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levamisole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	1561	14769-73-4

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: levamisole hydrochloride levamisole tetramisole levamisol levamizol tetramisole hydrochloride levamisole HCl tetramisole HCl levamisole phosphate levamisole resinate	An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6) Molecular weight: 204.29 Formula: C11H12N2S CLOGP: 1.84 LIPINSKI: 0 HAC: 2 HDO: 0 TPSA: 15.60 ALOGS: -2.15 ROTB: 1 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

levamisole hydrochloride
levamisole
tetramisole
levamisol
levamizol
tetramisole hydrochloride
levamisole HCl
tetramisole HCl
levamisole phosphate
levamisole resinate

An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6)

Molecular weight: 204.29
Formula: C11H12N2S
CLOGP: 1.84
LIPINSKI: 0
HAC: 2
HDO: 0
TPSA: 15.60
ALOGS: -2.15
ROTB: 1

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.15	g	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	4.08 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	65 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
June 18, 1990	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxicity to various agents	135.00	101.18	42	141	247208	63241631

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxicity to various agents	277.49	92.96	111	547	200251	34756022
Drug abuse	196.79	92.96	72	586	99024	34857249

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxicity to various agents	369.77	85.55	143	699	421397	79322149
Drug abuse	276.89	85.55	91	751	162600	79580946

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	P02CE01	ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ANTHELMINTICS ANTINEMATODAL AGENTS Imidazothiazole derivatives
MeSH PA	D000276	Adjuvants, Immunologic
MeSH PA	D000871	Anthelmintics
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000969	Antinematodal Agents
MeSH PA	D000977	Antiparasitic Agents
MeSH PA	D018501	Antirheumatic Agents
MeSH PA	D007155	Immunologic Factors
CHEBI has role	CHEBI:35444	antinematodal drugs
CHEBI has role	CHEBI:35842	anti-rheumatic drugs
CHEBI has role	CHEBI:50846	Immunologic factor
CHEBI has role	CHEBI:50847	Immunologic adjuvant
CHEBI has role	CHEBI:63332	alkaline phosphatase inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Ascariasis	indication	2435008	DOID:456
Ancylostomiasis	indication	63479002	DOID:12841

🐶 Veterinary Drug Use

Species	Use	Relation
Cattle	Nematode infections, removal of stomach worms, Haemonchus	Indication
Cattle	Nematode infections, removal of intestinal worms, Trichostrongylus	Indication
Cattle	Nematode infections, removal of lungworms, Dictyocaulus	Indication
Cattle	Nematode infections, removal of intestinal worms, Cooperia	Indication
Cattle	Nematode infections, removal of intestinal worms, Nematodirus	Indication
Cattle	Nematode infections, removal of intestinal worms, Bunostomum	Indication
Cattle	Nematode infections, removal of intestinal worms, Oesophagostomum	Indication
Cattle	Nematode infections, removal of stomach worms, Trichostrongylus	Indication
Cattle	Nematode infections, removal of stomach worms, Ostertagia	Indication
Sheep	Nematode infections, removal of stomach worms, Haemonchus	Indication
Sheep	Nematode infections, removal of intestinal worms, Trichostrongylus	Indication
Sheep	Nematode infections, removal of lungworms, Dictyocaulus	Indication
Sheep	Nematode infections, removal of intestinal worms, Cooperia	Indication
Sheep	Nematode infections, removal of intestinal worms, Nematodirus	Indication
Sheep	Nematode infections, removal of intestinal worms, Bunostomum	Indication
Sheep	Nematode infections, removal of intestinal worms, Oesophagostomum	Indication
Sheep	Nematode infections, removal of stomach worms, Trichostrongylus	Indication
Sheep	Nematode infections, removal of stomach worms, Ostertagia	Indication
Swine	Nematode infections, removal of large roundworms, Ascaris suum	Indication
Swine	Nematode infections, removal of nodular worms, Oesophagostomum species	Indication
Swine	Nematode infections, removal of lungworms, Metastrongylus species	Indication
Swine	Nematode infections, removal of intestinal threadworms, Strongyloides ransomi	Indication
Swine	Nematode infections, removal of kidney worms, Stephanurus dentatus	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
Ripercol L Bolus, Tramisol Cattle Wormer Bolus	Zoetis Inc.	1
Ripercol L Soluble Drench Powder	Zoetis Inc.	1
Ripercol L, Tramisol Soluble Drench Powder for Sheep	Zoetis Inc.	1
Ripercol L Wormer Oblets, Tramisol Sheep Wormer Oblets	Zoetis Inc.	1
Ripercol L	Zoetis Inc.	1
Ripercol L	Zoetis Inc.	1
Levasole Cattle Wormer Bolus	Intervet Inc.	1
Ripercol L-Piperazine Soluble	Zoetis Inc.	2
Ripercol L-Piperazine	Zoetis Inc.	2
Tramisol Injectable Solution	Zoetis Inc.	1
Tramisol	Zoetis Inc.	1
Levasole Soluble Pig Wormer	Intervet Inc.	1
Levasole	Intervet Inc.	1
Levamisole Soluble Drench Powder, Levasole, Levasole Soluble Drench Powder, Tramisol Soluble Drench Powder	Intervet Inc.	1
Levasole Sheep Wormer Bolus, Tramisole Sheep Wormer Oblets Tablets	Intervet Inc.	1
Tramisol Gel	Zoetis Inc.	1
Levasole Injectable Solution	Intervet Inc.	1
Tramisol-X-Tra Cattle Anthelmintic and Extoparasitic Paste	Intervet Inc.	2
Totalon Topical Cattle Anthelmintic	Intervet Inc.	1
Tramisol Pour-On	Zoetis Inc.	1
Prohibit Soluble Drench Powder	Huvepharma EOOD	1
Levamisole Phosphate	Huvepharma EOOD	1
LevaMed	Bimeda Animal Health Limited	1
LevaMed Soluble Drench Powder	Bimeda Animal Health Limited	1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.2	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Alkaline phosphatase, tissue-nonspecific isozyme	Enzyme	P05186	PPBT_HUMAN		Ki	4.80	CHEMBL
Intestinal-type alkaline phosphatase	Enzyme	P09923	PPBI_HUMAN		IC50	4.69	CHEMBL
Nicotinic acetylcholine receptor alpha subunit	Ion channel		O96760_ASCSU	AGONIST			CHEMBL	CHEMBL
Acetylcholine receptor subunit alpha-type unc-63	Ion channel		ACH6_CAEEL				WOMBAT-PK
Membrane-associated progesterone receptor component 1	Membrane receptor		PGRC1_RAT		Ki	5.57	DRUG MATRIX
Alkaline phosphatase, tissue-nonspecific isozyme	Enzyme		PPBT_BOVIN		IC50	4.72	CHEMBL

External reference:

ID	Source
D00750	KEGG_DRUG
16595-80-5	SECONDARY_CAS_RN
5036-02-2	SECONDARY_CAS_RN
4019531	VANDF
C0023556	UMLSCUI
CHEBI:6432	CHEBI
CHEMBL1454	ChEMBL_ID
DB00848	DRUGBANK_ID
CHEMBL1770	ChEMBL_ID
CHEMBL277775	ChEMBL_ID
D007978	MESH_DESCRIPTOR_UI
26879	PUBCHEM_CID
7210	IUPHAR_LIGAND_ID
2643	INN_ID
5086-74-8	SECONDARY_CAS_RN
2880D3468G	UNII
DB16561	DRUGBANK_ID
1535214	RXNORM
4967	MMSL
d00276	MMSL
003546	NDDF
004809	NDDF
387296006	SNOMEDCT_US
54391004	SNOMEDCT_US
81365005	SNOMEDCT_US
96118005	SNOMEDCT_US
D013773	MESH_DESCRIPTOR_UI
CHEMBL554891	ChEMBL_ID
1973	INN_ID
32093-35-9	SECONDARY_CAS_RN

Pharmaceutical products:

None