Stem definition | Drug id | CAS RN |
---|---|---|
dopamine receptor agonists, dopamine derivatives, used as antiparkinsonism/prolactin inhibitors | 1567 | 59-92-7 |
Dose | Unit | Route |
---|---|---|
3.50 | g | O |
0.60 | g | O |
0.45 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 1.65 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 674.47 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 41 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 1.70 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 23 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.76 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 1.30 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Sept. 19, 2019 | EMA | Acorda Therapeutics Ireland Limited | |
June 4, 1970 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Dyskinesia | 1869.51 | 12.13 | 826 | 52652 | 28099 | 46604485 |
On and off phenomenon | 1506.31 | 12.13 | 368 | 53110 | 1623 | 46630961 |
Hallucination | 1498.61 | 12.13 | 847 | 52631 | 49104 | 46583480 |
Stoma site discharge | 1328.43 | 12.13 | 331 | 53147 | 1609 | 46630975 |
Freezing phenomenon | 966.27 | 12.13 | 243 | 53235 | 1234 | 46631350 |
Stoma site erythema | 779.15 | 12.13 | 195 | 53283 | 967 | 46631617 |
Fall | 722.18 | 12.13 | 1322 | 52156 | 327775 | 46304809 |
Hyperkinesia | 702.36 | 12.13 | 197 | 53281 | 1615 | 46630969 |
Stoma site pain | 643.86 | 12.13 | 165 | 53313 | 915 | 46631669 |
Device dislocation | 634.64 | 12.13 | 363 | 53115 | 21439 | 46611145 |
Stoma site infection | 525.25 | 12.13 | 133 | 53345 | 697 | 46631887 |
Hallucination, visual | 513.20 | 12.13 | 295 | 53183 | 17578 | 46615006 |
Bradykinesia | 465.12 | 12.13 | 174 | 53304 | 3792 | 46628792 |
Muscle rigidity | 454.71 | 12.13 | 224 | 53254 | 9737 | 46622847 |
General physical health deterioration | 426.77 | 12.13 | 591 | 52887 | 115178 | 46517406 |
Tremor | 397.55 | 12.13 | 571 | 52907 | 115068 | 46517516 |
Akinesia | 390.22 | 12.13 | 125 | 53353 | 1676 | 46630908 |
Stoma site hypergranulation | 387.05 | 12.13 | 94 | 53384 | 401 | 46632183 |
Device occlusion | 348.96 | 12.13 | 159 | 53319 | 5786 | 46626798 |
Stoma site inflammation | 348.31 | 12.13 | 90 | 53388 | 518 | 46632066 |
Delusion | 321.99 | 12.13 | 185 | 53293 | 11003 | 46621581 |
Confusional state | 314.86 | 12.13 | 615 | 52863 | 159277 | 46473307 |
Gait disturbance | 276.53 | 12.13 | 551 | 52927 | 144712 | 46487872 |
Stoma site extravasation | 268.51 | 12.13 | 67 | 53411 | 327 | 46632257 |
Dystonia | 263.63 | 12.13 | 163 | 53315 | 11094 | 46621490 |
Device issue | 254.56 | 12.13 | 199 | 53279 | 19781 | 46612803 |
Dopamine dysregulation syndrome | 239.44 | 12.13 | 57 | 53421 | 219 | 46632365 |
Stoma site irritation | 233.05 | 12.13 | 56 | 53422 | 226 | 46632358 |
Parkinson's disease | 227.03 | 12.13 | 80 | 53398 | 1459 | 46631125 |
Parkinsonism | 211.68 | 12.13 | 125 | 53353 | 7823 | 46624761 |
Dysphagia | 210.61 | 12.13 | 343 | 53135 | 76969 | 46555615 |
Rheumatoid arthritis | 208.70 | 12.13 | 18 | 53460 | 240197 | 46392387 |
Dementia | 199.54 | 12.13 | 153 | 53325 | 14777 | 46617807 |
Stoma site reaction | 198.23 | 12.13 | 50 | 53428 | 257 | 46632327 |
Mobility decreased | 185.98 | 12.13 | 284 | 53194 | 60310 | 46572274 |
Therapeutic response shortened | 185.31 | 12.13 | 99 | 53379 | 5100 | 46627484 |
Impulse-control disorder | 178.07 | 12.13 | 55 | 53423 | 649 | 46631935 |
Fibroma | 174.99 | 12.13 | 58 | 53420 | 871 | 46631713 |
Device connection issue | 171.70 | 12.13 | 53 | 53425 | 624 | 46631960 |
Delirium | 170.90 | 12.13 | 212 | 53266 | 37016 | 46595568 |
Orthostatic hypotension | 168.98 | 12.13 | 173 | 53305 | 24485 | 46608099 |
Cognitive disorder | 162.87 | 12.13 | 206 | 53272 | 36677 | 46595907 |
Rash | 161.63 | 12.13 | 105 | 53373 | 356407 | 46276177 |
Device kink | 160.80 | 12.13 | 66 | 53412 | 1852 | 46630732 |
Pneumoperitoneum | 152.86 | 12.13 | 59 | 53419 | 1403 | 46631181 |
Therapeutic product effect variable | 151.03 | 12.13 | 54 | 53424 | 1029 | 46631555 |
Headache | 141.52 | 12.13 | 206 | 53272 | 478146 | 46154438 |
Hypophagia | 139.52 | 12.13 | 170 | 53308 | 29136 | 46603448 |
Psychotic disorder | 139.45 | 12.13 | 150 | 53328 | 22471 | 46610113 |
Stoma site haemorrhage | 137.08 | 12.13 | 49 | 53429 | 933 | 46631651 |
Hypokinesia | 136.09 | 12.13 | 109 | 53369 | 11213 | 46621371 |
Somnolence | 132.25 | 12.13 | 437 | 53041 | 156084 | 46476500 |
Parkinsonism hyperpyrexia syndrome | 130.91 | 12.13 | 32 | 53446 | 141 | 46632443 |
Stoma site odour | 127.64 | 12.13 | 27 | 53451 | 50 | 46632534 |
Hip fracture | 126.33 | 12.13 | 154 | 53324 | 26402 | 46606182 |
Speech disorder | 120.18 | 12.13 | 176 | 53302 | 35991 | 46596593 |
Compulsive shopping | 119.84 | 12.13 | 42 | 53436 | 753 | 46631831 |
Reduced facial expression | 119.64 | 12.13 | 47 | 53431 | 1173 | 46631411 |
Drug hypersensitivity | 118.51 | 12.13 | 66 | 53412 | 243759 | 46388825 |
Pneumonia aspiration | 115.60 | 12.13 | 161 | 53317 | 31444 | 46601140 |
Neuroleptic malignant syndrome | 114.75 | 12.13 | 98 | 53380 | 11024 | 46621560 |
Arthralgia | 114.72 | 12.13 | 150 | 53328 | 364453 | 46268131 |
Diarrhoea | 113.57 | 12.13 | 301 | 53177 | 559301 | 46073283 |
Abnormal dreams | 113.11 | 12.13 | 94 | 53384 | 10185 | 46622399 |
Restlessness | 111.77 | 12.13 | 142 | 53336 | 25382 | 46607202 |
Abnormal behaviour | 109.85 | 12.13 | 128 | 53350 | 20930 | 46611654 |
Underdose | 102.21 | 12.13 | 119 | 53359 | 19439 | 46613145 |
Disorientation | 98.00 | 12.13 | 162 | 53316 | 36756 | 46595828 |
Infusion related reaction | 95.33 | 12.13 | 5 | 53473 | 101203 | 46531381 |
Sinusitis | 94.95 | 12.13 | 17 | 53461 | 129751 | 46502833 |
Alopecia | 94.47 | 12.13 | 34 | 53444 | 162380 | 46470204 |
Device alarm issue | 93.79 | 12.13 | 41 | 53437 | 1349 | 46631235 |
Sudden onset of sleep | 93.02 | 12.13 | 33 | 53445 | 614 | 46631970 |
Joint swelling | 92.87 | 12.13 | 37 | 53441 | 166036 | 46466548 |
Embedded device | 91.38 | 12.13 | 51 | 53427 | 2865 | 46629719 |
Prescribed underdose | 90.71 | 12.13 | 89 | 53389 | 11964 | 46620620 |
Balance disorder | 89.75 | 12.13 | 216 | 53262 | 64305 | 46568279 |
Jealous delusion | 89.63 | 12.13 | 20 | 53458 | 53 | 46632531 |
Femoral neck fracture | 86.88 | 12.13 | 73 | 53405 | 8030 | 46624554 |
Pruritus | 86.56 | 12.13 | 90 | 53388 | 242262 | 46390322 |
Pleurothotonus | 83.97 | 12.13 | 36 | 53442 | 1129 | 46631455 |
Incorrect route of product administration | 82.81 | 12.13 | 98 | 53380 | 16285 | 46616299 |
Nocturia | 82.19 | 12.13 | 67 | 53411 | 7065 | 46625519 |
Stereotypy | 81.67 | 12.13 | 27 | 53451 | 402 | 46632182 |
Death | 80.82 | 12.13 | 658 | 52820 | 334890 | 46297694 |
Febrile neutropenia | 79.64 | 12.13 | 8 | 53470 | 94619 | 46537965 |
Vitamin B6 deficiency | 79.00 | 12.13 | 19 | 53459 | 77 | 46632507 |
Aggression | 78.92 | 12.13 | 113 | 53365 | 22631 | 46609953 |
Fluid intake reduced | 76.91 | 12.13 | 48 | 53430 | 3318 | 46629266 |
Agitation | 76.51 | 12.13 | 185 | 53293 | 55230 | 46577354 |
Completed suicide | 76.04 | 12.13 | 36 | 53442 | 145884 | 46486700 |
Dropped head syndrome | 74.48 | 12.13 | 19 | 53459 | 103 | 46632481 |
Neutropenia | 73.59 | 12.13 | 36 | 53442 | 143168 | 46489416 |
Toxicity to various agents | 72.97 | 12.13 | 81 | 53397 | 211685 | 46420899 |
Choking | 72.84 | 12.13 | 67 | 53411 | 8309 | 46624275 |
Injection site pain | 72.24 | 12.13 | 17 | 53461 | 107135 | 46525449 |
Weight decreased | 71.96 | 12.13 | 450 | 53028 | 210399 | 46422185 |
Maternal exposure during pregnancy | 71.70 | 12.13 | 15 | 53463 | 102534 | 46530050 |
Nasopharyngitis | 71.47 | 12.13 | 44 | 53434 | 153954 | 46478630 |
Urticaria | 71.45 | 12.13 | 23 | 53455 | 117869 | 46514715 |
Posture abnormal | 70.53 | 12.13 | 39 | 53439 | 2151 | 46630433 |
Gambling disorder | 67.75 | 12.13 | 32 | 53446 | 1264 | 46631320 |
Swelling | 67.55 | 12.13 | 29 | 53449 | 124482 | 46508102 |
Stoma site discomfort | 66.98 | 12.13 | 17 | 53461 | 90 | 46632494 |
Psychomotor hyperactivity | 66.84 | 12.13 | 68 | 53410 | 9545 | 46623039 |
Stoma complication | 66.77 | 12.13 | 20 | 53458 | 211 | 46632373 |
Nonspecific reaction | 65.28 | 12.13 | 35 | 53443 | 1815 | 46630769 |
Orthostatic intolerance | 64.99 | 12.13 | 30 | 53448 | 1124 | 46631460 |
Exposure during pregnancy | 64.02 | 12.13 | 22 | 53456 | 108190 | 46524394 |
Torticollis | 63.96 | 12.13 | 34 | 53444 | 1733 | 46630851 |
Decubitus ulcer | 63.40 | 12.13 | 67 | 53411 | 9831 | 46622753 |
Treatment failure | 62.29 | 12.13 | 15 | 53463 | 93072 | 46539512 |
Bezoar | 62.03 | 12.13 | 31 | 53447 | 1388 | 46631196 |
Thrombocytopenia | 61.80 | 12.13 | 34 | 53444 | 126547 | 46506037 |
Contraindicated product administered | 61.76 | 12.13 | 9 | 53469 | 79938 | 46552646 |
Cough | 61.36 | 12.13 | 106 | 53372 | 230143 | 46402441 |
Wrong technique in device usage process | 60.77 | 12.13 | 34 | 53444 | 1919 | 46630665 |
Acute kidney injury | 58.90 | 12.13 | 113 | 53365 | 235742 | 46396842 |
Dyspnoea | 58.00 | 12.13 | 350 | 53128 | 515198 | 46117386 |
Anxiety | 55.72 | 12.13 | 378 | 53100 | 181579 | 46451005 |
Gait inability | 55.68 | 12.13 | 124 | 53354 | 35079 | 46597505 |
Tension | 55.61 | 12.13 | 37 | 53441 | 2855 | 46629729 |
Parkinsonian gait | 55.18 | 12.13 | 21 | 53457 | 480 | 46632104 |
Hypersensitivity | 54.55 | 12.13 | 55 | 53423 | 150266 | 46482318 |
Pancytopenia | 54.43 | 12.13 | 15 | 53463 | 85043 | 46547541 |
Stoma site cellulitis | 54.28 | 12.13 | 12 | 53466 | 30 | 46632554 |
Urinary tract infection | 54.02 | 12.13 | 434 | 53044 | 219832 | 46412752 |
Nightmare | 54.00 | 12.13 | 80 | 53398 | 16518 | 46616066 |
Asthma | 53.47 | 12.13 | 19 | 53459 | 91523 | 46541061 |
Dysstasia | 53.00 | 12.13 | 82 | 53396 | 17586 | 46614998 |
Intentional medical device removal by patient | 52.71 | 12.13 | 17 | 53461 | 233 | 46632351 |
Platelet count decreased | 51.59 | 12.13 | 25 | 53453 | 99999 | 46532585 |
Stoma site abscess | 51.34 | 12.13 | 14 | 53464 | 102 | 46632482 |
Device colour issue | 51.12 | 12.13 | 11 | 53467 | 23 | 46632561 |
Pain | 50.92 | 12.13 | 329 | 53149 | 476619 | 46155965 |
Parkinsonian crisis | 50.80 | 12.13 | 11 | 53467 | 24 | 46632560 |
Drug dispensed to wrong patient | 50.04 | 12.13 | 16 | 53462 | 213 | 46632371 |
Excessive granulation tissue | 50.02 | 12.13 | 23 | 53455 | 854 | 46631730 |
Memory impairment | 49.14 | 12.13 | 197 | 53281 | 77140 | 46555444 |
Hallucination, auditory | 48.92 | 12.13 | 61 | 53417 | 10695 | 46621889 |
Device leakage | 48.77 | 12.13 | 44 | 53434 | 5321 | 46627263 |
Paranoia | 48.04 | 12.13 | 60 | 53418 | 10537 | 46622047 |
Chest pain | 48.03 | 12.13 | 80 | 53398 | 176244 | 46456340 |
Motor dysfunction | 47.90 | 12.13 | 50 | 53428 | 7232 | 46625352 |
Hypersexuality | 47.89 | 12.13 | 19 | 53459 | 487 | 46632097 |
Drug intolerance | 47.66 | 12.13 | 59 | 53419 | 146990 | 46485594 |
Off label use | 47.45 | 12.13 | 249 | 53229 | 379592 | 46252992 |
Bedridden | 46.63 | 12.13 | 55 | 53423 | 9104 | 46623480 |
Camptocormia | 46.62 | 12.13 | 15 | 53463 | 204 | 46632380 |
Movement disorder | 46.13 | 12.13 | 75 | 53403 | 16774 | 46615810 |
Stoma site oedema | 45.73 | 12.13 | 9 | 53469 | 9 | 46632575 |
Stoma site induration | 45.73 | 12.13 | 9 | 53469 | 9 | 46632575 |
Deep brain stimulation | 45.73 | 12.13 | 9 | 53469 | 9 | 46632575 |
Depressed mood | 45.72 | 12.13 | 111 | 53367 | 33208 | 46599376 |
Psoriasis | 44.75 | 12.13 | 17 | 53461 | 78587 | 46553997 |
Initial insomnia | 43.43 | 12.13 | 38 | 53440 | 4414 | 46628170 |
Hepatic enzyme increased | 42.85 | 12.13 | 20 | 53458 | 81767 | 46550817 |
Injection site erythema | 42.53 | 12.13 | 16 | 53462 | 74411 | 46558173 |
White blood cell count decreased | 41.93 | 12.13 | 40 | 53438 | 112191 | 46520393 |
Terminal state | 41.33 | 12.13 | 28 | 53450 | 2226 | 46630358 |
Apathy | 40.97 | 12.13 | 46 | 53432 | 7222 | 46625362 |
Back pain | 40.85 | 12.13 | 115 | 53363 | 209924 | 46422660 |
Malignant neoplasm progression | 40.52 | 12.13 | 12 | 53466 | 64914 | 46567670 |
Pemphigus | 40.33 | 12.13 | 3 | 53475 | 45271 | 46587313 |
Stoma site candida | 39.77 | 12.13 | 9 | 53469 | 26 | 46632558 |
Oromandibular dystonia | 39.62 | 12.13 | 16 | 53462 | 430 | 46632154 |
Musculoskeletal stiffness | 39.06 | 12.13 | 218 | 53260 | 97775 | 46534809 |
Product availability issue | 38.90 | 12.13 | 21 | 53457 | 1104 | 46631480 |
Stomatitis | 38.50 | 12.13 | 15 | 53463 | 68282 | 46564302 |
Ileus | 37.69 | 12.13 | 62 | 53416 | 14002 | 46618582 |
Loss of consciousness | 37.46 | 12.13 | 232 | 53246 | 108006 | 46524578 |
Compulsive hoarding | 36.53 | 12.13 | 10 | 53468 | 74 | 46632510 |
Dementia with Lewy bodies | 36.24 | 12.13 | 13 | 53465 | 250 | 46632334 |
Device loosening | 36.22 | 12.13 | 14 | 53464 | 334 | 46632250 |
Abortion spontaneous | 35.91 | 12.13 | 4 | 53474 | 43642 | 46588942 |
Therapeutic product effect delayed | 35.62 | 12.13 | 24 | 53454 | 1891 | 46630693 |
Altered state of consciousness | 35.53 | 12.13 | 81 | 53397 | 23267 | 46609317 |
Unintentional medical device removal | 34.97 | 12.13 | 34 | 53444 | 4519 | 46628065 |
Prescribed overdose | 34.91 | 12.13 | 51 | 53427 | 10398 | 46622186 |
Multiple system atrophy | 34.88 | 12.13 | 12 | 53466 | 203 | 46632381 |
Drooling | 34.58 | 12.13 | 29 | 53449 | 3180 | 46629404 |
Myalgia | 34.29 | 12.13 | 55 | 53423 | 123033 | 46509551 |
Erythema | 34.26 | 12.13 | 70 | 53408 | 142750 | 46489834 |
Glossodynia | 34.25 | 12.13 | 5 | 53473 | 44368 | 46588216 |
Medical device site pain | 34.14 | 12.13 | 12 | 53466 | 217 | 46632367 |
Apraxia | 33.59 | 12.13 | 22 | 53456 | 1653 | 46630931 |
Restless legs syndrome | 33.58 | 12.13 | 63 | 53415 | 15780 | 46616804 |
Herpes zoster | 33.44 | 12.13 | 18 | 53460 | 67854 | 46564730 |
Sleep talking | 33.30 | 12.13 | 18 | 53460 | 949 | 46631635 |
Oropharyngeal pain | 33.27 | 12.13 | 22 | 53456 | 74146 | 46558438 |
Fracture | 33.06 | 12.13 | 64 | 53414 | 16407 | 46616177 |
Aspiration | 32.54 | 12.13 | 47 | 53431 | 9484 | 46623100 |
Acute psychosis | 32.43 | 12.13 | 23 | 53455 | 1969 | 46630615 |
Injection site swelling | 32.42 | 12.13 | 4 | 53474 | 40323 | 46592261 |
Vitamin B12 decreased | 31.83 | 12.13 | 26 | 53452 | 2749 | 46629835 |
Injection site pruritus | 31.81 | 12.13 | 4 | 53474 | 39739 | 46592845 |
Psychotic symptom | 31.50 | 12.13 | 17 | 53461 | 893 | 46631691 |
Epilepsy | 31.41 | 12.13 | 78 | 53400 | 23660 | 46608924 |
Anaphylactic reaction | 31.05 | 12.13 | 11 | 53467 | 53101 | 46579483 |
Syncope | 31.01 | 12.13 | 216 | 53262 | 104587 | 46527997 |
Psoriatic arthropathy | 30.79 | 12.13 | 3 | 53475 | 36376 | 46596208 |
Polyneuropathy | 30.75 | 12.13 | 51 | 53427 | 11593 | 46620991 |
Device breakage | 30.50 | 12.13 | 46 | 53432 | 9646 | 46622938 |
Stoma site hypersensitivity | 30.49 | 12.13 | 6 | 53472 | 6 | 46632578 |
Cerebral atrophy | 30.34 | 12.13 | 32 | 53446 | 4684 | 46627900 |
Abdominal discomfort | 29.94 | 12.13 | 82 | 53396 | 151083 | 46481501 |
Product prescribing error | 29.90 | 12.13 | 69 | 53409 | 19978 | 46612606 |
Euthanasia | 29.80 | 12.13 | 7 | 53471 | 25 | 46632559 |
Pelvic fracture | 29.75 | 12.13 | 50 | 53428 | 11489 | 46621095 |
Upper respiratory tract infection | 29.68 | 12.13 | 18 | 53460 | 63538 | 46569046 |
Product administration error | 29.64 | 12.13 | 68 | 53410 | 19613 | 46612971 |
Injection site reaction | 29.57 | 12.13 | 9 | 53469 | 47840 | 46584744 |
Illusion | 29.14 | 12.13 | 17 | 53461 | 1039 | 46631545 |
Medical device change | 29.03 | 12.13 | 12 | 53466 | 343 | 46632241 |
Device physical property issue | 28.98 | 12.13 | 19 | 53459 | 1430 | 46631154 |
Migraine | 28.51 | 12.13 | 23 | 53455 | 70003 | 46562581 |
Pyrexia | 28.46 | 12.13 | 259 | 53219 | 348543 | 46284041 |
Suspiciousness | 28.45 | 12.13 | 12 | 53466 | 361 | 46632223 |
Injection site bruising | 27.54 | 12.13 | 4 | 53474 | 35632 | 46596952 |
Enteral nutrition | 27.43 | 12.13 | 7 | 53471 | 38 | 46632546 |
Arthropathy | 27.41 | 12.13 | 34 | 53444 | 84666 | 46547918 |
Resting tremor | 27.23 | 12.13 | 14 | 53464 | 666 | 46631918 |
Fatigue | 27.15 | 12.13 | 513 | 52965 | 608184 | 46024400 |
Neutrophil count decreased | 27.14 | 12.13 | 8 | 53470 | 43418 | 46589166 |
Helplessness | 27.02 | 12.13 | 10 | 53468 | 211 | 46632373 |
Depressed level of consciousness | 26.93 | 12.13 | 117 | 53361 | 47452 | 46585132 |
Extra dose administered | 26.89 | 12.13 | 30 | 53448 | 4677 | 46627907 |
Femur fracture | 26.56 | 12.13 | 98 | 53380 | 36899 | 46595685 |
Gastrostomy | 26.43 | 12.13 | 13 | 53465 | 562 | 46632022 |
Nasal congestion | 26.40 | 12.13 | 11 | 53467 | 48102 | 46584482 |
Hallucinations, mixed | 26.34 | 12.13 | 27 | 53451 | 3822 | 46628762 |
Catecholamines urine increased | 26.34 | 12.13 | 6 | 53472 | 18 | 46632566 |
Aphasia | 26.07 | 12.13 | 82 | 53396 | 28485 | 46604099 |
Device placement issue | 25.77 | 12.13 | 11 | 53467 | 341 | 46632243 |
Drug interaction | 25.72 | 12.13 | 350 | 53128 | 202744 | 46429840 |
Hyperventilation | 25.64 | 12.13 | 32 | 53446 | 5615 | 46626969 |
Anaemia | 25.42 | 12.13 | 180 | 53298 | 255599 | 46376985 |
Medical device site ulcer | 25.41 | 12.13 | 5 | 53473 | 5 | 46632579 |
Stoma site rash | 25.41 | 12.13 | 5 | 53473 | 5 | 46632579 |
Medical device site injury | 25.41 | 12.13 | 5 | 53473 | 5 | 46632579 |
Gastrointestinal complication associated with device | 25.41 | 12.13 | 5 | 53473 | 5 | 46632579 |
Lymphadenopathy | 25.33 | 12.13 | 4 | 53474 | 33484 | 46599100 |
Peritonitis | 25.26 | 12.13 | 66 | 53412 | 20648 | 46611936 |
Abnormal faeces | 25.20 | 12.13 | 27 | 53451 | 4022 | 46628562 |
Alanine aminotransferase increased | 25.12 | 12.13 | 39 | 53439 | 88412 | 46544172 |
Intussusception | 25.10 | 12.13 | 12 | 53466 | 487 | 46632097 |
Epistaxis | 25.10 | 12.13 | 22 | 53456 | 64283 | 46568301 |
Wrong technique in product usage process | 25.04 | 12.13 | 126 | 53352 | 54296 | 46578288 |
Liver function test abnormal | 24.92 | 12.13 | 11 | 53467 | 46476 | 46586108 |
Middle insomnia | 24.23 | 12.13 | 41 | 53437 | 9474 | 46623110 |
Interstitial lung disease | 24.20 | 12.13 | 16 | 53462 | 53933 | 46578651 |
Medical device site hyperaesthesia | 24.10 | 12.13 | 5 | 53473 | 8 | 46632576 |
Salivary hypersecretion | 23.80 | 12.13 | 33 | 53445 | 6412 | 46626172 |
Radioisotope scan abnormal | 23.76 | 12.13 | 9 | 53469 | 203 | 46632381 |
Head injury | 23.68 | 12.13 | 72 | 53406 | 24564 | 46608020 |
Chest discomfort | 23.60 | 12.13 | 42 | 53436 | 90227 | 46542357 |
COVID-19 | 23.49 | 12.13 | 60 | 53418 | 18515 | 46614069 |
Feeding disorder | 23.45 | 12.13 | 42 | 53436 | 10152 | 46622432 |
Decreased appetite | 23.31 | 12.13 | 331 | 53147 | 193505 | 46439079 |
Poor quality sleep | 23.30 | 12.13 | 53 | 53425 | 15200 | 46617384 |
Faecaloma | 23.28 | 12.13 | 36 | 53442 | 7716 | 46624868 |
Heart rate increased | 23.19 | 12.13 | 31 | 53447 | 74760 | 46557824 |
Bradyphrenia | 23.16 | 12.13 | 32 | 53446 | 6198 | 46626386 |
Disturbance in attention | 22.99 | 12.13 | 84 | 53394 | 31476 | 46601108 |
Mental disorder | 22.94 | 12.13 | 67 | 53411 | 22358 | 46610226 |
General physical condition abnormal | 22.80 | 12.13 | 24 | 53454 | 3504 | 46629080 |
Oedema | 22.68 | 12.13 | 26 | 53452 | 67045 | 46565539 |
Wheezing | 22.41 | 12.13 | 17 | 53461 | 53369 | 46579215 |
Hand deformity | 22.29 | 12.13 | 6 | 53472 | 34568 | 46598016 |
Bone pain | 22.28 | 12.13 | 13 | 53465 | 46877 | 46585707 |
Rapid eye movement sleep behaviour disorder | 22.15 | 12.13 | 8 | 53470 | 157 | 46632427 |
Bronchitis | 22.11 | 12.13 | 56 | 53422 | 105923 | 46526661 |
Behaviour disorder | 21.71 | 12.13 | 18 | 53460 | 1943 | 46630641 |
Plasma cell myeloma | 21.61 | 12.13 | 12 | 53466 | 44466 | 46588118 |
Rhinorrhoea | 21.56 | 12.13 | 14 | 53464 | 47651 | 46584933 |
Medical device site erosion | 21.48 | 12.13 | 5 | 53473 | 17 | 46632567 |
Lower respiratory tract infection | 21.32 | 12.13 | 19 | 53459 | 55070 | 46577514 |
Emotional disorder | 21.29 | 12.13 | 45 | 53433 | 12279 | 46620305 |
Sopor | 21.01 | 12.13 | 60 | 53418 | 19768 | 46612816 |
Eczema eyelids | 21.00 | 12.13 | 7 | 53471 | 107 | 46632477 |
Clavicle fracture | 20.87 | 12.13 | 21 | 53457 | 2908 | 46629676 |
Therapeutic product effect incomplete | 20.76 | 12.13 | 157 | 53321 | 77996 | 46554588 |
Vascular encephalopathy | 20.69 | 12.13 | 10 | 53468 | 416 | 46632168 |
Chorea | 20.52 | 12.13 | 14 | 53464 | 1126 | 46631458 |
Nausea | 20.47 | 12.13 | 616 | 52862 | 686838 | 45945746 |
Extrapyramidal disorder | 20.47 | 12.13 | 42 | 53436 | 11226 | 46621358 |
Medical device site dryness | 20.32 | 12.13 | 4 | 53474 | 4 | 46632580 |
Osteonecrosis of jaw | 20.32 | 12.13 | 7 | 53471 | 34395 | 46598189 |
Hypertension | 20.07 | 12.13 | 137 | 53341 | 196219 | 46436365 |
Cachexia | 19.90 | 12.13 | 26 | 53452 | 4773 | 46627811 |
Product use issue | 19.75 | 12.13 | 50 | 53428 | 94594 | 46537990 |
Breast cancer | 19.75 | 12.13 | 14 | 53464 | 45504 | 46587080 |
Swelling face | 19.70 | 12.13 | 19 | 53459 | 53040 | 46579544 |
Mucosal inflammation | 19.70 | 12.13 | 10 | 53468 | 38966 | 46593618 |
Hallucination, tactile | 19.54 | 12.13 | 8 | 53470 | 223 | 46632361 |
Leukopenia | 19.53 | 12.13 | 30 | 53448 | 68313 | 46564271 |
Vaginal haemorrhage | 19.50 | 12.13 | 3 | 53475 | 25601 | 46606983 |
Arthritis | 19.30 | 12.13 | 37 | 53441 | 77279 | 46555305 |
Obsessive-compulsive disorder | 19.24 | 12.13 | 21 | 53457 | 3194 | 46629390 |
Limbic encephalitis | 19.24 | 12.13 | 8 | 53470 | 232 | 46632352 |
Eating disorder | 19.23 | 12.13 | 48 | 53430 | 14606 | 46617978 |
Upper limb fracture | 19.09 | 12.13 | 50 | 53428 | 15663 | 46616921 |
Impulsive behaviour | 19.09 | 12.13 | 15 | 53463 | 1500 | 46631084 |
Diet refusal | 19.07 | 12.13 | 11 | 53467 | 658 | 46631926 |
Intentional overdose | 19.05 | 12.13 | 28 | 53450 | 64916 | 46567668 |
Fibromyalgia | 18.96 | 12.13 | 9 | 53469 | 36454 | 46596130 |
Faeces hard | 18.76 | 12.13 | 14 | 53464 | 1297 | 46631287 |
Influenza like illness | 18.74 | 12.13 | 23 | 53455 | 57547 | 46575037 |
Wheelchair user | 18.66 | 12.13 | 23 | 53455 | 3985 | 46628599 |
Dyschezia | 18.63 | 12.13 | 15 | 53463 | 1553 | 46631031 |
Disease progression | 18.46 | 12.13 | 49 | 53429 | 91251 | 46541333 |
Neoplasm progression | 18.44 | 12.13 | 4 | 53474 | 26679 | 46605905 |
Weight increased | 18.21 | 12.13 | 112 | 53366 | 164361 | 46468223 |
Incontinence | 18.20 | 12.13 | 37 | 53441 | 9825 | 46622759 |
Viral infection | 18.12 | 12.13 | 6 | 53472 | 30229 | 46602355 |
Gastrostomy tube site complication | 18.09 | 12.13 | 4 | 53474 | 10 | 46632574 |
Granuloma | 18.01 | 12.13 | 22 | 53456 | 3776 | 46628808 |
Sputum retention | 17.76 | 12.13 | 9 | 53469 | 415 | 46632169 |
Immobile | 17.64 | 12.13 | 24 | 53454 | 4582 | 46628002 |
Hyponatraemic syndrome | 17.59 | 12.13 | 10 | 53468 | 582 | 46632002 |
Rash pruritic | 17.41 | 12.13 | 15 | 53463 | 44200 | 46588384 |
Renal impairment | 17.36 | 12.13 | 37 | 53441 | 74335 | 46558249 |
Postural reflex impairment | 17.32 | 12.13 | 3 | 53475 | 0 | 46632584 |
Cellulitis | 17.22 | 12.13 | 34 | 53444 | 70254 | 46562330 |
Transient aphasia | 17.02 | 12.13 | 5 | 53473 | 49 | 46632535 |
Dairy intolerance | 17.02 | 12.13 | 5 | 53473 | 49 | 46632535 |
Aspartate aminotransferase increased | 16.87 | 12.13 | 41 | 53437 | 78659 | 46553925 |
Red blood cell sedimentation rate increased | 16.72 | 12.13 | 3 | 53475 | 22886 | 46609698 |
Pyramidal tract syndrome | 16.71 | 12.13 | 8 | 53470 | 326 | 46632258 |
Tarsal tunnel syndrome | 16.65 | 12.13 | 10 | 53468 | 645 | 46631939 |
Gastric perforation | 16.64 | 12.13 | 13 | 53465 | 1289 | 46631295 |
Incoherent | 16.51 | 12.13 | 23 | 53455 | 4489 | 46628095 |
Influenza | 16.51 | 12.13 | 50 | 53428 | 89220 | 46543364 |
Wrist fracture | 16.50 | 12.13 | 39 | 53439 | 11464 | 46621120 |
Serotonin syndrome | 16.42 | 12.13 | 63 | 53415 | 24157 | 46608427 |
Pain in jaw | 16.39 | 12.13 | 12 | 53466 | 38360 | 46594224 |
Constipation | 16.25 | 12.13 | 285 | 53193 | 173812 | 46458772 |
Infrequent bowel movements | 16.23 | 12.13 | 12 | 53466 | 1096 | 46631488 |
Chills | 16.22 | 12.13 | 56 | 53422 | 95976 | 46536608 |
Locked-in syndrome | 16.20 | 12.13 | 8 | 53470 | 349 | 46632235 |
Neuropathy peripheral | 16.04 | 12.13 | 52 | 53426 | 90841 | 46541743 |
Bone marrow failure | 15.93 | 12.13 | 7 | 53471 | 29662 | 46602922 |
Cerebellar haematoma | 15.85 | 12.13 | 8 | 53470 | 366 | 46632218 |
Gastrooesophageal reflux disease | 15.72 | 12.13 | 39 | 53439 | 74305 | 46558279 |
Pericarditis | 15.72 | 12.13 | 4 | 53474 | 23923 | 46608661 |
Medical device site scab | 15.63 | 12.13 | 4 | 53474 | 22 | 46632562 |
Progressive supranuclear palsy | 15.54 | 12.13 | 5 | 53473 | 68 | 46632516 |
Inhibitory drug interaction | 15.51 | 12.13 | 15 | 53463 | 1980 | 46630604 |
Rehabilitation therapy | 15.45 | 12.13 | 12 | 53466 | 1180 | 46631404 |
Urge incontinence | 15.32 | 12.13 | 10 | 53468 | 747 | 46631837 |
Deep vein thrombosis | 15.24 | 12.13 | 44 | 53434 | 79729 | 46552855 |
Medical device site abscess | 15.24 | 12.13 | 3 | 53475 | 3 | 46632581 |
Medical device site discolouration | 15.24 | 12.13 | 3 | 53475 | 3 | 46632581 |
Medical device site vesicles | 15.24 | 12.13 | 3 | 53475 | 3 | 46632581 |
Sedative therapy | 15.24 | 12.13 | 3 | 53475 | 3 | 46632581 |
Propulsive gait | 15.24 | 12.13 | 3 | 53475 | 3 | 46632581 |
Medication error | 15.24 | 12.13 | 73 | 53405 | 30838 | 46601746 |
Pregnancy | 15.22 | 12.13 | 6 | 53472 | 27131 | 46605453 |
Flushing | 15.20 | 12.13 | 32 | 53446 | 64582 | 46568002 |
Nuchal rigidity | 15.18 | 12.13 | 9 | 53469 | 567 | 46632017 |
Unresponsive to stimuli | 15.16 | 12.13 | 75 | 53403 | 32099 | 46600485 |
Product use in unapproved indication | 15.01 | 12.13 | 53 | 53425 | 90220 | 46542364 |
Dry eye | 14.99 | 12.13 | 8 | 53470 | 30314 | 46602270 |
Supine hypertension | 14.97 | 12.13 | 5 | 53473 | 77 | 46632507 |
Mouth ulceration | 14.94 | 12.13 | 6 | 53472 | 26826 | 46605758 |
Hepatotoxicity | 14.92 | 12.13 | 5 | 53473 | 25004 | 46607580 |
Device difficult to use | 14.74 | 12.13 | 30 | 53448 | 7974 | 46624610 |
Multiple sclerosis | 14.72 | 12.13 | 5 | 53473 | 24786 | 46607798 |
Gastrointestinal stoma complication | 14.58 | 12.13 | 13 | 53465 | 1548 | 46631036 |
Heat stroke | 14.54 | 12.13 | 9 | 53469 | 613 | 46631971 |
Purpura senile | 14.37 | 12.13 | 9 | 53469 | 626 | 46631958 |
Screaming | 14.35 | 12.13 | 18 | 53460 | 3173 | 46629411 |
Respiratory dyskinesia | 14.34 | 12.13 | 4 | 53474 | 32 | 46632552 |
Saliva altered | 14.27 | 12.13 | 7 | 53471 | 301 | 46632283 |
Unevaluable event | 14.13 | 12.13 | 96 | 53382 | 46079 | 46586505 |
Pulmonary arterial hypertension | 14.11 | 12.13 | 6 | 53472 | 25922 | 46606662 |
Persecutory delusion | 14.11 | 12.13 | 16 | 53462 | 2539 | 46630045 |
Vitamin B6 decreased | 14.03 | 12.13 | 3 | 53475 | 6 | 46632578 |
Vaccination site oedema | 14.02 | 12.13 | 4 | 53474 | 35 | 46632549 |
Vestibular disorder | 14.01 | 12.13 | 12 | 53466 | 1354 | 46631230 |
Fear of falling | 14.00 | 12.13 | 6 | 53472 | 188 | 46632396 |
Vaccination site bruising | 13.92 | 12.13 | 4 | 53474 | 36 | 46632548 |
Vaccination site pruritus | 13.92 | 12.13 | 4 | 53474 | 36 | 46632548 |
Pulmonary fibrosis | 13.91 | 12.13 | 3 | 53475 | 20089 | 46612495 |
Hepatic failure | 13.57 | 12.13 | 11 | 53467 | 33405 | 46599179 |
Sleep disorder | 13.56 | 12.13 | 96 | 53382 | 46699 | 46585885 |
Multiple sclerosis relapse | 13.53 | 12.13 | 17 | 53461 | 42108 | 46590476 |
Catatonia | 13.50 | 12.13 | 19 | 53459 | 3743 | 46628841 |
Dyspnoea exertional | 13.50 | 12.13 | 23 | 53455 | 50266 | 46582318 |
Listless | 13.43 | 12.13 | 14 | 53464 | 2021 | 46630563 |
Device use issue | 13.43 | 12.13 | 12 | 53466 | 1433 | 46631151 |
Diabetes mellitus | 13.35 | 12.13 | 23 | 53455 | 50042 | 46582542 |
Immune-mediated adverse reaction | 13.22 | 12.13 | 6 | 53472 | 216 | 46632368 |
Impaired self-care | 13.20 | 12.13 | 13 | 53465 | 1755 | 46630829 |
Delusion of parasitosis | 13.17 | 12.13 | 3 | 53475 | 9 | 46632575 |
Cogwheel rigidity | 13.11 | 12.13 | 12 | 53466 | 1478 | 46631106 |
Autonomic nervous system imbalance | 13.07 | 12.13 | 15 | 53463 | 2411 | 46630173 |
Communication disorder | 13.04 | 12.13 | 15 | 53463 | 2418 | 46630166 |
Hypernatraemia | 13 | 12.13 | 25 | 53453 | 6376 | 46626208 |
Blood bilirubin increased | 12.97 | 12.13 | 12 | 53466 | 34172 | 46598412 |
Mixed dementia | 12.93 | 12.13 | 3 | 53475 | 10 | 46632574 |
Hypersomnia | 12.90 | 12.13 | 43 | 53435 | 15396 | 46617188 |
Rash maculo-papular | 12.86 | 12.13 | 8 | 53470 | 27866 | 46604718 |
Blood glucose increased | 12.84 | 12.13 | 41 | 53437 | 71972 | 46560612 |
Acute abdomen | 12.83 | 12.13 | 12 | 53466 | 1520 | 46631064 |
Haemoptysis | 12.82 | 12.13 | 7 | 53471 | 26182 | 46606402 |
Mini mental status examination abnormal | 12.71 | 12.13 | 3 | 53475 | 11 | 46632573 |
Tongue necrosis | 12.71 | 12.13 | 3 | 53475 | 11 | 46632573 |
Wrong product administered | 12.70 | 12.13 | 23 | 53455 | 5607 | 46626977 |
Cardiac failure congestive | 12.64 | 12.13 | 58 | 53420 | 91692 | 46540892 |
Foetal exposure during pregnancy | 12.64 | 12.13 | 10 | 53468 | 30737 | 46601847 |
Injection site haemorrhage | 12.61 | 12.13 | 4 | 53474 | 20705 | 46611879 |
Device deposit issue | 12.51 | 12.13 | 3 | 53475 | 12 | 46632572 |
Feeling abnormal | 12.49 | 12.13 | 207 | 53271 | 124853 | 46507731 |
Osteoporosis | 12.41 | 12.13 | 17 | 53461 | 40591 | 46591993 |
Hyperthermia | 12.41 | 12.13 | 28 | 53450 | 7986 | 46624598 |
Pain in extremity | 12.41 | 12.13 | 215 | 53263 | 258465 | 46374119 |
Product dose omission issue | 12.37 | 12.13 | 266 | 53212 | 168254 | 46464330 |
Normochromic normocytic anaemia | 12.37 | 12.13 | 20 | 53458 | 4452 | 46628132 |
Night sweats | 12.33 | 12.13 | 8 | 53470 | 27242 | 46605342 |
Psychiatric symptom | 12.28 | 12.13 | 20 | 53458 | 4477 | 46628107 |
Abdominal rigidity | 12.24 | 12.13 | 12 | 53466 | 1610 | 46630974 |
Labelled drug-drug interaction medication error | 12.23 | 12.13 | 30 | 53448 | 9031 | 46623553 |
Ear pain | 12.20 | 12.13 | 5 | 53473 | 22087 | 46610497 |
Anaphylactic shock | 12.19 | 12.13 | 4 | 53474 | 20270 | 46612314 |
Urine calcium/creatinine ratio increased | 12.19 | 12.13 | 5 | 53473 | 140 | 46632444 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hallucination | 2402.24 | 13.28 | 1430 | 63688 | 47629 | 29839731 |
On and off phenomenon | 1873.30 | 13.28 | 540 | 64578 | 2351 | 29885009 |
Dyskinesia | 1713.03 | 13.28 | 870 | 64248 | 20964 | 29866396 |
Device dislocation | 1268.69 | 13.28 | 459 | 64659 | 4572 | 29882788 |
Freezing phenomenon | 1251.24 | 13.28 | 361 | 64757 | 1575 | 29885785 |
Fall | 1126.50 | 13.28 | 1658 | 63460 | 180214 | 29707146 |
Stoma site discharge | 1096.57 | 13.28 | 308 | 64810 | 1193 | 29886167 |
Stoma site erythema | 830.29 | 13.28 | 229 | 64889 | 815 | 29886545 |
Embedded device | 645.95 | 13.28 | 164 | 64954 | 381 | 29886979 |
Hyperkinesia | 583.80 | 13.28 | 206 | 64912 | 1892 | 29885468 |
Stoma site infection | 573.08 | 13.28 | 168 | 64950 | 783 | 29886577 |
Hallucination, visual | 552.31 | 13.28 | 376 | 64742 | 15737 | 29871623 |
Muscle rigidity | 544.63 | 13.28 | 316 | 64802 | 9945 | 29877415 |
Confusional state | 519.18 | 13.28 | 996 | 64122 | 133838 | 29753522 |
Bradykinesia | 477.16 | 13.28 | 200 | 64918 | 3030 | 29884330 |
Delusion | 474.35 | 13.28 | 306 | 64812 | 11683 | 29875677 |
Device occlusion | 456.35 | 13.28 | 236 | 64882 | 5884 | 29881476 |
Stoma site pain | 455.44 | 13.28 | 132 | 64986 | 586 | 29886774 |
Akinesia | 441.72 | 13.28 | 176 | 64942 | 2324 | 29885036 |
Dopamine dysregulation syndrome | 429.92 | 13.28 | 118 | 65000 | 410 | 29886950 |
Device issue | 426.17 | 13.28 | 245 | 64873 | 7571 | 29879789 |
General physical health deterioration | 416.22 | 13.28 | 764 | 64354 | 99180 | 29788180 |
Mobility decreased | 412.94 | 13.28 | 386 | 64732 | 25613 | 29861747 |
Stoma site inflammation | 398.89 | 13.28 | 115 | 65003 | 499 | 29886861 |
Hypersexuality | 390.94 | 13.28 | 140 | 64978 | 1347 | 29886013 |
Dysphagia | 388.26 | 13.28 | 544 | 64574 | 56154 | 29831206 |
Gait disturbance | 376.82 | 13.28 | 622 | 64496 | 74155 | 29813205 |
Dementia | 369.15 | 13.28 | 266 | 64852 | 12195 | 29875165 |
Impulse-control disorder | 361.70 | 13.28 | 130 | 64988 | 1265 | 29886095 |
Stoma site hypergranulation | 337.67 | 13.28 | 89 | 65029 | 253 | 29887107 |
Gambling disorder | 323.20 | 13.28 | 129 | 64989 | 1711 | 29885649 |
Pneumonia aspiration | 312.98 | 13.28 | 398 | 64720 | 37382 | 29849978 |
Tremor | 304.50 | 13.28 | 569 | 64549 | 74794 | 29812566 |
Intentional medical device removal by patient | 278.00 | 13.28 | 76 | 65042 | 259 | 29887101 |
Aggression | 271.85 | 13.28 | 367 | 64751 | 36540 | 29850820 |
Cognitive disorder | 271.83 | 13.28 | 295 | 64823 | 23395 | 29863965 |
Device kink | 254.00 | 13.28 | 80 | 65038 | 495 | 29886865 |
Abnormal behaviour | 251.21 | 13.28 | 294 | 64824 | 25329 | 29862031 |
Stoma site haemorrhage | 246.69 | 13.28 | 88 | 65030 | 836 | 29886524 |
Device connection issue | 239.45 | 13.28 | 74 | 65044 | 426 | 29886934 |
Stoma site reaction | 210.96 | 13.28 | 58 | 65060 | 203 | 29887157 |
Restlessness | 202.93 | 13.28 | 248 | 64870 | 22351 | 29865009 |
Fibroma | 202.02 | 13.28 | 58 | 65060 | 247 | 29887113 |
Device alarm issue | 199.81 | 13.28 | 72 | 65046 | 706 | 29886654 |
Dystonia | 197.35 | 13.28 | 166 | 64952 | 9561 | 29877799 |
Somnolence | 192.75 | 13.28 | 553 | 64565 | 96210 | 29791150 |
Toxicity to various agents | 191.53 | 13.28 | 73 | 65045 | 177110 | 29710250 |
Febrile neutropenia | 190.90 | 13.28 | 10 | 65108 | 106683 | 29780677 |
Parkinson's disease | 187.06 | 13.28 | 86 | 65032 | 1642 | 29885718 |
Balance disorder | 184.10 | 13.28 | 304 | 64814 | 36189 | 29851171 |
Stoma site extravasation | 180.04 | 13.28 | 47 | 65071 | 127 | 29887233 |
Therapeutic product effect variable | 178.68 | 13.28 | 78 | 65040 | 1311 | 29886049 |
Abnormal dreams | 176.10 | 13.28 | 144 | 64974 | 7971 | 29879389 |
Diarrhoea | 165.17 | 13.28 | 297 | 64821 | 333806 | 29553554 |
Agitation | 163.17 | 13.28 | 362 | 64756 | 53711 | 29833649 |
Prescribed underdose | 162.75 | 13.28 | 135 | 64983 | 7624 | 29879736 |
Orthostatic hypotension | 154.92 | 13.28 | 224 | 64894 | 23755 | 29863605 |
Hypokinesia | 149.54 | 13.28 | 125 | 64993 | 7135 | 29880225 |
Psychotic disorder | 149.35 | 13.28 | 208 | 64910 | 21307 | 29866053 |
Urinary tract infection | 148.55 | 13.28 | 423 | 64695 | 73236 | 29814124 |
Speech disorder | 148.29 | 13.28 | 222 | 64896 | 24290 | 29863070 |
Hip fracture | 140.79 | 13.28 | 146 | 64972 | 10978 | 29876382 |
Underdose | 140.62 | 13.28 | 152 | 64966 | 11989 | 29875371 |
Neutropenia | 138.73 | 13.28 | 53 | 65065 | 128487 | 29758873 |
Rash | 131.62 | 13.28 | 134 | 64984 | 191755 | 29695605 |
Stoma site irritation | 131.16 | 13.28 | 36 | 65082 | 125 | 29887235 |
Unintentional medical device removal | 130.20 | 13.28 | 72 | 65046 | 2059 | 29885301 |
Incorrect route of product administration | 129.90 | 13.28 | 141 | 64977 | 11174 | 29876186 |
Acute kidney injury | 129.35 | 13.28 | 250 | 64868 | 273592 | 29613768 |
Platelet count decreased | 128.14 | 13.28 | 36 | 65082 | 106093 | 29781267 |
Posture abnormal | 127.86 | 13.28 | 68 | 65050 | 1796 | 29885564 |
Wrong technique in device usage process | 127.54 | 13.28 | 55 | 65063 | 896 | 29886464 |
Nonspecific reaction | 125.91 | 13.28 | 60 | 65058 | 1246 | 29886114 |
Stoma site odour | 120.20 | 13.28 | 30 | 65088 | 63 | 29887297 |
Parkinsonism | 119.30 | 13.28 | 110 | 65008 | 7159 | 29880201 |
Device breakage | 116.51 | 13.28 | 61 | 65057 | 1559 | 29885801 |
Jealous delusion | 116.51 | 13.28 | 37 | 65081 | 236 | 29887124 |
Parkinsonism hyperpyrexia syndrome | 116.12 | 13.28 | 31 | 65087 | 94 | 29887266 |
Musculoskeletal stiffness | 115.92 | 13.28 | 247 | 64871 | 35634 | 29851726 |
Memory impairment | 115.63 | 13.28 | 252 | 64866 | 36922 | 29850438 |
Decubitus ulcer | 114.72 | 13.28 | 111 | 65007 | 7677 | 29879683 |
Pancytopenia | 114.17 | 13.28 | 23 | 65095 | 85029 | 29802331 |
Gait inability | 113.03 | 13.28 | 170 | 64948 | 18671 | 29868689 |
Thrombocytopenia | 111.80 | 13.28 | 81 | 65037 | 136963 | 29750397 |
Dysstasia | 108.71 | 13.28 | 124 | 64994 | 10381 | 29876979 |
Reduced facial expression | 107.53 | 13.28 | 46 | 65072 | 734 | 29886626 |
Malignant neoplasm progression | 107.07 | 13.28 | 15 | 65103 | 72272 | 29815088 |
Deep brain stimulation | 106.95 | 13.28 | 25 | 65093 | 34 | 29887326 |
Alanine aminotransferase increased | 104.15 | 13.28 | 18 | 65100 | 74258 | 29813102 |
Death | 102.31 | 13.28 | 1205 | 63913 | 356078 | 29531282 |
Compulsive shopping | 102.22 | 13.28 | 38 | 65080 | 410 | 29886950 |
Delirium | 101.77 | 13.28 | 253 | 64865 | 40378 | 29846982 |
Disorientation | 101.16 | 13.28 | 216 | 64902 | 31202 | 29856158 |
Pruritus | 100.19 | 13.28 | 67 | 65051 | 118137 | 29769223 |
Therapeutic response shortened | 100.10 | 13.28 | 74 | 65044 | 3526 | 29883834 |
Dyspnoea | 97.03 | 13.28 | 385 | 64733 | 332910 | 29554450 |
Nightmare | 96.39 | 13.28 | 125 | 64993 | 11951 | 29875409 |
Poor quality sleep | 95.17 | 13.28 | 97 | 65021 | 7144 | 29880216 |
Device deployment issue | 93.49 | 13.28 | 26 | 65092 | 96 | 29887264 |
Paranoia | 93.36 | 13.28 | 113 | 65005 | 10075 | 29877285 |
Device difficult to use | 91.26 | 13.28 | 38 | 65080 | 565 | 29886795 |
Prescribed overdose | 88.49 | 13.28 | 101 | 65017 | 8460 | 29878900 |
Headache | 86.28 | 13.28 | 166 | 64952 | 182140 | 29705220 |
Bedridden | 85.52 | 13.28 | 68 | 65050 | 3614 | 29883746 |
Arthralgia | 85.10 | 13.28 | 102 | 65016 | 135689 | 29751671 |
Tension | 81.39 | 13.28 | 48 | 65070 | 1555 | 29885805 |
Choking | 79.52 | 13.28 | 74 | 65044 | 4872 | 29882488 |
Completed suicide | 78.27 | 13.28 | 61 | 65057 | 99431 | 29787929 |
Aspartate aminotransferase increased | 77.47 | 13.28 | 21 | 65097 | 63401 | 29823959 |
Device leakage | 76.89 | 13.28 | 64 | 65054 | 3630 | 29883730 |
Stoma site discomfort | 76.89 | 13.28 | 20 | 65098 | 53 | 29887307 |
Device expulsion | 76.05 | 13.28 | 21 | 65097 | 75 | 29887285 |
Infusion related reaction | 75.10 | 13.28 | 3 | 65115 | 40561 | 29846799 |
Sleep talking | 74.75 | 13.28 | 31 | 65087 | 456 | 29886904 |
Drug hypersensitivity | 74.27 | 13.28 | 28 | 65090 | 68491 | 29818869 |
Stoma site induration | 73.70 | 13.28 | 19 | 65099 | 48 | 29887312 |
Neuroleptic malignant syndrome | 73.21 | 13.28 | 129 | 64989 | 16166 | 29871194 |
Aspiration | 71.70 | 13.28 | 101 | 65017 | 10450 | 29876910 |
Excessive granulation tissue | 71.27 | 13.28 | 30 | 65088 | 459 | 29886901 |
Rheumatoid arthritis | 70.19 | 13.28 | 5 | 65113 | 41192 | 29846168 |
Bezoar | 70.10 | 13.28 | 36 | 65082 | 883 | 29886477 |
Hyperkalaemia | 69.85 | 13.28 | 28 | 65090 | 65982 | 29821378 |
Anaemia | 69.14 | 13.28 | 227 | 64891 | 207765 | 29679595 |
Parkinsonian gait | 69.00 | 13.28 | 29 | 65089 | 442 | 29886918 |
Drooling | 68.73 | 13.28 | 55 | 65063 | 2950 | 29884410 |
Renal failure | 68.62 | 13.28 | 109 | 65009 | 128857 | 29758503 |
Cogwheel rigidity | 68.35 | 13.28 | 38 | 65080 | 1098 | 29886262 |
Device physical property issue | 68.15 | 13.28 | 32 | 65086 | 642 | 29886718 |
Movement disorder | 67.74 | 13.28 | 95 | 65023 | 9788 | 29877572 |
Hypophagia | 67.14 | 13.28 | 149 | 64969 | 22087 | 29865273 |
Plasma cell myeloma | 66.63 | 13.28 | 17 | 65101 | 53445 | 29833915 |
White blood cell count decreased | 66.62 | 13.28 | 51 | 65067 | 83896 | 29803464 |
Nocturia | 66.27 | 13.28 | 86 | 65032 | 8226 | 29879134 |
Pyrexia | 65.73 | 13.28 | 374 | 64744 | 294115 | 29593245 |
Urticaria | 64.98 | 13.28 | 19 | 65099 | 54587 | 29832773 |
Stereotypy | 64.77 | 13.28 | 29 | 65089 | 519 | 29886841 |
Foetal exposure during pregnancy | 64.21 | 13.28 | 4 | 65114 | 36867 | 29850493 |
Nausea | 64.21 | 13.28 | 381 | 64737 | 296576 | 29590784 |
Myalgia | 64.19 | 13.28 | 44 | 65074 | 76623 | 29810737 |
Device use issue | 63.50 | 13.28 | 21 | 65097 | 155 | 29887205 |
Psoriasis | 62.50 | 13.28 | 9 | 65109 | 42497 | 29844863 |
Psychomotor hyperactivity | 60.80 | 13.28 | 82 | 65036 | 8142 | 29879218 |
Sudden onset of sleep | 59.99 | 13.28 | 26 | 65092 | 429 | 29886931 |
Renal impairment | 59.65 | 13.28 | 57 | 65061 | 84127 | 29803233 |
Intentional device misuse | 59.62 | 13.28 | 22 | 65096 | 232 | 29887128 |
Stomatitis | 59.47 | 13.28 | 6 | 65112 | 37273 | 29850087 |
Femoral neck fracture | 59.23 | 13.28 | 50 | 65068 | 2892 | 29884468 |
Motor dysfunction | 58.25 | 13.28 | 68 | 65050 | 5834 | 29881526 |
Hypersomnia | 57.99 | 13.28 | 95 | 65023 | 11221 | 29876139 |
Gambling | 57.90 | 13.28 | 21 | 65097 | 210 | 29887150 |
Middle insomnia | 57.79 | 13.28 | 67 | 65051 | 5706 | 29881654 |
Leukopenia | 57.52 | 13.28 | 25 | 65093 | 56134 | 29831226 |
Resting tremor | 56.91 | 13.28 | 27 | 65091 | 555 | 29886805 |
Feeling abnormal | 56.57 | 13.28 | 259 | 64859 | 56497 | 29830863 |
Stoma site ulcer | 56.06 | 13.28 | 15 | 65103 | 46 | 29887314 |
Blood creatinine increased | 55.77 | 13.28 | 70 | 65048 | 91305 | 29796055 |
Fluid intake reduced | 54.76 | 13.28 | 48 | 65070 | 2922 | 29884438 |
Stoma complication | 54.16 | 13.28 | 19 | 65099 | 171 | 29887189 |
Obsessive-compulsive disorder | 53.56 | 13.28 | 55 | 65063 | 4086 | 29883274 |
Sexually inappropriate behaviour | 53.39 | 13.28 | 22 | 65096 | 318 | 29887042 |
Libido increased | 52.89 | 13.28 | 29 | 65089 | 815 | 29886545 |
Septic shock | 52.58 | 13.28 | 37 | 65081 | 63570 | 29823790 |
Cough | 52.19 | 13.28 | 123 | 64995 | 125519 | 29761841 |
Chest pain | 51.42 | 13.28 | 112 | 65006 | 117515 | 29769845 |
Vomiting | 51.24 | 13.28 | 275 | 64843 | 219543 | 29667817 |
Angioedema | 51.21 | 13.28 | 7 | 65111 | 34377 | 29852983 |
Interstitial lung disease | 51.12 | 13.28 | 34 | 65084 | 60163 | 29827197 |
Rapid eye movement sleep behaviour disorder | 50.93 | 13.28 | 16 | 65102 | 98 | 29887262 |
Off label use | 50.62 | 13.28 | 326 | 64792 | 248964 | 29638396 |
Suspiciousness | 50.54 | 13.28 | 22 | 65096 | 367 | 29886993 |
Stoma site oedema | 49.88 | 13.28 | 12 | 65106 | 20 | 29887340 |
Device loosening | 49.86 | 13.28 | 14 | 65104 | 54 | 29887306 |
Illusion | 49.82 | 13.28 | 27 | 65091 | 741 | 29886619 |
Compulsive sexual behaviour | 49.08 | 13.28 | 19 | 65099 | 231 | 29887129 |
Epistaxis | 49.07 | 13.28 | 27 | 65091 | 52954 | 29834406 |
Loss of personal independence in daily activities | 48.62 | 13.28 | 129 | 64989 | 21406 | 29865954 |
Product dose omission issue | 48.35 | 13.28 | 353 | 64765 | 91278 | 29796082 |
Sleep disorder | 47.73 | 13.28 | 139 | 64979 | 24340 | 29863020 |
Treatment failure | 47.30 | 13.28 | 9 | 65109 | 34670 | 29852690 |
Rehabilitation therapy | 47.09 | 13.28 | 24 | 65094 | 579 | 29886781 |
Anaphylactic reaction | 45.97 | 13.28 | 4 | 65114 | 27978 | 29859382 |
Supine hypertension | 45.07 | 13.28 | 18 | 65100 | 239 | 29887121 |
Paraphilia | 44.95 | 13.28 | 14 | 65104 | 83 | 29887277 |
Fracture | 44.57 | 13.28 | 60 | 65058 | 5946 | 29881414 |
Bone marrow failure | 44.51 | 13.28 | 6 | 65112 | 29779 | 29857581 |
Oropharyngeal pain | 44.39 | 13.28 | 5 | 65113 | 28491 | 29858869 |
Asthma | 44.12 | 13.28 | 12 | 65106 | 36162 | 29851198 |
Enteral nutrition | 43.43 | 13.28 | 12 | 65106 | 43 | 29887317 |
Cardiac failure congestive | 43.31 | 13.28 | 73 | 65045 | 84334 | 29803026 |
Terminal state | 43.27 | 13.28 | 46 | 65072 | 3558 | 29883802 |
Blood glucose increased | 43.18 | 13.28 | 42 | 65076 | 61488 | 29825872 |
Hepatic enzyme increased | 42.99 | 13.28 | 10 | 65108 | 33484 | 29853876 |
Neuropathy peripheral | 42.98 | 13.28 | 54 | 65064 | 70421 | 29816939 |
Pancreatitis | 42.85 | 13.28 | 13 | 65105 | 36477 | 29850883 |
Erythema | 42.56 | 13.28 | 64 | 65054 | 77387 | 29809973 |
Constipation | 42.46 | 13.28 | 403 | 64715 | 112503 | 29774857 |
Weight decreased | 42.42 | 13.28 | 508 | 64610 | 150413 | 29736947 |
Hyperglycaemia | 42.33 | 13.28 | 12 | 65106 | 35188 | 29852172 |
Initial insomnia | 42.13 | 13.28 | 39 | 65079 | 2550 | 29884810 |
Volvulus | 41.95 | 13.28 | 29 | 65089 | 1242 | 29886118 |
Therapeutic product effect incomplete | 41.92 | 13.28 | 165 | 64953 | 33669 | 29853691 |
Fine motor skill dysfunction | 41.91 | 13.28 | 28 | 65090 | 1133 | 29886227 |
Medical device removal | 41.81 | 13.28 | 15 | 65103 | 145 | 29887215 |
Depressed mood | 41.52 | 13.28 | 105 | 65013 | 16924 | 29870436 |
Injection site pain | 41.05 | 13.28 | 8 | 65110 | 30302 | 29857058 |
Haemoglobin decreased | 41.04 | 13.28 | 120 | 64998 | 113978 | 29773382 |
Hypersensitivity | 40.14 | 13.28 | 35 | 65083 | 53993 | 29833367 |
Device placement issue | 39.98 | 13.28 | 9 | 65109 | 9 | 29887351 |
Blood bilirubin increased | 39.64 | 13.28 | 15 | 65103 | 36621 | 29850739 |
Product use in unapproved indication | 39.43 | 13.28 | 62 | 65056 | 73631 | 29813729 |
Nasopharyngitis | 39.21 | 13.28 | 42 | 65076 | 58807 | 29828553 |
Wheelchair user | 38.96 | 13.28 | 25 | 65093 | 944 | 29886416 |
Impulsive behaviour | 38.74 | 13.28 | 33 | 65085 | 1932 | 29885428 |
Influenza like illness | 38.64 | 13.28 | 5 | 65113 | 25600 | 29861760 |
Chest discomfort | 38.19 | 13.28 | 26 | 65092 | 45454 | 29841906 |
Salivary hypersecretion | 38.07 | 13.28 | 63 | 65055 | 7503 | 29879857 |
Hepatic function abnormal | 37.95 | 13.28 | 22 | 65096 | 41923 | 29845437 |
Chills | 37.63 | 13.28 | 62 | 65056 | 72276 | 29815084 |
Disease progression | 37.47 | 13.28 | 73 | 65045 | 79801 | 29807559 |
Product use complaint | 37.35 | 13.28 | 26 | 65092 | 1126 | 29886234 |
Medical device site dryness | 37.29 | 13.28 | 10 | 65108 | 31 | 29887329 |
Gastrostomy | 37.27 | 13.28 | 22 | 65096 | 714 | 29886646 |
Apathy | 37.03 | 13.28 | 56 | 65062 | 6176 | 29881184 |
Therapeutic product effect decreased | 37.00 | 13.28 | 143 | 64975 | 28933 | 29858427 |
Camptocormia | 36.94 | 13.28 | 14 | 65104 | 160 | 29887200 |
Medical device pain | 36.88 | 13.28 | 11 | 65107 | 55 | 29887305 |
Ascites | 36.76 | 13.28 | 16 | 65102 | 35905 | 29851455 |
Hepatic failure | 36.73 | 13.28 | 14 | 65104 | 34029 | 29853331 |
Hypokalaemia | 36.70 | 13.28 | 33 | 65085 | 50159 | 29837201 |
Head injury | 36.45 | 13.28 | 100 | 65018 | 16920 | 29870440 |
Diabetes mellitus | 36.41 | 13.28 | 23 | 65095 | 41842 | 29845518 |
Deep vein thrombosis | 36.22 | 13.28 | 47 | 65071 | 60454 | 29826906 |
Coronary artery disease | 35.97 | 13.28 | 33 | 65085 | 49679 | 29837681 |
Drug abuse | 35.96 | 13.28 | 78 | 65040 | 81994 | 29805366 |
Dysarthria | 35.62 | 13.28 | 146 | 64972 | 30344 | 29857016 |
Sinusitis | 35.50 | 13.28 | 14 | 65104 | 33331 | 29854029 |
Chronic kidney disease | 35.45 | 13.28 | 19 | 65099 | 37819 | 29849541 |
Inguinal hernia | 35.23 | 13.28 | 59 | 65059 | 7096 | 29880264 |
Immobile | 34.55 | 13.28 | 32 | 65086 | 2094 | 29885266 |
Dyspnoea exertional | 34.37 | 13.28 | 17 | 65101 | 35413 | 29851947 |
Multiple organ dysfunction syndrome | 34.35 | 13.28 | 53 | 65065 | 63434 | 29823926 |
Hepatocellular injury | 33.92 | 13.28 | 7 | 65111 | 25464 | 29861896 |
Food interaction | 33.76 | 13.28 | 22 | 65096 | 853 | 29886507 |
Drug reaction with eosinophilia and systemic symptoms | 33.72 | 13.28 | 10 | 65108 | 28478 | 29858882 |
Tachycardia | 33.21 | 13.28 | 69 | 65049 | 73670 | 29813690 |
Sepsis | 33.04 | 13.28 | 185 | 64933 | 146210 | 29741150 |
Femur fracture | 33.00 | 13.28 | 58 | 65060 | 7251 | 29880109 |
Gastrointestinal motility disorder | 32.99 | 13.28 | 32 | 65086 | 2219 | 29885141 |
Behaviour disorder | 32.95 | 13.28 | 33 | 65085 | 2379 | 29884981 |
Liver function test abnormal | 32.94 | 13.28 | 13 | 65105 | 30937 | 29856423 |
Wheezing | 32.92 | 13.28 | 13 | 65105 | 30925 | 29856435 |
Autonomic nervous system imbalance | 32.85 | 13.28 | 33 | 65085 | 2388 | 29884972 |
Medical device discomfort | 32.44 | 13.28 | 10 | 65108 | 57 | 29887303 |
Screaming | 31.81 | 13.28 | 25 | 65093 | 1306 | 29886054 |
Heart rate increased | 31.37 | 13.28 | 23 | 65095 | 38698 | 29848662 |
Therapeutic product effect delayed | 31.29 | 13.28 | 23 | 65095 | 1086 | 29886274 |
Respiratory failure | 31.22 | 13.28 | 113 | 65005 | 100529 | 29786831 |
Delusion of replacement | 31.14 | 13.28 | 12 | 65106 | 144 | 29887216 |
Therapeutic response unexpected | 30.72 | 13.28 | 63 | 65055 | 8840 | 29878520 |
Myocardial infarction | 30.42 | 13.28 | 155 | 64963 | 125470 | 29761890 |
Anxiety | 29.99 | 13.28 | 313 | 64805 | 89558 | 29797802 |
Atrial fibrillation | 29.97 | 13.28 | 127 | 64991 | 107997 | 29779363 |
Communication disorder | 29.87 | 13.28 | 30 | 65088 | 2170 | 29885190 |
Device power source issue | 29.76 | 13.28 | 14 | 65104 | 282 | 29887078 |
Neutrophil count decreased | 29.75 | 13.28 | 29 | 65089 | 42425 | 29844935 |
Osteonecrosis of jaw | 29.68 | 13.28 | 3 | 65115 | 18615 | 29868745 |
Cellulitis | 29.41 | 13.28 | 35 | 65083 | 46749 | 29840611 |
Daydreaming | 29.04 | 13.28 | 16 | 65102 | 454 | 29886906 |
Therapy non-responder | 28.77 | 13.28 | 14 | 65104 | 29439 | 29857921 |
Persecutory delusion | 28.72 | 13.28 | 29 | 65089 | 2111 | 29885249 |
Joint swelling | 28.58 | 13.28 | 36 | 65082 | 46910 | 29840450 |
Dementia with Lewy bodies | 28.49 | 13.28 | 17 | 65101 | 563 | 29886797 |
Chronic obstructive pulmonary disease | 28.47 | 13.28 | 35 | 65083 | 46091 | 29841269 |
Acute myeloid leukaemia | 28.45 | 13.28 | 3 | 65115 | 18003 | 29869357 |
Progressive supranuclear palsy | 28.26 | 13.28 | 9 | 65109 | 58 | 29887302 |
Hypocalcaemia | 28.20 | 13.28 | 6 | 65112 | 21370 | 29865990 |
Fluid overload | 28.16 | 13.28 | 4 | 65114 | 19088 | 29868272 |
Multiple system atrophy | 27.80 | 13.28 | 12 | 65106 | 196 | 29887164 |
Blood alkaline phosphatase increased | 27.79 | 13.28 | 17 | 65101 | 31470 | 29855890 |
Hallucination, auditory | 27.76 | 13.28 | 64 | 65054 | 9725 | 29877635 |
Liver disorder | 27.73 | 13.28 | 15 | 65103 | 29707 | 29857653 |
Gastrointestinal haemorrhage | 27.70 | 13.28 | 91 | 65027 | 83355 | 29804005 |
Myelodysplastic syndrome | 27.54 | 13.28 | 4 | 65114 | 18774 | 29868586 |
Rapid eye movements sleep abnormal | 27.41 | 13.28 | 12 | 65106 | 203 | 29887157 |
Intentional overdose | 27.19 | 13.28 | 30 | 65088 | 41451 | 29845909 |
Chorea | 27.17 | 13.28 | 21 | 65097 | 1070 | 29886290 |
Nasal congestion | 27.13 | 13.28 | 4 | 65114 | 18562 | 29868798 |
Swelling | 27.09 | 13.28 | 23 | 65095 | 35952 | 29851408 |
Back pain | 26.92 | 13.28 | 123 | 64995 | 102473 | 29784887 |
Hallucinations, mixed | 26.86 | 13.28 | 30 | 65088 | 2453 | 29884907 |
Pain | 26.82 | 13.28 | 243 | 64875 | 172398 | 29714962 |
Mental disorder | 26.82 | 13.28 | 77 | 65041 | 13372 | 29873988 |
Hypoxia | 26.80 | 13.28 | 39 | 65079 | 47815 | 29839545 |
Postoperative delirium | 26.50 | 13.28 | 8 | 65110 | 42 | 29887318 |
Acute psychosis | 26.24 | 13.28 | 26 | 65092 | 1850 | 29885510 |
Acute myocardial infarction | 26.04 | 13.28 | 47 | 65071 | 52892 | 29834468 |
Lactic acidosis | 25.99 | 13.28 | 18 | 65100 | 31195 | 29856165 |
Abnormal faeces | 25.89 | 13.28 | 30 | 65088 | 2553 | 29884807 |
Disturbance in attention | 25.87 | 13.28 | 106 | 65012 | 22023 | 29865337 |
Product availability issue | 25.48 | 13.28 | 17 | 65101 | 686 | 29886674 |
Inflammatory marker increased | 25.43 | 13.28 | 33 | 65085 | 3155 | 29884205 |
Postural reflex impairment | 25.32 | 13.28 | 6 | 65112 | 9 | 29887351 |
Medical device site injury | 25.32 | 13.28 | 6 | 65112 | 9 | 29887351 |
Device colour issue | 25.32 | 13.28 | 6 | 65112 | 9 | 29887351 |
Euthanasia | 25.19 | 13.28 | 8 | 65110 | 51 | 29887309 |
Stoma site abscess | 25.06 | 13.28 | 8 | 65110 | 52 | 29887308 |
Fatigue | 24.95 | 13.28 | 520 | 64598 | 320153 | 29567207 |
Device programming error | 24.94 | 13.28 | 6 | 65112 | 10 | 29887350 |
Medical device change | 24.89 | 13.28 | 10 | 65108 | 135 | 29887225 |
Acute respiratory distress syndrome | 24.74 | 13.28 | 10 | 65108 | 23462 | 29863898 |
Hypertension | 24.40 | 13.28 | 159 | 64959 | 121195 | 29766165 |
Intentional product use issue | 24.28 | 13.28 | 26 | 65092 | 36414 | 29850946 |
Parkinsonian crisis | 24.24 | 13.28 | 6 | 65112 | 12 | 29887348 |
Disseminated intravascular coagulation | 24.11 | 13.28 | 9 | 65109 | 22162 | 29865198 |
Dyschezia | 23.94 | 13.28 | 20 | 65098 | 1140 | 29886220 |
Cardiogenic shock | 23.80 | 13.28 | 4 | 65114 | 16857 | 29870503 |
Food refusal | 23.52 | 13.28 | 10 | 65108 | 157 | 29887203 |
Rhabdomyolysis | 23.48 | 13.28 | 66 | 65052 | 63514 | 29823846 |
Pneumoperitoneum | 23.45 | 13.28 | 23 | 65095 | 1617 | 29885743 |
Product use issue | 23.40 | 13.28 | 40 | 65078 | 45976 | 29841384 |
Marital problem | 23.10 | 13.28 | 8 | 65110 | 69 | 29887291 |
Jaundice | 22.98 | 13.28 | 22 | 65096 | 32464 | 29854896 |
Suspected COVID-19 | 22.98 | 13.28 | 12 | 65106 | 305 | 29887055 |
Obsessive-compulsive personality disorder | 22.91 | 13.28 | 10 | 65108 | 168 | 29887192 |
Hepatitis | 22.80 | 13.28 | 10 | 65108 | 22346 | 29865014 |
Sleep attacks | 22.80 | 13.28 | 10 | 65108 | 170 | 29887190 |
Pelvic fracture | 22.73 | 13.28 | 26 | 65092 | 2182 | 29885178 |
Insomnia | 22.70 | 13.28 | 306 | 64812 | 93030 | 29794330 |
Metabolic acidosis | 22.52 | 13.28 | 29 | 65089 | 37432 | 29849928 |
Incontinence | 22.43 | 13.28 | 41 | 65077 | 5285 | 29882075 |
Vitamin B6 decreased | 22.21 | 13.28 | 5 | 65113 | 5 | 29887355 |
Compulsions | 22.18 | 13.28 | 10 | 65108 | 182 | 29887178 |
Hepatotoxicity | 22.16 | 13.28 | 6 | 65112 | 18139 | 29869221 |
Anosmia | 22.08 | 13.28 | 25 | 65093 | 2075 | 29885285 |
Rash maculo-papular | 22.05 | 13.28 | 14 | 65104 | 25404 | 29861956 |
Feeding disorder | 22.00 | 13.28 | 43 | 65075 | 5828 | 29881532 |
Polyneuropathy | 21.96 | 13.28 | 66 | 65052 | 11757 | 29875603 |
Arthritis | 21.78 | 13.28 | 13 | 65105 | 24388 | 29862972 |
Palliative care | 21.76 | 13.28 | 12 | 65106 | 341 | 29887019 |
Fear of falling | 21.76 | 13.28 | 12 | 65106 | 341 | 29887019 |
Syncope | 21.75 | 13.28 | 281 | 64837 | 84622 | 29802738 |
Upper limb fracture | 21.66 | 13.28 | 35 | 65083 | 4085 | 29883275 |
Panic attack | 21.65 | 13.28 | 54 | 65064 | 8627 | 29878733 |
Medical device site erosion | 21.61 | 13.28 | 7 | 65111 | 48 | 29887312 |
Coronavirus infection | 21.59 | 13.28 | 32 | 65086 | 3466 | 29883894 |
Pneumonitis | 21.35 | 13.28 | 17 | 65101 | 27437 | 29859923 |
Saliva discolouration | 21.31 | 13.28 | 5 | 65113 | 7 | 29887353 |
Micturition urgency | 21.24 | 13.28 | 36 | 65082 | 4371 | 29882989 |
Skin exfoliation | 21.17 | 13.28 | 12 | 65106 | 23160 | 29864200 |
Torticollis | 21.09 | 13.28 | 18 | 65100 | 1057 | 29886303 |
Medical device site warmth | 20.91 | 13.28 | 5 | 65113 | 8 | 29887352 |
Hepatic encephalopathy | 20.87 | 13.28 | 3 | 65115 | 14189 | 29873171 |
Phlebitis infective | 20.74 | 13.28 | 9 | 65109 | 149 | 29887211 |
Gout | 20.63 | 13.28 | 6 | 65112 | 17309 | 29870051 |
Compulsive hoarding | 20.63 | 13.28 | 6 | 65112 | 27 | 29887333 |
Complication of device insertion | 20.61 | 13.28 | 8 | 65110 | 98 | 29887262 |
Wrong technique in product usage process | 20.60 | 13.28 | 127 | 64991 | 31028 | 29856332 |
Blood pressure fluctuation | 20.58 | 13.28 | 84 | 65034 | 17419 | 29869941 |
Anger | 20.58 | 13.28 | 62 | 65056 | 11058 | 29876302 |
Drug resistance | 20.54 | 13.28 | 9 | 65109 | 20124 | 29867236 |
Alien limb syndrome | 20.54 | 13.28 | 5 | 65113 | 9 | 29887351 |
Proteinuria | 20.36 | 13.28 | 5 | 65113 | 16140 | 29871220 |
Thrombosis | 20.31 | 13.28 | 38 | 65080 | 42193 | 29845167 |
Hypoglycaemia | 20.28 | 13.28 | 51 | 65067 | 50930 | 29836430 |
Neoplasm progression | 20.13 | 13.28 | 7 | 65111 | 18016 | 29869344 |
Gastrointestinal stoma complication | 20.13 | 13.28 | 19 | 65099 | 1273 | 29886087 |
Saliva altered | 20.00 | 13.28 | 9 | 65109 | 163 | 29887197 |
Dry skin | 19.99 | 13.28 | 12 | 65106 | 22442 | 29864918 |
Tubulointerstitial nephritis | 19.90 | 13.28 | 7 | 65111 | 17884 | 29869476 |
COVID-19 | 19.62 | 13.28 | 84 | 65034 | 17794 | 29869566 |
Serotonin syndrome | 19.59 | 13.28 | 84 | 65034 | 17807 | 29869553 |
Oedema | 19.54 | 13.28 | 40 | 65078 | 42953 | 29844407 |
Vitamin B6 deficiency | 19.42 | 13.28 | 9 | 65109 | 175 | 29887185 |
Hypomagnesaemia | 19.33 | 13.28 | 6 | 65112 | 16592 | 29870768 |
Impaired self-care | 19.30 | 13.28 | 16 | 65102 | 902 | 29886458 |
Pleural effusion | 19.29 | 13.28 | 89 | 65029 | 73977 | 29813383 |
Voyeurism | 19.29 | 13.28 | 5 | 65113 | 13 | 29887347 |
Herpes zoster | 19.25 | 13.28 | 22 | 65096 | 29921 | 29857439 |
Nasal discomfort | 19.24 | 13.28 | 18 | 65100 | 1193 | 29886167 |
Influenza | 19.20 | 13.28 | 41 | 65077 | 43357 | 29844003 |
Infrequent bowel movements | 19.20 | 13.28 | 14 | 65104 | 653 | 29886707 |
Sinus tachycardia | 19.17 | 13.28 | 5 | 65113 | 15499 | 29871861 |
Palpitations | 19.16 | 13.28 | 27 | 65091 | 33546 | 29853814 |
Catheter site discharge | 19.13 | 13.28 | 13 | 65105 | 541 | 29886819 |
Unresponsive to stimuli | 18.94 | 13.28 | 110 | 65008 | 26309 | 29861051 |
Gastric perforation | 18.93 | 13.28 | 23 | 65095 | 2058 | 29885302 |
Somatic delusion | 18.91 | 13.28 | 8 | 65110 | 124 | 29887236 |
Mitral valve sclerosis | 18.68 | 13.28 | 8 | 65110 | 128 | 29887232 |
Bone pain | 18.65 | 13.28 | 9 | 65109 | 19017 | 29868343 |
Cerebral atrophy | 18.51 | 13.28 | 34 | 65084 | 4399 | 29882961 |
Binge eating | 18.47 | 13.28 | 7 | 65111 | 80 | 29887280 |
Secretion discharge | 18.41 | 13.28 | 31 | 65087 | 3744 | 29883616 |
Skin ulcer | 18.34 | 13.28 | 9 | 65109 | 18840 | 29868520 |
Anaphylactic shock | 18.31 | 13.28 | 4 | 65114 | 13989 | 29873371 |
Economic problem | 18.21 | 13.28 | 19 | 65099 | 1438 | 29885922 |
Mastication disorder | 18.19 | 13.28 | 17 | 65101 | 1125 | 29886235 |
Hallucination, tactile | 18.17 | 13.28 | 10 | 65108 | 283 | 29887077 |
Medical device site pain | 18.16 | 13.28 | 7 | 65111 | 84 | 29887276 |
Urinary incontinence | 18.13 | 13.28 | 79 | 65039 | 16861 | 29870499 |
Mixed dementia | 18.09 | 13.28 | 9 | 65109 | 206 | 29887154 |
International normalised ratio increased | 18.03 | 13.28 | 49 | 65069 | 47690 | 29839670 |
Oesophageal achalasia | 17.95 | 13.28 | 10 | 65108 | 290 | 29887070 |
Feeding tube user | 17.83 | 13.28 | 6 | 65112 | 47 | 29887313 |
Sexual inhibition | 17.77 | 13.28 | 4 | 65114 | 4 | 29887356 |
Stoma site pruritus | 17.77 | 13.28 | 4 | 65114 | 4 | 29887356 |
Medical device site abscess | 17.77 | 13.28 | 4 | 65114 | 4 | 29887356 |
Alopecia | 17.58 | 13.28 | 10 | 65108 | 19265 | 29868095 |
Hypercalcaemia | 17.56 | 13.28 | 3 | 65115 | 12492 | 29874868 |
Bradyphrenia | 17.35 | 13.28 | 31 | 65087 | 3926 | 29883434 |
Splenomegaly | 17.35 | 13.28 | 4 | 65114 | 13476 | 29873884 |
Pneumothorax | 16.90 | 13.28 | 7 | 65111 | 16186 | 29871174 |
Panic reaction | 16.79 | 13.28 | 18 | 65100 | 1405 | 29885955 |
Upper respiratory tract infection | 16.79 | 13.28 | 21 | 65097 | 27455 | 29859905 |
Soft tissue haemorrhage | 16.70 | 13.28 | 8 | 65110 | 168 | 29887192 |
Renal disorder | 16.65 | 13.28 | 16 | 65102 | 23568 | 29863792 |
Angina pectoris | 16.58 | 13.28 | 24 | 65094 | 29494 | 29857866 |
Excessive masturbation | 16.58 | 13.28 | 7 | 65111 | 108 | 29887252 |
Medical device site scab | 16.50 | 13.28 | 4 | 65114 | 7 | 29887353 |
Medical device site discolouration | 16.50 | 13.28 | 4 | 65114 | 7 | 29887353 |
Transaminases increased | 16.46 | 13.28 | 16 | 65102 | 23441 | 29863919 |
Colitis | 16.40 | 13.28 | 26 | 65092 | 30794 | 29856566 |
Decreased interest | 16.40 | 13.28 | 22 | 65096 | 2173 | 29885187 |
Pain in extremity | 16.29 | 13.28 | 157 | 64961 | 110064 | 29777296 |
Respiratory dyskinesia | 16.29 | 13.28 | 5 | 65113 | 28 | 29887332 |
Hypertonia | 16.29 | 13.28 | 32 | 65086 | 4353 | 29883007 |
Drug interaction | 16.25 | 13.28 | 321 | 64797 | 199247 | 29688113 |
Hepatic steatosis | 16.09 | 13.28 | 6 | 65112 | 14787 | 29872573 |
Thunderclap headache | 16.03 | 13.28 | 6 | 65112 | 66 | 29887294 |
Verbal abuse | 16.00 | 13.28 | 8 | 65110 | 185 | 29887175 |
Ventricular tachycardia | 15.92 | 13.28 | 17 | 65101 | 23845 | 29863515 |
Osteomyelitis | 15.89 | 13.28 | 6 | 65112 | 14675 | 29872685 |
Nervousness | 15.83 | 13.28 | 59 | 65059 | 11729 | 29875631 |
Impaired quality of life | 15.83 | 13.28 | 18 | 65100 | 1501 | 29885859 |
Haemoptysis | 15.81 | 13.28 | 27 | 65091 | 31051 | 29856309 |
Flushing | 15.58 | 13.28 | 25 | 65093 | 29467 | 29857893 |
Lymphadenopathy | 15.57 | 13.28 | 18 | 65100 | 24358 | 29863002 |
Colitis ulcerative | 15.46 | 13.28 | 6 | 65112 | 14428 | 29872932 |
Psychotic behaviour | 15.43 | 13.28 | 11 | 65107 | 495 | 29886865 |
Poisoning | 15.42 | 13.28 | 3 | 65115 | 11379 | 29875981 |
Soft tissue mass | 15.42 | 13.28 | 9 | 65109 | 286 | 29887074 |
Fluid replacement | 15.40 | 13.28 | 3 | 65115 | 0 | 29887360 |
Gamma-glutamyltransferase increased | 15.40 | 13.28 | 25 | 65093 | 29325 | 29858035 |
Grimacing | 15.39 | 13.28 | 9 | 65109 | 287 | 29887073 |
Medical device site discharge | 15.35 | 13.28 | 5 | 65113 | 35 | 29887325 |
Dependence | 15.34 | 13.28 | 16 | 65102 | 1210 | 29886150 |
Drug intolerance | 15.29 | 13.28 | 49 | 65069 | 45242 | 29842118 |
Medical device site ulcer | 15.27 | 13.28 | 4 | 65114 | 11 | 29887349 |
Emotional disorder | 15.22 | 13.28 | 34 | 65084 | 5060 | 29882300 |
Blood cholesterol increased | 15.20 | 13.28 | 9 | 65109 | 16961 | 29870399 |
Hyperbilirubinaemia | 15.16 | 13.28 | 9 | 65109 | 16933 | 29870427 |
Hepatic cirrhosis | 15.03 | 13.28 | 8 | 65110 | 15991 | 29871369 |
Faecaloma | 15.00 | 13.28 | 31 | 65087 | 4374 | 29882986 |
Delusional disorder, unspecified type | 14.98 | 13.28 | 13 | 65105 | 781 | 29886579 |
Rash erythematous | 14.97 | 13.28 | 16 | 65102 | 22436 | 29864924 |
Coagulopathy | 14.95 | 13.28 | 11 | 65107 | 18476 | 29868884 |
Electrocardiogram QT prolonged | 14.92 | 13.28 | 35 | 65083 | 35800 | 29851560 |
Medical device site infection | 14.91 | 13.28 | 8 | 65110 | 215 | 29887145 |
Hyperthermia | 14.80 | 13.28 | 52 | 65066 | 10047 | 29877313 |
Patient uncooperative | 14.79 | 13.28 | 7 | 65111 | 143 | 29887217 |
Defiant behaviour | 14.77 | 13.28 | 4 | 65114 | 13 | 29887347 |
Tricuspid valve sclerosis | 14.77 | 13.28 | 5 | 65113 | 40 | 29887320 |
Obsessive thoughts | 14.75 | 13.28 | 12 | 65106 | 659 | 29886701 |
Marasmus | 14.57 | 13.28 | 11 | 65107 | 541 | 29886819 |
Anticholinergic syndrome | 14.56 | 13.28 | 13 | 65105 | 811 | 29886549 |
Protrusion tongue | 14.46 | 13.28 | 8 | 65110 | 229 | 29887131 |
Migraine | 14.38 | 13.28 | 5 | 65113 | 12869 | 29874491 |
Eye haematoma | 14.35 | 13.28 | 5 | 65113 | 44 | 29887316 |
Gastric fistula | 14.25 | 13.28 | 5 | 65113 | 45 | 29887315 |
Hypermobility syndrome | 14.18 | 13.28 | 8 | 65110 | 238 | 29887122 |
Pericardial effusion | 14.18 | 13.28 | 15 | 65103 | 21129 | 29866231 |
Decreased activity | 14.15 | 13.28 | 27 | 65091 | 3594 | 29883766 |
Skin maceration | 14.13 | 13.28 | 4 | 65114 | 16 | 29887344 |
Toxic epidermal necrolysis | 14.09 | 13.28 | 11 | 65107 | 17929 | 29869431 |
Electrocardiogram QT interval | 14.06 | 13.28 | 5 | 65113 | 47 | 29887313 |
Contraindicated product prescribed | 14.02 | 13.28 | 9 | 65109 | 340 | 29887020 |
Nephropathy toxic | 14.01 | 13.28 | 3 | 65115 | 10636 | 29876724 |
Wrong device used | 13.94 | 13.28 | 4 | 65114 | 17 | 29887343 |
Cystitis | 13.93 | 13.28 | 45 | 65073 | 8329 | 29879031 |
Adrenal insufficiency | 13.67 | 13.28 | 3 | 65115 | 10460 | 29876900 |
Eosinophilic fasciitis | 13.63 | 13.28 | 6 | 65112 | 103 | 29887257 |
Ventricular fibrillation | 13.60 | 13.28 | 8 | 65110 | 15130 | 29872230 |
Cervical vertebral fracture | 13.59 | 13.28 | 18 | 65100 | 1756 | 29885604 |
Device material issue | 13.58 | 13.28 | 4 | 65114 | 19 | 29887341 |
Stevens-Johnson syndrome | 13.49 | 13.28 | 11 | 65107 | 17545 | 29869815 |
Drug eruption | 13.44 | 13.28 | 11 | 65107 | 17515 | 29869845 |
Mood altered | 13.43 | 13.28 | 44 | 65074 | 8206 | 29879154 |
Blood lactate dehydrogenase increased | 13.39 | 13.28 | 15 | 65103 | 20586 | 29866774 |
Medical device site necrosis | 13.33 | 13.28 | 3 | 65115 | 3 | 29887357 |
Device-device incompatibility | 13.33 | 13.28 | 3 | 65115 | 3 | 29887357 |
Propulsive gait | 13.33 | 13.28 | 3 | 65115 | 3 | 29887357 |
Stoma site hypersensitivity | 13.33 | 13.28 | 3 | 65115 | 3 | 29887357 |
Medical device battery replacement | 13.33 | 13.28 | 3 | 65115 | 3 | 29887357 |
Social stay hospitalisation | 13.33 | 13.28 | 3 | 65115 | 3 | 29887357 |
Medical device site granuloma | 13.33 | 13.28 | 3 | 65115 | 3 | 29887357 |
Stoma site cellulitis | 13.33 | 13.28 | 3 | 65115 | 3 | 29887357 |
Foreign body in throat | 13.28 | 13.28 | 5 | 65113 | 56 | 29887304 |
Source | Code | Description |
---|---|---|
ATC | N04BA01 | NERVOUS SYSTEM ANTI-PARKINSON DRUGS DOPAMINERGIC AGENTS Dopa and dopa derivatives |
ATC | N04BA02 | NERVOUS SYSTEM ANTI-PARKINSON DRUGS DOPAMINERGIC AGENTS Dopa and dopa derivatives |
ATC | N04BA03 | NERVOUS SYSTEM ANTI-PARKINSON DRUGS DOPAMINERGIC AGENTS Dopa and dopa derivatives |
FDA CS | M0370111 | Amino Acids, Aromatic |
MeSH PA | D018726 | Anti-Dyskinesia Agents |
MeSH PA | D000978 | Antiparkinson Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D015259 | Dopamine Agents |
MeSH PA | D018377 | Neurotransmitter Agents |
CHEBI has role | CHEBI:35219 | plant growth inhibitors |
CHEBI has role | CHEBI:48407 | antiparkinson agent |
CHEBI has role | CHEBI:48560 | dopamine agents |
CHEBI has role | CHEBI:50266 | prodrugs |
CHEBI has role | CHEBI:50910 | agente neurotoxico |
CHEBI has role | CHEBI:59174 | haptens |
CHEBI has role | CHEBI:62215 | allelochemicals |
CHEBI has role | CHEBI:66956 | antidyskinetic drugs |
CHEBI has role | CHEBI:75771 | mus musculus metabolite |
CHEBI has role | CHEBI:76924 | plant metabolites |
CHEBI has role | CHEBI:77746 | h. sapiens metabolites |
FDA EPC | N0000193220 | Aromatic Amino Acid |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Postencephalitic parkinsonism | indication | 19972008 | DOID:14332 |
Parkinsonism | indication | 32798002 | |
Parkinson's disease | indication | 49049000 | DOID:14330 |
Restless legs | off-label use | 32914008 | DOID:0050425 |
Age-related macular degeneration | off-label use | 267718000 | DOID:10871 |
Suicidal thoughts | contraindication | 6471006 | |
Hallucinations | contraindication | 7011001 | |
Dyskinesia | contraindication | 9748009 | |
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Disorder of lung | contraindication | 19829001 | DOID:850 |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Orthostatic hypotension | contraindication | 28651003 | |
Obstruction of bile duct | contraindication | 30144000 | |
Depressive disorder | contraindication | 35489007 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Duodenal ulcer disease | contraindication | 51868009 | DOID:1724 |
Diarrhea | contraindication | 62315008 | |
Psychotic disorder | contraindication | 69322001 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Gastrointestinal hemorrhage | contraindication | 74474003 | |
Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Acute disease of cardiovascular system | contraindication | 128487001 | |
Seizure disorder | contraindication | 128613002 | |
Drug-induced psychosis | contraindication | 191483003 | DOID:1742 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Retention of urine | contraindication | 267064002 | |
Psychoneurotic personality disorder | contraindication | 268634009 | |
Malignant melanoma | contraindication | 372244006 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Cardiovascular event risk | contraindication | 395112001 | |
Gastric ulcer | contraindication | 397825006 | DOID:10808 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 2.31 | acidic |
pKa2 | 9.07 | acidic |
pKa3 | 13.05 | acidic |
pKa4 | 10.01 | Basic |
None
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
42MG | INBRIJA | ACORDA | N209184 | Dec. 21, 2018 | RX | POWDER | INHALATION | Dec. 21, 2021 | NEW PRODUCT |
4.63MG/ML;20MG/ML | DUOPA | ABBVIE INC | N203952 | Jan. 9, 2015 | RX | SUSPENSION | ENTERAL | Jan. 9, 2022 | TREATMENT OF MOTOR FLUCTUATIONS IN PATIENTS WITH ADVANCED PARKINSONS DISEASE |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
D(2) dopamine receptor | GPCR | AGONIST | WOMBAT-PK | SCIENTIFIC LITERATURE | |||||
D(1A) dopamine receptor | GPCR | AGONIST | WOMBAT-PK | SCIENTIFIC LITERATURE | |||||
Epidermal growth factor receptor | Kinase | IC50 | 5.54 | DRUG MATRIX | |||||
Tyrosine-protein kinase Lck | Kinase | IC50 | 5.43 | DRUG MATRIX | |||||
Tyrosine-protein kinase Fyn | Kinase | IC50 | 5.67 | DRUG MATRIX | |||||
Arachidonate 15-lipoxygenase | Enzyme | IC50 | 5.65 | DRUG MATRIX |
ID | Source |
---|---|
4017790 | VUID |
N0000146151 | NUI |
D00059 | KEGG_DRUG |
4017790 | VANDF |
C0023570 | UMLSCUI |
CHEBI:15765 | CHEBI |
DAH | PDB_CHEM_ID |
TY3 | PDB_CHEM_ID |
6047 | PUBCHEM_CID |
CHEMBL1009 | ChEMBL_ID |
DB01235 | DRUGBANK_ID |
D004295 | MESH_DESCRIPTOR_UI |
D007980 | MESH_DESCRIPTOR_UI |
3639 | IUPHAR_LIGAND_ID |
2651 | INN_ID |
46627O600J | UNII |
6375 | RXNORM |
1804 | MMSL |
4971 | MMSL |
d00277 | MMSL |
001639 | NDDF |
15383004 | SNOMEDCT_US |
387086006 | SNOMEDCT_US |
65955006 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
SINEMET | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0006-3915 | TABLET | 100 mg | ORAL | NDA | 25 sections |
SINEMET | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0006-3916 | TABLET | 100 mg | ORAL | NDA | 25 sections |
SINEMET | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0006-3917 | TABLET | 250 mg | ORAL | NDA | 25 sections |
SINEMET | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0006-6722 | TABLET | 100 mg | ORAL | NDA | 25 sections |
SINEMET | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0006-6723 | TABLET | 250 mg | ORAL | NDA | 25 sections |
SINEMET | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0006-6724 | TABLET | 100 mg | ORAL | NDA | 25 sections |
Duopa | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0074-3012 | SUSPENSION | 20 mg | ENTERAL | NDA | 27 sections |
Stalevo | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0407 | TABLET, FILM COATED | 50 mg | ORAL | NDA | 25 sections |
Stalevo | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0408 | TABLET, FILM COATED | 100 mg | ORAL | NDA | 25 sections |
Stalevo | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0409 | TABLET, FILM COATED | 150 mg | ORAL | NDA | 25 sections |
Stalevo | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0527 | TABLET, FILM COATED | 200 mg | ORAL | NDA | 25 sections |
Stalevo | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0544 | TABLET, FILM COATED | 75 mg | ORAL | NDA | 25 sections |
Stalevo | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0545 | TABLET, FILM COATED | 125 mg | ORAL | NDA | 25 sections |
Carbidopa and levodopa | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0228-2538 | TABLET | 100 mg | ORAL | ANDA | 11 sections |
Carbidopa and levodopa | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0228-2539 | TABLET | 100 mg | ORAL | ANDA | 11 sections |
Carbidopa and levodopa | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0228-2540 | TABLET | 250 mg | ORAL | ANDA | 11 sections |
Carbidopa and Levodopa | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-0078 | TABLET | 100 mg | ORAL | ANDA | 24 sections |
Carbidopa and Levodopa | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-0085 | TABLET | 100 mg | ORAL | ANDA | 24 sections |
Carbidopa and Levodopa | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-0088 | TABLET, EXTENDED RELEASE | 100 mg | ORAL | ANDA | 24 sections |
Carbidopa and Levodopa | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-0094 | TABLET, EXTENDED RELEASE | 200 mg | ORAL | ANDA | 24 sections |
Carbidopa and Levodopa | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-1133 | TABLET | 250 mg | ORAL | ANDA | 24 sections |
Carbidopa, Levodopa and Entacapone | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0378-8300 | TABLET, FILM COATED | 50 mg | ORAL | NDA authorized generic | 24 sections |
Carbidopa, Levodopa and Entacapone | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0378-8301 | TABLET, FILM COATED | 75 mg | ORAL | NDA authorized generic | 24 sections |
Carbidopa, Levodopa and Entacapone | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0378-8302 | TABLET, FILM COATED | 100 mg | ORAL | NDA authorized generic | 24 sections |
Carbidopa, Levodopa and Entacapone | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0378-8303 | TABLET, FILM COATED | 125 mg | ORAL | NDA authorized generic | 24 sections |
Carbidopa, Levodopa and Entacapone | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0378-8304 | TABLET, FILM COATED | 150 mg | ORAL | NDA authorized generic | 24 sections |
Carbidopa, Levodopa and Entacapone | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0378-8305 | TABLET, FILM COATED | 200 mg | ORAL | NDA authorized generic | 24 sections |
Carbidopa and Levodopa | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0615-4568 | TABLET, EXTENDED RELEASE | 200 mg | ORAL | ANDA | 11 sections |
Carbidopa and Levodopa | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0615-4569 | TABLET, EXTENDED RELEASE | 100 mg | ORAL | ANDA | 11 sections |
Carbidopa and levodopa | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0615-8067 | TABLET | 100 mg | ORAL | ANDA | 12 sections |