leflunomide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1552 75706-12-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • leflunomide medac
  • leflunomide
  • arava
  • avara
  • leflunomida
  • leflunomidum
  • lefumide
  • repso
An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
  • Molecular weight: 270.21
  • Formula: C12H9F3N2O2
  • CLOGP: 2.36
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 55.13
  • ALOGS: -3.51
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.02 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.23 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 80 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
fu (Fraction unbound in plasma) 0.00 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Approvals:

DateAgencyCompanyOrphan
Sept. 2, 1999 EMA Sanofi-aventis Deutschland GmbH
Sept. 10, 1998 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 6652.86 14.64 18828 417845 1025937 62026412
Drug intolerance 5071.13 14.64 8218 428455 300443 62751906
Contraindicated product administered 4291.84 14.64 6310 430363 211338 62841011
Joint swelling 3787.29 14.64 7487 429186 320179 62732170
Rheumatoid arthritis 3725.76 14.64 6431 430242 247388 62804961
Synovitis 3113.05 14.64 5015 431658 181903 62870446
Treatment failure 3022.84 14.64 5123 431550 193920 62858429
Arthropathy 2745.07 14.64 5396 431277 229396 62822953
Therapeutic product effect decreased 2494.84 14.64 4633 432040 188554 62863795
Pemphigus 2378.22 14.64 4411 432262 179315 62873034
Systemic lupus erythematosus 2196.10 14.64 4596 432077 204322 62848027
Abdominal discomfort 2059.19 14.64 5834 430839 315051 62737298
Swelling 2038.34 14.64 5278 431395 270100 62782249
Glossodynia 1967.15 14.64 4010 432663 174866 62877483
Hand deformity 1957.75 14.64 3744 432929 155713 62896636
Alopecia 1896.26 14.64 5854 430819 331682 62720667
Pain 1584.42 14.64 9574 427099 731054 62321295
Death 1530.18 14.64 351 436322 374030 62678319
Hepatic enzyme increased 1397.42 14.64 3782 432891 198546 62853803
Arthralgia 1301.07 14.64 7498 429175 562212 62490137
Anti-cyclic citrullinated peptide antibody positive 1273.36 14.64 2603 434070 113609 62938740
Wound 1241.33 14.64 3164 433509 160099 62892250
Hypersensitivity 1131.18 14.64 4489 432184 288196 62764153
Rheumatoid factor positive 1111.80 14.64 2044 434629 82362 62969987
Acute kidney injury 1065.44 14.64 252 436421 263163 62789186
Pericarditis 1033.18 14.64 2582 434091 128997 62923352
Hypotension 1031.71 14.64 298 436375 272306 62780043
Peripheral swelling 1020.11 14.64 4070 432603 261872 62790477
Musculoskeletal stiffness 1012.40 14.64 3179 433494 181439 62870910
Drug hypersensitivity 938.97 14.64 4425 432248 306262 62746087
Constipation 929.87 14.64 205 436468 224738 62827611
Toxicity to various agents 926.87 14.64 275 436398 246975 62805374
Therapeutic product effect incomplete 918.40 14.64 2393 434280 122663 62929686
Discomfort 916.50 14.64 2881 433792 164493 62887856
Rash 910.35 14.64 6779 429894 554092 62498257
Completed suicide 908.70 14.64 19 436654 145654 62906695
C-reactive protein abnormal 908.25 14.64 1339 435334 44757 63007592
Drug interaction 807.19 14.64 284 436389 228847 62823502
Anaemia 794.23 14.64 521 436152 292909 62759440
Folliculitis 776.68 14.64 1581 435092 68736 62983613
Muscle injury 767.01 14.64 1507 435166 63838 62988511
Psoriatic arthropathy 742.36 14.64 1819 434854 89701 62962648
Infection 734.39 14.64 3322 433351 225851 62826498
Product use issue 731.00 14.64 3229 433444 217291 62835058
Impaired healing 725.97 14.64 1936 434737 100606 62951743
Irritable bowel syndrome 713.57 14.64 1680 434993 80732 62971617
Gastrointestinal disorder 712.52 14.64 2253 434420 128986 62923363
Infusion related reaction 704.87 14.64 3447 433226 242074 62810275
Helicobacter infection 704.13 14.64 1798 434875 90987 62961362
Febrile neutropenia 696.41 14.64 27 436646 118422 62933927
Lower respiratory tract infection 683.48 14.64 2233 434440 130074 62922275
Duodenal ulcer perforation 676.38 14.64 1704 434969 85505 62966844
Dehydration 643.57 14.64 196 436477 173158 62879191
Ill-defined disorder 637.73 14.64 1601 435072 80154 62972195
Red blood cell sedimentation rate abnormal 636.20 14.64 732 435941 19050 63033299
Loss of personal independence in daily activities 616.42 14.64 1764 434909 95526 62956823
Hyponatraemia 575.42 14.64 53 436620 111847 62940502
Blister 574.38 14.64 2081 434592 127733 62924616
Red blood cell sedimentation rate increased 573.58 14.64 1061 435612 42921 63009428
Tremor 572.14 14.64 108 436565 132131 62920218
Product dose omission issue 567.65 14.64 467 436206 233846 62818503
Condition aggravated 560.17 14.64 4697 431976 397520 62654829
Seizure 555.69 14.64 117 436556 132517 62919832
Sleep disorder due to general medical condition, insomnia type 544.73 14.64 1147 435526 51070 63001279
Maternal exposure during pregnancy 532.57 14.64 2947 433726 217115 62835234
Somnolence 529.96 14.64 284 436389 178401 62873948
Fall 514.09 14.64 1218 435455 391116 62661233
C-reactive protein increased 501.12 14.64 1612 435061 93095 62959254
Disease progression 488.85 14.64 121 436552 122637 62929712
Intentional overdose 473.28 14.64 7 436666 74145 62978204
Overdose 462.98 14.64 111 436562 114967 62937382
Cardiac arrest 454.66 14.64 52 436621 92493 62959856
Anxiety 450.42 14.64 499 436174 217042 62835307
Urinary tract infection 445.26 14.64 708 435965 263976 62788373
Dizziness 444.80 14.64 1495 435178 428430 62623919
Bradycardia 436.22 14.64 15 436658 73212 62979137
Mobility decreased 430.70 14.64 1813 434860 119346 62933003
Thrombocytopenia 424.18 14.64 257 436416 150900 62901449
Bone erosion 416.13 14.64 560 436113 17157 63035192
Dyspnoea 414.89 14.64 2757 433916 658556 62393793
Knee arthroplasty 406.42 14.64 1046 435627 53160 62999189
Rheumatoid nodule 404.09 14.64 543 436130 16612 63035737
Neutropenia 387.48 14.64 379 436294 174626 62877723
Hypokalaemia 380.36 14.64 120 436553 103684 62948665
Electrocardiogram QT prolonged 366.27 14.64 9 436664 59521 62992828
Sepsis 361.02 14.64 313 436360 152810 62899539
Tachycardia 354.33 14.64 185 436488 117971 62934378
Blood iron abnormal 347.55 14.64 255 436418 3621 63048728
Chest discomfort 346.68 14.64 161 436512 109808 62942541
Hip arthroplasty 344.44 14.64 907 435766 46739 63005610
Stomatitis 340.03 14.64 1865 434808 136860 62915489
Depressed level of consciousness 331.21 14.64 25 436648 62053 62990296
Vision blurred 326.71 14.64 112 436561 91812 62960537
Suicide attempt 326.53 14.64 24 436649 60894 62991455
Blood cholesterol increased 320.11 14.64 1389 435284 92643 62959706
Balance disorder 319.43 14.64 92 436581 84330 62968019
Platelet count decreased 304.56 14.64 213 436460 115909 62936440
Rheumatic fever 303.84 14.64 813 435860 42298 63010051
Abdominal pain 303.38 14.64 1020 435653 292436 62759913
Oedema peripheral 301.72 14.64 525 436148 188986 62863363
Osteoarthritis 300.91 14.64 1377 435296 93966 62958383
Foot deformity 292.92 14.64 614 436059 27239 63025110
Hyperkalaemia 291.54 14.64 21 436652 54182 62998167
Pulmonary embolism 288.00 14.64 228 436445 116456 62935893
Atrial fibrillation 285.25 14.64 230 436443 116406 62935943
Inflammation 285.16 14.64 1222 435451 81051 62971298
Swollen joint count increased 281.94 14.64 707 435966 35347 63017002
Respiratory failure 281.76 14.64 176 436497 101682 62950667
Cough 272.50 14.64 1063 435610 291680 62760669
Cardio-respiratory arrest 272.34 14.64 43 436630 59916 62992433
Hallucination 271.23 14.64 30 436643 54787 62997562
Cerebrovascular accident 270.50 14.64 208 436465 107816 62944533
Sinusitis 270.38 14.64 2561 434112 224092 62828257
Agitation 266.62 14.64 45 436628 59712 62992637
Neutrophil count decreased 266.51 14.64 36 436637 56370 62995979
Hypoglycaemia 261.95 14.64 48 436625 60017 62992332
Asthenia 259.98 14.64 1560 435113 382044 62670305
Epistaxis 259.48 14.64 88 436585 72637 62979712
Muscle spasms 257.34 14.64 423 436250 155727 62896622
Cognitive disorder 255.84 14.64 39 436634 55776 62996573
COVID-19 254.84 14.64 241 436432 112862 62939487
Deformity 251.34 14.64 354 436319 11330 63041019
Gastrointestinal haemorrhage 250.99 14.64 122 436551 81054 62971295
Fibromyalgia 247.46 14.64 1153 435520 79267 62973082
Tenosynovitis 246.42 14.64 383 436290 13412 63038937
Sedation 246.20 14.64 4 436669 38805 63013544
Hypoxia 245.74 14.64 55 436618 59737 62992612
Osteoporosis 243.91 14.64 908 435765 56430 62995919
Metabolic acidosis 243.72 14.64 17 436656 45052 63007297
Cardiac failure congestive 243.09 14.64 169 436504 92264 62960085
Chest pain 241.02 14.64 725 435948 215234 62837115
Blood glucose increased 239.66 14.64 139 436534 83617 62968732
Haemoglobin decreased 238.90 14.64 395 436278 145090 62907259
Drug tolerance decreased 235.91 14.64 428 436245 17045 63035304
Arthritis 234.56 14.64 1482 435191 114439 62937910
Musculoskeletal disorder 233.50 14.64 469 436204 20175 63032174
Wrong technique in product usage process 232.05 14.64 70 436603 62270 62990079
Pulmonary fibrosis 231.08 14.64 700 435973 39109 63013240
Syncope 229.06 14.64 282 436391 117103 62935246
Hyperhidrosis 227.82 14.64 243 436430 107593 62944756
Cardiac failure 225.27 14.64 170 436503 88972 62963377
Myalgia 224.12 14.64 416 436257 146113 62906236
Joint range of motion decreased 220.93 14.64 604 436069 31824 63020525
Pancytopenia 219.00 14.64 206 436467 96727 62955622
Lactic acidosis 217.48 14.64 11 436662 38276 63014073
Dysphagia 216.19 14.64 175 436498 88410 62963939
Renal failure 215.82 14.64 296 436377 117356 62934993
Flushing 212.87 14.64 126 436547 74961 62977388
Unresponsive to stimuli 212.39 14.64 4 436669 33812 63018537
Feeling abnormal 209.12 14.64 442 436231 147950 62904399
Disability 206.53 14.64 416 436257 17931 63034418
Bone pain 205.85 14.64 60 436613 54581 62997768
Chills 205.21 14.64 288 436385 113090 62939259
Plasma cell myeloma 204.95 14.64 10 436663 35895 63016454
Granuloma skin 204.74 14.64 271 436402 8166 63044183
Coma 204.73 14.64 93 436580 64271 62988078
Nausea 201.62 14.64 4415 432258 850056 62202293
White blood cell count decreased 200.51 14.64 409 436264 138695 62913654
Mental status changes 200.20 14.64 20 436653 39579 63012770
Blood parathyroid hormone decreased 199.37 14.64 289 436384 9502 63042847
Pneumonia aspiration 199.17 14.64 9 436664 34531 63017818
Adverse event 198.64 14.64 956 435717 66603 62985746
Joint stiffness 198.48 14.64 687 435986 41182 63011167
International normalised ratio increased 198.40 14.64 39 436634 46386 63005963
Panniculitis 197.67 14.64 312 436361 11073 63041276
Neuropathy peripheral 194.72 14.64 300 436373 113367 62938982
Pleural effusion 193.60 14.64 213 436460 92997 62959352
Liver injury 192.30 14.64 876 435797 59644 62992705
Therapeutic response decreased 192.13 14.64 886 435787 60639 62991710
Lethargy 190.90 14.64 73 436600 55934 62996415
Pulmonary oedema 187.90 14.64 71 436602 54802 62997547
Respiratory arrest 186.63 14.64 9 436664 32636 63019713
Gastrooesophageal reflux disease 186.32 14.64 230 436443 95409 62956940
Deep vein thrombosis 184.75 14.64 182 436491 83618 62968731
Hyperglycaemia 183.55 14.64 33 436640 41834 63010515
Blood pressure decreased 181.67 14.64 111 436562 64911 62987438
Vomiting 181.62 14.64 2733 433940 556884 62495465
Encephalopathy 181.61 14.64 25 436648 38595 63013754
Deafness transitory 177.52 14.64 130 436543 1840 63050509
Rhabdomyolysis 177.47 14.64 42 436631 43909 63008440
Grip strength decreased 176.29 14.64 439 436234 21848 63030501
Finger deformity 176.08 14.64 241 436432 7504 63044845
Nasopharyngitis 174.44 14.64 2584 434089 251673 62800676
Disturbance in attention 174.30 14.64 27 436646 38162 63014187
Orthostatic hypotension 173.41 14.64 22 436651 36138 63016211
Fluid retention 167.99 14.64 101 436572 59585 62992764
Asthma 165.81 14.64 397 436276 127164 62925185
Type 2 diabetes mellitus 164.70 14.64 871 435802 62997 62989352
Intentional product misuse 164.68 14.64 108 436565 60809 62991540
Dysarthria 164.41 14.64 45 436628 42666 63009683
Adverse drug reaction 164.23 14.64 1024 435649 78690 62973659
Restlessness 162.53 14.64 10 436663 29443 63022906
Ascites 162.34 14.64 40 436633 40688 63011661
Intentional self-injury 161.48 14.64 3 436670 25684 63026665
Diarrhoea 161.39 14.64 3721 432952 711645 62340704
Decreased appetite 157.95 14.64 1044 435629 250008 62802341
Drug withdrawal syndrome 157.08 14.64 7 436666 27187 63025162
Premature delivery 156.52 14.64 14 436659 30267 63022082
Dry skin 156.31 14.64 99 436574 56788 62995561
Palpitations 154.61 14.64 341 436332 112429 62939920
Depression 154.39 14.64 760 435913 195732 62856617
Rectal haemorrhage 154.13 14.64 72 436601 48958 63003391
Urinary retention 153.98 14.64 15 436658 30286 63022063
Dysgeusia 152.48 14.64 65 436608 46645 63005704
Liver function test increased 150.00 14.64 532 436141 32279 63020070
Pneumonia 150.00 14.64 2225 434448 454542 62597807
Hypervolaemia 149.98 14.64 12 436661 28401 63023948
Injection site pain 149.61 14.64 429 436244 129371 62922978
Full blood count decreased 149.34 14.64 7 436666 26017 63026332
Skin ulcer 148.04 14.64 638 436035 42407 63009942
Disorientation 145.55 14.64 45 436628 39407 63012942
Blood potassium decreased 144.52 14.64 54 436619 41972 63010377
Hospitalisation 143.37 14.64 227 436446 84854 62967495
Respiratory distress 142.00 14.64 30 436643 33921 63018428
Chronic obstructive pulmonary disease 141.83 14.64 133 436540 62553 62989796
Suicidal ideation 141.75 14.64 132 436541 62289 62990060
Hypomagnesaemia 141.47 14.64 16 436657 28721 63023628
Multiple organ dysfunction syndrome 141.11 14.64 110 436563 56642 62995707
Dyskinesia 140.77 14.64 25 436648 31977 63020372
Paraesthesia 140.15 14.64 579 436094 156387 62895962
Cerebral haemorrhage 139.62 14.64 22 436651 30707 63021642
Rheumatoid lung 138.44 14.64 151 436522 3697 63048652
Erythema 137.93 14.64 680 435993 175071 62877278
Chronic kidney disease 137.64 14.64 70 436603 45328 63007021
Skin necrosis 136.85 14.64 299 436374 13651 63038698
Fatigue 136.01 14.64 7431 429242 880597 62171752
Oxygen saturation decreased 135.84 14.64 251 436422 88334 62964015
Pyrexia 135.71 14.64 2348 434325 468130 62584219
Limb deformity 135.28 14.64 152 436521 3850 63048499
Haemorrhage 135.11 14.64 132 436541 60890 62991459
Thrombosis 133.33 14.64 149 436524 64606 62987743
Melaena 132.96 14.64 24 436649 30341 63022008
Altered state of consciousness 132.22 14.64 11 436662 25219 63027130
Dyspnoea exertional 131.72 14.64 132 436541 60170 62992179
Haematochezia 131.59 14.64 105 436568 53439 62998910
Haematoma 131.58 14.64 38 436635 34782 63017567
Urinary incontinence 130.43 14.64 30 436643 31984 63020365
Heart rate increased 129.97 14.64 284 436389 93954 62958395
Blood calcium decreased 129.53 14.64 15 436658 26436 63025913
Generalised tonic-clonic seizure 129.09 14.64 22 436651 28994 63023355
Aphasia 128.47 14.64 34 436639 32966 63019383
Blood creatinine increased 127.64 14.64 257 436416 87587 62964762
Lymphocyte count decreased 126.00 14.64 27 436646 30230 63022119
Metastases to liver 124.73 14.64 10 436663 23629 63028720
Inappropriate schedule of product administration 124.71 14.64 337 436336 103628 62948721
Product quality issue 123.47 14.64 46 436627 35819 63016530
Full blood count abnormal 122.86 14.64 33 436640 31684 63020665
Musculoskeletal deformity 122.30 14.64 103 436570 1806 63050543
Pulmonary toxicity 121.83 14.64 227 436446 9228 63043121
Depressed mood 121.80 14.64 62 436611 40129 63012220
Adverse reaction 121.65 14.64 237 436436 9966 63042383
Oropharyngeal pain 121.24 14.64 296 436377 94191 62958158
Drug reaction with eosinophilia and systemic symptoms 120.58 14.64 41 436632 33795 63018554
Dysuria 120.02 14.64 41 436632 33697 63018652
Night sweats 119.93 14.64 657 436016 48157 63004192
Abnormal behaviour 119.06 14.64 7 436666 21419 63030930
Drug level increased 118.90 14.64 10 436663 22726 63029623
Sciatica 118.22 14.64 509 436164 33815 63018534
Intentional product use issue 117.35 14.64 1371 435302 126521 62925828
Presyncope 117.34 14.64 24 436649 27761 63024588
Incorrect dose administered 114.91 14.64 146 436527 59822 62992527
Cardiac disorder 114.74 14.64 108 436565 50708 63001641
Irritability 113.65 14.64 38 436635 31656 63020693
Ejection fraction decreased 113.62 14.64 11 436662 22321 63030028
Vertigo 113.52 14.64 147 436526 59740 62992609
Aggression 113.40 14.64 14 436659 23484 63028865
Nodule 113.00 14.64 360 436313 20666 63031683
Colitis 112.11 14.64 101 436572 48427 63003922
Abdominal distension 111.39 14.64 271 436402 86344 62966005
Device dislocation 111.09 14.64 21 436652 25684 63026665
Acute respiratory failure 110.95 14.64 49 436624 34436 63017913
Sleep disorder 108.95 14.64 945 435728 80621 62971728
Therapy interrupted 107.81 14.64 44 436629 32411 63019938
Flatulence 107.48 14.64 52 436621 34650 63017699
Muscle spasticity 107.12 14.64 362 436311 21432 63030917
Psychotic disorder 106.96 14.64 23 436650 25689 63026660
Joint destruction 106.70 14.64 170 436503 6082 63046267
Metastases to bone 105.25 14.64 11 436662 21008 63031341
Accidental overdose 105.19 14.64 17 436656 23292 63029057
Foetal exposure during pregnancy 105.09 14.64 44 436629 31918 63020431
Ear pain 104.62 14.64 509 436164 35609 63016740
Right ventricular failure 104.21 14.64 3 436670 17185 63035164
Pulmonary hypertension 104.21 14.64 63 436610 37060 63015289
Ventricular tachycardia 103.90 14.64 9 436664 19970 63032379
Foot operation 103.87 14.64 182 436491 7049 63045300
Rash erythematous 103.66 14.64 84 436589 42426 63009923
Hallucination, visual 102.28 14.64 8 436665 19290 63033059
Pancreatitis acute 102.00 14.64 30 436643 27136 63025213
Joint effusion 101.83 14.64 303 436370 16757 63035592
Withdrawal syndrome 101.34 14.64 10 436663 19987 63032362
Arrhythmia 101.22 14.64 69 436604 38071 63014278
Mucosal inflammation 101.04 14.64 104 436569 46824 63005525
Sleep apnoea syndrome 100.90 14.64 37 436636 29096 63023253
Blood urea increased 99.29 14.64 29 436644 26350 63025999
Neutropenic sepsis 99.19 14.64 3 436670 16435 63035914
Pallor 99.03 14.64 43 436630 30525 63021824
Toxic epidermal necrolysis 98.81 14.64 26 436647 25308 63027041
Impaired work ability 98.32 14.64 304 436369 17171 63035178
Musculoskeletal pain 97.83 14.64 1018 435655 91259 62961090
Clostridium difficile colitis 97.46 14.64 13 436660 20556 63031793
Abdominal pain lower 97.07 14.64 28 436645 25650 63026699
Red blood cell sedimentation rate 96.97 14.64 142 436531 4712 63047637
Therapy cessation 96.85 14.64 44 436629 30413 63021936
Circulatory collapse 96.79 14.64 17 436656 21921 63030428
Drug ineffective for unapproved indication 96.75 14.64 57 436616 34006 63018343
Burning sensation 96.63 14.64 140 436533 54267 62998082
Sinus tachycardia 96.39 14.64 24 436649 24244 63028105
Dementia 96.30 14.64 9 436664 18785 63033564
Shoulder arthroplasty 96.26 14.64 128 436545 3874 63048475
Neurotoxicity 96.11 14.64 5 436668 16985 63035364
Weight decreased 96.07 14.64 1333 435340 275465 62776884
Tinnitus 95.16 14.64 64 436609 35564 63016785
Blood creatine phosphokinase increased 95.16 14.64 45 436628 30385 63021964
Vaginal haemorrhage 95.05 14.64 35 436638 27452 63024897
Pericardial effusion 94.69 14.64 44 436629 30014 63022335
Myocardial infarction 94.51 14.64 360 436313 99533 62952816
Cholelithiasis 93.83 14.64 98 436575 43827 63008522
Angioedema 93.76 14.64 115 436558 47850 63004499
Abortion spontaneous 93.48 14.64 112 436561 47083 63005266
Tuberculin test positive 93.36 14.64 118 436555 3393 63048956
Oral mucosal exfoliation 93.33 14.64 83 436590 1571 63050778
Gastrointestinal pain 93.03 14.64 207 436466 9569 63042780
Enthesopathy 93.02 14.64 192 436481 8422 63043927
Transient ischaemic attack 92.81 14.64 74 436599 37679 63014670
Inappropriate antidiuretic hormone secretion 92.66 14.64 3 436670 15459 63036890
Blood bilirubin increased 92.31 14.64 72 436601 37068 63015281
Bone marrow failure 92.08 14.64 43 436630 29247 63023102
Upper gastrointestinal haemorrhage 91.54 14.64 11 436662 18841 63033508
Product administration error 91.22 14.64 21 436652 22376 63029973
Pollakiuria 90.98 14.64 39 436634 27898 63024451
Body temperature increased 90.97 14.64 500 436173 36692 63015657
Blood sodium decreased 90.66 14.64 27 436646 24225 63028124
Haemoptysis 90.57 14.64 42 436631 28684 63023665
X-ray abnormal 90.22 14.64 183 436490 7927 63044422
Lip swelling 89.62 14.64 51 436622 31012 63021337
Septic shock 89.24 14.64 204 436469 66425 62985924
Ankylosing spondylitis 88.89 14.64 212 436461 10262 63042087
Physical disability 88.86 14.64 102 436571 2646 63049703
Acute myocardial infarction 88.11 14.64 56 436617 32068 63020281
Diabetic ketoacidosis 88.08 14.64 17 436656 20488 63031861
Muscle twitching 87.30 14.64 15 436658 19653 63032696
Haematuria 86.84 14.64 46 436627 29111 63023238
Cholestasis 86.84 14.64 47 436626 29387 63022962
Skin exfoliation 86.74 14.64 101 436572 43001 63009348
Product prescribing error 86.74 14.64 36 436637 26253 63026096
Memory impairment 86.66 14.64 395 436278 103863 62948486
Swelling face 85.29 14.64 194 436479 63281 62989068
Ulcer 85.23 14.64 381 436292 25726 63026623
Feeling hot 85.14 14.64 134 436539 50220 63002129
Hepatic function abnormal 84.96 14.64 78 436595 37064 63015285
Face oedema 84.24 14.64 18 436655 20194 63032155
Retinal toxicity 84.18 14.64 70 436603 1205 63051144
Joint laxity 83.99 14.64 94 436579 2370 63049979
Arthrodesis 83.96 14.64 100 436573 2701 63049648
Renal impairment 83.85 14.64 318 436355 88037 62964312
Cellulitis 83.73 14.64 286 436387 81672 62970677
Head injury 83.41 14.64 42 436631 27354 63024995
Hypocalcaemia 83.32 14.64 58 436615 31655 63020694
Sinus bradycardia 83.21 14.64 4 436669 14547 63037802
Creatinine renal clearance decreased 83.05 14.64 8 436665 16300 63036049
Myoclonus 82.92 14.64 7 436666 15861 63036488
Hepatotoxicity 82.72 14.64 486 436187 36555 63015794
Leukocytosis 81.64 14.64 38 436635 25897 63026452
Infusion site pain 81.53 14.64 10 436663 16859 63035490
Panic attack 81.43 14.64 26 436647 22305 63030044
Drug eruption 81.41 14.64 402 436271 28292 63024057
Product substitution issue 81.06 14.64 8 436665 15988 63036361
Macular degeneration 81.04 14.64 33 436640 24343 63028006
Device issue 81.02 14.64 31 436642 23750 63028599
Acute myeloid leukaemia 80.85 14.64 11 436662 17136 63035213
Lacrimation increased 80.79 14.64 21 436652 20610 63031739
Paraesthesia oral 80.56 14.64 17 436656 19239 63033110
Rheumatoid factor negative 80.51 14.64 51 436622 560 63051789
Hemiparesis 79.91 14.64 30 436643 23252 63029097
Blood pressure increased 79.28 14.64 722 435951 161340 62891009
Status epilepticus 78.84 14.64 7 436666 15226 63037123
Pruritus allergic 78.75 14.64 74 436599 1508 63050841
Mental disorder 78.51 14.64 40 436633 25879 63026470
Cerebral infarction 78.38 14.64 33 436640 23860 63028489
Dysphonia 78.35 14.64 129 436544 47485 63004864
Electrolyte imbalance 77.55 14.64 21 436652 20055 63032294
Disseminated intravascular coagulation 77.32 14.64 18 436655 19033 63033316
Emotional distress 77.29 14.64 66 436607 32483 63019866
Epilepsy 77.28 14.64 45 436628 27020 63025329
Respiratory disorder 76.71 14.64 496 436177 38586 63013763
Spinal column injury 76.44 14.64 82 436591 1969 63050380
Stevens-Johnson syndrome 76.34 14.64 38 436635 24912 63027437
Transfusion 76.10 14.64 8 436665 15209 63037140
General physical health deterioration 75.73 14.64 1867 434806 199535 62852814
Eye pain 75.20 14.64 73 436600 33781 63018568
Small intestinal obstruction 75.07 14.64 17 436656 18320 63034029
Coordination abnormal 75.03 14.64 5 436668 13768 63038581
Accidental exposure to product 74.86 14.64 48 436625 27357 63024992
Poisoning 74.56 14.64 5 436668 13695 63038654
Surgical failure 74.32 14.64 58 436615 908 63051441
Obstructive airways disorder 73.89 14.64 25 436648 20674 63031675
Bacteraemia 73.23 14.64 15 436658 17333 63035016
Agranulocytosis 72.89 14.64 41 436632 25093 63027256
Labelled drug-drug interaction medication error 72.60 14.64 5 436668 13394 63038955
Dystonia 72.48 14.64 6 436667 13813 63038536
Intestinal obstruction 71.74 14.64 64 436609 30835 63021514
Pain in jaw 71.42 14.64 118 436555 43378 63008971
Dislocation of vertebra 71.37 14.64 173 436500 8462 63043887
Loss of consciousness 71.30 14.64 497 436176 117624 62934725
Renal disorder 69.94 14.64 74 436599 32900 63019449
Diplopia 69.84 14.64 38 436635 23690 63028659
Pulmonary arterial hypertension 69.66 14.64 34 436639 22543 63029806
Seronegative arthritis 69.43 14.64 109 436564 3850 63048499
Joint injury 69.29 14.64 393 436280 29179 63023170
Hot flush 69.02 14.64 156 436517 51003 63001346
Mania 68.84 14.64 4 436669 12363 63039986
Wrist deformity 68.77 14.64 79 436594 2051 63050298
Device difficult to use 68.68 14.64 5 436668 12791 63039558
Swollen tongue 68.48 14.64 83 436590 34717 63017632
Hypothermia 68.28 14.64 7 436666 13574 63038775
Speech disorder 67.86 14.64 109 436564 40520 63011829
Tuberculosis 67.75 14.64 200 436473 11011 63041338
Eosinophilia 67.62 14.64 36 436637 22720 63029629
Skin discolouration 67.50 14.64 97 436576 37731 63014618
Paranoia 67.47 14.64 3 436670 11676 63040673
Red cell distribution width decreased 67.37 14.64 77 436596 1988 63050361
Haemorrhage intracranial 67.25 14.64 7 436666 13412 63038937
Incontinence 67.16 14.64 3 436670 11629 63040720
Exostosis 67.07 14.64 272 436401 17590 63034759
Blood glucose decreased 67.04 14.64 30 436643 20922 63031427
Bone swelling 67.03 14.64 70 436603 1628 63050721
Complication associated with device 67.03 14.64 17 436656 16961 63035388
Tachypnoea 67.02 14.64 18 436655 17284 63035065
Cardiogenic shock 66.96 14.64 20 436653 17912 63034437
Systemic lupus erythematosus rash 66.85 14.64 80 436593 2172 63050177
Adjustment disorder with depressed mood 66.46 14.64 187 436486 10017 63042332
Breast cancer stage III 66.34 14.64 189 436484 10197 63042152
Frequent bowel movements 66.13 14.64 38 436635 22984 63029365
Pancreatitis 65.84 14.64 150 436523 48905 63003444
Vascular access complication 65.78 14.64 77 436596 2041 63050308
Loose body in joint 65.64 14.64 61 436612 1225 63051124
Basal cell carcinoma 65.59 14.64 372 436301 27619 63024730
Metastases to central nervous system 65.26 14.64 7 436666 13098 63039251
Anuria 64.33 14.64 6 436667 12545 63039804
Visual acuity reduced 64.17 14.64 35 436638 21791 63030558
Joint dislocation 64.13 14.64 278 436395 18522 63033827
Premature labour 64.03 14.64 6 436667 12498 63039851
Diabetes mellitus inadequate control 64.01 14.64 13 436660 15113 63037236
Eye swelling 63.83 14.64 43 436630 23875 63028474
Ischaemic stroke 63.56 14.64 22 436651 17935 63034414
Subdural haematoma 63.44 14.64 11 436662 14317 63038032
Metastases to lung 63.01 14.64 7 436666 12743 63039606
Malnutrition 62.99 14.64 14 436659 15284 63037065
Nervousness 62.98 14.64 72 436601 30907 63021442
Product use in unapproved indication 62.93 14.64 860 435813 178220 62874129
Clostridium difficile infection 62.52 14.64 68 436605 29854 63022495
Influenza 61.96 14.64 465 436208 108257 62944092
Respiratory depression 61.90 14.64 10 436663 13705 63038644
Fear 61.83 14.64 16 436657 15750 63036599
Mitral valve incompetence 61.23 14.64 29 436644 19565 63032784
Nasal congestion 61.21 14.64 238 436435 65422 62986927
Blood magnesium decreased 60.98 14.64 9 436664 13189 63039160
Peritonitis 60.75 14.64 21 436652 17133 63035216
Muscular weakness 60.74 14.64 543 436130 121810 62930539
Left ventricular dysfunction 60.74 14.64 6 436667 11982 63040367
Nightmare 60.61 14.64 28 436645 19166 63033183
Incorrect product administration duration 60.59 14.64 5 436668 11541 63040808
Mydriasis 60.53 14.64 6 436667 11950 63040399
Viral infection 60.20 14.64 95 436578 35568 63016781
Hepatic failure 60.17 14.64 95 436578 35561 63016788
Ankle arthroplasty 59.82 14.64 68 436605 1745 63050604
Therapeutic response unexpected 59.80 14.64 27 436646 18732 63033617
Cyanosis 59.51 14.64 21 436652 16914 63035435
Haematemesis 59.35 14.64 73 436600 30339 63022010
Extrapyramidal disorder 59.25 14.64 10 436663 13274 63039075
Mean platelet volume decreased 59.09 14.64 82 436591 2587 63049762
Infusion site erythema 58.77 14.64 6 436667 11673 63040676
Cholecystitis chronic 58.76 14.64 3 436670 10358 63041991
Gastritis 58.68 14.64 104 436569 37199 63015150
No adverse event 58.55 14.64 123 436550 41282 63011067
Premature baby 58.46 14.64 35 436638 20700 63031649
Caesarean section 58.36 14.64 22 436651 17010 63035339
Myopathy 58.31 14.64 5 436668 11186 63041163
International normalised ratio fluctuation 57.68 14.64 78 436595 2400 63049949
Emotional disorder 57.66 14.64 11 436662 13368 63038981
Ileus 57.64 14.64 15 436658 14710 63037639
Muscle rigidity 57.63 14.64 6 436667 11494 63040855
Demyelination 57.58 14.64 139 436534 6781 63045568
Productive cough 57.09 14.64 232 436441 62976 62989373
Retinitis 56.50 14.64 129 436544 6067 63046282
Shock 56.41 14.64 47 436626 23416 63028933
Aspiration 56.12 14.64 5 436668 10846 63041503
Hypercholesterolaemia 55.69 14.64 292 436381 21042 63031307
Mean cell volume decreased 55.68 14.64 99 436574 3879 63048470
Cytomegalovirus infection 55.47 14.64 38 436635 20914 63031435
Hypophosphataemia 54.67 14.64 7 436666 11419 63040930
Hypersomnia 54.49 14.64 28 436645 18027 63034322
Anti-cyclic citrullinated peptide antibody 54.37 14.64 134 436539 6624 63045725
Investigation abnormal 53.97 14.64 67 436606 1891 63050458
Hyperbilirubinaemia 53.96 14.64 7 436666 11307 63041042
Device related infection 53.65 14.64 49 436624 23343 63029006
Procedural pain 53.36 14.64 42 436631 21527 63030822
Tricuspid valve incompetence 53.35 14.64 17 436656 14604 63037745
Supraventricular tachycardia 53.14 14.64 16 436657 14255 63038094
Ataxia 53.13 14.64 19 436654 15176 63037173
Blindness 52.75 14.64 43 436630 21656 63030693
Multiple fractures 52.32 14.64 154 436519 8464 63043885
Blood calcium increased 52.12 14.64 3 436670 9347 63043002
Infusion site swelling 51.92 14.64 4 436669 9766 63042583
Myelosuppression 51.62 14.64 52 436621 23651 63028698
Dermatitis atopic 51.62 14.64 4 436669 9720 63042629
Hepatic encephalopathy 51.43 14.64 8 436665 11274 63041075
Gait disturbance 51.43 14.64 1636 435037 181542 62870807
Product label confusion 51.27 14.64 63 436610 1759 63050590
Acidosis 51.12 14.64 8 436665 11225 63041124
Anal incontinence 50.95 14.64 15 436658 13561 63038788
Gastric disorder 50.95 14.64 435 436238 36934 63015415
Back injury 50.64 14.64 164 436509 9496 63042853
Ventricular fibrillation 50.63 14.64 10 436663 11857 63040492
Ocular hyperaemia 50.51 14.64 59 436614 25085 63027264
Multiple sclerosis 50.25 14.64 56 436617 24316 63028033
Colitis ischaemic 50.18 14.64 7 436666 10701 63041648
Retching 50.04 14.64 19 436654 14626 63037723
Stress cardiomyopathy 49.85 14.64 4 436669 9446 63042903
Tumour lysis syndrome 49.76 14.64 3 436670 8987 63043362
Hip fracture 49.29 14.64 79 436594 29395 63022954
Bloody discharge 49.19 14.64 57 436616 1494 63050855
Mental impairment 48.96 14.64 18 436655 14133 63038216
Tubulointerstitial nephritis 48.93 14.64 39 436634 19864 63032485
Toxic skin eruption 48.79 14.64 14 436659 12871 63039478
Infusion site reaction 48.59 14.64 88 436585 3499 63048850
Onychomycosis 48.40 14.64 142 436531 7790 63044559
Synovial cyst 48.40 14.64 170 436503 10263 63042086
Jaundice 48.36 14.64 79 436594 29172 63023177
Electrocardiogram abnormal 48.10 14.64 4 436669 9175 63043174
Aplastic anaemia 47.93 14.64 5 436668 9564 63042785
Rash macular 47.82 14.64 54 436619 23310 63029039
Haemorrhoids 47.78 14.64 49 436624 22101 63030248
Urine output decreased 47.64 14.64 10 436663 11360 63040989
Bronchitis 47.54 14.64 590 436083 124345 62928004
Acute respiratory distress syndrome 47.51 14.64 55 436618 23479 63028870
Sensitivity to weather change 47.50 14.64 133 436540 7104 63045245
Cystitis 47.09 14.64 206 436467 54785 62997564
Hypothyroidism 46.85 14.64 144 436529 42488 63009861
Coronary artery disease 46.78 14.64 95 436578 32282 63020067
Abnormal dreams 46.72 14.64 8 436665 10508 63041841
Contusion 46.64 14.64 1357 435316 148687 62903662
Cardiomegaly 46.56 14.64 32 436641 17582 63034767
Upper respiratory tract infection 46.23 14.64 352 436321 81695 62970654
Lymphopenia 46.21 14.64 35 436638 18292 63034057
Delusion 45.61 14.64 13 436660 12004 63040345
Ventricular extrasystoles 45.57 14.64 12 436661 11675 63040674
Injection site mass 45.31 14.64 37 436636 18619 63033730
Central nervous system lesion 45.29 14.64 9 436664 10626 63041723
Impaired quality of life 45.27 14.64 19 436654 13764 63038585
Throat tightness 45.21 14.64 63 436610 24824 63027525
Atrioventricular block complete 44.93 14.64 3 436670 8248 63044101
Hepatic cytolysis 44.87 14.64 25 436648 15382 63036967
Head discomfort 44.86 14.64 18 436655 13397 63038952
Renal tubular necrosis 44.81 14.64 13 436660 11865 63040484
Sinus disorder 44.76 14.64 62 436611 24491 63027858
Malaise 44.66 14.64 2372 434301 413582 62638767
Angina pectoris 44.53 14.64 87 436586 29991 63022358
Troponin increased 44.31 14.64 8 436665 10113 63042236
Mycotic allergy 44.17 14.64 44 436629 966 63051383
Acute generalised exanthematous pustulosis 44.03 14.64 11 436662 11088 63041261
Breast cancer metastatic 43.81 14.64 14 436659 12004 63040345
Tardive dyskinesia 43.75 14.64 4 436669 8498 63043851
Wrist surgery 43.69 14.64 41 436632 834 63051515
Thirst 43.54 14.64 21 436652 14020 63038329
Restless legs syndrome 43.48 14.64 38 436635 18493 63033856
Seasonal allergy 43.34 14.64 48 436625 20902 63031447
Muscle tightness 43.13 14.64 14 436659 11886 63040463
Bone density abnormal 43.05 14.64 81 436592 3317 63049032
Apathy 43.02 14.64 5 436668 8789 63043560
Throat irritation 42.92 14.64 125 436548 37522 63014827
Sensory loss 42.91 14.64 9 436664 10229 63042120
Pre-eclampsia 42.73 14.64 6 436667 9127 63043222
Hyperlipidaemia 42.55 14.64 43 436630 19528 63032821
Hepatocellular injury 42.47 14.64 77 436596 27304 63025045
Therapy non-responder 42.41 14.64 746 435927 75155 62977194
Renal injury 42.33 14.64 7 436666 9432 63042917
Faeces discoloured 42.18 14.64 39 436634 18470 63033879
Food allergy 42.06 14.64 13 436660 11388 63040961
Back pain 42.02 14.64 1441 435232 262704 62789645
Illness 41.87 14.64 184 436489 48875 63003474
Hypotonia 41.39 14.64 7 436666 9278 63043071
Brain oedema 41.39 14.64 23 436650 14172 63038177
Oesophagitis 41.38 14.64 26 436647 14982 63037367
Influenza like illness 41.38 14.64 279 436394 66545 62985804
Headache 41.34 14.64 3772 432901 629469 62422880
Fine motor skill dysfunction 41.31 14.64 98 436575 4727 63047622
Eosinophil count increased 41.15 14.64 12 436661 10916 63041433
Device breakage 41.10 14.64 14 436659 11528 63040821
Pharyngitis 40.98 14.64 258 436415 19885 63032464
Amenorrhoea 40.97 14.64 9 436664 9905 63042444
Feeling cold 40.92 14.64 63 436610 23825 63028524
Injection site erythema 40.88 14.64 370 436303 82804 62969545
Shock haemorrhagic 40.85 14.64 9 436664 9886 63042463
Respiratory tract infection 40.85 14.64 147 436526 41336 63011013
Haemodynamic instability 40.81 14.64 7 436666 9183 63043166
Transaminases abnormal 40.75 14.64 35 436638 631 63051718
Rhinitis allergic 40.43 14.64 15 436658 11712 63040637
Oliguria 40.26 14.64 7 436666 9094 63043255
Urticarial vasculitis 40.17 14.64 35 436638 644 63051705
Prescribed overdose 40.15 14.64 385 436288 33768 63018581
Bronchitis chronic 40.11 14.64 91 436582 4262 63048087
Lower gastrointestinal haemorrhage 39.84 14.64 4 436669 7886 63044463
Dermatitis contact 39.81 14.64 13 436660 10995 63041354
Myelodysplastic syndrome 39.74 14.64 34 436639 16720 63035629
Anticipatory anxiety 39.72 14.64 46 436627 1205 63051144
Wheezing 39.62 14.64 443 436230 95152 62957197
Chromaturia 39.56 14.64 34 436639 16683 63035666
Ovarian cyst 39.51 14.64 31 436642 15914 63036435
Coagulopathy 39.37 14.64 50 436623 20494 63031855
Dactylitis 39.16 14.64 67 436606 2545 63049804
Osteonecrosis of jaw 39.05 14.64 118 436555 35005 63017344
Lupus-like syndrome 39.00 14.64 208 436465 15087 63037262
Glomerular filtration rate decreased 38.87 14.64 22 436651 13419 63038930
Fear of injection 38.80 14.64 123 436550 7041 63045308
Atrioventricular block first degree 38.58 14.64 3 436670 7270 63045079
Hepatitis 38.46 14.64 431 436242 39357 63012992
Atelectasis 38.42 14.64 55 436618 21428 63030921
Pneumonia viral 38.41 14.64 131 436542 7791 63044558
Neuralgia 38.37 14.64 75 436598 25851 63026498
Hyperthyroidism 38.33 14.64 27 436646 14646 63037703
Atrioventricular block 38.29 14.64 4 436669 7643 63044706
Gestational diabetes 38.16 14.64 6 436667 8390 63043959
Joint arthroplasty 38.09 14.64 68 436605 2673 63049676
Neck deformity 38.03 14.64 59 436614 2062 63050287
Cholecystitis 37.97 14.64 30 436643 15347 63037002
Posterior reversible encephalopathy syndrome 37.83 14.64 38 436635 17307 63035042
Normal newborn 37.83 14.64 6 436667 8335 63044014
Eructation 37.78 14.64 6 436667 8327 63044022
Polyarthritis 37.69 14.64 154 436519 9992 63042357
Blood loss anaemia 37.54 14.64 8 436665 8993 63043356
White blood cell count increased 37.41 14.64 189 436484 48372 63003977
Hypoacusis 37.39 14.64 68 436605 24083 63028266
Mood altered 37.38 14.64 28 436645 14715 63037634
Haemodialysis 37.22 14.64 8 436665 8939 63043410
Extremity contracture 37.08 14.64 45 436628 1240 63051109
Device malfunction 36.84 14.64 41 436632 17816 63034533
Eyelid oedema 36.81 14.64 13 436660 10466 63041883
Ovarian neoplasm 36.69 14.64 38 436635 875 63051474
Prescribed underdose 36.56 14.64 338 436335 29351 63022998
Infusion site extravasation 36.51 14.64 13 436660 10413 63041936
Deep vein thrombosis postoperative 36.42 14.64 165 436508 11204 63041145
Subarachnoid haemorrhage 36.37 14.64 27 436646 14256 63038093
Pemphigoid 36.37 14.64 4 436669 7340 63045009
Femur fracture 36.22 14.64 443 436230 41313 63011036
Breast cancer stage I 36.11 14.64 3 436670 6886 63045463
Epstein-Barr virus infection 36.04 14.64 6 436667 8044 63044305
Underdose 36.00 14.64 85 436588 27371 63024978
Chronic sinusitis 35.76 14.64 22 436651 12821 63039528
Hair follicle tumour benign 35.61 14.64 27 436646 404 63051945
Ear infection 35.61 14.64 411 436262 37802 63014547
Mouth ulceration 35.46 14.64 365 436308 32619 63019730
Heavy menstrual bleeding 35.38 14.64 42 436631 17731 63034618
Bedridden 35.11 14.64 160 436513 10891 63041458
Skin laceration 35.10 14.64 64 436609 22644 63029705
Peripheral coldness 35.05 14.64 20 436653 12145 63040204
Injection site swelling 35.04 14.64 188 436485 47384 63004965
Soft tissue disorder 34.86 14.64 87 436586 4335 63048014
End stage renal disease 34.84 14.64 3 436670 6690 63045659
Colitis ulcerative 34.83 14.64 80 436593 26011 63026338
Thyroid neoplasm 34.81 14.64 82 436591 3937 63048412
Mean cell haemoglobin decreased 34.80 14.64 96 436577 5083 63047266
Musculoskeletal chest pain 34.79 14.64 57 436616 21026 63031323
Rhinorrhoea 34.78 14.64 286 436387 65291 62987058
Cutaneous vasculitis 34.75 14.64 97 436576 5172 63047177
Blood lactic acid increased 34.74 14.64 4 436669 7082 63045267
Rib fracture 34.65 14.64 64 436609 22533 63029816
Nocturia 34.44 14.64 7 436666 8134 63044215
Myocarditis 34.29 14.64 14 436659 10311 63042038
Allergic oedema 34.25 14.64 35 436638 793 63051556
Eye pruritus 34.18 14.64 47 436626 18624 63033725
Toxic encephalopathy 34.11 14.64 3 436670 6576 63045773
Suspected suicide 34.04 14.64 3 436670 6565 63045784
Upper-airway cough syndrome 34.02 14.64 18 436655 11400 63040949
Lymphoedema 34.01 14.64 19 436654 11673 63040676
Joint space narrowing 33.99 14.64 30 436643 562 63051787
Immune thrombocytopenia 33.95 14.64 15 436658 10541 63041808
Atrial septal defect 33.81 14.64 4 436669 6934 63045415
Vascular device infection 33.75 14.64 5 436668 7307 63045042
Lung neoplasm malignant 33.42 14.64 52 436621 19581 63032768
Pustular psoriasis 33.35 14.64 88 436585 4538 63047811
Delirium 33.34 14.64 207 436466 50334 63002015
Acute coronary syndrome 33.19 14.64 14 436659 10112 63042237
Walking aid user 33.19 14.64 154 436519 10563 63041786
Haemolytic anaemia 33.18 14.64 14 436659 10111 63042238
Hypoalbuminaemia 33.18 14.64 20 436653 11785 63040564
Drug level decreased 33.11 14.64 7 436666 7912 63044437
Hereditary angioedema 33.06 14.64 6 436667 7556 63044793
Failure to thrive 33.05 14.64 5 436668 7193 63045156
Generalised oedema 32.99 14.64 36 436637 15782 63036567
Thinking abnormal 32.88 14.64 16 436657 10627 63041722
Atrial flutter 32.86 14.64 13 436660 9759 63042590
Mycobacterium tuberculosis complex test positive 32.78 14.64 57 436616 2194 63050155
Hypoaesthesia oral 32.72 14.64 25 436648 13008 63039341
Hypermobility syndrome 32.62 14.64 34 436639 789 63051560
Blood triglycerides increased 32.59 14.64 23 436650 12465 63039884
Acute pulmonary oedema 32.53 14.64 8 436665 8150 63044199
Infiltration anaesthesia 32.53 14.64 19 436654 178 63052171
Purpura 32.40 14.64 19 436654 11366 63040983
Impaired gastric emptying 32.39 14.64 149 436524 10183 63042166
Hiatus hernia 32.37 14.64 62 436611 21532 63030817
Wound infection 32.29 14.64 255 436418 21155 63031194
Unevaluable event 32.09 14.64 214 436459 51172 63001177
Increased appetite 32.07 14.64 13 436660 9617 63042732
Hemiplegia 32.02 14.64 12 436661 9311 63043038
Neutrophil count increased 31.90 14.64 40 436633 16487 63035862
Migraine 31.87 14.64 509 436164 102837 62949512
Menstruation irregular 31.85 14.64 5 436668 6999 63045350
Nystagmus 31.81 14.64 3 436670 6217 63046132
Lymphadenopathy 31.76 14.64 146 436527 38312 63014037
Dialysis 31.72 14.64 16 436657 10411 63041938
Bradyphrenia 31.70 14.64 5 436668 6975 63045374
Personality change 31.66 14.64 5 436668 6968 63045381
Unintended pregnancy 31.55 14.64 3 436670 6176 63046173
Rash papular 31.37 14.64 37 436636 15665 63036684
Escherichia infection 31.34 14.64 25 436648 12729 63039620
Skin papilloma 31.33 14.64 90 436583 4879 63047470
Nephropathy toxic 31.24 14.64 13 436660 9466 63042883
Drug tolerance 31.18 14.64 112 436561 6837 63045512
Progressive multifocal leukoencephalopathy 31.16 14.64 26 436647 12945 63039404
Labile blood pressure 31.02 14.64 49 436624 1740 63050609
Lower limb fracture 30.96 14.64 278 436395 23943 63028406
Female genital tract fistula 30.96 14.64 7 436666 7552 63044797
Sensory disturbance 30.93 14.64 29 436644 13643 63038706
Foetal growth restriction 30.92 14.64 7 436666 7546 63044803
Taste disorder 30.88 14.64 29 436644 13633 63038716
Alanine aminotransferase abnormal 30.77 14.64 84 436589 4420 63047929
Pulmonary haemorrhage 30.75 14.64 6 436667 7175 63045174
Skin reaction 30.71 14.64 191 436482 14658 63037691
Nasal polyps 30.65 14.64 3 436670 6036 63046313
Heart rate irregular 30.54 14.64 68 436605 22353 63029996
Spinal compression fracture 30.35 14.64 32 436641 14251 63038098
Pulmonary mass 30.26 14.64 262 436411 22334 63030015
Weight increased 30.20 14.64 2132 434541 258660 62793689
Cerebral ischaemia 30.15 14.64 5 436668 6723 63045626
Prothrombin time prolonged 30.12 14.64 14 436659 9550 63042799
Ageusia 30.03 14.64 30 436643 13698 63038651
Needle issue 29.98 14.64 17 436656 10359 63041990
Vasculitic rash 29.86 14.64 42 436631 1342 63051007
Jaundice cholestatic 29.56 14.64 7 436666 7317 63045032
Facet joint syndrome 29.55 14.64 163 436510 11975 63040374
Cardiomyopathy 29.53 14.64 47 436626 17537 63034812
Bipolar disorder 29.50 14.64 9 436664 7951 63044398
Pre-existing condition improved 29.35 14.64 10 436663 8234 63044115
Staphylococcal infection 29.31 14.64 165 436508 41091 63011258
Haematocrit decreased 29.24 14.64 155 436518 39185 63013164
Poor quality sleep 29.22 14.64 58 436615 19877 63032472
Bacterial infection 29.21 14.64 56 436617 19443 63032906
Cold sweat 29.12 14.64 24 436649 12023 63040326
Product storage error 29.08 14.64 36 436637 14920 63037429
Gastroenteritis viral 29.02 14.64 76 436597 23624 63028725
Disease susceptibility 29.01 14.64 18 436655 190 63052159
Secretion discharge 28.95 14.64 163 436510 12068 63040281
Hepatitis cholestatic 28.92 14.64 6 436667 6872 63045477
Interstitial lung disease 28.92 14.64 592 436081 61316 62991033
Enterocolitis 28.92 14.64 9 436664 7849 63044500
Mass excision 28.75 14.64 22 436651 334 63052015
Psychomotor hyperactivity 28.68 14.64 19 436654 10644 63041705
Sneezing 28.46 14.64 51 436622 18167 63034182
Flank pain 28.38 14.64 43 436630 16367 63035982
Granulocytopenia 28.32 14.64 3 436670 5669 63046680
Injection site haemorrhage 28.25 14.64 80 436593 24234 63028115
Live birth 28.21 14.64 285 436388 25345 63027004
Angina unstable 28.21 14.64 7 436666 7088 63045261
Apnoea 28.10 14.64 10 436663 8012 63044337
Acute hepatic failure 28.02 14.64 52 436621 18275 63034074
Brain injury 27.90 14.64 7 436666 7036 63045313
Extra dose administered 27.84 14.64 5 436668 6345 63046004
Spinal stenosis 27.82 14.64 187 436486 14738 63037611
Immobile 27.71 14.64 97 436576 5846 63046503
Drug-induced liver injury 27.58 14.64 409 436264 39813 63012536
Acne 27.54 14.64 76 436597 23217 63029132
Lipase increased 27.51 14.64 17 436656 9883 63042466
Hypercalcaemia 27.46 14.64 307 436366 28015 63024334
Eyelid ptosis 27.33 14.64 8 436665 7259 63045090
Fistula 27.31 14.64 19 436654 10374 63041975
Glycosylated haemoglobin increased 27.23 14.64 27 436646 12371 63039978
Lupus vulgaris 27.23 14.64 97 436576 5897 63046452
Exercise tolerance decreased 27.21 14.64 3 436670 5494 63046855
Myocardial ischaemia 27.11 14.64 29 436644 12830 63039519
Exposure during pregnancy 27.06 14.64 1319 435354 154228 62898121
Arteriosclerosis coronary artery 26.77 14.64 12 436661 8361 63043988
Functional gastrointestinal disorder 26.71 14.64 77 436596 4182 63048167
Gait inability 26.60 14.64 512 436161 52447 62999902
Insurance issue 26.45 14.64 5 436668 6116 63046233
Hyperventilation 26.42 14.64 5 436668 6111 63046238
Blood pressure systolic decreased 26.29 14.64 9 436664 7388 63044961
Klebsiella infection 26.27 14.64 13 436660 8553 63043796
Dry throat 26.27 14.64 7 436666 6758 63045591
Drug resistance 26.25 14.64 76 436597 22857 63029492
Erythema multiforme 26.18 14.64 19 436654 10150 63042199
Hepatic enzyme abnormal 26.15 14.64 100 436573 6292 63046057
Proteinuria 26.13 14.64 58 436615 19087 63033262
Wrist fracture 26.10 14.64 33 436640 13554 63038795
Salivary hypersecretion 26.10 14.64 10 436663 7656 63044693
Menstrual disorder 26.04 14.64 3 436670 5310 63047039
Intermenstrual bleeding 25.91 14.64 11 436662 7915 63044434
Oligohydramnios 25.86 14.64 6 436667 6360 63045989
Bone disorder 25.86 14.64 242 436431 21084 63031265
Metastases to lymph nodes 25.60 14.64 12 436661 8146 63044203
Concussion 25.51 14.64 16 436657 9228 63043121
Intracranial pressure increased 25.50 14.64 3 436670 5224 63047125
Skin irritation 25.34 14.64 18 436655 9723 63042626
Motor dysfunction 25.33 14.64 22 436651 10739 63041610
Metastasis 25.31 14.64 3 436670 5194 63047155
Anger 25.26 14.64 29 436644 12427 63039922
Eczema 25.26 14.64 125 436548 32166 63020183
Mean cell haemoglobin concentration abnormal 25.21 14.64 14 436659 118 63052231
Allergy to chemicals 25.20 14.64 61 436612 2981 63049368
Injection site reaction 25.19 14.64 553 436120 57971 62994378
Foetal death 25.18 14.64 23 436650 10957 63041392
Rheumatoid factor 25.16 14.64 20 436653 322 63052027
Refusal of treatment by patient 24.82 14.64 4 436669 5493 63046856
Pain of skin 24.79 14.64 26 436647 11608 63040741
Ankle deformity 24.79 14.64 23 436650 461 63051888
Enteritis 24.78 14.64 13 436660 8273 63044076
Asphyxia 24.77 14.64 6 436667 6175 63046174
Metabolic disorder 24.75 14.64 7 436666 6496 63045853
Intestinal sepsis 24.58 14.64 19 436654 293 63052056
Pneumonia fungal 24.57 14.64 4 436669 5451 63046898
Dizziness postural 24.49 14.64 10 436663 7366 63044983
Petechiae 24.43 14.64 36 436637 13861 63038488
Vitamin D deficiency 24.41 14.64 36 436637 13856 63038493
Bundle branch block left 24.39 14.64 9 436664 7050 63045299
Large intestine perforation 24.36 14.64 14 436659 8468 63043881
Lip dry 24.30 14.64 186 436487 15284 63037065
Blood albumin decreased 24.29 14.64 40 436633 14726 63037623
Respiration abnormal 24.25 14.64 7 436666 6410 63045939
Ear discomfort 24.25 14.64 12 436661 7894 63044455
Injection site hypersensitivity 24.14 14.64 48 436625 2049 63050300
Gingival pain 24.12 14.64 13 436660 8149 63044200
Localised oedema 24.09 14.64 4 436669 5374 63046975
Infusion site pruritus 23.91 14.64 6 436667 6029 63046320
Osteoporotic fracture 23.76 14.64 68 436605 3678 63048671
Rheumatic disorder 23.75 14.64 60 436613 3012 63049337
Hyperthermia 23.72 14.64 17 436656 9139 63043210
Therapy partial responder 23.65 14.64 23 436650 10635 63041714
Spinal fracture 23.61 14.64 57 436616 18214 63034135
Tumour marker increased 23.54 14.64 3 436670 4912 63047437
Systemic inflammatory response syndrome 23.44 14.64 5 436668 5616 63046733
Bowel movement irregularity 23.40 14.64 4 436669 5260 63047089
White blood cell count abnormal 23.39 14.64 95 436578 6147 63046202
Glucose tolerance impaired 23.38 14.64 8 436665 6569 63045780
Oral discomfort 23.37 14.64 125 436548 9076 63043273
Major depression 23.36 14.64 13 436660 8005 63044344
Peritonitis bacterial 23.32 14.64 3 436670 4876 63047473
Fungal infection 23.30 14.64 153 436520 36721 63015628
Hypovolaemic shock 23.23 14.64 7 436666 6234 63046115
Diabetic eye disease 23.20 14.64 14 436659 140 63052209
Arteriosclerosis 23.18 14.64 21 436652 10045 63042304
Eye movement disorder 23.18 14.64 4 436669 5224 63047125
Colitis microscopic 23.13 14.64 126 436547 9213 63043136
Heart rate decreased 23.12 14.64 201 436472 45359 63006990
Brain natriuretic peptide increased 23.08 14.64 4 436669 5209 63047140
Appendicitis 23.04 14.64 14 436659 8215 63044134
Lung infiltration 23.04 14.64 40 436633 14423 63037926
C-reactive protein 23.03 14.64 80 436593 4802 63047547
Nail disorder 23.03 14.64 161 436512 12854 63039495
Cardiac failure acute 22.99 14.64 19 436654 9504 63042845
Device leakage 22.96 14.64 10 436663 7086 63045263
Drug use disorder 22.93 14.64 81 436592 4903 63047446
Expired product administered 22.89 14.64 7 436666 6174 63046175
Hepatic fibrosis 22.88 14.64 66 436607 3586 63048763
Pelvic pain 22.83 14.64 36 436637 13483 63038866
Steatohepatitis 22.79 14.64 25 436648 616 63051733
Diastolic dysfunction 22.78 14.64 8 436665 6463 63045886
Embolism 22.78 14.64 13 436660 7893 63044456
Fracture delayed union 22.72 14.64 51 436622 2371 63049978
Product complaint 22.70 14.64 33 436640 12776 63039573
Sudden death 22.67 14.64 23 436650 10426 63041923
Splenomegaly 22.60 14.64 26 436647 11131 63041218
Scleroderma 22.49 14.64 5 436668 5457 63046892
Bronchopulmonary aspergillosis 22.41 14.64 16 436657 8619 63043730
Pneumothorax 22.41 14.64 49 436624 16212 63036137
Post procedural complication 22.27 14.64 53 436620 17021 63035328
Concomitant disease aggravated 22.22 14.64 18 436655 9094 63043255
Blood potassium increased 22.20 14.64 59 436614 18250 63034099
Micturition urgency 22.20 14.64 20 436653 9591 63042758
Polyomavirus-associated nephropathy 22.12 14.64 43 436630 1805 63050544
Hepatic ischaemia 22.07 14.64 25 436648 639 63051710
Blood alkaline phosphatase increased 22.05 14.64 189 436484 42778 63009571
Middle lobe syndrome 22.04 14.64 9 436664 34 63052315
Activated partial thromboplastin time prolonged 21.85 14.64 10 436663 6883 63045466
Cholecystitis acute 21.84 14.64 15 436658 8245 63044104
Hypertonia 21.80 14.64 3 436670 4634 63047715
Aortic valve incompetence 21.78 14.64 7 436666 5981 63046368
Juvenile idiopathic arthritis 21.71 14.64 61 436612 3265 63049084
Red blood cell count decreased 21.67 14.64 177 436496 40468 63011881
Vitreous floaters 21.66 14.64 7 436666 5959 63046390
Upper limb fracture 21.61 14.64 63 436610 18905 63033444
Hypertriglyceridaemia 21.59 14.64 8 436665 6251 63046098
Eye irritation 21.54 14.64 78 436595 21893 63030456
Enthesophyte 21.52 14.64 10 436663 55 63052294
Supraventricular extrasystoles 21.50 14.64 3 436670 4586 63047763
Bronchospasm 21.48 14.64 55 436618 17225 63035124
Osteomyelitis 21.26 14.64 273 436400 25747 63026602
Rales 21.26 14.64 34 436639 12663 63039686
Bladder cancer 21.16 14.64 6 436667 5560 63046789
Congestive cardiomyopathy 21.16 14.64 8 436665 6174 63046175
Laboratory test abnormal 21.15 14.64 104 436569 26808 63025541
Hyperammonaemia 21.12 14.64 5 436668 5227 63047122
Stillbirth 21.08 14.64 10 436663 6740 63045609
Peripheral venous disease 21.01 14.64 180 436493 15297 63037052
Lung disorder 20.98 14.64 569 436104 61692 62990657
Facial pain 20.98 14.64 25 436648 10536 63041813
Inflammatory marker increased 20.97 14.64 98 436575 6741 63045608
Drug level below therapeutic 20.97 14.64 4 436669 4862 63047487
International normalised ratio decreased 20.96 14.64 3 436670 4498 63047851
Dental caries 20.90 14.64 26 436647 10753 63041596
Spinal meningioma benign 20.86 14.64 12 436661 109 63052240
Rash maculo-papular 20.84 14.64 131 436542 31765 63020584
Pain in extremity 20.82 14.64 2594 434079 328892 62723457
Polycystic ovaries 20.77 14.64 3 436670 4468 63047881
Pseudomonas infection 20.76 14.64 28 436645 11185 63041164
Internal haemorrhage 20.72 14.64 5 436668 5160 63047189
Hepatomegaly 20.71 14.64 31 436642 11858 63040491
Extrasystoles 20.69 14.64 5 436668 5155 63047194
Breast pain 20.69 14.64 18 436655 8780 63043569
Drug level above therapeutic 20.60 14.64 4 436669 4801 63047548
Neck mass 20.57 14.64 63 436610 3540 63048809
Affect lability 20.49 14.64 28 436645 11123 63041226
Accident 20.42 14.64 89 436584 5943 63046406
Breast cancer female 20.26 14.64 39 436634 13520 63038829
Arthritis bacterial 20.11 14.64 93 436580 6370 63045979
Sleep disorder due to a general medical condition 20.07 14.64 33 436640 12155 63040194
Sinus congestion 20.06 14.64 61 436612 18062 63034287
Hepatic cirrhosis 19.99 14.64 259 436414 24475 63027874
Abscess 19.99 14.64 54 436619 16614 63035735
Orthopnoea 19.98 14.64 9 436664 6252 63046097
Urine analysis abnormal 19.84 14.64 5 436668 5011 63047338
Photophobia 19.78 14.64 59 436614 17576 63034773
Enterococcal infection 19.77 14.64 15 436658 7833 63044516
Loss of employment 19.67 14.64 46 436627 2198 63050151
Gastroenteritis 19.63 14.64 105 436568 26485 63025864
Forced expiratory volume decreased 19.56 14.64 5 436668 4963 63047386
SARS-CoV-2 test positive 19.54 14.64 16 436657 8040 63044309
Heart rate abnormal 19.44 14.64 5 436668 4942 63047407
Lyme disease 19.40 14.64 60 436613 3389 63048960
Maternal exposure during breast feeding 19.35 14.64 3 436670 4238 63048111
Invasive ductal breast carcinoma 19.26 14.64 12 436661 6946 63045403
Maternal exposure timing unspecified 19.19 14.64 98 436575 6989 63045360
Snoring 19.11 14.64 3 436670 4199 63048150
Ileus paralytic 19.07 14.64 4 436669 4547 63047802
Paralysis 19.07 14.64 24 436649 9876 63042473
Thrombotic microangiopathy 18.92 14.64 27 436646 10534 63041815
Respiratory rate increased 18.91 14.64 41 436632 13607 63038742
Abnormal faeces 18.91 14.64 7 436666 5473 63046876
Transplant rejection 18.88 14.64 28 436645 10752 63041597
Photopsia 18.82 14.64 4 436669 4505 63047844
Treatment noncompliance 18.79 14.64 165 436508 37160 63015189
Spinal cord compression 18.77 14.64 3 436670 4145 63048204
Cellulitis gangrenous 18.74 14.64 9 436664 54 63052295
Oral mucosal blistering 18.67 14.64 8 436665 5725 63046624
Scratch 18.62 14.64 11 436662 6554 63045795
Osteonecrosis 18.59 14.64 96 436577 24434 63027915
Drug dose omission by device 18.58 14.64 5 436668 4796 63047553
Bursitis 18.57 14.64 358 436315 36683 63015666
Cardiac tamponade 18.43 14.64 5 436668 4770 63047579
Polyp 18.39 14.64 11 436662 6510 63045839
Diverticulum 18.35 14.64 34 436639 11957 63040392
Injection site bruising 18.25 14.64 192 436481 41718 63010631
Blood culture positive 18.20 14.64 5 436668 4730 63047619
Dermatitis bullous 18.15 14.64 19 436654 8489 63043860
Limb injury 18.04 14.64 102 436571 25375 63026974
Ketoacidosis 18.04 14.64 4 436669 4374 63047975
Ventricular septal defect 18.04 14.64 4 436669 4374 63047975
Premature rupture of membranes 17.88 14.64 6 436667 4987 63047362
Blood thyroid stimulating hormone increased 17.81 14.64 14 436659 7180 63045169
Aphonia 17.76 14.64 26 436647 10037 63042312
Facial bones fracture 17.75 14.64 3 436670 3979 63048370
Product residue present 17.74 14.64 3 436670 3976 63048373
Overwork 17.71 14.64 9 436664 62 63052287
Arteriospasm coronary 17.67 14.64 3 436670 3965 63048384
Cytomegalovirus infection reactivation 17.64 14.64 3 436670 3960 63048389
Maternal drugs affecting foetus 17.58 14.64 7 436666 5235 63047114
Blood glucose abnormal 17.55 14.64 17 436656 7875 63044474
Ocular toxicity 17.53 14.64 23 436650 687 63051662
Haemorrhagic stroke 17.45 14.64 9 436664 5783 63046566
Catheterisation cardiac 17.43 14.64 5 436668 4598 63047751
Anosmia 17.43 14.64 13 436660 6847 63045502
Tendonitis 17.40 14.64 209 436464 19406 63032943
Bunion operation 17.36 14.64 32 436641 1290 63051059
Tongue oedema 17.33 14.64 5 436668 4581 63047768
Limb operation 17.27 14.64 64 436609 3967 63048382
Localised infection 17.25 14.64 298 436375 29912 63022437
Visual field defect 17.23 14.64 12 436661 6549 63045800
Oxygen consumption increased 17.16 14.64 3 436670 3881 63048468
Clear cell renal cell carcinoma 17.10 14.64 34 436639 1451 63050898
COVID-19 pneumonia 17.07 14.64 46 436627 14163 63038186
Parotid gland enlargement 16.99 14.64 25 436648 833 63051516
Choking 16.97 14.64 26 436647 9853 63042496
Colon cancer 16.97 14.64 26 436647 9852 63042497
Urine abnormality 16.95 14.64 14 436659 7005 63045344
Bladder disorder 16.91 14.64 22 436651 8924 63043425
Hepatic necrosis 16.89 14.64 9 436664 5678 63046671
Arterial occlusive disease 16.88 14.64 10 436663 5948 63046401
Infusion site bruising 16.84 14.64 3 436670 3829 63048520
Infusion site haemorrhage 16.72 14.64 7 436666 5079 63047270
Sputum discoloured 16.72 14.64 57 436616 16290 63036059
Tooth extraction 16.70 14.64 28 436645 10236 63042113
Diffuse large B-cell lymphoma 16.69 14.64 13 436660 6699 63045650
Feeling drunk 16.64 14.64 4 436669 4138 63048211
Muscle relaxant therapy 16.56 14.64 12 436661 167 63052182
Breast mass 16.55 14.64 18 436655 7904 63044445
Large intestine polyp 16.53 14.64 19 436654 8138 63044211
Hydronephrosis 16.52 14.64 30 436643 10632 63041717
Gingival swelling 16.37 14.64 5 436668 4413 63047936
Amyotrophic lateral sclerosis 16.35 14.64 29 436644 1134 63051215
Device occlusion 16.32 14.64 16 436657 7371 63044978
Neutrophilia 16.30 14.64 5 436668 4401 63047948
Skin burning sensation 16.24 14.64 40 436633 12694 63039655
Sluggishness 16.16 14.64 8 436665 5261 63047088
Anxiety disorder 16.09 14.64 4 436669 4046 63048303
Retinal haemorrhage 16.08 14.64 7 436666 4962 63047387
Thrombophlebitis 16.08 14.64 5 436668 4363 63047986
Spinal fusion surgery 16.07 14.64 79 436594 5549 63046800
Sexual dysfunction 16.03 14.64 5 436668 4354 63047995
Ammonia increased 15.98 14.64 6 436667 4650 63047699
Culture urine positive 15.96 14.64 3 436670 3684 63048665
Breast cancer recurrent 15.92 14.64 5 436668 4336 63048013
Middle insomnia 15.90 14.64 40 436633 12603 63039746
Brain herniation 15.90 14.64 3 436670 3674 63048675
Pyelonephritis acute 15.89 14.64 6 436667 4635 63047714
Gallbladder disorder 15.88 14.64 71 436602 18771 63033578
Intervertebral disc space narrowing 15.79 14.64 27 436646 1025 63051324
Skin tightness 15.78 14.64 5 436668 4311 63048038
Catheter site infection 15.78 14.64 7 436666 4907 63047442
Humerus fracture 15.77 14.64 23 436650 8893 63043456
Facial paralysis 15.73 14.64 47 436626 13994 63038355
Multiple drug therapy 15.71 14.64 3 436670 3643 63048706
Dermatitis exfoliative 15.69 14.64 9 436664 5450 63046899
Formication 15.64 14.64 5 436668 4286 63048063
Hyperpyrexia 15.62 14.64 3 436670 3629 63048720
Drug screen positive 15.61 14.64 3 436670 3626 63048723
Left ventricular failure 15.48 14.64 10 436663 5677 63046672
Pelvic fracture 15.45 14.64 44 436629 13304 63039045
Tongue disorder 15.40 14.64 125 436548 10455 63041894
Hair texture abnormal 15.36 14.64 5 436668 4238 63048111
Lip oedema 15.35 14.64 4 436669 3920 63048429
Polydipsia 15.21 14.64 3 436670 3561 63048788
Product monitoring error 15.20 14.64 6 436667 4510 63047839
Aspergillus infection 15.19 14.64 20 436653 8073 63044276
Pharyngeal swelling 15.18 14.64 13 436660 6391 63045958
Impaired driving ability 15.17 14.64 6 436667 4505 63047844
Injury 15.10 14.64 632 436041 72615 62979734
Uterine leiomyoma 15.05 14.64 25 436648 9173 63043176
Gangrene 15.05 14.64 12 436661 6111 63046238
Aplasia pure red cell 15.04 14.64 6 436667 4481 63047868
Hepatic cancer 15.04 14.64 6 436667 4481 63047868
Neoplasm 15.01 14.64 17 436656 7328 63045021
Dysaesthesia 14.99 14.64 6 436667 4472 63047877
Soft tissue swelling 14.96 14.64 29 436644 1215 63051134
Trigeminal neuralgia 14.94 14.64 3 436670 3516 63048833
Renal pain 14.92 14.64 14 436659 6585 63045764
Fibrin D dimer increased 14.90 14.64 8 436665 5026 63047323
Bacterial test positive 14.90 14.64 9 436664 5298 63047051
Stridor 14.89 14.64 3 436670 3507 63048842
Hydrocephalus 14.87 14.64 9 436664 5291 63047058
Galactorrhoea 14.86 14.64 5 436668 4150 63048199
Coronary artery stenosis 14.86 14.64 7 436666 4737 63047612
Paradoxical drug reaction 14.85 14.64 5 436668 4147 63048202
Salt craving 14.83 14.64 10 436663 123 63052226
Abdominal hernia 14.79 14.64 8 436665 5004 63047345
Atypical pneumonia 14.78 14.64 6 436667 4434 63047915
Gastrointestinal perforation 14.77 14.64 3 436670 3488 63048861
Nail psoriasis 14.65 14.64 20 436653 621 63051728

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 2271.41 15.57 3421 60985 453330 34439195
Rheumatoid arthritis 1754.08 15.57 1009 63397 37229 34855296
Joint swelling 1666.66 15.57 1151 63255 58739 34833786
Drug intolerance 1527.26 15.57 1089 63317 58481 34834044
Contraindicated product administered 931.11 15.57 547 63859 20934 34871591
Synovitis 796.59 15.57 427 63979 13639 34878886
Treatment failure 775.38 15.57 661 63745 46036 34846489
C-reactive protein abnormal 711.96 15.57 339 64067 8371 34884154
Arthralgia 611.12 15.57 1109 63297 168932 34723593
Apparent death 607.64 15.57 235 64171 3409 34889116
Arthropathy 591.21 15.57 449 63957 26458 34866067
Musculoskeletal stiffness 567.55 15.57 555 63851 46125 34846400
Therapeutic product effect decreased 528.32 15.57 468 63938 34275 34858250
Bone erosion 527.32 15.57 218 64188 3797 34888728
Pain 525.36 15.57 1160 63246 203515 34689010
Red blood cell sedimentation rate abnormal 454.91 15.57 190 64216 3399 34889126
Diverticulitis 435.31 15.57 332 64074 19672 34872853
Psoriatic arthropathy 425.14 15.57 326 64080 19472 34873053
Drug hypersensitivity 408.12 15.57 614 63792 79915 34812610
Drug eruption 330.47 15.57 282 64124 19616 34872909
Mobility decreased 321.51 15.57 334 64072 29794 34862731
Loss of personal independence in daily activities 319.01 15.57 348 64058 32831 34859694
Hand deformity 310.46 15.57 147 64259 3578 34888947
Urticaria 307.88 15.57 470 63936 61907 34830618
Pain in extremity 297.93 15.57 694 63712 125819 34766706
Stomatitis 286.57 15.57 372 64034 42142 34850383
Red blood cell sedimentation rate increased 284.66 15.57 189 64217 8973 34883552
C-reactive protein increased 284.59 15.57 420 63986 53678 34838847
Death 273.13 15.57 202 64204 397847 34494678
Arthritis 229.71 15.57 286 64120 31060 34861465
Hypotension 228.56 15.57 63 64343 221586 34670939
Hypersensitivity 223.22 15.57 402 64004 60633 34831892
Sleep disorder due to general medical condition, insomnia type 219.82 15.57 85 64321 1231 34891294
Febrile neutropenia 217.00 15.57 8 64398 136841 34755684
Disability 215.88 15.57 125 64281 4640 34887885
Therapeutic product effect incomplete 203.08 15.57 347 64059 50194 34842331
Acute kidney injury 197.19 15.57 164 64242 304824 34587701
Rheumatoid nodule 191.02 15.57 98 64308 2849 34889676
Rheumatoid factor negative 190.03 15.57 69 64337 830 34891695
Alanine aminotransferase abnormal 183.71 15.57 112 64294 4576 34887949
Limb discomfort 182.21 15.57 156 64250 10891 34881634
Osteoarthritis 178.59 15.57 205 64201 20437 34872088
Impaired work ability 177.62 15.57 127 64279 6803 34885722
Anti-cyclic citrullinated peptide antibody positive 176.21 15.57 80 64326 1763 34890762
Anaemia 170.77 15.57 110 64296 233225 34659300
Peripheral swelling 170.23 15.57 411 63995 76130 34816395
Knee arthroplasty 169.48 15.57 127 64279 7317 34885208
Pulmonary thrombosis 163.38 15.57 124 64282 7283 34885242
Toxicity to various agents 161.44 15.57 84 64322 200278 34692247
Chondropathy 159.70 15.57 62 64344 908 34891617
Confusional state 158.07 15.57 36 64370 144124 34748401
Bone cyst 157.88 15.57 71 64335 1529 34890996
Tenosynovitis 153.47 15.57 99 64307 4471 34888054
Gastrointestinal disorder 150.95 15.57 244 64162 33704 34858821
Swelling 150.94 15.57 276 64130 42090 34850435
Enthesopathy 150.17 15.57 98 64308 4515 34888010
Drug tolerance decreased 149.87 15.57 73 64333 1894 34890631
Drug interaction 147.71 15.57 120 64286 225826 34666699
Malignant neoplasm progression 143.60 15.57 4 64402 88042 34804483
Lymphoma 143.03 15.57 144 64262 12363 34880162
Constipation 140.91 15.57 39 64367 136943 34755582
Terminal state 139.00 15.57 88 64318 3846 34888679
Onychoclasis 137.26 15.57 68 64338 1832 34890693
Joint ankylosis 130.87 15.57 62 64344 1510 34891015
Dehydration 128.19 15.57 40 64366 129929 34762596
Atlantoaxial instability 126.33 15.57 40 64366 305 34892220
Hepatic function abnormal 125.18 15.57 262 64144 44101 34848424
Thrombocytopenia 125.05 15.57 66 64340 156181 34736344
Herpes zoster 124.92 15.57 226 64180 34173 34858352
Spinal instability 124.11 15.57 40 64366 325 34892200
Mineral metabolism disorder 123.36 15.57 40 64366 332 34892193
Inflammation 121.21 15.57 200 64206 28095 34864430
Dislocation of vertebra 117.04 15.57 40 64366 397 34892128
Acne cystic 114.45 15.57 41 64365 473 34892052
Dizziness 114.21 15.57 141 64265 218380 34674145
Sarcoidosis 113.16 15.57 69 64337 2819 34889706
Overdose 112.03 15.57 17 64389 91042 34801483
Rhabdomyolysis 107.91 15.57 4 64402 68159 34824366
Drug specific antibody present 107.45 15.57 70 64336 3215 34889310
Vomiting 104.81 15.57 185 64221 247436 34645089
Tooth loss 104.18 15.57 73 64333 3785 34888740
Tongue disorder 101.77 15.57 82 64324 5257 34887268
Intervertebral disc space narrowing 101.50 15.57 46 64360 1009 34891516
Disease progression 100.06 15.57 37 64369 108040 34784485
Joint arthroplasty 99.07 15.57 43 64363 848 34891677
Pyrexia 98.96 15.57 301 64105 332712 34559813
Rheumatoid factor positive 98.51 15.57 40 64366 663 34891862
Decreased appetite 98.29 15.57 97 64309 166295 34726230
Somnolence 96.40 15.57 42 64364 111074 34781451
Neutropenia 94.21 15.57 90 64316 156688 34735837
Osteolysis 93.10 15.57 63 64343 3085 34889440
Bradycardia 92.94 15.57 14 64392 75404 34817121
Hyperkalaemia 92.47 15.57 10 64396 69379 34823146
Alopecia 92.24 15.57 163 64243 24192 34868333
Foot deformity 91.43 15.57 72 64334 4465 34888060
Hip arthroplasty 90.09 15.57 71 64335 4408 34888117
Joint stiffness 89.03 15.57 105 64301 10768 34881757
Seizure 88.82 15.57 41 64365 104816 34787709
Infection 87.89 15.57 366 64040 90549 34801976
Musculoskeletal discomfort 86.98 15.57 90 64316 7978 34884547
Intestinal sepsis 86.62 15.57 36 64370 635 34891890
Pulmonary fibrosis 84.17 15.57 134 64272 18262 34874263
Epistaxis 82.05 15.57 265 64141 57986 34834539
Gait inability 79.99 15.57 140 64266 20618 34871907
Agitation 79.82 15.57 7 64399 57392 34835133
Localised infection 78.95 15.57 127 64279 17460 34875065
Ill-defined disorder 78.87 15.57 112 64294 13797 34878728
Cardiac arrest 77.79 15.57 40 64366 96119 34796406
Osteosclerosis 77.15 15.57 41 64365 1283 34891242
Cytology abnormal 74.52 15.57 28 64378 373 34892152
Tendonitis 74.40 15.57 88 64318 9052 34883473
Fall 74.21 15.57 165 64241 202720 34689805
Liver function test increased 73.49 15.57 111 64295 14454 34878071
Drug use disorder 72.82 15.57 61 64345 4130 34888395
Nodule 71.60 15.57 75 64331 6744 34885781
Tooth fracture 71.09 15.57 57 64349 3628 34888897
Skin ulcer 70.72 15.57 138 64268 22078 34870447
Muscle spasms 70.17 15.57 299 64107 74702 34817823
End stage renal disease 69.96 15.57 84 64322 8777 34883748
Hepatic enzyme abnormal 69.29 15.57 50 64356 2716 34889809
Joint range of motion decreased 68.99 15.57 76 64330 7236 34885289
Hyponatraemia 68.98 15.57 33 64373 82658 34809867
Soft tissue swelling 68.98 15.57 29 64377 527 34891998
Photosensitivity reaction 68.65 15.57 91 64315 10503 34882022
Intentional overdose 67.65 15.57 3 64403 43671 34848854
Deep vein thrombosis 67.24 15.57 268 64138 64980 34827545
Abdominal pain 65.78 15.57 126 64280 163492 34729033
International normalised ratio increased 65.19 15.57 6 64400 47321 34845204
Ankylosing spondylitis 64.94 15.57 65 64341 5539 34886986
Hypokalaemia 64.82 15.57 14 64392 58200 34834325
Seronegative arthritis 62.88 15.57 33 64373 1006 34891519
Joint lock 61.90 15.57 35 64371 1240 34891285
Tachycardia 60.45 15.57 41 64365 84731 34807794
Ankle deformity 60.43 15.57 21 64385 220 34892305
Syncope 60.33 15.57 48 64358 91403 34801122
Haemorrhage 60.03 15.57 11 64395 51359 34841166
Platelet count decreased 59.59 15.57 80 64326 119637 34772888
Suicide attempt 59.57 15.57 3 64403 39113 34853412
Grip strength decreased 58.97 15.57 48 64358 3121 34889404
Plasma cell myeloma 58.79 15.57 5 64401 42032 34850493
Atrial fibrillation 58.71 15.57 84 64322 122309 34770216
Cardiac failure congestive 58.41 15.57 41 64365 83229 34809296
Psoriasis 57.77 15.57 180 64226 38632 34853893
Mental status changes 57.74 15.57 3 64403 38080 34854445
Dyspnoea 56.40 15.57 435 63971 376347 34516178
Hallucination 56.09 15.57 13 64393 51485 34841040
Skin laceration 54.33 15.57 89 64317 12420 34880105
Arthritis bacterial 53.32 15.57 56 64350 5050 34887475
Joint effusion 52.53 15.57 56 64350 5137 34887388
Blood glucose increased 52.11 15.57 29 64377 66689 34825836
Hypoglycaemia 51.74 15.57 18 64388 54622 34837903
Neutrophil count decreased 51.65 15.57 15 64391 51089 34841436
Pneumonia aspiration 51.11 15.57 8 64398 41895 34850630
Abdominal discomfort 50.24 15.57 231 64175 59604 34832921
Mass 49.84 15.57 67 64339 7838 34884687
Hepatic cirrhosis 49.67 15.57 103 64303 17211 34875314
Myalgia 49.64 15.57 49 64357 84061 34808464
Electrocardiogram QT prolonged 49.54 15.57 8 64398 40944 34851581
Musculoskeletal disorder 49.28 15.57 59 64347 6145 34886380
Product dose omission issue 49.13 15.57 91 64315 119620 34772905
Polyomavirus-associated nephropathy 49.04 15.57 47 64359 3797 34888728
Ureaplasma infection 48.21 15.57 20 64386 351 34892174
Liver disorder 48.15 15.57 152 64254 32845 34859680
Exposure via body fluid 48.12 15.57 15 64391 108 34892417
Cardio-respiratory arrest 47.73 15.57 21 64385 55252 34837273
Musculoskeletal pain 47.34 15.57 148 64258 31815 34860710
Urinary tract infection 47.34 15.57 51 64355 84030 34808495
Hyperglycaemia 47.11 15.57 8 64398 39472 34853053
Prerenal failure 46.20 15.57 35 64371 2049 34890476
Delirium 46.17 15.57 12 64394 43979 34848546
Fine motor skill dysfunction 46.11 15.57 33 64373 1769 34890756
Hospitalisation 45.50 15.57 24 64382 56878 34835647
Diabetes mellitus 45.47 15.57 189 64217 46684 34845841
Oral surgery 45.29 15.57 22 64384 567 34891958
Loss of consciousness 44.50 15.57 52 64354 82615 34809910
Finger deformity 44.07 15.57 30 64376 1483 34891042
Blood creatine phosphokinase increased 43.83 15.57 14 64392 44843 34847682
Physical disability 43.78 15.57 29 64377 1370 34891155
Pulmonary mass 43.74 15.57 82 64324 12730 34879795
Therapeutic response decreased 43.66 15.57 136 64270 29177 34863348
Tuberculin test positive 43.47 15.57 27 64379 1140 34891385
Rheumatoid lung 43.43 15.57 25 64381 917 34891608
Intentional product misuse 43.23 15.57 15 64391 45596 34846929
Interstitial lung disease 42.78 15.57 235 64171 65047 34827478
Granuloma 41.95 15.57 40 64366 3211 34889314
Cerebrovascular accident 40.85 15.57 58 64348 84753 34807772
Food intolerance 40.75 15.57 28 64378 1406 34891119
Red blood cell sedimentation rate 40.54 15.57 26 64380 1162 34891363
Abdominal distension 39.45 15.57 30 64376 58462 34834063
Respiratory failure 39.06 15.57 89 64317 108483 34784042
Tooth disorder 38.85 15.57 71 64335 10811 34881714
Granuloma skin 38.79 15.57 26 64380 1253 34891272
Dactylitis 38.63 15.57 23 64383 899 34891626
Medical device implantation 38.22 15.57 20 64386 606 34891919
Urinary retention 37.88 15.57 10 64396 36278 34856247
Dysarthria 37.44 15.57 9 64397 34773 34857752
Haematuria 37.34 15.57 23 64383 50043 34842482
X-ray abnormal 37.09 15.57 18 64388 463 34892062
Skin mass 36.87 15.57 41 64365 3944 34888581
Immobile 36.66 15.57 33 64373 2461 34890064
Limb deformity 36.39 15.57 19 64387 573 34891952
Flushing 35.67 15.57 8 64398 32412 34860113
Metabolic acidosis 35.55 15.57 18 64388 43662 34848863
Lactic acidosis 35.52 15.57 10 64396 34762 34857763
Coma 35.45 15.57 20 64386 45658 34846867
Stent placement 35.05 15.57 45 64361 5033 34887492
Gastrointestinal haemorrhage 34.76 15.57 69 64337 88408 34804117
Unresponsive to stimuli 34.22 15.57 5 64401 27564 34864961
Product use in unapproved indication 33.47 15.57 108 64298 117391 34775134
Blood parathyroid hormone decreased 33.12 15.57 25 64381 1455 34891070
Neoplasm malignant 33.08 15.57 96 64310 19809 34872716
Pulmonary embolism 32.93 15.57 280 64126 89466 34803059
Exostosis 32.82 15.57 42 64364 4681 34887844
Hypoxia 32.61 15.57 32 64374 55063 34837462
Coronary artery disease 32.29 15.57 25 64381 48280 34844245
Pyopneumothorax 32.08 15.57 10 64396 72 34892453
Asthenia 31.70 15.57 294 64112 244957 34647568
Respiratory distress 31.67 15.57 13 64393 35652 34856873
Blood creatinine increased 31.67 15.57 81 64325 94895 34797630
Blood pressure decreased 31.56 15.57 29 64377 51486 34841039
Depressed level of consciousness 31.50 15.57 20 64386 42821 34849704
Intestinal obstruction 31.14 15.57 3 64403 22819 34869706
Hypocalcaemia 31.11 15.57 4 64402 24285 34868240
Mycobacterium tuberculosis complex test positive 30.93 15.57 23 64383 1309 34891216
Suicidal ideation 30.89 15.57 18 64388 40370 34852155
Pancreatitis acute 30.85 15.57 7 64399 28134 34864391
Dermatitis psoriasiform 30.70 15.57 24 64382 1472 34891053
Dysphagia 30.69 15.57 42 64364 62339 34830186
Panniculitis 30.53 15.57 27 64379 1967 34890558
Chest pain 30.51 15.57 125 64281 126637 34765888
Hepatotoxicity 30.45 15.57 98 64308 21387 34871138
Septic shock 29.99 15.57 54 64352 71780 34820745
Hepatic enzyme increased 29.97 15.57 147 64259 38933 34853592
Hypomagnesaemia 29.48 15.57 3 64403 21848 34870677
Polyarthritis 29.41 15.57 39 64367 4501 34888024
Toxic epidermal necrolysis 29.13 15.57 3 64403 21643 34870882
Hepatic fibrosis 28.97 15.57 39 64367 4568 34887957
Renal impairment 28.96 15.57 84 64322 94429 34798096
Fibromyalgia 28.86 15.57 32 64374 3068 34889457
Respiratory arrest 28.76 15.57 8 64398 28035 34864490
Skin injury 28.65 15.57 28 64378 2317 34890208
Degenerative bone disease 28.61 15.57 9 64397 67 34892458
Histoplasmosis 28.26 15.57 23 64383 1495 34891030
Dysgeusia 28.24 15.57 7 64399 26490 34866035
Hepatic steatosis 28.09 15.57 86 64320 18276 34874249
Disorientation 28.04 15.57 13 64393 33175 34859350
Chills 27.88 15.57 68 64338 80975 34811550
Oedema 27.73 15.57 26 64380 45715 34846810
Wrong technique in product usage process 27.58 15.57 16 64390 35970 34856555
Condition aggravated 27.48 15.57 502 63904 191694 34700831
Lacrimal disorder 27.20 15.57 13 64393 323 34892202
Subdural haematoma 27.05 15.57 3 64403 20418 34872107
Neck pain 26.79 15.57 105 64301 25244 34867281
Oral disorder 26.76 15.57 36 64370 4213 34888312
Bursitis 26.69 15.57 41 64365 5417 34887108
Restlessness 26.64 15.57 7 64399 25475 34867050
Alanine aminotransferase increased 26.48 15.57 246 64160 80569 34811956
Foetal exposure during pregnancy 26.39 15.57 19 64387 38082 34854443
Latent tuberculosis 26.11 15.57 21 64385 1342 34891183
Wrist deformity 26.04 15.57 13 64393 356 34892169
Generalised tonic-clonic seizure 25.91 15.57 4 64402 21170 34871355
Pulmonary toxicity 25.70 15.57 43 64363 6104 34886421
Irritability 25.40 15.57 7 64399 24683 34867842
Lymphoedema 25.34 15.57 34 64372 3969 34888556
Speech disorder 25.12 15.57 8 64398 25678 34866847
Blood cholesterol abnormal 24.80 15.57 23 64383 1783 34890742
Therapy non-responder 24.36 15.57 139 64267 39007 34853518
Intentional product use issue 24.29 15.57 191 64215 59625 34832900
Heart block congenital 24.29 15.57 7 64399 37 34892488
White blood cell count increased 24.23 15.57 24 64382 41127 34851398
Multiple organ dysfunction syndrome 24.23 15.57 67 64339 76499 34816026
Accidental overdose 24.21 15.57 4 64402 20136 34872389
Hypertension 24.12 15.57 369 64037 136074 34756451
Renal failure 23.82 15.57 355 64051 130202 34762323
Orthostatic hypotension 23.75 15.57 9 64397 25910 34866615
Enzyme abnormality 23.67 15.57 11 64395 256 34892269
Gastric disorder 23.63 15.57 63 64343 12378 34880147
Cerebral haemorrhage 23.45 15.57 18 64388 34919 34857606
Splenic embolism 23.43 15.57 10 64396 189 34892336
Diarrhoea 23.36 15.57 544 63862 389368 34503157
Elbow operation 23.29 15.57 9 64397 130 34892395
Vasculitic rash 23.26 15.57 17 64389 942 34891583
Synovial cyst 23.22 15.57 25 64381 2319 34890206
Full blood count decreased 23.11 15.57 3 64403 18085 34874440
Shoulder operation 22.97 15.57 18 64388 1108 34891417
Fatigue 22.80 15.57 515 63891 370138 34522387
Cutaneous symptom 22.59 15.57 11 64395 285 34892240
Dysstasia 22.40 15.57 61 64345 12134 34880391
Blood pressure fluctuation 22.31 15.57 99 64307 25150 34867375
Epilepsy 22.29 15.57 6 64400 21489 34871036
Tendon disorder 22.28 15.57 27 64379 2848 34889677
Acute respiratory failure 21.98 15.57 15 64391 30913 34861612
Retinal scar 21.84 15.57 11 64395 307 34892218
Onycholysis 21.76 15.57 15 64391 757 34891768
Haematoma 21.67 15.57 10 64396 25595 34866930
Melaena 21.57 15.57 20 64386 35360 34857165
Ventricular tachycardia 21.56 15.57 11 64395 26568 34865957
Pulmonary cavitation 21.46 15.57 16 64390 914 34891611
Erythema 21.42 15.57 254 64152 88526 34803999
Hypervolaemia 21.41 15.57 5 64401 19704 34872821
Rash maculo-papular 21.31 15.57 13 64393 28438 34864087
Bone marrow oedema 21.20 15.57 14 64392 658 34891867
Cytomegalovirus syndrome 21.13 15.57 8 64398 109 34892416
Aortic bruit 21.13 15.57 10 64396 243 34892282
Cytomegalovirus viraemia 21.07 15.57 44 64362 7386 34885139
Injury 21.03 15.57 6 64400 20681 34871844
Tooth extraction 21.02 15.57 34 64372 4694 34887831
C-reactive protein decreased 20.98 15.57 22 64384 1980 34890545
Head injury 20.97 15.57 4 64402 18156 34874369
Drug reaction with eosinophilia and systemic symptoms 20.92 15.57 18 64388 32994 34859531
Sideroblastic anaemia 20.90 15.57 10 64396 249 34892276
COVID-19 20.90 15.57 73 64333 77477 34815048
Ossicle disorder 20.78 15.57 6 64400 32 34892493
Disturbance in attention 20.65 15.57 11 64395 25934 34866591
Arthrodesis 20.60 15.57 12 64394 450 34892075
Lymphocyte count decreased 20.48 15.57 8 64398 22614 34869911
Memory impairment 20.48 15.57 30 64376 43288 34849237
Surgery 20.45 15.57 65 64341 14092 34878433
Ascites 20.35 15.57 34 64372 46537 34845988
Medication error 20.11 15.57 11 64395 25554 34866971
Spina bifida occulta 20.11 15.57 5 64401 13 34892512
Dysphonia 20.00 15.57 9 64397 23374 34869151
Impaired healing 19.99 15.57 68 64338 15266 34877259
Diaphragmatic injury 19.96 15.57 8 64398 128 34892397
Lupus-like syndrome 19.93 15.57 25 64381 2731 34889794
Steatorrhoea 19.92 15.57 14 64392 729 34891796
Lethargy 19.91 15.57 28 64378 41094 34851431
Emphysema 19.91 15.57 50 64356 9475 34883050
Shoulder arthroplasty 19.88 15.57 12 64394 481 34892044
Thrombosis 19.87 15.57 160 64246 50298 34842227
Fear of injection 19.84 15.57 19 64387 1533 34890992
Full blood count abnormal 19.76 15.57 5 64401 18663 34873862
Vision blurred 19.68 15.57 34 64372 45929 34846596
Cell-mediated cytotoxicity 19.64 15.57 6 64400 40 34892485
Anaphylactic shock 19.53 15.57 3 64403 15938 34876587
Altered state of consciousness 19.29 15.57 9 64397 22884 34869641
Unevaluable event 19.20 15.57 19 64387 32571 34859954
Fluid retention 19.16 15.57 13 64393 26874 34865651
Nail pitting 19.05 15.57 10 64396 305 34892220
Chronic kidney disease 19.03 15.57 29 64377 41181 34851344
Diffuse idiopathic skeletal hyperostosis 18.92 15.57 6 64400 46 34892479
Immobilisation syndrome 18.90 15.57 10 64396 310 34892215
Vitello-intestinal duct remnant 18.80 15.57 8 64398 150 34892375
Ejection fraction decreased 18.67 15.57 6 64400 19148 34873377
Cartilage injury 18.52 15.57 12 64394 546 34891979
Cardiac granuloma 18.43 15.57 4 64402 4 34892521
Upper respiratory tract infection 18.39 15.57 114 64292 32945 34859580
Vitamin B1 decreased 18.39 15.57 10 64396 328 34892197
Paternal drugs affecting foetus 18.38 15.57 6 64400 51 34892474
Ileus 18.29 15.57 4 64402 16495 34876030
Oral pustule 18.18 15.57 9 64397 242 34892283
Product administration error 18.04 15.57 4 64402 16340 34876185
Dental caries 17.98 15.57 31 64375 4508 34888017
Drug withdrawal syndrome 17.98 15.57 7 64399 19827 34872698
Joint injury 17.98 15.57 47 64359 9126 34883399
Hypophagia 17.95 15.57 11 64395 24011 34868514
Gastritis 17.82 15.57 9 64397 21864 34870661
Haemoptysis 17.79 15.57 23 64383 34983 34857542
Swollen joint count increased 17.75 15.57 9 64397 255 34892270
Arrhythmia 17.72 15.57 24 64382 35784 34856741
Dyspnoea exertional 17.64 15.57 33 64373 43246 34849279
Blood bilirubin increased 17.64 15.57 27 64379 38269 34854256
Fracture 17.63 15.57 39 64367 6810 34885715
Granulomatous dermatitis 17.59 15.57 9 64397 260 34892265
Erythema elevatum diutinum 17.58 15.57 5 64401 25 34892500
Transient ischaemic attack 17.57 15.57 15 64391 27598 34864927
Erectile dysfunction 17.56 15.57 8 64398 20629 34871896
Carbon dioxide abnormal 17.38 15.57 8 64398 182 34892343
Cerebral infarction 17.36 15.57 15 64391 27440 34865085
Sensitivity to weather change 17.27 15.57 18 64388 1608 34890917
Otospondylomegaepiphyseal dysplasia 17.19 15.57 7 64399 117 34892408
Anal hypoaesthesia 17.16 15.57 4 64402 7 34892518
Renal tubular necrosis 16.99 15.57 4 64402 15676 34876849
Diabetic ketoacidosis 16.96 15.57 6 64400 18026 34874499
Tuberculosis 16.87 15.57 44 64362 8533 34883992
Hernia pain 16.86 15.57 9 64397 284 34892241
Shock 16.82 15.57 12 64394 24167 34868358
Empyema 16.80 15.57 25 64381 3211 34889314
Soft tissue inflammation 16.66 15.57 7 64399 127 34892398
Carditis 16.62 15.57 8 64398 202 34892323
Stress ulcer 16.61 15.57 6 64400 71 34892454
Exposure via father 16.56 15.57 7 64399 129 34892396
Urinary incontinence 16.56 15.57 7 64399 18867 34873658
Ventricular fibrillation 16.49 15.57 11 64395 22943 34869582
C-reactive protein 16.41 15.57 7 64399 132 34892393
Undifferentiated connective tissue disease 16.41 15.57 5 64401 33 34892492
Blood potassium increased 16.37 15.57 5 64401 16490 34876035
Pulmonary granuloma 16.37 15.57 17 64389 1513 34891012
Motor dysfunction 16.06 15.57 38 64368 6936 34885589
Ulcer 16.04 15.57 44 64362 8791 34883734
Pallor 16.02 15.57 14 64392 25466 34867059
Aphthous ulcer 15.86 15.57 31 64375 4964 34887561
Aphasia 15.79 15.57 10 64396 21444 34871081
Dyskinesia 15.75 15.57 11 64395 22402 34870123
Urticarial vasculitis 15.69 15.57 5 64401 39 34892486
Neutrophil count increased 15.63 15.57 6 64400 17140 34875385

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 6120.21 13.77 14348 346154 1066565 78317321
Drug intolerance 5601.12 13.77 6414 354088 257705 79126181
Joint swelling 4634.96 13.77 6094 354408 282552 79101334
Contraindicated product administered 3941.08 13.77 4177 356325 153361 79230525
Synovitis 3863.70 13.77 4049 356453 146685 79237201
Rheumatoid arthritis 3780.42 13.77 4679 355823 203791 79180095
Treatment failure 3211.12 13.77 3902 356600 166584 79217302
Arthropathy 2907.53 13.77 3785 356717 173326 79210560
Therapeutic product effect decreased 2548.51 13.77 3411 357091 160452 79223434
Hand deformity 1845.28 13.77 2311 358191 101608 79282278
Arthralgia 1823.74 13.77 6196 354306 565607 78818279
Swelling 1781.06 13.77 3370 357132 213341 79170545
Pain 1672.37 13.77 6938 353564 696864 78687022
Pemphigus 1584.96 13.77 2098 358404 97484 79286402
Death 1511.34 13.77 355 360147 566159 78817727
Abdominal discomfort 1498.78 13.77 3421 357081 247306 79136580
Anti-cyclic citrullinated peptide antibody positive 1482.04 13.77 1853 358649 81290 79302596
Systemic lupus erythematosus 1476.70 13.77 2247 358255 118902 79264984
C-reactive protein abnormal 1444.27 13.77 1413 359089 46954 79336932
Musculoskeletal stiffness 1433.99 13.77 2719 357783 172289 79211597
Alopecia 1425.24 13.77 3195 357307 228160 79155726
Acute kidney injury 1368.36 13.77 334 360168 519070 78864816
Glossodynia 1355.63 13.77 1984 358518 101353 79282533
Drug hypersensitivity 1354.56 13.77 3669 356833 295247 79088639
Rheumatoid factor positive 1350.54 13.77 1505 358997 58334 79325552
Hepatic enzyme increased 1339.41 13.77 2708 357794 179902 79203984
Hypersensitivity 1291.81 13.77 3321 357181 258918 79124968
Peripheral swelling 1269.31 13.77 3357 357145 266260 79117626
Hypotension 1096.88 13.77 316 360186 440001 78943885
Pericarditis 1076.67 13.77 1793 358709 102443 79281443
Toxicity to various agents 1034.43 13.77 311 360191 421229 78962657
Red blood cell sedimentation rate abnormal 1016.98 13.77 807 359695 20156 79363730
Completed suicide 1016.40 13.77 19 360483 245748 79138138
Psoriatic arthropathy 994.46 13.77 1478 359024 76521 79307365
Wound 968.17 13.77 1819 358683 114360 79269526
Therapeutic product effect incomplete 966.83 13.77 2040 358462 139605 79244281
Drug interaction 910.88 13.77 369 360133 414814 78969072
Febrile neutropenia 898.70 13.77 33 360469 230966 79152920
Red blood cell sedimentation rate increased 855.33 13.77 1047 359455 44895 79338991
Anaemia 852.99 13.77 476 360026 444539 78939347
Loss of personal independence in daily activities 840.84 13.77 1595 358907 100985 79282901
Helicobacter infection 839.01 13.77 1286 359216 68418 79315468
Duodenal ulcer perforation 787.68 13.77 1215 359287 64996 79318890
Discomfort 773.64 13.77 1736 358766 123881 79260005
Rash 762.03 13.77 4840 355662 573518 78810368
Constipation 742.36 13.77 183 360319 282867 79101019
Infection 739.26 13.77 2588 357914 239124 79144762
Bone erosion 729.48 13.77 622 359880 17225 79366661
Infusion related reaction 715.20 13.77 2478 358024 227759 79156127
Gastrointestinal disorder 711.69 13.77 1652 358850 120553 79263333
C-reactive protein increased 702.43 13.77 1699 358803 127328 79256558
Impaired healing 702.33 13.77 1350 359152 86305 79297581
Mobility decreased 679.27 13.77 1622 358880 120553 79263333
Sleep disorder due to general medical condition, insomnia type 675.98 13.77 907 359595 42649 79341237
Irritable bowel syndrome 668.41 13.77 1090 359412 61151 79322735
Folliculitis 663.94 13.77 1020 359482 54360 79329526
Muscle injury 661.99 13.77 950 359552 47611 79336275
Dehydration 613.84 13.77 180 360322 248007 79135879
Osteoarthritis 605.27 13.77 1266 359236 86043 79297843
Malignant neoplasm progression 591.15 13.77 4 360498 135986 79247900
Lower respiratory tract infection 576.64 13.77 1579 358923 127641 79256245
Hyponatraemia 554.21 13.77 74 360428 177774 79206112
Arthritis 545.00 13.77 1436 359066 113444 79270442
Cardiac arrest 544.97 13.77 68 360434 172028 79211858
Thrombocytopenia 533.81 13.77 266 360236 264993 79118893
Ill-defined disorder 531.81 13.77 1018 359484 64857 79319029
Rheumatoid nodule 519.44 13.77 509 359993 16929 79366957
Bradycardia 511.54 13.77 24 360478 135533 79248353
Overdose 508.98 13.77 106 360396 184100 79199786
Seizure 502.91 13.77 118 360384 188716 79195170
Somnolence 492.48 13.77 232 360270 238749 79145137
Inflammation 491.41 13.77 1217 359285 92536 79291350
Blister 488 13.77 1414 359088 118062 79265824
Disease progression 483.53 13.77 119 360383 184243 79199643
Stomatitis 476.70 13.77 1604 358898 145153 79238733
Neutropenia 475.61 13.77 363 360139 287347 79096539
Condition aggravated 464.91 13.77 3858 356644 497266 78886620
Sinusitis 446.39 13.77 1909 358593 193592 79190294
Knee arthroplasty 443.55 13.77 742 359760 42506 79341380
Fibromyalgia 440.07 13.77 928 359574 63412 79320474
Intentional overdose 434.55 13.77 9 360493 105951 79277935
Product use issue 433.08 13.77 1988 358514 207834 79176052
Hyperkalaemia 426.04 13.77 22 360480 114376 79269510
Maternal exposure during pregnancy 424.72 13.77 1471 359031 135067 79248819
Tremor 417.39 13.77 125 360377 169958 79213928
Foot deformity 397.67 13.77 517 359985 23557 79360329
Disability 397.03 13.77 437 360065 16683 79367203
Fall 386.54 13.77 1038 359464 486591 78897295
Atrial fibrillation 383.81 13.77 208 360294 197678 79186208
Dyspnoea 372.69 13.77 2311 358191 854714 78529172
Hip arthroplasty 368.71 13.77 615 359887 35141 79348745
Joint range of motion decreased 353.33 13.77 580 359922 32702 79351184
Tenosynovitis 352.02 13.77 392 360110 15162 79368724
Blood cholesterol increased 348.67 13.77 998 359504 82722 79301164
Drug tolerance decreased 344.66 13.77 356 360146 12622 79371264
Hypokalaemia 340.66 13.77 113 360389 143927 79239959
Electrocardiogram QT prolonged 337.77 13.77 17 360485 90369 79293517
Tachycardia 330.18 13.77 197 360305 177571 79206315
Rhabdomyolysis 328.25 13.77 40 360462 103091 79280795
Respiratory failure 324.22 13.77 209 360293 180702 79203184
Depressed level of consciousness 318.92 13.77 33 360469 96619 79287267
Osteoporosis 317.46 13.77 734 359768 53378 79330508
Dizziness 317.17 13.77 1265 359237 525176 78858710
Platelet count decreased 314.69 13.77 251 360251 194413 79189473
Cardio-respiratory arrest 313.28 13.77 56 360446 108454 79275432
Musculoskeletal disorder 312.07 13.77 433 360069 21015 79362871
Sepsis 308.94 13.77 462 360040 268966 79114920
Hypoglycaemia 303.11 13.77 48 360454 101546 79282340
Adverse event 302.17 13.77 769 359733 59445 79324441
Rheumatic fever 299.97 13.77 495 360007 28030 79355856
Suicide attempt 290.70 13.77 22 360480 82910 79300976
Joint stiffness 287.42 13.77 596 359906 40234 79343652
Agitation 286.70 13.77 52 360450 99663 79284223
Drug eruption 285.77 13.77 621 359881 43314 79340572
Therapeutic response decreased 285.23 13.77 804 359698 66049 79317837
Neutrophil count decreased 283.48 13.77 43 360459 93916 79289970
Granuloma skin 283.00 13.77 273 360229 8901 79374985
Blood parathyroid hormone decreased 279.77 13.77 289 360213 10247 79373639
Cardiac failure congestive 278.52 13.77 148 360354 142254 79241632
Gastrointestinal haemorrhage 276.70 13.77 162 360340 147557 79236329
Nasopharyngitis 275.85 13.77 2029 358473 251852 79132034
Swollen joint count increased 272.88 13.77 421 360081 22506 79361380
Cerebrovascular accident 272.02 13.77 184 360318 155108 79228778
Metabolic acidosis 270.17 13.77 29 360473 82500 79301386
Product dose omission issue 268.97 13.77 440 360062 247097 79136789
Hallucination 266.25 13.77 36 360466 85709 79298177
Cardiac failure 261.29 13.77 191 360311 154651 79229235
Pneumonia aspiration 258.76 13.77 10 360492 66957 79316929
Hypoxia 258.51 13.77 73 360429 103170 79280716
Panniculitis 256.58 13.77 298 360204 12073 79371813
Syncope 253.54 13.77 262 360240 179187 79204699
Lactic acidosis 248.50 13.77 18 360484 70341 79313545
International normalised ratio increased 246.13 13.77 43 360459 84678 79299208
Pain in extremity 244.46 13.77 2621 357881 361917 79021969
Mental status changes 239.77 13.77 16 360486 66943 79316943
Pyrexia 238.85 13.77 1944 358558 676765 78707121
Vision blurred 236.86 13.77 91 360411 105807 79278079
Abdominal pain 230.02 13.77 943 359559 388626 78995260
Pulmonary fibrosis 228.24 13.77 570 359932 43542 79340344
Grip strength decreased 223.91 13.77 375 360127 21494 79362392
Respiratory arrest 220.98 13.77 9 360493 57541 79326345
Coma 217.73 13.77 91 360411 100558 79283328
Neoplasm progression 217.65 13.77 3 360499 51679 79332207
Unresponsive to stimuli 216.68 13.77 8 360494 55780 79328106
Urinary tract infection 216.64 13.77 585 359917 273927 79109959
Hyperglycaemia 214.91 13.77 31 360471 70304 79313582
Sedation 214.39 13.77 4 360498 51891 79331995
Chest discomfort 209.56 13.77 189 360313 137855 79246031
Adverse drug reaction 209.51 13.77 719 359783 65673 79318213
Nodule 208.90 13.77 374 360128 22620 79361266
Multiple organ dysfunction syndrome 207.21 13.77 145 360357 120101 79263785
Rheumatoid lung 204.93 13.77 163 360339 4082 79379804
Finger deformity 202.04 13.77 207 360295 7267 79376619
Musculoskeletal pain 200.05 13.77 955 359547 101399 79282487
Oedema peripheral 195.79 13.77 542 359960 251746 79132140
Cognitive disorder 195.61 13.77 39 360463 69887 79313999
Pulmonary embolism 194.07 13.77 297 360205 171357 79212529
Blood glucose increased 193.72 13.77 142 360360 114833 79269053
Intentional product misuse 193.40 13.77 94 360408 95071 79288815
Plasma cell myeloma 192.85 13.77 12 360490 53247 79330639
Enthesopathy 192.80 13.77 250 360252 11358 79372528
Vomiting 191.80 13.77 2005 358497 663823 78720063
Balance disorder 191.44 13.77 104 360398 98753 79285133
COVID-19 185.87 13.77 265 360237 157409 79226477
Dysarthria 184.45 13.77 40 360462 67582 79316304
Serotonin syndrome 183.89 13.77 4 360498 45023 79338863
Anxiety 183.23 13.77 547 359955 247965 79135921
Chest pain 180.87 13.77 661 359841 281643 79102243
Urinary retention 180.09 13.77 22 360480 56608 79327278
Aggression 180.06 13.77 13 360489 50945 79332941
Renal failure 178.28 13.77 403 360099 200565 79183321
Decreased appetite 174.44 13.77 875 359627 341543 79042343
Skin ulcer 173.98 13.77 590 359912 53560 79330326
Ascites 173.90 13.77 62 360440 75500 79308386
Pancytopenia 173.14 13.77 302 360200 165443 79218443
Blood pressure decreased 171.29 13.77 120 360382 99346 79284540
Orthostatic hypotension 171.02 13.77 25 360477 56139 79327747
Respiratory distress 170.79 13.77 29 360473 58310 79325576
Cerebral haemorrhage 170.32 13.77 28 360474 57645 79326241
Loss of consciousness 170.04 13.77 312 360190 167631 79216255
Hyperhidrosis 169.44 13.77 264 360238 151228 79232658
Apparent death 166.84 13.77 123 360379 2742 79381144
Blood creatine phosphokinase increased 166.80 13.77 46 360456 66044 79317842
Sciatica 166.34 13.77 424 360078 32798 79351088
White blood cell count decreased 165.86 13.77 379 360123 187909 79195977
Deformity 164.45 13.77 210 360292 9395 79374491
Dysphagia 163.95 13.77 186 360316 121950 79261936
Pleural effusion 163.56 13.77 252 360250 145010 79238876
Myalgia 163.25 13.77 374 360128 185267 79198619
Pulmonary oedema 160.72 13.77 100 360402 88154 79295732
Hypomagnesaemia 160.08 13.77 14 360488 46897 79336989
Lethargy 159.63 13.77 84 360418 81208 79302678
Rheumatoid factor negative 158.92 13.77 86 360416 1087 79382799
Dislocation of vertebra 158.72 13.77 187 360315 7693 79376193
Drug reaction with eosinophilia and systemic symptoms 157.91 13.77 47 360455 64197 79319689
Disorientation 157.85 13.77 44 360458 62732 79321154
Liver function test increased 157.70 13.77 466 360036 39307 79344579
Asthenia 157.07 13.77 1517 358985 510172 78873714
Haematuria 155.84 13.77 58 360444 68778 79315108
Restlessness 155.63 13.77 15 360487 46477 79337409
Skin necrosis 155.19 13.77 287 360215 17800 79366086
Melaena 154.38 13.77 42 360460 60848 79323038
Encephalopathy 153.91 13.77 56 360446 67341 79316545
Impaired work ability 153.67 13.77 300 360202 19381 79364505
Chills 152.36 13.77 309 360193 159925 79223961
Blood creatinine increased 149.15 13.77 297 360205 154760 79229126
Septic shock 148.10 13.77 203 360299 122598 79261288
Sleep disorder 148.00 13.77 772 359730 84905 79298981
Haemorrhage 147.78 13.77 117 360385 91001 79292885
Renal impairment 147.71 13.77 307 360195 157476 79226410
Hypervolaemia 147.70 13.77 12 360490 42678 79341208
Disturbance in attention 147.07 13.77 26 360476 50775 79333111
Wrong technique in product usage process 147.04 13.77 75 360427 73800 79310086
Type 2 diabetes mellitus 144.47 13.77 576 359926 56546 79327340
Limb deformity 144.39 13.77 124 360378 3466 79380420
Ulcer 143.34 13.77 376 360126 29596 79354290
Abnormal behaviour 142.21 13.77 5 360497 36416 79347470
Acute myocardial infarction 142.07 13.77 86 360416 76950 79306936
Tuberculin test positive 141.75 13.77 120 360382 3288 79380598
Joint effusion 141.15 13.77 275 360227 17739 79366147
Pancreatitis acute 140.14 13.77 27 360475 49577 79334309
Ankylosing spondylitis 139.50 13.77 220 360282 11985 79371901
Pneumonia 138.50 13.77 2126 358376 658120 78725766
Night sweats 137.97 13.77 533 359969 51562 79332324
Urticaria 136.91 13.77 1359 359143 183842 79200044
Palmar-plantar erythrodysaesthesia syndrome 135.09 13.77 3 360499 33131 79350755
Altered state of consciousness 134.61 13.77 19 360483 43803 79340083
Rectal haemorrhage 134.10 13.77 90 360412 76210 79307676
Ventricular tachycardia 134.06 13.77 16 360486 41919 79341967
Intentional self-injury 131.92 13.77 3 360499 32416 79351470
Flushing 131.39 13.77 123 360379 88145 79295741
Joint destruction 130.09 13.77 147 360355 5778 79378108
Oral mucosal exfoliation 129.94 13.77 82 360420 1403 79382483
Generalised tonic-clonic seizure 128.15 13.77 22 360480 43888 79339998
Alanine aminotransferase abnormal 127.47 13.77 178 360324 8689 79375197
Haematoma 126.81 13.77 39 360463 52156 79331730
Coronary artery disease 126.58 13.77 69 360433 65405 79318481
Hallucination, visual 126.05 13.77 5 360497 32724 79351162
Seronegative arthritis 125.11 13.77 129 360373 4563 79379323
Haemoglobin decreased 124.55 13.77 548 359954 221571 79162315
Toxic epidermal necrolysis 122.34 13.77 26 360476 44555 79339331
Acute respiratory failure 122.21 13.77 58 360444 59483 79324403
Joint injury 122.20 13.77 365 360137 30970 79352916
Psychotic disorder 120.27 13.77 21 360481 41381 79342505
Neuropathy peripheral 119.95 13.77 290 360212 141015 79242871
Joint laxity 119.61 13.77 93 360409 2251 79381635
Haematochezia 119.23 13.77 132 360370 87513 79296373
Lymphocyte count decreased 119.17 13.77 33 360469 47256 79336630
Musculoskeletal deformity 119.12 13.77 79 360423 1477 79382409
Cerebral infarction 118.66 13.77 30 360472 45646 79338240
Dyspnoea exertional 117.50 13.77 132 360370 86941 79296945
Haemoptysis 117.34 13.77 53 360449 55946 79327940
Red blood cell sedimentation rate 116.99 13.77 135 360367 5430 79378456
Dysgeusia 116.89 13.77 56 360446 57121 79326765
Physical disability 116.84 13.77 106 360396 3192 79380694
Drug withdrawal syndrome 116.74 13.77 11 360491 34707 79349179
Abdominal distension 116.07 13.77 228 360274 119422 79264464
Chronic kidney disease 114.97 13.77 79 360423 66075 79317811
Arrhythmia 113.55 13.77 68 360434 61204 79322682
Breast cancer stage III 113.52 13.77 178 360324 9648 79374238
Drug level increased 113.26 13.77 21 360481 39630 79344256
Accidental overdose 112.98 13.77 21 360481 39560 79344326
Blood bilirubin increased 111.28 13.77 82 360420 66150 79317736
Joint arthroplasty 110.94 13.77 95 360407 2645 79381241
Liver injury 110.40 13.77 528 359974 56086 79327800
Urinary incontinence 109.95 13.77 25 360477 40884 79343002
Blood calcium decreased 109.93 13.77 9 360493 31810 79352076
Cardiogenic shock 109.91 13.77 27 360475 41887 79341999
Fluid retention 109.03 13.77 93 360409 69716 79314170
Ejection fraction decreased 108.56 13.77 14 360488 34563 79349323
Exostosis 108.14 13.77 237 360265 16621 79367265
Aphasia 108.11 13.77 38 360464 46694 79337192
Dyskinesia 107.79 13.77 34 360468 44739 79339147
Pallor 107.07 13.77 46 360456 50016 79333870
Subdural haematoma 105.59 13.77 10 360492 31424 79352462
Circulatory collapse 105.37 13.77 21 360481 37647 79346239
Adverse reaction 105.22 13.77 167 360335 9147 79374739
Inappropriate antidiuretic hormone secretion 104.93 13.77 3 360499 26310 79357576
Gastric disorder 104.91 13.77 390 360112 37043 79346843
Contusion 104.77 13.77 1081 359421 147695 79236191
Wrist deformity 101.58 13.77 81 360421 2036 79381850
Ear pain 101.09 13.77 353 360149 32516 79351370
Dysuria 100.99 13.77 52 360450 50899 79332987
Intentional product use issue 100.91 13.77 1092 359410 151020 79232866
Labelled drug-drug interaction medication error 100.80 13.77 6 360496 27644 79356242
Bone swelling 100.74 13.77 74 360428 1640 79382246
Chronic obstructive pulmonary disease 100.19 13.77 144 360358 85275 79298611
Blood urea increased 99.41 13.77 48 360454 48742 79335144
Clostridium difficile colitis 99.15 13.77 14 360488 32269 79351617
Femur fracture 98.73 13.77 391 360111 38261 79345625
Sinus tachycardia 98.30 13.77 23 360479 36885 79347001
Diabetic ketoacidosis 97.61 13.77 18 360484 34104 79349782
Poisoning 96.86 13.77 4 360498 25268 79358618
Sinus bradycardia 96.75 13.77 4 360498 25243 79358643
Cholestasis 96.32 13.77 58 360444 52051 79331835
Arthrodesis 94.50 13.77 82 360420 2325 79381561
Tumour lysis syndrome 94.48 13.77 3 360499 23936 79359950
Foot operation 94.48 13.77 123 360379 5610 79378276
Transient ischaemic attack 94.16 13.77 61 360441 52634 79331252
Full blood count abnormal 93.48 13.77 33 360469 40441 79343445
Dry skin 92.93 13.77 102 360400 67893 79315993
Neutropenic sepsis 92.55 13.77 8 360494 27056 79356830
Loose body in joint 92.54 13.77 63 360439 1232 79382654
Respiratory depression 92.25 13.77 9 360493 27621 79356265
Upper gastrointestinal haemorrhage 91.77 13.77 36 360466 41344 79342542
Haemorrhage intracranial 91.63 13.77 7 360495 26186 79357700
Full blood count decreased 91.51 13.77 8 360494 26811 79357075
Ventricular fibrillation 90.99 13.77 17 360485 31909 79351977
Hepatic enzyme abnormal 90.95 13.77 142 360360 7668 79376218
Diverticulitis 90.71 13.77 430 360072 45506 79338380
Cough 90.65 13.77 1142 359360 365647 79018239
Angioedema 90.35 13.77 127 360375 75908 79307978
Deep vein thrombosis 89.88 13.77 265 360237 120654 79263232
Cardiac disorder 89.47 13.77 99 360403 65658 79318228
Withdrawal syndrome 89 13.77 9 360493 26845 79357041
Premature delivery 88.99 13.77 4 360498 23463 79360423
Surgical failure 88.84 13.77 53 360449 816 79383070
Tendonitis 87.69 13.77 272 360230 23558 79360328
Hypocalcaemia 87.57 13.77 59 360443 49865 79334021
Basal cell carcinoma 87.47 13.77 368 360134 37007 79346879
Presyncope 87.36 13.77 38 360464 41016 79342870
Eosinophilia 87.34 13.77 48 360454 45297 79338589
Suicidal ideation 87.28 13.77 131 360371 76209 79307677
Acute myeloid leukaemia 86.85 13.77 17 360485 30868 79353018
Anti-cyclic citrullinated peptide antibody 86.40 13.77 119 360383 5733 79378153
Ileus 86.31 13.77 9 360493 26202 79357684
Depressed mood 85.44 13.77 57 360445 48423 79335463
Shoulder arthroplasty 85.29 13.77 89 360413 3193 79380693
Mucosal inflammation 85.15 13.77 131 360371 75449 79308437
Gait inability 85.15 13.77 506 359996 58411 79325475
Myoclonus 84.94 13.77 12 360490 27648 79356238
Pericardial effusion 84.72 13.77 52 360450 46185 79337701
Irritability 84.56 13.77 40 360462 41104 79342782
Fatigue 84.32 13.77 5067 355435 924660 78459226
Limb discomfort 83.65 13.77 332 360170 32518 79351368
Blood potassium decreased 82.89 13.77 54 360448 46458 79337428
Bone pain 82.57 13.77 78 360424 55664 79328222
Bacteraemia 82.53 13.77 23 360479 32801 79351085
Fine motor skill dysfunction 82.22 13.77 111 360391 5246 79378640
Haematemesis 81.16 13.77 70 360432 52194 79331692
Shock 81.16 13.77 48 360454 43500 79340386
Obstructive airways disorder 81.07 13.77 21 360481 31438 79352448
Small intestinal obstruction 81.06 13.77 13 360489 27259 79356627
Product use in unapproved indication 81.03 13.77 732 359770 249627 79134259
Weight increased 81.01 13.77 1730 358772 275656 79108230
Myocardial infarction 80.80 13.77 494 360008 183635 79200251
Intestinal obstruction 80.76 13.77 47 360455 42973 79340913
Product prescribing error 79.90 13.77 52 360450 44761 79339125
Hypothermia 79.79 13.77 6 360496 22740 79361146
Atlantoaxial instability 79.58 13.77 35 360467 270 79383616
Synovial cyst 79.28 13.77 154 360348 9911 79373975
Hyperbilirubinaemia 79.26 13.77 9 360493 24509 79359377
Tongue disorder 79.13 13.77 187 360315 13788 79370098
Status epilepticus 78.95 13.77 10 360492 25031 79358855
Product administration error 78.80 13.77 23 360479 31823 79352063
Bursitis 78.56 13.77 346 360156 35498 79348388
Exposure during pregnancy 78.54 13.77 750 359752 100382 79283504
Mineral metabolism disorder 78.07 13.77 35 360467 284 79383602
Agranulocytosis 77.94 13.77 54 360448 44976 79338910
Epilepsy 77.62 13.77 44 360458 40816 79343070
Dementia 77.38 13.77 10 360492 24649 79359237
Lower limb fracture 77.26 13.77 256 360246 22959 79360927
Intestinal sepsis 77.06 13.77 49 360453 850 79383036
Therapy non-responder 76.94 13.77 695 359807 91610 79292276
Dystonia 76.94 13.77 5 360497 21394 79362492
Leukocytosis 76.70 13.77 51 360451 43404 79340482
X-ray abnormal 76.66 13.77 112 360390 5701 79378185
Drug use disorder 76.39 13.77 139 360363 8512 79375374
Retinitis 76.27 13.77 110 360392 5533 79378353
Blood iron abnormal 75.82 13.77 57 360445 1310 79382576
Head injury 75.77 13.77 37 360465 37332 79346554
Hospitalisation 75.61 13.77 199 360303 94037 79289849
Oxygen saturation decreased 75.60 13.77 313 360189 128734 79255152
Hepatic encephalopathy 75.35 13.77 10 360492 24156 79359730
Blood sodium decreased 75.30 13.77 28 360474 33227 79350659
Bone marrow failure 75.13 13.77 72 360430 51035 79332851
Pancreatitis 74.28 13.77 122 360380 68453 79315433
Torsade de pointes 74.20 13.77 3 360499 19309 79364577
Metastases to bone 74.07 13.77 11 360491 24416 79359470
Therapy cessation 73.46 13.77 39 360463 37523 79346363
Disseminated intravascular coagulation 73.42 13.77 35 360467 35807 79348079
Bone cyst 73.38 13.77 84 360418 3349 79380537
Sensitivity to weather change 73.23 13.77 131 360371 7916 79375970
Creatinine renal clearance decreased 72.85 13.77 3 360499 18999 79364887
Metastases to liver 72.77 13.77 19 360483 28295 79355591
Pulmonary hypertension 72.72 13.77 66 360436 48014 79335872
Lupus-like syndrome 72.65 13.77 180 360322 13677 79370209
Tachypnoea 72.59 13.77 27 360475 32036 79351850
Deep vein thrombosis postoperative 72.21 13.77 154 360348 10598 79373288
Bone disorder 72.04 13.77 220 360282 18893 79364993
Stevens-Johnson syndrome 71.82 13.77 44 360458 39122 79344764
Ankle deformity 71.69 13.77 43 360459 669 79383217
Flatulence 71.63 13.77 53 360449 42671 79341215
Muscle spasticity 71.63 13.77 237 360265 21238 79362648
Aspiration 71.63 13.77 5 360497 20153 79363733
Device dislocation 71.55 13.77 15 360487 25955 79357931
Hallucination, auditory 71.08 13.77 6 360496 20687 79363199
Hemiparesis 70.55 13.77 32 360470 33701 79350185
Adjustment disorder with depressed mood 70.32 13.77 138 360364 8948 79374938
Systemic lupus erythematosus rash 70.28 13.77 62 360440 1798 79382088
Deafness transitory 70.14 13.77 48 360454 947 79382939
Rash erythematous 70.13 13.77 95 360407 57674 79326212
Terminal state 70.06 13.77 98 360404 4791 79379095
Mitral valve incompetence 70.01 13.77 21 360481 28544 79355342
Intervertebral disc space narrowing 69.93 13.77 60 360442 1675 79382211
Mania 69.61 13.77 3 360499 18257 79365629
Colitis 69.11 13.77 142 360360 73165 79310721
Palpitations 68.74 13.77 316 360186 126294 79257592
Cholelithiasis 68.71 13.77 82 360420 52582 79331304
Thyroid neoplasm 68.61 13.77 78 360424 3086 79380800
Multiple fractures 68.40 13.77 127 360375 7899 79375987
Psoriasis 68.39 13.77 662 359840 88925 79294961
Abdominal pain lower 68.29 13.77 29 360473 31753 79352133
Facet joint syndrome 68.12 13.77 155 360347 11147 79372739
Myopathy 67.87 13.77 7 360495 20556 79363330
Hypophosphataemia 67.78 13.77 6 360496 19907 79363979
Joint dislocation 67.65 13.77 199 360303 16740 79367146
Bone density abnormal 67.32 13.77 76 360426 2984 79380902
Pollakiuria 66.94 13.77 43 360459 37274 79346612
Spinal instability 66.47 13.77 35 360467 417 79383469
Renal tubular necrosis 65.90 13.77 16 360486 25023 79358863
Drug ineffective for unapproved indication 65.56 13.77 81 360421 51157 79332729
Coordination abnormal 65.49 13.77 3 360499 17309 79366577
Muscle rigidity 65.02 13.77 7 360495 19875 79364011
Gastrooesophageal reflux disease 64.77 13.77 247 360255 103999 79279887
International normalised ratio fluctuation 64.70 13.77 79 360423 3375 79380511
Anuria 64.59 13.77 9 360493 20954 79362932
Infusion site reaction 63.99 13.77 79 360423 3414 79380472
Therapy interrupted 63.59 13.77 31 360471 31310 79352576
Electrolyte imbalance 63.49 13.77 30 360472 30851 79353035
Tinnitus 63.39 13.77 64 360438 44269 79339617
Tubulointerstitial nephritis 63.37 13.77 48 360454 38187 79345699
Muscle twitching 62.92 13.77 17 360485 24747 79359139
Extrapyramidal disorder 62.69 13.77 13 360489 22666 79361220
Haemodynamic instability 62.68 13.77 4 360498 17378 79366508
Polyarthritis 62.39 13.77 157 360345 12045 79371841
Heart rate increased 62.21 13.77 307 360195 120417 79263469
Acidosis 62.04 13.77 8 360494 19754 79364132
Wound infection 61.51 13.77 243 360259 23748 79360138
Gastritis 61.27 13.77 76 360426 47917 79335969
Toxic skin eruption 61.17 13.77 13 360489 22280 79361606
Neck deformity 61.10 13.77 57 360445 1780 79382106
Mydriasis 60.92 13.77 5 360497 17638 79366248
Lip swelling 60.88 13.77 57 360445 40854 79343032
Diarrhoea 60.75 13.77 3309 357193 877180 78506706
Atrial flutter 60.60 13.77 12 360490 21613 79362273
Visual acuity reduced 60.02 13.77 29 360473 29440 79354446
Bloody discharge 60.01 13.77 58 360444 1895 79381991
Electrocardiogram abnormal 59.91 13.77 4 360498 16733 79367153
Hepatic failure 59.91 13.77 116 360386 61096 79322790
Injection site reaction 59.44 13.77 438 360064 54347 79329539
Retinal toxicity 59.33 13.77 50 360452 1361 79382525
Cyanosis 59.07 13.77 20 360482 25162 79358724
White blood cell count increased 58.82 13.77 159 360343 74474 79309412
Onychomycosis 58.60 13.77 121 360381 8140 79375746
Diplopia 58.10 13.77 40 360462 33426 79350460
Peritonitis 58.01 13.77 27 360475 28009 79355877
Hepatic cytolysis 57.98 13.77 25 360477 27126 79356760
Spinal column injury 57.83 13.77 60 360442 2138 79381748
Device issue 57.82 13.77 25 360477 27083 79356803
Lip dry 57.67 13.77 177 360325 15241 79368645
Transfusion 57.39 13.77 13 360489 21317 79362569
Lower gastrointestinal haemorrhage 57.29 13.77 4 360498 16121 79367765
Investigation abnormal 57.26 13.77 58 360444 2008 79381878
Supraventricular tachycardia 57.15 13.77 13 360489 21257 79362629
Angina pectoris 57 13.77 91 360411 51641 79332245
Ischaemic stroke 56.98 13.77 40 360462 33091 79350795
Cellulitis 56.97 13.77 276 360226 108784 79275102
Hypercholesterolaemia 56.87 13.77 231 360271 22864 79361022
Face oedema 56.83 13.77 28 360474 28108 79355778
Aplastic anaemia 56.82 13.77 7 360495 17898 79365988
Hypophagia 56.71 13.77 73 360429 45294 79338592
Acute generalised exanthematous pustulosis 56.62 13.77 6 360496 17248 79366638
Cardiac failure acute 56.31 13.77 9 360493 18920 79364966
Mouth ulceration 56.28 13.77 331 360171 38063 79345823
Ovarian neoplasm 56.12 13.77 35 360467 586 79383300
Fear 56.04 13.77 15 360487 21971 79361915
Delusion 55.85 13.77 12 360490 20411 79363475
Left ventricular dysfunction 55.84 13.77 10 360492 19351 79364535
Drug tolerance 55.69 13.77 122 360380 8553 79375333
Nausea 55.61 13.77 3656 356846 953540 78430346
Anticipatory anxiety 55.50 13.77 45 360457 1159 79382727
Product substitution issue 55.19 13.77 12 360490 20244 79363642
Myocarditis 55.07 13.77 15 360487 21718 79362168
Gastrointestinal pain 54.85 13.77 131 360371 9724 79374162
Dactylitis 54.82 13.77 65 360437 2692 79381194
Subarachnoid haemorrhage 54.72 13.77 21 360481 24444 79359442
Acute coronary syndrome 54.66 13.77 14 360488 21119 79362767
Product quality issue 54.49 13.77 44 360458 33896 79349990
Delirium 54.21 13.77 198 360304 84429 79299457
Mycobacterium tuberculosis complex test positive 54.16 13.77 65 360437 2727 79381159
Atrioventricular block complete 53.93 13.77 6 360496 16604 79367282
Pruritus allergic 53.60 13.77 47 360455 1352 79382534
Cardiomegaly 53.57 13.77 26 360476 26326 79357560
Mental disorder 53.56 13.77 38 360464 31264 79352622
Ataxia 53.55 13.77 23 360479 25016 79358870
Asthma 53.40 13.77 374 360128 134721 79249165
Haemodialysis 53.24 13.77 9 360493 18159 79365727
Metastases to lung 53.22 13.77 9 360493 18154 79365732
Metastases to central nervous system 52.96 13.77 6 360496 16369 79367517
Renal injury 52.79 13.77 7 360495 16920 79366966
Incorrect dose administered 52.65 13.77 174 360328 76456 79307430
Malnutrition 52.56 13.77 18 360484 22484 79361402
Spinal stenosis 52.43 13.77 174 360328 15617 79368269
Body temperature increased 52.17 13.77 362 360140 44058 79339828
Prescribed overdose 51.96 13.77 321 360181 37562 79346324
Incontinence 51.85 13.77 3 360499 14161 79369725
C-reactive protein 51.79 13.77 86 360416 4893 79378993
Immune thrombocytopenia 51.78 13.77 9 360493 17796 79366090
Osteosclerosis 51.63 13.77 76 360426 3895 79379991
Hypoalbuminaemia 51.57 13.77 16 360486 21281 79362605
Hyperthyroidism 51.47 13.77 18 360484 22191 79361695
Prostate cancer 51.11 13.77 45 360457 33223 79350663
Pemphigoid 51.10 13.77 5 360497 15310 79368576
Vertigo 50.88 13.77 152 360350 68930 79314956
Shock haemorrhagic 50.54 13.77 14 360488 20046 79363840
Urine output decreased 50.50 13.77 10 360492 18012 79365874
Joint space narrowing 50.43 13.77 34 360468 654 79383232
Blood glucose decreased 50.19 13.77 28 360474 26206 79357680
Fear of injection 50.14 13.77 107 360395 7367 79376519
Localised infection 50.05 13.77 316 360186 37259 79346627
Clostridium difficile infection 50.01 13.77 72 360430 42613 79341273
Weight decreased 49.95 13.77 1223 359279 353975 79029911
Maternal exposure timing unspecified 49.80 13.77 92 360410 5700 79378186
Nocturia 49.78 13.77 3 360499 13678 79370208
Sudden death 49.24 13.77 20 360482 22491 79361395
Speech disorder 49.19 13.77 108 360394 54337 79329549
Ventricular extrasystoles 49.18 13.77 14 360488 19690 79364196
Arthritis bacterial 49.04 13.77 120 360382 9046 79374840
Peripheral venous disease 49.04 13.77 171 360331 15738 79368148
Nail disorder 49.02 13.77 141 360361 11711 79372175
Haemorrhoids 49.01 13.77 36 360466 29092 79354794
Red cell distribution width decreased 48.95 13.77 53 360449 1985 79381901
Extremity contracture 48.69 13.77 49 360453 1683 79382203
Device difficult to use 48.50 13.77 3 360499 13382 79370504
Tuberculosis 48.28 13.77 165 360337 15033 79368853
Emotional distress 48.24 13.77 66 360436 39903 79343983
Acute respiratory distress syndrome 48.10 13.77 78 360424 43989 79339897
Pulmonary toxicity 48.07 13.77 148 360354 12766 79371120
Cytomegalovirus infection 47.95 13.77 74 360428 42570 79341316
Chondropathy 47.94 13.77 58 360444 2454 79381432
Polyomavirus-associated nephropathy 47.91 13.77 89 360413 5538 79378348
Frequent bowel movements 47.79 13.77 38 360464 29501 79354385
Nightmare 47.49 13.77 29 360473 25832 79358054
Bronchitis chronic 47.41 13.77 78 360424 4404 79379482
Device related infection 47.35 13.77 51 360451 34243 79349643
Blood magnesium decreased 46.61 13.77 9 360493 16503 79367383
Appendicitis 46.26 13.77 18 360484 20776 79363110
Vascular access complication 45.98 13.77 53 360449 2129 79381757
Oliguria 45.81 13.77 9 360493 16300 79367586
Arteriosclerosis coronary artery 45.70 13.77 12 360490 17804 79366082
Jaundice 45.64 13.77 109 360393 53240 79330646
Myelodysplastic syndrome 45.34 13.77 42 360460 30259 79353627
Secretion discharge 45.04 13.77 160 360342 14862 79369024
Confusional state 44.95 13.77 1094 359408 316903 79066983
Coagulopathy 44.94 13.77 58 360444 35948 79347938
Mean platelet volume decreased 44.64 13.77 59 360443 2731 79381155
Mycotic allergy 44.60 13.77 44 360458 1475 79382411
Skin exfoliation 44.47 13.77 116 360386 54984 79328902
Ankle arthroplasty 44.45 13.77 44 360458 1481 79382405
Myelosuppression 44.29 13.77 71 360431 40225 79343661
Vasculitic rash 44.27 13.77 52 360450 2132 79381754
Colitis ischaemic 44.15 13.77 8 360494 15351 79368535
Fracture delayed union 44.04 13.77 51 360451 2059 79381827
Troponin increased 43.95 13.77 16 360486 19239 79364647
Rash maculo-papular 43.79 13.77 120 360382 55958 79327928
Hair follicle tumour benign 43.77 13.77 27 360475 443 79383443
Gait disturbance 43.65 13.77 1238 359264 206268 79177618
Myocardial ischaemia 43.64 13.77 31 360471 25488 79358398
Erectile dysfunction 43.56 13.77 7 360495 14657 79369229
Hypotonia 43.48 13.77 4 360498 12866 79371020
Paraesthesia oral 43.47 13.77 19 360483 20452 79363434
Panic attack 43.31 13.77 28 360474 24188 79359698
Sleep apnoea syndrome 43.26 13.77 61 360441 36417 79347469
Pulmonary thrombosis 43.01 13.77 137 360365 12034 79371852
Lacrimation increased 42.99 13.77 24 360478 22453 79361433
Wrist surgery 42.96 13.77 33 360469 784 79383102
Faeces discoloured 42.85 13.77 41 360461 29086 79354800
Accidental exposure to product 42.78 13.77 47 360455 31275 79352611
Lymphopenia 42.68 13.77 45 360457 30512 79353374
Inappropriate schedule of product administration 42.63 13.77 392 360110 133236 79250650
Blood loss anaemia 42.60 13.77 9 360493 15489 79368397
Neutrophil count increased 42.52 13.77 42 360460 29354 79354532
Hepatocellular injury 42.51 13.77 95 360407 47498 79336388
Drug level decreased 42.50 13.77 7 360495 14395 79369491
Bronchopulmonary aspergillosis 42.36 13.77 24 360478 22270 79361616
Oesophagitis 42.20 13.77 29 360473 24260 79359626
Skin discolouration 41.70 13.77 76 360426 40958 79342928
Granuloma 41.64 13.77 106 360396 8191 79375695
Pulmonary haemorrhage 41.59 13.77 8 360494 14709 79369177
Infusion site pain 41.59 13.77 7 360495 14169 79369717
Autoimmune disorder 41.58 13.77 167 360335 16445 79367441
Eosinophil count increased 41.15 13.77 13 360489 17092 79366794
Atrioventricular block 41.05 13.77 7 360495 14034 79369852
Injection site hypersensitivity 40.97 13.77 47 360455 1878 79382008
Angina unstable 40.77 13.77 12 360490 16515 79367371
Hepatotoxicity 40.43 13.77 382 360120 50970 79332916
Prothrombin time prolonged 40.38 13.77 13 360489 16886 79367000
Emotional disorder 40.28 13.77 8 360494 14379 79369507
Thirst 39.98 13.77 17 360485 18602 79365284
Incorrect product administration duration 39.92 13.77 4 360498 12018 79371868
Mental impairment 39.90 13.77 18 360484 19018 79364868
Osteoporotic fracture 39.84 13.77 70 360432 4170 79379716
Live birth 39.61 13.77 179 360323 18565 79365321
Paraesthesia 39.48 13.77 560 359942 175763 79208123
Chromaturia 39.34 13.77 35 360467 25711 79358175
Vaginal haemorrhage 39.32 13.77 25 360477 21792 79362094
Cholecystitis 39.29 13.77 26 360476 22186 79361700
Tricuspid valve incompetence 39.24 13.77 20 360482 19692 79364194
Pneumonia fungal 39.20 13.77 3 360499 11207 79372679
Failure to thrive 39.17 13.77 4 360498 11840 79372046
Cardiomyopathy 38.40 13.77 44 360458 28730 79355156
Feeling abnormal 38.39 13.77 498 360004 158701 79225185
Burning sensation 38.33 13.77 136 360366 58496 79325390
Mean cell volume decreased 38.12 13.77 75 360427 4872 79379014
Respiratory disorder 38.01 13.77 339 360163 44517 79339369
Liver disorder 37.90 13.77 497 360005 71920 79311966
Dialysis 37.86 13.77 18 360484 18444 79365442
Joint ankylosis 37.85 13.77 48 360454 2132 79381754
Dysphonia 37.79 13.77 131 360371 56741 79327145
Lyme disease 37.75 13.77 60 360442 3290 79380596
Soft tissue swelling 37.75 13.77 40 360462 1461 79382425
Cytology abnormal 37.73 13.77 22 360480 324 79383562
Demyelination 37.69 13.77 100 360402 7923 79375963
Acute pulmonary oedema 37.63 13.77 9 360493 14221 79369665
Diastolic dysfunction 37.51 13.77 3 360499 10808 79373078
Allergic oedema 37.39 13.77 30 360472 761 79383125
Foot fracture 37.20 13.77 197 360305 21784 79362102
Transaminases abnormal 37.19 13.77 31 360471 831 79383055
Pulmonary arterial hypertension 37.18 13.77 44 360458 28322 79355564
Coronary artery stenosis 36.99 13.77 6 360496 12478 79371408
Bradyphrenia 36.78 13.77 3 360499 10637 79373249
Hypertension 36.71 13.77 1839 358663 329153 79054733
Brain oedema 36.65 13.77 36 360466 25227 79358659
Mass excision 36.64 13.77 22 360480 343 79383543
Labile blood pressure 36.60 13.77 48 360454 2205 79381681
Bronchospasm 36.56 13.77 35 360467 24824 79359062
Respiratory acidosis 36.48 13.77 4 360498 11196 79372690
Epstein-Barr virus infection 36.43 13.77 10 360492 14406 79369480
Atelectasis 36.24 13.77 56 360446 32201 79351685
Infiltration anaesthesia 36.03 13.77 17 360485 157 79383729
Hypercalcaemia 36.01 13.77 297 360205 38133 79345753
Klebsiella infection 35.99 13.77 13 360489 15707 79368179
Diabetes mellitus inadequate control 35.87 13.77 34 360468 24230 79359656
Activated partial thromboplastin time prolonged 35.71 13.77 10 360492 14218 79369668
Bladder cancer 35.71 13.77 22 360480 19504 79364382
Salivary hypersecretion 35.70 13.77 10 360492 14214 79369672
Herpes zoster 35.50 13.77 605 359897 92478 79291408
Ear infection 35.49 13.77 272 360230 34160 79349726
Hospice care 35.44 13.77 3 360499 10321 79373565
Anal incontinence 35.32 13.77 19 360483 18149 79365737
Epistaxis 35.19 13.77 328 360174 111187 79272699
Pustular psoriasis 34.80 13.77 71 360431 4735 79379151
Eye swelling 34.75 13.77 41 360461 26427 79357459
Pulse absent 34.51 13.77 3 360499 10100 79373786
Aspergillus infection 34.48 13.77 22 360480 19139 79364747
Complication associated with device 34.46 13.77 18 360484 17478 79366408
Impaired gastric emptying 34.30 13.77 114 360388 10239 79373647
Hiccups 34.20 13.77 3 360499 10028 79373858
Osteopenia 34.16 13.77 169 360333 18195 79365691
Proteinuria 34.11 13.77 59 360443 32443 79351443
Spinal fusion surgery 34.00 13.77 74 360428 5164 79378722
Cutaneous vasculitis 33.96 13.77 98 360404 8154 79375732
Asphyxia 33.92 13.77 6 360496 11714 79372172
Hepatic cancer 33.70 13.77 4 360498 10525 79373361
Skin papilloma 33.58 13.77 79 360423 5807 79378079
Oropharyngeal pain 33.50 13.77 324 360178 109029 79274857
Enteritis 33.49 13.77 12 360490 14571 79369315
Polyuria 33.39 13.77 13 360489 15001 79368885
Sarcoidosis 33.36 13.77 98 360404 8237 79375649
Enterocolitis 33.22 13.77 12 360490 14500 79369386
Hypermobility syndrome 33.22 13.77 24 360478 518 79383368
Posterior reversible encephalopathy syndrome 33.14 13.77 42 360460 26239 79357647
Purpura 33.02 13.77 24 360478 19503 79364383
Embolism 32.98 13.77 11 360491 13971 79369915
Enthesophyte 32.81 13.77 12 360490 53 79383833
Apathy 32.80 13.77 9 360493 12968 79370918
Eye pain 32.76 13.77 76 360426 37502 79346384
Heparin-induced thrombocytopenia 32.73 13.77 3 360499 9679 79374207
Hypothyroidism 32.62 13.77 124 360378 52268 79331618
Hyperlipidaemia 32.60 13.77 42 360460 26051 79357835
Swollen tongue 32.56 13.77 92 360410 42478 79341408
Bunion operation 32.56 13.77 30 360472 922 79382964
Ileus paralytic 32.47 13.77 3 360499 9617 79374269
Neck pain 32.43 13.77 500 360002 74917 79308969
General physical health deterioration 32.34 13.77 1538 358964 273700 79110186
Tooth disorder 32.12 13.77 216 360286 26017 79357869
Rash papular 32.06 13.77 31 360471 21885 79362001
Sensory disturbance 32.00 13.77 14 360488 15063 79368823
Feeling hot 31.87 13.77 150 360352 59584 79324302
Respiratory syncytial virus infection 31.55 13.77 3 360499 9399 79374487
Tardive dyskinesia 31.50 13.77 5 360497 10566 79373320
Productive cough 31.35 13.77 252 360250 88079 79295807
Joint lock 31.29 13.77 54 360448 3171 79380715
Blindness 31.20 13.77 50 360452 28333 79355553
Tendon disorder 31.19 13.77 87 360415 7099 79376787
Latent tuberculosis 31.05 13.77 55 360447 3298 79380588
Brain injury 31.02 13.77 7 360495 11510 79372376
Bundle branch block left 31.01 13.77 7 360495 11506 79372380
Hepatitis cholestatic 30.80 13.77 12 360490 13840 79370046
Psychomotor hyperactivity 30.79 13.77 19 360483 16830 79367056
Swelling face 30.72 13.77 192 360310 71020 79312866
Central nervous system lesion 30.70 13.77 11 360491 13357 79370529
Eructation 30.68 13.77 6 360496 10903 79372983
Abnormal dreams 30.61 13.77 7 360495 11405 79372481
Abdominal pain upper 30.54 13.77 1270 359232 222549 79161337
Vascular device infection 30.31 13.77 5 360497 10271 79373615
Pseudomonas infection 30.08 13.77 30 360472 20873 79363013
Hypersomnia 30.05 13.77 36 360466 23050 79360836
Bundle branch block right 29.98 13.77 7 360495 11244 79372642
Personality change 29.89 13.77 5 360497 10165 79373721
Rash macular 29.84 13.77 53 360449 28846 79355040
Cerebral ischaemia 29.76 13.77 7 360495 11188 79372698
COVID-19 pneumonia 29.70 13.77 53 360449 28796 79355090
Colitis ulcerative 29.70 13.77 71 360431 34671 79349215
Abortion spontaneous 29.67 13.77 55 360447 29452 79354434
Glycosylated haemoglobin increased 29.65 13.77 26 360476 19234 79364652
Enterococcal infection 29.55 13.77 17 360485 15643 79368243
Benign prostatic hyperplasia 29.45 13.77 8 360494 11604 79372282
Laryngitis 29.41 13.77 147 360355 15892 79367994
Escherichia infection 29.37 13.77 23 360479 17994 79365892
Colitis microscopic 29.18 13.77 111 360391 10657 79373229
Pulmonary mass 29.17 13.77 228 360274 28806 79355080
Carpal tunnel syndrome 29.04 13.77 169 360333 19359 79364527
Thrombotic microangiopathy 28.96 13.77 29 360473 20140 79363746
Rash pruritic 28.95 13.77 470 360032 71159 79312727
Retching 28.85 13.77 22 360480 17445 79366441
Neoplasm malignant 28.83 13.77 244 360258 31566 79352320
Pulseless electrical activity 28.74 13.77 14 360488 14146 79369740
Walking aid user 28.66 13.77 106 360396 10042 79373844
Hepatic cirrhosis 28.65 13.77 262 360240 34644 79349242
Nephropathy toxic 28.60 13.77 30 360472 20389 79363497
Hemiplegia 28.50 13.77 16 360486 14923 79368963
Device leakage 28.45 13.77 7 360495 10849 79373037
Hypovolaemic shock 28.36 13.77 10 360492 12266 79371620
Drug level below therapeutic 28.28 13.77 5 360497 9765 79374121
Muscular weakness 28.19 13.77 534 359968 160195 79223691
Hyperthermia 28.19 13.77 24 360478 18013 79365873
Cystitis haemorrhagic 28.11 13.77 4 360498 9168 79374718
Apnoea 27.97 13.77 9 360493 11695 79372191
Soft tissue disorder 27.95 13.77 54 360448 3461 79380425
Skin reaction 27.88 13.77 145 360357 15923 79367963
Exercise tolerance decreased 27.70 13.77 4 360498 9067 79374819
Osteomyelitis 27.65 13.77 248 360254 32617 79351269
Depression 27.63 13.77 757 359745 216033 79167853
Hepatocellular carcinoma 27.50 13.77 4 360498 9017 79374869
Nail psoriasis 27.42 13.77 23 360479 622 79383264
Tender joint count 27.42 13.77 15 360487 194 79383692
Underdose 27.36 13.77 69 360433 33082 79350804
Loss of employment 27.33 13.77 45 360457 2542 79381344
Respiratory tract infection 27.33 13.77 120 360382 48569 79335317
Premature labour 27.32 13.77 3 360499 8387 79375499
Hepatomegaly 27.26 13.77 27 360475 18847 79365039
Osteonecrosis of jaw 27.11 13.77 102 360400 43124 79340762
Brain natriuretic peptide increased 27.00 13.77 4 360498 8896 79374990
Acute hepatic failure 26.98 13.77 60 360442 30053 79353833
Cholangitis 26.90 13.77 12 360490 12764 79371122
Multiple allergies 26.86 13.77 106 360396 10354 79373532
Hypertriglyceridaemia 26.78 13.77 12 360490 12728 79371158
Knee deformity 26.72 13.77 31 360471 1254 79382632
Mean cell haemoglobin decreased 26.67 13.77 75 360427 6149 79377737
Renal disorder 26.64 13.77 99 360403 42006 79341880
Prostatic specific antigen increased 26.63 13.77 7 360495 10379 79373507
Impaired quality of life 26.60 13.77 16 360486 14370 79369516
Neurological symptom 26.53 13.77 4 360498 8779 79375107
Bacterial sepsis 26.52 13.77 3 360499 8195 79375691
Jaundice cholestatic 26.40 13.77 9 360493 11275 79372611
Diffuse large B-cell lymphoma 26.24 13.77 11 360491 12138 79371748
Disease susceptibility 26.19 13.77 17 360485 306 79383580
Haematocrit decreased 26.09 13.77 166 360336 61146 79322740
Bedridden 26.01 13.77 116 360386 11963 79371923
Middle lobe syndrome 25.92 13.77 9 360493 33 79383853
Myositis 25.91 13.77 29 360473 19139 79364747
Gout 25.90 13.77 45 360457 24704 79359182
Bacterial infection 25.89 13.77 65 360437 31215 79352671
Large intestine perforation 25.84 13.77 17 360485 14550 79369336
Hepatic fibrosis 25.77 13.77 82 360420 7198 79376688
Hepatitis 25.72 13.77 374 360128 55353 79328533
Blood potassium increased 25.69 13.77 59 360443 29216 79354670
Neuralgia 25.64 13.77 72 360430 33312 79350574
Abscess 25.64 13.77 40 360462 22911 79360975
Lipase increased 25.63 13.77 22 360480 16444 79367442
Localised oedema 25.50 13.77 3 360499 7949 79375937
Pregnancy 25.42 13.77 208 360294 26643 79357243
Peritonitis bacterial 25.40 13.77 6 360496 9561 79374325
Rheumatoid factor 25.34 13.77 18 360484 378 79383508
Nervous system disorder 25.32 13.77 52 360450 26804 79357082
Pyelonephritis 25.28 13.77 33 360469 20355 79363531
Haemolytic anaemia 25.16 13.77 26 360476 17794 79366092
Extra dose administered 25.03 13.77 4 360498 8411 79375475
Neck mass 25.01 13.77 59 360443 4345 79379541
Hyperuricaemia 24.98 13.77 11 360491 11788 79372098
Hypercapnia 24.95 13.77 5 360497 8930 79374956
Peripheral sensory neuropathy 24.80 13.77 14 360488 13019 79370867
Nystagmus 24.79 13.77 7 360495 9897 79373989
Injection site pain 24.78 13.77 425 360077 129413 79254473
Azotaemia 24.47 13.77 4 360498 8272 79375614
Carotid artery stenosis 24.25 13.77 5 360497 8753 79375133
Steatohepatitis 24.22 13.77 26 360476 964 79382922
Immobile 24.19 13.77 78 360424 6895 79376991
Procedural pain 24.14 13.77 42 360460 23042 79360844
Juvenile idiopathic arthritis 24.06 13.77 61 360441 4702 79379184
Therapeutic response unexpected 24.00 13.77 33 360469 19913 79363973
Blood pressure systolic decreased 23.97 13.77 10 360492 11066 79372820
Hepatitis acute 23.90 13.77 21 360481 15521 79368365
Throat tightness 23.88 13.77 57 360445 27850 79356036
Progressive multifocal leukoencephalopathy 23.88 13.77 35 360467 20565 79363321
Metabolic disorder 23.86 13.77 6 360496 9164 79374722
Thinking abnormal 23.83 13.77 15 360487 13146 79370740
Petechiae 23.78 13.77 35 360467 20530 79363356
Cerebral atrophy 23.66 13.77 4 360498 8071 79375815
Left ventricular failure 23.56 13.77 7 360495 9574 79374312
Gastric haemorrhage 23.55 13.77 20 360482 15030 79368856
Cold sweat 23.46 13.77 30 360472 18669 79365217
Restless legs syndrome 23.43 13.77 34 360468 20058 79363828
Chronic sinusitis 23.38 13.77 15 360487 13011 79370875
Congestive cardiomyopathy 23.37 13.77 12 360490 11768 79372118
Device malfunction 23.37 13.77 38 360464 21410 79362476
Rheumatic disorder 23.28 13.77 47 360455 3111 79380775
Sensory loss 23.26 13.77 15 360487 12976 79370910
Coronary artery occlusion 23.19 13.77 21 360481 15294 79368592
Refusal of treatment by patient 23.17 13.77 6 360496 8985 79374901
Urticarial vasculitis 23.14 13.77 20 360482 564 79383322
Cerebral haematoma 23.13 13.77 4 360498 7938 79375948
Food allergy 23.06 13.77 10 360492 10814 79373072
Eye disorder 23.05 13.77 183 360319 23229 79360657
Muscle tightness 23.00 13.77 15 360487 12899 79370987
Hiatus hernia 22.96 13.77 44 360458 23268 79360618
Blood culture positive 22.95 13.77 5 360497 8424 79375462
Musculoskeletal discomfort 22.91 13.77 161 360341 19674 79364212
Pneumonia viral 22.87 13.77 92 360410 9066 79374820
Product monitoring error 22.84 13.77 6 360496 8900 79374986
Feeling cold 22.78 13.77 61 360441 28668 79355218
Erythema 22.77 13.77 803 359699 222487 79161399
Smear cervix abnormal 22.71 13.77 41 360461 2495 79381391
Ventricular arrhythmia 22.59 13.77 6 360496 8834 79375052
Transplant rejection 22.56 13.77 33 360469 19404 79364482
Hypertonia 22.53 13.77 3 360499 7229 79376657
Potentiating drug interaction 22.51 13.77 6 360496 8813 79375073
Overwork 22.50 13.77 9 360493 53 79383833
Erythema multiforme 22.48 13.77 28 360474 17623 79366263
Cardiac tamponade 22.41 13.77 7 360495 9269 79374617
Generalised oedema 22.28 13.77 46 360456 23663 79360223
Duodenal ulcer haemorrhage 22.25 13.77 3 360499 7160 79376726
Staphylococcal infection 22.24 13.77 163 360339 58132 79325754
Glomerular filtration rate decreased 22.23 13.77 43 360459 22659 79361227
Rhinitis allergic 22.19 13.77 14 360488 12255 79371631
Sinus node dysfunction 22.16 13.77 4 360498 7697 79376189
Diabetic eye disease 22.08 13.77 12 360490 153 79383733
Allergy to chemicals 21.96 13.77 41 360461 2561 79381325
Pulmonary function test decreased 21.90 13.77 4 360498 7633 79376253
Caesarean section 21.73 13.77 15 360487 12520 79371366
Dermatitis acneiform 21.66 13.77 9 360493 9984 79373902
Eyelid oedema 21.65 13.77 18 360484 13669 79370217
Mean cell haemoglobin concentration abnormal 21.62 13.77 12 360490 160 79383726
Immunosuppressant drug level increased 21.47 13.77 7 360495 9020 79374866
Inflammatory pain 21.46 13.77 25 360477 1016 79382870
Lupus vulgaris 21.41 13.77 47 360455 3299 79380587
Haemolysis 21.34 13.77 16 360486 12796 79371090
Paralysis 21.26 13.77 17 360485 13160 79370726
Food intolerance 21.25 13.77 51 360451 3797 79380089
Muscle relaxant therapy 21.23 13.77 12 360490 166 79383720
Brain herniation 21.21 13.77 4 360498 7459 79376427
Cardiac failure chronic 21.13 13.77 12 360490 11123 79372763
Metastasis 21.09 13.77 3 360499 6877 79377009
Eye pruritus 20.99 13.77 38 360464 20532 79363354
Product label confusion 20.97 13.77 31 360471 1595 79382291
Therapy change 20.96 13.77 4 360498 7395 79376491
Spinal meningioma benign 20.86 13.77 10 360492 96 79383790
Eyelid ptosis 20.82 13.77 12 360490 11032 79372854
Inflammatory marker increased 20.81 13.77 100 360402 10640 79373246
Tenderness 20.71 13.77 180 360322 23462 79360424
Limb operation 20.66 13.77 47 360455 3379 79380507
Embolic stroke 20.60 13.77 5 360497 7821 79376065
Facial paralysis 20.56 13.77 40 360462 21032 79362854
Aplasia pure red cell 20.54 13.77 5 360497 7805 79376081
Onychomadesis 20.38 13.77 61 360441 5181 79378705
Pneumothorax 20.37 13.77 63 360439 28260 79355626
Blood albumin decreased 20.36 13.77 50 360452 24193 79359693
Glaucoma 20.31 13.77 156 360346 19605 79364281
Thrombosis 20.29 13.77 263 360239 83837 79300049
Hepatic steatosis 20.16 13.77 260 360242 37478 79346408
Arteriosclerosis 20.14 13.77 32 360470 18195 79365691
Hepatic ischaemia 20.08 13.77 25 360477 1090 79382796
Hepatic necrosis 20.04 13.77 8 360494 9092 79374794
Mood altered 20.03 13.77 31 360471 17816 79366070
Concomitant disease aggravated 20.00 13.77 18 360484 13149 79370737
Aortic valve incompetence 19.99 13.77 9 360493 9521 79374365
Amylase increased 19.99 13.77 13 360489 11196 79372690
Increased appetite 19.90 13.77 15 360487 11963 79371923
Breast cancer metastatic 19.89 13.77 7 360495 8595 79375291
Blood lactic acid increased 19.87 13.77 17 360485 12727 79371159
Ammonia increased 19.86 13.77 5 360497 7630 79376256
Decubitus ulcer 19.85 13.77 25 360477 15662 79368224
Wheelchair user 19.85 13.77 67 360435 6065 79377821
Tongue oedema 19.84 13.77 4 360498 7113 79376773
Hepatitis C 19.72 13.77 15 360487 11910 79371976
Cholecystitis acute 19.71 13.77 19 360483 13432 79370454
Neck surgery 19.71 13.77 32 360470 1787 79382099
Viral upper respiratory tract infection 19.68 13.77 87 360415 8939 79374947
Hip fracture 19.67 13.77 72 360430 30689 79353197
Alanine aminotransferase increased 19.63 13.77 911 359591 161659 79222227
Colon cancer 19.60 13.77 22 360480 14501 79369385
Nervousness 19.59 13.77 81 360421 33334 79350552
Device occlusion 19.53 13.77 15 360487 11851 79372035
Rib fracture 19.51 13.77 63 360439 27884 79356002
Spinal disorder 19.50 13.77 95 360407 10165 79373721
Renal tubular disorder 19.48 13.77 3 360499 6483 79377403
Pulmonary alveolar haemorrhage 19.48 13.77 14 360488 11443 79372443
Lung infiltration 19.45 13.77 47 360455 22865 79361021
Eye movement disorder 19.43 13.77 6 360496 8005 79375881
Supraventricular extrasystoles 19.32 13.77 4 360498 6983 79376903
Hydrocephalus 19.31 13.77 8 360494 8892 79374994
Heart rate irregular 19.29 13.77 79 360423 32600 79351286
Squamous cell carcinoma of skin 19.23 13.77 21 360481 14012 79369874
Pleural thickening 19.21 13.77 42 360460 2940 79380946
Ventricular hypertrophy 19.13 13.77 4 360498 6934 79376952
Unevaluable event 19.07 13.77 160 360342 55425 79328461
Viral infection 19.06 13.77 115 360387 42901 79340985
Memory impairment 19.04 13.77 373 360129 111361 79272525
Hyperphosphataemia 19.04 13.77 3 360499 6373 79377513
Extrasystoles 19.02 13.77 5 360497 7414 79376472
Hyperventilation 19.01 13.77 6 360496 7893 79375993
Presbyacusis 18.91 13.77 39 360463 2621 79381265
Bowel movement irregularity 18.87 13.77 3 360499 6331 79377555
Hot flush 18.81 13.77 158 360344 54719 79329167
Gastritis erosive 18.78 13.77 13 360489 10834 79373052
Lung disorder 18.73 13.77 487 360015 80070 79303816
Forced expiratory volume decreased 18.69 13.77 6 360496 7808 79376078
Peripheral coldness 18.64 13.77 27 360475 15943 79367943
Pleural fibrosis 18.63 13.77 51 360451 4116 79379770
Post procedural complication 18.59 13.77 51 360451 23778 79360108
Haemorrhoidal haemorrhage 18.57 13.77 4 360498 6791 79377095
Ageusia 18.56 13.77 29 360473 16603 79367283
Retinal haemorrhage 18.47 13.77 7 360495 8210 79375676
Tender joint count increased 18.46 13.77 13 360489 269 79383617
Vitreous floaters 18.40 13.77 5 360497 7251 79376635
Swollen joint count 18.38 13.77 25 360477 1190 79382696
Sebaceous gland infection 18.35 13.77 11 360491 171 79383715
No adverse event 18.34 13.77 96 360406 37096 79346790
Dry throat 18.28 13.77 6 360496 7700 79376186
Amenorrhoea 18.23 13.77 6 360496 7686 79376200
Prescribed underdose 18.23 13.77 209 360293 29305 79354581
Gastric ulcer haemorrhage 18.21 13.77 9 360493 9018 79374868
Intervertebral disc degeneration 18.15 13.77 128 360374 15657 79368229
Dermatitis contact 18.09 13.77 14 360488 11019 79372867
Blood phosphorus decreased 18.07 13.77 4 360498 6664 79377222
Ocular hyperaemia 18.05 13.77 66 360436 28140 79355746
Blood triglycerides increased 17.98 13.77 43 360459 20997 79362889
Nerve block 17.93 13.77 19 360483 694 79383192
Hyperpyrexia 17.89 13.77 3 360499 6089 79377797
Rotator cuff syndrome 17.82 13.77 117 360385 13978 79369908
Oral discomfort 17.57 13.77 89 360413 9671 79374215
Urine analysis abnormal 17.49 13.77 4 360498 6516 79377370
Elbow operation 17.45 13.77 14 360488 355 79383531
Muscle spasms 17.44 13.77 630 359872 174100 79209786
Large intestine polyp 17.43 13.77 19 360483 12689 79371197
Left ventricular hypertrophy 17.36 13.77 15 360487 11176 79372710
Metastases to lymph nodes 17.30 13.77 13 360489 10384 79373502
Micturition urgency 17.23 13.77 19 360483 12622 79371264
Multiple sclerosis 17.16 13.77 48 360454 22234 79361652
Drug level above therapeutic 17.14 13.77 9 360493 8714 79375172
Feeding disorder 17.09 13.77 129 360373 16125 79367761
Peripheral arterial occlusive disease 17.01 13.77 8 360494 8250 79375636
Urosepsis 16.96 13.77 62 360440 26433 79357453
Spinal cord compression 16.93 13.77 4 360498 6373 79377513
Pneumonia bacterial 16.93 13.77 39 360463 19292 79364594
Fibrin D dimer increased 16.90 13.77 9 360493 8645 79375241
Haemorrhagic stroke 16.90 13.77 15 360487 11031 79372855
Weber tuning fork test abnormal 16.89 13.77 9 360493 110 79383776
Graft versus host disease in gastrointestinal tract 16.85 13.77 4 360498 6352 79377534
Intervertebral disc compression 16.84 13.77 25 360477 1291 79382595
Pancreatic carcinoma 16.81 13.77 22 360480 13555 79370331
Haemarthrosis 16.77 13.77 3 360499 5809 79378077
Oral disorder 16.76 13.77 90 360412 10005 79373881
Coeliac disease 16.72 13.77 98 360404 11253 79372633
Pyopneumothorax 16.67 13.77 8 360494 77 79383809
Influenza like illness 16.66 13.77 226 360276 71481 79312405
Malignant neoplasm of conjunctiva 16.61 13.77 7 360495 48 79383838
Incoherent 16.55 13.77 7 360495 7685 79376201
Gangrene 16.53 13.77 10 360492 8954 79374932
Rebound effect 16.50 13.77 6 360496 7220 79376666
Head discomfort 16.46 13.77 25 360477 14477 79369409
Petit mal epilepsy 16.43 13.77 3 360499 5724 79378162
Device related sepsis 16.40 13.77 4 360498 6236 79377650
Hypoaesthesia oral 16.37 13.77 24 360478 14100 79369786
Infusion site extravasation 16.36 13.77 13 360489 10095 79373791
Tooth infection 16.30 13.77 143 360359 18689 79365197
Clear cell renal cell carcinoma 16.28 13.77 36 360466 2540 79381346
Gastroenteritis 16.24 13.77 89 360413 33993 79349893
Dermatitis exfoliative 16.21 13.77 15 360487 10814 79373072
Cartilage atrophy 16.21 13.77 10 360492 164 79383722
Intestinal perforation 16.21 13.77 34 360468 17392 79366494
Blood uric acid increased 16.18 13.77 22 360480 13338 79370548
Adenovirus infection 16.18 13.77 9 360493 8438 79375448
Pseudomonal sepsis 16.14 13.77 4 360498 6170 79377716
Abnormal faeces 16.12 13.77 7 360495 7564 79376322
Arthritis infective 16.02 13.77 77 360425 8194 79375692
Gastrointestinal perforation 16.00 13.77 4 360498 6133 79377753
Normal newborn 15.93 13.77 6 360496 7066 79376820
Systemic inflammatory response syndrome 15.88 13.77 17 360485 11448 79372438
Endocrine ophthalmopathy 15.88 13.77 18 360484 710 79383176
Hyperammonaemia 15.87 13.77 16 360486 11077 79372809
Leukoencephalopathy 15.85 13.77 8 360494 7921 79375965
Cachexia 15.84 13.77 16 360486 11067 79372819
Polyneuropathy 15.80 13.77 56 360446 24095 79359791
Snoring 15.78 13.77 3 360499 5563 79378323
Nasal congestion 15.78 13.77 247 360255 76305 79307581
Gastrointestinal necrosis 15.78 13.77 3 360499 5562 79378324
Injury 15.63 13.77 460 360042 77036 79306850
Pyelonephritis acute 15.56 13.77 4 360498 6019 79377867
Ossicle disorder 15.49 13.77 6 360496 32 79383854
Drug effective for unapproved indication 15.47 13.77 4 360498 5997 79377889
Anal fistula 15.46 13.77 6 360496 6938 79376948
Vaginal haematoma 15.41 13.77 9 360493 133 79383753
Respiration abnormal 15.35 13.77 8 360494 7780 79376106
Sexual dysfunction 15.27 13.77 8 360494 7755 79376131
Major depression 15.23 13.77 11 360491 8969 79374917
Skin irritation 15.20 13.77 17 360485 11223 79372663
Nail operation 15.19 13.77 17 360485 661 79383225
Drug specific antibody present 15.18 13.77 65 360437 6587 79377299
Cataract 15.17 13.77 378 360124 61742 79322144
Elbow deformity 15.14 13.77 26 360476 1521 79382365
Thrombotic thrombocytopenic purpura 15.07 13.77 5 360497 6371 79377515
Splenomegaly 15.04 13.77 46 360456 20708 79363178
Pseudomembranous colitis 15.02 13.77 3 360499 5371 79378515
Ureaplasma infection 14.98 13.77 21 360481 1029 79382857
Back injury 14.96 13.77 90 360412 10433 79373453
Stress at work 14.92 13.77 22 360480 1129 79382757
Staphylococcal bacteraemia 14.92 13.77 20 360482 12198 79371688
Myasthenia gravis 14.88 13.77 15 360487 10384 79373502
Functional gastrointestinal disorder 14.83 13.77 53 360449 4937 79378949
Gestational diabetes 14.76 13.77 5 360497 6288 79377598
Haemophagocytic lymphohistiocytosis 14.71 13.77 50 360452 21787 79362099
CD4/CD8 ratio increased 14.69 13.77 5 360497 17 79383869
Systemic candida 14.60 13.77 6 360496 6700 79377186
Drug dose omission by device 14.60 13.77 5 360497 6245 79377641
Mycobacterium marinum infection 14.55 13.77 14 360488 455 79383431
Anaphylactic shock 14.53 13.77 99 360403 35897 79347989
Respiratory rate decreased 14.50 13.77 3 360499 5240 79378646
Neutrophilia 14.48 13.77 9 360493 7942 79375944
Optic neuritis 14.48 13.77 13 360489 9507 79374379
Portal hypertension 14.47 13.77 7 360495 7101 79376785
Sudden cardiac death 14.43 13.77 3 360499 5222 79378664
Splenic embolism 14.41 13.77 10 360492 202 79383684
Kidney transplant rejection 14.41 13.77 15 360487 10231 79373655
Cardiac granuloma 14.39 13.77 4 360498 5 79383881
Cytomegalovirus infection reactivation 14.37 13.77 11 360491 8705 79375181
Flank pain 14.37 13.77 44 360458 19800 79364086
Pharyngeal oedema 14.31 13.77 124 360378 16148 79367738
Laryngeal disorder 14.28 13.77 21 360481 1075 79382811
Expired product administered 14.27 13.77 7 360495 7044 79376842
Cytopenia 14.19 13.77 46 360456 20337 79363549
Dry eye 14.06 13.77 240 360262 36691 79347195
Gingival pain 14.03 13.77 12 360490 8986 79374900
Cell-mediated cytotoxicity 13.90 13.77 6 360496 44 79383842
Blood thyroid stimulating hormone increased 13.89 13.77 14 360488 9694 79374192
Liver abscess 13.87 13.77 5 360497 6049 79377837
Compartment syndrome 13.87 13.77 3 360499 5079 79378807
Pulmonary cavitation 13.86 13.77 26 360476 1630 79382256
Methaemoglobinaemia 13.77 13.77 4 360498 5553 79378333

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AA13 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Selective immunosuppressants
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
MeSH PA D004791 Enzyme Inhibitors
CHEBI has role CHEBI:35442 antiparasitic drugs
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory agent
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:35705 immunosuppressive agents
CHEBI has role CHEBI:37153 protein serine/threonine phosphatase inhibitors
CHEBI has role CHEBI:38637 tyrosine kinase inhibitors
CHEBI has role CHEBI:50266 Prodrugs
CHEBI has role CHEBI:50908 agente hepatotoxico
CHEBI has role CHEBI:68542 DHODH inhibitor
CHEBI has role CHEBI:68543 pyrimidine synthesis inhibitors
FDA EPC N0000175713 Antirheumatic Agent
FDA MoA N0000185501 Dihydroorotate Dehydrogenase Inhibitors
FDA EPC N0000185502 Pyrimidine Synthesis Inhibitor
CHEBI has role CHEBI:49103 drug metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Psoriasis with arthropathy indication 33339001
Rheumatoid arthritis indication 69896004 DOID:7148
Inactive tuberculosis contraindication 11999007
Agranulocytosis contraindication 17182001 DOID:12987
Acute tuberculosis contraindication 25629007
Immunosuppression contraindication 38013005
Hepatic failure contraindication 59927004
Chronic type B viral hepatitis contraindication 61977001
Acute infectious disease contraindication 63171007
Interstitial pneumonia contraindication 64667001
Aspergillosis contraindication 65553006 DOID:13564
Viral hepatitis type B contraindication 66071002 DOID:2043
Kidney disease contraindication 90708001 DOID:557
Pancytopenia contraindication 127034005 DOID:12450
Chronic hepatitis C contraindication 128302006
Liver function tests abnormal contraindication 166603001
Disease of liver contraindication 235856003 DOID:409
Acute hepatitis C contraindication 235866006
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Peripheral nerve disease contraindication 302226006
Neutropenic disorder contraindication 303011007 DOID:1227
Breastfeeding (mother) contraindication 413712001
Pneumocystosis jiroveci pneumonia contraindication 415125002 DOID:11339
Severe Bone Marrow Depression contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.31 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Dihydroorotate dehydrogenase (quinone), mitochondrial Enzyme INHIBITOR IC50 5 CHEMBL CHEMBL
Sodium-dependent noradrenaline transporter Transporter Ki 5.34 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Ki 5.64 DRUG MATRIX
Cytochrome P450 1A2 Enzyme IC50 6.30 DRUG MATRIX
Amine oxidase [flavin-containing] A Enzyme IC50 4.68 DRUG MATRIX
Sodium/nucleoside cotransporter 1 Transporter Ki 5.29 DRUG MATRIX
Dihydroorotate dehydrogenase (quinone), mitochondrial Enzyme IC50 8.05 CHEMBL
Dihydroorotate dehydrogenase (quinone), mitochondrial Enzyme IC50 7.52 CHEMBL

External reference:

IDSource
4021132 VUID
N0000148586 NUI
D00749 KEGG_DRUG
4021132 VANDF
4031717 VANDF
C0063041 UMLSCUI
CHEBI:6402 CHEBI
CHEBI:68540 CHEBI
CHEMBL960 ChEMBL_ID
DB01097 DRUGBANK_ID
D000077339 MESH_DESCRIPTOR_UI
3899 PUBCHEM_CID
6825 IUPHAR_LIGAND_ID
C527525 MESH_SUPPLEMENTAL_RECORD_UI
5079 INN_ID
G162GK9U4W UNII
1310520 RXNORM
11870 MMSL
28846 MMSL
365635 MMSL
63949 MMSL
7491 MMSL
d04349 MMSL
d07905 MMSL
007642 NDDF
014643 NDDF
109143003 SNOMEDCT_US
386981009 SNOMEDCT_US
703785006 SNOMEDCT_US
703786007 SNOMEDCT_US
C1718383 UMLSCUI
DB08880 DRUGBANK_ID
7761 INN_ID
54684141 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Arava HUMAN PRESCRIPTION DRUG LABEL 1 0088-2160 TABLET, FILM COATED 10 mg ORAL NDA 27 sections
Arava HUMAN PRESCRIPTION DRUG LABEL 1 0088-2160 TABLET, FILM COATED 10 mg ORAL NDA 27 sections
Arava HUMAN PRESCRIPTION DRUG LABEL 1 0088-2161 TABLET, FILM COATED 20 mg ORAL NDA 27 sections
Arava HUMAN PRESCRIPTION DRUG LABEL 1 0088-2161 TABLET, FILM COATED 20 mg ORAL NDA 27 sections
Arava HUMAN PRESCRIPTION DRUG LABEL 1 0088-2162 TABLET, FILM COATED 100 mg ORAL NDA 27 sections
Arava HUMAN PRESCRIPTION DRUG LABEL 1 0088-2162 TABLET, FILM COATED 100 mg ORAL NDA 27 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 0955-1735 TABLET, FILM COATED 10 mg ORAL NDA AUTHORIZED GENERIC 27 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 0955-1735 TABLET, FILM COATED 10 mg ORAL NDA AUTHORIZED GENERIC 27 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 0955-1737 TABLET, FILM COATED 20 mg ORAL NDA AUTHORIZED GENERIC 27 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 0955-1737 TABLET, FILM COATED 20 mg ORAL NDA AUTHORIZED GENERIC 27 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 10702-277 TABLET 10 mg ORAL ANDA 18 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 10702-278 TABLET 20 mg Oral ANDA 18 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 23155-043 TABLET 10 mg ORAL ANDA 23 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 23155-043 TABLET 10 mg ORAL ANDA 23 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 23155-044 TABLET 20 mg ORAL ANDA 23 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 23155-044 TABLET 20 mg ORAL ANDA 23 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 35573-447 TABLET, FILM COATED 10 mg ORAL ANDA 27 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 35573-448 TABLET, FILM COATED 20 mg ORAL ANDA 27 sections
LEFLUNOMIDE HUMAN PRESCRIPTION DRUG LABEL 1 42291-420 TABLET 10 mg ORAL ANDA 18 sections
LEFLUNOMIDE HUMAN PRESCRIPTION DRUG LABEL 1 42291-421 TABLET 20 mg ORAL ANDA 18 sections
Leflunomide Human Prescription Drug Label 1 46708-436 TABLET 10 mg ORAL ANDA 26 sections
Leflunomide Human Prescription Drug Label 1 46708-436 TABLET 10 mg ORAL ANDA 26 sections
Leflunomide Human Prescription Drug Label 1 46708-437 TABLET 20 mg ORAL ANDA 26 sections
Leflunomide Human Prescription Drug Label 1 46708-437 TABLET 20 mg ORAL ANDA 26 sections
Leflunomide Human Prescription Drug Label 1 50090-5992 TABLET, FILM COATED 20 mg ORAL ANDA 26 sections
LEFLUNOMIDE HUMAN PRESCRIPTION DRUG LABEL 1 50268-477 TABLET 10 mg ORAL ANDA 18 sections
LEFLUNOMIDE HUMAN PRESCRIPTION DRUG LABEL 1 50268-478 TABLET 20 mg ORAL ANDA 18 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 54868-2319 TABLET, FILM COATED 20 mg ORAL ANDA 26 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 54868-6170 TABLET, FILM COATED 10 mg ORAL ANDA 26 sections
Leflunomide Human Prescription Drug Label 1 59651-348 TABLET, FILM COATED 10 mg ORAL ANDA 26 sections