 | 29.63 | 10 | 122521 | 52258 | 79569599 |
| Myalgia | 49.35 | 29.63 | 135 | 122396 | 185506 | 79436351 |
| Uterine fibrosis | 49.32 | 29.63 | 9 | 122522 | 0 | 79621857 |
| Chlamydial pelvic inflammatory disease | 49.32 | 29.63 | 9 | 122522 | 0 | 79621857 |
| Fallopian tube perforation | 49.32 | 29.63 | 9 | 122522 | 0 | 79621857 |
| Tachycardia | 48.98 | 29.63 | 127 | 122404 | 177641 | 79444216 |
| Product contamination | 48.74 | 29.63 | 28 | 122503 | 1232 | 79620625 |
| Fibromyalgia | 48.55 | 29.63 | 19 | 122512 | 64321 | 79557536 |
| Ovarian germ cell teratoma benign | 48.46 | 29.63 | 12 | 122519 | 39 | 79621818 |
| Insomnia | 48.33 | 29.63 | 203 | 122328 | 244967 | 79376890 |
| Respiratory disorder | 48.29 | 29.63 | 6 | 122525 | 44850 | 79577007 |
| Joint stiffness | 47.74 | 29.63 | 4 | 122527 | 40826 | 79581031 |
| Blood alkaline phosphatase increased | 47.71 | 29.63 | 19 | 122512 | 63645 | 79558212 |
| Dizziness | 47.40 | 29.63 | 549 | 121982 | 525892 | 79095965 |
| Ovarian vein thrombosis | 47.34 | 29.63 | 12 | 122519 | 44 | 79621813 |
| Skin exfoliation | 47.33 | 29.63 | 13 | 122518 | 55087 | 79566770 |
| Liver function test abnormal | 47.09 | 29.63 | 20 | 122511 | 64455 | 79557402 |
| Mouth ulceration | 47.07 | 29.63 | 3 | 122528 | 38391 | 79583466 |
| Genito-pelvic pain/penetration disorder | 46.73 | 29.63 | 9 | 122522 | 3 | 79621854 |
| Cervix inflammation | 46.73 | 29.63 | 9 | 122522 | 3 | 79621854 |
| Fallopian tube cyst | 46.52 | 29.63 | 12 | 122519 | 48 | 79621809 |
| Haematocrit decreased | 46.44 | 29.63 | 18 | 122513 | 61294 | 79560563 |
| Leukocytosis | 46.33 | 29.63 | 6 | 122525 | 43449 | 79578408 |
| Invasive ductal breast carcinoma | 46.22 | 29.63 | 51 | 122480 | 5841 | 79616016 |
| Pelvic haemorrhage | 46.19 | 29.63 | 15 | 122516 | 153 | 79621704 |
| Cognitive disorder | 46.02 | 29.63 | 25 | 122506 | 69901 | 79551956 |
| Illness | 45.97 | 29.63 | 8 | 122523 | 46503 | 79575354 |
| Localised infection | 45.88 | 29.63 | 3 | 122528 | 37572 | 79584285 |
| Therapy cessation | 45.86 | 29.63 | 3 | 122528 | 37559 | 79584298 |
| Chloasma | 45.85 | 29.63 | 11 | 122520 | 30 | 79621827 |
| Loss of personal independence in daily activities | 45.82 | 29.63 | 54 | 122477 | 102526 | 79519331 |
| Breast discomfort | 45.74 | 29.63 | 19 | 122512 | 405 | 79621452 |
| Diverticulitis | 45.18 | 29.63 | 8 | 122523 | 45928 | 79575929 |
| Abortion induced | 44.84 | 29.63 | 55 | 122476 | 7054 | 79614803 |
| Transaminases increased | 44.83 | 29.63 | 12 | 122519 | 51731 | 79570126 |
| Injection site pruritus | 44.69 | 29.63 | 6 | 122525 | 42277 | 79579580 |
| Bone pain | 44.54 | 29.63 | 15 | 122516 | 55727 | 79566130 |
| Hypercalcaemia | 44.29 | 29.63 | 4 | 122527 | 38426 | 79583431 |
| Balance disorder | 44.20 | 29.63 | 52 | 122479 | 98805 | 79523052 |
| Ectopic pregnancy under hormonal contraception | 43.84 | 29.63 | 8 | 122523 | 0 | 79621857 |
| Biopsy endometrium | 43.84 | 29.63 | 8 | 122523 | 0 | 79621857 |
| Cervical discharge | 43.84 | 29.63 | 8 | 122523 | 0 | 79621857 |
| Gastritis | 43.78 | 29.63 | 10 | 122521 | 47983 | 79573874 |
| Haematoma | 43.56 | 29.63 | 13 | 122518 | 52182 | 79569675 |
| Caesarean section | 43.54 | 29.63 | 73 | 122458 | 12462 | 79609395 |
| Bursitis | 43.36 | 29.63 | 3 | 122528 | 35841 | 79586016 |
| Pain in jaw | 43.35 | 29.63 | 9 | 122522 | 46142 | 79575715 |
| Haemoptysis | 43.15 | 29.63 | 16 | 122515 | 55983 | 79565874 |
| Vulvovaginal dryness | 43.00 | 29.63 | 32 | 122499 | 2192 | 79619665 |
| Papilloma viral infection | 42.90 | 29.63 | 29 | 122502 | 1705 | 79620152 |
| Endometrial atrophy | 42.84 | 29.63 | 11 | 122520 | 43 | 79621814 |
| Abnormal withdrawal bleeding | 42.64 | 29.63 | 11 | 122520 | 44 | 79621813 |
| Injection site swelling | 42.64 | 29.63 | 10 | 122521 | 47122 | 79574735 |
| Urinary retention | 42.28 | 29.63 | 17 | 122514 | 56613 | 79565244 |
| Hepatic cirrhosis | 41.99 | 29.63 | 3 | 122528 | 34903 | 79586954 |
| Blood potassium decreased | 41.82 | 29.63 | 10 | 122521 | 46502 | 79575355 |
| Injection site reaction | 41.63 | 29.63 | 16 | 122515 | 54769 | 79567088 |
| Gonorrhoea | 41.33 | 29.63 | 15 | 122516 | 219 | 79621638 |
| Abortion spontaneous incomplete | 41.29 | 29.63 | 9 | 122522 | 13 | 79621844 |
| Endometrial hypertrophy | 40.92 | 29.63 | 14 | 122517 | 170 | 79621687 |
| Anaphylactic reaction | 40.81 | 29.63 | 41 | 122490 | 83702 | 79538155 |
| Adnexal torsion | 40.77 | 29.63 | 17 | 122514 | 366 | 79621491 |
| Hepatic steatosis | 40.74 | 29.63 | 5 | 122526 | 37733 | 79584124 |
| Injection site bruising | 40.63 | 29.63 | 7 | 122524 | 40995 | 79580862 |
| Pancreatitis acute | 40.24 | 29.63 | 13 | 122518 | 49591 | 79572266 |
| Subchorionic haemorrhage | 40.09 | 29.63 | 13 | 122518 | 132 | 79621725 |
| Road traffic accident | 40.03 | 29.63 | 9 | 122522 | 43655 | 79578202 |
| Suicide attempt | 39.97 | 29.63 | 41 | 122490 | 82891 | 79538966 |
| Rash pruritic | 39.81 | 29.63 | 31 | 122500 | 71598 | 79550259 |
| Acne cystic | 39.78 | 29.63 | 19 | 122512 | 569 | 79621288 |
| Joint range of motion decreased | 39.64 | 29.63 | 3 | 122528 | 33279 | 79588578 |
| Infertility | 39.51 | 29.63 | 20 | 122511 | 681 | 79621176 |
| Placenta accreta | 38.91 | 29.63 | 14 | 122517 | 199 | 79621658 |
| Influenza like illness | 38.64 | 29.63 | 32 | 122499 | 71675 | 79550182 |
| Negative thoughts | 38.49 | 29.63 | 25 | 122506 | 1374 | 79620483 |
| Drug dependence | 38.19 | 29.63 | 8 | 122523 | 40761 | 79581096 |
| Stevens-Johnson syndrome | 38.13 | 29.63 | 7 | 122524 | 39159 | 79582698 |
| Breast cyst | 37.89 | 29.63 | 24 | 122507 | 1263 | 79620594 |
| Gastric ulcer | 37.84 | 29.63 | 4 | 122527 | 33901 | 79587956 |
| Ventricular fibrillation | 37.68 | 29.63 | 3 | 122528 | 31923 | 79589934 |
| Loss of consciousness | 37.63 | 29.63 | 132 | 122399 | 167811 | 79454046 |
| Pelvic abscess | 37.32 | 29.63 | 29 | 122502 | 2120 | 79619737 |
| Sinus tachycardia | 37.24 | 29.63 | 6 | 122525 | 36902 | 79584955 |
| Therapy interrupted | 36.84 | 29.63 | 3 | 122528 | 31338 | 79590519 |
| Ascites | 36.82 | 29.63 | 37 | 122494 | 75525 | 79546332 |
| Underdose | 36.77 | 29.63 | 4 | 122527 | 33147 | 79588710 |
| Sleep apnoea syndrome | 36.65 | 29.63 | 6 | 122525 | 36472 | 79585385 |
| Drug withdrawal syndrome | 36.52 | 29.63 | 5 | 122526 | 34713 | 79587144 |
| Maternal exposure before pregnancy | 36.31 | 29.63 | 39 | 122492 | 4334 | 79617523 |
| Bacteraemia | 36.31 | 29.63 | 4 | 122527 | 32820 | 79589037 |
| Electrolyte imbalance | 36.18 | 29.63 | 3 | 122528 | 30878 | 79590979 |
| Rash erythematous | 36.09 | 29.63 | 22 | 122509 | 57747 | 79564110 |
| Endometrial disorder | 35.94 | 29.63 | 18 | 122513 | 599 | 79621258 |
| Head injury | 35.70 | 29.63 | 7 | 122524 | 37362 | 79584495 |
| Skin lesion | 35.70 | 29.63 | 10 | 122521 | 41834 | 79580023 |
| Lymphocyte count decreased | 35.62 | 29.63 | 14 | 122517 | 47275 | 79574582 |
| Atelectasis | 35.51 | 29.63 | 4 | 122527 | 32253 | 79589604 |
| Memory impairment | 35.45 | 29.63 | 74 | 122457 | 111660 | 79510197 |
| Dysarthria | 35.43 | 29.63 | 31 | 122500 | 67591 | 79554266 |
| Viral infection | 35.38 | 29.63 | 11 | 122520 | 43005 | 79578852 |
| Acute abdomen | 35.31 | 29.63 | 33 | 122498 | 3104 | 79618753 |
| Menopausal symptoms | 35.20 | 29.63 | 27 | 122504 | 1936 | 79619921 |
| Ulcer | 34.87 | 29.63 | 3 | 122528 | 29969 | 79591888 |
| Angina pectoris | 34.77 | 29.63 | 18 | 122513 | 51714 | 79570143 |
| Cyst | 34.67 | 29.63 | 70 | 122461 | 13770 | 79608087 |
| Uterine disorder | 34.50 | 29.63 | 28 | 122503 | 2179 | 79619678 |
| Blood sodium decreased | 34.49 | 29.63 | 5 | 122526 | 33250 | 79588607 |
| Oral candidiasis | 34.37 | 29.63 | 3 | 122528 | 29625 | 79592232 |
| Joint injury | 34.20 | 29.63 | 4 | 122527 | 31331 | 79590526 |
| Dyskinesia | 34.15 | 29.63 | 13 | 122518 | 44760 | 79577097 |
| Neutrophil count increased | 34.04 | 29.63 | 3 | 122528 | 29393 | 79592464 |
| Hydrosalpinx | 34.03 | 29.63 | 7 | 122524 | 6 | 79621851 |
| Blood potassium increased | 33.87 | 29.63 | 3 | 122528 | 29272 | 79592585 |
| Osteonecrosis | 33.87 | 29.63 | 4 | 122527 | 31091 | 79590766 |
| Adnexa uteri mass | 33.76 | 29.63 | 15 | 122516 | 379 | 79621478 |
| Amniotic cavity infection | 33.66 | 29.63 | 19 | 122512 | 808 | 79621049 |
| Toxic shock syndrome streptococcal | 33.38 | 29.63 | 11 | 122520 | 118 | 79621739 |
| Uterine cyst | 33.38 | 29.63 | 14 | 122517 | 306 | 79621551 |
| Disease recurrence | 33.32 | 29.63 | 13 | 122518 | 44096 | 79577761 |
| Actinomycosis | 33.27 | 29.63 | 21 | 122510 | 1098 | 79620759 |
| Medical device site pain | 33.25 | 29.63 | 14 | 122517 | 309 | 79621548 |
| Lymphopenia | 33.11 | 29.63 | 4 | 122527 | 30553 | 79591304 |
| Adverse drug reaction | 32.93 | 29.63 | 32 | 122499 | 66360 | 79555497 |
| Premature menopause | 32.89 | 29.63 | 17 | 122514 | 605 | 79621252 |
| Fear of pregnancy | 32.88 | 29.63 | 6 | 122525 | 0 | 79621857 |
| Chlamydial cervicitis | 32.88 | 29.63 | 6 | 122525 | 0 | 79621857 |
| Inadequate lubrication | 32.88 | 29.63 | 6 | 122525 | 0 | 79621857 |
| Dysgeusia | 32.73 | 29.63 | 24 | 122507 | 57153 | 79564704 |
| Product prescribing error | 32.57 | 29.63 | 14 | 122517 | 44799 | 79577058 |
| Acute hepatic failure | 32.49 | 29.63 | 4 | 122527 | 30109 | 79591748 |
| Oral pain | 32.47 | 29.63 | 5 | 122526 | 31793 | 79590064 |
| Jaundice | 32.39 | 29.63 | 21 | 122510 | 53328 | 79568529 |
| Arrhythmia | 32.21 | 29.63 | 28 | 122503 | 61244 | 79560613 |
| High risk pregnancy | 32.11 | 29.63 | 10 | 122521 | 88 | 79621769 |
| Basal cell carcinoma | 31.76 | 29.63 | 9 | 122522 | 37366 | 79584491 |
| Limb injury | 31.66 | 29.63 | 4 | 122527 | 29524 | 79592333 |
| Emotional disorder | 31.65 | 29.63 | 69 | 122462 | 14318 | 79607539 |
| Endometrial adenocarcinoma | 31.53 | 29.63 | 20 | 122511 | 1055 | 79620802 |
| Uterine dilation and curettage | 31.49 | 29.63 | 16 | 122515 | 549 | 79621308 |
| Crying | 31.27 | 29.63 | 92 | 122439 | 22951 | 79598906 |
| Ectropion of cervix | 31.21 | 29.63 | 9 | 122522 | 59 | 79621798 |
| Throat irritation | 31.04 | 29.63 | 12 | 122519 | 40934 | 79580923 |
| Gait inability | 30.88 | 29.63 | 27 | 122504 | 58890 | 79562967 |
| Skin laceration | 30.87 | 29.63 | 4 | 122527 | 28958 | 79592899 |
| Uterine stenosis | 30.45 | 29.63 | 6 | 122525 | 3 | 79621854 |
| Uterine mass | 30.36 | 29.63 | 12 | 122519 | 224 | 79621633 |
| Neoplasm malignant | 30.30 | 29.63 | 6 | 122525 | 31804 | 79590053 |
| Adrenal insufficiency | 30.21 | 29.63 | 4 | 122527 | 28483 | 79593374 |
| Swelling face | 30.21 | 29.63 | 39 | 122492 | 71173 | 79550684 |
| Sciatica | 30.15 | 29.63 | 7 | 122524 | 33215 | 79588642 |
| Multiple sclerosis relapse | 30.09 | 29.63 | 17 | 122514 | 46516 | 79575341 |
| Pneumothorax | 29.98 | 29.63 | 4 | 122527 | 28319 | 79593538 |
| Breast mass | 29.94 | 29.63 | 44 | 122487 | 6710 | 79615147 |
| Angioedema | 29.89 | 29.63 | 44 | 122487 | 75991 | 79545866 |
| Vulvovaginal swelling | 29.88 | 29.63 | 14 | 122517 | 401 | 79621456 |
| Lactation disorder | 29.87 | 29.63 | 12 | 122519 | 234 | 79621623 |
| Ear infection | 29.80 | 29.63 | 8 | 122523 | 34424 | 79587433 |
| Disseminated intravascular coagulation | 29.78 | 29.63 | 9 | 122522 | 35833 | 79586024 |
| Affective disorder | 29.63 | 29.63 | 49 | 122482 | 8270 | 79613587 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | G03AA06 | GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE Progestogens and estrogens, fixed combinations |
| ATC | G03AA07 | GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE Progestogens and estrogens, fixed combinations |
| ATC | G03AB03 | GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE Progestogens and estrogens, sequential preparations |
| ATC | G03AC03 | GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE Progestogens |
| ATC | G03AD01 | GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE Emergency contraceptives |
| ATC | G03FA10 | GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM PROGESTOGENS AND ESTROGENS IN COMBINATION Progestogens and estrogens, fixed combinations |
| ATC | G03FA11 | GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM PROGESTOGENS AND ESTROGENS IN COMBINATION Progestogens and estrogens, fixed combinations |
| ATC | G03FB01 | GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM PROGESTOGENS AND ESTROGENS IN COMBINATION Progestogens and estrogens, sequential preparations |
| ATC | G03FB09 | GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM PROGESTOGENS AND ESTROGENS IN COMBINATION Progestogens and estrogens, sequential preparations |
| FDA CS | M0447349 | Progesterone Congeners |
| MeSH PA | D003270 | Contraceptive Agents |
| MeSH PA | D003271 | Contraceptive Agents, Female |
| MeSH PA | D000080066 | Contraceptive Agents, Hormonal |
| MeSH PA | D003278 | Contraceptives, Oral, Hormonal |
| MeSH PA | D003280 | Contraceptives, Oral, Synthetic |
| MeSH PA | D012102 | Reproductive Control Agents |
| CHEBI has role | CHEBI:49323 | contraceptive drugs |
| CHEBI has role | CHEBI:49324 | female contraceptive drugs |
| CHEBI has role | CHEBI:49326 | synthetic oral contraceptives |
| CHEBI has role | CHEBI:59826 | progestins |
| FDA EPC | N0000175602 | Progestin |
| FDA PE | N0000175830 | Inhibit Ovum Fertilization |
| FDA EPC | N0000175832 | Progestin-containing Intrauterine Device |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Contraception | indication | 13197004 | |
| Postmenopausal osteoporosis | indication | 102447009 | |
| Menopausal flushing | indication | 198436008 | |
| Dysmenorrhea | indication | 266599000 | |
| Postcoital contraception | indication | 268463003 | |
| Menorrhagia | indication | 386692008 | |
| Controlled ovarian stimulation | indication | 732970000 | |
| Female hypogonadism syndrome | off-label use | 16041008 | |
| Polycystic ovaries | off-label use | 69878008 | |
| Acne vulgaris | off-label use | 88616000 | |
| Endometriosis | off-label use | 129103003 | |
| Heart valve disorder | contraindication | 368009 | DOID:4079 |
| Hyperlipoproteinemia | contraindication | 3744001 | DOID:1168 |
| Hypocalcemia | contraindication | 5291005 | |
| Congenital heart disease | contraindication | 13213009 | |
| Hypercholesterolemia | contraindication | 13644009 | |
| Amenorrhea | contraindication | 14302001 | DOID:13938 |
| Jaundice | contraindication | 18165001 | |
| Myocardial infarction | contraindication | 22298006 | DOID:5844 |
| Puerperal endometritis | contraindication | 22399000 | |
| Diplopia | contraindication | 24982008 | |
| Retinal hemorrhage | contraindication | 28998008 | |
| Streptococcal septicemia | contraindication | 29577008 | |
| Vaginitis | contraindication | 30800001 | DOID:2170 |
| Ectopic pregnancy | contraindication | 34801009 | DOID:0060329 |
| Depressive disorder | contraindication | 35489007 | |
| Chloasma | contraindication | 36209000 | |
| Inflammation of cervix | contraindication | 37610005 | DOID:2568 |
| Migraine | contraindication | 37796009 | DOID:6364 |
| Congenital uterine anomaly | contraindication | 37849005 | |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Disorder of gallbladder | contraindication | 39621005 | DOID:0060262 |
| Hypothyroidism | contraindication | 40930008 | DOID:1459 |
| Body fluid retention | contraindication | 43498006 | |
| Thrombosis of retinal vein | contraindication | 46085004 | |
| Humoral hypercalcemia of malignancy | contraindication | 47709007 | |
| Chronic heart failure | contraindication | 48447003 | |
| Dementia | contraindication | 52448006 | |
| Hepatic porphyria | contraindication | 55056006 | DOID:3133 |
| Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
| Hyperlipidemia | contraindication | 55822004 | DOID:1168 |
| Benign mammary dysplasia | contraindication | 57993004 | |
| Obstructive hyperbilirubinemia | contraindication | 59848001 | |
| Thrombophlebitis | contraindication | 64156001 | DOID:3875 |
| Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
| Intermenstrual bleeding - irregular | contraindication | 64996003 | |
| Miscarriage with sepsis | contraindication | 67465009 | |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Cyst of ovary | contraindication | 79883001 | |
| Hyperglycemia | contraindication | 80394007 | DOID:4195 |
| Epilepsy | contraindication | 84757009 | DOID:1826 |
| Human immunodeficiency virus infection | contraindication | 86406008 | DOID:526 |
| Breast lump | contraindication | 89164003 | |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Leukemia, disease | contraindication | 93143009 | DOID:1240 |
| Malignant neoplasm of liver | contraindication | 93870000 | DOID:3571 |
| Uterine leiomyoma | contraindication | 95315005 | DOID:13223 |
| Neoplasm of endometrium | contraindication | 123844007 | DOID:1380 |
| Neoplasm of liver | contraindication | 126851005 | DOID:3571 |
| Deep venous thrombosis | contraindication | 128053003 | |
| Seizure disorder | contraindication | 128613002 | |
| Bed-ridden | contraindication | 160685001 | |
| Liver function tests abnormal | contraindication | 166603001 | |
| Mammography abnormal | contraindication | 168750009 | |
| Angina pectoris | contraindication | 194828000 | |
| Asthma | contraindication | 195967001 | DOID:2841 |
| Cerebrovascular accident | contraindication | 230690007 | |
| Pulmonary thromboembolism | contraindication | 233935004 | |
| Thrombophilia | contraindication | 234467004 | DOID:2452 |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Cholestasis of pregnancy | contraindication | 235888006 | |
| Uterine perforation by intrauterine contraceptive device | contraindication | 236738001 | |
| Endometrial carcinoma | contraindication | 254878006 | DOID:2871 |
| Chorea | contraindication | 271700006 | |
| Anemia | contraindication | 271737000 | DOID:2355 |
| Pregnancy, function | contraindication | 289908002 | |
| Hypertriglyceridemia | contraindication | 302870006 | |
| Abnormal uterine bleeding unrelated to menstrual cycle | contraindication | 312984006 | |
| Functional visual loss | contraindication | 313165001 | |
| Malignant tumor of cervix | contraindication | 363354003 | DOID:4362 |
| Malignant tumor of ovary | contraindication | 363443007 | DOID:2394 |
| Thromboembolic disorder | contraindication | 371039008 | |
| Cardiovascular event risk | contraindication | 395112001 | |
| Disorder of coronary artery | contraindication | 414024009 | |
| Obesity | contraindication | 414916001 | DOID:9970 |
| Estrogen receptor positive tumor | contraindication | 416053008 | |
| Porphyria | contraindication | 418470004 | |
| Bacterial vaginosis | contraindication | 419760006 | DOID:3385 |
| Optic disc edema | contraindication | 423341008 | DOID:146 |
| Family history of malignant neoplasm of breast | contraindication | 429740004 | |
| Hypertensive urgency | contraindication | 443482000 | |
| Carcinoma of female breast | contraindication | 447782002 | |
| Smokes tobacco daily | contraindication | 449868002 | |
| Severe Headache Disorder | contraindication | ||
| Nonspecific Abnormal Papanicolaou Smear of Cervix | contraindication | ||
| Uterine Scarring | contraindication | ||
| Major Surgery with Prolonged Post-Operative Immobilization | contraindication | ||
| Intrauterine Device Insertion with Acute Vaginitis | contraindication | ||
| Inflammatory Disease of Female Pelvic Organs | contraindication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
|---|---|---|---|---|---|---|---|---|---|---|
| 0.03MG,0.01MG;0.15MG,N/A | SEASONIQUE | TEVA BRANDED PHARM | N021840 | May 25, 2006 | RX | TABLET | ORAL | 7615545 | June 15, 2023 | PREVENTION OF PREGNANCY |
| 0.02MG,0.1MG;0.01MG,N/A | LOSEASONIQUE | TEVA BRANDED PHARM | N022262 | Oct. 24, 2008 | RX | TABLET | ORAL | 7615545 | June 15, 2023 | PREVENTION OF PREGNANCY |
| 0.03MG,0.01MG;0.15MG,N/A | SEASONIQUE | TEVA BRANDED PHARM | N021840 | May 25, 2006 | RX | TABLET | ORAL | 7320969 | Jan. 30, 2024 | PREVENTION OF PREGNANCY IN WOMEN WHO ELECT TO USE ORAL CONTRACEPTIVES AS A METHOD OF CONTRACEPTION |
| 0.02MG,0.15MG;0.025MG,0.15MG;0.03MG,0.15MG;0.01MG,N/A | QUARTETTE | TEVA BRANDED PHARM | N204061 | March 28, 2013 | RX | TABLET | ORAL | 8450299 | Oct. 7, 2025 | PREVENTION OF PREGNANCY |
| 0.02MG;0.1MG | BALCOLTRA | AVION PHARMS | N208612 | Jan. 9, 2018 | RX | TABLET | ORAL | 7838042 | June 1, 2027 | ADMINISTRATION OF FERROUS BISGLYCINATE TABLETS |
| 0.03MG,0.01MG;0.15MG,N/A | SEASONIQUE | TEVA BRANDED PHARM | N021840 | May 25, 2006 | RX | TABLET | ORAL | 7855190 | Dec. 5, 2028 | PREVENTION OF PREGNANCY |
| 0.02MG,0.1MG;0.01MG,N/A | LOSEASONIQUE | TEVA BRANDED PHARM | N022262 | Oct. 24, 2008 | RX | TABLET | ORAL | 7855190 | Dec. 5, 2028 | PREVENTION OF PREGNANCY |
| 52MG | MIRENA | BAYER HLTHCARE | N021225 | Dec. 6, 2000 | RX | INTRAUTERINE DEVICE | INTRAUTERINE | 10561524 | Sept. 16, 2029 | A METHOD OF POSITIONING AN INTRAUTERINE SYSTEM (IUS) BY DETERMINING A DEPTH OF THE UTERUS, HOLDING AN INSERTER HANDLE WITH ONE HAND, INSERTING THE IUS INTO THE UTERUS, AND RETRACTING A SLIDER ON THE HANDLE TO RELEASE THE IUS INTO THE UTERUS |
| 52MG | MIRENA | BAYER HLTHCARE | N021225 | Dec. 6, 2000 | RX | INTRAUTERINE DEVICE | INTRAUTERINE | 9615965 | Sept. 16, 2029 | A METHOD OF POSITIONING AN INTRAUTERINE SYSTEM BY HOLDING AN INSERTER HANDLE WITH ONE HAND, ADVANCING THE INSERTER THROUGH THE CERVIX AND INTO THE UTERUS, AND RETRACTING A SLIDER ON THE HANDLE TO RELEASE THE INTRAUTERINE SYSTEM |
| 13.5MG | SKYLA | BAYER HLTHCARE | N203159 | Jan. 9, 2013 | RX | INTRAUTERINE DEVICE | INTRAUTERINE | 10561524 | Sept. 16, 2029 | A METHOD OF POSITIONING AN INTRAUTERINE SYSTEM (IUS) BY DETERMINING A DEPTH OF THE UTERUS, HOLDING AN INSERTER HANDLE WITH ONE HAND, INSERTING THE IUS INTO THE UTERUS, AND RETRACTING A SLIDER ON THE HANDLE TO RELEASE THE IUS INTO THE UTERUS |
| 13.5MG | SKYLA | BAYER HLTHCARE | N203159 | Jan. 9, 2013 | RX | INTRAUTERINE DEVICE | INTRAUTERINE | 9615965 | Sept. 16, 2029 | A METHOD OF POSITIONING AN INTRAUTERINE SYSTEM BY HOLDING AN INSERTER HANDLE WITH ONE HAND, ADVANCING THE INSERTER THROUGH THE CERVIX AND INTO THE UTERUS, AND RETRACTING A SLIDER ON THE HANDLE TO RELEASE THE INTRAUTERINE SYSTEM |
| 19.5MG | KYLEENA | BAYER HLTHCARE | N208224 | Sept. 16, 2016 | RX | INTRAUTERINE DEVICE | INTRAUTERINE | 10561524 | Sept. 16, 2029 | A METHOD OF POSITIONING AN INTRAUTERINE SYSTEM (IUS) BY DETERMINING A DEPTH OF THE UTERUS, HOLDING AN INSERTER HANDLE WITH ONE HAND, INSERTING THE IUS INTO THE UTERUS, AND RETRACTING A SLIDER ON THE HANDLE TO RELEASE THE IUS INTO THE UTERUS |
| 19.5MG | KYLEENA | BAYER HLTHCARE | N208224 | Sept. 16, 2016 | RX | INTRAUTERINE DEVICE | INTRAUTERINE | 9615965 | Sept. 16, 2029 | A METHOD OF POSITIONING AN INTRAUTERINE SYSTEM BY HOLDING AN INSERTER HANDLE WITH ONE HAND, ADVANCING THE INSERTER THROUGH THE CERVIX AND INTO THE UTERUS, AND RETRACTING A SLIDER ON THE HANDLE TO RELEASE THE INTRAUTERINE SYSTEM |
| 52MG | LILETTA | MEDICINES360 | N206229 | Feb. 26, 2015 | RX | INTRAUTERINE DEVICE | INTRAUTERINE | 11090186 | Oct. 24, 2033 | A METHOD FOR PREVENTION OF PREGNANCY |
| 52MG | LILETTA | MEDICINES360 | N206229 | Feb. 26, 2015 | RX | INTRAUTERINE DEVICE | INTRAUTERINE | 10028858 | March 22, 2034 | A METHOD FOR PREVENTION OF PREGNANCY |
Orange Book exclusivity data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
|---|---|---|---|---|---|---|---|---|---|
| 0.03MG/24HR;0.12MG/24HR | TWIRLA | AGILE | N204017 | Feb. 14, 2020 | RX | SYSTEM | TRANSDERMAL | Feb. 14, 2023 | NEW PRODUCT |
| 0.02MG;0.1MG | TYBLUME | EXELTIS USA INC | N209405 | March 30, 2020 | RX | TABLET | ORAL | March 30, 2023 | NEW DOSAGE FORM |
| 52MG | MIRENA | BAYER HLTHCARE | N021225 | Dec. 6, 2000 | RX | INTRAUTERINE DEVICE | INTRAUTERINE | Aug. 20, 2023 | DOSING REGIMEN EXTENDING THE CONTRACEPTION USE FROM 5 YEARS TO UP TO 6 YEARS |
| 52MG | LILETTA | MEDICINES360 | N206229 | Feb. 26, 2015 | RX | INTRAUTERINE DEVICE | INTRAUTERINE | June 29, 2026 | TREATMENT OF HEAVY MENSTRUAL BLEEDING FOR UP TO 5 YEARS IN PATIENTS WHO CHOOSE INTRAUTERINE CONTRACEPTION AS THEIR METHOD OF CONTRACEPTION |
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Progesterone receptor | Nuclear hormone receptor | AGONIST | ED50 | 12.80 | WOMBAT-PK | CHEMBL | |||
| Glucocorticoid receptor | Nuclear hormone receptor | Ki | 7.17 | DRUG MATRIX | |||||
| Estrogen receptor | Nuclear hormone receptor | WOMBAT-PK | |||||||
| Sodium-dependent serotonin transporter | Transporter | Ki | 6.23 | DRUG MATRIX | |||||
| Sex hormone-binding globulin | Secreted | Kd | 8.91 | CHEMBL | |||||
| Androgen receptor | Transcription factor | Ki | 8.37 | DRUG MATRIX | |||||
| Progesterone receptor | Transcription factor | Ki | 9.34 | DRUG MATRIX |
External reference:
| ID | Source |
|---|---|
| 4018027 | VUID |
| N0000146370 | NUI |
| D00950 | KEGG_DRUG |
| 6533-00-2 | SECONDARY_CAS_RN |
| 4018023 | VANDF |
| 4018027 | VANDF |
| C0023566 | UMLSCUI |
| CHEBI:6443 | CHEBI |
| NOG | PDB_CHEM_ID |
| CHEMBL1389 | ChEMBL_ID |
| CHEMBL2107797 | ChEMBL_ID |
| DB00367 | DRUGBANK_ID |
| D016912 | MESH_DESCRIPTOR_UI |
| 13109 | PUBCHEM_CID |
| 2881 | IUPHAR_LIGAND_ID |
| 3475 | INN_ID |
| 5W7SIA7YZW | UNII |
| DB09389 | DRUGBANK_ID |
| 6373 | RXNORM |
| 180470 | MMSL |
| 4974 | MMSL |
| 5191 | MMSL |
| d00557 | MMSL |
| d03034 | MMSL |
| 001303 | NDDF |
| 001304 | NDDF |
| 001325 | NDDF |
| 109032009 | SNOMEDCT_US |
| 126106007 | SNOMEDCT_US |
| 126109000 | SNOMEDCT_US |
| 82240008 | SNOMEDCT_US |
| D009644 | MESH_DESCRIPTOR_UI |
| 2157 | INN_ID |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| LILETTA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-5858 | INTRAUTERINE DEVICE | 52 mg | INTRAUTERINE | NDA | 31 sections |
| LILETTA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-5858 | INTRAUTERINE DEVICE | 52 mg | INTRAUTERINE | NDA | 31 sections |
| LILETTA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-5858 | INTRAUTERINE DEVICE | 52 mg | INTRAUTERINE | NDA | 31 sections |
| Option 2 | HUMAN OTC DRUG LABEL | 1 | 0113-2003 | TABLET | 1.50 mg | ORAL | ANDA | 14 sections |
| Amethyst | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0480-3472 | TABLET | 90 ug | ORAL | ANDA | 24 sections |
| Amethyst | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0480-3472 | TABLET | 90 ug | ORAL | ANDA | 24 sections |
| Levonorgestrel | HUMAN OTC DRUG LABEL | 1 | 0536-1142 | TABLET | 1.50 mg | ORAL | ANDA | 14 sections |
| Emergency Contraceptive | HUMAN OTC DRUG LABEL | 1 | 0536-1391 | TABLET | 1.50 mg | ORAL | ANDA | 13 sections |
| Levonorgestrel and Ethinyl Estradiol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0591-0295 | TABLET | 90 ug | ORAL | ANDA | 24 sections |
| New Day | HUMAN OTC DRUG LABEL | 1 | 16714-809 | TABLET | 1.50 mg | ORAL | ANDA | 12 sections |
| NEXT CHOICE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-443 | TABLET | 0.75 mg | ORAL | ANDA | 14 sections |
| Plan B One-Step | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-973 | TABLET | 1.50 mg | ORAL | NDA | 25 sections |
| Levonorgestrel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 40032-620 | TABLET | 1.50 mg | ORAL | ANDA | 24 sections |
| Levonorgestrel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 40032-622 | TABLET | 1.50 mg | ORAL | ANDA | 8 sections |
| My Way | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43386-620 | TABLET | 1.50 mg | ORAL | ANDA | 24 sections |
| My Way | HUMAN OTC DRUG LABEL | 1 | 43386-622 | TABLET | 1.50 mg | ORAL | ANDA | 12 sections |
| Levonorgestrel | HUMAN OTC DRUG LABEL | 1 | 49615-017 | TABLET | 1.50 mg | ORAL | ANDA | 13 sections |
| Plan B One-Step | HUMAN OTC DRUG LABEL | 1 | 50090-1141 | TABLET | 1.50 mg | ORAL | NDA | 14 sections |
| Plan B One-Step | HUMAN OTC DRUG LABEL | 1 | 50090-3830 | TABLET | 1.50 mg | ORAL | NDA | 15 sections |
| Plan B One-Step | HUMAN OTC DRUG LABEL | 1 | 50090-5978 | TABLET | 1.50 mg | ORAL | NDA | 15 sections |
| EContra EZ | HUMAN OTC DRUG LABEL | 1 | 50102-111 | TABLET | 1.50 mg | ORAL | ANDA | 9 sections |
| EContra One-Step | Human OTC Drug Label | 1 | 50102-211 | TABLET | 1.50 mg | ORAL | ANDA | 14 sections |
| EContra One-Step | Human OTC Drug Label | 1 | 50102-211 | TABLET | 1.50 mg | ORAL | ANDA | 14 sections |
| Skyla | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50419-422 | INTRAUTERINE DEVICE | 13.50 mg | INTRAUTERINE | NDA | 29 sections |
| Skyla | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50419-422 | INTRAUTERINE DEVICE | 13.50 mg | INTRAUTERINE | NDA | 29 sections |
| Skyla | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50419-422 | INTRAUTERINE DEVICE | 13.50 mg | INTRAUTERINE | NDA | 29 sections |
| Mirena | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50419-423 | INTRAUTERINE DEVICE | 52 mg | INTRAUTERINE | NDA | 29 sections |
| Mirena | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50419-423 | INTRAUTERINE DEVICE | 52 mg | INTRAUTERINE | NDA | 29 sections |
| Kyleena | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50419-424 | INTRAUTERINE DEVICE | 19.50 mg | INTRAUTERINE | NDA | 29 sections |
| Kyleena | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50419-424 | INTRAUTERINE DEVICE | 19.50 mg | INTRAUTERINE | NDA | 29 sections |