levetiracetam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
amide type nootrope agents, piracetam derivatives 1563 102767-28-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • keppra
  • levetiracetam
  • matever
  • (-)-Levetiracetam
  • levroxa
  • UCB-6474
  • UCB 6474
The precise mechanism(s) by which levetiracetam exerts its antiepileptic effect is unknown. The antiepileptic activity of levetiracetam was assessed in a number of animal models of epileptic seizures. Levetiracetam did not inhibit single seizures induced by maximal stimulation with electrical current or different chemoconvulsants and showed only minimal activity in submaximal stimulation and in threshold tests. Protection was observed, however, against secondarily generalized activity from focal seizures induced by pilocarpine and kainic acid, two chemoconvulsants that induce seizures that mimic some features of human complex partial seizures with secondary generalization. Levetiracetam also displayed inhibitory properties in the kindling model in rats, another model of human complex partial seizures, both during kindling development and in the fully kindled state. In vitro and in vivo recordings of epileptiform activity from the hippocampus have shown that levetiracetam inhibits burst firing without affecting normal neuronal excitability, suggesting that levetiracetam may selectively prevent hypersynchronization of epileptiform burst firing and propagation of seizure activity. Levetiracetam at concentrations of up to 10 uM did not demonstrate binding affinity for a variety of known receptors, such as those associated with benzodiazepines, GABA (gamma-aminobutyric acid), glycine, NMDA (N-methyl-D-aspartate), re-uptake sites, and second messenger systems. Furthermore, in vitro studies have failed to find an effect of levetiracetam on neuronal voltage-gated sodium or T-type calcium currents and levetiracetam does not appear to directly facilitate GABAergic neurotransmission. However, in vitro studies have demonstrated that levetiracetam opposes the activity of negative modulators of GABA- and glycine-gated currents and partially inhibits N-type calcium currents in neuronal cells. A saturable and stereoselective neuronal binding site in rat brain tissue has been described for levetiracetam. Experimental data indicate that this binding site is the synaptic vesicle protein SV2A, thought to be involved in the regulation of vesicle exocytosis. Although the molecular significance of levetiracetam binding to synaptic vesicle protein SV2A is not understood, levetiracetam and related analogs showed a rank order of affinity for SV2A which correlated with the potency of their antiseizure activity in audiogenic seizure-prone mice. These findings suggest that the interaction of levetiracetam with the SV2A protein may contribute to the antiepileptic mechanism of action of the drug.
  • Molecular weight: 170.21
  • Formula: C8H14N2O2
  • CLOGP: -0.34
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 63.40
  • ALOGS: 0.24
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1.50 g O
1.50 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1040 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 66 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 251.79 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.60 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.90 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.90 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 8.23 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Sept. 29, 2000 EMA
Nov. 30, 1999 FDA UCB INC
July 23, 2010 PMDA UCB Japan Co., Ltd

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 6097.32 11.00 3476 111551 129158 63244837
Abortion spontaneous 2484.14 11.00 1356 113671 45839 63328156
Status epilepticus 2407.66 11.00 940 114087 14293 63359702
Generalised tonic-clonic seizure 1526.48 11.00 834 114193 28182 63345813
Pregnancy 1402.65 11.00 858 114169 35978 63338017
Multiple-drug resistance 1221.75 11.00 429 114598 4741 63369254
Epilepsy 1217.19 11.00 702 114325 26363 63347632
Maternal exposure during pregnancy 993.49 11.00 1575 113452 218487 63155508
Partial seizures 781.86 11.00 320 114707 5522 63368473
Aggression 652.05 11.00 449 114578 23049 63350946
Exposure during pregnancy 602.28 11.00 1040 113987 154507 63219488
Product substitution issue 584.05 11.00 363 114664 15633 63358362
Focal dyscognitive seizures 524.62 11.00 198 114829 2723 63371272
Stillbirth 501.83 11.00 245 114782 6505 63367490
Petit mal epilepsy 481.16 11.00 200 114827 3594 63370401
Psychogenic seizure 479.93 11.00 161 114866 1531 63372464
Arthralgia 456.68 11.00 232 114795 569478 62804517
Pain 386.36 11.00 466 114561 740162 62633833
Rheumatoid arthritis 378.00 11.00 20 115007 253799 63120196
Joint swelling 370.95 11.00 72 114955 327594 63046401
Foetal exposure during pregnancy 365.30 11.00 365 114662 31597 63342398
Abortion induced 365.21 11.00 229 114798 10013 63363982
Drug reaction with eosinophilia and systemic symptoms 358.66 11.00 371 114656 33465 63340530
Arthropathy 344.96 11.00 20 115007 234772 63139223
Abdominal discomfort 334.01 11.00 85 114942 320800 63053195
Contraindicated product administered 330.92 11.00 15 115012 217633 63156362
Paradoxical drug reaction 327.64 11.00 157 114870 3995 63370000
Irritability 324.25 11.00 341 114686 31353 63342642
Somnolence 317.08 11.00 872 114155 177813 63196182
Synovitis 308.93 11.00 6 115021 186912 63187083
Myoclonic epilepsy 288.36 11.00 102 114925 1152 63372843
Swelling 282.58 11.00 75 114952 275303 63098692
Anticonvulsant drug level decreased 280.92 11.00 100 114927 1152 63372843
Drug resistance 278.97 11.00 271 114756 22662 63351333
Infusion related reaction 277.62 11.00 54 114973 245467 63128528
Drug interaction 274.86 11.00 976 114051 228155 63145840
Cytokine release syndrome 274.34 11.00 219 114808 14095 63359900
Glossodynia 266.51 11.00 14 115013 178862 63195133
Abnormal behaviour 264.02 11.00 255 114772 21171 63352824
Psychotic disorder 251.24 11.00 270 114757 25442 63348553
Thrombocytopenia 246.83 11.00 716 114311 150441 63223554
Dyspnoea 232.10 11.00 537 114490 660776 62713219
Overdose 231.81 11.00 589 114438 114489 63259506
Agitation 226.17 11.00 396 114631 59361 63314634
Encephalopathy 223.15 11.00 311 114716 38309 63335686
Drug ineffective for unapproved indication 216.05 11.00 287 114740 33776 63340219
Drug withdrawal convulsions 214.62 11.00 85 114942 1340 63372655
Sinusitis 210.33 11.00 74 114953 226579 63147416
Anticonvulsant drug level increased 209.47 11.00 85 114942 1432 63372563
Peripheral swelling 208.47 11.00 111 114916 265831 63108164
Behaviour disorder 207.91 11.00 106 114921 3093 63370902
Pericarditis 206.93 11.00 7 115020 131572 63242423
Myoclonus 205.26 11.00 194 114833 15674 63358321
Discomfort 204.17 11.00 30 114997 167344 63206651
Alopecia 201.39 11.00 189 114838 337347 63036648
Systemic lupus erythematosus 199.42 11.00 65 114962 208853 63165142
Drug ineffective 197.21 11.00 2811 112216 1041954 62332041
Premature delivery 194.91 11.00 257 114770 30024 63343971
Ataxia 180.00 11.00 177 114850 15018 63358977
Therapeutic product effect decreased 179.33 11.00 63 114964 193124 63180871
Sudden unexplained death in epilepsy 177.45 11.00 51 114976 272 63373723
Aphasia 166.18 11.00 249 114778 32751 63341244
Drug intolerance 165.79 11.00 189 114838 308472 63065523
Aura 165.09 11.00 65 114962 1008 63372987
Hypersensitivity 164.05 11.00 173 114854 292512 63081483
Wound 162.61 11.00 47 114980 163216 63210779
Rhabdomyolysis 162.07 11.00 288 114739 43663 63330332
Stevens-Johnson syndrome 159.41 11.00 211 114816 24739 63349256
Hyperammonaemic encephalopathy 159.20 11.00 81 114946 2353 63371642
Immune effector cell-associated neurotoxicity syndrome 158.38 11.00 79 114948 2198 63371797
Caesarean section 157.91 11.00 174 114853 16858 63357137
Pain in extremity 154.31 11.00 226 114801 331260 63042735
Partial seizures with secondary generalisation 152.50 11.00 48 114979 365 63373630
Infantile spasms 145.66 11.00 40 114987 175 63373820
Nasopharyngitis 145.04 11.00 148 114879 254109 63119886
Lower respiratory tract infection 143.46 11.00 32 114995 132275 63241720
Diarrhoea 140.45 11.00 744 114283 714622 62659373
Acute generalised exanthematous pustulosis 140.32 11.00 134 114893 10965 63363030
Impaired healing 138.34 11.00 13 115014 102529 63271466
Electroencephalogram abnormal 138.23 11.00 85 114942 3587 63370408
Musculoskeletal stiffness 137.48 11.00 82 114945 184536 63189459
Maternal drugs affecting foetus 135.61 11.00 96 114931 5146 63368849
Change in seizure presentation 134.99 11.00 44 114983 379 63373616
Substance-induced psychotic disorder 133.67 11.00 67 114960 1884 63372111
Seizure cluster 131.09 11.00 38 114989 210 63373785
Drug hypersensitivity 130.24 11.00 227 114800 310460 63063535
Maternal exposure during breast feeding 129.42 11.00 86 114941 4155 63369840
Small for dates baby 129.03 11.00 82 114945 3669 63370326
Psoriatic arthropathy 127.84 11.00 10 115017 91510 63282485
Hyperammonaemia 126.60 11.00 92 114935 5140 63368855
Low birth weight baby 125.89 11.00 104 114923 7025 63366970
Simple partial seizures 125.66 11.00 45 114982 528 63373467
Disturbance in attention 125.34 11.00 238 114789 37951 63336044
Nausea 125.16 11.00 972 114055 853499 62520496
Tonic convulsion 123.94 11.00 56 114971 1241 63372754
Off label use 122.20 11.00 1804 113223 672658 62701337
Cognitive disorder 122.12 11.00 295 114732 55520 63318475
Breast feeding 117.83 11.00 48 114979 817 63373178
Osteoarthritis 116.43 11.00 17 115010 95326 63278669
Neurotoxicity 115.24 11.00 148 114879 16842 63357153
Atonic seizures 113.60 11.00 43 114984 596 63373399
No adverse event 111.92 11.00 238 114789 41167 63332828
Toxicity to various agents 110.11 11.00 796 114231 246454 63127541
Irritable bowel syndrome 109.71 11.00 11 115016 82401 63291594
Aplastic anaemia 108.77 11.00 109 114918 9460 63364535
Hallucination, visual 107.87 11.00 153 114874 19145 63354850
Infection 106.79 11.00 156 114871 229017 63144978
Maternal exposure before pregnancy 106.14 11.00 97 114930 7506 63366489
Fatigue 103.73 11.00 1070 113957 886958 62487037
Asthma 103.19 11.00 51 114976 127510 63246485
Encephalitis autoimmune 101.72 11.00 51 114976 1435 63372560
Brain oedema 101.58 11.00 127 114900 14068 63359927
Exposure via breast milk 99.49 11.00 56 114971 2001 63371994
Injection site pain 98.95 11.00 56 114971 129744 63244251
Arthritis 98.94 11.00 43 114984 115878 63258117
Drug level increased 98.36 11.00 160 114867 22576 63351419
Anger 98.15 11.00 117 114910 12339 63361656
Suicidal ideation 97.26 11.00 291 114736 62130 63311865
Hepatic enzyme increased 96.95 11.00 135 114892 202193 63171802
Fibromyalgia 96.67 11.00 15 115012 80405 63293590
Malaise 95.78 11.00 408 114619 415546 62958449
Anticonvulsant drug level above therapeutic 95.30 11.00 36 114991 496 63373499
Pruritus 94.42 11.00 337 114690 361116 63012879
Glioblastoma multiforme 94.02 11.00 40 114987 763 63373232
Blood cholesterol increased 93.72 11.00 27 115000 94005 63279990
Hypertension 92.65 11.00 233 114794 279070 63094925
Hallucination, auditory 92.19 11.00 115 114912 12709 63361286
Pancytopenia 91.44 11.00 383 114644 96550 63277445
Mood altered 88.55 11.00 121 114906 14622 63359373
Hemiparesis 87.66 11.00 154 114873 23128 63350867
Back pain 86.33 11.00 222 114805 263923 63110072
Leukopenia 86.30 11.00 322 114705 76968 63297027
Propofol infusion syndrome 86.26 11.00 40 114987 943 63373052
Psychomotor hyperactivity 85.41 11.00 101 114926 10562 63363433
Respiratory disorder neonatal 83.08 11.00 42 114985 1203 63372792
Nystagmus 82.26 11.00 77 114950 6143 63367852
Anticonvulsant drug level below therapeutic 82.08 11.00 34 114993 605 63373390
Hypotonia 81.16 11.00 92 114935 9193 63364802
Brain neoplasm 79.83 11.00 65 114962 4301 63369694
Cough 79.06 11.00 269 114758 292474 63081521
Posterior reversible encephalopathy syndrome 79.05 11.00 125 114902 17220 63356775
Persecutory delusion 78.97 11.00 54 114973 2736 63371259
Gastrointestinal disorder 78.69 11.00 73 114954 131166 63242829
Coma 78.51 11.00 276 114751 64088 63309907
Toxic epidermal necrolysis 78.37 11.00 154 114873 25180 63348815
Drug level decreased 77.06 11.00 83 114944 7836 63366159
Abdominal pain upper 76.67 11.00 162 114865 206282 63167713
Weight gain poor 76.44 11.00 36 114991 880 63373115
Pleocytosis 76.07 11.00 35 114992 810 63373185
Agranulocytosis 75.60 11.00 151 114876 24983 63349012
Depressed level of consciousness 75.55 11.00 266 114761 61812 63312183
Knee arthroplasty 75.47 11.00 6 115021 54200 63319795
Diplopia 74.32 11.00 145 114882 23583 63350412
Mobility decreased 74.30 11.00 66 114961 121093 63252902
Speech disorder 71.60 11.00 198 114829 40431 63333564
Premature baby 71.49 11.00 132 114895 20603 63353392
Central nervous system lesion 71.12 11.00 92 114935 10543 63363452
Altered state of consciousness 70.47 11.00 147 114880 25083 63348912
Mitochondrial DNA mutation 70.00 11.00 27 115000 395 63373600
Psoriasis 69.96 11.00 35 114992 86922 63287073
Affective disorder 69.84 11.00 70 114957 6076 63367919
Intentional self-injury 67.51 11.00 146 114881 25541 63348454
Disorientation 67.29 11.00 190 114837 39262 63334733
Hip arthroplasty 67.11 11.00 5 115022 47641 63326354
Oedema peripheral 66.84 11.00 153 114874 189358 63184637
Hyponatraemia 66.74 11.00 388 114639 111512 63262483
Foetal growth restriction 66.29 11.00 75 114952 7478 63366517
Wheezing 66.28 11.00 46 114981 95549 63278446
Paranoia 65.87 11.00 93 114934 11586 63362409
Intentional product use issue 65.68 11.00 81 114946 127811 63246184
Selective eating disorder 65.61 11.00 43 114984 2029 63371966
Acute psychosis 64.76 11.00 46 114981 2479 63371516
Congenital cyst 64.74 11.00 14 115013 14 63373981
Intra-abdominal pressure increased 63.97 11.00 22 115005 227 63373768
Mental status changes 63.95 11.00 187 114840 39412 63334583
Cerebral haemorrhage 63.57 11.00 159 114868 30570 63343425
Hepatocellular injury 63.42 11.00 148 114879 27233 63346762
Delusion 62.38 11.00 92 114935 11925 63362070
Teratogenicity 61.67 11.00 22 115005 255 63373740
Glioblastoma 61.07 11.00 30 114997 807 63373188
Red blood cell sedimentation rate increased 60.87 11.00 5 115022 43977 63330018
Sopor 60.58 11.00 128 114899 22036 63351959
Inflammation 60.56 11.00 37 114990 82236 63291759
Injection site erythema 60.40 11.00 38 114989 83136 63290859
Blood pressure increased 59.47 11.00 128 114899 161934 63212061
Musculoskeletal pain 59.35 11.00 48 114979 92229 63281766
Stomatitis 59.27 11.00 100 114927 138625 63235370
Bronchitis 59.17 11.00 84 114943 124851 63249144
Abdominal pain 58.53 11.00 303 114724 293153 63080842
Suicide attempt 57.66 11.00 241 114786 60677 63313318
Hallucination 57.57 11.00 224 114803 54593 63319402
Ill-defined disorder 57.13 11.00 39 114988 81716 63292279
Intellectual disability 56.44 11.00 31 114996 1055 63372940
Product administration error 56.25 11.00 125 114902 22272 63351723
Suicidal behaviour 56.24 11.00 43 114984 2596 63371399
Epileptic aura 56.10 11.00 15 115012 58 63373937
Hypoventilation 55.60 11.00 55 114972 4699 63369296
Chest pain 55.22 11.00 203 114824 215756 63158239
Pre-eclampsia 54.91 11.00 75 114952 9058 63364937
Depressed mood 54.87 11.00 179 114848 40012 63333983
Cardiac failure congestive 54.71 11.00 52 114975 92381 63281614
Mutism 54.49 11.00 35 114992 1595 63372400
Cholestasis 54.41 11.00 146 114881 29288 63344707
Intentional overdose 53.59 11.00 271 114756 73881 63300114
Suppressed lactation 53.39 11.00 23 115004 453 63373542
Haemophagocytic lymphohistiocytosis 53.22 11.00 80 114947 10547 63363448
Bradycardia 53.19 11.00 268 114759 72959 63301036
Pneumatosis 52.03 11.00 22 115005 413 63373582
Learning disorder 51.32 11.00 25 115002 660 63373335
Dysarthria 51.09 11.00 182 114845 42529 63331466
Osteoporosis 50.96 11.00 20 115007 57318 63316677
Rash 50.59 11.00 714 114313 560157 62813838
Hypomagnesaemia 50.58 11.00 140 114887 28597 63345398
Cataract 50.55 11.00 20 115007 57033 63316962
Idiopathic generalised epilepsy 50.54 11.00 10 115017 3 63373992
Cerebellar ataxia 50.36 11.00 27 115000 875 63373120
Personality change 49.27 11.00 62 114965 6911 63367084
Excessive eye blinking 49.12 11.00 30 114997 1250 63372745
Deja vu 48.97 11.00 14 115013 73 63373922
Night sweats 48.66 11.00 14 115013 48800 63325195
Chest discomfort 48.15 11.00 78 114949 109891 63264104
Herpes zoster 48.09 11.00 47 114980 82415 63291580
Tremor 47.85 11.00 406 114621 131833 63242162
Intracranial tumour haemorrhage 47.82 11.00 17 115010 195 63373800
Hypothermia 47.50 11.00 87 114940 13494 63360501
CSF oligoclonal band present 47.08 11.00 20 115007 380 63373615
Pulmonary fibrosis 46.55 11.00 8 115019 39801 63334194
Injection site reaction 46.40 11.00 24 115003 58500 63315495
Bradycardia neonatal 46.27 11.00 26 115001 926 63373069
Toxic encephalopathy 45.70 11.00 58 114969 6521 63367474
Myocardial infarction 45.50 11.00 69 114958 99824 63274171
Granuloma annulare 45.01 11.00 22 115005 585 63373410
Affect lability 44.91 11.00 76 114951 11075 63362920
Staring 44.84 11.00 31 114996 1599 63372396
Thinking abnormal 44.82 11.00 74 114953 10569 63363426
Bradyphrenia 44.53 11.00 59 114968 6921 63367074
Accidental poisoning 44.30 11.00 22 115005 606 63373389
Dyspepsia 44.27 11.00 73 114954 102123 63271872
Treatment noncompliance 43.74 11.00 158 114869 37167 63336828
Injection site pruritus 43.06 11.00 14 115013 45102 63328893
Retrograde amnesia 42.80 11.00 20 115007 480 63373515
Blister 42.43 11.00 109 114918 129705 63244290
Acute hepatic failure 42.38 11.00 99 114928 18228 63355767
Dysmorphism 41.59 11.00 34 114993 2262 63371733
Malignant catatonia 41.21 11.00 15 115012 185 63373810
Nasal congestion 41.17 11.00 35 114992 65625 63308370
COVID-19 40.92 11.00 90 114937 113013 63260982
Therapeutic response unexpected 40.85 11.00 99 114928 18660 63355335
Confusional state 40.84 11.00 628 114399 235752 63138243
Toxic skin eruption 40.67 11.00 79 114948 12806 63361189
Mental disorder 40.51 11.00 121 114906 25798 63348197
Mood swings 40.49 11.00 97 114930 18151 63355844
Necrosis ischaemic 40.48 11.00 23 115004 837 63373158
Encephalitis 40.47 11.00 64 114963 8816 63365179
Limbic encephalitis 40.46 11.00 17 115010 314 63373681
Memory impairment 40.34 11.00 325 114702 103933 63270062
Metabolic encephalopathy 40.02 11.00 51 114976 5758 63368237
Joint stiffness 39.94 11.00 13 115014 41856 63332139
Sciatica 39.91 11.00 7 115020 34317 63339678
Post stroke depression 39.82 11.00 9 115018 13 63373982
Apnoea 39.61 11.00 60 114967 7962 63366033
Developmental glaucoma 39.37 11.00 11 115016 52 63373943
Congenital knee dislocation 39.29 11.00 8 115019 4 63373991
Flushing 39.12 11.00 47 114980 75040 63298955
Macroglossia 39.07 11.00 21 115006 684 63373311
Brain operation 39.05 11.00 20 115007 589 63373406
Postictal state 38.89 11.00 24 115003 1019 63372976
Febrile convulsion 38.75 11.00 18 115009 426 63373569
Crystal nephropathy 38.67 11.00 23 115004 913 63373082
Respiratory acidosis 38.65 11.00 54 114973 6661 63367334
Obsessive-compulsive disorder 38.53 11.00 42 114985 4018 63369977
JC polyomavirus test 38.40 11.00 10 115017 34 63373961
Blood pressure systolic increased 38.23 11.00 19 115008 47378 63326617
Loss of personal independence in daily activities 38.09 11.00 74 114953 97216 63276779
Ventricular tachycardia 37.83 11.00 100 114927 19879 63354116
Exomphalos 37.78 11.00 19 115008 538 63373457
Rash maculo-papular 37.36 11.00 135 114892 31761 63342234
Eosinophilia 37.25 11.00 108 114919 22648 63351347
Treatment failure 37.17 11.00 210 114817 198833 63175162
Joint range of motion decreased 36.87 11.00 7 115020 32421 63341574
Organic brain syndrome 36.79 11.00 14 115013 197 63373798
Blood gases abnormal 36.67 11.00 21 115006 776 63373219
Multiple organ dysfunction syndrome 36.60 11.00 201 114826 56551 63317444
Kounis syndrome 36.45 11.00 28 114999 1702 63372293
Angiofibroma 36.25 11.00 12 115015 109 63373886
Bursitis 36.23 11.00 11 115016 37030 63336965
Metastases to central nervous system 36.18 11.00 76 114951 13029 63360966
Delirium 36.01 11.00 184 114843 50357 63323638
Fluid retention 35.99 11.00 33 114994 59653 63314342
Injection site swelling 35.56 11.00 21 115006 47551 63326444
Ammonia increased 35.48 11.00 43 114984 4613 63369382
Gene mutation 35.20 11.00 27 115000 1638 63372357
Tongue biting 35.13 11.00 26 115001 1494 63372501
Gingival hypertrophy 35.11 11.00 27 115000 1644 63372351
Skin ulcer 35.11 11.00 17 115010 43028 63330967
Hyperthermia 35.03 11.00 61 114966 9095 63364900
Creutzfeldt-Jakob disease 35.03 11.00 13 115014 170 63373825
Weight increased 35.00 11.00 303 114724 260489 63113506
Hippocampal sclerosis 34.91 11.00 11 115016 84 63373911
Gastrooesophageal reflux disease 34.68 11.00 76 114951 95563 63278432
Neuropsychiatric symptoms 34.58 11.00 20 115007 753 63373242
Unresponsive to stimuli 34.54 11.00 137 114890 33679 63340316
Pneumonia aspiration 34.53 11.00 139 114888 34401 63339594
Brief psychotic disorder, with postpartum onset 34.47 11.00 9 115018 31 63373964
Apathy 34.18 11.00 59 114968 8735 63365260
Myalgia 34.07 11.00 143 114884 146386 63227609
Feeling hot 33.89 11.00 25 115002 50329 63323666
Porphyria acute 33.83 11.00 23 115004 1154 63372841
Muscle twitching 33.81 11.00 95 114932 19573 63354422
Dyskinesia 33.78 11.00 131 114896 31871 63342124
Necrotising colitis 33.53 11.00 18 115009 585 63373410
Osteonecrosis of jaw 33.34 11.00 11 115016 35112 63338883
Mania 33.30 11.00 71 114956 12296 63361699
Screaming 33.17 11.00 35 114992 3227 63370768
Urticaria 33.12 11.00 171 114856 165631 63208364
Meningioma 33.12 11.00 38 114989 3847 63370148
Contusion 32.72 11.00 150 114877 149894 63224101
Oedema 32.65 11.00 81 114946 97541 63276454
Postictal psychosis 32.54 11.00 8 115019 20 63373975
Blood creatine phosphokinase increased 32.48 11.00 125 114902 30305 63343690
Acute myocardial infarction 32.41 11.00 9 115018 32115 63341880
Autism spectrum disorder 32.39 11.00 20 115007 850 63373145
Retinogram abnormal 32.19 11.00 12 115015 159 63373836
Pemphigoid 32.19 11.00 52 114975 7292 63366703
Dry eye 31.89 11.00 17 115010 40744 63333251
Grey matter heterotopia 31.89 11.00 6 115021 0 63373995
Muscle spasms 31.78 11.00 160 114867 155990 63218005
Twin pregnancy 31.55 11.00 22 115005 1151 63372844
Productive cough 31.43 11.00 41 114986 63167 63310828
Hepatitis 31.30 11.00 149 114878 39639 63334356
Drug clearance increased 31.27 11.00 11 115016 122 63373873
Cross sensitivity reaction 30.99 11.00 28 114999 2134 63371861
Coronary artery disease 30.98 11.00 10 115017 32367 63341628
MELAS syndrome 30.64 11.00 11 115016 130 63373865
Head injury 30.44 11.00 114 114913 27282 63346713
Electrocardiogram QRS complex prolonged 30.16 11.00 45 114982 5893 63368102
Acidosis hyperchloraemic 30.15 11.00 15 115012 415 63373580
Spina bifida 30.10 11.00 19 115008 840 63373155
Blood pressure fluctuation 29.89 11.00 24 115003 46293 63327702
Eosinophilic cystitis 29.88 11.00 9 115018 58 63373937
Ankyloglossia congenital 29.85 11.00 12 115015 197 63373798
Restlessness 29.82 11.00 119 114908 29334 63344661
Meningitis aseptic 29.59 11.00 40 114987 4783 63369212
Poverty of thought content 29.54 11.00 7 115020 14 63373981
Necrobiosis lipoidica diabeticorum 29.51 11.00 8 115019 33 63373962
Constipation 29.44 11.00 263 114764 224680 63149315
Cerebral venous sinus thrombosis 29.18 11.00 26 115001 1946 63372049
Depression 29.08 11.00 509 114518 195983 63178012
Developmental delay 29.07 11.00 23 115004 1460 63372535
Cellulitis 29.00 11.00 66 114961 81892 63292103
Epileptic encephalopathy 28.94 11.00 13 115014 284 63373711
Apraxia 28.93 11.00 25 115002 1796 63372199
Diverticulitis 28.81 11.00 18 115009 39539 63334456
Tachycardia 28.71 11.00 334 114693 117822 63256173
Cell death 28.41 11.00 29 114998 2572 63371423
Macular degeneration 28.28 11.00 5 115022 24371 63349624
Product packaging confusion 28.21 11.00 11 115016 166 63373829
Hydrocephalus 28.12 11.00 41 114986 5259 63368736
Hypotonia neonatal 28.10 11.00 21 115006 1225 63372770
Product name confusion 28.09 11.00 9 115018 73 63373922
Temporal lobe epilepsy 27.82 11.00 14 115013 397 63373598
Abortion 27.58 11.00 28 114999 2468 63371527
Hypoaesthesia 27.11 11.00 186 114841 168207 63205788
Oropharyngeal oedema 26.94 11.00 13 115014 336 63373659
Pulmonary hypertension 26.89 11.00 17 115010 37106 63336889
Pregnancy on oral contraceptive 26.84 11.00 19 115008 1018 63372977
Device expulsion 26.69 11.00 15 115012 34907 63339088
Developmental regression 26.61 11.00 7 115020 25 63373970
Ultrasound ovary abnormal 26.60 11.00 9 115018 88 63373907
Amniotic band syndrome 26.58 11.00 5 115022 0 63373995
Hypertransaminasaemia 26.56 11.00 45 114982 6564 63367431
Loss of consciousness 26.55 11.00 329 114698 117792 63256203
Rhinorrhoea 26.43 11.00 49 114978 65528 63308467
Cytomegalovirus hepatitis 26.35 11.00 13 115014 353 63373642
Osteochondrosis 26.23 11.00 21 115006 1356 63372639
Product use issue 26.22 11.00 264 114763 220256 63153739
White matter lesion 26.10 11.00 24 115003 1871 63372124
Electrocardiogram QT prolonged 26.04 11.00 191 114836 59339 63314656
Oropharyngeal pain 26.02 11.00 86 114941 94401 63279594
Upper respiratory tract infection 25.96 11.00 70 114957 81977 63292018
Influenza 25.96 11.00 105 114922 108617 63265378
Opsoclonus myoclonus 25.88 11.00 10 115017 147 63373848
CSF measles antibody positive 25.87 11.00 8 115019 57 63373938
Erythema multiforme 25.81 11.00 57 114970 10112 63363883
Angiomyolipoma 25.80 11.00 11 115016 211 63373784
Fall 25.79 11.00 910 114117 391424 62982571
Hemianopia 25.73 11.00 19 115008 1088 63372907
Coma blister 25.70 11.00 10 115017 150 63373845
Anaemia 25.50 11.00 376 114651 293054 63080941
Headache 25.29 11.00 916 114111 632325 62741670
Psychomotor skills impaired 25.14 11.00 26 115001 2342 63371653
Psychomotor retardation 25.13 11.00 33 114994 3837 63370158
Ulcer 25.09 11.00 8 115019 26099 63347896
Rubella antibody positive 25.06 11.00 8 115019 64 63373931
Palpitations 25.02 11.00 112 114915 112658 63261337
Dry mouth 24.96 11.00 66 114961 77797 63296198
Grip strength decreased 24.94 11.00 5 115022 22282 63351713
Brain herniation 24.88 11.00 32 114995 3645 63370350
Magnetic resonance imaging head abnormal 24.87 11.00 24 115003 1989 63372006
Eosinophilic pneumonia 24.79 11.00 25 115002 2186 63371809
CSF protein increased 24.70 11.00 14 115013 507 63373488
Lethargy 24.67 11.00 180 114847 55827 63318168
Infantile apnoea 24.62 11.00 18 115009 1015 63372980
Hiccups 24.60 11.00 25 115002 2206 63371789
Neurosurgery 24.53 11.00 8 115019 69 63373926
Poor personal hygiene 24.52 11.00 12 115015 320 63373675
Basal cell carcinoma 24.48 11.00 10 115017 27981 63346014
Lymphopenia 24.45 11.00 81 114946 18246 63355749
Cleft lip 24.44 11.00 9 115018 115 63373880
Transaminases increased 24.33 11.00 117 114910 31250 63342745
Eye movement disorder 24.27 11.00 38 114989 5190 63368805
Autoimmune hepatitis 24.25 11.00 50 114977 8460 63365535
Paternal exposure before pregnancy 23.95 11.00 7 115020 40 63373955
Lymphangioleiomyomatosis 23.93 11.00 10 115017 182 63373813
Major depression 23.90 11.00 48 114979 7970 63366025
Respiratory failure 23.89 11.00 286 114741 101572 63272423
Axillary lymphadenectomy 23.65 11.00 5 115022 4 63373991
Gaze palsy 23.59 11.00 20 115007 1400 63372595
Lennox-Gastaut syndrome 23.46 11.00 11 115016 266 63373729
Acquired immunodeficiency syndrome 23.40 11.00 8 115019 81 63373914
Hypertonia 23.35 11.00 35 114992 4602 63369393
Aspiration 23.34 11.00 57 114970 10794 63363201
Heart rate irregular 23.15 11.00 6 115021 22415 63351580
Ear pain 22.95 11.00 19 115008 36099 63337896
Atrioventricular block complete 22.95 11.00 48 114979 8203 63365792
Type 2 diabetes mellitus 22.95 11.00 51 114976 63817 63310178
Catastrophic reaction 22.91 11.00 6 115021 21 63373974
Product residue present 22.91 11.00 32 114995 3947 63370048
Encephalomalacia 22.71 11.00 13 115014 480 63373515
Drowning 22.71 11.00 13 115014 480 63373515
Hydrops foetalis 22.70 11.00 14 115013 594 63373401
Juvenile myoclonic epilepsy 22.69 11.00 6 115021 22 63373973
Hot flush 22.66 11.00 36 114991 51123 63322872
Blood brain barrier defect 22.56 11.00 8 115019 91 63373904
Product prescribing error 22.56 11.00 101 114926 26188 63347807
Heart rate increased 22.50 11.00 91 114936 94147 63279848
Gamma-glutamyltransferase increased 22.25 11.00 121 114906 33910 63340085
Educational problem 22.24 11.00 12 115015 394 63373601
Unintended pregnancy 22.14 11.00 40 114987 6139 63367856
Cardiac arrest neonatal 22.10 11.00 8 115019 97 63373898
Premature labour 22.08 11.00 61 114966 12443 63361552
Ventricular fibrillation 22.07 11.00 59 114968 11808 63362187
Ocular hyperaemia 21.97 11.00 9 115018 25135 63348860
Glioma 21.95 11.00 11 115016 309 63373686
Inappropriate affect 21.95 11.00 16 115011 898 63373097
Bladder sphincter atony 21.94 11.00 9 115018 156 63373839
Anaplastic astrocytoma 21.71 11.00 7 115020 58 63373937
Impulsive behaviour 21.71 11.00 20 115007 1563 63372432
Metabolic acidosis 21.69 11.00 148 114879 44921 63329074
Haematoma 21.56 11.00 122 114905 34698 63339297
Pulmonary arterial hypertension 21.55 11.00 7 115020 22570 63351425
Tubulointerstitial nephritis 21.44 11.00 82 114945 19821 63354174
Hepatic cytolysis 21.37 11.00 69 114958 15338 63358657
Hemianopia homonymous 21.30 11.00 14 115013 664 63373331
Intestinal atresia 21.26 11.00 4 115023 0 63373995
Device dislocation 21.19 11.00 10 115017 25695 63348300
Accidental overdose 21.10 11.00 91 114936 23218 63350777
C-reactive protein increased 21.04 11.00 94 114933 94613 63279382
Bile acid malabsorption 21.04 11.00 9 115018 174 63373821
Quadriparesis 21.04 11.00 22 115005 2007 63371988
Unmasking of previously unidentified disease 21.01 11.00 16 115011 960 63373035
Dyspnoea exertional 20.98 11.00 49 114978 60253 63313742
Sinus bradycardia 20.94 11.00 66 114961 14485 63359510
Malabsorption 20.88 11.00 31 114996 4041 63369954
Automatism epileptic 20.78 11.00 5 115022 11 63373984
Burning sensation 20.76 11.00 42 114985 54365 63319630
Astrocytoma 20.55 11.00 7 115020 70 63373925
Motor dysfunction 20.51 11.00 54 114973 10707 63363288
Clonic convulsion 20.44 11.00 14 115013 711 63373284
Cerebral artery stenosis 20.37 11.00 12 115015 468 63373527
Haemorrhage intracranial 20.36 11.00 62 114965 13357 63360638
Inappropriate antidiuretic hormone secretion 20.32 11.00 68 114959 15394 63358601
Crying 20.27 11.00 90 114937 23253 63350742
Pregnancy on contraceptive 20.24 11.00 17 115010 1175 63372820
Intrauterine infection 20.20 11.00 8 115019 126 63373869
Chronic obstructive pulmonary disease 20.19 11.00 53 114974 62633 63311362
Petechiae 19.97 11.00 63 114964 13834 63360161
Central nervous system infection 19.91 11.00 14 115013 742 63373253
Euthyroid sick syndrome 19.87 11.00 7 115020 78 63373917
Neck pain 19.84 11.00 62 114965 69256 63304739
Wrong product administered 19.81 11.00 38 114989 6103 63367892
Subdural haematoma 19.72 11.00 64 114963 14264 63359731
Necrotising enterocolitis neonatal 19.65 11.00 9 115018 206 63373789
Mixed anxiety and depressive disorder 19.60 11.00 10 115017 292 63373703
Radiation necrosis 19.54 11.00 11 115016 393 63373602
Neurological decompensation 19.51 11.00 24 115003 2614 63371381
Eastern Cooperative Oncology Group performance status worsened 19.49 11.00 17 115010 1237 63372758
Illness 19.47 11.00 37 114990 49022 63324973
Lipids 19.43 11.00 5 115022 16 63373979
Ear malformation 19.38 11.00 9 115018 213 63373782
Eye pruritus 19.27 11.00 5 115022 18666 63355329
Gastric pH increased 19.25 11.00 6 115021 44 63373951
Normal newborn 19.22 11.00 45 114982 8296 63365699
Thunderclap headache 19.03 11.00 9 115018 222 63373773
Gestational diabetes 19.02 11.00 45 114982 8351 63365644
Eye irritation 18.97 11.00 8 115019 21963 63352032
Tendonitis 18.87 11.00 6 115021 19609 63354386
Rhesus incompatibility 18.76 11.00 7 115020 93 63373902
Right aortic arch 18.56 11.00 9 115018 235 63373760
Congenital spinal fusion 18.50 11.00 4 115023 4 63373991
Postictal paralysis 18.43 11.00 7 115020 98 63373897
Dystonia 18.37 11.00 61 114966 13758 63360237
Platelet count decreased 18.32 11.00 304 114723 115818 63258177
Musculoskeletal discomfort 18.19 11.00 5 115022 17962 63356033
Metastases to meninges 18.17 11.00 23 115004 2579 63371416
Exostosis 18.03 11.00 5 115022 17857 63356138
Echopraxia 18.00 11.00 5 115022 23 63373972
Cardiac arrest 17.97 11.00 251 114776 92294 63281701
Cardiac disorder 17.91 11.00 41 114986 50775 63323220
Craniotomy 17.89 11.00 9 115018 255 63373740
Localised infection 17.86 11.00 17 115010 30193 63343802
Irregular sleep phase 17.83 11.00 5 115022 24 63373971
Gastric disorder 17.81 11.00 25 115002 37344 63336651
Bone pain 17.75 11.00 46 114981 54595 63319400
Angina pectoris 17.70 11.00 17 115010 30061 63343934
Amnesia 17.69 11.00 166 114861 55419 63318576
Tooth disorder 17.66 11.00 15 115012 28142 63345853
Automatism 17.61 11.00 6 115021 60 63373935
Nodule 17.61 11.00 8 115019 21018 63352977
Cephalhaematoma 17.61 11.00 4 115023 6 63373989
Acquired macroglossia 17.59 11.00 8 115019 180 63373815
Nervous system disorder 17.56 11.00 74 114953 18692 63355303
Hypersomnia 17.52 11.00 72 114955 17983 63356012
Pyloric stenosis 17.50 11.00 10 115017 368 63373627
Hypernatraemia 17.48 11.00 41 114986 7568 63366427
Drug eruption 17.42 11.00 100 114927 28594 63345401
Spinal osteoarthritis 17.36 11.00 4 115023 16182 63357813
Disease progression 17.08 11.00 315 114712 122443 63251552
Breast cancer 17.08 11.00 39 114988 48344 63325651
Feeling abnormal 17.07 11.00 179 114848 148213 63225782
Lipids abnormal 17.01 11.00 9 115018 284 63373711
Hemiplegia 16.98 11.00 46 114981 9277 63364718
Cerebral cyst 16.95 11.00 9 115018 286 63373709
Haemoglobin decreased 16.94 11.00 175 114852 145310 63228685
Staphylococcal scalded skin syndrome 16.93 11.00 7 115020 124 63373871
Hypogammaglobulinaemia 16.92 11.00 39 114988 7116 63366879
Procedural pain 16.87 11.00 9 115018 21560 63352435
Placental disorder 16.85 11.00 17 115010 1487 63372508
Cyanosis neonatal 16.77 11.00 10 115017 399 63373596
Osteonecrosis 16.74 11.00 12 115015 24518 63349477
Severe myoclonic epilepsy of infancy 16.71 11.00 6 115021 71 63373924
Lymphangioma 16.63 11.00 5 115022 32 63373963
Febrile neutropenia 16.60 11.00 136 114891 118313 63255682
Amylase increased 16.59 11.00 36 114991 6309 63367686
Sudden infant death syndrome 16.56 11.00 9 115018 300 63373695
Ventricular hypokinesia 16.56 11.00 30 114997 4614 63369381
Language disorder 16.54 11.00 20 115007 2140 63371855
Drop attacks 16.52 11.00 12 115015 670 63373325
Drug dose titration not performed 16.50 11.00 11 115016 534 63373461
Injection site haemorrhage 16.45 11.00 12 115015 24302 63349693
Hyperhidrosis 16.42 11.00 121 114906 107715 63266280
Amniorrhexis 16.37 11.00 5 115022 34 63373961
Theft 16.34 11.00 6 115021 76 63373919
Tooth infection 16.34 11.00 6 115021 17914 63356081
Oscillopsia 16.34 11.00 7 115020 136 63373859
Cleft palate 16.29 11.00 14 115013 998 63372997
Polydactyly 16.24 11.00 9 115018 312 63373683
Premature rupture of membranes 16.23 11.00 31 114996 4962 63369033
Throat irritation 16.19 11.00 27 115000 37620 63336375
Precocious puberty 16.12 11.00 8 115019 220 63373775
Intrusive thoughts 16.12 11.00 8 115019 220 63373775
Injection site urticaria 16.08 11.00 3 115024 14070 63359925
Pregnancy with implant contraceptive 16.08 11.00 22 115005 2661 63371334
Abortion threatened 16.02 11.00 11 115016 561 63373434
Injection site rash 16.00 11.00 7 115020 18802 63355193
Nail dystrophy 15.93 11.00 14 115013 1029 63372966
Respiratory syncytial virus bronchiolitis 15.88 11.00 9 115018 326 63373669
Paraesthesia 15.84 11.00 195 114832 156771 63217224
Congenital arterial malformation 15.83 11.00 9 115018 328 63373667
Injection site warmth 15.82 11.00 4 115023 15191 63358804
Vertigo 15.77 11.00 172 114855 59715 63314280
Diabetes mellitus inadequate control 15.71 11.00 4 115023 15122 63358873
Mitochondrial cytopathy 15.52 11.00 8 115019 239 63373756
Anticonvulsant drug level abnormal 15.45 11.00 5 115022 42 63373953
Injection site bruising 15.44 11.00 33 114994 41877 63332118
Hostility 15.44 11.00 18 115009 1854 63372141
Refusal of treatment by patient 15.31 11.00 32 114995 5465 63368530
Herpes simplex encephalitis 15.30 11.00 9 115018 350 63373645
Depressive symptom 15.27 11.00 27 115000 4075 63369920
Urinary tract stoma complication 15.24 11.00 5 115022 44 63373951
Dementia 15.23 11.00 71 114956 18723 63355272
Microcephaly 15.13 11.00 13 115014 927 63373068
Lower limb fracture 15.07 11.00 13 115014 24208 63349787
Abulia 15.05 11.00 10 115017 483 63373512
Hepatic function abnormal 15.02 11.00 117 114910 37025 63336970
Condition aggravated 15.01 11.00 881 114146 401336 62972659
Ear infection 15.01 11.00 29 114998 38184 63335811
Vascular graft infection 14.95 11.00 5 115022 47 63373948
Nosocomial infection 14.95 11.00 17 115010 1704 63372291
Haemoptysis 14.94 11.00 18 115009 28708 63345287
Mucocutaneous rash 14.85 11.00 4 115023 16 63373979
Blood pressure diastolic abnormal 14.81 11.00 4 115023 14538 63359457
Pulmonary valve stenosis congenital 14.72 11.00 7 115020 175 63373820
Dysgeusia 14.66 11.00 40 114987 46670 63327325
Device malfunction 14.64 11.00 7 115020 17850 63356145
Lactation disorder 14.61 11.00 9 115018 381 63373614
Glycosuria 14.59 11.00 14 115013 1152 63372843
Intensive care unit delirium 14.59 11.00 5 115022 51 63373944
Hypocalcaemia 14.59 11.00 103 114924 31610 63342385
Oral pain 14.55 11.00 18 115009 28376 63345619
Diabetes mellitus 14.54 11.00 52 114975 55758 63318237
Intensive care unit acquired weakness 14.54 11.00 12 115015 809 63373186
Congenital anomaly 14.52 11.00 17 115010 1759 63372236
Brain neoplasm malignant 14.49 11.00 14 115013 1162 63372833
Carpal tunnel syndrome 14.44 11.00 10 115017 20807 63353188
Withdrawal syndrome 14.38 11.00 73 114954 19924 63354071
Food interaction 14.33 11.00 12 115015 826 63373169
Emotional disorder 14.31 11.00 55 114972 13324 63360671
Labelled drug-drug interaction medication error 14.26 11.00 55 114972 13344 63360651
Urine amphetamine positive 14.25 11.00 5 115022 55 63373940
Asterixis 14.21 11.00 15 115012 1384 63372611
Chills 14.19 11.00 134 114893 113244 63260751
Psychiatric decompensation 14.19 11.00 15 115012 1386 63372609
Hiatus hernia 14.17 11.00 11 115016 21583 63352412
Placenta praevia 14.17 11.00 13 115014 1011 63372984
Threatened labour 14.13 11.00 12 115015 842 63373153
Coma acidotic 14.12 11.00 6 115021 114 63373881
Laryngomalacia 14.01 11.00 5 115022 58 63373937
Intracranial hypotension 13.96 11.00 8 115019 296 63373699
Gastrointestinal haemorrhage 13.89 11.00 88 114939 81088 63292907
Cerebrosclerosis 13.87 11.00 3 115024 3 63373992
Bronchiectasis 13.74 11.00 6 115021 16136 63357859
Acute disseminated encephalomyelitis 13.70 11.00 7 115020 205 63373790
Paraesthesia oral 13.70 11.00 9 115018 19247 63354748
Placental infarction 13.69 11.00 8 115019 307 63373688
Illusion 13.68 11.00 13 115014 1057 63372938
Primary mediastinal large B-cell lymphoma 13.67 11.00 4 115023 23 63373972
Brain abscess 13.66 11.00 18 115009 2100 63371895
Sialoadenitis 13.66 11.00 16 115011 1656 63372339
Illogical thinking 13.64 11.00 5 115022 63 63373932
Vasogenic cerebral oedema 13.63 11.00 12 115015 884 63373111
General physical health deterioration 13.61 11.00 270 114757 201132 63172863
Laryngeal stenosis 13.60 11.00 13 115014 1065 63372930
Throat tightness 13.58 11.00 15 115012 24872 63349123
Postmature baby 13.57 11.00 6 115021 126 63373869
Multiple sclerosis 13.55 11.00 83 114944 24289 63349706
Cerebral atrophy 13.54 11.00 29 114998 5037 63368958
Sinus congestion 13.54 11.00 8 115019 18115 63355880
Neonatal disorder 13.54 11.00 10 115017 573 63373422
Epilepsy surgery 13.52 11.00 4 115023 24 63373971
Plasma cell myeloma 13.45 11.00 28 114999 35877 63338118
Atrial septal defect 13.41 11.00 35 114992 6903 63367092
Cerebellar atrophy 13.39 11.00 11 115016 737 63373258
QRS axis abnormal 13.32 11.00 13 115014 1092 63372903
Sinus arrest 13.25 11.00 17 115010 1932 63372063
Weight decreased 13.23 11.00 391 114636 276407 63097588
Blood glucose increased 13.23 11.00 93 114934 83663 63290332
Rotator cuff syndrome 13.22 11.00 4 115023 13498 63360497
Drug exposure before pregnancy 13.20 11.00 12 115015 922 63373073
Drug level below therapeutic 13.18 11.00 28 114999 4838 63369157
Respiratory tract congestion 13.14 11.00 8 115019 17824 63356171
Radiation skin injury 13.10 11.00 12 115015 931 63373064
Sleep disorder due to a general medical condition 13.10 11.00 3 115024 12185 63361810
Wrong patient 13.08 11.00 7 115020 226 63373769
Congenital central nervous system anomaly 13.04 11.00 8 115019 336 63373659
Cerebral haemorrhage neonatal 12.99 11.00 6 115021 140 63373855
High-pitched crying 12.99 11.00 4 115023 28 63373967
Hepatitis viral 12.95 11.00 9 115018 468 63373527
Blood lactic acid increased 12.94 11.00 35 114992 7051 63366944
Balance disorder 12.94 11.00 220 114807 84202 63289793
Attention-seeking behaviour 12.85 11.00 5 115022 75 63373920
Infantile haemangioma 12.85 11.00 5 115022 75 63373920
Mitral valve incompetence 12.83 11.00 10 115017 19584 63354411
Product administered to patient of inappropriate age 12.80 11.00 22 115005 3246 63370749
Diverticulum 12.79 11.00 3 115024 11988 63362007
Arteriovenous malformation 12.79 11.00 14 115013 1346 63372649
Lip dry 12.78 11.00 6 115021 15464 63358531
Adverse event 12.74 11.00 71 114956 67488 63306507
Blood creatinine increased 12.70 11.00 100 114927 87744 63286251
Developmental hip dysplasia 12.69 11.00 14 115013 1358 63372637
Shunt malfunction 12.67 11.00 5 115022 78 63373917
Glycogen storage disorder 12.66 11.00 3 115024 6 63373989
Therapeutic response shortened 12.63 11.00 3 115024 11885 63362110
Teratoma 12.62 11.00 6 115021 150 63373845
Systemic inflammatory response syndrome 12.60 11.00 30 114997 5591 63368404
Perforation 12.58 11.00 13 115014 1170 63372825
Rectal haemorrhage 12.57 11.00 46 114981 48984 63325011
Systolic dysfunction 12.56 11.00 15 115012 1584 63372411
Dyscalculia 12.51 11.00 6 115021 153 63373842
Motor developmental delay 12.47 11.00 6 115021 154 63373841
Polychromasia 12.47 11.00 6 115021 154 63373841
Asthenia 12.45 11.00 568 114459 383036 62990959
Catatonia 12.40 11.00 26 115001 4451 63369544
Accessory auricle 12.35 11.00 3 115024 7 63373988
Premature separation of placenta 12.29 11.00 16 115011 1845 63372150
Neonatal seizure 12.22 11.00 9 115018 513 63373482
Rebound effect 12.20 11.00 26 115001 4500 63369495
Carnitine deficiency 12.19 11.00 6 115021 162 63373833
Eye pain 12.19 11.00 27 115000 33827 63340168
Papilloedema 12.16 11.00 24 115003 3936 63370059
Sinus disorder 12.13 11.00 16 115011 24537 63349458
Anotia 12.06 11.00 3 115024 8 63373987
Blood pressure diastolic decreased 12.05 11.00 14 115013 22692 63351303
Coma hepatic 12.01 11.00 10 115017 683 63373312
Skin disorder 11.93 11.00 22 115005 29485 63344510
Tongue injury 11.90 11.00 8 115019 394 63373601
Adverse drug reaction 11.87 11.00 90 114937 79624 63294371
Mental impairment 11.87 11.00 54 114973 14097 63359898
Disorganised speech 11.86 11.00 13 115014 1252 63372743
Surgery 11.84 11.00 30 114997 35882 63338113
Vasoplegia syndrome 11.83 11.00 15 115012 1684 63372311
Obstructive airways disorder 11.83 11.00 12 115015 20687 63353308
Osteomyelitis 11.82 11.00 18 115009 26002 63347993
Frontal lobe epilepsy 11.80 11.00 3 115024 9 63373986
Intestinal ischaemia 11.80 11.00 35 114992 7433 63366562
Clonus 11.78 11.00 26 115001 4610 63369385
Taste disorder 11.76 11.00 5 115022 13657 63360338
Intervertebral disc degeneration 11.68 11.00 7 115020 15725 63358270
Optic nerve disorder 11.64 11.00 11 115016 888 63373107
B-lymphocyte count decreased 11.59 11.00 12 115015 1082 63372913
Wound infection 11.58 11.00 13 115014 21397 63352598
Hyporesponsive to stimuli 11.50 11.00 12 115015 1092 63372903
Femur fracture 11.49 11.00 38 114989 41718 63332277
Interleukin level increased 11.46 11.00 8 115019 419 63373576
Amniocentesis abnormal 11.44 11.00 5 115022 102 63373893
Faeces discoloured 11.44 11.00 10 115017 18499 63355496
Bronchiolitis 11.43 11.00 19 115008 2728 63371267
Electrocardiogram repolarisation abnormality 11.43 11.00 13 115014 1304 63372691
Anti-GAD antibody positive 11.40 11.00 4 115023 44 63373951
Multiple congenital abnormalities 11.38 11.00 9 115018 571 63373424
Paraparesis 11.36 11.00 17 115010 2231 63371764
Blood calcium decreased 11.35 11.00 19 115008 26432 63347563
Dysphonia 11.35 11.00 46 114981 47568 63326427
Gliosis 11.28 11.00 7 115020 300 63373695
Nail infection 11.24 11.00 18 115009 2505 63371490
Growth retardation 11.23 11.00 13 115014 1328 63372667
Thrombosis 11.18 11.00 70 114957 64685 63309310
Sputum discoloured 11.15 11.00 8 115019 16339 63357656
Resuscitation 11.15 11.00 12 115015 1132 63372863
Biopsy brain 11.14 11.00 3 115024 12 63373983
Toe walking 11.14 11.00 3 115024 12 63373983
Coordination abnormal 11.14 11.00 52 114975 13721 63360274
Brain injury 11.12 11.00 33 114994 7010 63366985
Psychotic behaviour 11.11 11.00 9 115018 591 63373404
Hypotension 11.10 11.00 602 114425 272002 63101993
Bronchospasm 11.09 11.00 9 115018 17271 63356724
Anaphylactic shock 11.07 11.00 16 115011 23617 63350378
Cerebral disorder 11.07 11.00 25 115002 4501 63369494
Cold sweat 11.04 11.00 4 115023 12043 63361952
Foetal malformation 11.04 11.00 6 115021 200 63373795

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 4094.71 10.94 2913 95183 101944 34756891
Status epilepticus 1770.37 10.94 812 97284 11802 34847033
Generalised tonic-clonic seizure 1009.66 10.94 668 97428 20506 34838329
Epilepsy 931.23 10.94 639 97457 20856 34837979
Multiple-drug resistance 727.49 10.94 335 97761 4904 34853931
Partial seizures 688.06 10.94 313 97783 4447 34854388
Aggression 530.34 10.94 599 97497 38365 34820470
Drug ineffective 496.98 10.94 2554 95542 454197 34404638
Foetal exposure during pregnancy 424.66 10.94 529 97567 37572 34821263
Product substitution issue 413.22 10.94 290 97806 9805 34849030
Somnolence 312.68 10.94 847 97249 110269 34748566
Drug reaction with eosinophilia and systemic symptoms 309.55 10.94 421 97675 32591 34826244
Dyspnoea 304.44 10.94 367 97729 376415 34482420
Psychogenic seizure 247.46 10.94 75 98021 293 34858542
Cytokine release syndrome 237.92 10.94 307 97789 22570 34836265
Maternal exposure during pregnancy 236.22 10.94 156 97940 4762 34854073
Focal dyscognitive seizures 228.98 10.94 100 97996 1281 34857554
Cognitive disorder 202.36 10.94 320 97776 28373 34830462
Petit mal epilepsy 196.61 10.94 117 97979 2961 34855874
Encephalopathy 189.76 10.94 349 97747 34970 34823865
Irritability 187.59 10.94 285 97811 24405 34834430
Rhabdomyolysis 185.90 10.94 514 97582 67649 34791186
Myocardial infarction 185.05 10.94 55 98041 121030 34737805
Drug withdrawal convulsions 184.71 10.94 82 98014 1095 34857740
Behaviour disorder 175.62 10.94 130 97966 4780 34854055
Agitation 171.77 10.94 448 97648 56951 34801884
Aura 168.64 10.94 55 98041 287 34858548
Arthralgia 167.31 10.94 139 97957 169902 34688933
Hyperammonaemia 164.10 10.94 139 97957 6228 34852607
Aphasia 160.65 10.94 246 97850 21208 34837627
Myoclonic epilepsy 160.63 10.94 74 98022 1083 34857752
Sudden unexplained death in epilepsy 150.61 10.94 55 98041 423 34858412
Ataxia 148.88 10.94 189 97907 13664 34845171
Abnormal behaviour 148.55 10.94 258 97838 24711 34834124
Postictal psychosis 147.42 10.94 44 98052 161 34858674
Myoclonus 142.84 10.94 191 97905 14534 34844301
Diarrhoea 137.98 10.94 595 97501 389317 34469518
Immune effector cell-associated neurotoxicity syndrome 136.61 10.94 100 97996 3613 34855222
Drug resistance 130.27 10.94 249 97847 25678 34833157
Maternal drugs affecting foetus 122.04 10.94 96 98000 3869 34854966
Electroencephalogram abnormal 119.96 10.94 79 98017 2399 34856436
Pain 116.95 10.94 250 97846 204425 34654410
Cardiac failure congestive 116.39 10.94 44 98052 83226 34775609
Tonic convulsion 116.15 10.94 60 98036 1141 34857694
Hepatocellular injury 113.67 10.94 215 97881 21996 34836839
Glioblastoma 111.41 10.94 56 98040 1003 34857832
Confusional state 110.19 10.94 737 97359 143423 34715412
Developmental delay 104.96 10.94 76 98020 2699 34856136
Anticonvulsant drug level increased 104.70 10.94 62 98034 1554 34857281
Seizure cluster 103.32 10.94 31 98065 116 34858719
Chest pain 99.22 10.94 126 97970 126636 34732199
Anticonvulsant drug level decreased 98.31 10.94 52 98044 1040 34857795
Back pain 96.42 10.94 120 97976 121669 34737166
Delirium 96.31 10.94 307 97789 43684 34815151
No adverse event 95.85 10.94 204 97892 22723 34836112
Change in seizure presentation 95.78 10.94 30 98066 134 34858701
Pain in extremity 93.67 10.94 131 97965 126382 34732453
Anticonvulsant drug level above therapeutic 92.74 10.94 43 98053 639 34858196
Hemiparesis 92.49 10.94 162 97934 15616 34843219
Infantile spasms 92.44 10.94 31 98065 179 34858656
Exposure via breast milk 92.28 10.94 62 98034 1948 34856887
Rheumatoid arthritis 90.20 10.94 4 98092 38234 34820601
Drug ineffective for unapproved indication 86.72 10.94 200 97896 23515 34835320
Anger 85.77 10.94 134 97962 11750 34847085
Malaise 84.41 10.94 255 97841 185570 34673265
Joint swelling 83.08 10.94 32 98064 59858 34798977
Brain malformation 82.45 10.94 27 98069 143 34858692
Coronary artery disease 81.28 10.94 18 98078 48287 34810548
Pneumonia aspiration 80.65 10.94 280 97816 41623 34817212
Premature baby 80.12 10.94 173 97923 19460 34839375
Thrombocytopenia 79.50 10.94 727 97369 155520 34703315
Encephalitis autoimmune 79.26 10.94 39 98057 666 34858169
Atrial fibrillation 78.93 10.94 139 97957 122254 34736581
Brain oedema 78.54 10.94 140 97956 13681 34845154
Anticonvulsant drug level below therapeutic 76.36 10.94 37 98059 610 34858225
Atrial septal defect 74.94 10.94 98 97998 7294 34851541
Partial seizures with secondary generalisation 74.75 10.94 30 98066 306 34858529
Stupor 74.26 10.94 63 98033 2828 34856007
Hyperammonaemic encephalopathy 70.95 10.94 56 98040 2268 34856567
Nausea 70.86 10.94 612 97484 339296 34519539
Cough 68.16 10.94 206 97890 149934 34708901
Neurological decompensation 66.86 10.94 60 98036 2906 34855929
Low birth weight baby 66.85 10.94 96 98000 7809 34851026
Stevens-Johnson syndrome 65.74 10.94 155 97941 18484 34840351
Rash maculo-papular 65.42 10.94 202 97894 28249 34830586
Eosinophilia 64.84 10.94 191 97905 26031 34832804
Prostate cancer 64.28 10.94 16 98080 39633 34819202
Off label use 63.89 10.94 1583 96513 417941 34440894
Abdominal pain 63.70 10.94 240 97856 163378 34695457
Psychotic disorder 63.24 10.94 181 97915 24271 34834564
Glioblastoma multiforme 63.22 10.94 34 98062 704 34858131
Small for dates baby 63.17 10.94 66 98030 3861 34854974
Cholestasis 62.59 10.94 192 97904 26756 34832079
Nystagmus 61.54 10.94 71 98025 4644 34854191
Brain neoplasm 60.92 10.94 59 98037 3150 34855685
Neuropathy peripheral 60.81 10.94 87 98009 83176 34775659
Chest discomfort 60.77 10.94 39 98057 54491 34804344
Ventricular septal defect 60.38 10.94 65 98031 3936 34854899
Drug interaction 60.36 10.94 929 97167 225017 34633818
Psychiatric symptom 58.23 10.94 60 98036 3453 34855382
Hypotonia neonatal 58.21 10.94 40 98056 1305 34857530
Anaemia 56.99 10.94 402 97694 232933 34625902
Toxic epidermal necrolysis 56.73 10.94 161 97935 21485 34837350
COVID-19 56.66 10.94 81 98015 77469 34781366
Cryptorchism 55.57 10.94 46 98050 1995 34856840
Neurotoxicity 55.28 10.94 142 97954 17868 34840967
Paradoxical drug reaction 55.13 10.94 57 98039 3294 34855541
Death 54.98 10.94 787 97309 397262 34461573
Simple partial seizures 54.52 10.94 23 98073 269 34858566
Dysmorphism 54.31 10.94 55 98041 3101 34855734
Memory impairment 54.09 10.94 253 97843 43065 34815770
Gastrointestinal haemorrhage 53.89 10.94 104 97992 88373 34770462
Acute myocardial infarction 53.87 10.94 43 98053 53676 34805159
Drug level decreased 53.21 10.94 86 98010 7760 34851075
Affective disorder 52.50 10.94 63 98033 4297 34854538
Sedation 51.92 10.94 153 97943 20853 34837982
Chronic obstructive pulmonary disease 51.82 10.94 37 98059 48881 34809954
Brain operation 51.15 10.94 23 98073 317 34858518
Pneumonia 51.09 10.94 714 97382 361913 34496922
Overdose 51.06 10.94 433 97663 90626 34768209
Oedema peripheral 50.43 10.94 170 97926 119642 34739193
Mood altered 49.99 10.94 90 98006 8862 34849973
Coordination abnormal 49.43 10.94 82 98014 7562 34851273
Atonic seizures 49.37 10.94 21 98075 251 34858584
Cerebral cyst 49.27 10.94 22 98074 298 34858537
Acute psychosis 49.06 10.94 41 98055 1802 34857033
Psychomotor hyperactivity 49.04 10.94 93 98003 9529 34849306
Febrile convulsion 48.50 10.94 27 98069 600 34858235
Disorientation 48.37 10.94 203 97893 32985 34825850
Arthritis 48.26 10.94 14 98082 31332 34827503
Myalgia 47.71 10.94 103 97993 84007 34774828
Cardiac failure 47.52 10.94 117 97979 91131 34767704
Gaze palsy 47.48 10.94 39 98057 1673 34857162
Diabetes insipidus 46.72 10.94 49 98047 2879 34855956
Glomerulonephritis minimal lesion 45.96 10.94 24 98072 467 34858368
Blood pressure increased 45.85 10.94 113 97983 87989 34770846
Personality change 45.81 10.94 64 98032 5075 34853760
Altered state of consciousness 45.80 10.94 155 97941 22738 34836097
Abdominal discomfort 45.20 10.94 61 98035 59774 34799061
Clonic convulsion 44.76 10.94 26 98070 628 34858207
Cardiogenic shock 44.61 10.94 10 98086 26608 34832227
Hamartoma 44.56 10.94 13 98083 43 34858792
Dyspnoea exertional 44.20 10.94 34 98062 43245 34815590
Selective eating disorder 44.15 10.94 38 98058 1740 34857095
Hypoventilation neonatal 43.91 10.94 9 98087 0 34858835
Suicidal ideation 43.38 10.94 226 97870 40162 34818673
Meningitis aseptic 42.83 10.94 49 98047 3175 34855660
Speech disorder developmental 42.80 10.94 41 98055 2159 34856676
Melaena 42.68 10.94 23 98073 35357 34823478
Irregular sleep phase 42.26 10.94 13 98083 54 34858781
Urethral atresia 41.64 10.94 11 98085 22 34858813
Angina pectoris 41.47 10.94 18 98078 31345 34827490
Blood creatinine increased 41.16 10.94 133 97963 94843 34763992
Psoriatic arthropathy 41.05 10.94 4 98092 19794 34839041
Abdominal pain upper 40.99 10.94 87 98009 71403 34787432
Haemoglobin decreased 40.83 10.94 187 97909 120585 34738250
Neonatal pneumonia 40.56 10.94 15 98081 120 34858715
Febrile neutropenia 40.50 10.94 222 97874 136627 34722208
Psoriasis 40.27 10.94 30 98066 38782 34820053
Muscle twitching 40.03 10.94 89 98007 10209 34848626
Posterior reversible encephalopathy syndrome 39.79 10.94 87 98009 9867 34848968
Interstitial lung disease 39.51 10.94 77 98019 65205 34793630
Depressed level of consciousness 39.50 10.94 230 97866 42611 34816224
Autonomic nervous system imbalance 39.48 10.94 42 98054 2509 34856326
Condition aggravated 39.22 10.94 757 97339 191439 34667396
Polydactyly 38.70 10.94 30 98066 1183 34857652
Haemophagocytic lymphohistiocytosis 38.49 10.94 101 97995 12872 34845963
Convulsive threshold lowered 38.45 10.94 22 98074 516 34858319
Chills 38.33 10.94 109 97987 80934 34777901
Drug withdrawal syndrome neonatal 38.28 10.94 49 98047 3570 34855265
Foetal megacystis 38.03 10.94 11 98085 35 34858800
Pruritus 37.93 10.94 238 97858 141743 34717092
Cardiac disorder 37.89 10.94 39 98057 43087 34815748
Pleural effusion 37.60 10.94 111 97985 81435 34777400
Gait disturbance 37.24 10.94 384 97712 84756 34774079
Accidental death 37.24 10.94 40 98056 2416 34856419
Hyponatraemia 37.15 10.94 375 97721 82316 34776519
Hallucination, visual 36.96 10.94 122 97974 17669 34841166
Injection site pain 36.92 10.94 33 98063 38972 34819863
Plasmapheresis 36.34 10.94 18 98078 312 34858523
Arthropathy 36.28 10.94 15 98081 26892 34831943
Fluid retention 36.24 10.94 15 98081 26872 34831963
Eye movement disorder 36.19 10.94 51 98045 4076 34854759
Propofol infusion syndrome 35.50 10.94 26 98070 940 34857895
Mental status changes 35.46 10.94 205 97891 37878 34820957
Necrosis ischaemic 35.37 10.94 17 98079 275 34858560
Neonatal infection 35.13 10.94 19 98077 398 34858437
Asthenia 35.13 10.94 481 97615 244770 34614065
Excessive eye blinking 35.05 10.94 21 98075 538 34858297
Hyperhidrosis 34.92 10.94 103 97993 75589 34783246
Asthma 34.80 10.94 41 98055 42615 34816220
Suicide attempt 34.77 10.94 208 97888 38908 34819927
Gliosis 34.56 10.94 15 98081 189 34858646
Infusion related reaction 34.40 10.94 60 98036 52997 34805838
Maternal exposure during breast feeding 34.39 10.94 31 98065 1510 34857325
Attention deficit hyperactivity disorder 34.18 10.94 39 98057 2520 34856315
Tubulointerstitial nephritis 34.14 10.94 133 97963 20891 34837944
Intensive care unit acquired weakness 34.08 10.94 26 98070 1001 34857834
Plasma cell myeloma 33.67 10.94 41 98055 41996 34816839
Hydrocephalus 33.66 10.94 56 98040 5176 34853659
Ascites 33.65 10.94 49 98047 46522 34812313
Staring 33.65 10.94 30 98066 1440 34857395
Oculogyric crisis 33.62 10.94 31 98065 1555 34857280
Sinusitis 33.56 10.94 40 98056 41362 34817473
Inappropriate antidiuretic hormone secretion 33.55 10.94 95 98001 12658 34846177
Congenital hypoplasia of depressor angularis oris muscle 33.51 10.94 8 98088 8 34858827
Disturbance in attention 33.46 10.94 153 97943 25792 34833043
Non-24-hour sleep-wake disorder 33.43 10.94 9 98087 20 34858815
Peripheral swelling 33.29 10.94 107 97989 76434 34782401
Blood glucose increased 32.84 10.94 88 98008 66630 34792205
Speech disorder 32.78 10.94 151 97945 25535 34833300
Haemoptysis 32.67 10.94 30 98066 34976 34823859
Mood swings 32.66 10.94 70 98026 7831 34851004
Productive cough 32.32 10.94 35 98061 37778 34821057
Coma blister 32.04 10.94 11 98085 69 34858766
Vesicoureteric reflux 31.87 10.94 14 98082 182 34858653
Balance disorder 31.66 10.94 209 97887 40445 34818390
Hypothermia 31.20 10.94 83 98013 10665 34848170
International normalised ratio increased 31.16 10.94 53 98043 47274 34811561
Postictal state 31.10 10.94 23 98073 844 34857991
Neonatal hypotension 31.05 10.94 13 98083 149 34858686
Metastases to central nervous system 30.87 10.94 70 98026 8135 34850700
Postictal paralysis 30.86 10.94 15 98081 249 34858586
Renal failure 30.81 10.94 227 97869 130330 34728505
Depressive symptom 30.70 10.94 39 98057 2820 34856015
Treatment noncompliance 30.70 10.94 158 97938 27942 34830893
Maternal exposure before pregnancy 30.68 10.94 22 98074 769 34858066
Hypospadias 30.24 10.94 41 98055 3160 34855675
Hypotonia 29.55 10.94 67 98029 7786 34851049
Hyperkalaemia 29.48 10.94 98 97998 69291 34789544
Temporal lobe epilepsy 29.45 10.94 13 98083 171 34858664
Autism spectrum disorder 29.00 10.94 34 98062 2262 34856573
Infantile apnoea 29.00 10.94 23 98073 938 34857897
Impulsive behaviour 28.96 10.94 33 98063 2129 34856706
Congenital nail disorder 28.95 10.94 9 98087 39 34858796
Failure to suspend medication 28.89 10.94 17 98079 421 34858414
Influenza 28.84 10.94 60 98036 49606 34809229
Synovitis 28.75 10.94 3 98093 14063 34844772
Cerebellar ataxia 28.73 10.94 24 98072 1054 34857781
Lymphopenia 28.72 10.94 106 97990 16229 34842606
Pulmonary fibrosis 28.72 10.94 8 98088 18388 34840447
Acidosis hyperchloraemic 28.71 10.94 17 98079 426 34858409
Product administration error 28.68 10.94 106 97990 16238 34842597
Syndactyly 28.63 10.94 22 98074 856 34857979
Anaphylactic reaction 28.61 10.94 29 98067 32272 34826563
Hypertension 28.60 10.94 245 97851 136198 34722637
Nasopharyngitis 28.25 10.94 101 97995 69867 34788968
Blood pressure fluctuation 28.20 10.94 18 98078 25231 34833604
Nicotinic acid deficiency 28.05 10.94 11 98085 105 34858730
Blood creatine phosphokinase increased 27.64 10.94 218 97878 44639 34814196
Delusion 27.47 10.94 88 98008 12547 34846288
Suicidal behaviour 27.44 10.94 27 98069 1470 34857365
Respiratory disorder neonatal 27.31 10.94 28 98068 1602 34857233
Dyskinesia 27.31 10.94 130 97966 22283 34836552
Organic brain syndrome 27.30 10.94 14 98082 262 34858573
Encephalitis 27.29 10.94 62 98034 7215 34851620
Stress 27.16 10.94 27 98069 30320 34828515
Neonatal respiratory distress syndrome 27.06 10.94 44 98052 3990 34854845
Single umbilical artery 26.95 10.94 13 98083 212 34858623
Diabetes mellitus 26.90 10.94 57 98039 46816 34812019
Nasal septum disorder 26.83 10.94 9 98087 52 34858783
Thrombosis 26.80 10.94 64 98032 50394 34808441
Constipation 26.51 10.94 251 97845 136731 34722104
Mucosal ulceration 26.21 10.94 22 98074 973 34857862
Anencephaly 26.12 10.94 11 98085 128 34858707
Muscle spasms 26.01 10.94 115 97981 74886 34783949
Developmental regression 25.86 10.94 8 98088 34 34858801
Blepharospasm 25.61 10.94 23 98073 1115 34857720
Postmature baby 25.57 10.94 7 98089 17 34858818
Paraplegia 25.57 10.94 36 98060 2875 34855960
Weight decreased 25.49 10.94 345 97751 175956 34682879
Bradyphrenia 25.23 10.94 47 98049 4751 34854084
Pulmonary embolism 25.22 10.94 148 97948 89598 34769237
Leukopenia 24.91 10.94 278 97818 62578 34796257
Wheezing 24.90 10.94 49 98047 41353 34817482
Epileptic encephalopathy 24.86 10.94 12 98084 196 34858639
Burnout syndrome 24.83 10.94 11 98085 146 34858689
Acoustic stimulation tests abnormal 24.67 10.94 9 98087 69 34858766
Abdominal distension 24.58 10.94 83 98013 58409 34800426
Anomaly of external ear congenital 24.58 10.94 10 98086 106 34858729
Bradycardia neonatal 24.52 10.94 21 98075 955 34857880
Cerebral haemorrhage 24.47 10.94 175 97921 34762 34824073
Cerebral atrophy 24.45 10.94 45 98051 4507 34854328
Drop attacks 24.43 10.94 17 98079 566 34858269
Contraindicated product administered 24.43 10.94 15 98081 21466 34837369
Frontal lobe epilepsy 24.39 10.94 5 98091 0 34858835
Idiopathic generalised epilepsy 24.33 10.94 8 98088 43 34858792
Terminal insomnia 24.30 10.94 17 98079 571 34858264
Intellectual disability 24.28 10.94 24 98072 1314 34857521
Administration site discomfort 24.03 10.94 8 98088 45 34858790
Gout 23.98 10.94 12 98084 19241 34839594
Appendicitis 23.95 10.94 6 98090 14801 34844034
Eastern Cooperative Oncology Group performance status worsened 23.93 10.94 21 98075 987 34857848
Neonatal tachypnoea 23.81 10.94 11 98085 162 34858673
Limb reduction defect 23.80 10.94 13 98083 278 34858557
Foetal growth restriction 23.77 10.94 42 98054 4075 34854760
Prostatic specific antigen increased 23.64 10.94 6 98090 14674 34844161
Brain abscess 23.61 10.94 36 98060 3089 34855746
Limbic encephalitis 23.60 10.94 15 98081 428 34858407
Laboratory test abnormal 23.52 10.94 14 98082 20377 34838458
Bronchitis 23.28 10.94 52 98044 41911 34816924
Affect lability 23.13 10.94 39 98057 3644 34855191
Language disorder 23.01 10.94 30 98066 2226 34856609
Lung disorder 22.70 10.94 39 98057 34657 34824178
Congenital hydrocephalus 22.67 10.94 9 98087 89 34858746
Poor sucking reflex 22.53 10.94 13 98083 310 34858525
Hallucination, auditory 22.37 10.94 79 98017 11838 34846997
Purple glove syndrome 22.31 10.94 8 98088 58 34858777
Cardiopulmonary failure 22.29 10.94 41 98055 4104 34854731
Wrong patient received product 22.10 10.94 32 98064 2622 34856213
Intracranial tumour haemorrhage 22.09 10.94 13 98083 322 34858513
Ammonia increased 21.98 10.94 42 98054 4327 34854508
Neuropsychiatric symptoms 21.83 10.94 19 98077 883 34857952
Altered pitch perception 21.80 10.94 6 98090 15 34858820
Parkinsonism 21.78 10.94 61 98035 8077 34850758
Ehlers-Danlos syndrome 21.71 10.94 7 98089 35 34858800
Drug abuse 21.63 10.94 176 97920 98920 34759915
Thinking abnormal 21.60 10.94 51 98045 6086 34852749
Sepsis 21.59 10.94 333 97763 166228 34692607
Aplastic anaemia 21.42 10.94 68 98028 9648 34849187
Slow response to stimuli 21.33 10.94 18 98078 802 34858033
Persecutory delusion 21.33 10.94 31 98065 2549 34856286
Chronic kidney disease 21.31 10.94 53 98043 41157 34817678
Personality disorder 21.29 10.94 21 98075 1147 34857688
Hypertransaminasaemia 21.28 10.94 48 98048 5558 34853277
Toxic encephalopathy 21.12 10.94 46 98050 5203 34853632
Osteonecrosis of jaw 21.03 10.94 12 98084 17877 34840958
Misleading laboratory test result 21.01 10.94 6 98090 18 34858817
Rash scarlatiniform 20.98 10.94 9 98087 110 34858725
Pulmonary oedema 20.97 10.94 66 98030 47463 34811372
Paranoia 20.95 10.94 78 98018 11990 34846845
Glioma 20.93 10.94 13 98083 356 34858479
Psychomotor disadaptation syndrome 20.81 10.94 8 98088 72 34858763
Cardiac septal hypertrophy 20.76 10.94 12 98084 287 34858548
Urge incontinence 20.66 10.94 15 98081 535 34858300
Squamous cell carcinoma of skin 20.58 10.94 3 98093 10878 34847957
Madarosis 20.53 10.94 11 98085 226 34858609
Drug eruption 20.44 10.94 110 97986 19788 34839047
Asterixis 20.33 10.94 21 98075 1212 34857623
Angina unstable 20.30 10.94 4 98092 11649 34847186
Talipes 20.28 10.94 26 98070 1897 34856938
Completed suicide 20.23 10.94 177 97919 97991 34760844
Blood glucose decreased 20.21 10.94 6 98090 13231 34845604
Cerebellar syndrome 20.19 10.94 29 98067 2359 34856476
Stillbirth 20.15 10.94 10 98086 174 34858661
Tuberous sclerosis complex 20.09 10.94 6 98090 22 34858813
Diverticulitis 20.06 10.94 16 98080 19988 34838847
Necrotising enterocolitis neonatal 20.02 10.94 11 98085 238 34858597
Coma neonatal 19.88 10.94 6 98090 23 34858812
Flushing 19.82 10.94 38 98058 32382 34826453
Iris adhesions 19.82 10.94 11 98085 243 34858592
Rash morbilliform 19.80 10.94 33 98063 3054 34855781
Apallic syndrome 19.58 10.94 11 98085 249 34858586
Autoimmune thyroiditis 19.37 10.94 20 98076 1154 34857681
Herpes simplex encephalitis 19.34 10.94 12 98084 328 34858507
Mental disorder 19.10 10.94 89 98007 15120 34843715
Systemic infection 19.09 10.94 44 98052 5168 34853667
Localised infection 19.02 10.94 13 98083 17574 34841261
Bone pain 18.98 10.94 18 98078 20668 34838167
Nasal congestion 18.98 10.94 22 98074 23035 34835800
Nervous system disorder 18.93 10.94 86 98010 14457 34844378
Hostility 18.81 10.94 17 98079 831 34858004
Intentional product use issue 18.81 10.94 95 98001 59721 34799114
Feeling hot 18.80 10.94 16 98080 19356 34839479
Product use issue 18.79 10.94 265 97831 62951 34795884
Systemic inflammatory response syndrome 18.66 10.94 51 98045 6658 34852177
Alcohol use disorder 18.61 10.94 6 98090 30 34858805
Coronary artery occlusion 18.61 10.94 4 98092 10958 34847877
Craniocerebral injury 18.47 10.94 33 98063 3230 34855605
Rectal haemorrhage 18.39 10.94 55 98041 40194 34818641
Agnosia 18.31 10.94 7 98089 62 34858773
Aplasia 18.22 10.94 40 98056 4548 34854287
Bicuspid aortic valve 18.17 10.94 10 98086 217 34858618
Oropharyngeal pain 18.07 10.94 46 98050 35439 34823396
Amnesia 17.99 10.94 132 97964 26431 34832404
Intestinal intraepithelial lymphocytes increased 17.91 10.94 9 98087 161 34858674
Cellulitis 17.87 10.94 82 98014 52869 34805966
Subdural haematoma 17.76 10.94 108 97988 20313 34838522
Drug withdrawal headache 17.76 10.94 5 98091 14 34858821
Chemotherapeutic drug level above therapeutic 17.76 10.94 5 98091 14 34858821
Lower respiratory tract infection 17.71 10.94 39 98057 31598 34827237
Gastric ulcer 17.69 10.94 11 98085 15639 34843196
Anaplastic astrocytoma 17.68 10.94 8 98088 112 34858723
Agranulocytosis 17.66 10.94 121 97975 23700 34835135
Deja vu 17.50 10.94 5 98091 15 34858820
Mixed liver injury 17.49 10.94 30 98066 2843 34855992
Metastatic malignant melanoma 17.44 10.94 25 98071 2030 34856805
Hypernatraemia 17.44 10.94 58 98038 8432 34850403
Cytotoxic oedema 17.38 10.94 9 98087 172 34858663
Head banging 17.33 10.94 9 98087 173 34858662
Night sweats 17.25 10.94 14 98082 17338 34841497
Renal injury 17.23 10.94 5 98091 11190 34847645
Posture abnormal 17.21 10.94 26 98070 2213 34856622
Herpes zoster 17.20 10.94 45 98051 34354 34824481
Encephalitis viral 17.09 10.94 19 98077 1193 34857642
Potter's syndrome 17.03 10.94 5 98091 17 34858818
Product administered to patient of inappropriate age 17.01 10.94 32 98064 3259 34855576
Bronchopulmonary aspergillosis 17.00 10.94 10 98086 14649 34844186
Prescribed overdose 16.99 10.94 67 98029 10580 34848255
Haematochezia 16.96 10.94 70 98026 46464 34812371
Epistaxis 16.93 10.94 95 98001 58156 34800679
Dyspepsia 16.92 10.94 50 98046 36682 34822153
Gastric haemorrhage 16.90 10.94 4 98092 10257 34848578
Neonatal respiratory depression 16.90 10.94 12 98084 413 34858422
Retinogram abnormal 16.89 10.94 8 98088 125 34858710
Burning sensation 16.88 10.94 16 98080 18378 34840457
Injection site erythema 16.86 10.94 12 98084 15887 34842948
Intentional self-injury 16.86 10.94 80 98016 13691 34845144
Central nervous system lesion 16.86 10.94 48 98048 6415 34852420
Gastritis 16.82 10.94 22 98074 21851 34836984
Infant irritability 16.79 10.94 6 98090 43 34858792
Brain neoplasm malignant 16.78 10.94 16 98080 838 34857997
Arteriosclerosis coronary artery 16.77 10.94 7 98089 12478 34846357
Crying 16.74 10.94 45 98051 5817 34853018
Neurodevelopmental disorder 16.60 10.94 12 98084 425 34858410
Congenital anomaly 16.56 10.94 20 98076 1373 34857462
Caesarean section 16.45 10.94 25 98071 2139 34856696
Cleft palate 16.45 10.94 14 98082 631 34858204
Subacute sclerosing panencephalitis 16.40 10.94 5 98091 20 34858815
Pulmonary valve stenosis congenital 16.40 10.94 8 98088 134 34858701
Lichenoid keratosis 16.34 10.94 27 98069 2481 34856354
Paternal exposure before pregnancy 16.33 10.94 6 98090 47 34858788
Meningeal disorder 16.30 10.94 11 98085 348 34858487
Brain tumour operation 16.29 10.94 4 98092 5 34858830
Paresis 16.26 10.94 25 98071 2161 34856674
Superinfection 16.26 10.94 27 98069 2492 34856343
Physical assault 16.23 10.94 18 98078 1127 34857708
Myocardial ischaemia 16.15 10.94 15 98081 17393 34841442
Osteonecrosis 16.11 10.94 11 98085 14879 34843956
Toxic skin eruption 16.08 10.94 69 98027 11316 34847519
Caudal regression syndrome 16.01 10.94 6 98090 50 34858785
Pneumothorax 15.95 10.94 18 98078 19074 34839761
Dysphemia 15.94 10.94 21 98075 1574 34857261
Retinitis viral 15.93 10.94 7 98089 91 34858744
Musculoskeletal stiffness 15.92 10.94 72 98024 46608 34812227
Bladder hypertrophy 15.90 10.94 14 98082 661 34858174
Urticaria 15.90 10.94 106 97990 62271 34796564
Presyncope 15.89 10.94 18 98078 19041 34839794
Diabetes mellitus inadequate control 15.88 10.94 9 98087 13455 34845380
Type 2 diabetes mellitus 15.86 10.94 13 98083 16019 34842816
CSF white blood cell count increased 15.81 10.94 6 98090 52 34858783
Drug hypersensitivity 15.80 10.94 147 97949 80382 34778453
Apathy 15.73 10.94 49 98047 6883 34851952
Colitis ulcerative 15.60 10.94 14 98082 16506 34842329
Heart rate decreased 15.51 10.94 42 98054 31703 34827132
Barbiturates positive 15.49 10.94 4 98092 7 34858828
Stomatitis 15.46 10.94 64 98032 42450 34816385
Haemorrhoids 15.46 10.94 11 98085 14564 34844271
Psychomotor skills impaired 15.45 10.94 34 98062 3872 34854963
Patent ductus arteriosus 15.37 10.94 31 98065 3323 34855512
Fall 15.32 10.94 706 97390 202179 34656656
Orthostatic hypotension 15.31 10.94 31 98065 25888 34832947
Wrong dose 15.28 10.94 13 98083 586 34858249
Hypothalamo-pituitary disorder 15.27 10.94 15 98081 815 34858020
Conjunctival irritation 15.22 10.94 7 98089 102 34858733
Cryptitis 15.15 10.94 9 98087 227 34858608
Agitation neonatal 15.14 10.94 17 98079 1079 34857756
Hot flush 15.13 10.94 17 98079 18049 34840786
Syncope 15.05 10.94 174 97922 91277 34767558
Dysmetria 15.03 10.94 13 98083 599 34858236
Executive dysfunction 14.94 10.94 9 98087 233 34858602
Perseveration 14.92 10.94 7 98089 107 34858728
Blood pressure systolic increased 14.83 10.94 26 98070 22926 34835909
Prominent epicanthal folds 14.82 10.94 8 98088 167 34858668
Accidental overdose 14.75 10.94 102 97994 20038 34838797
Psychomotor retardation 14.70 10.94 32 98064 3618 34855217
Dry mouth 14.67 10.94 40 98056 30125 34828710
Injection site swelling 14.64 10.94 7 98089 11520 34847315
Pyruvate kinase deficiency anaemia 14.64 10.94 3 98093 0 34858835
Post-traumatic epilepsy 14.64 10.94 3 98093 0 34858835
Brain lobectomy 14.64 10.94 3 98093 0 34858835
Gallbladder agenesis 14.64 10.94 3 98093 0 34858835
Infant sedation 14.64 10.94 3 98093 0 34858835
Renal disorder 14.60 10.94 31 98065 25449 34833386
Acute hepatic failure 14.59 10.94 78 98018 13996 34844839
Duplicate therapy error 14.56 10.94 8 98088 173 34858662
Gross motor delay 14.56 10.94 10 98086 326 34858509
Skin ulcer 14.51 10.94 25 98071 22191 34836644
Anaphylactic shock 14.48 10.94 14 98082 15927 34842908
Impaired healing 14.47 10.94 13 98083 15321 34843514
Use of accessory respiratory muscles 14.47 10.94 11 98085 421 34858414
Frequent bowel movements 14.44 10.94 9 98087 12778 34846057
Tonic clonic movements 14.41 10.94 16 98080 1003 34857832
Unresponsive to stimuli 14.33 10.94 129 97967 27440 34831395
Dysarthria 14.31 10.94 155 97941 34627 34824208
Red blood cell sedimentation rate increased 14.27 10.94 4 98092 9158 34849677
Glycosylated haemoglobin increased 14.27 10.94 7 98089 11353 34847482
Drug dependence 14.27 10.94 29 98067 24188 34834647
Swollen tongue 14.25 10.94 12 98084 14593 34844242
Blood urea increased 14.23 10.94 41 98055 30323 34828512
Product taste abnormal 14.19 10.94 17 98079 1157 34857678
Coma 14.19 10.94 193 97903 45485 34813350
Fatigue 14.18 10.94 874 97222 369779 34489056
COVID-19 pneumonia 14.17 10.94 16 98080 16951 34841884
Movement disorder 14.17 10.94 70 98026 12178 34846657
Astrocytoma 14.16 10.94 8 98088 183 34858652
Lethargy 14.13 10.94 177 97919 40945 34817890
Upper airway obstruction 14.10 10.94 13 98083 652 34858183
Cerebellar atrophy 14.08 10.94 12 98084 542 34858293
Dystonia 14.01 10.94 64 98032 10781 34848054
Monorchidism 14.00 10.94 4 98092 12 34858823
Vitamin B6 decreased 14.00 10.94 4 98092 12 34858823
Ejection fraction decreased 13.98 10.94 20 98076 19134 34839701
Bronchiectasis 13.98 10.94 5 98091 9796 34849039
Renal impairment 13.98 10.94 184 97912 94329 34764506
Oligodendroglioma 13.97 10.94 5 98091 36 34858799
Hypersensitivity 13.96 10.94 107 97989 60928 34797907
Micturition frequency decreased 13.91 10.94 10 98086 351 34858484
Tricuspid valve incompetence 13.89 10.94 5 98091 9755 34849080
Circadian rhythm sleep disorder 13.88 10.94 11 98085 448 34858387
Unevaluable event 13.85 10.94 46 98050 32544 34826291
Microvillous inclusion disease 13.82 10.94 8 98088 192 34858643
Gastrointestinal malformation 13.80 10.94 6 98090 76 34858759
Guillain-Barre syndrome 13.78 10.94 43 98053 6044 34852791
Hallucination 13.78 10.94 212 97884 51286 34807549
Niemann-Pick disease 13.76 10.94 4 98092 13 34858822
Foetal cardiac disorder 13.76 10.94 4 98092 13 34858822
Vagal nerve stimulator implantation 13.76 10.94 4 98092 13 34858822
Gastrointestinal disorder 13.70 10.94 49 98047 33899 34824936
Therapeutic response unexpected 13.68 10.94 59 98037 9698 34849137
Low set ears 13.67 10.94 11 98085 458 34858377
Haemorrhage intracranial 13.66 10.94 84 98012 15862 34842973
Pancreatic carcinoma 13.65 10.94 4 98092 8897 34849938
Creutzfeldt-Jakob disease 13.63 10.94 5 98091 39 34858796
Cholelithiasis 13.62 10.94 24 98072 21124 34837711
Aspartate aminotransferase increased 13.61 10.94 123 97973 67660 34791175
Limb discomfort 13.59 10.94 7 98089 11040 34847795
Probiotic therapy 13.55 10.94 7 98089 133 34858702
Penoscrotal fusion 13.54 10.94 4 98092 14 34858821
Acute kidney injury 13.50 10.94 709 97387 304279 34554556
Swelling 13.48 10.94 67 98029 42299 34816536
Cerebral amyloid angiopathy 13.46 10.94 7 98089 135 34858700
Crystalluria 13.43 10.94 11 98085 470 34858365
Serratia sepsis 13.32 10.94 6 98090 83 34858752
Haematuria 13.31 10.94 84 98012 49982 34808853
Cataract 13.29 10.94 34 98062 26152 34832683
Initial insomnia 13.28 10.94 28 98068 3096 34855739
Post-anoxic myoclonus 13.12 10.94 4 98092 16 34858819
Full blood count decreased 13.09 10.94 19 98077 18069 34840766
Hyperpyrexia 13.05 10.94 26 98070 2762 34856073
Craniofacial deformity 13.01 10.94 6 98090 88 34858747
Oropharyngeal swelling 13.00 10.94 11 98085 492 34858343
Large granular lymphocytosis 12.98 10.94 8 98088 216 34858619
Thrombocytopenia neonatal 12.97 10.94 10 98086 391 34858444
Palpitations 12.86 10.94 63 98033 39923 34818912
Oesophageal carcinoma 12.85 10.94 5 98091 9299 34849536
Therapeutic product effect decreased 12.82 10.94 52 98044 34691 34824144
Renal cancer 12.77 10.94 3 98093 7732 34851103
Hyperacusis 12.76 10.94 14 98082 866 34857969
Congenital megaureter 12.76 10.94 7 98089 151 34858684
Epileptic psychosis 12.75 10.94 4 98092 18 34858817
Head injury 12.73 10.94 91 98005 18069 34840766
Dry skin 12.73 10.94 45 98051 31242 34827593
Lennox-Gastaut syndrome 12.72 10.94 5 98091 48 34858787
Feeling cold 12.71 10.94 7 98089 10632 34848203
Contraindicated product prescribed 12.63 10.94 10 98086 407 34858428
Accidental exposure to product by child 12.59 10.94 18 98078 1458 34857377
CSF glucose increased 12.57 10.94 3 98093 3 34858832
Urinary tract malformation 12.57 10.94 3 98093 3 34858832
Near drowning 12.57 10.94 3 98093 3 34858832
Ganglioglioma 12.57 10.94 3 98093 3 34858832
Incoherent 12.54 10.94 34 98062 4418 34854417
Sinus node dysfunction 12.52 10.94 33 98063 4216 34854619
Drug monitoring procedure not performed 12.47 10.94 9 98087 318 34858517
Contusion 12.45 10.94 56 98040 36308 34822527
Foetal anticonvulsant syndrome 12.44 10.94 16 98080 1171 34857664
Hyporeflexia 12.43 10.94 21 98075 1966 34856869
Blood pressure decreased 12.41 10.94 89 98007 51426 34807409
Pain in jaw 12.38 10.94 11 98085 13029 34845806
Restless legs syndrome 12.37 10.94 4 98092 8350 34850485
Infusion site induration 12.35 10.94 8 98088 236 34858599
Bradykinesia 12.26 10.94 31 98065 3862 34854973
Tremor 12.26 10.94 311 97785 82276 34776559
Device malfunction 12.24 10.94 7 98089 10414 34848421
Apraxia 12.23 10.94 17 98079 1341 34857494
Amnestic disorder 12.14 10.94 8 98088 243 34858592
Blood ketone body increased 12.09 10.94 10 98086 433 34858402
Hydronephrosis 12.08 10.94 7 98089 10339 34848496
Heart rate irregular 12.05 10.94 16 98080 15791 34843044
Diabetic ketoacidosis 12.04 10.94 20 98076 18012 34840823
Cytomegalovirus viraemia 12.04 10.94 3 98093 7427 34851408
Blood uric acid increased 11.98 10.94 6 98090 9618 34849217
Coronary artery stenosis 11.97 10.94 6 98090 9610 34849225
MELAS syndrome 11.97 10.94 5 98091 57 34858778
Ischaemic stroke 11.96 10.94 90 98006 18160 34840675
Acute generalised exanthematous pustulosis 11.93 10.94 44 98052 6732 34852103
Tinnitus 11.93 10.94 24 98072 20094 34838741
Muscle contracture 11.85 10.94 16 98080 1228 34857607
Cardiomyopathy 11.83 10.94 18 98078 16790 34842045
Tooth disorder 11.82 10.94 8 98088 10874 34847961
Athetosis 11.81 10.94 5 98091 59 34858776
Periventricular haemorrhage neonatal 11.80 10.94 4 98092 24 34858811
Emphysema 11.77 10.94 6 98090 9519 34849316
Arrhythmia 11.75 10.94 56 98040 35752 34823083
Hepatic cirrhosis 11.75 10.94 19 98077 17295 34841540
Squamous cell carcinoma 11.73 10.94 9 98087 11466 34847369
Pathogen resistance 11.67 10.94 6 98090 9476 34849359
Myositis 11.67 10.94 10 98086 12060 34846775
Lower gastrointestinal haemorrhage 11.61 10.94 6 98090 9446 34849389
Intestinal ischaemia 11.60 10.94 48 98048 7746 34851089
Cerebral haemorrhage neonatal 11.59 10.94 8 98088 263 34858572
Bronchospasm 11.51 10.94 8 98088 10723 34848112
Metastases to bone 11.48 10.94 10 98086 11960 34846875
Hyperkinesia 11.48 10.94 19 98077 1749 34857086
Arteriosclerosis 11.47 10.94 10 98086 11958 34846877
Onychophagia 11.45 10.94 5 98091 64 34858771
Automatism 11.39 10.94 6 98090 119 34858716
Asthenospermia 11.38 10.94 5 98091 65 34858770
Blood bilirubin increased 11.37 10.94 62 98034 38234 34820601
Transient epileptic amnesia 11.36 10.94 3 98093 6 34858829
Cortical dysplasia 11.36 10.94 3 98093 6 34858829
Assisted delivery 11.36 10.94 3 98093 6 34858829
Verbigeration 11.36 10.94 3 98093 6 34858829
Large intestine polyp 11.35 10.94 4 98092 7910 34850925
Brain cancer metastatic 11.34 10.94 6 98090 120 34858715
Neck pain 11.32 10.94 35 98061 25314 34833521
Metabolic encephalopathy 11.32 10.94 32 98064 4260 34854575
Platelet dysfunction 11.30 10.94 8 98088 274 34858561
CSF white blood cell count decreased 11.28 10.94 4 98092 28 34858807
Proteinuria 11.26 10.94 22 98074 18620 34840215
Haematuria traumatic 11.26 10.94 7 98089 192 34858643
Economic problem 11.24 10.94 16 98080 1291 34857544
Retrognathia 11.22 10.94 8 98088 277 34858558
Congenital hydronephrosis 11.22 10.94 12 98084 721 34858114
Drug level below therapeutic 11.21 10.94 38 98058 5577 34853258
Gastric disorder 11.21 10.94 11 98085 12430 34846405
Injection site reaction 11.20 10.94 12 98084 13021 34845814
Abscess 11.18 10.94 10 98086 11807 34847028
Musculoskeletal chest pain 11.17 10.94 7 98089 9911 34848924
Congenital nose malformation 11.16 10.94 7 98089 195 34858640
School refusal 11.16 10.94 4 98092 29 34858806
Mental disability 11.11 10.94 5 98091 69 34858766
Hypotension 11.01 10.94 509 97587 221140 34637695
Hepatic cytolysis 10.96 10.94 74 98022 14422 34844413
White blood cell count increased 10.96 10.94 69 98027 41082 34817753
Abdominal wall haematoma 10.94 10.94 19 98077 1818 34857017

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 7013.75 10.11 4607 167959 184227 79387595
Status epilepticus 3601.43 10.11 1518 171048 23523 79548299
Generalised tonic-clonic seizure 1944.29 10.11 1201 171365 42709 79529113
Epilepsy 1761.92 10.11 1099 171467 39761 79532061
Multiple-drug resistance 1513.84 10.11 607 171959 8201 79563621
Partial seizures 1179.92 10.11 511 172055 8467 79563355
Aggression 1088.98 10.11 894 171672 50064 79521758
Drug reaction with eosinophilia and systemic symptoms 698.54 10.11 776 171790 63468 79508354
Drug ineffective 695.40 10.11 4343 168223 1076570 78495252
Psychogenic seizure 648.39 10.11 218 172348 1713 79570109
Product substitution issue 550.88 10.11 410 172156 19846 79551976
Somnolence 545.04 10.11 1431 171135 237550 79334272
Petit mal epilepsy 540.85 10.11 259 172307 5468 79566354
Arthralgia 529.24 10.11 290 172276 571513 79000309
Focal dyscognitive seizures 508.02 10.11 214 172352 3298 79568524
Cytokine release syndrome 504.29 10.11 498 172068 35500 79536322
Rhabdomyolysis 466.11 10.11 816 171750 102315 79469507
Irritability 460.98 10.11 505 172061 40639 79531183
Dyspnoea 429.15 10.11 750 171816 856275 78715547
Pain 393.49 10.11 572 171994 703230 78868592
Rheumatoid arthritis 392.58 10.11 13 172553 208457 79363365
Agitation 379.93 10.11 733 171833 98982 79472840
Encephalopathy 374.01 10.11 585 171981 66812 79505010
Joint swelling 368.95 10.11 86 172480 288560 79283262
Paradoxical drug reaction 352.32 10.11 210 172356 6975 79564847
Drug interaction 348.09 10.11 1795 170771 413388 79158434
Abnormal behaviour 335.39 10.11 404 172162 36017 79535805
Thrombocytopenia 334.97 10.11 1296 171270 263963 79307859
Anticonvulsant drug level decreased 324.35 10.11 131 172435 1803 79570019
Drug resistance 323.15 10.11 427 172139 41786 79530036
Myoclonic epilepsy 315.18 10.11 129 172437 1841 79569981
Arthropathy 313.69 10.11 17 172549 177094 79394728
Ataxia 313.41 10.11 326 172240 24713 79547109
Myoclonus 310.67 10.11 340 172226 27320 79544502
Behaviour disorder 305.62 10.11 183 172383 6130 79565692
Hyperammonaemia 302.64 10.11 225 172341 10868 79560954
Synovitis 300.60 10.11 5 172561 150729 79421093
Aphasia 293.82 10.11 430 172136 46302 79525520
Drug withdrawal convulsions 293.74 10.11 127 172439 2093 79569729
Abdominal discomfort 282.62 10.11 95 172471 250632 79321190
Immune effector cell-associated neurotoxicity syndrome 268.86 10.11 164 172402 5684 79566138
Psychotic disorder 266.16 10.11 385 172181 41017 79530805
Drug ineffective for unapproved indication 262.62 10.11 429 172137 50809 79521013
Sudden unexplained death in epilepsy 258.70 10.11 84 172482 584 79571238
Anticonvulsant drug level increased 256.66 10.11 122 172444 2531 79569291
Cognitive disorder 249.28 10.11 500 172066 69426 79502396
Pregnancy 244.19 10.11 296 172270 26555 79545267
Infusion related reaction 242.97 10.11 97 172469 230140 79341682
Contraindicated product administered 231.13 10.11 33 172533 157505 79414317
Hyperammonaemic encephalopathy 227.29 10.11 137 172429 4645 79567177
No adverse event 226.27 10.11 337 172229 36855 79534967
Sinusitis 218.66 10.11 75 172491 195426 79376396
Diarrhoea 210.81 10.11 1086 171480 879403 78692419
Nausea 208.21 10.11 1219 171347 955977 78615845
Pain in extremity 206.38 10.11 293 172273 364245 79207577
Partial seizures with secondary generalisation 205.89 10.11 70 172496 571 79571251
Seizure cluster 199.14 10.11 61 172505 341 79571481
Electroencephalogram abnormal 199 10.11 132 172434 5302 79566520
Aura 197.45 10.11 75 172491 867 79570955
Swelling 196.94 10.11 112 172454 216599 79355223
Peripheral swelling 191.07 10.11 181 172385 269436 79302386
Hepatocellular injury 188.72 10.11 356 172210 47237 79524585
Pemphigus 188.14 10.11 6 172560 99576 79472246
Exposure during pregnancy 185.34 10.11 560 172006 100572 79471250
Stevens-Johnson syndrome 184.76 10.11 316 172250 38850 79532972
Tonic convulsion 181.49 10.11 91 172475 2129 79569693
Foetal exposure during pregnancy 179.71 10.11 127 172439 5663 79566159
Change in seizure presentation 179.49 10.11 60 172506 462 79571360
Anticonvulsant drug level above therapeutic 178.24 10.11 74 172492 1097 79570725
Malaise 175.60 10.11 513 172053 489356 79082466
Neurotoxicity 170.32 10.11 275 172291 32243 79539579
Infantile spasms 169.87 10.11 50 172516 238 79571584
Confusional state 166.98 10.11 1219 171347 316778 79255044
Abortion spontaneous 166.23 10.11 258 172308 29249 79542573
Nasopharyngitis 163.42 10.11 185 172381 253696 79318126
Pericarditis 162.18 10.11 18 172548 104218 79467604
Glossodynia 160.39 10.11 18 172548 103319 79468503
Myocardial infarction 159.09 10.11 101 172465 184028 79387794
Brain oedema 156.66 10.11 231 172335 25032 79546790
Overdose 150.82 10.11 792 171774 183414 79388408
Discomfort 149.69 10.11 43 172523 125574 79446248
Hemiparesis 148.48 10.11 264 172302 33469 79538353
Back pain 145.41 10.11 273 172293 303907 79267915
Therapeutic product effect decreased 142.77 10.11 89 172477 163774 79408048
Glioblastoma 141.49 10.11 70 172496 1590 79570232
Hypersensitivity 141.27 10.11 218 172348 262021 79309801
Anger 139.72 10.11 179 172387 16983 79554839
Postictal psychosis 137.94 10.11 38 172528 135 79571687
Alopecia 137.85 10.11 179 172387 231176 79340646
Hallucination, visual 137.49 10.11 251 172315 32478 79539344
Arthritis 137.49 10.11 39 172527 114841 79456981
Off label use 137.09 10.11 2736 169830 904479 78667343
Helicobacter infection 136.15 10.11 3 172563 69701 79502121
Pneumonia aspiration 134.31 10.11 383 172183 66584 79505238
Encephalitis autoimmune 130.91 10.11 74 172492 2220 79569602
Psoriatic arthropathy 130.60 10.11 10 172556 77989 79493833
Duodenal ulcer perforation 128.74 10.11 3 172563 66208 79505614
Asthma 128.27 10.11 66 172500 135029 79436793
Delirium 128.14 10.11 439 172127 84188 79487634
Eosinophilia 127.95 10.11 295 172271 45050 79526772
Cholestasis 127.70 10.11 321 172245 51788 79520034
Toxic epidermal necrolysis 126.87 10.11 291 172275 44290 79527532
Substance-induced psychotic disorder 125.74 10.11 83 172483 3306 79568516
Drug hypersensitivity 125.38 10.11 289 172277 298627 79273195
Acute generalised exanthematous pustulosis 125.08 10.11 170 172396 17084 79554738
Impaired healing 124.78 10.11 20 172546 87635 79484187
Cardiac failure congestive 124.53 10.11 77 172489 142325 79429497
Anticonvulsant drug level below therapeutic 124.18 10.11 56 172510 1025 79570797
Nystagmus 124.01 10.11 129 172437 9775 79562047
Mood altered 123.59 10.11 172 172394 17675 79554147
Injection site pain 122.43 10.11 64 172502 129774 79442048
Cough 122.14 10.11 397 172169 366392 79205430
Disorientation 122.00 10.11 355 172211 62421 79509401
Disturbance in attention 121.43 10.11 310 172256 50491 79521331
Lower respiratory tract infection 121.39 10.11 64 172502 129156 79442666
Leukopenia 120.61 10.11 536 172030 115977 79455845
Glioblastoma multiforme 120.41 10.11 57 172509 1171 79570651
Propofol infusion syndrome 118.69 10.11 66 172500 1917 79569905
Aplastic anaemia 117.24 10.11 168 172398 17737 79554085
Musculoskeletal stiffness 115.34 10.11 125 172441 174883 79396939
Chest pain 115.14 10.11 277 172289 282027 79289795
Psychomotor hyperactivity 114.62 10.11 161 172405 16688 79555134
Low birth weight baby 114.21 10.11 45 172521 578 79571244
Posterior reversible encephalopathy syndrome 113.51 10.11 204 172362 26077 79545745
Irritable bowel syndrome 110.07 10.11 6 172560 62235 79509587
Pruritus 109.85 10.11 460 172106 394188 79177634
Suicidal ideation 109.50 10.11 389 172177 75951 79495871
Mental status changes 109.04 10.11 356 172210 66603 79505219
Simple partial seizures 108.89 10.11 45 172521 659 79571163
Osteoarthritis 107.55 10.11 28 172538 87281 79484541
Systemic lupus erythematosus 106.63 10.11 65 172501 121084 79450738
Drug intolerance 105.47 10.11 262 172304 263857 79307965
Altered state of consciousness 104.30 10.11 267 172299 43555 79528267
Brain neoplasm 103.96 10.11 91 172475 5555 79566267
Drug level decreased 103.03 10.11 141 172425 14261 79557561
Rash maculo-papular 102.20 10.11 310 172256 55768 79516054
Delusion 101.92 10.11 169 172397 20254 79551568
Depressed level of consciousness 101.81 10.11 447 172119 96205 79475617
Hallucination, auditory 101.61 10.11 170 172396 20523 79551299
Atonic seizures 101.33 10.11 44 172522 733 79571089
Drug level increased 101.10 10.11 248 172318 39403 79532419
Haemophagocytic lymphohistiocytosis 98.81 10.11 173 172393 21664 79550158
Chest discomfort 98.50 10.11 92 172474 137952 79433870
Abdominal pain upper 98.23 10.11 211 172355 223608 79348214
Fibromyalgia 97.86 10.11 12 172554 64328 79507494
Product administration error 96.33 10.11 213 172353 31633 79540189
Abdominal pain 95.35 10.11 476 172090 389093 79182729
Blood pressure increased 94.64 10.11 197 172369 211163 79360659
Pancytopenia 92.43 10.11 645 171921 165100 79406722
Oedema peripheral 91.83 10.11 262 172304 252026 79319796
Cerebral haemorrhage 91.54 10.11 304 172262 57369 79514453
Muscle injury 88.04 10.11 4 172562 48557 79523265
Exposure via breast milk 87.87 10.11 43 172523 953 79570869
Psoriasis 87.69 10.11 42 172524 89545 79482277
Hypertension 87.07 10.11 394 172172 330598 79241224
Persecutory delusion 86.16 10.11 77 172489 4832 79566990
Personality change 85.83 10.11 108 172458 10062 79561760
Injection site erythema 85.66 10.11 31 172535 78166 79493656
Hyponatraemia 85.43 10.11 668 171898 177180 79394642
Premature delivery 85.02 10.11 169 172397 23298 79548524
Agranulocytosis 84.00 10.11 251 172315 44779 79527043
Cerebellar ataxia 83.54 10.11 52 172514 1869 79569953
Blood creatine phosphokinase increased 81.63 10.11 321 172245 65769 79506053
Bronchitis 80.98 10.11 98 172468 130546 79441276
Acute psychosis 80.25 10.11 69 172497 4111 79567711
Intellectual disability 79.18 10.11 44 172522 1276 79570546
Toxic encephalopathy 78.83 10.11 110 172456 11330 79560492
Affective disorder 77.73 10.11 93 172473 8226 79563596
COVID-19 77.50 10.11 139 172427 157535 79414287
Coronary artery disease 76.91 10.11 23 172543 65451 79506371
Thinking abnormal 76.82 10.11 117 172449 13044 79558778
Excessive eye blinking 76.39 10.11 47 172519 1654 79570168
Neurological decompensation 76.00 10.11 74 172492 5179 79566643
Necrosis ischaemic 75.59 10.11 40 172526 1050 79570772
Maternal exposure before pregnancy 75.58 10.11 68 172498 4305 79567517
Paranoia 75.34 10.11 144 172422 19288 79552534
Hallucination 75.21 10.11 376 172190 85369 79486453
Febrile convulsion 75.05 10.11 38 172528 908 79570914
Intentional self-injury 74.55 10.11 195 172371 32224 79539598
Red blood cell sedimentation rate increased 73.87 10.11 7 172559 45935 79525887
Fatigue 73.44 10.11 1496 171070 928231 78643591
Nasal congestion 73.24 10.11 37 172529 76515 79495307
Speech disorder 72.62 10.11 271 172295 54174 79517648
Small for dates baby 72.18 10.11 30 172536 446 79571376
Treatment noncompliance 72.10 10.11 263 172303 52005 79519817
Wheezing 71.79 10.11 88 172478 116576 79455246
Affect lability 71.32 10.11 104 172462 11155 79560667
Gaze palsy 71.09 10.11 56 172510 2949 79568873
Central nervous system lesion 69.92 10.11 113 172453 13255 79558567
Caesarean section 69.75 10.11 109 172457 12426 79559396
Stupor 69.49 10.11 80 172486 6792 79565030
Coma 69.17 10.11 413 172153 100236 79471586
Wound 69.03 10.11 90 172476 116089 79455733
Suicide attempt 68.78 10.11 358 172208 82574 79489248
Respiratory disorder neonatal 68.67 10.11 18 172548 50 79571772
Developmental delay 68.34 10.11 39 172527 1192 79570630
Encephalitis 68.17 10.11 118 172448 14642 79557180
Mitochondrial DNA mutation 68.06 10.11 28 172538 405 79571417
Myalgia 67.37 10.11 193 172373 185448 79386374
Suicidal behaviour 67.27 10.11 56 172510 3191 79568631
Memory impairment 67.14 10.11 443 172123 111291 79460531
Toxicity to various agents 66.88 10.11 1282 171284 420258 79151564
Hypothermia 66.40 10.11 150 172416 22596 79549226
Hypotonia 66.24 10.11 108 172458 12762 79559060
Knee arthroplasty 65.93 10.11 8 172558 43240 79528582
Intracranial tumour haemorrhage 65.56 10.11 29 172537 506 79571316
Idiopathic generalised epilepsy 65.18 10.11 17 172549 46 79571776
Gastrooesophageal reflux disease 64.82 10.11 78 172488 104168 79467654
Gastrointestinal disorder 64.41 10.11 103 172463 122102 79449720
Obsessive-compulsive disorder 63.33 10.11 71 172495 5856 79565966
Infection 62.77 10.11 289 172277 241423 79330399
Pleocytosis 62.70 10.11 39 172527 1400 79570422
Bradyphrenia 62.68 10.11 95 172471 10545 79561277
Night sweats 61.74 10.11 18 172548 52077 79519745
Irregular sleep phase 61.62 10.11 18 172548 83 79571739
Hip arthroplasty 61.54 10.11 4 172562 35752 79536070
Pulmonary fibrosis 60.71 10.11 11 172555 44101 79527721
Stomatitis 60.57 10.11 143 172423 146614 79425208
Flushing 60.43 10.11 61 172505 88207 79483615
Tubulointerstitial nephritis 60.19 10.11 201 172365 38034 79533788
Muscle twitching 60.08 10.11 152 172414 24612 79547210
Intentional product use issue 59.81 10.11 152 172414 151960 79419862
Injection site pruritus 59.38 10.11 10 172556 42273 79529549
Fluid retention 59.29 10.11 39 172527 69770 79502052
Acute myocardial infarction 58.99 10.11 48 172518 76988 79494834
Folliculitis 58.90 10.11 23 172543 55357 79516465
Acidosis hyperchloraemic 58.68 10.11 31 172535 811 79571011
Lymphopenia 58.58 10.11 172 172394 30385 79541437
Ammonia increased 58.04 10.11 77 172489 7558 79564264
Breast feeding 57.66 10.11 29 172537 683 79571139
Intra-abdominal pressure increased 57.63 10.11 22 172544 258 79571564
Hydrocephalus 57.52 10.11 83 172483 8817 79563005
Temporal lobe epilepsy 57.33 10.11 25 172541 421 79571401
Coma blister 57.13 10.11 21 172545 220 79571602
Epileptic aura 57.00 10.11 16 172550 62 79571760
Feeling hot 56.95 10.11 29 172537 59705 79512117
Maternal exposure during pregnancy 56.52 10.11 496 172070 136042 79435780
Toxic skin eruption 56.36 10.11 139 172427 22154 79549668
Inflammation 56.34 10.11 72 172494 93681 79478141
Dysarthria 56.13 10.11 292 172274 67330 79504492
Blood cholesterol increased 56.02 10.11 59 172507 83661 79488161
Neuropsychiatric symptoms 55.79 10.11 36 172530 1379 79570443
Psychiatric symptom 55.11 10.11 72 172494 6963 79564859
Limbic encephalitis 54.78 10.11 30 172536 845 79570977
Muscle spasms 54.75 10.11 194 172372 174536 79397286
Sopor 54.17 10.11 176 172390 32834 79538988
Depressed mood 53.94 10.11 228 172338 48252 79523570
Urticaria 53.87 10.11 212 172354 184989 79386833
Blood pressure fluctuation 53.74 10.11 40 172526 67105 79504717
Blood pressure systolic increased 53.49 10.11 40 172526 66946 79504876
Herpes zoster 53.38 10.11 74 172492 93009 79478813
Inappropriate antidiuretic hormone secretion 53.23 10.11 151 172415 26162 79545660
Mental disorder 52.37 10.11 168 172398 31134 79540688
Eye movement disorder 52.20 10.11 75 172491 7936 79563886
Productive cough 51.88 10.11 69 172497 88262 79483560
Diabetes insipidus 51.34 10.11 60 172506 5177 79566645
Dyspnoea exertional 51.16 10.11 68 172498 87005 79484817
Injection site swelling 51.08 10.11 19 172547 47113 79524709
Intensive care unit acquired weakness 50.04 10.11 38 172528 1895 79569927
Acute hepatic failure 49.81 10.11 161 172405 29952 79541870
Staring 49.44 10.11 43 172523 2602 79569220
Bursitis 49.20 10.11 9 172557 35835 79535987
Organic brain syndrome 49.10 10.11 23 172543 461 79571361
Injection site reaction 48.74 10.11 29 172537 54756 79517066
Cataract 48.44 10.11 38 172528 62082 79509740
Hypertransaminasaemia 48.25 10.11 90 172476 11834 79559988
Mood swings 48.21 10.11 122 172444 19758 79552064
Contusion 48.08 10.11 163 172403 148613 79423209
Dyskinesia 47.83 10.11 208 172358 44565 79527257
Eastern Cooperative Oncology Group performance status worsened 47.81 10.11 38 172528 2027 79569795
Influenza 47.55 10.11 134 172432 129472 79442350
Autism spectrum disorder 47.13 10.11 30 172536 1122 79570700
Musculoskeletal pain 46.97 10.11 94 172472 102260 79469562
Meningitis aseptic 46.82 10.11 66 172500 6862 79564960
Apathy 46.46 10.11 93 172473 12884 79558938
Dyspepsia 46.38 10.11 104 172462 108583 79463239
Osteonecrosis of jaw 45.89 10.11 18 172548 43208 79528614
Subdural haematoma 45.76 10.11 161 172405 31273 79540549
Hepatic enzyme increased 45.24 10.11 222 172344 182388 79389434
Accidental death 45.16 10.11 51 172515 4240 79567582
Joint stiffness 45.03 10.11 16 172550 40814 79531008
Brain operation 44.98 10.11 24 172542 641 79571181
Mobility decreased 44.32 10.11 127 172439 122048 79449774
Sciatica 44.20 10.11 9 172557 33213 79538609
Abortion induced 44.06 10.11 65 172501 7044 79564778
Osteoporosis 43.61 10.11 32 172534 54080 79517742
Balance disorder 43.47 10.11 364 172202 98493 79473329
Mutism 43.21 10.11 38 172528 2334 79569488
Dry mouth 42.87 10.11 78 172488 87941 79483881
Retinogram abnormal 42.83 10.11 19 172547 334 79571488
Hypoaesthesia 42.74 10.11 221 172345 179131 79392691
CSF oligoclonal band present 42.69 10.11 20 172546 401 79571421
Angina pectoris 42.46 10.11 30 172536 51702 79520120
Oropharyngeal pain 42.42 10.11 110 172456 109243 79462579
Skin ulcer 42.38 10.11 33 172533 54117 79517705
Learning disorder 42.30 10.11 22 172544 557 79571265
Deja vu 42.25 10.11 12 172554 49 79571773
Impulsive behaviour 42.23 10.11 41 172525 2859 79568963
Chronic obstructive pulmonary disease 42.23 10.11 75 172491 85344 79486478
Convulsive threshold lowered 42.11 10.11 26 172540 921 79570901
Autonomic nervous system imbalance 42.02 10.11 51 172515 4579 79567243
Tremor 41.53 10.11 556 172010 169527 79402295
Glomerulonephritis minimal lesion 41.20 10.11 24 172542 763 79571059
Respiratory acidosis 40.98 10.11 81 172485 11119 79560703
Diplopia 40.87 10.11 162 172404 33304 79538518
Developmental regression 40.86 10.11 11 172555 35 79571787
Bradycardia 40.82 10.11 461 172105 135096 79436726
Intentional overdose 40.82 10.11 379 172187 105581 79466241
Metabolic encephalopathy 40.78 10.11 72 172494 9075 79562747
Hypomagnesaemia 40.62 10.11 205 172361 46706 79525116
Condition aggravated 40.52 10.11 1393 171173 499731 79072091
Feeling abnormal 40.33 10.11 192 172374 159007 79412815
Depressive symptom 40.20 10.11 59 172507 6364 79565458
Granuloma annulare 40.10 10.11 22 172544 622 79571200
Clonic convulsion 39.90 10.11 28 172538 1234 79570588
Maternal exposure during breast feeding 39.86 10.11 39 172527 2746 79569076
Coordination abnormal 39.66 10.11 104 172462 17208 79554614
Drug eruption 39.46 10.11 194 172372 43741 79528081
Accidental poisoning 39.46 10.11 31 172535 1626 79570196
Palpitations 39.37 10.11 141 172425 126469 79445353
Constipation 38.86 10.11 408 172158 282642 79289180
Joint range of motion decreased 38.53 10.11 12 172554 33270 79538552
Pneumatosis 38.50 10.11 24 172542 865 79570957
Postictal paralysis 38.37 10.11 18 172548 362 79571460
Rhinorrhoea 38.33 10.11 66 172500 76008 79495814
Ill-defined disorder 38.14 10.11 52 172514 65823 79505999
Atrial fibrillation 38.08 10.11 261 172305 197625 79374197
MELAS syndrome 38.05 10.11 15 172551 193 79571629
Anaemia 38.03 10.11 706 171860 444309 79127513
Postictal state 37.94 10.11 32 172534 1857 79569965
Burning sensation 37.37 10.11 43 172523 58589 79513233
Systemic inflammatory response syndrome 37.32 10.11 79 172487 11386 79560436
Chills 36.75 10.11 200 172366 160034 79411788
Foetal growth restriction 36.72 10.11 33 172533 2086 79569736
Restlessness 36.69 10.11 198 172368 46294 79525528
Gliosis 36.60 10.11 19 172547 479 79571343
Stillbirth 36.60 10.11 44 172522 3911 79567911
Haemorrhage intracranial 36.29 10.11 132 172434 26061 79545761
JC polyomavirus test 36.20 10.11 10 172556 36 79571786
Oedema 35.98 10.11 135 172431 119445 79452377
Diverticulitis 35.94 10.11 28 172538 45908 79525914
Stress 35.77 10.11 74 172492 79538 79492284
Electrocardiogram QRS complex prolonged 35.67 10.11 75 172491 10758 79561064
Haemoglobin decreased 35.67 10.11 308 172258 221811 79350011
Congenital cyst 35.58 10.11 8 172558 8 79571814
Hyperhidrosis 35.35 10.11 188 172378 151304 79420518
Hot flush 35.24 10.11 40 172526 54837 79516985
Unresponsive to stimuli 35.22 10.11 224 172342 55564 79516258
Gastrointestinal haemorrhage 35.20 10.11 182 172384 147537 79424285
Metastases to central nervous system 35.12 10.11 96 172470 16279 79555543
Premature baby 34.90 10.11 42 172524 3738 79568084
Intestinal ischaemia 34.89 10.11 84 172482 13186 79558636
Brief psychotic disorder, with postpartum onset 34.88 10.11 9 172557 23 79571799
Weight increased 34.84 10.11 408 172158 276978 79294844
Injection site bruising 34.69 10.11 23 172543 40979 79530843
Lethargy 34.51 10.11 297 172269 80995 79490827
Major depression 34.14 10.11 66 172500 8914 79562908
Cardiac disorder 34.10 10.11 56 172510 65701 79506121
Transaminases increased 34.06 10.11 210 172356 51533 79520289
Asthenia 34.06 10.11 845 171721 510844 79060978
Cerebral atrophy 34.00 10.11 62 172504 8013 79563809
Plasmapheresis 33.96 10.11 20 172546 649 79571173
Educational problem 33.93 10.11 17 172549 397 79571425
Cross sensitivity reaction 33.87 10.11 41 172525 3671 79568151
Epileptic encephalopathy 33.83 10.11 18 172548 478 79571344
Brain malformation 33.74 10.11 10 172556 49 79571773
Haemoptysis 33.65 10.11 43 172523 55956 79515866
Cellulitis 33.54 10.11 122 172444 108938 79462884
Pleural effusion 33.49 10.11 181 172385 145081 79426741
Prostate cancer 33.47 10.11 15 172551 33253 79538569
Eye pruritus 33.43 10.11 3 172563 20567 79551255
Asterixis 33.43 10.11 35 172531 2672 79569150
Psychomotor retardation 33.33 10.11 53 172513 6131 79565691
Pulmonary arterial hypertension 33.25 10.11 10 172556 28356 79543466
Hyperkalaemia 33.22 10.11 131 172435 114267 79457555
Retrograde amnesia 33.14 10.11 19 172547 586 79571236
Multiple organ dysfunction syndrome 33.12 10.11 402 172164 119844 79451978
Angiofibroma 32.79 10.11 12 172554 124 79571698
Oculogyric crisis 32.64 10.11 36 172530 2916 79568906
Fall 32.32 10.11 1326 171240 486303 79085519
Hypernatraemia 32.28 10.11 86 172480 14365 79557457
Nicotinic acid deficiency 32.18 10.11 13 172553 179 79571643
Loss of personal independence in daily activities 32.05 10.11 114 172452 102466 79469356
Language disorder 31.80 10.11 37 172529 3177 79568645
Failure to suspend medication 31.76 10.11 17 172549 457 79571365
Terminal insomnia 31.67 10.11 24 172542 1193 79570629
Amnesia 31.44 10.11 239 172327 62818 79509004
Bladder cancer 31.32 10.11 3 172563 19523 79552299
Tooth disorder 31.20 10.11 9 172557 26224 79545598
Nervous system disorder 31.20 10.11 128 172438 26728 79545094
Psychomotor skills impaired 31.19 10.11 47 172519 5190 79566632
Non-24-hour sleep-wake disorder 31.08 10.11 9 172557 40 79571782
Cardiac failure 30.90 10.11 202 172364 154640 79417182
Dry eye 30.86 10.11 21 172545 36910 79534912
Congenital megaureter 30.83 10.11 6 172560 0 79571822
Creutzfeldt-Jakob disease 30.76 10.11 13 172553 202 79571620
Upper respiratory tract infection 30.75 10.11 98 172468 91070 79480752
Therapeutic response unexpected 30.63 10.11 104 172462 19842 79551980
Mania 30.54 10.11 98 172468 18162 79553660
Wrong product administered 30.38 10.11 63 172503 8949 79562873
Drop attacks 30.13 10.11 22 172544 1033 79570789
Blood glucose increased 30.10 10.11 137 172429 114838 79456984
Anaplastic astrocytoma 30.05 10.11 12 172554 160 79571662
Apraxia 30.05 10.11 34 172532 2833 79568989
Glioma 30.03 10.11 18 172548 604 79571218
Crystal nephropathy 29.95 10.11 25 172541 1430 79570392
Hypoventilation 29.83 10.11 55 172511 7169 79564653
Cardiac arrest neonatal 29.82 10.11 8 172558 25 79571797
Heart rate increased 29.75 10.11 147 172419 120577 79451245
Rash morbilliform 29.49 10.11 50 172516 6100 79565722
Attention deficit hyperactivity disorder 29.30 10.11 36 172530 3273 79568549
Febrile neutropenia 29.30 10.11 339 172227 230660 79341162
Malignant catatonia 29.27 10.11 16 172550 449 79571373
Weight decreased 29.24 10.11 567 171999 354631 79217191
Gingival hypertrophy 29.15 10.11 35 172531 3107 79568715
Neck pain 29.14 10.11 76 172490 75341 79496481
Meningioma 29.13 10.11 41 172525 4257 79567565
CSF protein increased 29.10 10.11 23 172543 1217 79570605
Plasma cell myeloma 28.90 10.11 44 172522 53215 79518607
Hostility 28.76 10.11 30 172536 2280 79569542
Metabolic acidosis 28.73 10.11 289 172277 82240 79489582
Neuropathy peripheral 28.37 10.11 184 172382 141121 79430701
Throat irritation 28.36 10.11 28 172538 40918 79530904
Malabsorption 28.34 10.11 44 172522 4988 79566834
Osteonecrosis 28.31 10.11 16 172550 31079 79540743
Localised infection 28.04 10.11 24 172542 37551 79534271
Purple glove syndrome 27.82 10.11 13 172553 259 79571563
Acute coronary syndrome 27.55 10.11 6 172560 21127 79550695
Headache 27.53 10.11 1146 171420 652626 78919196
Ischaemic stroke 27.44 10.11 143 172423 32988 79538834
Hepatic cytolysis 27.38 10.11 124 172442 27027 79544795
Head injury 27.38 10.11 156 172410 37213 79534609
Altered pitch perception 27.38 10.11 7 172559 17 79571805
Brain herniation 27.34 10.11 54 172512 7409 79564413
Cerebral haemorrhage neonatal 27.20 10.11 6 172560 5 79571817
Radiation necrosis 27.15 10.11 15 172551 430 79571392
Lennox-Gastaut syndrome 27.10 10.11 12 172554 210 79571612
Device expulsion 27.07 10.11 11 172555 25850 79545972
Heart rate irregular 26.75 10.11 19 172547 32660 79539162
Blood creatinine increased 26.71 10.11 211 172355 154846 79416976
Gastric disorder 26.62 10.11 25 172541 37408 79534414
Diabetes mellitus 26.62 10.11 84 172482 78306 79493516
Opsoclonus myoclonus 26.59 10.11 12 172554 220 79571602
Mucosal ulceration 26.38 10.11 26 172540 1847 79569975
Renal fusion anomaly 26.20 10.11 6 172560 7 79571815
Brain abscess 26.19 10.11 42 172524 4894 79566928
Cerebellar atrophy 26.10 10.11 21 172545 1140 79570682
Diabetes mellitus inadequate control 25.93 10.11 10 172556 24254 79547568
Rash scarlatiniform 25.87 10.11 12 172554 235 79571587
Blood gases abnormal 25.80 10.11 21 172545 1159 79570663
Macroglossia 25.79 10.11 21 172545 1160 79570662
Ear pain 25.76 10.11 20 172546 32849 79538973
Bone pain 25.74 10.11 51 172515 55691 79516131
Hepatitis 25.46 10.11 207 172359 55520 79516302
Tongue biting 25.44 10.11 27 172539 2094 79569728
Product packaging confusion 25.42 10.11 12 172554 245 79571577
Melaena 25.38 10.11 59 172507 60831 79510991
Neutropenia 25.31 10.11 808 171758 286902 79284920
Neurosurgery 25.13 10.11 9 172557 87 79571735
Musculoskeletal discomfort 25.12 10.11 6 172560 19829 79551993
Grip strength decreased 25.11 10.11 8 172558 21861 79549961
Ulcer 25.10 10.11 17 172549 29955 79541867
Ultrasound ovary abnormal 25.04 10.11 9 172557 88 79571734
Angiomyolipoma 24.92 10.11 11 172555 191 79571631
C-reactive protein increased 24.90 10.11 170 172396 128857 79442965
Sputum discoloured 24.88 10.11 8 172558 21735 79550087
Heart rate decreased 24.84 10.11 74 172492 70242 79501580
Blood lactic acid increased 24.68 10.11 72 172494 12672 79559150
Throat tightness 24.51 10.11 15 172551 27892 79543930
CSF measles antibody positive 24.47 10.11 8 172558 57 79571765
Necrobiosis lipoidica diabeticorum 24.19 10.11 7 172559 31 79571791
Neonatal pneumonia 24.19 10.11 7 172559 31 79571791
Abulia 24.11 10.11 19 172547 1001 79570821
Neonatal hypotension 24.01 10.11 7 172559 32 79571790
Rubella antibody positive 24.00 10.11 8 172558 61 79571761
Pulmonary hypertension 23.96 10.11 42 172524 48038 79523784
Eosinophilic cystitis 23.93 10.11 9 172557 101 79571721
Crying 23.81 10.11 106 172460 22937 79548885
Pulmonary oedema 23.79 10.11 104 172462 88150 79483672
Cerebral venous sinus thrombosis 23.72 10.11 27 172539 2264 79569558
Nodule 23.72 10.11 10 172556 22984 79548838
Gastric ulcer 23.70 10.11 23 172543 33882 79537940
Cortical dysplasia 23.63 10.11 6 172560 14 79571808
Cell death 23.60 10.11 39 172527 4660 79567162
Breast cancer 23.51 10.11 23 172543 33758 79538064
Apnoea 23.51 10.11 67 172499 11637 79560185
Anaphylactic shock 23.37 10.11 26 172540 35970 79535852
Rhesus incompatibility 23.34 10.11 6 172560 15 79571807
Slow response to stimuli 23.26 10.11 24 172542 1801 79570021
Atrioventricular block complete 23.26 10.11 84 172482 16526 79555296
Lymphangioleiomyomatosis 23.23 10.11 10 172556 163 79571659
Accidental overdose 23.20 10.11 156 172410 39425 79532397
Brain tumour operation 22.94 10.11 8 172558 71 79571751
Blood pressure diastolic decreased 22.91 10.11 19 172547 30197 79541625
Product name confusion 22.79 10.11 10 172556 171 79571651
Axillary lymphadenectomy 22.76 10.11 5 172561 4 79571818
Staphylococcal scalded skin syndrome 22.70 10.11 13 172553 400 79571422
Drug level below therapeutic 22.70 10.11 59 172507 9711 79562111
Carpal tunnel syndrome 22.68 10.11 7 172559 19521 79552301
Bronchiectasis 22.67 10.11 10 172556 22376 79549446
Colitis ulcerative 22.66 10.11 25 172541 34717 79537105
Depression 22.64 10.11 622 171944 216168 79355654
Bradykinesia 22.32 10.11 52 172514 7991 79563831
Gamma-glutamyltransferase increased 22.28 10.11 198 172368 54482 79517340
Ascites 22.27 10.11 86 172480 75476 79496346
Bladder sphincter atony 22.27 10.11 9 172557 124 79571698
Pulmonary valve stenosis congenital 22.24 10.11 5 172561 5 79571817
Rash 22.22 10.11 1024 171542 577334 78994488
Presyncope 22.19 10.11 34 172532 41020 79530802
Mixed liver injury 22.14 10.11 50 172516 7528 79564294
Diverticulum 22.11 10.11 3 172563 14893 79556929
Illness 21.95 10.11 42 172524 46469 79525353
Platelet dysfunction 21.88 10.11 13 172553 429 79571393
Catastrophic reaction 21.85 10.11 6 172560 21 79571801
Hyperthermia 21.77 10.11 87 172479 17950 79553872
Oropharyngeal oedema 21.77 10.11 13 172553 433 79571389
Paraplegia 21.53 10.11 39 172527 5014 79566808
Neurodevelopmental disorder 21.52 10.11 7 172559 49 79571773
Echopraxia 21.52 10.11 7 172559 49 79571773
Pneumonia 21.52 10.11 1189 171377 659057 78912765
Wrong patient received product 21.43 10.11 37 172529 4581 79567241
Eye pain 21.41 10.11 30 172536 37548 79534274
Arteriosclerosis coronary artery 21.40 10.11 6 172560 17810 79554012
Hepatic function abnormal 21.27 10.11 247 172319 72860 79498962
Cardiopulmonary failure 21.14 10.11 46 172520 6755 79565067
Craniotomy 21.14 10.11 13 172553 457 79571365
Dystonia 21.04 10.11 97 172469 21302 79550520
Dysmorphism 21.00 10.11 14 172552 567 79571255
Type 2 diabetes mellitus 20.99 10.11 59 172507 57063 79514759
Thrombosis 20.95 10.11 102 172464 83998 79487824
Congenital renal disorder 20.93 10.11 5 172561 8 79571814
Automatism epileptic 20.93 10.11 5 172561 8 79571814
Sleep disorder due to a general medical condition 20.90 10.11 3 172563 14274 79557548
Brain neoplasm malignant 20.89 10.11 22 172544 1691 79570131
Procedural pain 20.84 10.11 12 172554 23072 79548750
Movement disorder 20.77 10.11 115 172451 27144 79544678
Executive dysfunction 20.74 10.11 11 172555 290 79571532
Frequent bowel movements 20.69 10.11 20 172546 29519 79542303
Coronary artery occlusion 20.69 10.11 4 172562 15311 79556511
Agnosia 20.58 10.11 10 172556 218 79571604
Psychomotor disadaptation syndrome 20.57 10.11 8 172558 99 79571723
Hypersensitivity vasculitis 20.50 10.11 46 172520 6897 79564925
Alcohol use disorder 20.48 10.11 6 172560 28 79571794
Lung disorder 20.48 10.11 97 172469 80460 79491362
Astrocytoma 20.46 10.11 10 172556 221 79571601
Mitral valve incompetence 20.41 10.11 19 172547 28546 79543276
Poverty of thought content 20.39 10.11 7 172559 59 79571763
Aspiration 20.28 10.11 92 172474 20066 79551756
Screaming 20.23 10.11 33 172533 3900 79567922
Herpes simplex encephalitis 20.23 10.11 15 172551 721 79571101
Congenital inguinal hernia 20.22 10.11 5 172561 10 79571812
Basal cell carcinoma 20.16 10.11 31 172535 37344 79534478
Adverse event 20.11 10.11 65 172501 60149 79511673
Osteomyelitis 19.99 10.11 25 172541 32840 79538982
Blister 19.92 10.11 164 172402 119312 79452510
Injection site rash 19.86 10.11 7 172559 17947 79553875
Blepharospasm 19.84 10.11 41 172525 5810 79566012
Pain in jaw 19.81 10.11 44 172522 46107 79525715
Injection site warmth 19.72 10.11 4 172562 14803 79557019
Cerebral artery stenosis 19.72 10.11 15 172551 750 79571072
Therapeutic response shortened 19.70 10.11 5 172561 15858 79555964
Dyscalculia 19.68 10.11 8 172558 112 79571710
Intestinal intraepithelial lymphocytes increased 19.65 10.11 9 172557 171 79571651
Bronchospasm 19.64 10.11 15 172551 24844 79546978
Erythema multiforme 19.62 10.11 83 172483 17568 79554254
Abdominal distension 19.60 10.11 165 172401 119485 79452337
Vitamin B6 decreased 19.60 10.11 5 172561 12 79571810
Paresis 19.59 10.11 34 172532 4227 79567595
Craniocerebral injury 19.52 10.11 38 172528 5158 79566664
Intrauterine infection 19.51 10.11 7 172559 68 79571754
Lichenoid keratosis 19.48 10.11 33 172533 4024 79567798
Gout 19.47 10.11 15 172551 24734 79547088
Catatonia 19.45 10.11 52 172514 8704 79563118
Hypocalcaemia 19.43 10.11 179 172387 49745 79522077
Injection site haemorrhage 19.37 10.11 19 172547 27851 79543971
Petechiae 19.32 10.11 92 172474 20473 79551349
Porphyria acute 19.23 10.11 20 172546 1515 79570307
Transplant rejection 19.19 10.11 9 172557 19428 79552394
Central nervous system infection 19.18 10.11 19 172547 1358 79570464
Respiratory failure 19.15 10.11 520 172046 180391 79391431
Automatism 19.14 10.11 9 172557 182 79571640
Placental infarction 19.06 10.11 8 172558 122 79571700
Angina unstable 19.06 10.11 6 172560 16521 79555301
Dysphemia 18.97 10.11 30 172536 3454 79568368
Metastases to bone 18.97 10.11 15 172551 24412 79547410
Speech disorder developmental 18.94 10.11 14 172552 670 79571152
Paraesthesia 18.92 10.11 268 172298 176055 79395767
Glycosylated haemoglobin increased 18.89 10.11 9 172557 19251 79552571
Gene mutation 18.76 10.11 26 172540 2660 79569162
Rectal haemorrhage 18.74 10.11 93 172473 76207 79495615
Conjunctival irritation 18.72 10.11 8 172558 128 79571694
Full blood count abnormal 18.71 10.11 37 172529 40437 79531385
Guillain-Barre syndrome 18.67 10.11 52 172514 8913 79562909
Juvenile myoclonic epilepsy 18.66 10.11 7 172559 78 79571744
Blood pressure systolic abnormal 18.61 10.11 7 172559 17240 79554582
Needle issue 18.55 10.11 3 172563 13065 79558757
Lipids 18.55 10.11 5 172561 16 79571806
Product dispensing error 18.51 10.11 67 172499 13196 79558626
Administration site discomfort 18.49 10.11 8 172558 132 79571690
Skin disorder 18.45 10.11 28 172538 33915 79537907
Incoherent 18.44 10.11 47 172519 7645 79564177
Sinus node dysfunction 18.40 10.11 47 172519 7654 79564168
Pregnancy on oral contraceptive 18.40 10.11 15 172551 830 79570992
Scarlet fever 18.28 10.11 8 172558 136 79571686
Squamous cell carcinoma of skin 18.26 10.11 4 172562 14029 79557793
Coagulopathy 18.24 10.11 137 172429 35869 79535953
Glaucoma 18.24 10.11 10 172556 19751 79552071
Device malfunction 18.19 10.11 12 172554 21436 79550386
Obstructive airways disorder 18.04 10.11 25 172541 31434 79540388
Pulmonary embolism 18.03 10.11 262 172304 171392 79400430
Cardiac arrest 18.03 10.11 494 172072 171602 79400220
Bile acid malabsorption 17.97 10.11 9 172557 210 79571612
Ehlers-Danlos syndrome 17.96 10.11 8 172558 142 79571680
Limb discomfort 17.96 10.11 27 172539 32823 79538999
Exostosis 17.93 10.11 7 172559 16851 79554971
Anticonvulsant drug level therapeutic 17.89 10.11 5 172561 19 79571803
Vagal nerve stimulator implantation 17.89 10.11 5 172561 19 79571803
Blood brain barrier defect 17.86 10.11 8 172558 144 79571678
Euthyroid sick syndrome 17.83 10.11 7 172559 89 79571733
Duplicate therapy error 17.78 10.11 10 172556 297 79571525
Maternal drugs affecting foetus 17.71 10.11 20 172546 1663 79570159
Selective eating disorder 17.69 10.11 10 172556 300 79571522
Bradyarrhythmia 17.67 10.11 32 172534 4114 79567708
Ocular hyperaemia 17.64 10.11 21 172545 28185 79543637
Product prescribing error 17.61 10.11 161 172405 44652 79527170
Unmasking of previously unidentified disease 17.61 10.11 22 172544 2035 79569787
Mixed anxiety and depressive disorder 17.51 10.11 11 172555 402 79571420
Inappropriate affect 17.45 10.11 19 172547 1517 79570305
Pain of skin 17.40 10.11 5 172561 14608 79557214
Gastric pH increased 17.33 10.11 6 172560 52 79571770
Frontal lobe epilepsy 17.32 10.11 4 172562 5 79571817
Loss of consciousness 17.29 10.11 481 172085 167462 79404360
Hemianopia 17.28 10.11 20 172546 1708 79570114
Respiratory tract congestion 17.14 10.11 11 172555 19943 79551879
Musculoskeletal chest pain 17.08 10.11 17 172549 24747 79547075
Priapism 16.99 10.11 33 172533 4472 79567350
Cerebellar syndrome 16.96 10.11 37 172529 5443 79566379
Burnout syndrome 16.94 10.11 10 172556 326 79571496
Systemic infection 16.91 10.11 53 172513 9699 79562123
Metastases to meninges 16.90 10.11 29 172537 3572 79568250
Ankylosing spondylitis 16.89 10.11 3 172563 12202 79559620
Musculoskeletal disorder 16.87 10.11 13 172553 21435 79550387
Epileptic psychosis 16.84 10.11 6 172560 57 79571765
Diabetic ketoacidosis 16.82 10.11 30 172536 34092 79537730
Teratogenicity 16.81 10.11 9 172557 242 79571580
Sinus arrest 16.78 10.11 29 172537 3593 79568229
Blood urea increased 16.76 10.11 52 172514 48738 79523084
Cerebral amyloid angiopathy 16.64 10.11 10 172556 337 79571485
Patent ductus arteriosus 16.61 10.11 7 172559 108 79571714
Injury 16.54 10.11 99 172467 77397 79494425
Osteochondrosis 16.53 10.11 21 172545 1975 79569847
Leukoencephalopathy 16.52 10.11 46 172520 7883 79563939
Cold sweat 16.49 10.11 10 172556 18689 79553133
Circadian rhythm sleep disorder 16.43 10.11 13 172553 689 79571133
Breath sounds abnormal 16.41 10.11 7 172559 15977 79555845
Chronic sinusitis 16.38 10.11 4 172562 13022 79558800
Right ventricular failure 16.35 10.11 16 172550 23481 79548341
Feeling cold 16.30 10.11 23 172543 28706 79543116
Personality disorder 16.26 10.11 39 172527 6107 79565715
Conjunctival hyperaemia 16.25 10.11 32 172534 4381 79567441
Pancreatitis 16.24 10.11 223 172343 68352 79503470
Fistula 16.22 10.11 4 172562 12936 79558886
Drug clearance increased 16.20 10.11 9 172557 261 79571561
Gallbladder disorder 16.16 10.11 11 172555 19329 79552493
Cholelithiasis 16.13 10.11 59 172507 52605 79519217
Product residue present 15.98 10.11 28 172538 3508 79568314
Gastritis 15.89 10.11 52 172514 47941 79523881
Post stroke depression 15.86 10.11 4 172562 9 79571813
Slow speech 15.85 10.11 23 172543 2455 79569367
Hypercholesterolaemia 15.76 10.11 16 172550 23079 79548743
Pulmonary mass 15.74 10.11 24 172542 29010 79542812
Sinus congestion 15.73 10.11 12 172554 19884 79551938
Tendonitis 15.71 10.11 17 172549 23813 79548009
Contraindicated product prescribed 15.69 10.11 19 172547 1702 79570120
Haematochezia 15.68 10.11 118 172448 87527 79484295
Fluid intake reduced 15.68 10.11 39 172527 6249 79565573
Drug-induced liver injury 15.65 10.11 215 172351 65902 79505920
Mental impairment 15.65 10.11 82 172484 18954 79552868
Hemiplegia 15.65 10.11 69 172497 14870 79556952
Clonus 15.58 10.11 41 172525 6799 79565023
Hyperkinesia 15.56 10.11 24 172542 2705 79569117
Device dislocation 15.54 10.11 20 172546 25950 79545872
SJS-TEN overlap 15.54 10.11 13 172553 746 79571076
Product administered to patient of inappropriate age 15.52 10.11 36 172530 5517 79566305
Porphyria 15.47 10.11 8 172558 200 79571622
Pyruvate kinase deficiency anaemia 15.41 10.11 3 172563 0 79571822
Ganglioglioma 15.41 10.11 3 172563 0 79571822
Emphysema 15.41 10.11 8 172558 16292 79555530
Intestinal obstruction 15.39 10.11 45 172521 42975 79528847
Laboratory test abnormal 15.38 10.11 23 172543 28025 79543797
Cryptitis 15.37 10.11 9 172557 289 79571533
COVID-19 immunisation 15.36 10.11 17 172549 1382 79570440
Dermatitis exfoliative 15.36 10.11 55 172511 10774 79561048
Anaphylactic reaction 15.34 10.11 112 172454 83631 79488191
Dysmetria 15.33 10.11 15 172551 1056 79570766
Subacute sclerosing panencephalitis 15.25 10.11 5 172561 36 79571786
Hypotonia neonatal 15.23 10.11 6 172560 77 79571745
Cytomegalovirus hepatitis 15.17 10.11 13 172553 771 79571051
Macular degeneration 15.15 10.11 3 172563 11293 79560529
Blood uric acid increased 15.14 10.11 5 172561 13355 79558467
Hypertonia 15.11 10.11 42 172524 7190 79564632
Use of accessory respiratory muscles 15.07 10.11 11 172555 516 79571306
Biopsy brain 15.03 10.11 4 172562 12 79571810
Disinhibition 15.03 10.11 23 172543 2575 79569247
Disease progression 14.97 10.11 513 172053 183849 79387973
Foot deformity 14.97 10.11 18 172548 24056 79547766
Aplasia 14.97 10.11 44 172522 7776 79564046
Acute disseminated encephalomyelitis 14.96 10.11 9 172557 304 79571518
Hiatus hernia 14.96 10.11 17 172549 23295 79548527
Retinitis viral 14.96 10.11 7 172559 140 79571682
Injection site mass 14.93 10.11 13 172553 20171 79551651
Haemorrhoids 14.92 10.11 25 172541 29103 79542719
Faeces discoloured 14.92 10.11 25 172541 29102 79542720
Niemann-Pick disease 14.90 10.11 5 172561 39 79571783
Microvillous inclusion disease 14.88 10.11 8 172558 217 79571605
Acquired macroglossia 14.88 10.11 8 172558 217 79571605
Uveitis 14.84 10.11 9 172557 16821 79555001
White matter lesion 14.77 10.11 20 172546 2002 79569820
Poor personal hygiene 14.76 10.11 11 172555 533 79571289
Hypersomnia 14.76 10.11 93 172473 22993 79548829
Hyperchloraemia 14.75 10.11 15 172551 1106 79570716
Rotator cuff syndrome 14.75 10.11 6 172560 14089 79557733
Fanconi syndrome 14.74 10.11 24 172542 2832 79568990
Cerebral cyst 14.70 10.11 10 172556 419 79571403
Cardiac murmur 14.61 10.11 8 172558 15816 79556006
Haemorrhagic transformation stroke 14.41 10.11 23 172543 2669 79569153
Flank pain 14.41 10.11 13 172553 19831 79551991
Probiotic therapy 14.39 10.11 7 172559 153 79571669
Tenderness 14.36 10.11 18 172548 23624 79548198
Autoimmune hepatitis 14.35 10.11 57 172509 11726 79560096
Hippocampal sclerosis 14.35 10.11 7 172559 154 79571668
Device leakage 14.32 10.11 3 172563 10853 79560969
Accidental exposure to product by child 14.31 10.11 24 172542 2902 79568920
Infective pulmonary exacerbation of cystic fibrosis 14.23 10.11 5 172561 12846 79558976
Paraesthesia oral 14.18 10.11 14 172552 20457 79551365
Schizophreniform disorder 14.15 10.11 7 172559 159 79571663
Vitamin B6 deficiency 14.13 10.11 9 172557 337 79571485
Gait disturbance 14.10 10.11 566 172000 206940 79364882
Irregular sleep wake rhythm disorder 14.03 10.11 9 172557 341 79571481
Parkinsonism 14.02 10.11 72 172494 16512 79555310
Cytomegalovirus gastritis 13.97 10.11 10 172556 455 79571367
Lip dry 13.94 10.11 8 172558 15410 79556412
Pharyngeal oedema 13.94 10.11 9 172557 16263 79555559
Dry skin 13.91 10.11 88 172478 67907 79503915
Hernia 13.86 10.11 10 172556 17049 79554773
Pancreatic carcinoma 13.85 10.11 6 172560 13571 79558251
Normal newborn 13.74 10.11 40 172526 7032 79564790
Febrile infection-related epilepsy syndrome 13.72 10.11 5 172561 51 79571771
Back disorder 13.72 10.11 4 172562 11574 79560248
Lower gastrointestinal haemorrhage 13.70 10.11 9 172557 16116 79555706
Twin pregnancy 13.68 10.11 13 172553 883 79570939
Consciousness fluctuating 13.67 10.11 19 172547 1950 79569872
Coronary artery stenosis 13.58 10.11 5 172561 12479 79559343
Astrocytoma, low grade 13.55 10.11 5 172561 53 79571769
Hepatitis acute 13.51 10.11 68 172498 15474 79556348
Encephalomalacia 13.49 10.11 15 172551 1226 79570596
Metastases to lymph nodes 13.46 10.11 3 172563 10394 79561428
Blood pressure diastolic abnormal 13.45 10.11 13 172553 19189 79552633
Prostatic specific antigen increased 13.44 10.11 3 172563 10383 79561439
Panniculitis 13.38 10.11 5 172561 12366 79559456
Acute encephalitis with refractory, repetitive partial seizures 13.34 10.11 3 172563 3 79571819
Intensive care unit delirium 13.30 10.11 5 172561 56 79571766
Dysgeusia 13.30 10.11 71 172495 57106 79514716
Congenital anomaly 13.23 10.11 9 172557 377 79571445
Rhinitis allergic 13.20 10.11 5 172561 12264 79559558
Polychromasia 13.19 10.11 9 172557 379 79571443
Intervertebral disc degeneration 13.16 10.11 9 172557 15776 79556046
Multiple congenital abnormalities 13.15 10.11 6 172560 113 79571709
Stereotypy 13.09 10.11 13 172553 932 79570890
Sneezing 13.02 10.11 14 172552 19669 79552153
Pregnancy with implant contraceptive 13.02 10.11 18 172548 1838 79569984
Haematuria traumatic 13.02 10.11 7 172559 190 79571632
Posture abnormal 13.00 10.11 27 172539 3839 79567983
Perseveration 13.00 10.11 9 172557 388 79571434
Cytotoxic oedema 13.00 10.11 9 172557 388 79571434
Renal tubular disorder 12.90 10.11 37 172529 6449 79565373
Tooth infection 12.90 10.11 13 172553 18819 79553003
Squamous cell carcinoma 12.90 10.11 9 172557 15613 79556209
Therapeutic product ineffective for unapproved indication 12.88 10.11 7 172559 194 79571628
Delusional disorder, mixed type 12.88 10.11 3 172563 4 79571818
Brain lobectomy 12.88 10.11 3 172563 4 79571818
Hypersexuality 12.86 10.11 17 172549 1663 79570159
Magnetic resonance imaging head abnormal 12.86 10.11 22 172544 2704 79569118
Thunderclap headache 12.84 10.11 9 172557 396 79571426
Drug dose titration not performed 12.84 10.11 12 172554 798 79571024
Synovial cyst 12.83 10.11 3 172563 10062 79561760
Cardiogenic shock 12.81 10.11 47 172519 41867 79529955
Mitochondrial cytopathy 12.74 10.11 9 172557 401 79571421
Sinus disorder 12.73 10.11 18 172548 22446 79549376
Brain injury 12.68 10.11 54 172512 11463 79560359
Erythema 12.67 10.11 377 172189 222913 79348909
Bronchiolitis 12.65 10.11 28 172538 4160 79567662
Blood osmolarity decreased 12.63 10.11 15 172551 1316 79570506
Learning disability 12.60 10.11 7 172559 203 79571619
Acquired immunodeficiency syndrome 12.57 10.11 8 172558 299 79571523
Anticonvulsant drug level abnormal 12.57 10.11 5 172561 66 79571756
Cholecystitis chronic 12.54 10.11 3 172563 9903 79561919
Restless legs syndrome 12.52 10.11 15 172551 20077 79551745
Nocturia 12.51 10.11 7 172559 13674 79558148
Abortion threatened 12.45 10.11 9 172557 416 79571406
Coma acidotic 12.43 10.11 6 172560 129 79571693
Quadriparesis 12.42 10.11 25 172541 3476 79568346
Astrocytoma malignant 12.42 10.11 4 172562 27 79571795
Unevaluable event 12.40 10.11 70 172496 55515 79516307
Gastritis erosive 12.40 10.11 4 172562 10843 79560979
Illusion 12.38 10.11 17 172549 1724 79570098
Obesity 12.38 10.11 37 172529 35088 79536734
Congestive cardiomyopathy 12.35 10.11 5 172561 11775 79560047
Device issue 12.34 10.11 25 172541 27083 79544739
Nail dystrophy 12.33 10.11 13 172553 1000 79570822
Tachycardia 12.33 10.11 486 172080 177282 79394540
Hypometabolism 12.30 10.11 6 172560 132 79571690
Myopia 12.29 10.11 18 172548 1938 79569884
Kounis syndrome 12.23 10.11 28 172538 4254 79567568
Dysgraphia 12.23 10.11 27 172539 4005 79567817
Salivary hypersecretion 12.20 10.11 62 172504 14162 79557660
Meningitis 12.20 10.11 47 172519 9535 79562287
Upper-airway cough syndrome 12.20 10.11 5 172561 11688 79560134
Amniorrhexis 12.17 10.11 4 172562 29 79571793
Metastases to liver 12.15 10.11 27 172539 28287 79543535
Impulse-control disorder 12.14 10.11 17 172549 1757 79570065
Blood urine present 12.14 10.11 17 172549 21280 79550542
Congenital renal cyst 12.13 10.11 3 172563 6 79571816
Gerstmann's syndrome 12.13 10.11 3 172563 6 79571816
Alcoholic seizure 12.13 10.11 3 172563 6 79571816
Interstitial lung disease 12.12 10.11 171 172395 112429 79459393
Metastatic malignant melanoma 12.08 10.11 22 172544 2841 79568981
Primary mediastinal large B-cell lymphoma 12.06 10.11 4 172562 30 79571792
COVID-19 pneumonia 11.98 10.11 28 172538 28821 79543001
Medication error 11.97 10.11 212 172354 68430 79503392
Precocious puberty 11.93 10.11 8 172558 327 79571495
Autoimmune disorder 11.92 10.11 11 172555 16601 79555221
Violence-related symptom 11.91 10.11 11 172555 720 79571102
Exomphalos 11.87 10.11 5 172561 77 79571745
Oligodendroglioma 11.86 10.11 6 172560 143 79571679
Cerebral haematoma 11.84 10.11 41 172525 7901 79563921
Lower limb fracture 11.82 10.11 20 172546 23195 79548627
Illogical thinking 11.81 10.11 5 172561 78 79571744
Dysphagia 11.79 10.11 347 172219 121789 79450033
Dropped head syndrome 11.78 10.11 8 172558 334 79571488
Primary mediastinal large B-cell lymphoma recurrent 11.75 10.11 5 172561 79 79571743
Joint effusion 11.71 10.11 13 172553 18001 79553821
Electrocardiogram QT prolonged 11.70 10.11 267 172299 90119 79481703
Urinary tract stoma complication 11.70 10.11 5 172561 80 79571742
Hyperlipasaemia 11.69 10.11 14 172552 1240 79570582
Impaired self-care 11.67 10.11 21 172545 2686 79569136
Migraine 11.63 10.11 127 172439 87366 79484456
Neoplasm malignant 11.58 10.11 33 172533 31777 79540045
Laryngeal stenosis 11.57 10.11 13 172553 1075 79570747
Bradypnoea 11.53 10.11 34 172532 6018 79565804
Treatment failure 11.45 10.11 281 172285 170205 79401617
Cerebral venous thrombosis 11.42 10.11 21 172545 2732 79569090
Lipids abnormal 11.42 10.11 10 172556 611 79571211
Hyperpyrexia 11.40 10.11 34 172532 6058 79565764
Urge incontinence 11.37 10.11 13 172553 1095 79570727
Neuroleptic malignant syndrome 11.33 10.11 100 172466 27459 79544363
Toothache 11.32 10.11 16 172550 19954 79551868
Chemotherapeutic drug level above therapeutic 11.32 10.11 5 172561 87 79571735
Respiratory syncytial virus bronchiolitis 11.31 10.11 9 172557 481 79571341
Eye irritation 11.30 10.11 17 172549 20664 79551158
Congenital hydronephrosis 11.28 10.11 3 172563 9 79571813
Therapeutic response changed 11.27 10.11 14 172552 1287 79570535
Drug withdrawal headache 11.27 10.11 5 172561 88 79571734
Pemphigoid 11.26 10.11 64 172502 15251 79556571
Vasogenic cerebral oedema 11.26 10.11 15 172551 1478 79570344
Jaundice 11.24 10.11 170 172396 53179 79518643
Spinal osteoarthritis 11.24 10.11 12 172554 16915 79554907
CSF virus identified 11.23 10.11 4 172562 38 79571784
Myositis 11.22 10.11 15 172551 19153 79552669
Crystalluria 11.22 10.11 12 172554 939 79570883
Tuberous sclerosis complex 11.21 10.11 5 172561 89 79571733
Disorganised speech 11.21 10.11 18 172548 2099 79569723
Teratoma 11.19 10.11 6 172560 162 79571660
Aphthous ulcer 11.19 10.11 12 172554 16877 79554945
Colon cancer 11.18 10.11 9 172557 14514 79557308
Oesophageal carcinoma 11.15 10.11 5 172561 11079 79560743
Encephalitis viral 11.11 10.11 20 172546 2559 79569263
Cytomegalovirus viraemia 11.11 10.11 7 172559 12814 79559008
Fracture 11.07 10.11 83 172483 21718 79550104
Apallic syndrome 11.04 10.11 12 172554 956 79570866
High-pitched crying 11.04 10.11 3 172563 10 79571812
Orthopnoea 11.02 10.11 4 172562 10069 79561753
Underdose 11.01 10.11 115 172451 33036 79538786
Tricuspid valve incompetence 10.97 10.11 16 172550 19696 79552126
Large granular lymphocytosis 10.97 10.11 8 172558 375 79571447
Karyotype analysis abnormal 10.96 10.11 4 172562 41 79571781
Hyporeflexia 10.94 10.11 24 172542 3544 79568278
Pyelonephritis 10.91 10.11 17 172549 20371 79551451
Mean cell volume increased 10.86 10.11 34 172532 6219 79565603
Apoptosis 10.84 10.11 9 172557 511 79571311
Ovarian cyst 10.84 10.11 7 172559 12648 79559174
Abdominal pain lower 10.83 10.11 34 172532 31748 79540074
Transverse sinus thrombosis 10.83 10.11 10 172556 655 79571167
Intrusive thoughts 10.78 10.11 9 172557 515 79571307
Glycosuria 10.77 10.11 18 172548 2170 79569652
Intracranial pressure increased 10.74 10.11 41 172525 8281 79563541
Aortic arteriosclerosis 10.72 10.11 3 172563 8915 79562907
Carnitine deficiency 10.71 10.11 7 172559 274 79571548
Serum ferritin increased 10.71 10.11 46 172520 9801 79562021
Clumsiness 10.71 10.11 22 172544 3105 79568717
Food allergy 10.70 10.11 5 172561 10819 79561003
Adverse drug reaction 10.67 10.11 92 172474 66300 79505522
Encephalocele 10.63 10.11 4 172562 45 79571777
Eyelid injury 10.61 10.11 3 172563 12 79571810
Sinus bradycardia 10.58 10.11 92 172474 25155 79546667
Sialoadenitis 10.58 10.11 17 172549 1984 79569838
Autoimmune encephalopathy 10.55 10.11 5 172561 103 79571719
Acute myeloid leukaemia 10.55 10.11 33 172533 30852 79540970
Renal disorder 10.52 10.11 51 172515 42054 79529768
Anti-GAD antibody positive 10.47 10.11 4 172562 47 79571775
Prolonged pregnancy 10.47 10.11 4 172562 47 79571775
Psychotic symptom 10.47 10.11 20 172546 2677 79569145
Sexually inappropriate behaviour 10.47 10.11 9 172557 536 79571286
Onychophagia 10.46 10.11 5 172561 105 79571717
Weight gain poor 10.46 10.11 12 172554 1015 79570807
Unintended pregnancy 10.45 10.11 25 172541 3908 79567914
Pulmonary function test 10.42 10.11 3 172563 13 79571809
Lymphocyte count 10.42 10.11 3 172563 13 79571809
Rales 10.40 10.11 17 172549 19984 79551838
Swollen tongue 10.39 10.11 52 172514 42518 79529304
Temperature intolerance 10.37 10.11 4 172562 9701 79562121
Facial pain 10.35 10.11 7 172559 12343 79559479
Tinnitus 10.34 10.11 55 172511 44278 79527544
Mucocutaneous rash 10.32 10.11 4 172562 49 79571773
Hyperlipidaemia 10.30 10.11 26 172540 26067 79545755
Lymphocyte adoptive therapy 10.24 10.11 3 172563 14 79571808
Attention-seeking behaviour 10.21 10.11 5 172561 111 79571711
Vertigo 10.20 10.11 208 172358 68874 79502948
Groin pain 10.20 10.11 8 172558 13072 79558750
Diverticulum intestinal 10.15 10.11 3 172563 8602 79563220
Blood ketone body increased 10.13 10.11 10 172556 712 79571110
Spinal pain 10.12 10.11 11 172555 15381 79556441

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 41.53 25.29 63 1265 989 87475
Weight gain poor 40.25 25.29 21 1307 61 88403
Brain malformation 38.80 25.29 12 1316 0 88464
Cerebral cyst 29.29 25.29 12 1316 15 88449
Gastrooesophageal reflux disease 28.46 25.29 12 1316 17 88447
Off label use 27.19 25.29 40 1288 606 87858

Pharmacologic Action:

SourceCodeDescription
ATC N03AX14 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Other antiepileptics
FDA PE N0000008486 Decreased Central Nervous System Disorganized Electrical Activity
MeSH PA D000927 Anticonvulsants
MeSH PA D002491 Central Nervous System Agents
MeSH PA D018697 Nootropic Agents
CHEBI has role CHEBI:35623 anticonvulsants
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Status epilepticus indication 230456007 DOID:1824
Epilepsy characterized by intractable complex partial seizures indication 442481002
Simple partial seizure indication 117891000119100
Partial Epilepsy Treatment Adjunct indication
Tonic-Clonic Epilepsy Treatment Adjunct indication
Myoclonic Epilepsy Adjunct Treatment indication
Suicidal thoughts contraindication 6471006
Hallucinations contraindication 7011001
Mood swings contraindication 18963009
Ataxia contraindication 20262006
Indifference contraindication 20602000
Abnormal gait contraindication 22325002
Feeling agitated contraindication 24199005
Depressive disorder contraindication 35489007
Anxiety contraindication 48694002
Feeling irritable contraindication 55929007
Aggressive behavior contraindication 61372001
Psychotic disorder contraindication 69322001
Hostile behavior contraindication 79351003
Depersonalization contraindication 79499004
Fatigue contraindication 84229001
Leukopenia contraindication 84828003 DOID:615
Kidney disease contraindication 90708001 DOID:557
Pancytopenia contraindication 127034005 DOID:12450
Disease of liver contraindication 235856003 DOID:409
Drowsy contraindication 271782001
Neutropenic disorder contraindication 303011007 DOID:1227
Behavioral Disorders contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.66 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
1GM SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9339489 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM
1GM SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM
1GM SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM UNDER FASTED CONDITIONS
1GM SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM UNDER FED CONDITIONS
250MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9339489 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM
250MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM
250MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM UNDER FASTED CONDITIONS
250MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM UNDER FED CONDITIONS
500MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9339489 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM
500MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM
500MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM UNDER FASTED CONDITIONS
500MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM UNDER FED CONDITIONS
750MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9339489 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM
750MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM
750MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM UNDER FASTED CONDITIONS
750MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM UNDER FED CONDITIONS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Synaptic vesicle glycoprotein 2A Transporter MODULATOR Ki 6.10 CHEMBL CHEMBL
Sodium channel protein type 1 subunit alpha Ion channel WOMBAT-PK
Voltage-dependent T-type calcium channel subunit alpha-1G Ion channel WOMBAT-PK
Carbonic anhydrase 1 Enzyme WOMBAT-PK
Synaptic vesicle glycoprotein 2A Unclassified INHIBITOR IC50 6.10 IUPHAR

External reference:

IDSource
D00709 KEGG_DRUG
4021198 VANDF
C0377265 UMLSCUI
CHEBI:6437 CHEBI
CHEMBL1286 ChEMBL_ID
DB01202 DRUGBANK_ID
D000077287 MESH_DESCRIPTOR_UI
5284583 PUBCHEM_CID
6450 INN_ID
6826 IUPHAR_LIGAND_ID
44YRR34555 UNII
114477 RXNORM
31546 MMSL
66397 MMSL
8574 MMSL
d04499 MMSL
008058 NDDF
116076009 SNOMEDCT_US
387000003 SNOMEDCT_US
CHEMBL1400561 ChEMBL_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0121-0799 SOLUTION 100 mg ORAL ANDA 27 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0121-0799 SOLUTION 100 mg ORAL ANDA 27 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0121-0799 SOLUTION 100 mg ORAL ANDA 27 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0121-1598 SOLUTION 1000 mg ORAL ANDA 27 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0121-1598 SOLUTION 1000 mg ORAL ANDA 27 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0121-1598 SOLUTION 1000 mg ORAL ANDA 27 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0121-2397 SOLUTION 1500 mg ORAL ANDA 27 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0121-2397 SOLUTION 1500 mg ORAL ANDA 27 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0121-2397 SOLUTION 1500 mg ORAL ANDA 27 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0121-4799 SOLUTION 500 mg ORAL ANDA 27 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0121-4799 SOLUTION 500 mg ORAL ANDA 27 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0121-4799 SOLUTION 500 mg ORAL ANDA 27 sections
LEVETIRACETAM HUMAN PRESCRIPTION DRUG LABEL 1 0121-4802 SOLUTION 100 mg ORAL ANDA 27 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0143-9574 INJECTION 100 mg INTRAVENOUS ANDA 26 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0143-9673 INJECTION 100 mg INTRAVENOUS ANDA 26 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0143-9673 INJECTION 100 mg INTRAVENOUS ANDA 26 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0378-5613 TABLET, FILM COATED 250 mg ORAL ANDA 29 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0378-5613 TABLET, FILM COATED 250 mg ORAL ANDA 29 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0378-5615 TABLET, FILM COATED 500 mg ORAL ANDA 29 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0378-5615 TABLET, FILM COATED 500 mg ORAL ANDA 29 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0378-5617 TABLET, FILM COATED 750 mg ORAL ANDA 29 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0378-5617 TABLET, FILM COATED 750 mg ORAL ANDA 29 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0378-5619 TABLET, FILM COATED 1000 mg ORAL ANDA 29 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0378-5619 TABLET, FILM COATED 1000 mg ORAL ANDA 29 sections
LEVETIRACETAM HUMAN PRESCRIPTION DRUG LABEL 1 0409-1886 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 28 sections
LEVETIRACETAM HUMAN PRESCRIPTION DRUG LABEL 1 0409-1886 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 28 sections
LEVETIRACETAM HUMAN PRESCRIPTION DRUG LABEL 1 0409-1886 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 28 sections
LEVETIRACETAM HUMAN PRESCRIPTION DRUG LABEL 1 0409-1886 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 28 sections
LEVETIRACETAM HUMAN PRESCRIPTION DRUG LABEL 1 0409-2011 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 28 sections
LEVETIRACETAM HUMAN PRESCRIPTION DRUG LABEL 1 0409-2011 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 28 sections