levodopa Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
dopamine receptor agonists, dopamine derivatives, used as antiparkinsonism/prolactin inhibitors 1567 59-92-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • levodopa
  • ledopa
  • 3-Hydroxy-L-tyrosine
  • DOPA
  • dihydroxyphenylalanine
The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to DOPAMINE. It is used for the treatment of PARKINSONIAN DISORDERS and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system.
  • Molecular weight: 197.19
  • Formula: C9H11NO4
  • CLOGP: -2.82
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 4
  • TPSA: 103.78
  • ALOGS: -1.78
  • ROTB: 3

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
3.50 g O
0.60 g O
0.45 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1.65 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 674.47 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 41 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.70 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 23 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.76 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.30 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Sept. 19, 2019 EMA Acorda Therapeutics Ireland Limited
June 4, 1970 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Dyskinesia 1869.51 12.13 826 52652 28099 46604485
On and off phenomenon 1506.31 12.13 368 53110 1623 46630961
Hallucination 1498.61 12.13 847 52631 49104 46583480
Stoma site discharge 1328.43 12.13 331 53147 1609 46630975
Freezing phenomenon 966.27 12.13 243 53235 1234 46631350
Stoma site erythema 779.15 12.13 195 53283 967 46631617
Fall 722.18 12.13 1322 52156 327775 46304809
Hyperkinesia 702.36 12.13 197 53281 1615 46630969
Stoma site pain 643.86 12.13 165 53313 915 46631669
Device dislocation 634.64 12.13 363 53115 21439 46611145
Stoma site infection 525.25 12.13 133 53345 697 46631887
Hallucination, visual 513.20 12.13 295 53183 17578 46615006
Bradykinesia 465.12 12.13 174 53304 3792 46628792
Muscle rigidity 454.71 12.13 224 53254 9737 46622847
General physical health deterioration 426.77 12.13 591 52887 115178 46517406
Tremor 397.55 12.13 571 52907 115068 46517516
Akinesia 390.22 12.13 125 53353 1676 46630908
Stoma site hypergranulation 387.05 12.13 94 53384 401 46632183
Device occlusion 348.96 12.13 159 53319 5786 46626798
Stoma site inflammation 348.31 12.13 90 53388 518 46632066
Delusion 321.99 12.13 185 53293 11003 46621581
Confusional state 314.86 12.13 615 52863 159277 46473307
Gait disturbance 276.53 12.13 551 52927 144712 46487872
Stoma site extravasation 268.51 12.13 67 53411 327 46632257
Dystonia 263.63 12.13 163 53315 11094 46621490
Device issue 254.56 12.13 199 53279 19781 46612803
Dopamine dysregulation syndrome 239.44 12.13 57 53421 219 46632365
Stoma site irritation 233.05 12.13 56 53422 226 46632358
Parkinson's disease 227.03 12.13 80 53398 1459 46631125
Parkinsonism 211.68 12.13 125 53353 7823 46624761
Dysphagia 210.61 12.13 343 53135 76969 46555615
Rheumatoid arthritis 208.70 12.13 18 53460 240197 46392387
Dementia 199.54 12.13 153 53325 14777 46617807
Stoma site reaction 198.23 12.13 50 53428 257 46632327
Mobility decreased 185.98 12.13 284 53194 60310 46572274
Therapeutic response shortened 185.31 12.13 99 53379 5100 46627484
Impulse-control disorder 178.07 12.13 55 53423 649 46631935
Fibroma 174.99 12.13 58 53420 871 46631713
Device connection issue 171.70 12.13 53 53425 624 46631960
Delirium 170.90 12.13 212 53266 37016 46595568
Orthostatic hypotension 168.98 12.13 173 53305 24485 46608099
Cognitive disorder 162.87 12.13 206 53272 36677 46595907
Rash 161.63 12.13 105 53373 356407 46276177
Device kink 160.80 12.13 66 53412 1852 46630732
Pneumoperitoneum 152.86 12.13 59 53419 1403 46631181
Therapeutic product effect variable 151.03 12.13 54 53424 1029 46631555
Headache 141.52 12.13 206 53272 478146 46154438
Hypophagia 139.52 12.13 170 53308 29136 46603448
Psychotic disorder 139.45 12.13 150 53328 22471 46610113
Stoma site haemorrhage 137.08 12.13 49 53429 933 46631651
Hypokinesia 136.09 12.13 109 53369 11213 46621371
Somnolence 132.25 12.13 437 53041 156084 46476500
Parkinsonism hyperpyrexia syndrome 130.91 12.13 32 53446 141 46632443
Stoma site odour 127.64 12.13 27 53451 50 46632534
Hip fracture 126.33 12.13 154 53324 26402 46606182
Speech disorder 120.18 12.13 176 53302 35991 46596593
Compulsive shopping 119.84 12.13 42 53436 753 46631831
Reduced facial expression 119.64 12.13 47 53431 1173 46631411
Drug hypersensitivity 118.51 12.13 66 53412 243759 46388825
Pneumonia aspiration 115.60 12.13 161 53317 31444 46601140
Neuroleptic malignant syndrome 114.75 12.13 98 53380 11024 46621560
Arthralgia 114.72 12.13 150 53328 364453 46268131
Diarrhoea 113.57 12.13 301 53177 559301 46073283
Abnormal dreams 113.11 12.13 94 53384 10185 46622399
Restlessness 111.77 12.13 142 53336 25382 46607202
Abnormal behaviour 109.85 12.13 128 53350 20930 46611654
Underdose 102.21 12.13 119 53359 19439 46613145
Disorientation 98.00 12.13 162 53316 36756 46595828
Infusion related reaction 95.33 12.13 5 53473 101203 46531381
Sinusitis 94.95 12.13 17 53461 129751 46502833
Alopecia 94.47 12.13 34 53444 162380 46470204
Device alarm issue 93.79 12.13 41 53437 1349 46631235
Sudden onset of sleep 93.02 12.13 33 53445 614 46631970
Joint swelling 92.87 12.13 37 53441 166036 46466548
Embedded device 91.38 12.13 51 53427 2865 46629719
Prescribed underdose 90.71 12.13 89 53389 11964 46620620
Balance disorder 89.75 12.13 216 53262 64305 46568279
Jealous delusion 89.63 12.13 20 53458 53 46632531
Femoral neck fracture 86.88 12.13 73 53405 8030 46624554
Pruritus 86.56 12.13 90 53388 242262 46390322
Pleurothotonus 83.97 12.13 36 53442 1129 46631455
Incorrect route of product administration 82.81 12.13 98 53380 16285 46616299
Nocturia 82.19 12.13 67 53411 7065 46625519
Stereotypy 81.67 12.13 27 53451 402 46632182
Death 80.82 12.13 658 52820 334890 46297694
Febrile neutropenia 79.64 12.13 8 53470 94619 46537965
Vitamin B6 deficiency 79.00 12.13 19 53459 77 46632507
Aggression 78.92 12.13 113 53365 22631 46609953
Fluid intake reduced 76.91 12.13 48 53430 3318 46629266
Agitation 76.51 12.13 185 53293 55230 46577354
Completed suicide 76.04 12.13 36 53442 145884 46486700
Dropped head syndrome 74.48 12.13 19 53459 103 46632481
Neutropenia 73.59 12.13 36 53442 143168 46489416
Toxicity to various agents 72.97 12.13 81 53397 211685 46420899
Choking 72.84 12.13 67 53411 8309 46624275
Injection site pain 72.24 12.13 17 53461 107135 46525449
Weight decreased 71.96 12.13 450 53028 210399 46422185
Maternal exposure during pregnancy 71.70 12.13 15 53463 102534 46530050
Nasopharyngitis 71.47 12.13 44 53434 153954 46478630
Urticaria 71.45 12.13 23 53455 117869 46514715
Posture abnormal 70.53 12.13 39 53439 2151 46630433
Gambling disorder 67.75 12.13 32 53446 1264 46631320
Swelling 67.55 12.13 29 53449 124482 46508102
Stoma site discomfort 66.98 12.13 17 53461 90 46632494
Psychomotor hyperactivity 66.84 12.13 68 53410 9545 46623039
Stoma complication 66.77 12.13 20 53458 211 46632373
Nonspecific reaction 65.28 12.13 35 53443 1815 46630769
Orthostatic intolerance 64.99 12.13 30 53448 1124 46631460
Exposure during pregnancy 64.02 12.13 22 53456 108190 46524394
Torticollis 63.96 12.13 34 53444 1733 46630851
Decubitus ulcer 63.40 12.13 67 53411 9831 46622753
Treatment failure 62.29 12.13 15 53463 93072 46539512
Bezoar 62.03 12.13 31 53447 1388 46631196
Thrombocytopenia 61.80 12.13 34 53444 126547 46506037
Contraindicated product administered 61.76 12.13 9 53469 79938 46552646
Cough 61.36 12.13 106 53372 230143 46402441
Wrong technique in device usage process 60.77 12.13 34 53444 1919 46630665
Acute kidney injury 58.90 12.13 113 53365 235742 46396842
Dyspnoea 58.00 12.13 350 53128 515198 46117386
Anxiety 55.72 12.13 378 53100 181579 46451005
Gait inability 55.68 12.13 124 53354 35079 46597505
Tension 55.61 12.13 37 53441 2855 46629729
Parkinsonian gait 55.18 12.13 21 53457 480 46632104
Hypersensitivity 54.55 12.13 55 53423 150266 46482318
Pancytopenia 54.43 12.13 15 53463 85043 46547541
Stoma site cellulitis 54.28 12.13 12 53466 30 46632554
Urinary tract infection 54.02 12.13 434 53044 219832 46412752
Nightmare 54.00 12.13 80 53398 16518 46616066
Asthma 53.47 12.13 19 53459 91523 46541061
Dysstasia 53.00 12.13 82 53396 17586 46614998
Intentional medical device removal by patient 52.71 12.13 17 53461 233 46632351
Platelet count decreased 51.59 12.13 25 53453 99999 46532585
Stoma site abscess 51.34 12.13 14 53464 102 46632482
Device colour issue 51.12 12.13 11 53467 23 46632561
Pain 50.92 12.13 329 53149 476619 46155965
Parkinsonian crisis 50.80 12.13 11 53467 24 46632560
Drug dispensed to wrong patient 50.04 12.13 16 53462 213 46632371
Excessive granulation tissue 50.02 12.13 23 53455 854 46631730
Memory impairment 49.14 12.13 197 53281 77140 46555444
Hallucination, auditory 48.92 12.13 61 53417 10695 46621889
Device leakage 48.77 12.13 44 53434 5321 46627263
Paranoia 48.04 12.13 60 53418 10537 46622047
Chest pain 48.03 12.13 80 53398 176244 46456340
Motor dysfunction 47.90 12.13 50 53428 7232 46625352
Hypersexuality 47.89 12.13 19 53459 487 46632097
Drug intolerance 47.66 12.13 59 53419 146990 46485594
Off label use 47.45 12.13 249 53229 379592 46252992
Bedridden 46.63 12.13 55 53423 9104 46623480
Camptocormia 46.62 12.13 15 53463 204 46632380
Movement disorder 46.13 12.13 75 53403 16774 46615810
Stoma site oedema 45.73 12.13 9 53469 9 46632575
Stoma site induration 45.73 12.13 9 53469 9 46632575
Deep brain stimulation 45.73 12.13 9 53469 9 46632575
Depressed mood 45.72 12.13 111 53367 33208 46599376
Psoriasis 44.75 12.13 17 53461 78587 46553997
Initial insomnia 43.43 12.13 38 53440 4414 46628170
Hepatic enzyme increased 42.85 12.13 20 53458 81767 46550817
Injection site erythema 42.53 12.13 16 53462 74411 46558173
White blood cell count decreased 41.93 12.13 40 53438 112191 46520393
Terminal state 41.33 12.13 28 53450 2226 46630358
Apathy 40.97 12.13 46 53432 7222 46625362
Back pain 40.85 12.13 115 53363 209924 46422660
Malignant neoplasm progression 40.52 12.13 12 53466 64914 46567670
Pemphigus 40.33 12.13 3 53475 45271 46587313
Stoma site candida 39.77 12.13 9 53469 26 46632558
Oromandibular dystonia 39.62 12.13 16 53462 430 46632154
Musculoskeletal stiffness 39.06 12.13 218 53260 97775 46534809
Product availability issue 38.90 12.13 21 53457 1104 46631480
Stomatitis 38.50 12.13 15 53463 68282 46564302
Ileus 37.69 12.13 62 53416 14002 46618582
Loss of consciousness 37.46 12.13 232 53246 108006 46524578
Compulsive hoarding 36.53 12.13 10 53468 74 46632510
Dementia with Lewy bodies 36.24 12.13 13 53465 250 46632334
Device loosening 36.22 12.13 14 53464 334 46632250
Abortion spontaneous 35.91 12.13 4 53474 43642 46588942
Therapeutic product effect delayed 35.62 12.13 24 53454 1891 46630693
Altered state of consciousness 35.53 12.13 81 53397 23267 46609317
Unintentional medical device removal 34.97 12.13 34 53444 4519 46628065
Prescribed overdose 34.91 12.13 51 53427 10398 46622186
Multiple system atrophy 34.88 12.13 12 53466 203 46632381
Drooling 34.58 12.13 29 53449 3180 46629404
Myalgia 34.29 12.13 55 53423 123033 46509551
Erythema 34.26 12.13 70 53408 142750 46489834
Glossodynia 34.25 12.13 5 53473 44368 46588216
Medical device site pain 34.14 12.13 12 53466 217 46632367
Apraxia 33.59 12.13 22 53456 1653 46630931
Restless legs syndrome 33.58 12.13 63 53415 15780 46616804
Herpes zoster 33.44 12.13 18 53460 67854 46564730
Sleep talking 33.30 12.13 18 53460 949 46631635
Oropharyngeal pain 33.27 12.13 22 53456 74146 46558438
Fracture 33.06 12.13 64 53414 16407 46616177
Aspiration 32.54 12.13 47 53431 9484 46623100
Acute psychosis 32.43 12.13 23 53455 1969 46630615
Injection site swelling 32.42 12.13 4 53474 40323 46592261
Vitamin B12 decreased 31.83 12.13 26 53452 2749 46629835
Injection site pruritus 31.81 12.13 4 53474 39739 46592845
Psychotic symptom 31.50 12.13 17 53461 893 46631691
Epilepsy 31.41 12.13 78 53400 23660 46608924
Anaphylactic reaction 31.05 12.13 11 53467 53101 46579483
Syncope 31.01 12.13 216 53262 104587 46527997
Psoriatic arthropathy 30.79 12.13 3 53475 36376 46596208
Polyneuropathy 30.75 12.13 51 53427 11593 46620991
Device breakage 30.50 12.13 46 53432 9646 46622938
Stoma site hypersensitivity 30.49 12.13 6 53472 6 46632578
Cerebral atrophy 30.34 12.13 32 53446 4684 46627900
Abdominal discomfort 29.94 12.13 82 53396 151083 46481501
Product prescribing error 29.90 12.13 69 53409 19978 46612606
Euthanasia 29.80 12.13 7 53471 25 46632559
Pelvic fracture 29.75 12.13 50 53428 11489 46621095
Upper respiratory tract infection 29.68 12.13 18 53460 63538 46569046
Product administration error 29.64 12.13 68 53410 19613 46612971
Injection site reaction 29.57 12.13 9 53469 47840 46584744
Illusion 29.14 12.13 17 53461 1039 46631545
Medical device change 29.03 12.13 12 53466 343 46632241
Device physical property issue 28.98 12.13 19 53459 1430 46631154
Migraine 28.51 12.13 23 53455 70003 46562581
Pyrexia 28.46 12.13 259 53219 348543 46284041
Suspiciousness 28.45 12.13 12 53466 361 46632223
Injection site bruising 27.54 12.13 4 53474 35632 46596952
Enteral nutrition 27.43 12.13 7 53471 38 46632546
Arthropathy 27.41 12.13 34 53444 84666 46547918
Resting tremor 27.23 12.13 14 53464 666 46631918
Fatigue 27.15 12.13 513 52965 608184 46024400
Neutrophil count decreased 27.14 12.13 8 53470 43418 46589166
Helplessness 27.02 12.13 10 53468 211 46632373
Depressed level of consciousness 26.93 12.13 117 53361 47452 46585132
Extra dose administered 26.89 12.13 30 53448 4677 46627907
Femur fracture 26.56 12.13 98 53380 36899 46595685
Gastrostomy 26.43 12.13 13 53465 562 46632022
Nasal congestion 26.40 12.13 11 53467 48102 46584482
Hallucinations, mixed 26.34 12.13 27 53451 3822 46628762
Catecholamines urine increased 26.34 12.13 6 53472 18 46632566
Aphasia 26.07 12.13 82 53396 28485 46604099
Device placement issue 25.77 12.13 11 53467 341 46632243
Drug interaction 25.72 12.13 350 53128 202744 46429840
Hyperventilation 25.64 12.13 32 53446 5615 46626969
Anaemia 25.42 12.13 180 53298 255599 46376985
Medical device site ulcer 25.41 12.13 5 53473 5 46632579
Stoma site rash 25.41 12.13 5 53473 5 46632579
Medical device site injury 25.41 12.13 5 53473 5 46632579
Gastrointestinal complication associated with device 25.41 12.13 5 53473 5 46632579
Lymphadenopathy 25.33 12.13 4 53474 33484 46599100
Peritonitis 25.26 12.13 66 53412 20648 46611936
Abnormal faeces 25.20 12.13 27 53451 4022 46628562
Alanine aminotransferase increased 25.12 12.13 39 53439 88412 46544172
Intussusception 25.10 12.13 12 53466 487 46632097
Epistaxis 25.10 12.13 22 53456 64283 46568301
Wrong technique in product usage process 25.04 12.13 126 53352 54296 46578288
Liver function test abnormal 24.92 12.13 11 53467 46476 46586108
Middle insomnia 24.23 12.13 41 53437 9474 46623110
Interstitial lung disease 24.20 12.13 16 53462 53933 46578651
Medical device site hyperaesthesia 24.10 12.13 5 53473 8 46632576
Salivary hypersecretion 23.80 12.13 33 53445 6412 46626172
Radioisotope scan abnormal 23.76 12.13 9 53469 203 46632381
Head injury 23.68 12.13 72 53406 24564 46608020
Chest discomfort 23.60 12.13 42 53436 90227 46542357
COVID-19 23.49 12.13 60 53418 18515 46614069
Feeding disorder 23.45 12.13 42 53436 10152 46622432
Decreased appetite 23.31 12.13 331 53147 193505 46439079
Poor quality sleep 23.30 12.13 53 53425 15200 46617384
Faecaloma 23.28 12.13 36 53442 7716 46624868
Heart rate increased 23.19 12.13 31 53447 74760 46557824
Bradyphrenia 23.16 12.13 32 53446 6198 46626386
Disturbance in attention 22.99 12.13 84 53394 31476 46601108
Mental disorder 22.94 12.13 67 53411 22358 46610226
General physical condition abnormal 22.80 12.13 24 53454 3504 46629080
Oedema 22.68 12.13 26 53452 67045 46565539
Wheezing 22.41 12.13 17 53461 53369 46579215
Hand deformity 22.29 12.13 6 53472 34568 46598016
Bone pain 22.28 12.13 13 53465 46877 46585707
Rapid eye movement sleep behaviour disorder 22.15 12.13 8 53470 157 46632427
Bronchitis 22.11 12.13 56 53422 105923 46526661
Behaviour disorder 21.71 12.13 18 53460 1943 46630641
Plasma cell myeloma 21.61 12.13 12 53466 44466 46588118
Rhinorrhoea 21.56 12.13 14 53464 47651 46584933
Medical device site erosion 21.48 12.13 5 53473 17 46632567
Lower respiratory tract infection 21.32 12.13 19 53459 55070 46577514
Emotional disorder 21.29 12.13 45 53433 12279 46620305
Sopor 21.01 12.13 60 53418 19768 46612816
Eczema eyelids 21.00 12.13 7 53471 107 46632477
Clavicle fracture 20.87 12.13 21 53457 2908 46629676
Therapeutic product effect incomplete 20.76 12.13 157 53321 77996 46554588
Vascular encephalopathy 20.69 12.13 10 53468 416 46632168
Chorea 20.52 12.13 14 53464 1126 46631458
Nausea 20.47 12.13 616 52862 686838 45945746
Extrapyramidal disorder 20.47 12.13 42 53436 11226 46621358
Medical device site dryness 20.32 12.13 4 53474 4 46632580
Osteonecrosis of jaw 20.32 12.13 7 53471 34395 46598189
Hypertension 20.07 12.13 137 53341 196219 46436365
Cachexia 19.90 12.13 26 53452 4773 46627811
Product use issue 19.75 12.13 50 53428 94594 46537990
Breast cancer 19.75 12.13 14 53464 45504 46587080
Swelling face 19.70 12.13 19 53459 53040 46579544
Mucosal inflammation 19.70 12.13 10 53468 38966 46593618
Hallucination, tactile 19.54 12.13 8 53470 223 46632361
Leukopenia 19.53 12.13 30 53448 68313 46564271
Vaginal haemorrhage 19.50 12.13 3 53475 25601 46606983
Arthritis 19.30 12.13 37 53441 77279 46555305
Obsessive-compulsive disorder 19.24 12.13 21 53457 3194 46629390
Limbic encephalitis 19.24 12.13 8 53470 232 46632352
Eating disorder 19.23 12.13 48 53430 14606 46617978
Upper limb fracture 19.09 12.13 50 53428 15663 46616921
Impulsive behaviour 19.09 12.13 15 53463 1500 46631084
Diet refusal 19.07 12.13 11 53467 658 46631926
Intentional overdose 19.05 12.13 28 53450 64916 46567668
Fibromyalgia 18.96 12.13 9 53469 36454 46596130
Faeces hard 18.76 12.13 14 53464 1297 46631287
Influenza like illness 18.74 12.13 23 53455 57547 46575037
Wheelchair user 18.66 12.13 23 53455 3985 46628599
Dyschezia 18.63 12.13 15 53463 1553 46631031
Disease progression 18.46 12.13 49 53429 91251 46541333
Neoplasm progression 18.44 12.13 4 53474 26679 46605905
Weight increased 18.21 12.13 112 53366 164361 46468223
Incontinence 18.20 12.13 37 53441 9825 46622759
Viral infection 18.12 12.13 6 53472 30229 46602355
Gastrostomy tube site complication 18.09 12.13 4 53474 10 46632574
Granuloma 18.01 12.13 22 53456 3776 46628808
Sputum retention 17.76 12.13 9 53469 415 46632169
Immobile 17.64 12.13 24 53454 4582 46628002
Hyponatraemic syndrome 17.59 12.13 10 53468 582 46632002
Rash pruritic 17.41 12.13 15 53463 44200 46588384
Renal impairment 17.36 12.13 37 53441 74335 46558249
Postural reflex impairment 17.32 12.13 3 53475 0 46632584
Cellulitis 17.22 12.13 34 53444 70254 46562330
Transient aphasia 17.02 12.13 5 53473 49 46632535
Dairy intolerance 17.02 12.13 5 53473 49 46632535
Aspartate aminotransferase increased 16.87 12.13 41 53437 78659 46553925
Red blood cell sedimentation rate increased 16.72 12.13 3 53475 22886 46609698
Pyramidal tract syndrome 16.71 12.13 8 53470 326 46632258
Tarsal tunnel syndrome 16.65 12.13 10 53468 645 46631939
Gastric perforation 16.64 12.13 13 53465 1289 46631295
Incoherent 16.51 12.13 23 53455 4489 46628095
Influenza 16.51 12.13 50 53428 89220 46543364
Wrist fracture 16.50 12.13 39 53439 11464 46621120
Serotonin syndrome 16.42 12.13 63 53415 24157 46608427
Pain in jaw 16.39 12.13 12 53466 38360 46594224
Constipation 16.25 12.13 285 53193 173812 46458772
Infrequent bowel movements 16.23 12.13 12 53466 1096 46631488
Chills 16.22 12.13 56 53422 95976 46536608
Locked-in syndrome 16.20 12.13 8 53470 349 46632235
Neuropathy peripheral 16.04 12.13 52 53426 90841 46541743
Bone marrow failure 15.93 12.13 7 53471 29662 46602922
Cerebellar haematoma 15.85 12.13 8 53470 366 46632218
Gastrooesophageal reflux disease 15.72 12.13 39 53439 74305 46558279
Pericarditis 15.72 12.13 4 53474 23923 46608661
Medical device site scab 15.63 12.13 4 53474 22 46632562
Progressive supranuclear palsy 15.54 12.13 5 53473 68 46632516
Inhibitory drug interaction 15.51 12.13 15 53463 1980 46630604
Rehabilitation therapy 15.45 12.13 12 53466 1180 46631404
Urge incontinence 15.32 12.13 10 53468 747 46631837
Deep vein thrombosis 15.24 12.13 44 53434 79729 46552855
Medical device site abscess 15.24 12.13 3 53475 3 46632581
Medical device site discolouration 15.24 12.13 3 53475 3 46632581
Medical device site vesicles 15.24 12.13 3 53475 3 46632581
Sedative therapy 15.24 12.13 3 53475 3 46632581
Propulsive gait 15.24 12.13 3 53475 3 46632581
Medication error 15.24 12.13 73 53405 30838 46601746
Pregnancy 15.22 12.13 6 53472 27131 46605453
Flushing 15.20 12.13 32 53446 64582 46568002
Nuchal rigidity 15.18 12.13 9 53469 567 46632017
Unresponsive to stimuli 15.16 12.13 75 53403 32099 46600485
Product use in unapproved indication 15.01 12.13 53 53425 90220 46542364
Dry eye 14.99 12.13 8 53470 30314 46602270
Supine hypertension 14.97 12.13 5 53473 77 46632507
Mouth ulceration 14.94 12.13 6 53472 26826 46605758
Hepatotoxicity 14.92 12.13 5 53473 25004 46607580
Device difficult to use 14.74 12.13 30 53448 7974 46624610
Multiple sclerosis 14.72 12.13 5 53473 24786 46607798
Gastrointestinal stoma complication 14.58 12.13 13 53465 1548 46631036
Heat stroke 14.54 12.13 9 53469 613 46631971
Purpura senile 14.37 12.13 9 53469 626 46631958
Screaming 14.35 12.13 18 53460 3173 46629411
Respiratory dyskinesia 14.34 12.13 4 53474 32 46632552
Saliva altered 14.27 12.13 7 53471 301 46632283
Unevaluable event 14.13 12.13 96 53382 46079 46586505
Pulmonary arterial hypertension 14.11 12.13 6 53472 25922 46606662
Persecutory delusion 14.11 12.13 16 53462 2539 46630045
Vitamin B6 decreased 14.03 12.13 3 53475 6 46632578
Vaccination site oedema 14.02 12.13 4 53474 35 46632549
Vestibular disorder 14.01 12.13 12 53466 1354 46631230
Fear of falling 14.00 12.13 6 53472 188 46632396
Vaccination site bruising 13.92 12.13 4 53474 36 46632548
Vaccination site pruritus 13.92 12.13 4 53474 36 46632548
Pulmonary fibrosis 13.91 12.13 3 53475 20089 46612495
Hepatic failure 13.57 12.13 11 53467 33405 46599179
Sleep disorder 13.56 12.13 96 53382 46699 46585885
Multiple sclerosis relapse 13.53 12.13 17 53461 42108 46590476
Catatonia 13.50 12.13 19 53459 3743 46628841
Dyspnoea exertional 13.50 12.13 23 53455 50266 46582318
Listless 13.43 12.13 14 53464 2021 46630563
Device use issue 13.43 12.13 12 53466 1433 46631151
Diabetes mellitus 13.35 12.13 23 53455 50042 46582542
Immune-mediated adverse reaction 13.22 12.13 6 53472 216 46632368
Impaired self-care 13.20 12.13 13 53465 1755 46630829
Delusion of parasitosis 13.17 12.13 3 53475 9 46632575
Cogwheel rigidity 13.11 12.13 12 53466 1478 46631106
Autonomic nervous system imbalance 13.07 12.13 15 53463 2411 46630173
Communication disorder 13.04 12.13 15 53463 2418 46630166
Hypernatraemia 13 12.13 25 53453 6376 46626208
Blood bilirubin increased 12.97 12.13 12 53466 34172 46598412
Mixed dementia 12.93 12.13 3 53475 10 46632574
Hypersomnia 12.90 12.13 43 53435 15396 46617188
Rash maculo-papular 12.86 12.13 8 53470 27866 46604718
Blood glucose increased 12.84 12.13 41 53437 71972 46560612
Acute abdomen 12.83 12.13 12 53466 1520 46631064
Haemoptysis 12.82 12.13 7 53471 26182 46606402
Mini mental status examination abnormal 12.71 12.13 3 53475 11 46632573
Tongue necrosis 12.71 12.13 3 53475 11 46632573
Wrong product administered 12.70 12.13 23 53455 5607 46626977
Cardiac failure congestive 12.64 12.13 58 53420 91692 46540892
Foetal exposure during pregnancy 12.64 12.13 10 53468 30737 46601847
Injection site haemorrhage 12.61 12.13 4 53474 20705 46611879
Device deposit issue 12.51 12.13 3 53475 12 46632572
Feeling abnormal 12.49 12.13 207 53271 124853 46507731
Osteoporosis 12.41 12.13 17 53461 40591 46591993
Hyperthermia 12.41 12.13 28 53450 7986 46624598
Pain in extremity 12.41 12.13 215 53263 258465 46374119
Product dose omission issue 12.37 12.13 266 53212 168254 46464330
Normochromic normocytic anaemia 12.37 12.13 20 53458 4452 46628132
Night sweats 12.33 12.13 8 53470 27242 46605342
Psychiatric symptom 12.28 12.13 20 53458 4477 46628107
Abdominal rigidity 12.24 12.13 12 53466 1610 46630974
Labelled drug-drug interaction medication error 12.23 12.13 30 53448 9031 46623553
Ear pain 12.20 12.13 5 53473 22087 46610497
Anaphylactic shock 12.19 12.13 4 53474 20270 46612314
Urine calcium/creatinine ratio increased 12.19 12.13 5 53473 140 46632444

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hallucination 2402.24 13.28 1430 63688 47629 29839731
On and off phenomenon 1873.30 13.28 540 64578 2351 29885009
Dyskinesia 1713.03 13.28 870 64248 20964 29866396
Device dislocation 1268.69 13.28 459 64659 4572 29882788
Freezing phenomenon 1251.24 13.28 361 64757 1575 29885785
Fall 1126.50 13.28 1658 63460 180214 29707146
Stoma site discharge 1096.57 13.28 308 64810 1193 29886167
Stoma site erythema 830.29 13.28 229 64889 815 29886545
Embedded device 645.95 13.28 164 64954 381 29886979
Hyperkinesia 583.80 13.28 206 64912 1892 29885468
Stoma site infection 573.08 13.28 168 64950 783 29886577
Hallucination, visual 552.31 13.28 376 64742 15737 29871623
Muscle rigidity 544.63 13.28 316 64802 9945 29877415
Confusional state 519.18 13.28 996 64122 133838 29753522
Bradykinesia 477.16 13.28 200 64918 3030 29884330
Delusion 474.35 13.28 306 64812 11683 29875677
Device occlusion 456.35 13.28 236 64882 5884 29881476
Stoma site pain 455.44 13.28 132 64986 586 29886774
Akinesia 441.72 13.28 176 64942 2324 29885036
Dopamine dysregulation syndrome 429.92 13.28 118 65000 410 29886950
Device issue 426.17 13.28 245 64873 7571 29879789
General physical health deterioration 416.22 13.28 764 64354 99180 29788180
Mobility decreased 412.94 13.28 386 64732 25613 29861747
Stoma site inflammation 398.89 13.28 115 65003 499 29886861
Hypersexuality 390.94 13.28 140 64978 1347 29886013
Dysphagia 388.26 13.28 544 64574 56154 29831206
Gait disturbance 376.82 13.28 622 64496 74155 29813205
Dementia 369.15 13.28 266 64852 12195 29875165
Impulse-control disorder 361.70 13.28 130 64988 1265 29886095
Stoma site hypergranulation 337.67 13.28 89 65029 253 29887107
Gambling disorder 323.20 13.28 129 64989 1711 29885649
Pneumonia aspiration 312.98 13.28 398 64720 37382 29849978
Tremor 304.50 13.28 569 64549 74794 29812566
Intentional medical device removal by patient 278.00 13.28 76 65042 259 29887101
Aggression 271.85 13.28 367 64751 36540 29850820
Cognitive disorder 271.83 13.28 295 64823 23395 29863965
Device kink 254.00 13.28 80 65038 495 29886865
Abnormal behaviour 251.21 13.28 294 64824 25329 29862031
Stoma site haemorrhage 246.69 13.28 88 65030 836 29886524
Device connection issue 239.45 13.28 74 65044 426 29886934
Stoma site reaction 210.96 13.28 58 65060 203 29887157
Restlessness 202.93 13.28 248 64870 22351 29865009
Fibroma 202.02 13.28 58 65060 247 29887113
Device alarm issue 199.81 13.28 72 65046 706 29886654
Dystonia 197.35 13.28 166 64952 9561 29877799
Somnolence 192.75 13.28 553 64565 96210 29791150
Toxicity to various agents 191.53 13.28 73 65045 177110 29710250
Febrile neutropenia 190.90 13.28 10 65108 106683 29780677
Parkinson's disease 187.06 13.28 86 65032 1642 29885718
Balance disorder 184.10 13.28 304 64814 36189 29851171
Stoma site extravasation 180.04 13.28 47 65071 127 29887233
Therapeutic product effect variable 178.68 13.28 78 65040 1311 29886049
Abnormal dreams 176.10 13.28 144 64974 7971 29879389
Diarrhoea 165.17 13.28 297 64821 333806 29553554
Agitation 163.17 13.28 362 64756 53711 29833649
Prescribed underdose 162.75 13.28 135 64983 7624 29879736
Orthostatic hypotension 154.92 13.28 224 64894 23755 29863605
Hypokinesia 149.54 13.28 125 64993 7135 29880225
Psychotic disorder 149.35 13.28 208 64910 21307 29866053
Urinary tract infection 148.55 13.28 423 64695 73236 29814124
Speech disorder 148.29 13.28 222 64896 24290 29863070
Hip fracture 140.79 13.28 146 64972 10978 29876382
Underdose 140.62 13.28 152 64966 11989 29875371
Neutropenia 138.73 13.28 53 65065 128487 29758873
Rash 131.62 13.28 134 64984 191755 29695605
Stoma site irritation 131.16 13.28 36 65082 125 29887235
Unintentional medical device removal 130.20 13.28 72 65046 2059 29885301
Incorrect route of product administration 129.90 13.28 141 64977 11174 29876186
Acute kidney injury 129.35 13.28 250 64868 273592 29613768
Platelet count decreased 128.14 13.28 36 65082 106093 29781267
Posture abnormal 127.86 13.28 68 65050 1796 29885564
Wrong technique in device usage process 127.54 13.28 55 65063 896 29886464
Nonspecific reaction 125.91 13.28 60 65058 1246 29886114
Stoma site odour 120.20 13.28 30 65088 63 29887297
Parkinsonism 119.30 13.28 110 65008 7159 29880201
Device breakage 116.51 13.28 61 65057 1559 29885801
Jealous delusion 116.51 13.28 37 65081 236 29887124
Parkinsonism hyperpyrexia syndrome 116.12 13.28 31 65087 94 29887266
Musculoskeletal stiffness 115.92 13.28 247 64871 35634 29851726
Memory impairment 115.63 13.28 252 64866 36922 29850438
Decubitus ulcer 114.72 13.28 111 65007 7677 29879683
Pancytopenia 114.17 13.28 23 65095 85029 29802331
Gait inability 113.03 13.28 170 64948 18671 29868689
Thrombocytopenia 111.80 13.28 81 65037 136963 29750397
Dysstasia 108.71 13.28 124 64994 10381 29876979
Reduced facial expression 107.53 13.28 46 65072 734 29886626
Malignant neoplasm progression 107.07 13.28 15 65103 72272 29815088
Deep brain stimulation 106.95 13.28 25 65093 34 29887326
Alanine aminotransferase increased 104.15 13.28 18 65100 74258 29813102
Death 102.31 13.28 1205 63913 356078 29531282
Compulsive shopping 102.22 13.28 38 65080 410 29886950
Delirium 101.77 13.28 253 64865 40378 29846982
Disorientation 101.16 13.28 216 64902 31202 29856158
Pruritus 100.19 13.28 67 65051 118137 29769223
Therapeutic response shortened 100.10 13.28 74 65044 3526 29883834
Dyspnoea 97.03 13.28 385 64733 332910 29554450
Nightmare 96.39 13.28 125 64993 11951 29875409
Poor quality sleep 95.17 13.28 97 65021 7144 29880216
Device deployment issue 93.49 13.28 26 65092 96 29887264
Paranoia 93.36 13.28 113 65005 10075 29877285
Device difficult to use 91.26 13.28 38 65080 565 29886795
Prescribed overdose 88.49 13.28 101 65017 8460 29878900
Headache 86.28 13.28 166 64952 182140 29705220
Bedridden 85.52 13.28 68 65050 3614 29883746
Arthralgia 85.10 13.28 102 65016 135689 29751671
Tension 81.39 13.28 48 65070 1555 29885805
Choking 79.52 13.28 74 65044 4872 29882488
Completed suicide 78.27 13.28 61 65057 99431 29787929
Aspartate aminotransferase increased 77.47 13.28 21 65097 63401 29823959
Device leakage 76.89 13.28 64 65054 3630 29883730
Stoma site discomfort 76.89 13.28 20 65098 53 29887307
Device expulsion 76.05 13.28 21 65097 75 29887285
Infusion related reaction 75.10 13.28 3 65115 40561 29846799
Sleep talking 74.75 13.28 31 65087 456 29886904
Drug hypersensitivity 74.27 13.28 28 65090 68491 29818869
Stoma site induration 73.70 13.28 19 65099 48 29887312
Neuroleptic malignant syndrome 73.21 13.28 129 64989 16166 29871194
Aspiration 71.70 13.28 101 65017 10450 29876910
Excessive granulation tissue 71.27 13.28 30 65088 459 29886901
Rheumatoid arthritis 70.19 13.28 5 65113 41192 29846168
Bezoar 70.10 13.28 36 65082 883 29886477
Hyperkalaemia 69.85 13.28 28 65090 65982 29821378
Anaemia 69.14 13.28 227 64891 207765 29679595
Parkinsonian gait 69.00 13.28 29 65089 442 29886918
Drooling 68.73 13.28 55 65063 2950 29884410
Renal failure 68.62 13.28 109 65009 128857 29758503
Cogwheel rigidity 68.35 13.28 38 65080 1098 29886262
Device physical property issue 68.15 13.28 32 65086 642 29886718
Movement disorder 67.74 13.28 95 65023 9788 29877572
Hypophagia 67.14 13.28 149 64969 22087 29865273
Plasma cell myeloma 66.63 13.28 17 65101 53445 29833915
White blood cell count decreased 66.62 13.28 51 65067 83896 29803464
Nocturia 66.27 13.28 86 65032 8226 29879134
Pyrexia 65.73 13.28 374 64744 294115 29593245
Urticaria 64.98 13.28 19 65099 54587 29832773
Stereotypy 64.77 13.28 29 65089 519 29886841
Foetal exposure during pregnancy 64.21 13.28 4 65114 36867 29850493
Nausea 64.21 13.28 381 64737 296576 29590784
Myalgia 64.19 13.28 44 65074 76623 29810737
Device use issue 63.50 13.28 21 65097 155 29887205
Psoriasis 62.50 13.28 9 65109 42497 29844863
Psychomotor hyperactivity 60.80 13.28 82 65036 8142 29879218
Sudden onset of sleep 59.99 13.28 26 65092 429 29886931
Renal impairment 59.65 13.28 57 65061 84127 29803233
Intentional device misuse 59.62 13.28 22 65096 232 29887128
Stomatitis 59.47 13.28 6 65112 37273 29850087
Femoral neck fracture 59.23 13.28 50 65068 2892 29884468
Motor dysfunction 58.25 13.28 68 65050 5834 29881526
Hypersomnia 57.99 13.28 95 65023 11221 29876139
Gambling 57.90 13.28 21 65097 210 29887150
Middle insomnia 57.79 13.28 67 65051 5706 29881654
Leukopenia 57.52 13.28 25 65093 56134 29831226
Resting tremor 56.91 13.28 27 65091 555 29886805
Feeling abnormal 56.57 13.28 259 64859 56497 29830863
Stoma site ulcer 56.06 13.28 15 65103 46 29887314
Blood creatinine increased 55.77 13.28 70 65048 91305 29796055
Fluid intake reduced 54.76 13.28 48 65070 2922 29884438
Stoma complication 54.16 13.28 19 65099 171 29887189
Obsessive-compulsive disorder 53.56 13.28 55 65063 4086 29883274
Sexually inappropriate behaviour 53.39 13.28 22 65096 318 29887042
Libido increased 52.89 13.28 29 65089 815 29886545
Septic shock 52.58 13.28 37 65081 63570 29823790
Cough 52.19 13.28 123 64995 125519 29761841
Chest pain 51.42 13.28 112 65006 117515 29769845
Vomiting 51.24 13.28 275 64843 219543 29667817
Angioedema 51.21 13.28 7 65111 34377 29852983
Interstitial lung disease 51.12 13.28 34 65084 60163 29827197
Rapid eye movement sleep behaviour disorder 50.93 13.28 16 65102 98 29887262
Off label use 50.62 13.28 326 64792 248964 29638396
Suspiciousness 50.54 13.28 22 65096 367 29886993
Stoma site oedema 49.88 13.28 12 65106 20 29887340
Device loosening 49.86 13.28 14 65104 54 29887306
Illusion 49.82 13.28 27 65091 741 29886619
Compulsive sexual behaviour 49.08 13.28 19 65099 231 29887129
Epistaxis 49.07 13.28 27 65091 52954 29834406
Loss of personal independence in daily activities 48.62 13.28 129 64989 21406 29865954
Product dose omission issue 48.35 13.28 353 64765 91278 29796082
Sleep disorder 47.73 13.28 139 64979 24340 29863020
Treatment failure 47.30 13.28 9 65109 34670 29852690
Rehabilitation therapy 47.09 13.28 24 65094 579 29886781
Anaphylactic reaction 45.97 13.28 4 65114 27978 29859382
Supine hypertension 45.07 13.28 18 65100 239 29887121
Paraphilia 44.95 13.28 14 65104 83 29887277
Fracture 44.57 13.28 60 65058 5946 29881414
Bone marrow failure 44.51 13.28 6 65112 29779 29857581
Oropharyngeal pain 44.39 13.28 5 65113 28491 29858869
Asthma 44.12 13.28 12 65106 36162 29851198
Enteral nutrition 43.43 13.28 12 65106 43 29887317
Cardiac failure congestive 43.31 13.28 73 65045 84334 29803026
Terminal state 43.27 13.28 46 65072 3558 29883802
Blood glucose increased 43.18 13.28 42 65076 61488 29825872
Hepatic enzyme increased 42.99 13.28 10 65108 33484 29853876
Neuropathy peripheral 42.98 13.28 54 65064 70421 29816939
Pancreatitis 42.85 13.28 13 65105 36477 29850883
Erythema 42.56 13.28 64 65054 77387 29809973
Constipation 42.46 13.28 403 64715 112503 29774857
Weight decreased 42.42 13.28 508 64610 150413 29736947
Hyperglycaemia 42.33 13.28 12 65106 35188 29852172
Initial insomnia 42.13 13.28 39 65079 2550 29884810
Volvulus 41.95 13.28 29 65089 1242 29886118
Therapeutic product effect incomplete 41.92 13.28 165 64953 33669 29853691
Fine motor skill dysfunction 41.91 13.28 28 65090 1133 29886227
Medical device removal 41.81 13.28 15 65103 145 29887215
Depressed mood 41.52 13.28 105 65013 16924 29870436
Injection site pain 41.05 13.28 8 65110 30302 29857058
Haemoglobin decreased 41.04 13.28 120 64998 113978 29773382
Hypersensitivity 40.14 13.28 35 65083 53993 29833367
Device placement issue 39.98 13.28 9 65109 9 29887351
Blood bilirubin increased 39.64 13.28 15 65103 36621 29850739
Product use in unapproved indication 39.43 13.28 62 65056 73631 29813729
Nasopharyngitis 39.21 13.28 42 65076 58807 29828553
Wheelchair user 38.96 13.28 25 65093 944 29886416
Impulsive behaviour 38.74 13.28 33 65085 1932 29885428
Influenza like illness 38.64 13.28 5 65113 25600 29861760
Chest discomfort 38.19 13.28 26 65092 45454 29841906
Salivary hypersecretion 38.07 13.28 63 65055 7503 29879857
Hepatic function abnormal 37.95 13.28 22 65096 41923 29845437
Chills 37.63 13.28 62 65056 72276 29815084
Disease progression 37.47 13.28 73 65045 79801 29807559
Product use complaint 37.35 13.28 26 65092 1126 29886234
Medical device site dryness 37.29 13.28 10 65108 31 29887329
Gastrostomy 37.27 13.28 22 65096 714 29886646
Apathy 37.03 13.28 56 65062 6176 29881184
Therapeutic product effect decreased 37.00 13.28 143 64975 28933 29858427
Camptocormia 36.94 13.28 14 65104 160 29887200
Medical device pain 36.88 13.28 11 65107 55 29887305
Ascites 36.76 13.28 16 65102 35905 29851455
Hepatic failure 36.73 13.28 14 65104 34029 29853331
Hypokalaemia 36.70 13.28 33 65085 50159 29837201
Head injury 36.45 13.28 100 65018 16920 29870440
Diabetes mellitus 36.41 13.28 23 65095 41842 29845518
Deep vein thrombosis 36.22 13.28 47 65071 60454 29826906
Coronary artery disease 35.97 13.28 33 65085 49679 29837681
Drug abuse 35.96 13.28 78 65040 81994 29805366
Dysarthria 35.62 13.28 146 64972 30344 29857016
Sinusitis 35.50 13.28 14 65104 33331 29854029
Chronic kidney disease 35.45 13.28 19 65099 37819 29849541
Inguinal hernia 35.23 13.28 59 65059 7096 29880264
Immobile 34.55 13.28 32 65086 2094 29885266
Dyspnoea exertional 34.37 13.28 17 65101 35413 29851947
Multiple organ dysfunction syndrome 34.35 13.28 53 65065 63434 29823926
Hepatocellular injury 33.92 13.28 7 65111 25464 29861896
Food interaction 33.76 13.28 22 65096 853 29886507
Drug reaction with eosinophilia and systemic symptoms 33.72 13.28 10 65108 28478 29858882
Tachycardia 33.21 13.28 69 65049 73670 29813690
Sepsis 33.04 13.28 185 64933 146210 29741150
Femur fracture 33.00 13.28 58 65060 7251 29880109
Gastrointestinal motility disorder 32.99 13.28 32 65086 2219 29885141
Behaviour disorder 32.95 13.28 33 65085 2379 29884981
Liver function test abnormal 32.94 13.28 13 65105 30937 29856423
Wheezing 32.92 13.28 13 65105 30925 29856435
Autonomic nervous system imbalance 32.85 13.28 33 65085 2388 29884972
Medical device discomfort 32.44 13.28 10 65108 57 29887303
Screaming 31.81 13.28 25 65093 1306 29886054
Heart rate increased 31.37 13.28 23 65095 38698 29848662
Therapeutic product effect delayed 31.29 13.28 23 65095 1086 29886274
Respiratory failure 31.22 13.28 113 65005 100529 29786831
Delusion of replacement 31.14 13.28 12 65106 144 29887216
Therapeutic response unexpected 30.72 13.28 63 65055 8840 29878520
Myocardial infarction 30.42 13.28 155 64963 125470 29761890
Anxiety 29.99 13.28 313 64805 89558 29797802
Atrial fibrillation 29.97 13.28 127 64991 107997 29779363
Communication disorder 29.87 13.28 30 65088 2170 29885190
Device power source issue 29.76 13.28 14 65104 282 29887078
Neutrophil count decreased 29.75 13.28 29 65089 42425 29844935
Osteonecrosis of jaw 29.68 13.28 3 65115 18615 29868745
Cellulitis 29.41 13.28 35 65083 46749 29840611
Daydreaming 29.04 13.28 16 65102 454 29886906
Therapy non-responder 28.77 13.28 14 65104 29439 29857921
Persecutory delusion 28.72 13.28 29 65089 2111 29885249
Joint swelling 28.58 13.28 36 65082 46910 29840450
Dementia with Lewy bodies 28.49 13.28 17 65101 563 29886797
Chronic obstructive pulmonary disease 28.47 13.28 35 65083 46091 29841269
Acute myeloid leukaemia 28.45 13.28 3 65115 18003 29869357
Progressive supranuclear palsy 28.26 13.28 9 65109 58 29887302
Hypocalcaemia 28.20 13.28 6 65112 21370 29865990
Fluid overload 28.16 13.28 4 65114 19088 29868272
Multiple system atrophy 27.80 13.28 12 65106 196 29887164
Blood alkaline phosphatase increased 27.79 13.28 17 65101 31470 29855890
Hallucination, auditory 27.76 13.28 64 65054 9725 29877635
Liver disorder 27.73 13.28 15 65103 29707 29857653
Gastrointestinal haemorrhage 27.70 13.28 91 65027 83355 29804005
Myelodysplastic syndrome 27.54 13.28 4 65114 18774 29868586
Rapid eye movements sleep abnormal 27.41 13.28 12 65106 203 29887157
Intentional overdose 27.19 13.28 30 65088 41451 29845909
Chorea 27.17 13.28 21 65097 1070 29886290
Nasal congestion 27.13 13.28 4 65114 18562 29868798
Swelling 27.09 13.28 23 65095 35952 29851408
Back pain 26.92 13.28 123 64995 102473 29784887
Hallucinations, mixed 26.86 13.28 30 65088 2453 29884907
Pain 26.82 13.28 243 64875 172398 29714962
Mental disorder 26.82 13.28 77 65041 13372 29873988
Hypoxia 26.80 13.28 39 65079 47815 29839545
Postoperative delirium 26.50 13.28 8 65110 42 29887318
Acute psychosis 26.24 13.28 26 65092 1850 29885510
Acute myocardial infarction 26.04 13.28 47 65071 52892 29834468
Lactic acidosis 25.99 13.28 18 65100 31195 29856165
Abnormal faeces 25.89 13.28 30 65088 2553 29884807
Disturbance in attention 25.87 13.28 106 65012 22023 29865337
Product availability issue 25.48 13.28 17 65101 686 29886674
Inflammatory marker increased 25.43 13.28 33 65085 3155 29884205
Postural reflex impairment 25.32 13.28 6 65112 9 29887351
Medical device site injury 25.32 13.28 6 65112 9 29887351
Device colour issue 25.32 13.28 6 65112 9 29887351
Euthanasia 25.19 13.28 8 65110 51 29887309
Stoma site abscess 25.06 13.28 8 65110 52 29887308
Fatigue 24.95 13.28 520 64598 320153 29567207
Device programming error 24.94 13.28 6 65112 10 29887350
Medical device change 24.89 13.28 10 65108 135 29887225
Acute respiratory distress syndrome 24.74 13.28 10 65108 23462 29863898
Hypertension 24.40 13.28 159 64959 121195 29766165
Intentional product use issue 24.28 13.28 26 65092 36414 29850946
Parkinsonian crisis 24.24 13.28 6 65112 12 29887348
Disseminated intravascular coagulation 24.11 13.28 9 65109 22162 29865198
Dyschezia 23.94 13.28 20 65098 1140 29886220
Cardiogenic shock 23.80 13.28 4 65114 16857 29870503
Food refusal 23.52 13.28 10 65108 157 29887203
Rhabdomyolysis 23.48 13.28 66 65052 63514 29823846
Pneumoperitoneum 23.45 13.28 23 65095 1617 29885743
Product use issue 23.40 13.28 40 65078 45976 29841384
Marital problem 23.10 13.28 8 65110 69 29887291
Jaundice 22.98 13.28 22 65096 32464 29854896
Suspected COVID-19 22.98 13.28 12 65106 305 29887055
Obsessive-compulsive personality disorder 22.91 13.28 10 65108 168 29887192
Hepatitis 22.80 13.28 10 65108 22346 29865014
Sleep attacks 22.80 13.28 10 65108 170 29887190
Pelvic fracture 22.73 13.28 26 65092 2182 29885178
Insomnia 22.70 13.28 306 64812 93030 29794330
Metabolic acidosis 22.52 13.28 29 65089 37432 29849928
Incontinence 22.43 13.28 41 65077 5285 29882075
Vitamin B6 decreased 22.21 13.28 5 65113 5 29887355
Compulsions 22.18 13.28 10 65108 182 29887178
Hepatotoxicity 22.16 13.28 6 65112 18139 29869221
Anosmia 22.08 13.28 25 65093 2075 29885285
Rash maculo-papular 22.05 13.28 14 65104 25404 29861956
Feeding disorder 22.00 13.28 43 65075 5828 29881532
Polyneuropathy 21.96 13.28 66 65052 11757 29875603
Arthritis 21.78 13.28 13 65105 24388 29862972
Palliative care 21.76 13.28 12 65106 341 29887019
Fear of falling 21.76 13.28 12 65106 341 29887019
Syncope 21.75 13.28 281 64837 84622 29802738
Upper limb fracture 21.66 13.28 35 65083 4085 29883275
Panic attack 21.65 13.28 54 65064 8627 29878733
Medical device site erosion 21.61 13.28 7 65111 48 29887312
Coronavirus infection 21.59 13.28 32 65086 3466 29883894
Pneumonitis 21.35 13.28 17 65101 27437 29859923
Saliva discolouration 21.31 13.28 5 65113 7 29887353
Micturition urgency 21.24 13.28 36 65082 4371 29882989
Skin exfoliation 21.17 13.28 12 65106 23160 29864200
Torticollis 21.09 13.28 18 65100 1057 29886303
Medical device site warmth 20.91 13.28 5 65113 8 29887352
Hepatic encephalopathy 20.87 13.28 3 65115 14189 29873171
Phlebitis infective 20.74 13.28 9 65109 149 29887211
Gout 20.63 13.28 6 65112 17309 29870051
Compulsive hoarding 20.63 13.28 6 65112 27 29887333
Complication of device insertion 20.61 13.28 8 65110 98 29887262
Wrong technique in product usage process 20.60 13.28 127 64991 31028 29856332
Blood pressure fluctuation 20.58 13.28 84 65034 17419 29869941
Anger 20.58 13.28 62 65056 11058 29876302
Drug resistance 20.54 13.28 9 65109 20124 29867236
Alien limb syndrome 20.54 13.28 5 65113 9 29887351
Proteinuria 20.36 13.28 5 65113 16140 29871220
Thrombosis 20.31 13.28 38 65080 42193 29845167
Hypoglycaemia 20.28 13.28 51 65067 50930 29836430
Neoplasm progression 20.13 13.28 7 65111 18016 29869344
Gastrointestinal stoma complication 20.13 13.28 19 65099 1273 29886087
Saliva altered 20.00 13.28 9 65109 163 29887197
Dry skin 19.99 13.28 12 65106 22442 29864918
Tubulointerstitial nephritis 19.90 13.28 7 65111 17884 29869476
COVID-19 19.62 13.28 84 65034 17794 29869566
Serotonin syndrome 19.59 13.28 84 65034 17807 29869553
Oedema 19.54 13.28 40 65078 42953 29844407
Vitamin B6 deficiency 19.42 13.28 9 65109 175 29887185
Hypomagnesaemia 19.33 13.28 6 65112 16592 29870768
Impaired self-care 19.30 13.28 16 65102 902 29886458
Pleural effusion 19.29 13.28 89 65029 73977 29813383
Voyeurism 19.29 13.28 5 65113 13 29887347
Herpes zoster 19.25 13.28 22 65096 29921 29857439
Nasal discomfort 19.24 13.28 18 65100 1193 29886167
Influenza 19.20 13.28 41 65077 43357 29844003
Infrequent bowel movements 19.20 13.28 14 65104 653 29886707
Sinus tachycardia 19.17 13.28 5 65113 15499 29871861
Palpitations 19.16 13.28 27 65091 33546 29853814
Catheter site discharge 19.13 13.28 13 65105 541 29886819
Unresponsive to stimuli 18.94 13.28 110 65008 26309 29861051
Gastric perforation 18.93 13.28 23 65095 2058 29885302
Somatic delusion 18.91 13.28 8 65110 124 29887236
Mitral valve sclerosis 18.68 13.28 8 65110 128 29887232
Bone pain 18.65 13.28 9 65109 19017 29868343
Cerebral atrophy 18.51 13.28 34 65084 4399 29882961
Binge eating 18.47 13.28 7 65111 80 29887280
Secretion discharge 18.41 13.28 31 65087 3744 29883616
Skin ulcer 18.34 13.28 9 65109 18840 29868520
Anaphylactic shock 18.31 13.28 4 65114 13989 29873371
Economic problem 18.21 13.28 19 65099 1438 29885922
Mastication disorder 18.19 13.28 17 65101 1125 29886235
Hallucination, tactile 18.17 13.28 10 65108 283 29887077
Medical device site pain 18.16 13.28 7 65111 84 29887276
Urinary incontinence 18.13 13.28 79 65039 16861 29870499
Mixed dementia 18.09 13.28 9 65109 206 29887154
International normalised ratio increased 18.03 13.28 49 65069 47690 29839670
Oesophageal achalasia 17.95 13.28 10 65108 290 29887070
Feeding tube user 17.83 13.28 6 65112 47 29887313
Sexual inhibition 17.77 13.28 4 65114 4 29887356
Stoma site pruritus 17.77 13.28 4 65114 4 29887356
Medical device site abscess 17.77 13.28 4 65114 4 29887356
Alopecia 17.58 13.28 10 65108 19265 29868095
Hypercalcaemia 17.56 13.28 3 65115 12492 29874868
Bradyphrenia 17.35 13.28 31 65087 3926 29883434
Splenomegaly 17.35 13.28 4 65114 13476 29873884
Pneumothorax 16.90 13.28 7 65111 16186 29871174
Panic reaction 16.79 13.28 18 65100 1405 29885955
Upper respiratory tract infection 16.79 13.28 21 65097 27455 29859905
Soft tissue haemorrhage 16.70 13.28 8 65110 168 29887192
Renal disorder 16.65 13.28 16 65102 23568 29863792
Angina pectoris 16.58 13.28 24 65094 29494 29857866
Excessive masturbation 16.58 13.28 7 65111 108 29887252
Medical device site scab 16.50 13.28 4 65114 7 29887353
Medical device site discolouration 16.50 13.28 4 65114 7 29887353
Transaminases increased 16.46 13.28 16 65102 23441 29863919
Colitis 16.40 13.28 26 65092 30794 29856566
Decreased interest 16.40 13.28 22 65096 2173 29885187
Pain in extremity 16.29 13.28 157 64961 110064 29777296
Respiratory dyskinesia 16.29 13.28 5 65113 28 29887332
Hypertonia 16.29 13.28 32 65086 4353 29883007
Drug interaction 16.25 13.28 321 64797 199247 29688113
Hepatic steatosis 16.09 13.28 6 65112 14787 29872573
Thunderclap headache 16.03 13.28 6 65112 66 29887294
Verbal abuse 16.00 13.28 8 65110 185 29887175
Ventricular tachycardia 15.92 13.28 17 65101 23845 29863515
Osteomyelitis 15.89 13.28 6 65112 14675 29872685
Nervousness 15.83 13.28 59 65059 11729 29875631
Impaired quality of life 15.83 13.28 18 65100 1501 29885859
Haemoptysis 15.81 13.28 27 65091 31051 29856309
Flushing 15.58 13.28 25 65093 29467 29857893
Lymphadenopathy 15.57 13.28 18 65100 24358 29863002
Colitis ulcerative 15.46 13.28 6 65112 14428 29872932
Psychotic behaviour 15.43 13.28 11 65107 495 29886865
Poisoning 15.42 13.28 3 65115 11379 29875981
Soft tissue mass 15.42 13.28 9 65109 286 29887074
Fluid replacement 15.40 13.28 3 65115 0 29887360
Gamma-glutamyltransferase increased 15.40 13.28 25 65093 29325 29858035
Grimacing 15.39 13.28 9 65109 287 29887073
Medical device site discharge 15.35 13.28 5 65113 35 29887325
Dependence 15.34 13.28 16 65102 1210 29886150
Drug intolerance 15.29 13.28 49 65069 45242 29842118
Medical device site ulcer 15.27 13.28 4 65114 11 29887349
Emotional disorder 15.22 13.28 34 65084 5060 29882300
Blood cholesterol increased 15.20 13.28 9 65109 16961 29870399
Hyperbilirubinaemia 15.16 13.28 9 65109 16933 29870427
Hepatic cirrhosis 15.03 13.28 8 65110 15991 29871369
Faecaloma 15.00 13.28 31 65087 4374 29882986
Delusional disorder, unspecified type 14.98 13.28 13 65105 781 29886579
Rash erythematous 14.97 13.28 16 65102 22436 29864924
Coagulopathy 14.95 13.28 11 65107 18476 29868884
Electrocardiogram QT prolonged 14.92 13.28 35 65083 35800 29851560
Medical device site infection 14.91 13.28 8 65110 215 29887145
Hyperthermia 14.80 13.28 52 65066 10047 29877313
Patient uncooperative 14.79 13.28 7 65111 143 29887217
Defiant behaviour 14.77 13.28 4 65114 13 29887347
Tricuspid valve sclerosis 14.77 13.28 5 65113 40 29887320
Obsessive thoughts 14.75 13.28 12 65106 659 29886701
Marasmus 14.57 13.28 11 65107 541 29886819
Anticholinergic syndrome 14.56 13.28 13 65105 811 29886549
Protrusion tongue 14.46 13.28 8 65110 229 29887131
Migraine 14.38 13.28 5 65113 12869 29874491
Eye haematoma 14.35 13.28 5 65113 44 29887316
Gastric fistula 14.25 13.28 5 65113 45 29887315
Hypermobility syndrome 14.18 13.28 8 65110 238 29887122
Pericardial effusion 14.18 13.28 15 65103 21129 29866231
Decreased activity 14.15 13.28 27 65091 3594 29883766
Skin maceration 14.13 13.28 4 65114 16 29887344
Toxic epidermal necrolysis 14.09 13.28 11 65107 17929 29869431
Electrocardiogram QT interval 14.06 13.28 5 65113 47 29887313
Contraindicated product prescribed 14.02 13.28 9 65109 340 29887020
Nephropathy toxic 14.01 13.28 3 65115 10636 29876724
Wrong device used 13.94 13.28 4 65114 17 29887343
Cystitis 13.93 13.28 45 65073 8329 29879031
Adrenal insufficiency 13.67 13.28 3 65115 10460 29876900
Eosinophilic fasciitis 13.63 13.28 6 65112 103 29887257
Ventricular fibrillation 13.60 13.28 8 65110 15130 29872230
Cervical vertebral fracture 13.59 13.28 18 65100 1756 29885604
Device material issue 13.58 13.28 4 65114 19 29887341
Stevens-Johnson syndrome 13.49 13.28 11 65107 17545 29869815
Drug eruption 13.44 13.28 11 65107 17515 29869845
Mood altered 13.43 13.28 44 65074 8206 29879154
Blood lactate dehydrogenase increased 13.39 13.28 15 65103 20586 29866774
Medical device site necrosis 13.33 13.28 3 65115 3 29887357
Device-device incompatibility 13.33 13.28 3 65115 3 29887357
Propulsive gait 13.33 13.28 3 65115 3 29887357
Stoma site hypersensitivity 13.33 13.28 3 65115 3 29887357
Medical device battery replacement 13.33 13.28 3 65115 3 29887357
Social stay hospitalisation 13.33 13.28 3 65115 3 29887357
Medical device site granuloma 13.33 13.28 3 65115 3 29887357
Stoma site cellulitis 13.33 13.28 3 65115 3 29887357
Foreign body in throat 13.28 13.28 5 65113 56 29887304

Pharmacologic Action:

SourceCodeDescription
ATC N04BA01 NERVOUS SYSTEM
ANTI-PARKINSON DRUGS
DOPAMINERGIC AGENTS
Dopa and dopa derivatives
ATC N04BA02 NERVOUS SYSTEM
ANTI-PARKINSON DRUGS
DOPAMINERGIC AGENTS
Dopa and dopa derivatives
ATC N04BA03 NERVOUS SYSTEM
ANTI-PARKINSON DRUGS
DOPAMINERGIC AGENTS
Dopa and dopa derivatives
FDA CS M0370111 Amino Acids, Aromatic
MeSH PA D018726 Anti-Dyskinesia Agents
MeSH PA D000978 Antiparkinson Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D015259 Dopamine Agents
MeSH PA D018377 Neurotransmitter Agents
CHEBI has role CHEBI:35219 plant growth inhibitors
CHEBI has role CHEBI:48407 antiparkinson agent
CHEBI has role CHEBI:48560 dopamine agents
CHEBI has role CHEBI:50266 prodrugs
CHEBI has role CHEBI:50910 agente neurotoxico
CHEBI has role CHEBI:59174 haptens
CHEBI has role CHEBI:62215 allelochemicals
CHEBI has role CHEBI:66956 antidyskinetic drugs
CHEBI has role CHEBI:75771 mus musculus metabolite
CHEBI has role CHEBI:76924 plant metabolites
CHEBI has role CHEBI:77746 h. sapiens metabolites
FDA EPC N0000193220 Aromatic Amino Acid

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Postencephalitic parkinsonism indication 19972008 DOID:14332
Parkinsonism indication 32798002
Parkinson's disease indication 49049000 DOID:14330
Restless legs off-label use 32914008 DOID:0050425
Age-related macular degeneration off-label use 267718000 DOID:10871
Suicidal thoughts contraindication 6471006
Hallucinations contraindication 7011001
Dyskinesia contraindication 9748009
Peptic ulcer contraindication 13200003 DOID:750
Disorder of lung contraindication 19829001 DOID:850
Myocardial infarction contraindication 22298006 DOID:5844
Orthostatic hypotension contraindication 28651003
Obstruction of bile duct contraindication 30144000
Depressive disorder contraindication 35489007
Conduction disorder of the heart contraindication 44808001
Duodenal ulcer disease contraindication 51868009 DOID:1724
Diarrhea contraindication 62315008
Psychotic disorder contraindication 69322001
Diabetes mellitus contraindication 73211009 DOID:9351
Gastrointestinal hemorrhage contraindication 74474003
Open-angle glaucoma contraindication 84494001 DOID:1067
Kidney disease contraindication 90708001 DOID:557
Acute disease of cardiovascular system contraindication 128487001
Seizure disorder contraindication 128613002
Drug-induced psychosis contraindication 191483003 DOID:1742
Disease of liver contraindication 235856003 DOID:409
Retention of urine contraindication 267064002
Psychoneurotic personality disorder contraindication 268634009
Malignant melanoma contraindication 372244006
Angle-closure glaucoma contraindication 392291006 DOID:13550
Cardiovascular event risk contraindication 395112001
Gastric ulcer contraindication 397825006 DOID:10808

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.31 acidic
pKa2 9.07 acidic
pKa3 13.05 acidic
pKa4 10.01 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
42MG INBRIJA ACORDA N209184 Dec. 21, 2018 RX POWDER INHALATION Dec. 21, 2021 NEW PRODUCT
4.63MG/ML;20MG/ML DUOPA ABBVIE INC N203952 Jan. 9, 2015 RX SUSPENSION ENTERAL Jan. 9, 2022 TREATMENT OF MOTOR FLUCTUATIONS IN PATIENTS WITH ADVANCED PARKINSONS DISEASE

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(2) dopamine receptor GPCR AGONIST WOMBAT-PK SCIENTIFIC LITERATURE
D(1A) dopamine receptor GPCR AGONIST WOMBAT-PK SCIENTIFIC LITERATURE
Epidermal growth factor receptor Kinase IC50 5.54 DRUG MATRIX
Tyrosine-protein kinase Lck Kinase IC50 5.43 DRUG MATRIX
Tyrosine-protein kinase Fyn Kinase IC50 5.67 DRUG MATRIX
Arachidonate 15-lipoxygenase Enzyme IC50 5.65 DRUG MATRIX

External reference:

IDSource
4017790 VUID
N0000146151 NUI
D00059 KEGG_DRUG
4017790 VANDF
C0023570 UMLSCUI
CHEBI:15765 CHEBI
DAH PDB_CHEM_ID
TY3 PDB_CHEM_ID
6047 PUBCHEM_CID
CHEMBL1009 ChEMBL_ID
DB01235 DRUGBANK_ID
D004295 MESH_DESCRIPTOR_UI
D007980 MESH_DESCRIPTOR_UI
3639 IUPHAR_LIGAND_ID
2651 INN_ID
46627O600J UNII
6375 RXNORM
1804 MMSL
4971 MMSL
d00277 MMSL
001639 NDDF
15383004 SNOMEDCT_US
387086006 SNOMEDCT_US
65955006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
SINEMET HUMAN PRESCRIPTION DRUG LABEL 2 0006-3915 TABLET 100 mg ORAL NDA 25 sections
SINEMET HUMAN PRESCRIPTION DRUG LABEL 2 0006-3916 TABLET 100 mg ORAL NDA 25 sections
SINEMET HUMAN PRESCRIPTION DRUG LABEL 2 0006-3917 TABLET 250 mg ORAL NDA 25 sections
SINEMET HUMAN PRESCRIPTION DRUG LABEL 2 0006-6722 TABLET 100 mg ORAL NDA 25 sections
SINEMET HUMAN PRESCRIPTION DRUG LABEL 2 0006-6723 TABLET 250 mg ORAL NDA 25 sections
SINEMET HUMAN PRESCRIPTION DRUG LABEL 2 0006-6724 TABLET 100 mg ORAL NDA 25 sections
Duopa HUMAN PRESCRIPTION DRUG LABEL 2 0074-3012 SUSPENSION 20 mg ENTERAL NDA 27 sections
Stalevo HUMAN PRESCRIPTION DRUG LABEL 3 0078-0407 TABLET, FILM COATED 50 mg ORAL NDA 25 sections
Stalevo HUMAN PRESCRIPTION DRUG LABEL 3 0078-0408 TABLET, FILM COATED 100 mg ORAL NDA 25 sections
Stalevo HUMAN PRESCRIPTION DRUG LABEL 3 0078-0409 TABLET, FILM COATED 150 mg ORAL NDA 25 sections
Stalevo HUMAN PRESCRIPTION DRUG LABEL 3 0078-0527 TABLET, FILM COATED 200 mg ORAL NDA 25 sections
Stalevo HUMAN PRESCRIPTION DRUG LABEL 3 0078-0544 TABLET, FILM COATED 75 mg ORAL NDA 25 sections
Stalevo HUMAN PRESCRIPTION DRUG LABEL 3 0078-0545 TABLET, FILM COATED 125 mg ORAL NDA 25 sections
Carbidopa and levodopa HUMAN PRESCRIPTION DRUG LABEL 2 0228-2538 TABLET 100 mg ORAL ANDA 11 sections
Carbidopa and levodopa HUMAN PRESCRIPTION DRUG LABEL 2 0228-2539 TABLET 100 mg ORAL ANDA 11 sections
Carbidopa and levodopa HUMAN PRESCRIPTION DRUG LABEL 2 0228-2540 TABLET 250 mg ORAL ANDA 11 sections
Carbidopa and Levodopa HUMAN PRESCRIPTION DRUG LABEL 2 0378-0078 TABLET 100 mg ORAL ANDA 24 sections
Carbidopa and Levodopa HUMAN PRESCRIPTION DRUG LABEL 2 0378-0085 TABLET 100 mg ORAL ANDA 24 sections
Carbidopa and Levodopa HUMAN PRESCRIPTION DRUG LABEL 2 0378-0088 TABLET, EXTENDED RELEASE 100 mg ORAL ANDA 24 sections
Carbidopa and Levodopa HUMAN PRESCRIPTION DRUG LABEL 2 0378-0094 TABLET, EXTENDED RELEASE 200 mg ORAL ANDA 24 sections
Carbidopa and Levodopa HUMAN PRESCRIPTION DRUG LABEL 2 0378-1133 TABLET 250 mg ORAL ANDA 24 sections
Carbidopa, Levodopa and Entacapone HUMAN PRESCRIPTION DRUG LABEL 3 0378-8300 TABLET, FILM COATED 50 mg ORAL NDA authorized generic 24 sections
Carbidopa, Levodopa and Entacapone HUMAN PRESCRIPTION DRUG LABEL 3 0378-8301 TABLET, FILM COATED 75 mg ORAL NDA authorized generic 24 sections
Carbidopa, Levodopa and Entacapone HUMAN PRESCRIPTION DRUG LABEL 3 0378-8302 TABLET, FILM COATED 100 mg ORAL NDA authorized generic 24 sections
Carbidopa, Levodopa and Entacapone HUMAN PRESCRIPTION DRUG LABEL 3 0378-8303 TABLET, FILM COATED 125 mg ORAL NDA authorized generic 24 sections
Carbidopa, Levodopa and Entacapone HUMAN PRESCRIPTION DRUG LABEL 3 0378-8304 TABLET, FILM COATED 150 mg ORAL NDA authorized generic 24 sections
Carbidopa, Levodopa and Entacapone HUMAN PRESCRIPTION DRUG LABEL 3 0378-8305 TABLET, FILM COATED 200 mg ORAL NDA authorized generic 24 sections
Carbidopa and Levodopa HUMAN PRESCRIPTION DRUG LABEL 2 0615-4568 TABLET, EXTENDED RELEASE 200 mg ORAL ANDA 11 sections
Carbidopa and Levodopa HUMAN PRESCRIPTION DRUG LABEL 2 0615-4569 TABLET, EXTENDED RELEASE 100 mg ORAL ANDA 11 sections
Carbidopa and levodopa HUMAN PRESCRIPTION DRUG LABEL 2 0615-8067 TABLET 100 mg ORAL ANDA 12 sections