leflunomide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1552 75706-12-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • leflunomide medac
  • leflunomide
  • arava
  • avara
  • leflunomida
  • leflunomidum
  • lefumide
  • repso
An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
  • Molecular weight: 270.21
  • Formula: C12H9F3N2O2
  • CLOGP: 2.36
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 55.13
  • ALOGS: -3.51
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.02 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.23 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 80 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Sept. 10, 1998 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 8335.01 13.20 11680 381033 370924 55528430
Drug ineffective 6788.83 13.20 17639 375074 901350 54998004
Drug intolerance 4883.97 13.20 7491 385222 257327 55642027
Contraindicated product administered 4035.00 13.20 5689 387024 180597 55718757
Joint swelling 3633.66 13.20 6909 385804 282891 55616463
Treatment failure 2911.75 13.20 4661 388052 165731 55733623
Synovitis 2860.23 13.20 4488 388225 156817 55742537
Arthropathy 2495.07 13.20 4767 387946 195508 55703846
Therapeutic product effect decreased 2356.72 13.20 4230 388483 165222 55734132
Pemphigus 2136.57 13.20 3886 388827 153326 55746028
Systemic lupus erythematosus 1966.46 13.20 4058 388655 176020 55723334
Abdominal discomfort 1912.22 13.20 5222 387491 272052 55627302
Swelling 1833.84 13.20 4694 388019 235077 55664277
Hand deformity 1752.85 13.20 3266 389447 131226 55768128
Glossodynia 1743.65 13.20 3503 389210 148955 55750399
Alopecia 1711.93 13.20 5205 387508 288253 55611101
Pain 1468.53 13.20 8741 383972 654443 55244911
Death 1449.38 13.20 308 392405 341118 55558236
Hepatic enzyme increased 1284.43 13.20 3332 389381 168052 55731302
Arthralgia 1244.65 13.20 6821 385892 494848 55404506
Anti-cyclic citrullinated peptide antibody positive 1150.53 13.20 2286 390427 96314 55803040
Wound 1077.08 13.20 2735 389978 136069 55763285
Hypersensitivity 1014.88 13.20 4001 388712 252407 55646947
Rheumatoid factor positive 1013.18 13.20 1767 390946 67293 55832061
Acute kidney injury 997.03 13.20 229 392484 240534 55658820
Peripheral swelling 984.57 13.20 3731 388982 230995 55668359
Therapeutic product effect incomplete 965.61 13.20 2223 390490 103808 55795546
Hypotension 965.01 13.20 276 392437 250232 55649122
Pericarditis 937.77 13.20 2234 390479 106689 55792665
Musculoskeletal stiffness 929.43 13.20 2791 389922 153216 55746138
Drug hypersensitivity 889.03 13.20 4037 388676 271168 55628186
C-reactive protein abnormal 888.09 13.20 1187 391526 35622 55863732
Rash 852.27 13.20 6115 386598 486932 55412422
Toxicity to various agents 847.27 13.20 257 392456 224307 55675047
Completed suicide 841.73 13.20 19 392694 133814 55765540
Constipation 832.07 13.20 194 392519 201749 55697605
Discomfort 821.54 13.20 2512 390201 139249 55760105
Drug interaction 743.93 13.20 267 392446 209488 55689866
Anaemia 735.55 13.20 481 392232 267030 55632324
Folliculitis 718.49 13.20 1338 391375 53641 55845713
Muscle injury 711.65 13.20 1298 391415 51202 55848152
Infection 709.70 13.20 3021 389692 197185 55702169
Gastrointestinal disorder 686.57 13.20 2033 390680 110669 55788685
Lower respiratory tract infection 657.20 13.20 2026 390687 112768 55786586
Irritable bowel syndrome 654.77 13.20 1464 391249 66994 55832360
Impaired healing 651.07 13.20 1690 391023 85151 55814203
Infusion related reaction 644.38 13.20 3025 389688 205906 55693448
Product use issue 629.10 13.20 2768 389945 183273 55716081
Loss of personal independence in daily activities 627.00 13.20 1600 391113 79769 55819585
Febrile neutropenia 620.70 13.20 27 392686 105518 55793836
Red blood cell sedimentation rate abnormal 617.84 13.20 706 392007 17967 55881387
Psoriatic arthropathy 605.60 13.20 1489 391224 72519 55826835
Helicobacter infection 602.61 13.20 1477 391236 71791 55827563
Dehydration 601.99 13.20 180 392533 158645 55740709
Duodenal ulcer perforation 583.76 13.20 1398 391315 66944 55832410
Ill-defined disorder 575.68 13.20 1393 391320 67150 55832204
Condition aggravated 557.26 13.20 4213 388500 340685 55558669
Seizure 542.03 13.20 107 392606 125012 55774342
Tremor 532.08 13.20 100 392613 120989 55778365
Hyponatraemia 527.63 13.20 51 392662 102088 55797266
Red blood cell sedimentation rate increased 513.45 13.20 919 391794 35704 55863650
Sleep disorder due to general medical condition, insomnia type 503.96 13.20 1004 391709 42334 55857020
Blister 498.40 13.20 1782 390931 107105 55792249
Anxiety 482.72 13.20 384 392329 192788 55706566
Product dose omission issue 482.27 13.20 431 392282 204322 55695032
Maternal exposure during pregnancy 482.26 13.20 2600 390113 186953 55712401
Somnolence 476.35 13.20 274 392439 163139 55736215
Fall 463.95 13.20 1140 391573 356370 55542984
Overdose 463.67 13.20 88 392625 105742 55793612
Dizziness 460.78 13.20 1235 391478 374905 55524449
C-reactive protein increased 446.62 13.20 1385 391328 77299 55822055
Intentional overdose 438.96 13.20 7 392706 68110 55831244
Cardiac arrest 430.62 13.20 49 392664 86265 55813089
Urinary tract infection 413.79 13.20 649 392064 239864 55659490
Bradycardia 407.98 13.20 14 392699 67490 55831864
Disease progression 407.95 13.20 114 392599 105059 55794295
Bone erosion 401.73 13.20 509 392204 14465 55884889
Dyspnoea 399.10 13.20 2463 390250 590114 55309240
Thrombocytopenia 390.45 13.20 233 392480 135991 55763363
Rheumatoid nodule 373.46 13.20 489 392224 14368 55884986
Knee arthroplasty 372.04 13.20 900 391813 43359 55855995
Hypokalaemia 363.23 13.20 104 392609 94333 55805021
Mobility decreased 355.71 13.20 1501 391212 97490 55801864
Neutropenia 354.57 13.20 348 392365 157819 55741535
Electrocardiogram QT prolonged 342.10 13.20 8 392705 54580 55844774
Sepsis 333.15 13.20 291 392422 139549 55759805
Tachycardia 329.75 13.20 163 392550 105713 55793641
Oedema peripheral 313.94 13.20 442 392271 170812 55728542
Abdominal pain 313.31 13.20 854 391859 257951 55641403
Chest discomfort 311.20 13.20 150 392563 98707 55800647
Suicide attempt 309.14 13.20 25 392688 57811 55841543
Hip arthroplasty 304.09 13.20 766 391947 37857 55861497
Stomatitis 302.77 13.20 1651 391062 119159 55780195
Depressed level of consciousness 302.73 13.20 24 392689 56409 55842945
Blood iron abnormal 292.88 13.20 219 392494 3158 55896196
Vision blurred 289.64 13.20 108 392605 82835 55816519
Atrial fibrillation 289.20 13.20 203 392510 108694 55790660
Balance disorder 285.64 13.20 89 392624 76431 55822923
Platelet count decreased 284.25 13.20 197 392516 106186 55793168
Sinusitis 281.18 13.20 2346 390367 195235 55704119
Plasma cell myeloma 280.72 13.20 10 392703 46636 55852718
Hyperkalaemia 277.48 13.20 20 392693 50845 55848509
Muscle spasms 273.84 13.20 333 392380 137038 55762316
Cardio-respiratory arrest 271.95 13.20 33 392680 55288 55844066
Chest pain 271.87 13.20 573 392140 189224 55710130
Respiratory failure 268.97 13.20 165 392548 94897 55804457
Pulmonary embolism 267.34 13.20 213 392500 106911 55792443
Asthenia 264.05 13.20 1363 391350 341610 55557744
Foot deformity 255.63 13.20 534 392179 23291 55876063
Cerebrovascular accident 254.55 13.20 192 392521 99078 55800276
Agitation 248.80 13.20 45 392668 55991 55843363
Hypoglycaemia 247.43 13.20 45 392668 55770 55843584
Cardiac failure congestive 245.76 13.20 154 392559 87566 55811788
Haemoglobin decreased 244.98 13.20 347 392366 133790 55765564
Epistaxis 244.76 13.20 81 392632 66942 55832412
Osteoarthritis 241.39 13.20 1155 391558 79141 55820213
Hallucination 239.92 13.20 30 392683 49119 55850235
Neutrophil count decreased 237.00 13.20 33 392680 49789 55849565
Gastrointestinal haemorrhage 236.36 13.20 117 392596 75834 55823520
Rheumatic fever 235.62 13.20 580 392133 28247 55871107
Inflammation 235.45 13.20 1031 391682 68040 55831314
Osteoporosis 232.94 13.20 846 391867 51206 55848148
Blood cholesterol increased 231.36 13.20 1062 391651 71517 55827837
Asthma 230.46 13.20 268 392445 112502 55786852
Tenosynovitis 230.10 13.20 354 392359 12107 55887247
Cough 229.42 13.20 983 391730 258978 55640376
Blood glucose increased 229.02 13.20 119 392594 75032 55824322
Deformity 228 13.20 318 392395 9937 55889417
Sedation 227.04 13.20 3 392710 34851 55864503
Cognitive disorder 225.76 13.20 36 392677 49097 55850257
Musculoskeletal disorder 225.42 13.20 446 392267 18701 55880653
Swollen joint count increased 225.24 13.20 512 392201 23672 55875682
Syncope 224.51 13.20 254 392459 107945 55791409
Cardiac failure 220.64 13.20 151 392562 81942 55817412
Hypoxia 219.29 13.20 53 392660 53844 55845510
Wrong technique in product usage process 218.27 13.20 67 392646 58101 55841253
Metabolic acidosis 217.55 13.20 17 392696 40437 55858917
Drug tolerance decreased 213.38 13.20 356 392357 13055 55886299
Renal failure 212.74 13.20 275 392438 110225 55789129
COVID-19 211.32 13.20 131 392582 74927 55824427
Myalgia 207.67 13.20 377 392336 131648 55767706
Disability 207.19 13.20 385 392328 15395 55883959
Pancytopenia 207.14 13.20 188 392525 88527 55810827
Arthritis 206.27 13.20 1297 391416 98555 55800799
Lactic acidosis 201.45 13.20 11 392702 35335 55864019
Unresponsive to stimuli 201.33 13.20 4 392709 31721 55867633
Vomiting 199.82 13.20 2370 390343 495858 55403496
Hyperhidrosis 199.45 13.20 217 392496 93871 55805483
Flushing 199.22 13.20 121 392592 69979 55829375
Granuloma skin 197.60 13.20 245 392468 6806 55892548
Joint range of motion decreased 196.44 13.20 500 392213 24865 55874489
Dysphagia 195.72 13.20 170 392543 81777 55817577
Chills 194.79 13.20 258 392455 102346 55797008
Coma 193.14 13.20 87 392626 59568 55839786
Blood parathyroid hormone decreased 191.40 13.20 263 392450 8101 55891253
Decreased appetite 190.91 13.20 833 391880 218398 55680956
Panniculitis 190.79 13.20 286 392427 9556 55889798
Mental status changes 190.27 13.20 20 392693 37481 55861873
Pulmonary oedema 189.94 13.20 60 392653 51083 55848271
Bone pain 189.75 13.20 57 392656 50128 55849226
Nausea 189.62 13.20 3982 388731 760196 55139158
Gastrooesophageal reflux disease 189.00 13.20 181 392532 83076 55816278
White blood cell count decreased 188.28 13.20 371 392342 125619 55773735
Pneumonia aspiration 188.16 13.20 9 392704 32402 55866952
Lethargy 188.12 13.20 62 392651 51379 55847975
Depression 187.98 13.20 636 392077 179481 55719873
International normalised ratio increased 187.84 13.20 39 392674 44002 55855352
Pleural effusion 185.82 13.20 193 392520 85287 55814067
Pulmonary fibrosis 183.95 13.20 540 392173 29218 55870136
Joint stiffness 181.27 13.20 602 392111 34823 55864531
Hyperglycaemia 180.57 13.20 26 392687 38255 55861099
Respiratory arrest 176.20 13.20 9 392704 30616 55868738
Feeling abnormal 176.00 13.20 422 392291 133180 55766174
Deafness transitory 175.28 13.20 129 392584 1813 55897541
Blood pressure decreased 173.36 13.20 98 392615 58952 55840402
Deep vein thrombosis 172.80 13.20 169 392544 76808 55822546
Therapeutic response decreased 172.59 13.20 778 391935 51980 55847374
Finger deformity 170.78 13.20 220 392493 6357 55892997
Neuropathy peripheral 169.79 13.20 285 392428 102608 55796746
Fibromyalgia 169.53 13.20 844 391869 58759 55840595
Rhabdomyolysis 167.34 13.20 39 392674 40619 55858735
Encephalopathy 164.30 13.20 25 392688 35300 55864054
Grip strength decreased 163.58 13.20 355 392358 15901 55883453
Orthostatic hypotension 160.25 13.20 21 392692 33178 55866176
Intentional self-injury 159.20 13.20 3 392710 24989 55874365
Adverse drug reaction 158.27 13.20 883 391830 64249 55835105
Diarrhoea 157.86 13.20 3328 389385 635179 55264175
Fluid retention 156.96 13.20 91 392622 53987 55845367
Disturbance in attention 156.07 13.20 21 392692 32519 55866835
Adverse event 154.57 13.20 780 391933 54596 55844758
Product quality issue 153.37 13.20 20 392693 31716 55867638
Nasopharyngitis 152.68 13.20 2275 390438 218684 55680670
Pneumonia 152.64 13.20 1964 390749 405134 55494220
Liver function test increased 151.05 13.20 486 392227 27647 55871707
Drug withdrawal syndrome 150.68 13.20 7 392706 25850 55873504
Dysarthria 149.38 13.20 45 392668 39505 55859849
Restlessness 149.28 13.20 9 392704 26577 55872777
Ascites 148.71 13.20 39 392674 37505 55861849
Disorientation 145.08 13.20 38 392675 36575 55862779
Urinary retention 142.36 13.20 15 392698 28059 55871295
Premature delivery 141.04 13.20 13 392700 27047 55872307
Hospitalisation 140.90 13.20 190 392523 74810 55824544
Thrombosis 139.82 13.20 125 392588 59302 55840052
Hypervolaemia 139.82 13.20 12 392701 26446 55872908
Skin ulcer 138.99 13.20 586 392127 38022 55861332
Limb deformity 136.89 13.20 152 392561 3743 55895611
Oxygen saturation decreased 136.07 13.20 213 392500 78854 55820500
Intentional product misuse 135.38 13.20 97 392616 51407 55847947
Chronic kidney disease 135.09 13.20 62 392651 41994 55857360
Rectal haemorrhage 134.97 13.20 60 392653 41407 55857947
Full blood count decreased 133.89 13.20 7 392706 23342 55876012
Paraesthesia 132.63 13.20 466 392247 130048 55769306
Chronic obstructive pulmonary disease 132.43 13.20 123 392590 57292 55842062
Pyrexia 132.04 13.20 2091 390622 416682 55482672
Injection site pain 131.58 13.20 400 392313 116718 55782636
Respiratory distress 131.07 13.20 30 392683 31637 55867717
Rheumatoid lung 130.61 13.20 134 392579 3006 55896348
Blood potassium decreased 130.60 13.20 53 392660 38619 55860735
Haemorrhage 129.86 13.20 121 392592 56276 55843078
Cerebral haemorrhage 129.09 13.20 22 392691 28584 55870770
Pulmonary toxicity 129.09 13.20 212 392501 7671 55891683
Skin necrosis 129.04 13.20 274 392439 12087 55887267
Multiple organ dysfunction syndrome 129.02 13.20 107 392606 52663 55846691
Dry skin 128.78 13.20 85 392628 47024 55852330
Altered state of consciousness 128.64 13.20 8 392705 23013 55876341
Hypomagnesaemia 127.79 13.20 13 392700 25002 55874352
Dysgeusia 127.31 13.20 63 392650 40852 55858502
Suicidal ideation 125.90 13.20 130 392583 57612 55841742
Dyskinesia 125.74 13.20 25 392688 29083 55870271
Melaena 124.96 13.20 23 392690 28267 55871087
Generalised tonic-clonic seizure 124.84 13.20 21 392692 27545 55871809
Erythema 124.69 13.20 611 392102 155328 55744026
Urinary incontinence 124.52 13.20 27 392686 29558 55869796
Fatigue 124.10 13.20 6701 386012 781851 55117503
Musculoskeletal deformity 121.40 13.20 94 392619 1432 55897922
Palpitations 121.06 13.20 328 392385 99344 55800010
Lymphocyte count decreased 120.68 13.20 24 392689 27915 55871439
Haematoma 118.11 13.20 38 392675 31981 55867373
Aphasia 117.82 13.20 33 392680 30382 55868972
Cardiac disorder 117.27 13.20 89 392624 45798 55853556
Blood calcium decreased 117.24 13.20 14 392699 23755 55875599
Incorrect dose administered 117.19 13.20 116 392597 52431 55846923
Heart rate increased 116.94 13.20 254 392459 83019 55816335
Abnormal behaviour 116.49 13.20 6 392707 20266 55879088
Dyspnoea exertional 114.91 13.20 127 392586 54562 55844792
Presyncope 114.73 13.20 20 392693 25562 55873792
Type 2 diabetes mellitus 114.28 13.20 636 392077 46226 55853128
Metastases to liver 113.50 13.20 10 392703 21576 55877778
Blood creatinine increased 113.10 13.20 244 392469 79947 55819407
Adverse reaction 112.66 13.20 221 392492 9206 55890148
Muscle spasticity 111.89 13.20 350 392363 19610 55879744
Depressed mood 111.61 13.20 57 392656 36302 55863052
Impaired work ability 110.50 13.20 285 392428 14287 55885067
Epilepsy 110.40 13.20 21 392692 25210 55874144
Liver injury 109.51 13.20 579 392134 41269 55858085
Pulmonary hypertension 109.36 13.20 57 392656 35887 55863467
Aggression 108.45 13.20 13 392700 21993 55877361
Foetal exposure during pregnancy 108.42 13.20 50 392663 33773 55865581
Drug level increased 107.90 13.20 10 392703 20715 55878639
Ear pain 107.43 13.20 464 392249 30426 55868928
Inappropriate schedule of product administration 106.15 13.20 268 392445 83119 55816235
Dysuria 105.59 13.20 41 392672 30688 55868666
Haematochezia 105.21 13.20 90 392623 43628 55855726
Irritability 104.15 13.20 38 392675 29550 55869804
Nodule 103.92 13.20 326 392387 18293 55881061
Flatulence 103.85 13.20 44 392669 31244 55868110
Drug reaction with eosinophilia and systemic symptoms 103.20 13.20 41 392672 30263 55869091
Night sweats 102.95 13.20 563 392150 40650 55858704
Device dislocation 102.87 13.20 17 392696 22589 55876765
Psychotic disorder 102.25 13.20 20 392693 23538 55875816
Colitis 101.94 13.20 85 392628 41726 55857628
Right ventricular failure 100.36 13.20 3 392710 16376 55882978
Memory impairment 99.82 13.20 292 392421 86265 55813089
Ejection fraction decreased 99.58 13.20 11 392702 19830 55879524
Sleep disorder 99.56 13.20 810 391903 66853 55832501
Oropharyngeal pain 98.57 13.20 280 392433 83508 55815846
Full blood count abnormal 98.33 13.20 31 392682 26431 55872923
Foot operation 97.88 13.20 165 392548 6102 55893252
Vertigo 97.76 13.20 143 392570 54429 55844925
Shoulder arthroplasty 97.66 13.20 125 392588 3588 55895766
Metastases to bone 97.45 13.20 11 392702 19497 55879857
Gastrointestinal pain 96.81 13.20 199 392514 8578 55890776
Pulmonary arterial hypertension 96.79 13.20 32 392681 26471 55872883
Intentional product use issue 96.64 13.20 1093 391620 98640 55800714
Body temperature increased 96.01 13.20 483 392230 33759 55865595
Sleep apnoea syndrome 96.00 13.20 31 392682 26030 55873324
Withdrawal syndrome 95.87 13.20 9 392704 18453 55880901
Vaginal haemorrhage 95.53 13.20 30 392683 25643 55873711
Abdominal distension 95.35 13.20 254 392459 77372 55821982
Septic shock 95.34 13.20 174 392539 60661 55838693
Joint destruction 95.29 13.20 145 392568 4910 55894444
Oral mucosal exfoliation 95.19 13.20 83 392630 1506 55897848
Hallucination, visual 94.88 13.20 7 392706 17461 55881893
Sciatica 94.56 13.20 396 392317 25614 55873740
Acute respiratory failure 94.52 13.20 49 392664 30945 55868409
Pancreatitis acute 92.35 13.20 30 392683 25094 55874260
Neutropenic sepsis 92.26 13.20 3 392710 15182 55884172
Accidental overdose 91.75 13.20 16 392697 20445 55878909
Circulatory collapse 91.70 13.20 17 392696 20786 55878568
Blood creatine phosphokinase increased 91.67 13.20 40 392673 27912 55871442
Mucosal inflammation 91.50 13.20 98 392615 42712 55856642
Arrhythmia 90.99 13.20 67 392646 35016 55864338
Blood urea increased 90.35 13.20 29 392684 24444 55874910
Hypocalcaemia 89.91 13.20 44 392669 28716 55870638
Neurotoxicity 89.74 13.20 5 392708 15790 55883564
Hemiparesis 89.66 13.20 20 392693 21470 55877884
Abdominal pain lower 89.54 13.20 25 392688 23067 55876287
Enthesopathy 89.15 13.20 183 392530 7880 55891474
Bone marrow failure 88.85 13.20 43 392670 28243 55871111
Transient ischaemic attack 88.55 13.20 63 392650 33514 55865840
Ventricular tachycardia 88.40 13.20 8 392705 16893 55882461
Clostridium difficile colitis 87.74 13.20 13 392700 18725 55880629
Sinus tachycardia 87.59 13.20 24 392689 22420 55876934
Red blood cell sedimentation rate 87.54 13.20 128 392585 4180 55895174
Dementia 87.43 13.20 9 392704 17149 55882205
Retinal toxicity 87.24 13.20 70 392643 1126 55898228
Tuberculin test positive 86.97 13.20 112 392601 3235 55896119
Myocardial infarction 86.23 13.20 344 392369 92526 55806828
Physical disability 86 13.20 94 392619 2273 55897081
Pericardial effusion 85.83 13.20 41 392672 27134 55872220
Panic attack 85.36 13.20 19 392694 20428 55878926
X-ray abnormal 85.36 13.20 127 392586 4214 55895140
Weight decreased 84.31 13.20 1177 391536 239537 55659817
Product administration error 84.31 13.20 21 392692 20908 55878446
Joint effusion 84.21 13.20 262 392451 14636 55884718
Acute myocardial infarction 84.21 13.20 54 392659 30339 55869015
Joint laxity 83.69 13.20 94 392619 2345 55897009
Therapy interrupted 83.51 13.20 37 392676 25588 55873766
Therapy cessation 83.29 13.20 43 392670 27221 55872133
Rash erythematous 83.19 13.20 82 392631 37139 55862215
Hepatotoxicity 82.86 13.20 433 392280 30720 55868634
Inappropriate antidiuretic hormone secretion 82.58 13.20 3 392710 13753 55885601
Abortion spontaneous 82.00 13.20 111 392602 43642 55855712
Upper gastrointestinal haemorrhage 81.80 13.20 11 392702 17043 55882311
Toxic epidermal necrolysis 81.58 13.20 26 392687 22016 55877338
Blood sodium decreased 81.51 13.20 27 392686 22307 55877047
Face oedema 81.50 13.20 15 392698 18437 55880917
Acute myeloid leukaemia 81.28 13.20 11 392702 16961 55882393
Pollakiuria 81.18 13.20 37 392676 25165 55874189
Burning sensation 81.12 13.20 134 392579 48562 55850792
Haemoptysis 80.98 13.20 42 392671 26518 55872836
Angioedema 80.94 13.20 102 392611 41351 55858003
Musculoskeletal pain 80.71 13.20 894 391819 80258 55819096
Rheumatoid factor negative 80.70 13.20 51 392662 549 55898805
Drug eruption 80.58 13.20 375 392338 25388 55873966
Arthrodesis 80.17 13.20 96 392617 2570 55896784
Renal impairment 80.09 13.20 291 392422 80422 55818932
Myoclonus 80.05 13.20 7 392706 15196 55884158
Eye pain 79.88 13.20 59 392654 30788 55868566
Diabetic ketoacidosis 79.87 13.20 17 392696 18854 55880500
Accidental exposure to product 79.68 13.20 36 392677 24611 55874743
Status epilepticus 79.64 13.20 7 392706 15134 55884220
Emotional distress 79.60 13.20 55 392658 29708 55869646
Product prescribing error 79.56 13.20 31 392682 23155 55876199
Cerebral infarction 79.04 13.20 29 392684 22476 55876878
Haematuria 78.89 13.20 45 392668 26942 55872412
Product use in unapproved indication 78.59 13.20 617 392096 140205 55759149
Hepatic function abnormal 78.55 13.20 75 392638 34483 55864871
Spinal column injury 78.52 13.20 81 392632 1829 55897525
Cholestasis 78.50 13.20 45 392668 26868 55872486
Skin exfoliation 78.28 13.20 85 392628 36815 55862539
Cholelithiasis 78.21 13.20 96 392617 39368 55859986
Sinus bradycardia 78.13 13.20 4 392709 13582 55885772
Drug ineffective for unapproved indication 77.79 13.20 41 392672 25652 55873702
Multiple sclerosis 77.57 13.20 49 392664 27753 55871601
Blood bilirubin increased 77.44 13.20 71 392642 33283 55866071
Head injury 75.89 13.20 40 392673 25026 55874328
Electrolyte imbalance 74.79 13.20 17 392696 18016 55881338
Ulcer 74.58 13.20 333 392380 22152 55877202
Tinnitus 74.57 13.20 60 392653 29982 55869372
Cellulitis 74.51 13.20 270 392443 74679 55824675
Device issue 74.46 13.20 27 392686 21079 55878275
Ankylosing spondylitis 74.04 13.20 193 392520 9737 55889617
Pain in jaw 73.59 13.20 103 392610 39933 55859421
Product substitution issue 73.51 13.20 8 392705 14591 55884763
Leukocytosis 73.46 13.20 37 392676 23754 55875600
Agranulocytosis 73.40 13.20 33 392680 22626 55876728
Blood pressure increased 73.37 13.20 653 392060 144523 55754831
Creatinine renal clearance decreased 73.25 13.20 8 392705 14551 55884803
Surgical failure 73.14 13.20 57 392656 877 55898477
Loss of consciousness 72.33 13.20 456 392257 108893 55790461
Muscle twitching 72.18 13.20 13 392700 16229 55883125
Disseminated intravascular coagulation 71.94 13.20 18 392695 17867 55881487
Swelling face 71.51 13.20 180 392533 55889 55843465
Respiratory disorder 70.62 13.20 442 392271 33515 55865839
Intestinal obstruction 70.51 13.20 55 392658 27916 55871438
Pruritus allergic 70.38 13.20 64 392649 1230 55898124
Speech disorder 70.38 13.20 95 392618 37398 55861956
Poisoning 69.98 13.20 5 392708 12808 55886546
Joint injury 69.91 13.20 359 392354 25295 55874059
Lip swelling 69.66 13.20 49 392664 26223 55873131
Small intestinal obstruction 69.51 13.20 16 392697 16809 55882545
Lacrimation increased 69.06 13.20 21 392692 18327 55881027
Coordination abnormal 68.72 13.20 5 392708 12616 55886738
Mental disorder 68.09 13.20 40 392673 23564 55875790
Muscular weakness 67.84 13.20 438 392275 104014 55795340
Renal disorder 67.58 13.20 64 392649 29541 55869813
Seronegative arthritis 67.12 13.20 89 392624 2647 55896707
Pallor 66.77 13.20 43 392670 24106 55875248
Transfusion 66.59 13.20 8 392705 13512 55885842
Stevens-Johnson syndrome 65.95 13.20 38 392675 22625 55876729
Loose body in joint 65.76 13.20 61 392652 1204 55898150
Infusion site pain 65.71 13.20 9 392704 13753 55885601
Bone swelling 65.47 13.20 66 392647 1449 55897905
Breast cancer metastatic 65.34 13.20 14 392699 15455 55883899
Dysphonia 64.81 13.20 121 392592 41826 55857528
Red cell distribution width decreased 64.68 13.20 68 392645 1571 55897783
Dystonia 64.64 13.20 6 392707 12415 55886939
Mania 64.37 13.20 4 392709 11516 55887838
Bacteraemia 64.30 13.20 15 392698 15616 55883738
Haemorrhage intracranial 64.19 13.20 7 392706 12748 55886606
Diplopia 63.92 13.20 31 392682 20338 55879016
Dislocation of vertebra 63.56 13.20 126 392587 5289 55894065
Feeling hot 62.42 13.20 123 392590 41664 55857690
Vascular access complication 62.39 13.20 68 392645 1639 55897715
Hypothermia 62.36 13.20 7 392706 12463 55886891
Paranoia 62.31 13.20 3 392710 10741 55888613
Incontinence 62.25 13.20 3 392710 10732 55888622
Labelled drug-drug interaction medication error 61.92 13.20 5 392708 11581 55887773
Skin discolouration 61.55 13.20 90 392623 34266 55865088
Pancreatitis 61.23 13.20 140 392573 44940 55854414
Hot flush 61.15 13.20 148 392565 46578 55852776
Premature labour 61.15 13.20 6 392707 11876 55887478
Eosinophilia 60.84 13.20 32 392681 20045 55879309
Complication associated with device 60.68 13.20 16 392697 15334 55884020
Anuria 60.36 13.20 6 392707 11754 55887600
Metastases to central nervous system 60.22 13.20 7 392706 12129 55887225
Basal cell carcinoma 59.96 13.20 340 392373 24881 55874473
Visual acuity reduced 59.96 13.20 35 392678 20691 55878663
Tuberculosis 59.62 13.20 191 392522 10838 55888516
Subdural haematoma 59.56 13.20 11 392702 13488 55885866
Caesarean section 59.52 13.20 19 392694 16072 55883282
Incorrect product administration duration 59.51 13.20 3 392710 10323 55889031
Mitral valve incompetence 59.49 13.20 26 392687 18127 55881227
Cardiogenic shock 59.11 13.20 20 392693 16305 55883049
Viral infection 58.90 13.20 82 392631 31864 55867490
Ischaemic stroke 58.65 13.20 22 392691 16820 55882534
Malnutrition 58.51 13.20 13 392700 13995 55885359
Blood glucose decreased 58.46 13.20 30 392683 19057 55880297
Diabetes mellitus inadequate control 58.34 13.20 13 392700 13967 55885387
Fear 58.06 13.20 16 392697 14892 55884462
Obstructive airways disorder 57.84 13.20 24 392689 17258 55882096
Metastases to lung 57.55 13.20 7 392706 11711 55887643
Tachypnoea 57.46 13.20 18 392695 15412 55883942
Respiratory depression 57.37 13.20 9 392704 12426 55886928
Paraesthesia oral 57.23 13.20 15 392698 14434 55884920
Nervousness 57.06 13.20 71 392642 28944 55870410
Haematemesis 56.94 13.20 70 392643 28688 55870666
Peritonitis 56.70 13.20 21 392692 16181 55883173
Device difficult to use 56.53 13.20 5 392708 10756 55888598
Therapeutic response unexpected 56.51 13.20 24 392689 17020 55882334
Systemic lupus erythematosus rash 56.48 13.20 69 392644 1887 55897467
Mean platelet volume decreased 56.35 13.20 73 392640 2121 55897233
Left ventricular dysfunction 56.25 13.20 6 392707 11117 55888237
Delirium 56.17 13.20 134 392579 42383 55856971
Brain oedema 56.07 13.20 12 392701 13259 55886095
Mydriasis 55.91 13.20 6 392707 11065 55888289
Hepatic failure 55.90 13.20 92 392621 33394 55865960
Cholecystitis chronic 55.65 13.20 3 392710 9745 55889609
Exostosis 55.48 13.20 229 392484 14714 55884640
International normalised ratio fluctuation 55.37 13.20 76 392637 2338 55897016
Joint dislocation 54.89 13.20 237 392476 15536 55883818
Ankle arthroplasty 54.83 13.20 59 392654 1401 55897953
Extrapyramidal disorder 54.67 13.20 10 392703 12346 55887008
Cyanosis 54.48 13.20 21 392692 15789 55883565
Emotional disorder 54.29 13.20 10 392703 12285 55887069
Breast cancer stage III 54.21 13.20 140 392573 7023 55892331
Wrist deformity 54.05 13.20 66 392647 1804 55897550
Ileus 53.88 13.20 15 392698 13867 55885487
Blood magnesium decreased 53.87 13.20 9 392704 11865 55887489
Gastritis 53.70 13.20 100 392613 34602 55864752
Muscle rigidity 53.34 13.20 6 392707 10665 55888689
Ataxia 53.28 13.20 17 392696 14386 55884968
Macular degeneration 53.20 13.20 33 392680 18875 55880479
Adjustment disorder with depressed mood 53.13 13.20 113 392600 4990 55894364
Malaise 53.05 13.20 2064 390649 365796 55533558
Clostridium difficile infection 53.02 13.20 67 392646 27131 55872223
Productive cough 53.00 13.20 207 392506 56025 55843329
Eye swelling 52.67 13.20 43 392670 21333 55878021
Hypersomnia 52.62 13.20 24 392689 16317 55883037
Premature baby 52.01 13.20 35 392678 19170 55880184
Shock 51.95 13.20 45 392668 21683 55877671
Renal tubular necrosis 51.90 13.20 7 392706 10821 55888533
Mean cell volume decreased 51.13 13.20 89 392624 3379 55895975
Swollen tongue 50.92 13.20 83 392630 30241 55869113
Back injury 50.89 13.20 147 392566 7879 55891475
Nightmare 50.72 13.20 27 392686 16799 55882555
Haemorrhoids 50.59 13.20 40 392673 20166 55879188
Product label confusion 50.54 13.20 48 392665 977 55898377
Throat tightness 50.49 13.20 49 392664 22358 55876996
Retinitis 50.44 13.20 99 392614 4125 55895229
Myopathy 50.37 13.20 5 392708 9807 55889547
Device related infection 50.29 13.20 47 392666 21833 55877521
Coronary artery disease 50.13 13.20 86 392627 30710 55868644
Demyelination 50.11 13.20 125 392588 6137 55893217
Multiple fractures 50.02 13.20 138 392575 7203 55892151
Investigation abnormal 49.96 13.20 61 392652 1667 55897687
General physical health deterioration 49.71 13.20 1545 391168 168465 55730889
Ocular hyperaemia 49.60 13.20 48 392665 21931 55877423
Sensitivity to weather change 49.34 13.20 129 392584 6520 55892834
Cystitis 49.17 13.20 176 392537 48862 55850492
Aspiration 49.14 13.20 5 392708 9616 55889738
Underdose 48.99 13.20 56 392657 23701 55875653
Infusion site reaction 48.89 13.20 79 392634 2819 55896535
Supraventricular tachycardia 48.62 13.20 16 392697 13275 55886079
Tricuspid valve incompetence 48.40 13.20 16 392697 13237 55886117
Influenza 48.32 13.20 428 392285 94833 55804521
Hyperbilirubinaemia 48.15 13.20 7 392706 10228 55889126
Wheezing 48.00 13.20 316 392397 74710 55824644
Acidosis 47.55 13.20 8 392705 10493 55888861
Hypophosphataemia 47.15 13.20 6 392707 9696 55889658
No adverse event 46.98 13.20 116 392597 36258 55863096
Colitis ischaemic 46.80 13.20 7 392706 10013 55889341
Retching 46.57 13.20 18 392695 13512 55885842
Infusion site erythema 46.54 13.20 6 392707 9600 55889754
Pharyngitis 46.12 13.20 253 392460 18285 55881069
Bloody discharge 46.11 13.20 54 392659 1411 55897943
Ventricular fibrillation 46.08 13.20 10 392703 10942 55888412
Cardiomegaly 45.97 13.20 29 392684 16438 55882916
Jaundice 45.55 13.20 75 392638 27219 55872135
Blindness 45.45 13.20 37 392676 18384 55880970
Pneumonia viral 45.29 13.20 131 392582 7027 55892327
Wrist surgery 45.22 13.20 41 392672 785 55898569
Hepatic encephalopathy 45.12 13.20 8 392705 10102 55889252
Blood calcium increased 45.06 13.20 3 392710 8151 55891203
Urine output decreased 45.02 13.20 10 392703 10767 55888587
Synovial cyst 44.84 13.20 154 392559 9060 55890294
Aplastic anaemia 44.68 13.20 5 392708 8923 55890431
Bone density abnormal 44.65 13.20 81 392632 3178 55896176
Anal incontinence 44.64 13.20 15 392698 12283 55887071
Nasal congestion 44.36 13.20 222 392491 56148 55843206
Fine motor skill dysfunction 44.34 13.20 97 392616 4368 55894986
Gastric disorder 44.30 13.20 389 392324 32821 55866533
Transaminases abnormal 43.88 13.20 35 392678 558 55898796
Delusion 43.75 13.20 12 392701 11203 55888151
Dactylitis 43.73 13.20 63 392650 2029 55897325
Tumour lysis syndrome 43.54 13.20 3 392710 7920 55891434
Infusion site swelling 43.52 13.20 3 392710 7918 55891436
Stress cardiomyopathy 43.45 13.20 4 392709 8332 55891022
Bronchitis 43.34 13.20 538 392175 111773 55787581
Dermatitis atopic 43.21 13.20 4 392709 8295 55891059
Toxic skin eruption 43.17 13.20 14 392699 11725 55887629
Ear infection 43.01 13.20 369 392344 30926 55868428
Myelodysplastic syndrome 42.97 13.20 31 392682 16375 55882979
Acute respiratory distress syndrome 42.75 13.20 54 392659 21872 55877482
Hip fracture 42.39 13.20 77 392636 26896 55872458
Bronchitis chronic 42.32 13.20 89 392624 3899 55895455
Abnormal dreams 42.28 13.20 8 392705 9641 55889713
Migraine 42.26 13.20 394 392319 86403 55812951
Lymphopenia 42.26 13.20 33 392680 16741 55882613
Electrocardiogram abnormal 42.21 13.20 4 392709 8140 55891214
Mental impairment 42.04 13.20 18 392695 12704 55886650
Central nervous system lesion 41.96 13.20 9 392704 9929 55889425
Myelosuppression 41.91 13.20 36 392677 17419 55881935
Anti-cyclic citrullinated peptide antibody 41.75 13.20 85 392628 3638 55895716
Ventricular extrasystoles 41.72 13.20 12 392701 10858 55888496
Tardive dyskinesia 41.47 13.20 4 392709 8027 55891327
Hepatocellular injury 41.39 13.20 76 392637 26438 55872916
Mycotic allergy 41.34 13.20 39 392674 787 55898567
Fear of injection 40.99 13.20 119 392594 6396 55892958
Rash macular 40.95 13.20 50 392663 20554 55878800
Colitis ulcerative 40.73 13.20 67 392646 24324 55875030
Taste disorder 40.61 13.20 9 392704 9706 55889648
Normal newborn 40.55 13.20 3 392710 7467 55891887
Atelectasis 40.37 13.20 45 392668 19263 55880091
Angina pectoris 40.37 13.20 84 392629 27892 55871462
Cytomegalovirus infection 40.32 13.20 45 392668 19251 55880103
Headache 40.23 13.20 3356 389357 555688 55343666
Injection site mass 39.88 13.20 35 392678 16758 55882596
Cutaneous vasculitis 39.87 13.20 97 392616 4687 55894667
Renal injury 39.73 13.20 7 392706 8880 55890474
Muscle tightness 39.72 13.20 13 392700 10823 55888531
Urticarial vasculitis 39.65 13.20 35 392678 646 55898708
Gait disturbance 39.55 13.20 1452 391261 161869 55737485
Pre-eclampsia 39.47 13.20 6 392707 8480 55890874
Joint arthroplasty 39.47 13.20 68 392645 2560 55896794
Restless legs syndrome 39.43 13.20 36 392677 16911 55882443
Throat irritation 39.32 13.20 108 392605 32575 55866779
Frequent bowel movements 39.28 13.20 34 392679 16390 55882964
Gestational diabetes 39.16 13.20 5 392708 8059 55891295
Haemodynamic instability 38.49 13.20 6 392707 8323 55891031
Apathy 38.46 13.20 5 392708 7949 55891405
Hypotonia 38.44 13.20 7 392706 8670 55890684
Interstitial lung disease 38.32 13.20 585 392128 56478 55842876
Amenorrhoea 38.22 13.20 8 392705 8978 55890376
Head discomfort 38.13 13.20 18 392695 11996 55887358
Hyperlipidaemia 38.09 13.20 42 392671 18067 55881287
Sensory loss 37.91 13.20 8 392705 8927 55890427
Neck deformity 37.83 13.20 58 392655 1977 55897377
Therapy non-responder 37.80 13.20 620 392093 60735 55838619
Ovarian cyst 37.76 13.20 29 392684 14837 55884517
White blood cell count increased 37.71 13.20 172 392541 44587 55854767
Acute generalised exanthematous pustulosis 37.68 13.20 11 392702 9858 55889496
Oesophagitis 37.56 13.20 26 392687 14031 55885323
Onychomycosis 37.53 13.20 116 392597 6456 55892898
Osteonecrosis of jaw 37.38 13.20 114 392599 33244 55866110
Faeces discoloured 37.34 13.20 38 392675 16958 55882396
Oliguria 36.98 13.20 7 392706 8433 55890921
Tubulointerstitial nephritis 36.91 13.20 37 392676 16628 55882726
Extremity contracture 36.74 13.20 45 392668 1234 55898120
Bedridden 36.59 13.20 156 392557 10169 55889185
Shock haemorrhagic 36.51 13.20 9 392704 9024 55890330
Feeling cold 36.51 13.20 57 392656 21130 55878224
Hypothyroidism 36.38 13.20 140 392573 38056 55861298
Eosinophil count increased 36.32 13.20 11 392702 9626 55889728
Chromaturia 36.32 13.20 32 392681 15293 55884061
Pulmonary mass 36.25 13.20 256 392457 20214 55879140
Troponin increased 36.09 13.20 8 392705 8627 55890727
Lower gastrointestinal haemorrhage 36.03 13.20 4 392709 7183 55892171
Atrioventricular block first degree 35.93 13.20 3 392710 6762 55892592
Soft tissue disorder 35.88 13.20 87 392626 4195 55895159
Haemodialysis 35.83 13.20 8 392705 8583 55890771
Ovarian neoplasm 35.60 13.20 37 392676 843 55898511
Hair follicle tumour benign 35.59 13.20 26 392687 361 55898993
Influenza like illness 35.51 13.20 264 392449 60724 55838630
Eyelid oedema 35.31 13.20 12 392701 9756 55889598
Allergic oedema 35.29 13.20 35 392678 753 55898601
Thyroid neoplasm 34.97 13.20 80 392633 3713 55895641
Unevaluable event 34.62 13.20 193 392520 47494 55851860
Coagulopathy 34.54 13.20 48 392665 18668 55880686
Respiratory tract infection 34.49 13.20 132 392581 35939 55863415
Pustular psoriasis 34.38 13.20 88 392625 4390 55894964
Cholecystitis 34.38 13.20 30 392683 14405 55884949
Back pain 34.29 13.20 1330 391383 235840 55663514
Skin papilloma 34.24 13.20 88 392625 4401 55894953
Atrioventricular block 34.11 13.20 4 392709 6883 55892471
Device breakage 34.10 13.20 14 392699 10133 55889221
Upper respiratory tract infection 34.10 13.20 325 392388 70963 55828391
Blood loss anaemia 34.05 13.20 8 392705 8289 55891065
Glomerular filtration rate decreased 34.02 13.20 22 392691 12307 55887047
Apnoea 33.96 13.20 5 392708 7237 55892117
Lupus-like syndrome 33.92 13.20 174 392539 12253 55887101
Eructation 33.88 13.20 6 392707 7582 55891772
Hereditary angioedema 33.77 13.20 4 392709 6831 55892523
Rib fracture 33.71 13.20 56 392657 20253 55879101
Sinus disorder 33.65 13.20 58 392655 20676 55878678
Posterior reversible encephalopathy syndrome 33.59 13.20 37 392676 15923 55883431
Device malfunction 33.31 13.20 38 392675 16098 55883256
Hypermobility syndrome 33.27 13.20 34 392679 759 55898595
Rhinitis allergic 33.18 13.20 9 392704 8465 55890889
Epstein-Barr virus infection 33.10 13.20 6 392707 7457 55891897
Skin laceration 33.07 13.20 56 392657 20100 55879254
Mouth ulceration 32.95 13.20 334 392379 29306 55870048
Pemphigoid 32.90 13.20 3 392710 6297 55893057
Hemiplegia 32.77 13.20 9 392704 8395 55890959
Infiltration anaesthesia 32.73 13.20 19 392694 173 55899181
Hyperthyroidism 32.72 13.20 27 392686 13325 55886029
Peripheral coldness 32.70 13.20 18 392695 10993 55888361
Neuralgia 32.65 13.20 73 392640 23622 55875732
Mean cell haemoglobin decreased 32.62 13.20 85 392628 4287 55895067
Femur fracture 32.50 13.20 418 392295 38877 55860477
Dermatitis contact 32.26 13.20 13 392700 9514 55889840
Mycobacterium tuberculosis complex test positive 32.24 13.20 53 392660 1919 55897435
Anticipatory anxiety 32.12 13.20 38 392675 1004 55898350
Acute coronary syndrome 31.99 13.20 14 392699 9754 55889600
Vasculitic rash 31.96 13.20 42 392671 1238 55898116
Musculoskeletal chest pain 31.83 13.20 55 392658 19586 55879768
Polyarthritis 31.81 13.20 133 392580 8595 55890759
Atrial septal defect 31.67 13.20 4 392709 6502 55892852
End stage renal disease 31.67 13.20 3 392710 6108 55893246
Haemolytic anaemia 31.53 13.20 14 392699 9671 55889683
Mood altered 31.51 13.20 28 392685 13327 55886027
Polyomavirus-associated nephropathy 31.46 13.20 48 392665 1629 55897725
Injection site erythema 31.40 13.20 367 392346 77081 55822273
Alanine aminotransferase abnormal 31.29 13.20 83 392630 4232 55895122
Menstruation irregular 30.98 13.20 4 392709 6392 55892962
Blood triglycerides increased 30.67 13.20 22 392691 11655 55887699
Pre-existing condition improved 30.63 13.20 7 392706 7391 55891963
Toxic encephalopathy 30.55 13.20 3 392710 5935 55893419
Heavy menstrual bleeding 30.49 13.20 41 392672 16168 55883186
Seasonal allergy 30.47 13.20 45 392668 17063 55882291
Lymphadenopathy 30.44 13.20 134 392579 35074 55864280
Flank pain 30.38 13.20 33 392680 14292 55885062
Thirst 30.32 13.20 20 392693 11070 55888284
Motor dysfunction 30.28 13.20 14 392699 9443 55889911
Atrial flutter 30.26 13.20 13 392700 9156 55890198
Drug resistance 30.22 13.20 61 392652 20481 55878873
Bradyphrenia 30.07 13.20 5 392708 6615 55892739
Hypoacusis 30.05 13.20 67 392646 21701 55877653
Sensory disturbance 29.96 13.20 26 392687 12517 55886837
Food allergy 29.94 13.20 12 392701 8812 55890542
Contusion 29.92 13.20 1137 391576 127293 55772061
Thinking abnormal 29.89 13.20 16 392697 9925 55889429
Acute pulmonary oedema 29.88 13.20 8 392705 7589 55891765
Nystagmus 29.82 13.20 3 392710 5822 55893532
Procedural pain 29.76 13.20 42 392671 16229 55883125
Failure to thrive 29.76 13.20 5 392708 6565 55892789
Gastroenteritis viral 29.74 13.20 61 392652 20363 55878991
Labile blood pressure 29.73 13.20 47 392666 1646 55897708
Immune thrombocytopenia 29.67 13.20 15 392698 9610 55889744
Sudden death 29.67 13.20 15 392698 9610 55889744
Walking aid user 29.48 13.20 127 392586 8316 55891038
Immobile 29.48 13.20 95 392618 5407 55893947
Increased appetite 29.44 13.20 12 392701 8723 55890631
Injection site haemorrhage 29.30 13.20 70 392643 22131 55877223
Hypercholesterolaemia 29.23 13.20 187 392526 14286 55885068
Angina unstable 29.16 13.20 6 392707 6815 55892539
Neutrophil count increased 29.03 13.20 37 392676 14928 55884426
Generalised oedema 29.02 13.20 35 392678 14466 55884888
Disease susceptibility 29.02 13.20 18 392695 187 55899167
Pulmonary haemorrhage 28.93 13.20 6 392707 6777 55892577
Spinal stenosis 28.88 13.20 182 392531 13832 55885522
Nocturia 28.87 13.20 7 392706 7099 55892255
Blood lactic acid increased 28.87 13.20 4 392709 6060 55893294
Foetal growth restriction 28.83 13.20 7 392706 7092 55892262
Lymphoedema 28.77 13.20 19 392694 10511 55888843
Cardiomyopathy 28.72 13.20 43 392670 16215 55883139
Drug level decreased 28.62 13.20 7 392706 7057 55892297
Dialysis 28.61 13.20 16 392697 9686 55889668
Progressive multifocal leukoencephalopathy 28.57 13.20 25 392688 11988 55887366
Staphylococcal infection 28.55 13.20 150 392563 37468 55861886
Fistula 28.52 13.20 13 392700 8842 55890512
Hepatitis 28.47 13.20 375 392338 35066 55864288
Oedema 28.46 13.20 401 392312 81519 55817835
Haematocrit decreased 28.43 13.20 146 392567 36683 55862671
Osteoporotic fracture 28.39 13.20 68 392645 3253 55896101
Impaired gastric emptying 28.35 13.20 134 392579 9129 55890225
Heart rate irregular 28.26 13.20 64 392649 20615 55878739
Escherichia infection 28.25 13.20 24 392689 11675 55887679
Spinal compression fracture 28.14 13.20 30 392683 13104 55886250
Prothrombin time prolonged 28.11 13.20 14 392699 9046 55890308
Major depression 27.97 13.20 9 392704 7575 55891779
Bipolar disorder 27.95 13.20 9 392704 7571 55891783
Purpura 27.90 13.20 19 392694 10343 55889011
Hypoalbuminaemia 27.80 13.20 20 392693 10579 55888775
Subarachnoid haemorrhage 27.74 13.20 23 392690 11324 55888030
Suspected suicide 27.51 13.20 3 392710 5463 55893891
Product storage error 27.40 13.20 31 392682 13182 55886172
Functional gastrointestinal disorder 27.37 13.20 73 392640 3734 55895620
Blood albumin decreased 27.16 13.20 33 392680 13595 55885759
Cerebral ischaemia 27.16 13.20 5 392708 6145 55893209
Injection site swelling 27.14 13.20 185 392528 43393 55855961
Lung neoplasm malignant 27.03 13.20 50 392663 17346 55882008
Myocarditis 27.01 13.20 14 392699 8844 55890510
Cold sweat 26.97 13.20 22 392691 10921 55888433
Granulocytopenia 26.72 13.20 3 392710 5341 55894013
Nephropathy toxic 26.72 13.20 13 392700 8514 55890840
Hiatus hernia 26.71 13.20 61 392652 19591 55879763
Hepatitis cholestatic 26.69 13.20 6 392707 6408 55892946
Hypercalcaemia 26.66 13.20 283 392430 25128 55874226
Petechiae 26.60 13.20 31 392682 13008 55886346
Infusion site extravasation 26.52 13.20 12 392701 8198 55891156
Skin reaction 26.51 13.20 169 392544 12894 55886460
Mass excision 26.48 13.20 20 392693 293 55899061
Rhinorrhoea 26.45 13.20 262 392451 56775 55842579
Brain injury 26.34 13.20 6 392707 6349 55893005
Ankle deformity 26.21 13.20 23 392690 421 55898933
Ageusia 26.05 13.20 29 392684 12422 55886932
White blood cell count abnormal 25.93 13.20 95 392618 5772 55893582
Vascular device infection 25.89 13.20 4 392709 5586 55893768
Poor quality sleep 25.88 13.20 53 392660 17702 55881652
Arteriosclerosis coronary artery 25.86 13.20 11 392702 7794 55891560
Hypoaesthesia oral 25.75 13.20 25 392688 11406 55887948
Unintended pregnancy 25.74 13.20 3 392710 5188 55894166
Injection site reaction 25.74 13.20 518 392195 52729 55846625
Myocardial ischaemia 25.59 13.20 28 392685 12088 55887266
Pelvic pain 25.54 13.20 27 392686 11840 55887514
Hyperthermia 25.41 13.20 13 392700 8272 55891082
Exercise tolerance decreased 25.40 13.20 3 392710 5135 55894219
Enterocolitis 25.21 13.20 9 392704 7095 55892259
Extra dose administered 25.16 13.20 4 392709 5469 55893885
Psychomotor hyperactivity 25.14 13.20 19 392694 9801 55889553
Personality change 25.11 13.20 5 392708 5812 55893542
Erythema multiforme 25.09 13.20 18 392695 9536 55889818
Heart rate decreased 24.99 13.20 172 392541 40255 55859099
Secretion discharge 24.95 13.20 142 392571 10404 55888950
Joint space narrowing 24.92 13.20 21 392692 363 55898991
Salivary hypersecretion 24.90 13.20 9 392704 7041 55892313
Localised oedema 24.58 13.20 3 392710 5006 55894348
Scleroderma 24.53 13.20 3 392710 4998 55894356
Upper-airway cough syndrome 24.50 13.20 18 392695 9420 55889934
Glycosylated haemoglobin increased 24.48 13.20 25 392688 11140 55888214
Bundle branch block left 24.46 13.20 7 392706 6355 55892999
Hepatic cytolysis 24.40 13.20 24 392689 10882 55888472
Allergy to chemicals 24.32 13.20 53 392660 2380 55896974
Oral discomfort 24.23 13.20 119 392594 8236 55891118
Hypoaesthesia 24.19 13.20 777 391936 140714 55758640
Photophobia 24.18 13.20 47 392666 16003 55883351
Oligohydramnios 24.17 13.20 6 392707 5988 55893366
Colitis microscopic 24.16 13.20 114 392599 7761 55891593
Hyperventilation 24.08 13.20 5 392708 5643 55893711
Klebsiella infection 24.04 13.20 12 392701 7744 55891610
Polyp 23.86 13.20 6 392707 5936 55893418
Concussion 23.75 13.20 14 392699 8232 55891122
Mean cell haemoglobin concentration abnormal 23.70 13.20 13 392700 105 55899249
Eyelid ptosis 23.58 13.20 8 392705 6511 55892843
Eye irritation 23.55 13.20 62 392651 18966 55880388
Intestinal sepsis 23.53 13.20 18 392695 269 55899085
Lipase increased 23.47 13.20 17 392696 8962 55890392
Bacterial infection 23.38 13.20 54 392659 17276 55882078
Fracture delayed union 23.23 13.20 51 392662 2302 55897052
Dental caries 23.18 13.20 22 392691 10146 55889208
Injection site hypersensitivity 23.18 13.20 45 392668 1860 55897494
Drug tolerance 23.16 13.20 93 392620 5901 55893453
Metastasis 23.15 13.20 3 392710 4781 55894573
Intermenstrual bleeding 23.13 13.20 10 392703 7017 55892337
Refusal of treatment by patient 23.07 13.20 4 392709 5134 55894220
Diabetic eye disease 23.02 13.20 14 392699 140 55899214
Asphyxia 22.95 13.20 6 392707 5783 55893571
Acute hepatic failure 22.90 13.20 51 392662 16527 55882827
Peritonitis bacterial 22.83 13.20 3 392710 4730 55894624
Accident 22.81 13.20 87 392626 5389 55893965
Dry throat 22.77 13.20 7 392706 6067 55893287
Illness 22.76 13.20 144 392569 34367 55864987
Blood pressure systolic decreased 22.57 13.20 8 392705 6335 55893019
Nail disorder 22.54 13.20 147 392566 11304 55888050
Anger 22.49 13.20 29 392684 11643 55887711
Menstrual disorder 22.46 13.20 3 392710 4672 55894682
Localised infection 22.42 13.20 291 392422 27121 55872233
Weight increased 22.37 13.20 1877 390836 227826 55671528
Choking 22.29 13.20 18 392695 8979 55890375
Needle issue 22.25 13.20 17 392696 8721 55890633
Metastases to lymph nodes 22.24 13.20 12 392701 7411 55891943
Impaired quality of life 22.21 13.20 16 392697 8458 55890896
Rash papular 22.12 13.20 37 392676 13346 55886008
Arteriosclerosis 22.09 13.20 20 392693 9433 55889921
Neck mass 22.03 13.20 63 392650 3357 55895997
Proteinuria 21.94 13.20 57 392656 17513 55881841
Middle lobe syndrome 21.91 13.20 9 392704 34 55899320
Product complaint 21.86 13.20 30 392683 11730 55887624
Osteomyelitis 21.86 13.20 263 392450 24083 55875271
Expired product administered 21.84 13.20 6 392707 5596 55893758
Systemic inflammatory response syndrome 21.84 13.20 5 392708 5273 55894081
Lung infiltration 21.78 13.20 39 392674 13699 55885655
Acne 21.76 13.20 75 392638 21061 55878293
Appendicitis 21.75 13.20 12 392701 7320 55892034
Large intestine perforation 21.68 13.20 14 392699 7837 55891517
Intracranial pressure increased 21.64 13.20 3 392710 4542 55894812
Pneumonia fungal 21.56 13.20 4 392709 4889 55894465
Hepatic ischaemia 21.52 13.20 24 392689 594 55898760
Sneezing 21.39 13.20 48 392665 15512 55883842
Congestive cardiomyopathy 21.29 13.20 7 392706 5812 55893542
Bronchopulmonary aspergillosis 21.15 13.20 16 392697 8248 55891106
Device leakage 21.10 13.20 9 392704 6366 55892988
Fungal infection 21.08 13.20 139 392574 32854 55866500
Blood alkaline phosphatase increased 21.07 13.20 172 392541 38773 55860581
Wrist fracture 21.06 13.20 32 392681 11994 55887360
Respiratory rate increased 21.01 13.20 33 392680 12204 55887150
Extrasystoles 20.98 13.20 4 392709 4795 55894559
Splenomegaly 20.93 13.20 24 392689 10144 55889210
Enteritis 20.92 13.20 13 392700 7430 55891924
Eye movement disorder 20.92 13.20 4 392709 4785 55894569
Limb operation 20.92 13.20 64 392649 3542 55895812
Activated partial thromboplastin time prolonged 20.84 13.20 10 392703 6602 55892752
Rales 20.82 13.20 27 392686 10813 55888541
Spinal meningioma benign 20.70 13.20 12 392701 109 55899245
Concomitant disease aggravated 20.69 13.20 17 392696 8409 55890945
Bone disorder 20.67 13.20 218 392495 19325 55880029
Dry mouth 20.66 13.20 319 392394 63886 55835468
Treatment noncompliance 20.56 13.20 138 392575 32485 55866869
Lyme disease 20.54 13.20 56 392657 2902 55896452
Brain natriuretic peptide increased 20.53 13.20 4 392709 4722 55894632
Embolism 20.51 13.20 13 392700 7351 55892003
Ear discomfort 20.50 13.20 12 392701 7083 55892271
Cardiac failure acute 20.46 13.20 19 392694 8854 55890500
Upper limb fracture 20.40 13.20 57 392656 17098 55882256
Limb injury 20.34 13.20 83 392630 22187 55877167
Osteonecrosis 20.28 13.20 88 392625 23127 55876227
Wound infection 20.28 13.20 178 392535 15015 55884339
Respiration abnormal 20.27 13.20 7 392706 5634 55893720
Dizziness postural 20.22 13.20 10 392703 6488 55892866
Aortic arteriosclerosis 20.21 13.20 7 392706 5623 55893731
Drug level below therapeutic 20.17 13.20 3 392710 4310 55895044
Forced expiratory volume decreased 20.13 13.20 4 392709 4656 55894698
Aortic valve incompetence 20.10 13.20 7 392706 5605 55893749
Blood potassium increased 20.05 13.20 58 392655 17203 55882151
Tumour marker increased 20.05 13.20 3 392710 4290 55895064
Vitreous floaters 19.84 13.20 7 392706 5560 55893794
Crohn's disease 19.83 13.20 10 392703 6417 55892937
Hyperammonaemia 19.81 13.20 5 392708 4935 55894419
Rheumatoid factor 19.66 13.20 10 392703 68 55899286
Lower limb fracture 19.65 13.20 199 392514 17456 55881898
Sinus congestion 19.64 13.20 51 392662 15673 55883681
Skin irritation 19.62 13.20 18 392695 8437 55890917
Rheumatic disorder 19.61 13.20 48 392665 2328 55897026
Hypertriglyceridaemia 19.59 13.20 8 392705 5808 55893546
Jaundice cholestatic 19.57 13.20 7 392706 5512 55893842
Arthritis bacterial 19.55 13.20 88 392625 5873 55893481
Abscess 19.55 13.20 48 392665 15033 55884321
International normalised ratio decreased 19.44 13.20 3 392710 4193 55895161
Post procedural complication 19.42 13.20 51 392662 15615 55883739
Bowel movement irregularity 19.29 13.20 4 392709 4519 55894835
Metabolic disorder 19.24 13.20 7 392706 5454 55893900
Red blood cell count decreased 19.23 13.20 163 392550 36454 55862900
Invasive ductal breast carcinoma 19.08 13.20 12 392701 6814 55892540
Odynophagia 19.04 13.20 12 392701 6806 55892548
Infusion site pruritus 19.02 13.20 5 392708 4802 55894552
Supraventricular extrasystoles 18.96 13.20 3 392710 4117 55895237
Micturition urgency 18.87 13.20 20 392693 8761 55890593
Hepatomegaly 18.80 13.20 31 392682 11244 55888110
Hypertonia 18.79 13.20 3 392710 4089 55895265
Internal haemorrhage 18.77 13.20 5 392708 4759 55894595
Hypovolaemic shock 18.74 13.20 7 392706 5366 55893988
Diffuse large B-cell lymphoma 18.71 13.20 13 392700 7003 55892351
Stillbirth 18.69 13.20 10 392703 6204 55893150
Diastolic dysfunction 18.63 13.20 8 392705 5637 55893717
Cellulitis gangrenous 18.61 13.20 9 392704 54 55899300
Drug-induced liver injury 18.61 13.20 341 392372 34121 55865233
Live birth 18.58 13.20 214 392499 19391 55879963
Hepatic fibrosis 18.49 13.20 58 392655 3254 55896100
Urine analysis abnormal 18.49 13.20 5 392708 4712 55894642
Rash maculo-papular 18.36 13.20 122 392591 28785 55870569
Hepatic enzyme abnormal 18.35 13.20 78 392635 5077 55894277
Ocular toxicity 18.35 13.20 23 392690 646 55898708
Drug level above therapeutic 18.32 13.20 4 392709 4358 55894996
Serum ferritin increased 18.19 13.20 8 392705 5557 55893797
Cholecystitis acute 18.17 13.20 15 392698 7401 55891953
Chronic sinusitis 18.10 13.20 19 392694 8359 55890995
Orthopnoea 18.02 13.20 9 392704 5807 55893547
Vitamin D deficiency 18.02 13.20 36 392677 12134 55887220
Pneumothorax 17.98 13.20 49 392664 14818 55884536
Uterine leiomyoma 17.93 13.20 19 392694 8323 55891031
Soft tissue swelling 17.92 13.20 29 392684 1036 55898318
Diverticulum 17.92 13.20 31 392682 11035 55888319
Humerus fracture 17.90 13.20 18 392695 8079 55891275
Incorrect dosage administered 17.89 13.20 39 392674 1752 55897602
Glucose tolerance impaired 17.86 13.20 8 392705 5497 55893857
Eye pruritus 17.80 13.20 46 392667 14160 55885194
Spinal fracture 17.79 13.20 57 392656 16367 55882987
Drug use disorder 17.69 13.20 72 392641 4597 55894757
Affect lability 17.67 13.20 27 392686 10098 55889256
Polyuria 17.61 13.20 16 392697 7535 55891819
Overwork 17.59 13.20 9 392704 62 55899292
Salt craving 17.51 13.20 10 392703 88 55899266
Breast pain 17.42 13.20 18 392695 7976 55891378
Laboratory test abnormal 17.35 13.20 101 392612 24594 55874760
Ileus paralytic 17.31 13.20 4 392709 4191 55895163
Exposure during pregnancy 17.30 13.20 1138 391575 135204 55764150
Blood glucose abnormal 17.24 13.20 15 392698 7213 55892141
Bronchospasm 17.23 13.20 54 392659 15615 55883739
Bladder cancer 17.23 13.20 6 392707 4804 55894550
Heart rate abnormal 17.23 13.20 5 392708 4498 55894856
Colon cancer 17.17 13.20 25 392688 9536 55889818
Pain of skin 17.16 13.20 21 392692 8625 55890729
Maternal drugs affecting foetus 17.16 13.20 7 392706 5086 55894268
Urine abnormality 17.10 13.20 13 392700 6686 55892668
Gastroenteritis 17.07 13.20 100 392613 24312 55875042
Steatohepatitis 17.04 13.20 19 392694 470 55898884
Enterococcal infection 17.03 13.20 15 392698 7169 55892185
Enthesophyte 17.01 13.20 6 392707 13 55899341
Premature rupture of membranes 16.97 13.20 6 392707 4759 55894595
Ventricular septal defect 16.96 13.20 4 392709 4134 55895220
Product residue present 16.94 13.20 3 392710 3792 55895562
Skin burning sensation 16.88 13.20 32 392681 10999 55888355
Spinal cord compression 16.88 13.20 3 392710 3781 55895573
Scratch 16.87 13.20 9 392704 5594 55893760
Decreased activity 16.84 13.20 9 392704 5587 55893767
Paralysis 16.83 13.20 23 392690 9009 55890345
Gingival pain 16.82 13.20 12 392701 6376 55892978
Cardiac tamponade 16.78 13.20 5 392708 4421 55894933
Hydronephrosis 16.76 13.20 24 392689 9218 55890136
Photopsia 16.75 13.20 4 392709 4099 55895255
Prescribed overdose 16.71 13.20 233 392480 22063 55877291
Amyotrophic lateral sclerosis 16.70 13.20 29 392684 1099 55898255
Visual field defect 16.62 13.20 11 392702 6078 55893276
Ketoacidosis 16.59 13.20 4 392709 4071 55895283
Dermatitis bullous 16.56 13.20 17 392696 7556 55891798
Middle insomnia 16.55 13.20 32 392681 10918 55888436
Muscle relaxant therapy 16.52 13.20 12 392701 165 55899189
Haemolysis 16.52 13.20 12 392701 6316 55893038
Pseudomonas infection 16.50 13.20 28 392685 10043 55889311
Tendonitis 16.47 13.20 196 392517 17901 55881453
Bladder disorder 16.45 13.20 19 392694 8005 55891349
Blood culture positive 16.31 13.20 5 392708 4341 55895013
Intervertebral disc space narrowing 16.27 13.20 26 392687 919 55898435
Facet joint syndrome 16.26 13.20 91 392622 6626 55892728
Breast cancer female 16.20 13.20 39 392674 12299 55887055
C-reactive protein 16.10 13.20 40 392673 1959 55897395
Arteriospasm coronary 16.03 13.20 3 392710 3644 55895710
Maternal exposure during breast feeding 16.03 13.20 3 392710 3644 55895710
Multiple-drug resistance 15.98 13.20 4 392709 3970 55895384
Oxygen consumption increased 15.93 13.20 3 392710 3628 55895726
Transplant rejection 15.93 13.20 28 392685 9906 55889448
Drug dependence 15.92 13.20 92 392621 22441 55876913
Catheterisation cardiac 15.90 13.20 5 392708 4270 55895084
Deep vein thrombosis postoperative 15.85 13.20 63 392650 3978 55895376
Immune reconstitution inflammatory syndrome 15.83 13.20 10 392703 5664 55893690
Oral mucosal blistering 15.83 13.20 8 392705 5126 55894228
Haemorrhagic stroke 15.80 13.20 9 392704 5394 55893960
Inflammatory marker increased 15.75 13.20 84 392629 6006 55893348
Snoring 15.62 13.20 3 392710 3578 55895776
Gallbladder disorder 15.58 13.20 65 392648 17269 55882085
Maternal exposure timing unspecified 15.55 13.20 77 392636 5346 55894008
Injection site bruising 15.43 13.20 183 392530 38338 55861016
Abnormal faeces 15.35 13.20 7 392706 4761 55894593
Hepatic necrosis 15.34 13.20 9 392704 5307 55894047
Culture urine positive 15.30 13.20 3 392710 3525 55895829
Dermatitis exfoliative 15.25 13.20 9 392704 5290 55894064
Blood thyroid stimulating hormone increased 15.20 13.20 14 392699 6549 55892805
Anxiety disorder 15.06 13.20 4 392709 3816 55895538
Thrombophlebitis 15.04 13.20 5 392708 4122 55895232
Mass 15.02 13.20 43 392670 12796 55886558
Stress at work 15.00 13.20 28 392685 1123 55898231
Tooth extraction 15.00 13.20 27 392686 9466 55889888
Bacterial test positive 14.93 13.20 8 392705 4960 55894394
Retinal haemorrhage 14.93 13.20 7 392706 4684 55894670
Drug screen positive 14.91 13.20 3 392710 3461 55895893
Feeling drunk 14.90 13.20 4 392709 3788 55895566
Foetal death 14.89 13.20 23 392690 8564 55890790
Viral upper respiratory tract infection 14.89 13.20 94 392619 7148 55892206
Eczema 14.85 13.20 114 392599 26039 55873315
Loss of employment 14.80 13.20 38 392675 1899 55897455
SARS-CoV-2 test positive 14.77 13.20 13 392700 6216 55893138
Breast cancer recurrent 14.74 13.20 5 392708 4070 55895284
Thrombotic microangiopathy 14.67 13.20 27 392686 9384 55889970
Hepatic cirrhosis 14.66 13.20 219 392494 21044 55878310
Large intestine polyp 14.64 13.20 19 392694 7608 55891746
Parotid gland enlargement 14.64 13.20 23 392690 801 55898553
Aplasia pure red cell 14.58 13.20 6 392707 4336 55895018
Pleural thickening 14.57 13.20 47 392666 2676 55896678
Trigeminal neuralgia 14.56 13.20 3 392710 3404 55895950
Facial paralysis 14.55 13.20 46 392667 13265 55886089
Abdominal hernia 14.54 13.20 7 392706 4612 55894742
Pyelonephritis acute 14.51 13.20 6 392707 4323 55895031
Ammonia increased 14.51 13.20 6 392707 4323 55895031
Blepharospasm 14.51 13.20 3 392710 3395 55895959
Arterial occlusive disease 14.46 13.20 10 392703 5400 55893954
Granuloma 14.40 13.20 76 392637 5411 55893943
Brain herniation 14.40 13.20 3 392710 3377 55895977
Road traffic accident 14.36 13.20 125 392588 27802 55871552
Atypical pneumonia 14.36 13.20 5 392708 4003 55895351
Gingival swelling 14.34 13.20 5 392708 4001 55895353
Malignant neoplasm of conjunctiva 14.34 13.20 7 392706 43 55899311
Venous thrombosis 14.32 13.20 7 392706 4573 55894781
Facial bones fracture 14.32 13.20 3 392710 3364 55895990
Tongue oedema 14.26 13.20 5 392708 3987 55895367
Intervertebral disc compression 14.23 13.20 25 392688 956 55898398
Pain in extremity 14.23 13.20 2322 390391 295109 55604245
Pelvic fracture 14.22 13.20 41 392672 12172 55887182
Escherichia urinary tract infection 14.17 13.20 35 392678 10940 55888414
Formication 14.14 13.20 5 392708 3965 55895389
Bunion operation 14.10 13.20 28 392685 1177 55898177
Skin tightness 14.05 13.20 5 392708 3950 55895404
Spinal fusion surgery 14.03 13.20 65 392648 4391 55894963
Aphonia 13.99 13.20 26 392687 9003 55890351
Breast mass 13.98 13.20 17 392696 7002 55892352
Catheter site infection 13.97 13.20 7 392706 4507 55894847
Amnesia 13.95 13.20 233 392480 46089 55853265
Breast cyst excision 13.95 13.20 8 392705 71 55899283
Lung consolidation 13.93 13.20 5 392708 3929 55895425
Neutrophilia 13.93 13.20 5 392708 3928 55895426
Lupus vulgaris 13.88 13.20 37 392676 1892 55897462
Stridor 13.88 13.20 3 392710 3292 55896062
Female genital tract fistula 13.85 13.20 7 392706 4485 55894869
Bundle branch block right 13.75 13.20 8 392705 4739 55894615
Renal pain 13.72 13.20 13 392700 6000 55893354
Coronary artery stenosis 13.72 13.20 7 392706 4461 55894893
Hyperpyrexia 13.72 13.20 3 392710 3265 55896089
Galactorrhoea 13.71 13.20 5 392708 3890 55895464
Hair texture abnormal 13.69 13.20 5 392708 3887 55895467
Intestinal ischaemia 13.69 13.20 17 392696 6938 55892416
Hydrocephalus 13.63 13.20 9 392704 4980 55894374
Tongue disorder 13.61 13.20 118 392595 9918 55889436
Diverticulum oesophageal 13.56 13.20 10 392703 141 55899213
Off label use 13.54 13.20 4207 388506 551973 55347381
Polydipsia 13.52 13.20 3 392710 3232 55896122
Portal hypertension 13.42 13.20 4 392709 3537 55895817
Uterine haemorrhage 13.42 13.20 4 392709 3536 55895818
Hepatic cancer 13.38 13.20 6 392707 4121 55895233
Blood urine present 13.35 13.20 49 392664 13506 55885848
Sluggishness 13.34 13.20 8 392705 4660 55894694
Acute hepatitis C 13.32 13.20 8 392705 78 55899276
Dysaesthesia 13.32 13.20 6 392707 4110 55895244
Injection site nodule 13.29 13.20 4 392709 3515 55895839
Paradoxical drug reaction 13.28 13.20 5 392708 3815 55895539
Impaired driving ability 13.21 13.20 6 392707 4090 55895264

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 2635.75 15.02 1438 58962 46371 31590573
Drug ineffective 2300.02 15.02 3246 57154 392327 31244617
Joint swelling 1568.41 15.02 1075 59325 52356 31584588
Drug intolerance 1508.52 15.02 1039 59361 50994 31585950
Contraindicated product administered 913.59 15.02 531 59869 19241 31617703
Treatment failure 760.13 15.02 626 59774 40166 31596778
Synovitis 692.45 15.02 376 60024 11907 31625037
C-reactive protein abnormal 679.07 15.02 320 60080 7449 31629495
Apparent death 595.38 15.02 233 60167 3372 31633572
Arthralgia 568.65 15.02 1026 59374 150398 31486546
Arthropathy 537.53 15.02 411 59989 23640 31613304
Musculoskeletal stiffness 509.99 15.02 503 59897 40822 31596122
Bone erosion 506.34 15.02 204 60196 3199 31633745
Therapeutic product effect decreased 492.26 15.02 438 59962 31184 31605760
Pain 472.49 15.02 1074 59326 185685 31451259
Diverticulitis 441.74 15.02 330 60070 18315 31618629
Red blood cell sedimentation rate abnormal 438.74 15.02 178 60222 2844 31634100
Drug hypersensitivity 407.24 15.02 591 59809 72008 31564936
Psoriatic arthropathy 363.36 15.02 302 60098 19581 31617363
Drug eruption 321.47 15.02 271 60129 17916 31619028
Loss of personal independence in daily activities 318.84 15.02 328 60072 27960 31608984
Urticaria 297.57 15.02 451 59949 57066 31579878
Mobility decreased 288.97 15.02 307 60093 27162 31609782
Stomatitis 271.98 15.02 355 60045 39083 31597861
Pain in extremity 268.60 15.02 646 59754 115557 31521387
Death 266.77 15.02 181 60219 360388 31276556
Red blood cell sedimentation rate increased 265.62 15.02 177 60223 8169 31628775
Hand deformity 264.60 15.02 125 60275 2922 31634022
C-reactive protein increased 248.07 15.02 379 60021 48271 31588673
Hypotension 218.52 15.02 60 60340 204558 31432386
Sleep disorder due to general medical condition, insomnia type 215.09 15.02 84 60316 1207 31635737
Hypersensitivity 215.06 15.02 383 60017 55360 31581584
Disability 214.53 15.02 125 60275 4536 31632408
Arthritis 208.48 15.02 259 60141 27126 31609818
Febrile neutropenia 197.66 15.02 8 60392 121841 31515103
Impaired work ability 190.29 15.02 126 60274 5751 31631193
Acute kidney injury 189.00 15.02 154 60246 279560 31357384
Therapeutic product effect incomplete 186.50 15.02 314 60086 43382 31593562
Rheumatoid factor negative 183.37 15.02 67 60333 792 31636152
Rheumatoid nodule 176.24 15.02 91 60309 2590 31634354
Alanine aminotransferase abnormal 173.67 15.02 103 60297 3864 31633080
Anti-cyclic citrullinated peptide antibody positive 170.29 15.02 73 60327 1347 31635597
Limb discomfort 169.38 15.02 147 60253 10102 31626842
Peripheral swelling 168.18 15.02 388 60012 67477 31569467
Knee arthroplasty 164.04 15.02 120 60280 6438 31630506
Pulmonary thrombosis 163.27 15.02 122 60278 6763 31630181
Anaemia 161.77 15.02 104 60296 213418 31423526
Chondropathy 159.50 15.02 62 60338 879 31636065
Gastrointestinal disorder 152.17 15.02 236 60164 30424 31606520
Bone cyst 150.24 15.02 63 60337 1098 31635846
Osteoarthritis 149.38 15.02 183 60217 18884 31618060
Confusional state 148.12 15.02 36 60364 133298 31503646
Toxicity to various agents 147.84 15.02 81 60319 181406 31455538
Tenosynovitis 145.43 15.02 94 60306 4116 31632828
Enthesopathy 141.43 15.02 93 60307 4194 31632750
Drug tolerance decreased 139.05 15.02 68 60332 1719 31635225
Onychoclasis 138.76 15.02 68 60332 1727 31635217
Lymphoma 138.12 15.02 135 60265 10808 31626136
Swelling 138.02 15.02 252 60148 37106 31599838
Terminal state 136.25 15.02 86 60314 3612 31633332
Drug interaction 135.54 15.02 119 60281 208424 31428520
Malignant neoplasm progression 132.20 15.02 4 60396 78994 31557950
Constipation 127.34 15.02 39 60361 123952 31512992
Atlantoaxial instability 125.00 15.02 40 60360 305 31636639
Dehydration 124.99 15.02 36 60364 119075 31517869
Spinal instability 122.79 15.02 40 60360 325 31636619
Herpes zoster 122.23 15.02 219 60181 31774 31605170
Mineral metabolism disorder 122.04 15.02 40 60360 332 31636612
Joint ankylosis 121.25 15.02 53 60347 1027 31635917
Hepatic function abnormal 120.56 15.02 252 60148 40970 31595974
Thrombocytopenia 118.70 15.02 62 60338 142685 31494259
Dislocation of vertebra 115.81 15.02 40 60360 396 31636548
Sarcoidosis 114.39 15.02 69 60331 2670 31634274
Acne cystic 113.41 15.02 41 60359 469 31636475
Overdose 113.29 15.02 14 60386 84650 31552294
Drug specific antibody present 111.53 15.02 69 60331 2796 31634148
Inflammation 111.13 15.02 184 60216 25057 31611887
Dizziness 107.54 15.02 133 60267 199014 31437930
Intervertebral disc space narrowing 104.60 15.02 46 60354 905 31636039
Rhabdomyolysis 103.63 15.02 4 60396 63577 31573367
Tooth loss 102.24 15.02 72 60328 3636 31633308
Alopecia 100.85 15.02 158 60242 20537 31616407
Pyrexia 100.01 15.02 275 60125 303565 31333379
Tongue disorder 97.44 15.02 79 60321 4938 31632006
Vomiting 94.52 15.02 177 60223 223796 31413148
Decreased appetite 92.89 15.02 93 60307 153124 31483820
Joint arthroplasty 92.13 15.02 40 60360 762 31636182
Seizure 91.12 15.02 38 60362 99730 31537214
Osteolysis 90.74 15.02 56 60344 2259 31634685
Bradycardia 89.08 15.02 13 60387 69314 31567630
Hyperkalaemia 87.66 15.02 10 60390 64341 31572603
Rheumatoid factor positive 87.60 15.02 37 60363 657 31636287
Joint stiffness 86.39 15.02 101 60299 9920 31627024
Neutropenia 85.30 15.02 85 60315 140279 31496665
Hip arthroplasty 85.18 15.02 67 60333 4008 31632936
Pulmonary fibrosis 85.10 15.02 130 60270 16530 31620414
Somnolence 84.39 15.02 42 60358 99403 31537541
Fall 82.11 15.02 143 60257 185946 31450998
Epistaxis 81.26 15.02 256 60144 53451 31583493
Infection 79.47 15.02 338 60062 81593 31555351
Disease progression 78.60 15.02 37 60363 90427 31546517
Osteosclerosis 78.60 15.02 41 60359 1192 31635752
Foot deformity 77.77 15.02 64 60336 4085 31632859
Agitation 77.46 15.02 7 60393 54162 31582782
Musculoskeletal discomfort 76.47 15.02 80 60320 6943 31630001
Plasma cell myeloma 76.46 15.02 9 60391 56522 31580422
Cardiac arrest 74.99 15.02 38 60362 89024 31547920
Ill-defined disorder 74.14 15.02 105 60295 12472 31624472
Tooth fracture 74.06 15.02 57 60343 3302 31633642
Intestinal sepsis 73.78 15.02 31 60369 543 31636401
End stage renal disease 73.71 15.02 84 60316 8025 31628919
Cytology abnormal 73.67 15.02 28 60372 372 31636572
Liver function test increased 73.26 15.02 105 60295 12609 31624335
Drug use disorder 71.67 15.02 60 60340 3923 31633021
Nodule 71.42 15.02 70 60330 5620 31631324
Gait inability 70.49 15.02 129 60271 19015 31617929
Muscle spasms 70.27 15.02 287 60113 68031 31568913
Atrial fibrillation 67.86 15.02 70 60330 113713 31523231
Photosensitivity reaction 66.40 15.02 88 60312 9816 31627128
Intentional overdose 66.11 15.02 3 60397 41386 31595558
Joint range of motion decreased 65.69 15.02 72 60328 6589 31630355
Tendonitis 65.17 15.02 81 60319 8477 31628467
International normalised ratio increased 64.24 15.02 6 60394 45217 31591727
Joint lock 63.56 15.02 35 60365 1137 31635807
Haemorrhage 62.87 15.02 8 60392 47326 31589618
Deep vein thrombosis 62.34 15.02 255 60145 60481 31576463
Platelet count decreased 61.37 15.02 72 60328 110363 31526581
Hyponatraemia 61.35 15.02 32 60368 73767 31563177
Seronegative arthritis 60.92 15.02 32 60368 944 31636000
Hypokalaemia 60.34 15.02 14 60386 53560 31583384
Cardiac failure congestive 59.51 15.02 39 60361 79348 31557596
Skin ulcer 59.35 15.02 123 60277 19862 31617082
Abdominal pain 59.16 15.02 118 60282 145834 31491110
Suicide attempt 58.52 15.02 3 60397 37245 31599699
Tachycardia 57.72 15.02 37 60363 76170 31560774
Syncope 57.18 15.02 47 60353 85135 31551809
Polyomavirus-associated nephropathy 56.58 15.02 50 60350 3518 31633426
Ankle deformity 56.27 15.02 20 60380 217 31636727
Mental status changes 56.19 15.02 3 60397 35965 31600979
Localised infection 55.11 15.02 102 60298 15163 31621781
Hallucination 54.56 15.02 11 60389 46399 31590545
Mass 52.04 15.02 67 60333 7264 31629680
Pneumonia aspiration 50.34 15.02 7 60393 38719 31598225
Skin laceration 50.06 15.02 83 60317 11308 31625636
Dyspnoea 49.09 15.02 419 59981 343060 31293884
Prerenal failure 48.82 15.02 35 60365 1818 31635126
Hypoglycaemia 48.80 15.02 18 60382 50928 31586016
Blood glucose increased 48.57 15.02 28 60372 61055 31575889
Myalgia 47.79 15.02 46 60354 77212 31559732
Exposure via body fluid 47.62 15.02 15 60385 108 31636836
Fine motor skill dysfunction 47.02 15.02 33 60367 1657 31635287
Neutrophil count decreased 46.84 15.02 15 60385 46379 31590565
Electrocardiogram QT prolonged 46.80 15.02 8 60392 37979 31598965
Musculoskeletal pain 46.77 15.02 144 60256 29684 31607260
Hyperglycaemia 46.47 15.02 7 60393 36469 31600475
Musculoskeletal disorder 46.38 15.02 56 60344 5688 31631256
Ankylosing spondylitis 45.32 15.02 56 60344 5825 31631119
Cardio-respiratory arrest 45.15 15.02 21 60379 51705 31585239
Oral surgery 44.88 15.02 22 60378 559 31636385
Therapeutic response decreased 44.41 15.02 131 60269 26378 31610566
Delirium 44.36 15.02 12 60388 41409 31595535
Physical disability 44.12 15.02 29 60371 1306 31635638
Joint effusion 44.12 15.02 49 60351 4550 31632394
Diabetes mellitus 43.91 15.02 179 60221 42377 31594567
Urinary tract infection 43.90 15.02 49 60351 76820 31560124
Soft tissue swelling 43.66 15.02 19 60381 364 31636580
Tuberculin test positive 43.55 15.02 27 60373 1098 31635846
Abdominal discomfort 43.37 15.02 204 60196 51363 31585581
Loss of consciousness 42.35 15.02 51 60349 77304 31559640
Grip strength decreased 41.80 15.02 37 60363 2609 31634335
Blood creatine phosphokinase increased 41.62 15.02 14 60386 41960 31594984
Pulmonary mass 41.38 15.02 76 60324 11230 31625714
Granuloma 40.61 15.02 38 60362 2879 31634065
Product dose omission issue 39.71 15.02 89 60311 105497 31531447
Hospitalisation 39.35 15.02 23 60377 49784 31587160
Skin mass 39.04 15.02 41 60359 3573 31633371
Rheumatoid lung 39.04 15.02 22 60378 748 31636196
Cerebrovascular accident 38.83 15.02 57 60343 79427 31557517
Interstitial lung disease 38.57 15.02 224 60176 61179 31575765
Hepatic cirrhosis 38.07 15.02 89 60311 15585 31621359
Pulmonary embolism 37.92 15.02 276 60124 81370 31555574
Medical device implantation 37.77 15.02 20 60380 600 31636344
Immobile 37.28 15.02 33 60367 2327 31634617
Liver disorder 37.27 15.02 133 60267 29574 31607370
Respiratory failure 36.95 15.02 87 60313 101362 31535582
Dysarthria 36.78 15.02 8 60392 32009 31604935
Lactic acidosis 36.65 15.02 8 60392 31929 31605015
X-ray abnormal 36.62 15.02 18 60382 460 31636484
Finger deformity 36.62 15.02 25 60375 1200 31635744
Abdominal distension 36.50 15.02 26 60374 50658 31586286
Tooth disorder 36.18 15.02 67 60333 9962 31626982
Haematuria 35.73 15.02 22 60378 46292 31590652
Flushing 35.70 15.02 7 60393 30121 31606823
Urinary retention 35.68 15.02 10 60390 33715 31603229
Red blood cell sedimentation rate 35.45 15.02 23 60377 1013 31635931
Intentional product misuse 35.36 15.02 14 60386 37937 31599007
Dactylitis 34.59 15.02 21 60379 822 31636122
Hepatic enzyme abnormal 34.52 15.02 32 60368 2396 31634548
Multiple organ dysfunction syndrome 34.21 15.02 48 60352 68155 31568789
Granuloma skin 33.61 15.02 23 60377 1108 31635836
Pyopneumothorax 33.59 15.02 10 60390 58 31636886
Gastrointestinal haemorrhage 33.19 15.02 67 60333 82482 31554462
Suicidal ideation 32.99 15.02 14 60386 36392 31600552
Intentional product use issue 32.95 15.02 183 60217 49164 31587780
Unresponsive to stimuli 32.75 15.02 5 60395 25795 31611149
Septic shock 32.75 15.02 47 60353 66111 31570833
Hypoxia 32.23 15.02 29 60371 50284 31586660
Limb deformity 31.74 15.02 17 60383 522 31636422
Metabolic acidosis 31.66 15.02 18 60382 39559 31597385
Renal impairment 31.48 15.02 74 60326 86275 31550669
Coronary artery disease 31.44 15.02 25 60375 46062 31590882
Coma 31.12 15.02 20 60380 41130 31595814
Blood pressure decreased 30.47 15.02 28 60372 48063 31588881
Blood parathyroid hormone decreased 30.39 15.02 23 60377 1299 31635645
Blood creatinine increased 30.39 15.02 79 60321 88999 31547945
Respiratory distress 30.25 15.02 13 60387 33540 31603404
Depressed level of consciousness 30.24 15.02 18 60382 38583 31598361
Pancreatitis acute 30.22 15.02 6 60394 25594 31611350
Product use in unapproved indication 30.11 15.02 93 60307 99078 31537866
Polyarthritis 28.84 15.02 38 60362 4214 31632730
Food intolerance 28.68 15.02 22 60378 1268 31635676
Intestinal obstruction 28.57 15.02 3 60397 20607 31616337
Hypocalcaemia 28.50 15.02 4 60396 21974 31614970
Stent placement 28.49 15.02 40 60360 4711 31632233
Oral disorder 28.04 15.02 36 60364 3891 31633053
Oedema 27.91 15.02 24 60376 42537 31594407
Speech disorder 27.89 15.02 6 60394 24195 31612749
Asthenia 27.78 15.02 284 60116 224471 31412473
Lymphoedema 27.75 15.02 34 60366 3506 31633438
Dysphagia 27.54 15.02 42 60358 57634 31579310
Respiratory arrest 27.38 15.02 8 60392 26249 31610695
Lacrimal disorder 27.27 15.02 13 60387 310 31636634
Human polyomavirus infection 27.23 15.02 17 60383 700 31636244
COVID-19 27.07 15.02 39 60361 54782 31582162
Fatigue 27.02 15.02 463 59937 334743 31302201
Fibromyalgia 26.92 15.02 30 60370 2796 31634148
Chest pain 26.84 15.02 123 60277 116834 31520110
Exostosis 26.77 15.02 35 60365 3851 31633093
Toxic epidermal necrolysis 26.66 15.02 3 60397 19521 31617423
Hepatic enzyme increased 26.58 15.02 137 60263 35771 31601173
Neoplasm malignant 26.57 15.02 88 60312 18843 31618101
Cardiac failure 26.52 15.02 80 60320 85873 31551071
Condition aggravated 26.37 15.02 449 59951 163560 31473384
Blood cholesterol abnormal 26.22 15.02 23 60377 1602 31635342
Panniculitis 26.17 15.02 24 60376 1772 31635172
Disorientation 26.03 15.02 13 60387 30731 31606213
Hepatic steatosis 26.01 15.02 79 60321 16160 31620784
Wrist deformity 25.76 15.02 13 60387 352 31636592
Irritability 25.73 15.02 6 60394 22883 31614061
Subdural haematoma 25.69 15.02 3 60397 18968 31617976
Foetal exposure during pregnancy 25.66 15.02 24 60376 40852 31596092
Cytomegalovirus viraemia 25.61 15.02 46 60354 6679 31630265
Wrong technique in product usage process 25.49 15.02 16 60384 33327 31603617
Shoulder operation 25.19 15.02 18 60382 930 31636014
Chills 25.10 15.02 66 60334 74084 31562860
Generalised tonic-clonic seizure 24.99 15.02 4 60396 19927 31617017
Neck pain 24.93 15.02 98 60302 22812 31614132
Dysgeusia 24.75 15.02 7 60393 23459 31613485
Pulmonary toxicity 24.73 15.02 40 60360 5337 31631607
Restlessness 24.58 15.02 7 60393 23354 31613590
Renal failure 24.53 15.02 350 60050 122980 31513964
Thrombosis 24.12 15.02 158 60242 44993 31591951
Haematoma 24.02 15.02 8 60392 24131 31612813
Aortic bruit 23.86 15.02 10 60390 174 31636770
Bursitis 23.85 15.02 38 60362 5007 31631937
Surgery 23.76 15.02 65 60335 12534 31624410
Heart block congenital 23.75 15.02 7 60393 39 31636905
Vasculitic rash 23.71 15.02 17 60383 883 31636061
Splenic embolism 23.50 15.02 10 60390 181 31636763
Diarrhoea 23.42 15.02 503 59897 351906 31285038
Cerebral haemorrhage 23.40 15.02 17 60383 32795 31604149
Elbow operation 23.38 15.02 9 60391 124 31636820
White blood cell count increased 23.21 15.02 24 60376 38976 31597968
Cutaneous symptom 22.78 15.02 11 60389 270 31636674
Epilepsy 22.71 15.02 6 60394 21035 31615909
Injury 22.48 15.02 5 60395 19704 31617240
Alanine aminotransferase increased 22.34 15.02 229 60171 74427 31562517
Accidental overdose 22.30 15.02 4 60396 18346 31618598
Orthostatic hypotension 22.30 15.02 9 60391 24110 31612834
Pulmonary cavitation 22.18 15.02 16 60384 839 31636105
Tooth extraction 22.14 15.02 34 60366 4341 31632603
Acute respiratory failure 22.09 15.02 13 60387 28042 31608902
Melaena 21.91 15.02 18 60382 32636 31604308
Ventricular tachycardia 21.66 15.02 9 60391 23692 31613252
Unevaluable event 21.60 15.02 16 60384 30559 31606385
Sideroblastic anaemia 21.59 15.02 10 60390 223 31636721
Full blood count decreased 21.47 15.02 3 60397 16537 31620407
Blood pressure fluctuation 21.39 15.02 93 60307 22643 31614301
Gastric disorder 21.27 15.02 59 60341 11469 31625475
Arrhythmia 21.26 15.02 19 60381 33058 31603886
Impaired healing 21.01 15.02 67 60333 14065 31622879
Therapy non-responder 20.99 15.02 123 60277 33688 31603256
Histoplasmosis 20.87 15.02 19 60381 1390 31635554
Cytomegalovirus syndrome 20.87 15.02 8 60392 109 31636835
Soft tissue inflammation 20.66 15.02 7 60393 65 31636879
Ossicle disorder 20.58 15.02 6 60394 32 31636912
C-reactive protein decreased 20.34 15.02 21 60379 1794 31635150
Hypertension 20.32 15.02 350 60050 127750 31509194
Arthrodesis 20.28 15.02 12 60388 448 31636496
Steatorrhoea 20.18 15.02 14 60386 690 31636254
Rash maculo-papular 20.14 15.02 12 60388 25707 31611237
Hypervolaemia 20.09 15.02 5 60395 18246 31618698
Spina bifida occulta 19.95 15.02 5 60395 13 31636931
Diaphragmatic injury 19.70 15.02 8 60392 128 31636816
Drug reaction with eosinophilia and systemic symptoms 19.59 15.02 17 60383 30001 31606943
Arthritis bacterial 19.57 15.02 33 60367 4557 31632387
Lethargy 19.56 15.02 27 60373 38614 31598330
Head injury 19.46 15.02 4 60396 16654 31620290
Cell-mediated cytotoxicity 19.45 15.02 6 60394 40 31636904
Retinal scar 19.45 15.02 10 60390 282 31636662
Diffuse idiopathic skeletal hyperostosis 19.45 15.02 6 60394 40 31636904
Dermatitis psoriasiform 19.39 15.02 17 60383 1183 31635761
Hepatotoxicity 19.36 15.02 80 60320 19046 31617898
Vitamin B1 decreased 19.35 15.02 10 60390 285 31636659
Latent tuberculosis 19.10 15.02 17 60383 1207 31635737
Fracture 19.05 15.02 39 60361 6241 31630703
Full blood count abnormal 18.95 15.02 4 60396 16343 31620601
Fear of injection 18.78 15.02 17 60383 1234 31635710
Cartilage injury 18.77 15.02 12 60388 515 31636429
Chronic kidney disease 18.76 15.02 27 60373 37948 31598996
Ejection fraction decreased 18.76 15.02 5 60395 17429 31619515
Vision blurred 18.62 15.02 32 60368 41883 31595061
Lymphocyte count decreased 18.61 15.02 8 60392 20641 31616303
Ascites 18.51 15.02 31 60369 40982 31595962
Joint injury 18.47 15.02 44 60356 7797 31629147
Cardiac granuloma 18.30 15.02 4 60396 4 31636940
Paternal drugs affecting foetus 18.08 15.02 6 60394 52 31636892
Erectile dysfunction 18.07 15.02 7 60393 19228 31617716
Memory impairment 17.98 15.02 28 60372 38102 31598842
Oral pustule 17.89 15.02 9 60391 242 31636702
Psoriasis 17.84 15.02 151 60249 46568 31590376
Altered state of consciousness 17.67 15.02 9 60391 21042 31615902
Motor dysfunction 17.64 15.02 38 60362 6301 31630643
Nail pitting 17.63 15.02 9 60391 250 31636694
Erythema elevatum diutinum 17.58 15.02 5 60395 24 31636920
Erythema 17.52 15.02 232 60168 80173 31556771
Shoulder arthroplasty 17.51 15.02 11 60389 458 31636486
Fluid retention 17.49 15.02 13 60387 24789 31612155
Pulmonary granuloma 17.40 15.02 17 60383 1359 31635585
Anaphylactic shock 17.37 15.02 3 60397 14142 31622802
Otospondylomegaepiphyseal dysplasia 17.35 15.02 7 60393 110 31636834
Blood bilirubin increased 17.34 15.02 25 60375 35111 31601833
Haematocrit decreased 17.33 15.02 19 60381 30042 31606902
Drug withdrawal syndrome 17.33 15.02 7 60393 18743 31618201
Medication error 17.31 15.02 11 60389 22761 31614183
Hernia pain 17.18 15.02 9 60391 264 31636680
Dental caries 17.13 15.02 30 60370 4271 31632673
Product administration error 17.13 15.02 4 60396 15243 31621701
Ileus 17.00 15.02 4 60396 15165 31621779
Dysphonia 16.99 15.02 9 60391 20582 31616362
Carditis 16.97 15.02 8 60392 186 31636758
C-reactive protein 16.90 15.02 7 60393 118 31636826
Disturbance in attention 16.85 15.02 11 60389 22439 31614505
Emphysema 16.81 15.02 46 60354 8872 31628072
Enzyme abnormality 16.66 15.02 8 60392 194 31636750
Exposure via father 16.64 15.02 7 60393 123 31636821
Cerebral infarction 16.60 15.02 15 60385 25962 31610982
Gastritis 16.55 15.02 9 60391 20283 31616661
Lupus-like syndrome 16.46 15.02 22 60378 2473 31634471
Stress ulcer 16.41 15.02 6 60394 71 31636873
Renal tubular necrosis 16.33 15.02 4 60396 14755 31622189
Hypophagia 16.27 15.02 11 60389 22031 31614913
Undifferentiated connective tissue disease 16.25 15.02 5 60395 33 31636911
Sensitivity to weather change 16.16 15.02 17 60383 1484 31635460
Diabetic ketoacidosis 16.14 15.02 6 60394 16899 31620045
Encephalopathy 16.13 15.02 23 60377 32451 31604493
Central nervous system infection 15.91 15.02 11 60389 539 31636405
Sudden death 15.83 15.02 4 60396 14453 31622491
Shock 15.80 15.02 12 60388 22633 31614311
Haemoptysis 15.79 15.02 23 60377 32166 31604778
Tuberculosis 15.70 15.02 43 60357 8298 31628646
Blood potassium increased 15.42 15.02 5 60395 15340 31621604
Hepatic fibrosis 15.40 15.02 27 60373 3847 31633097
Granulomatous dermatitis 15.29 15.02 8 60392 234 31636710
Feeding disorder 15.22 15.02 36 60364 6350 31630594
Dyspnoea exertional 15.19 15.02 32 60368 38805 31598139
Single functional kidney 15.19 15.02 6 60394 89 31636855
Urinary incontinence 15.15 15.02 7 60393 17313 31619631
Myoclonus 15.08 15.02 4 60396 13986 31622958
Aphthous ulcer 15.03 15.02 29 60371 4445 31632499

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 8348.98 13.60 8311 313847 283494 70322792
Drug ineffective 6318.98 13.60 13390 308768 926362 69679924
Drug intolerance 5389.78 13.60 5844 316314 219843 70386443
Joint swelling 4405.61 13.60 5575 316583 247636 70358650
Contraindicated product administered 3727.65 13.60 3777 318381 130835 70475451
Synovitis 3534.23 13.60 3602 318556 125626 70480660
Treatment failure 3048.04 13.60 3508 318650 140634 70465652
Arthropathy 2643.42 13.60 3329 318829 146728 70459558
Therapeutic product effect decreased 2373.90 13.60 3081 319077 139937 70466349
Arthralgia 1717.31 13.60 5597 316561 497793 70108493
Hand deformity 1652.01 13.60 2000 320158 84482 70521804
Swelling 1622.07 13.60 2998 319160 185541 70420745
Pain 1548.22 13.60 6287 315871 622529 69983757
Pemphigus 1423.40 13.60 1819 320339 81217 70525069
Abdominal discomfort 1412.46 13.60 3052 319106 211606 70394680
Death 1373.44 13.60 318 321840 509743 70096543
C-reactive protein abnormal 1373.22 13.60 1245 320913 37334 70568952
Anti-cyclic citrullinated peptide antibody positive 1351.34 13.60 1630 320528 68555 70537731
Systemic lupus erythematosus 1323.67 13.60 1952 320206 99950 70506336
Alopecia 1313.50 13.60 2829 319329 195661 70410625
Musculoskeletal stiffness 1278.12 13.60 2356 319802 145404 70460882
Drug hypersensitivity 1271.45 13.60 3312 318846 259147 70347139
Acute kidney injury 1259.64 13.60 305 321853 474319 70131967
Rheumatoid factor positive 1228.51 13.60 1298 320860 47102 70559184
Peripheral swelling 1212.66 13.60 3050 319108 233513 70372773
Hepatic enzyme increased 1209.64 13.60 2383 319775 154607 70451679
Glossodynia 1202.21 13.60 1711 320447 84776 70521510
Hypersensitivity 1151.80 13.60 2938 319220 226874 70379412
Hypotension 1011.44 13.60 292 321866 404089 70202197
Red blood cell sedimentation rate abnormal 991.42 13.60 770 321388 18533 70587753
Pericarditis 986.95 13.60 1543 320615 83162 70523124
Therapeutic product effect incomplete 978.29 13.60 1865 320293 118017 70488269
Completed suicide 938.35 13.60 19 322139 227116 70379170
Toxicity to various agents 924.81 13.60 293 321865 381879 70224407
Wound 851.46 13.60 1573 320585 97159 70509127
Loss of personal independence in daily activities 839.22 13.60 1436 320722 83474 70522812
Drug interaction 825.70 13.60 350 321808 381091 70225195
Psoriatic arthropathy 786.71 13.60 1203 320955 63568 70542718
Febrile neutropenia 786.16 13.60 33 322125 204285 70402001
Anaemia 769.11 13.60 439 321719 402984 70203302
Red blood cell sedimentation rate increased 759.03 13.60 907 321251 37735 70568551
Helicobacter infection 721.91 13.60 1066 321092 54590 70551696
Rash 714.98 13.60 4355 317803 506207 70100079
Bone erosion 709.92 13.60 573 321585 14600 70591686
Infection 702.66 13.60 2330 319828 208455 70397831
Discomfort 698.87 13.60 1505 320653 103931 70502355
Gastrointestinal disorder 674.99 13.60 1484 320674 103943 70502343
Duodenal ulcer perforation 670.16 13.60 984 321174 50128 70556158
Infusion related reaction 653.39 13.60 2178 319980 195356 70410930
Constipation 645.98 13.60 174 321984 252264 70354022
Sleep disorder due to general medical condition, insomnia type 620.01 13.60 788 321370 34944 70571342
Impaired healing 612.42 13.60 1162 320996 73212 70533074
C-reactive protein increased 605.39 13.60 1463 320695 109054 70497232
Irritable bowel syndrome 592.97 13.60 927 321231 49923 70556363
Muscle injury 585.96 13.60 796 321362 37698 70568588
Folliculitis 573.22 13.60 830 321328 41740 70564546
Mobility decreased 564.67 13.60 1364 320794 101635 70504651
Dehydration 561.58 13.60 165 321993 225977 70380309
Lower respiratory tract infection 544.28 13.60 1416 320742 110497 70495789
Malignant neoplasm progression 529.69 13.60 4 322154 121735 70484551
Osteoarthritis 509.17 13.60 1074 321084 73073 70533213
Overdose 505.96 13.60 82 322076 169663 70436623
Cardiac arrest 504.80 13.60 65 322093 159769 70446517
Hyponatraemia 491.61 13.60 71 322087 160016 70446270
Thrombocytopenia 483.33 13.60 241 321917 238869 70367417
Arthritis 481.82 13.60 1245 320913 96735 70509551
Seizure 481.68 13.60 109 322049 177853 70428433
Rheumatoid nodule 477.52 13.60 456 321702 14611 70591675
Bradycardia 473.02 13.60 22 322136 124593 70481693
Condition aggravated 460.05 13.60 3419 318739 424216 70182070
Ill-defined disorder 455.19 13.60 859 321299 53882 70552404
Sinusitis 442.93 13.60 1729 320429 167466 70438820
Somnolence 425.73 13.60 224 321934 215382 70390904
Neutropenia 423.26 13.60 329 321829 256827 70349459
Stomatitis 421.87 13.60 1414 320744 127097 70479189
Intentional overdose 403.24 13.60 9 322149 98426 70507860
Inflammation 401.66 13.60 1014 321144 77651 70528635
Hyperkalaemia 397.58 13.60 21 322137 106570 70499716
Disability 394.54 13.60 410 321748 14573 70591713
Blister 393.05 13.60 1175 320983 99351 70506935
Disease progression 389.39 13.60 114 322044 156558 70449728
Knee arthroplasty 388.32 13.60 617 321541 33684 70572602
Tremor 387.22 13.60 113 322045 155511 70450775
Maternal exposure during pregnancy 381.98 13.60 1273 320885 114072 70492214
Product use issue 367.26 13.60 1705 320453 178232 70428054
Atrial fibrillation 363.20 13.60 192 321966 184156 70422130
Foot deformity 349.58 13.60 450 321708 20205 70586081
Dyspnoea 345.56 13.60 2069 320089 767991 69838295
Fall 340.12 13.60 968 321190 443128 70163158
Fibromyalgia 328.04 13.60 693 321465 47181 70559105
Dizziness 328.02 13.60 1050 321108 463091 70143195
Tenosynovitis 326.62 13.60 359 321799 13617 70592669
Hypokalaemia 319.55 13.60 99 322059 131089 70475197
Drug tolerance decreased 318.07 13.60 301 321857 9532 70596754
Electrocardiogram QT prolonged 312.89 13.60 16 322142 83501 70522785
Osteoporosis 312.26 13.60 688 321470 48219 70558067
Hip arthroplasty 310.01 13.60 499 321659 27541 70578745
Musculoskeletal disorder 309.98 13.60 417 321741 19554 70586732
Rhabdomyolysis 307.01 13.60 37 322121 95723 70510563
Cardio-respiratory arrest 305.89 13.60 46 322112 100631 70505655
Joint range of motion decreased 305.45 13.60 476 321682 25550 70580736
Respiratory failure 299.57 13.60 199 321959 168536 70437750
Tachycardia 296.61 13.60 176 321982 158370 70447916
Platelet count decreased 291.86 13.60 229 321929 177993 70428293
Depressed level of consciousness 289.83 13.60 30 322128 87401 70518885
Drug eruption 287.33 13.60 586 321572 38910 70567376
Sepsis 281.07 13.60 422 321736 244123 70362163
Cardiac failure congestive 278.90 13.60 133 322025 135324 70470962
Hypoglycaemia 275.74 13.60 48 322110 94316 70511970
Suicide attempt 274.98 13.60 23 322135 79487 70526799
Granuloma skin 269.42 13.60 246 321912 7436 70598850
Plasma cell myeloma 268.09 13.60 16 322142 73185 70533101
Blood parathyroid hormone decreased 266.95 13.60 263 321895 8761 70597525
Cardiac failure 263.38 13.60 163 321995 143378 70462908
Agitation 263.19 13.60 52 322106 93323 70512963
Joint stiffness 260.74 13.60 526 321632 34650 70571636
Blood cholesterol increased 258.00 13.60 761 321397 63843 70542443
Cerebrovascular accident 256.28 13.60 168 321990 143302 70462984
Gastrointestinal haemorrhage 253.55 13.60 155 322003 137253 70469033
Therapeutic response decreased 252.24 13.60 708 321450 57745 70548541
Adverse event 245.58 13.60 631 321527 48830 70557456
Neutrophil count decreased 245.24 13.60 42 322116 83514 70522772
Panniculitis 243.89 13.60 271 321887 10405 70595881
Pneumonia aspiration 243.00 13.60 9 322149 62280 70544006
Nasopharyngitis 238.44 13.60 1777 320381 220429 70385857
Metabolic acidosis 237.64 13.60 29 322129 74317 70531969
Syncope 237.61 13.60 241 321917 165468 70440818
Pyrexia 233.78 13.60 1706 320452 605246 70001040
Hallucination 233.61 13.60 34 322124 76226 70530060
Lactic acidosis 232.81 13.60 16 322142 65008 70541278
International normalised ratio increased 231.66 13.60 43 322115 80683 70525603
Hypoxia 229.89 13.60 69 322089 93275 70513011
Abdominal pain 227.70 13.60 794 321364 341333 70264953
Mental status changes 224.55 13.60 16 322142 63085 70543201
Product dose omission issue 218.65 13.60 409 321749 217059 70389227
Pain in extremity 216.88 13.60 2361 319797 325721 70280565
Rheumatic fever 214.24 13.60 328 321830 17332 70588954
Anxiety 214.01 13.60 423 321735 219907 70386379
Vision blurred 210.16 13.60 84 322074 94900 70511386
Hyperglycaemia 209.74 13.60 24 322134 64648 70541638
Respiratory arrest 206.32 13.60 9 322149 53924 70552362
Decreased appetite 203.65 13.60 706 321452 304074 70302212
Vomiting 203.23 13.60 1721 320437 591390 70014896
Chest pain 201.49 13.60 535 321623 250725 70355561
Adverse drug reaction 201.31 13.60 616 321542 52728 70553558
Unresponsive to stimuli 200.88 13.60 8 322150 51923 70554363
Urinary tract infection 197.74 13.60 532 321626 248237 70358049
Swollen joint count increased 197.44 13.60 276 321882 13424 70592862
Coma 197.11 13.60 85 322073 91759 70514527
Sedation 196.54 13.60 3 322155 46728 70559558
Oedema peripheral 195.80 13.60 469 321689 227622 70378664
Multiple organ dysfunction syndrome 195.23 13.60 126 322032 108389 70497897
Nodule 193.50 13.60 335 321823 19634 70586652
Neoplasm progression 189.81 13.60 3 322155 45225 70561061
Rheumatoid lung 188.55 13.60 143 322015 3316 70602970
Finger deformity 187.42 13.60 182 321976 5954 70600332
Enthesopathy 187.37 13.60 239 321919 10630 70595656
Chest discomfort 182.75 13.60 177 321981 124204 70482082
Blood glucose increased 180.63 13.60 123 322035 102859 70503427
Grip strength decreased 177.30 13.60 282 321876 15403 70590883
Musculoskeletal pain 173.93 13.60 842 321316 89485 70516801
Aggression 173.20 13.60 12 322146 48434 70557852
Pulmonary fibrosis 172.67 13.60 440 321718 33870 70572416
Serotonin syndrome 171.87 13.60 4 322154 42110 70564176
Balance disorder 171.41 13.60 98 322060 90030 70516256
Loss of consciousness 169.96 13.60 278 321880 155438 70450848
Cognitive disorder 169.57 13.60 35 322123 60921 70545365
Pulmonary embolism 168.51 13.60 280 321878 155587 70450699
Impaired work ability 167.40 13.60 281 321877 16059 70590227
Dysarthria 166.82 13.60 39 322119 62274 70544012
Urinary retention 164.18 13.60 22 322136 52498 70553788
Asthenia 162.47 13.60 1315 320843 456351 70149935
Apparent death 161.92 13.60 120 322038 2684 70603602
COVID-19 160.65 13.60 146 322012 105611 70500675
Renal failure 160.47 13.60 391 321767 188679 70417607
Blood pressure decreased 159.57 13.60 110 322048 91405 70514881
Blood creatine phosphokinase increased 158.83 13.60 41 322117 61222 70545064
Cerebral haemorrhage 158.22 13.60 27 322131 53837 70552449
Skin ulcer 158.03 13.60 530 321628 47615 70558671
Respiratory distress 157.03 13.60 29 322129 54621 70551665
Rheumatoid factor negative 156.50 13.60 84 322074 1038 70605248
White blood cell count decreased 156.40 13.60 337 321821 169804 70436482
Orthostatic hypotension 156.33 13.60 24 322134 51719 70554567
Lethargy 156.21 13.60 73 322085 75177 70531109
Septic shock 155.54 13.60 168 321990 112090 70494196
Intentional product misuse 155.04 13.60 84 322074 79511 70526775
Encephalopathy 154.72 13.60 44 322114 61617 70544669
Disorientation 153.59 13.60 37 322121 57886 70548400
Myalgia 153.12 13.60 334 321824 167558 70438728
Ascites 152.28 13.60 58 322100 67489 70538797
Liver function test increased 151.95 13.60 416 321742 33431 70572855
Pancytopenia 151.10 13.60 285 321873 150822 70455464
Pleural effusion 150.86 13.60 231 321927 132633 70473653
Hypomagnesaemia 148.98 13.60 9 322149 40755 70565531
Pulmonary oedema 148.72 13.60 95 322063 82183 70524103
Limb deformity 147.72 13.60 124 322034 3341 70602945
Melaena 143.66 13.60 39 322119 56316 70549970
Dislocation of vertebra 143.44 13.60 142 322016 4758 70601528
Haemorrhage 143.16 13.60 103 322055 83712 70522574
Skin necrosis 142.05 13.60 261 321897 16030 70590256
Dysphagia 141.21 13.60 183 321975 112651 70493635
Restlessness 140.78 13.60 14 322144 42114 70564172
Deformity 140.75 13.60 181 321977 8116 70598170
Chills 139.62 13.60 279 321879 144507 70461779
Haematuria 139.35 13.60 57 322101 63516 70542770
Drug reaction with eosinophilia and systemic symptoms 137.28 13.60 46 322112 57967 70548319
Hyperhidrosis 136.17 13.60 243 321915 131343 70474943
Tuberculin test positive 135.99 13.60 115 322043 3131 70603155
Hypervolaemia 135.87 13.60 12 322146 39694 70566592
Abnormal behaviour 135.43 13.60 5 322153 34704 70571582
Renal impairment 134.86 13.60 282 321876 143655 70462631
Wrong technique in product usage process 134.53 13.60 72 322086 68626 70537660
Sleep disorder 133.54 13.60 650 321508 69222 70537064
Acute myocardial infarction 133.32 13.60 83 322075 72804 70533482
Pneumonia 133.29 13.60 1907 320251 594325 70011961
Oral mucosal exfoliation 133.28 13.60 82 322076 1332 70604954
Blood creatinine increased 132.45 13.60 282 321876 142719 70463567
Haemoglobin decreased 129.78 13.60 486 321672 204673 70401613
Disturbance in attention 129.35 13.60 20 322138 42874 70563412
Intentional self-injury 129.18 13.60 3 322155 31647 70574639
Altered state of consciousness 126.94 13.60 16 322142 40006 70566280
Urticaria 125.96 13.60 1212 320946 161837 70444449
Coronary artery disease 125.45 13.60 64 322094 62672 70543614
Ulcer 125.17 13.60 326 321832 25428 70580858
Alanine aminotransferase abnormal 124.63 13.60 168 321990 7891 70598395
Pancreatitis acute 123.67 13.60 27 322131 45197 70561089
Palmar-plantar erythrodysaesthesia syndrome 122.94 13.60 3 322155 30244 70576042
Generalised tonic-clonic seizure 122.10 13.60 21 322137 41640 70564646
Sciatica 122.02 13.60 314 321844 24313 70581973
Flushing 120.61 13.60 117 322041 82055 70524231
Ventricular tachycardia 119.40 13.60 13 322145 36410 70569876
Joint laxity 119.40 13.60 93 322065 2246 70604040
Ankylosing spondylitis 118.93 13.60 200 321958 11446 70594840
Joint injury 118.90 13.60 329 321829 26603 70579683
Rectal haemorrhage 117.62 13.60 77 322081 65754 70540532
Haematoma 117.02 13.60 37 322121 48381 70557905
Musculoskeletal deformity 115.51 13.60 70 322088 1105 70605181
Hallucination, visual 115.25 13.60 4 322154 29333 70576953
Seronegative arthritis 114.20 13.60 106 322052 3273 70603013
Joint effusion 112.97 13.60 230 321928 15247 70591039
Physical disability 112.83 13.60 98 322060 2769 70603517
Psychotic disorder 112.73 13.60 18 322140 37683 70568603
Joint destruction 112.49 13.60 122 322036 4556 70601730
Chronic kidney disease 112.41 13.60 69 322089 60988 70545298
Joint arthroplasty 109.93 13.60 92 322066 2468 70603818
Lymphocyte count decreased 109.35 13.60 31 322127 43508 70562778
Cerebral infarction 109.18 13.60 30 322128 42979 70563307
Drug withdrawal syndrome 108.99 13.60 11 322147 32704 70573582
Epilepsy 108.43 13.60 22 322136 38762 70567524
Night sweats 108.13 13.60 439 321719 43245 70563041
Acute respiratory failure 105.44 13.60 56 322102 53609 70552677
Red blood cell sedimentation rate 104.26 13.60 120 322038 4790 70601496
Toxic epidermal necrolysis 103.45 13.60 26 322132 39531 70566755
Drug level increased 103.39 13.60 20 322138 36449 70569837
Arrhythmia 102.59 13.60 64 322094 56079 70550207
Asthma 102.29 13.60 250 321908 120543 70485743
Haemoptysis 102.11 13.60 53 322105 51399 70554887
Product use in unapproved indication 101.93 13.60 540 321618 206938 70399348
Fluid retention 101.73 13.60 83 322075 63302 70542984
Urinary incontinence 100.66 13.60 24 322134 37818 70568468
Neuropathy peripheral 100.25 13.60 272 321886 126624 70479662
Haematochezia 99.42 13.60 111 322047 72970 70533316
Dyspnoea exertional 98.33 13.60 127 322031 78303 70527983
Accidental overdose 98.02 13.60 20 322138 35101 70571185
Blood calcium decreased 97.94 13.60 9 322149 28837 70577449
Aphasia 97.71 13.60 37 322121 43212 70563074
Circulatory collapse 97.36 13.60 21 322137 35453 70570833
Subdural haematoma 97.21 13.60 10 322148 29288 70576998
Intentional product use issue 96.70 13.60 901 321257 119241 70487045
Bone swelling 95.94 13.60 69 322089 1471 70604815
Ejection fraction decreased 95.88 13.60 13 322145 30749 70575537
Blood bilirubin increased 95.44 13.60 79 322079 59822 70546464
Ear pain 95.18 13.60 309 321849 27290 70578996
Diverticulitis 95.16 13.60 409 321749 41325 70564961
Cardiac disorder 95.11 13.60 78 322080 59337 70546949
Abdominal distension 94.75 13.60 209 321949 104460 70501826
Dyskinesia 94.71 13.60 34 322124 41040 70565246
Dysgeusia 93.86 13.60 54 322104 49448 70556838
Adverse reaction 93.85 13.60 152 322006 8430 70597856
Type 2 diabetes mellitus 92.94 13.60 422 321736 43658 70562628
Loose body in joint 92.90 13.60 63 322095 1218 70605068
Cardiogenic shock 92.78 13.60 25 322133 36282 70570004
Inappropriate antidiuretic hormone secretion 92.05 13.60 3 322155 23273 70583013
Exostosis 91.75 13.60 202 321956 14143 70592143
Femur fracture 90.94 13.60 365 321793 35767 70570519
Hypocalcaemia 90.83 13.60 45 322113 44814 70561472
Sinus bradycardia 90.16 13.60 4 322154 23619 70582667
Arthrodesis 90.07 13.60 78 322080 2195 70604091
Blood urea increased 90.06 13.60 48 322110 45861 70560425
Breast cancer stage III 89.50 13.60 130 322028 6551 70599735
Surgical failure 88.29 13.60 52 322106 777 70605509
Gastric disorder 88.21 13.60 342 321816 32980 70573306
Presyncope 88.03 13.60 30 322128 37408 70568878
Diabetic ketoacidosis 87.83 13.60 18 322140 31494 70574792
Acute myeloid leukaemia 87.65 13.60 17 322141 30923 70575363
Fine motor skill dysfunction 87.43 13.60 111 322047 4913 70601373
Sinus tachycardia 87.32 13.60 23 322135 33890 70572396
Delirium 87.32 13.60 127 322031 74487 70531799
Foot operation 87.21 13.60 109 322049 4748 70601538
Cholestasis 86.88 13.60 55 322103 47817 70558469
Clostridium difficile colitis 86.34 13.60 14 322144 28982 70577304
Labelled drug-drug interaction medication error 86.17 13.60 6 322152 24121 70582165
Haemorrhage intracranial 86.11 13.60 7 322151 24770 70581516
Poisoning 85.78 13.60 4 322154 22618 70583668
Dysuria 85.35 13.60 51 322107 45743 70560543
Shoulder arthroplasty 85.03 13.60 85 322073 2882 70603404
Transient ischaemic attack 84.46 13.60 52 322106 45892 70560394
Respiratory depression 83.63 13.60 8 322150 24823 70581463
Neutropenic sepsis 83.63 13.60 8 322150 24822 70581464
Tumour lysis syndrome 83.60 13.60 3 322155 21357 70584929
Tendonitis 83.00 13.60 255 321903 21867 70584419
Chronic obstructive pulmonary disease 82.46 13.60 141 322017 77500 70528786
Wrist deformity 82.21 13.60 68 322090 1794 70604492
Product quality issue 82.05 13.60 19 322139 30542 70575744
Hemiparesis 81.68 13.60 21 322137 31448 70574838
Fatigue 81.54 13.60 4547 317611 819772 69786514
Withdrawal syndrome 81.35 13.60 9 322149 24895 70581391
Basal cell carcinoma 81.31 13.60 336 321822 33362 70572924
Deep vein thrombosis 80.41 13.60 248 321910 110794 70495492
Oxygen saturation decreased 80.15 13.60 266 321892 116163 70490123
Myoclonus 80.12 13.60 12 322146 26343 70579943
Contusion 80.07 13.60 912 321246 127124 70479162
Premature delivery 80.03 13.60 4 322154 21300 70584986
Full blood count decreased 79.78 13.60 8 322150 23910 70582376
Status epilepticus 79.77 13.60 9 322149 24517 70581769
Atlantoaxial instability 79.42 13.60 35 322123 270 70606016
Limb discomfort 78.73 13.60 305 321853 29400 70576886
Ileus 78.56 13.60 9 322149 24228 70582058
Intestinal obstruction 78.53 13.60 39 322119 38786 70567500
Upper gastrointestinal haemorrhage 78.32 13.60 36 322122 37441 70568845
Mineral metabolism disorder 77.91 13.60 35 322123 284 70606002
Angioedema 77.33 13.60 114 322044 66496 70539790
Dry skin 77.12 13.60 84 322074 55847 70550439
Pulmonary hypertension 77.12 13.60 59 322099 46477 70559809
Tongue disorder 76.52 13.60 179 321979 13048 70593238
Eosinophilia 76.42 13.60 44 322114 40275 70566011
Suicidal ideation 76.13 13.60 124 322034 69472 70536814
Depressed mood 75.94 13.60 53 322105 43767 70562519
Pallor 75.84 13.60 46 322112 40928 70565358
Pericardial effusion 75.80 13.60 48 322110 41728 70564558
Intervertebral disc space narrowing 75.54 13.60 60 322098 1492 70604794
Irritability 74.93 13.60 40 322118 38185 70568101
Haematemesis 74.52 13.60 67 322091 48730 70557556
Sensitivity to weather change 74.06 13.60 126 322032 7279 70599007
Myocardial infarction 73.96 13.60 466 321692 171179 70435107
Hospitalisation 73.80 13.60 166 321992 82402 70523884
Agranulocytosis 73.54 13.60 46 322112 40252 70566034
Full blood count abnormal 73.23 13.60 31 322127 33847 70572439
Small intestinal obstruction 73.20 13.60 12 322146 24643 70581643
Muscle spasticity 72.98 13.60 226 321932 19463 70586823
Blood potassium decreased 72.60 13.60 52 322106 42369 70563917
Shock 72.59 13.60 47 322111 40378 70565908
Ventricular fibrillation 72.49 13.60 17 322141 27094 70579192
Renal tubular necrosis 71.72 13.60 10 322148 23161 70583125
Hyperbilirubinaemia 71.62 13.60 9 322149 22559 70583727
Spinal instability 71.54 13.60 35 322123 351 70605935
Bacteraemia 71.54 13.60 22 322136 29287 70576999
Mucosal inflammation 71.34 13.60 124 322034 67726 70538560
Ankle deformity 71.29 13.60 42 322116 628 70605658
Hypothermia 71.07 13.60 6 322152 20588 70585698
Bone cyst 70.95 13.60 76 322082 2798 70603488
Product administration error 70.56 13.60 23 322135 29500 70576786
Bone pain 70.44 13.60 76 322082 50746 70555540
Dystonia 70.09 13.60 5 322153 19701 70586585
Deafness transitory 69.65 13.60 47 322111 901 70605385
Intestinal sepsis 69.52 13.60 44 322114 753 70605533
Thyroid neoplasm 69.46 13.60 76 322082 2867 70603419
Bone marrow failure 69.37 13.60 72 322086 48938 70557348
Torsade de pointes 69.36 13.60 3 322155 18113 70588173
Drug use disorder 69.07 13.60 129 322029 8022 70598264
Terminal state 68.94 13.60 95 322063 4557 70601729
Leukocytosis 68.71 13.60 48 322110 39620 70566666
Bone density abnormal 68.57 13.60 75 322083 2828 70603458
Dementia 68.41 13.60 10 322148 22355 70583931
Pancreatitis 68.22 13.60 112 322046 62556 70543730
Head injury 67.99 13.60 35 322123 34106 70572180
Retinitis 67.83 13.60 89 322069 4071 70602215
Flatulence 67.74 13.60 45 322113 38136 70568150
Product prescribing error 67.65 13.60 47 322111 38905 70567381
Blood sodium decreased 67.59 13.60 28 322130 30970 70575316
Hepatic encephalopathy 67.40 13.60 10 322148 22108 70584178
Mitral valve incompetence 67.18 13.60 19 322139 26709 70579577
Cough 66.87 13.60 1057 321101 324320 70281966
Metastases to bone 66.19 13.60 11 322147 22365 70583921
Disseminated intravascular coagulation 66.09 13.60 35 322123 33563 70572723
Therapy non-responder 66.03 13.60 585 321573 76330 70529956
Blood iron abnormal 65.97 13.60 50 322108 1158 70605128
Lupus-like syndrome 65.71 13.60 155 322003 11360 70594926
Gastrooesophageal reflux disease 65.68 13.60 203 321955 90636 70515650
International normalised ratio fluctuation 65.55 13.60 77 322081 3142 70603144
X-ray abnormal 65.50 13.60 69 322089 2491 70603795
Creatinine renal clearance decreased 65.35 13.60 3 322155 17197 70589089
Polyomavirus-associated nephropathy 65.32 13.60 98 322060 5085 70601201
Mania 65.24 13.60 3 322155 17171 70589115
Synovial cyst 65.09 13.60 131 322027 8611 70597675
Confusional state 64.96 13.60 905 321253 283493 70322793
Anuria 64.46 13.60 7 322151 19646 70586640
Weight increased 64.31 13.60 1497 320661 240834 70365452
Anti-cyclic citrullinated peptide antibody 64.05 13.60 78 322080 3307 70602979
Brain oedema 63.99 13.60 14 322144 23404 70582882
Metastases to liver 63.93 13.60 19 322139 25859 70580427
Exposure during pregnancy 63.76 13.60 644 321514 87073 70519213
Therapy cessation 63.47 13.60 37 322121 33639 70572647
Obstructive airways disorder 63.02 13.60 20 322138 26093 70580193
Bone disorder 62.29 13.60 198 321960 17292 70588994
Infusion site reaction 62.17 13.60 70 322088 2727 70603559
Hallucination, auditory 61.48 13.60 6 322152 18322 70587964
Stevens-Johnson syndrome 61.47 13.60 44 322114 35863 70570423
Aspiration 61.41 13.60 5 322153 17670 70588616
Multiple fractures 61.03 13.60 110 322048 6655 70599631
Neck deformity 60.98 13.60 56 322102 1705 70604581
Sudden death 60.89 13.60 11 322147 21053 70585233
Retinal toxicity 60.87 13.60 50 322108 1306 70604980
Systemic lupus erythematosus rash 60.79 13.60 54 322104 1573 70604713
Abdominal pain lower 60.70 13.60 26 322132 28190 70578096
Joint dislocation 60.69 13.60 174 321984 14357 70591929
Tachypnoea 60.64 13.60 27 322131 28611 70577675
Incorrect dose administered 60.56 13.60 133 322025 66586 70539700
Coordination abnormal 60.41 13.60 3 322155 16063 70590223
Device dislocation 60.41 13.60 14 322144 22493 70583793
Spinal column injury 60.30 13.60 59 322099 1948 70604338
Muscle rigidity 60.27 13.60 7 322151 18643 70587643
Myopathy 60.11 13.60 7 322151 18605 70587681
Gastrointestinal pain 59.89 13.60 123 322035 8204 70598082
Bloody discharge 59.80 13.60 55 322103 1678 70604608
Colitis 59.76 13.60 125 322033 63689 70542597
White blood cell count increased 59.66 13.60 143 322015 69430 70536856
Body temperature increased 59.30 13.60 346 321812 39488 70566798
Haemodynamic instability 58.63 13.60 3 322155 15655 70590631
Electrolyte imbalance 57.39 13.60 25 322133 26836 70579450
Dactylitis 56.80 13.60 60 322098 2173 70604113
Acidosis 56.25 13.60 8 322150 18255 70588031
Hepatic enzyme abnormal 56.19 13.60 102 322056 6205 70600081
Pollakiuria 55.98 13.60 42 322116 33419 70572867
Cholelithiasis 55.95 13.60 80 322078 47260 70559026
Atrial flutter 55.85 13.60 12 322146 20315 70585971
Injection site reaction 55.81 13.60 403 321755 49449 70556837
Hepatic failure 55.55 13.60 111 322047 57514 70548772
Extrapyramidal disorder 55.50 13.60 13 322145 20737 70585549
Device issue 55.20 13.60 20 322138 24005 70582281
Toxic skin eruption 55.20 13.60 12 322146 20150 70586136
Visual acuity reduced 55.08 13.60 29 322129 27901 70578385
Gastritis 55.07 13.60 73 322085 44518 70561768
Ovarian neoplasm 55.01 13.60 34 322124 557 70605729
Mydriasis 54.94 13.60 5 322153 16148 70590138
Rash erythematous 54.84 13.60 94 322064 51624 70554662
Spinal stenosis 54.13 13.60 168 321990 14485 70591801
Diarrhoea 54.07 13.60 2959 319199 780382 69825904
Osteosclerosis 53.92 13.60 75 322083 3630 70602656
Cyanosis 53.86 13.60 19 322139 23187 70583099
Speech disorder 53.57 13.60 92 322066 50488 70555798
Delusion 53.30 13.60 11 322147 19154 70587132
Angina pectoris 53.10 13.60 86 322072 48297 70557989
Hypophosphataemia 53.07 13.60 6 322152 16320 70589966
Face oedema 53 13.60 25 322133 25614 70580672
Drug ineffective for unapproved indication 53.00 13.60 58 322100 38480 70567806
Acute coronary syndrome 52.88 13.60 13 322145 20066 70586220
Pulmonary arterial hypertension 52.74 13.60 43 322115 32812 70573474
Aplastic anaemia 52.25 13.60 7 322151 16709 70589577
Heart rate increased 52.24 13.60 276 321882 105872 70500414
Fear 51.92 13.60 15 322143 20796 70585490
Peritonitis 51.82 13.60 27 322131 26132 70580154
Cellulitis 51.65 13.60 252 321906 98676 70507610
Lower gastrointestinal haemorrhage 51.60 13.60 4 322154 14716 70591570
Investigation abnormal 51.49 13.60 52 322106 1785 70604501
Supraventricular tachycardia 51.45 13.60 13 322145 19697 70586589
Electrocardiogram abnormal 51.36 13.60 4 322154 14660 70591626
Fear of injection 50.90 13.60 101 322057 6571 70599715
Mouth ulceration 50.90 13.60 298 321860 34051 70572235
Cardiac failure acute 50.84 13.60 9 322149 17478 70588808
Atrioventricular block complete 50.76 13.60 5 322153 15158 70591128
Nausea 50.75 13.60 3264 318894 848824 69757462
Left ventricular dysfunction 50.58 13.60 10 322148 17947 70588339
Ataxia 50.58 13.60 21 322137 23196 70583090
Haemodialysis 50.35 13.60 9 322149 17357 70588929
Extremity contracture 50.25 13.60 49 322109 1611 70604675
Lower limb fracture 50.12 13.60 179 321979 16593 70589693
Polyarthritis 50.07 13.60 134 322024 10622 70595664
Therapy interrupted 50.03 13.60 25 322133 24777 70581509
Emotional distress 50.01 13.60 57 322101 37131 70569155
Ischaemic stroke 49.89 13.60 40 322118 30780 70575506
Tubulointerstitial nephritis 49.81 13.60 46 322112 33030 70573256
Renal injury 49.69 13.60 7 322151 16087 70590199
Hypophagia 49.38 13.60 70 322088 41500 70564786
Acute generalised exanthematous pustulosis 49.21 13.60 6 322152 15391 70590895
Cardiomegaly 49.12 13.60 25 322133 24520 70581766
Diplopia 48.83 13.60 34 322124 28113 70578173
Product substitution issue 48.73 13.60 12 322146 18501 70587785
Localised infection 48.70 13.60 287 321871 32871 70573415
Pemphigoid 48.62 13.60 4 322154 14018 70592268
Prostate cancer 48.53 13.60 42 322116 31121 70575165
Muscle twitching 48.18 13.60 15 322143 19812 70586474
Transfusion 48.07 13.60 13 322145 18823 70587463
Tinnitus 48.05 13.60 56 322102 36120 70570166
Myelodysplastic syndrome 47.79 13.60 39 322119 29746 70576540
Metastases to central nervous system 47.70 13.60 6 322152 15028 70591258
Chondropathy 47.62 13.60 57 322101 2373 70603913
Skin exfoliation 47.45 13.60 93 322065 48533 70557753
Vasculitic rash 47.26 13.60 52 322106 1974 70604312
Incontinence 47.23 13.60 3 322155 13025 70593261
Accidental exposure to product 47.20 13.60 35 322123 28016 70578270
Haemorrhoids 46.98 13.60 29 322129 25559 70580727
Metastases to lung 46.81 13.60 9 322149 16475 70589811
Urine output decreased 46.66 13.60 10 322148 16960 70589326
Bursitis 46.62 13.60 242 321916 26431 70579855
Pulmonary thrombosis 46.61 13.60 134 322024 11074 70595212
Malnutrition 46.53 13.60 17 322141 20300 70585986
Palpitations 46.50 13.60 303 321855 110450 70495836
Immune thrombocytopenia 46.17 13.60 9 322149 16315 70589971
Mycotic allergy 46.02 13.60 39 322119 1065 70605221
Pulmonary toxicity 45.78 13.60 130 322028 10668 70595618
Nail disorder 45.67 13.60 127 322031 10297 70595989
Acute respiratory distress syndrome 45.58 13.60 73 322085 41181 70565105
Osteoporotic fracture 45.50 13.60 70 322088 3714 70602572
Bronchitis chronic 45.30 13.60 73 322085 4031 70602255
Weight decreased 45.27 13.60 1069 321089 309419 70296867
Anticipatory anxiety 45.22 13.60 37 322121 961 70605325
Panic attack 45.06 13.60 22 322136 22097 70584189
Fracture delayed union 44.86 13.60 51 322107 2008 70604278
Gait inability 44.80 13.60 367 321791 46808 70559478
Maternal exposure timing unspecified 44.29 13.60 75 322083 4316 70601970
Myocarditis 44.28 13.60 15 322143 18778 70587508
Wrist surgery 44.15 13.60 33 322125 748 70605538
Mental disorder 44.05 13.60 38 322120 28202 70578084
Hyperthyroidism 44.04 13.60 18 322140 20073 70586213
Injection site hypersensitivity 43.99 13.60 47 322111 1725 70604561
Onychomycosis 43.93 13.60 97 322061 6804 70599482
Ventricular extrasystoles 43.91 13.60 14 322144 18212 70588074
Hypoalbuminaemia 43.79 13.60 16 322142 19106 70587180
Nocturia 43.69 13.60 3 322155 12201 70594085
Device related infection 43.64 13.60 49 322109 32136 70574150
Blood glucose decreased 43.50 13.60 28 322130 24131 70582155
Drug tolerance 43.49 13.60 101 322057 7327 70598959
Shock haemorrhagic 43.46 13.60 14 322144 18092 70588194
Sarcoidosis 43.15 13.60 94 322064 6533 70599753
Mycobacterium tuberculosis complex test positive 42.92 13.60 53 322105 2280 70604006
Lip swelling 42.82 13.60 55 322103 33999 70572287
Depression 42.66 13.60 641 321517 198333 70407953
Hair follicle tumour benign 42.65 13.60 26 322132 415 70605871
Oesophagitis 42.53 13.60 25 322133 22627 70583659
Vertigo 42.49 13.60 144 322014 62499 70543787
Tuberculosis 42.28 13.60 156 322002 14692 70591594
Granuloma 42.20 13.60 102 322056 7593 70598693
Cutaneous vasculitis 41.92 13.60 98 322060 7140 70599146
Appendicitis 41.86 13.60 12 322146 16721 70589565
Red cell distribution width decreased 41.85 13.60 44 322114 1585 70604701
Arteriosclerosis coronary artery 41.74 13.60 11 322147 16204 70590082
Pruritus allergic 41.68 13.60 37 322121 1077 70605209
Erectile dysfunction 41.63 13.60 6 322152 13556 70592730
Troponin increased 41.40 13.60 12 322146 16602 70589684
Jaundice 41.39 13.60 105 322053 50003 70556283
Oliguria 41.12 13.60 9 322149 15042 70591244
Myocardial ischaemia 40.97 13.60 30 322128 24170 70582116
Clostridium difficile infection 40.74 13.60 71 322087 38745 70567541
Angina unstable 40.50 13.60 11 322147 15882 70590404
Herpes zoster 40.45 13.60 577 321581 84658 70521628
Secretion discharge 40.34 13.60 140 322018 12793 70593493
Blood magnesium decreased 40.29 13.60 9 322149 14832 70591454
Hepatocellular injury 40.10 13.60 94 322064 45997 70560289
Lyme disease 39.85 13.60 57 322101 2832 70603454
Colitis ischaemic 39.55 13.60 8 322150 14129 70592157
Hypotonia 39.49 13.60 4 322154 11861 70594425
Coagulopathy 39.48 13.60 56 322102 33193 70573093
Skin discolouration 39.43 13.60 68 322090 37257 70569029
Rash maculo-papular 39.41 13.60 109 322049 50436 70555850
Transaminases abnormal 39.37 13.60 31 322127 761 70605525
Joint space narrowing 39.27 13.60 24 322134 385 70605901
Mean platelet volume decreased 39.10 13.60 50 322108 2229 70604057
Vascular access complication 39.02 13.60 44 322114 1717 70604569
Subarachnoid haemorrhage 38.83 13.60 20 322138 19484 70586802
Blood loss anaemia 38.72 13.60 9 322149 14432 70591854
Allergic oedema 38.50 13.60 30 322128 725 70605561
Colitis ulcerative 38.46 13.60 59 322099 33864 70572422
Bronchopulmonary aspergillosis 38.28 13.60 24 322134 20978 70585308
Emotional disorder 38.03 13.60 7 322151 13219 70593067
Prothrombin time prolonged 38.01 13.60 13 322145 16177 70590109
Device difficult to use 37.88 13.60 3 322155 10846 70595440
Incorrect product administration duration 37.78 13.60 3 322155 10821 70595465
Liver injury 37.77 13.60 317 321841 40718 70565568
Pulmonary haemorrhage 37.71 13.60 8 322150 13665 70592621
Cytology abnormal 37.69 13.60 22 322136 323 70605963
Ankle arthroplasty 37.67 13.60 36 322122 1154 70605132
Demyelination 37.65 13.60 94 322064 7142 70599144
Infiltration anaesthesia 37.42 13.60 17 322141 142 70606144
Faeces discoloured 37.25 13.60 40 322118 26769 70579517
Atelectasis 37.22 13.60 46 322112 28916 70577370
Neutrophil count increased 37.21 13.60 40 322118 26755 70579531
Foot fracture 37.19 13.60 182 321976 19418 70586868
Paraesthesia 36.91 13.60 453 321705 145084 70461202
Nightmare 36.82 13.60 28 322130 22128 70584158
Facet joint syndrome 36.76 13.60 84 322074 6029 70600257
Pulmonary mass 36.74 13.60 223 321935 25810 70580476
C-reactive protein 36.33 13.60 46 322112 2030 70604256
Pustular psoriasis 36.21 13.60 71 322087 4579 70601707
Eosinophil count increased 36.13 13.60 12 322146 15210 70591076
Adjustment disorder with depressed mood 35.99 13.60 67 322091 4156 70602130
Atrioventricular block 35.88 13.60 7 322151 12681 70593605
Tricuspid valve incompetence 35.87 13.60 18 322140 17799 70588487
Ear infection 35.81 13.60 236 321922 28100 70578186
Inappropriate schedule of product administration 35.78 13.60 314 321844 107241 70499045
Lymphopenia 35.64 13.60 43 322115 27316 70578970
Drug level decreased 35.62 13.60 7 322151 12617 70593669
Skin papilloma 35.56 13.60 77 322081 5329 70600957
Labile blood pressure 35.36 13.60 46 322112 2086 70604200
Muscular weakness 35.30 13.60 430 321728 137906 70468380
Eye pain 35.23 13.60 63 322095 34039 70572247
Failure to thrive 35.15 13.60 4 322154 10825 70595461
Hypercalcaemia 35.11 13.60 272 321886 34113 70572173
Sleep apnoea syndrome 35.10 13.60 59 322099 32654 70573632
Chromaturia 35.10 13.60 33 322125 23495 70582791
Apnoea 35.07 13.60 4 322154 10805 70595481
Hepatic cytolysis 34.89 13.60 22 322136 19170 70587116
Wound infection 34.80 13.60 165 321993 17377 70588909
Vaginal haemorrhage 34.75 13.60 25 322133 20327 70585959
Acute pulmonary oedema 34.71 13.60 9 322149 13403 70592883
Cholecystitis 34.61 13.60 26 322132 20675 70585611
Lacrimation increased 34.57 13.60 24 322134 19875 70586411
Dialysis 34.41 13.60 18 322140 17384 70588902
Klebsiella infection 34.39 13.60 11 322147 14281 70592005
Underdose 34.38 13.60 50 322108 29333 70576953
Pneumonia fungal 34.07 13.60 3 322155 9950 70596336
Bradyphrenia 34.04 13.60 3 322155 9943 70596343
Mental impairment 33.90 13.60 18 322140 17237 70589049
Epstein-Barr virus infection 33.88 13.60 9 322149 13189 70593097
Coronary artery stenosis 33.83 13.60 6 322152 11638 70594648
Cardiomyopathy 33.78 13.60 42 322116 26331 70579955
Myelosuppression 33.63 13.60 53 322105 30092 70576194
Impaired gastric emptying 33.56 13.60 107 322051 9359 70596927
Neck pain 33.55 13.60 456 321702 66201 70540085
Hypermobility syndrome 33.52 13.60 24 322134 508 70605778
Infusion site pain 33.51 13.60 6 322152 11558 70594728
Hepatotoxicity 33.44 13.60 326 321832 43660 70562626
Activated partial thromboplastin time prolonged 33.21 13.60 10 322148 13495 70592791
Cytomegalovirus infection 33.08 13.60 83 322075 39675 70566611
Respiratory acidosis 32.87 13.60 4 322154 10277 70596009
Salivary hypersecretion 32.83 13.60 9 322149 12916 70593370
Mass excision 32.82 13.60 20 322138 319 70605967
Sensory disturbance 32.66 13.60 11 322147 13821 70592465
Hepatocellular carcinoma 32.57 13.60 4 322154 10204 70596082
Multiple allergies 32.48 13.60 93 322065 7667 70598619
Diabetes mellitus inadequate control 32.35 13.60 33 322125 22612 70583674
Paraesthesia oral 31.92 13.60 15 322143 15402 70590884
Diastolic dysfunction 31.87 13.60 3 322155 9430 70596856
Aspergillus infection 31.77 13.60 21 322137 17847 70588439
Mean cell volume decreased 31.75 13.60 65 322093 4325 70601961
Rash pruritic 31.74 13.60 431 321727 62560 70543726
Joint lock 31.70 13.60 52 322106 2915 70603371
Osteopenia 31.65 13.60 155 322003 16542 70589744
Pulse absent 31.44 13.60 3 322155 9327 70596959
Joint ankylosis 31.07 13.60 37 322121 1532 70604754
Polyuria 31.07 13.60 11 322147 13395 70592891
Hypercholesterolaemia 30.71 13.60 163 321995 17954 70588332
Diffuse large B-cell lymphoma 30.68 13.60 11 322147 13291 70592995
Multiple sclerosis 30.61 13.60 42 322116 25243 70581043
Bronchospasm 30.57 13.60 35 322123 22757 70583529
Enterococcal infection 30.48 13.60 14 322144 14568 70591718
Hyperthermia 30.46 13.60 19 322139 16652 70589634
Hepatic cancer 30.39 13.60 4 322154 9679 70596607
Burning sensation 30.38 13.60 130 322028 52740 70553546
Hiccups 30.26 13.60 3 322155 9049 70597237
Heparin-induced thrombocytopenia 30.20 13.60 3 322155 9034 70597252
Complication associated with device 29.98 13.60 17 322141 15696 70590590
Carpal tunnel syndrome 29.97 13.60 155 322003 16902 70589384
Anal incontinence 29.84 13.60 19 322139 16471 70589815
Brain injury 29.72 13.60 6 322152 10611 70595675
Bundle branch block right 29.69 13.60 6 322152 10604 70595682
Hemiplegia 29.58 13.60 13 322145 13882 70592404
Embolism 29.52 13.60 11 322147 12977 70593309
Purpura 29.51 13.60 23 322135 17952 70588334
Tooth disorder 29.43 13.60 198 321960 23740 70582546
Colitis microscopic 29.42 13.60 99 322059 8906 70597380
Soft tissue disorder 29.34 13.60 54 322104 3320 70602966
Escherichia infection 29.30 13.60 19 322139 16312 70589974
Memory impairment 29.27 13.60 274 321884 92367 70513919
Central nervous system lesion 29.24 13.60 10 322148 12443 70593843
Tardive dyskinesia 29.10 13.60 5 322153 9924 70596362
Posterior reversible encephalopathy syndrome 29.07 13.60 41 322117 24361 70581925
Ileus paralytic 29.04 13.60 3 322155 8758 70597528
Apathy 28.95 13.60 9 322149 11899 70594387
Dysphonia 28.90 13.60 123 322035 49977 70556309
Throat tightness 28.87 13.60 43 322115 24979 70581307
Bundle branch block left 28.86 13.60 6 322152 10393 70595893
Spinal fusion surgery 28.70 13.60 59 322099 3938 70602348
Asphyxia 28.63 13.60 6 322152 10336 70595950
Epistaxis 28.51 13.60 313 321845 102314 70503972
Latent tuberculosis 28.47 13.60 51 322107 3070 70603216
Hyperammonaemia 28.44 13.60 6 322152 10287 70595999
Bladder cancer 28.39 13.60 22 322136 17220 70589066
Osteomyelitis 28.32 13.60 235 321923 30083 70576203
Arthritis bacterial 28.22 13.60 92 322066 8141 70598145
Enterocolitis 28.17 13.60 12 322146 13054 70593232
Deep vein thrombosis postoperative 28.00 13.60 55 322103 3552 70602734
Feeling abnormal 27.96 13.60 466 321692 141853 70464433
Pneumonia viral 27.84 13.60 92 322066 8200 70598086
Bedridden 27.83 13.60 112 322046 10986 70595300
Abnormal dreams 27.66 13.60 7 322151 10596 70595690
Bunion operation 27.53 13.60 26 322132 821 70605465
Rash macular 27.47 13.60 46 322112 25498 70580788
Enteritis 27.32 13.60 12 322146 12819 70593467
Proteinuria 27.11 13.60 58 322100 29316 70576970
Cerebral ischaemia 26.92 13.60 7 322151 10405 70595881
Respiratory disorder 26.88 13.60 284 321874 38839 70567447
Eye swelling 26.84 13.60 41 322117 23573 70582713
Neck mass 26.83 13.60 59 322099 4127 70602159
Frequent bowel movements 26.76 13.60 34 322124 21119 70585167
Blindness 26.71 13.60 40 322118 23187 70583099
Hospice care 26.71 13.60 3 322155 8202 70598084
Hepatitis cholestatic 26.67 13.60 12 322146 12638 70593648
Hypersomnia 26.66 13.60 33 322125 20731 70585555
Hyperlipidaemia 26.58 13.60 42 322116 23821 70582465
Soft tissue swelling 26.54 13.60 30 322128 1174 70605112
Drug level below therapeutic 26.45 13.60 4 322154 8719 70597567
Disease susceptibility 26.41 13.60 17 322141 300 70605986
Glycosylated haemoglobin increased 26.40 13.60 24 322134 17367 70588919
Productive cough 26.36 13.60 228 321930 78109 70528177
Lip dry 26.36 13.60 101 322057 9684 70596602
Thirst 26.34 13.60 17 322141 14632 70591654
Eructation 26.33 13.60 6 322152 9754 70596532
Psychomotor hyperactivity 26.30 13.60 19 322139 15414 70590872
Gait disturbance 26.23 13.60 1059 321099 184047 70422239
Cystitis haemorrhagic 25.92 13.60 4 322154 8589 70597697
Haematocrit decreased 25.92 13.60 153 322005 57105 70549181
Breast cancer metastatic 25.89 13.60 7 322151 10139 70596147
Middle lobe syndrome 25.88 13.60 9 322149 33 70606253
Premature labour 25.86 13.60 3 322155 7997 70598289
Pulseless electrical activity 25.65 13.60 14 322144 13201 70593085
Retching 25.54 13.60 21 322137 15958 70590328
Immobile 25.43 13.60 76 322082 6418 70599868
Hyperuricaemia 25.41 13.60 9 322149 10957 70595329
Abscess 25.31 13.60 34 322124 20620 70585666
Benign prostatic hyperplasia 25.20 13.60 8 322150 10435 70595851
Petechiae 25.12 13.60 30 322128 19142 70587144
Personality change 24.86 13.60 5 322153 8865 70597421
Pseudomonas infection 24.59 13.60 30 322128 18964 70587322
Device leakage 24.56 13.60 6 322152 9302 70596984
Cardiac failure chronic 24.54 13.60 8 322150 10261 70596025
Exercise tolerance decreased 24.52 13.60 4 322154 8244 70598042
Hepatomegaly 24.41 13.60 26 322132 17466 70588820
Bacterial sepsis 24.39 13.60 3 322155 7644 70598642
Cholangitis 24.28 13.60 11 322147 11538 70594748
Hepatitis C 24.23 13.60 14 322144 12793 70593493
Brain natriuretic peptide increased 24.20 13.60 4 322154 8167 70598119
Tendon disorder 24.10 13.60 75 322083 6476 70599810
Peritonitis bacterial 24.08 13.60 6 322152 9178 70597108
Live birth 24.07 13.60 125 322033 13654 70592632
Osteonecrosis of jaw 24.06 13.60 100 322058 40902 70565384
Renal disorder 24.02 13.60 90 322068 37919 70568367
Swelling face 23.95 13.60 178 321980 62986 70543300
Abdominal pain upper 23.71 13.60 1091 321067 192511 70413775
Hypertriglyceridaemia 23.68 13.60 12 322146 11799 70594487
Vascular device infection 23.63 13.60 4 322154 8026 70598260
Glomerular filtration rate decreased 23.62 13.60 36 322122 20720 70585566
Acute hepatic failure 23.62 13.60 57 322101 27615 70578671
Hypothyroidism 23.62 13.60 117 322041 45638 70560648
Laryngitis 23.35 13.60 123 322035 13508 70592778
Gout 23.32 13.60 43 322115 22963 70583323
Myositis 23.30 13.60 27 322131 17462 70588824
Prostatic specific antigen increased 23.29 13.60 7 322151 9459 70596827
Hypovolaemic shock 23.29 13.60 10 322148 10827 70595459
COVID-19 pneumonia 23.22 13.60 40 322118 21929 70584357
Nephropathy toxic 23.17 13.60 30 322128 18484 70587802
Abortion spontaneous 23.04 13.60 54 322104 26425 70579861
Smear cervix abnormal 22.95 13.60 40 322118 2356 70603930
Nystagmus 22.87 13.60 7 322151 9348 70596938
Haemolysis 22.77 13.60 12 322146 11539 70594747
Oedema 22.76 13.60 332 321826 103249 70503037
Blood albumin decreased 22.75 13.60 41 322117 22086 70584200
Hypercapnia 22.71 13.60 5 322153 8324 70597962
Unevaluable event 22.58 13.60 141 322017 51922 70554364
Pyelonephritis 22.52 13.60 30 322128 18259 70588027
Azotaemia 22.52 13.60 4 322154 7749 70598537
Increased appetite 22.48 13.60 10 322148 10603 70595683
Overwork 22.46 13.60 9 322149 53 70606233
Carotid artery stenosis 22.35 13.60 5 322153 8231 70598055
Haemolytic anaemia 22.30 13.60 26 322132 16768 70589518
Spinal disorder 22.29 13.60 92 322066 9128 70597158
Peripheral venous disease 22.29 13.60 102 322056 10585 70595701
Thrombotic microangiopathy 22.26 13.60 29 322129 17819 70588467
Congestive cardiomyopathy 22.06 13.60 11 322147 10915 70595371
Diabetic eye disease 22.03 13.60 12 322146 153 70606133
Lipase increased 22.03 13.60 22 322136 15224 70591062
Walking aid user 22.01 13.60 83 322075 7898 70598388
Blood potassium increased 22.00 13.60 58 322100 27268 70579018
Muscle spasms 21.97 13.60 532 321626 153514 70452772
Tender joint count increased 21.96 13.60 12 322146 154 70606132
Staphylococcal infection 21.96 13.60 147 322011 53257 70553029
Peripheral sensory neuropathy 21.85 13.60 14 322144 12096 70594190
Oropharyngeal pain 21.76 13.60 307 321851 96003 70510283
Cerebral atrophy 21.69 13.60 4 322154 7543 70598743
Neck surgery 21.68 13.60 32 322126 1636 70604650
Nail psoriasis 21.63 13.60 18 322140 479 70605807
Musculoskeletal discomfort 21.62 13.60 147 322011 17685 70588601
Respiratory tract infection 21.55 13.60 109 322049 42289 70563997
Coronary artery occlusion 21.54 13.60 20 322138 14325 70591961
Skin reaction 21.54 13.60 123 322035 13926 70592360
Caesarean section 21.52 13.60 13 322145 11594 70594692
Large intestine perforation 21.52 13.60 17 322141 13178 70593108
Erythema 21.39 13.60 717 321441 198846 70407440
Neurological symptom 21.39 13.60 4 322154 7469 70598817
Therapeutic response unexpected 21.35 13.60 31 322127 18200 70588086
Refusal of treatment by patient 21.32 13.60 6 322152 8464 70597822
Rash papular 21.29 13.60 31 322127 18179 70588107
Eyelid oedema 21.26 13.60 16 322142 12711 70593575
Viral upper respiratory tract infection 21.26 13.60 86 322072 8456 70597830
Muscle relaxant therapy 21.24 13.60 12 322146 165 70606121
Progressive multifocal leukoencephalopathy 21.23 13.60 34 322124 19180 70587106
Nervous system disorder 21.20 13.60 49 322109 24097 70582189
Blood culture positive 21.13 13.60 5 322153 7921 70598365
Gastric haemorrhage 21.04 13.60 20 322138 14165 70592121
Cerebral haematoma 21.01 13.60 4 322154 7374 70598912
Urticarial vasculitis 21.01 13.60 19 322139 567 70605719
Mean cell haemoglobin decreased 20.96 13.60 62 322096 5206 70601080
Cold sweat 20.86 13.60 28 322130 16988 70589298
Spinal meningioma benign 20.82 13.60 10 322148 96 70606190
Swollen tongue 20.73 13.60 92 322066 36954 70569332
Loss of employment 20.72 13.60 37 322121 2222 70604064
Muscle tightness 20.68 13.60 14 322144 11748 70594538
Blood pressure systolic decreased 20.66 13.60 9 322149 9662 70596624
Extra dose administered 20.61 13.60 4 322154 7273 70599013
Erythema multiforme 20.57 13.60 27 322131 16537 70589749
Pleural thickening 20.56 13.60 42 322116 2790 70603496
Duodenal ulcer haemorrhage 20.56 13.60 3 322155 6715 70599571
Knee deformity 20.53 13.60 24 322134 974 70605312
Left ventricular failure 20.51 13.60 7 322151 8721 70597565
Prescribed overdose 20.44 13.60 201 321957 26980 70579306
Hepatitis acute 20.34 13.60 20 322138 13942 70592344
Thinking abnormal 20.32 13.60 15 322143 12036 70594250
Neoplasm malignant 20.30 13.60 210 321948 28564 70577722
Colon cancer 20.26 13.60 21 322137 14285 70592001
Tender joint count 20.25 13.60 9 322149 71 70606215
Coeliac disease 20.18 13.60 88 322070 8945 70597341
Sinus node dysfunction 20.18 13.60 4 322154 7165 70599121
Potentiating drug interaction 20.15 13.60 6 322152 8158 70598128
Tenderness 20.13 13.60 165 321993 21045 70585241
Cardiac tamponade 20.01 13.60 7 322151 8588 70597698
Mean cell haemoglobin concentration abnormal 20.01 13.60 11 322147 143 70606143
Restless legs syndrome 19.99 13.60 33 322125 18395 70587891
Device malfunction 19.94 13.60 35 322123 19049 70587237
Major depression 19.93 13.60 7 322151 8567 70597719
Hepatic ischaemia 19.75 13.60 24 322134 1015 70605271
Hepatic cirrhosis 19.69 13.60 220 321938 30511 70575775
Metabolic disorder 19.68 13.60 6 322152 8034 70598252
Hypertonia 19.66 13.60 3 322155 6495 70599791
Dermatitis acneiform 19.63 13.60 8 322150 8937 70597349
Enthesophyte 19.54 13.60 6 322152 13 70606273
Sensory loss 19.53 13.60 14 322144 11405 70594881
Intervertebral disc compression 19.50 13.60 24 322134 1029 70605257
Aortic valve incompetence 19.48 13.60 8 322150 8896 70597390
Drug specific antibody present 19.43 13.60 64 322094 5694 70600592
Brain herniation 19.33 13.60 4 322154 6952 70599334
Feeling cold 19.30 13.60 56 322102 25514 70580772
Transplant rejection 19.29 13.60 33 322125 18138 70588148
Paralysis 19.13 13.60 16 322142 12056 70594230
Injection site pain 19.10 13.60 398 321760 117221 70489065
Aortic arteriosclerosis 19.04 13.60 6 322152 7863 70598423
Presbyacusis 19.02 13.60 39 322119 2598 70603688
Feeling hot 19.01 13.60 136 322022 48534 70557752
Extrasystoles 19.00 13.60 4 322154 6870 70599416
Aplasia pure red cell 18.99 13.60 5 322153 7369 70598917
Lung consolidation 18.94 13.60 7 322151 8299 70597987
Jaundice cholestatic 18.91 13.60 9 322149 9175 70597111
Alanine aminotransferase increased 18.91 13.60 835 321323 146645 70459641
Lung infiltration 18.89 13.60 44 322114 21580 70584706
Ventricular arrhythmia 18.89 13.60 6 322152 7824 70598462
Normal newborn 18.85 13.60 3 322155 6297 70599989
Decubitus ulcer 18.81 13.60 22 322136 14169 70592117
Forced expiratory volume decreased 18.75 13.60 5 322153 7309 70598977
Arthritis infective 18.74 13.60 75 322083 7337 70598949
Pulmonary function test decreased 18.72 13.60 4 322154 6797 70599489
Allergy to chemicals 18.70 13.60 33 322125 1963 70604323
Pleural fibrosis 18.70 13.60 51 322107 4088 70602198
Peripheral coldness 18.67 13.60 23 322135 14477 70591809
Embolic stroke 18.66 13.60 5 322153 7284 70599002
Wheezing 18.61 13.60 308 321850 93862 70512424
Bacterial infection 18.58 13.60 60 322098 26432 70579854
Ocular hyperaemia 18.57 13.60 54 322104 24585 70581701
Neuralgia 18.56 13.60 67 322091 28536 70577750
Hepatic necrosis 18.54 13.60 8 322150 8638 70597648
Hiatus hernia 18.46 13.60 43 322115 21091 70585195
Oral disorder 18.45 13.60 87 322071 9142 70597144
Inflammatory pain 18.44 13.60 22 322136 913 70605373
Supraventricular extrasystoles 18.44 13.60 3 322155 6195 70600091
Urosepsis 18.40 13.60 52 322106 23897 70582389
Facial paralysis 18.37 13.60 39 322119 19769 70586517
Therapy change 18.35 13.60 4 322154 6705 70599581
Generalised oedema 18.31 13.60 45 322113 21663 70584623
Limb operation 18.24 13.60 42 322116 3030 70603256
Amylase increased 18.15 13.60 12 322146 10196 70596090
Hydrocephalus 18.12 13.60 7 322151 8078 70598208
Metastasis 18.10 13.60 3 322155 6111 70600175
Renal tubular disorder 18.08 13.60 3 322155 6107 70600179
Ammonia increased 18.08 13.60 5 322153 7133 70599153
Hypertransaminasaemia 18.06 13.60 9 322149 8934 70597352
Pyopneumothorax 18.01 13.60 8 322150 63 70606223
Pregnancy 17.95 13.60 176 321982 23605 70582681
Intestinal ischaemia 17.90 13.60 17 322141 12047 70594239
Thrombosis 17.88 13.60 238 321920 75167 70531119
Ventricular hypertrophy 17.86 13.60 4 322154 6580 70599706
Eyelid ptosis 17.79 13.60 12 322146 10090 70596196
Heart rate irregular 17.79 13.60 72 322086 29671 70576615
Eye disorder 17.78 13.60 158 322000 20627 70585659
Post procedural complication 17.67 13.60 47 322111 22034 70584252
Wheelchair user 17.64 13.60 58 322100 5156 70601130
Squamous cell carcinoma of skin 17.62 13.60 19 322139 12693 70593593
Dry eye 17.56 13.60 224 321934 32058 70574228
Oral discomfort 17.47 13.60 83 322075 8748 70597538
Immunosuppressant drug level increased 17.47 13.60 7 322151 7900 70598386
Blood lactic acid increased 17.47 13.60 15 322143 11158 70595128
Eye movement disorder 17.42 13.60 6 322152 7434 70598852
Rib fracture 17.39 13.60 58 322100 25298 70580988
Pulmonary alveolar haemorrhage 17.36 13.60 13 322145 10356 70595930
Steatohepatitis 17.36 13.60 20 322138 799 70605487
Spinal cord compression 17.34 13.60 3 322155 5925 70600361
Amenorrhoea 17.28 13.60 5 322153 6925 70599361
Dermatitis exfoliative generalised 17.19 13.60 4 322154 6410 70599876
Multiple-drug resistance 17.11 13.60 6 322152 7349 70598937
Arteriosclerosis 16.95 13.60 31 322127 16607 70589679
Concomitant disease aggravated 16.91 13.60 18 322140 12096 70594190
Hepatitis 16.89 13.60 320 321838 49660 70556626
Diarrhoea haemorrhagic 16.86 13.60 17 322141 11713 70594573
Inflammatory marker increased 16.80 13.60 85 322073 9189 70597097
Retinal haemorrhage 16.75 13.60 7 322151 7703 70598583
Odynophagia 16.73 13.60 13 322145 10162 70596124
Mycobacterium marinum infection 16.71 13.60 15 322143 443 70605843
Cataract 16.71 13.60 350 321808 55295 70550991
Ageusia 16.70 13.60 26 322132 14836 70591450
Viral infection 16.63 13.60 104 322054 38287 70567999
General physical health deterioration 16.63 13.60 1266 320892 234765 70371521
Flank pain 16.62 13.60 34 322124 17468 70588818
Food allergy 16.59 13.60 9 322149 8515 70597771
Tongue oedema 16.59 13.60 4 322154 6255 70600031
Gastric ulcer haemorrhage 16.57 13.60 9 322149 8509 70597777
Back disorder 16.53 13.60 93 322065 10471 70595815
Mood altered 16.52 13.60 31 322127 16444 70589842
Hyperventilation 16.48 13.60 6 322152 7180 70599106
Hepatic steatosis 16.48 13.60 230 321928 33583 70572703
Gastritis erosive 16.47 13.60 13 322145 10082 70596204
Vitreous floaters 16.42 13.60 5 322153 6699 70599587
Hepatic fibrosis 16.32 13.60 64 322094 6203 70600083
Feeding disorder 16.25 13.60 117 322041 14339 70591947
Interstitial lung disease 16.25 13.60 605 321553 104080 70502206
Joint noise 16.23 13.60 43 322115 3388 70602898
Malignant neoplasm of conjunctiva 16.22 13.60 7 322151 51 70606235
Elbow deformity 16.18 13.60 26 322132 1432 70604854
Urine analysis abnormal 16.18 13.60 4 322154 6150 70600136
Cartilage atrophy 16.17 13.60 10 322148 164 70606122
Swollen joint count 16.15 13.60 21 322137 952 70605334
Pneumonia bacterial 16.08 13.60 32 322126 16609 70589677
Stress at work 16.03 13.60 22 322136 1051 70605235
Pharyngeal oedema 15.93 13.60 124 322034 15572 70590714
Hip fracture 15.93 13.60 70 322088 28193 70578093
Blood phosphorus decreased 15.85 13.60 4 322154 6065 70600221
Nervousness 15.82 13.60 80 322078 31040 70575246
Pneumothorax 15.82 13.60 62 322096 25784 70580502
Pseudomonal sepsis 15.77 13.60 3 322155 5534 70600752
Thyroid disorder 15.69 13.60 106 322052 12726 70593560
Haemorrhoidal haemorrhage 15.65 13.60 4 322154 6015 70600271
CD4/CD8 ratio increased 15.65 13.60 5 322153 13 70606273
Device occlusion 15.64 13.60 15 322143 10580 70595706
Blood triglycerides increased 15.63 13.60 42 322116 19622 70586664
Portal hypertension 15.62 13.60 5 322153 6487 70599799
Tooth infection 15.59 13.60 128 322030 16335 70589951
Left ventricular hypertrophy 15.58 13.60 14 322144 10188 70596098
Gestational diabetes 15.58 13.60 4 322154 5997 70600289
Dermatitis exfoliative 15.50 13.60 15 322143 10536 70595750
Cholecystitis acute 15.47 13.60 19 322139 11975 70594311
Ossicle disorder 15.46 13.60 6 322152 32 70606254
Serum ferritin increased 15.46 13.60 11 322147 8994 70597292
Rheumatic disorder 15.42 13.60 34 322124 2382 70603904
Petit mal epilepsy 15.40 13.60 3 322155 5441 70600845
Vaginal haematoma 15.37 13.60 9 322149 133 70606153
Graft versus host disease in gastrointestinal tract 15.36 13.60 4 322154 5940 70600346
Pain in jaw 15.35 13.60 122 322036 42547 70563739
Incoherent 15.29 13.60 7 322151 7299 70598987
Hyperpyrexia 15.12 13.60 3 322155 5371 70600915
Non-small cell lung cancer 15.07 13.60 5 322153 6342 70599944
Pancreatic carcinoma 15.06 13.60 22 322136 12882 70593404
Large intestine polyp 14.99 13.60 18 322140 11458 70594828
Product monitoring error 14.97 13.60 6 322152 6770 70599516
Bowel movement irregularity 14.95 13.60 3 322155 5329 70600957
Choking 14.82 13.60 17 322141 11043 70595243
Dry throat 14.79 13.60 6 322152 6722 70599564
Splenic embolism 14.72 13.60 10 322148 194 70606092
Glaucoma 14.70 13.60 136 322022 17956 70588330
Hot flush 14.67 13.60 149 322009 49435 70556851
Sebaceous gland infection 14.64 13.60 9 322149 146 70606140
Pulmonary granuloma 14.63 13.60 29 322129 1885 70604401
Aspartate aminotransferase increased 14.57 13.60 711 321447 126267 70480019
Haemorrhagic stroke 14.54 13.60 15 322143 10227 70596059
Device related sepsis 14.53 13.60 4 322154 5724 70600562
Peripheral arterial occlusive disease 14.51 13.60 8 322150 7501 70598785
Splenomegaly 14.48 13.60 41 322117 18829 70587457
Gangrene 14.46 13.60 10 322148 8299 70597987
Thrombotic thrombocytopenic purpura 14.43 13.60 5 322153 6172 70600114
Liver disorder 14.39 13.60 374 321784 61194 70545092
Cardiac granuloma 14.38 13.60 4 322154 5 70606281
Nail operation 14.36 13.60 15 322143 536 70605750
Gastrointestinal perforation 14.35 13.60 4 322154 5677 70600609
Aortic aneurysm 14.34 13.60 9 322149 7864 70598422
Orthopnoea 14.26 13.60 13 322145 9395 70596891
Onychomadesis 14.21 13.60 46 322112 4055 70602231
Dermatitis contact 14.16 13.60 14 322144 9735 70596551
Oral surgery 14.14 13.60 20 322138 983 70605303
Gastrointestinal necrosis 14.10 13.60 3 322155 5115 70601171
Functional gastrointestinal disorder 14.09 13.60 49 322109 4482 70601804
Pseudomembranous colitis 14.08 13.60 3 322155 5108 70601178
Haemophagocytic lymphohistiocytosis 14.05 13.60 44 322114 19568 70586718
Accident 14.04 13.60 68 322090 7223 70599063
Blood magnesium increased 14.02 13.60 40 322118 3291 70602995
Polyneuropathy 14.00 13.60 50 322108 21365 70584921
Adenovirus infection 13.99 13.60 9 322149 7759 70598527
Product label confusion 13.98 13.60 18 322140 808 70605478
Anal fistula 13.96 13.60 5 322153 6045 70600241
Lacrimal disorder 13.95 13.60 14 322144 477 70605809
Aortic bruit 13.91 13.60 10 322148 213 70606073
Drug level above therapeutic 13.90 13.60 9 322149 7733 70598553
Cell-mediated cytotoxicity 13.87 13.60 6 322152 44 70606242
Systemic inflammatory response syndrome 13.78 13.60 17 322141 10695 70595591
Cytopenia 13.77 13.60 37 322121 17286 70589000
Leukoencephalopathy 13.76 13.60 8 322150 7286 70599000
Metastases to lymph nodes 13.73 13.60 13 322145 9225 70597061
Pyelonephritis acute 13.72 13.60 4 322154 5513 70600773
Rotator cuff syndrome 13.71 13.60 102 322056 12632 70593654
Taste disorder 13.69 13.60 19 322139 11366 70594920
Rebound effect 13.67 13.60 5 322153 5966 70600320
Expired product administered 13.65 13.60 6 322152 6407 70599879
Diffuse idiopathic skeletal hyperostosis 13.65 13.60 6 322152 46 70606240

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AA13 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Selective immunosuppressants
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
MeSH PA D004791 Enzyme Inhibitors
CHEBI has role CHEBI:35442 antiparasitic drugs
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory agent
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:35705 immunosuppressive agents
CHEBI has role CHEBI:37153 protein serine/threonine phosphatase inhibitors
CHEBI has role CHEBI:38637 tyrosine kinase inhibitors
CHEBI has role CHEBI:50266 Prodrugs
CHEBI has role CHEBI:50908 agente hepatotoxico
CHEBI has role CHEBI:68542 DHODH inhibitor
CHEBI has role CHEBI:68543 pyrimidine synthesis inhibitors
FDA EPC N0000175713 Antirheumatic Agent
FDA MoA N0000185501 Dihydroorotate Dehydrogenase Inhibitors
FDA EPC N0000185502 Pyrimidine Synthesis Inhibitor
CHEBI has role CHEBI:49103 drug metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Psoriasis with arthropathy indication 33339001
Rheumatoid arthritis indication 69896004 DOID:7148
Inactive tuberculosis contraindication 11999007
Agranulocytosis contraindication 17182001 DOID:12987
Acute tuberculosis contraindication 25629007
Immunosuppression contraindication 38013005
Hepatic failure contraindication 59927004
Chronic type B viral hepatitis contraindication 61977001
Acute infectious disease contraindication 63171007
Interstitial pneumonia contraindication 64667001
Aspergillosis contraindication 65553006 DOID:13564
Viral hepatitis type B contraindication 66071002 DOID:2043
Kidney disease contraindication 90708001 DOID:557
Pancytopenia contraindication 127034005 DOID:12450
Chronic hepatitis C contraindication 128302006
Liver function tests abnormal contraindication 166603001
Disease of liver contraindication 235856003 DOID:409
Acute hepatitis C contraindication 235866006
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Peripheral nerve disease contraindication 302226006
Neutropenic disorder contraindication 303011007 DOID:1227
Breastfeeding (mother) contraindication 413712001
Pneumocystosis jiroveci pneumonia contraindication 415125002 DOID:11339
Severe Bone Marrow Depression contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.31 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Dihydroorotate dehydrogenase (quinone), mitochondrial Enzyme INHIBITOR IC50 5 CHEMBL CHEMBL
Sodium-dependent noradrenaline transporter Transporter Ki 5.34 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Ki 5.64 DRUG MATRIX
Cytochrome P450 1A2 Enzyme IC50 6.30 DRUG MATRIX
Amine oxidase [flavin-containing] A Enzyme IC50 4.68 DRUG MATRIX
Sodium/nucleoside cotransporter 1 Transporter Ki 5.29 DRUG MATRIX
Dihydroorotate dehydrogenase (quinone), mitochondrial Enzyme IC50 8.05 CHEMBL
Dihydroorotate dehydrogenase (quinone), mitochondrial Enzyme IC50 7.52 CHEMBL

External reference:

IDSource
4021132 VUID
N0000148586 NUI
D00749 KEGG_DRUG
4021132 VANDF
4031717 VANDF
C0063041 UMLSCUI
CHEBI:6402 CHEBI
CHEBI:68540 CHEBI
CHEMBL960 ChEMBL_ID
DB01097 DRUGBANK_ID
D000077339 MESH_DESCRIPTOR_UI
3899 PUBCHEM_CID
6825 IUPHAR_LIGAND_ID
C527525 MESH_SUPPLEMENTAL_RECORD_UI
5079 INN_ID
G162GK9U4W UNII
1310520 RXNORM
11870 MMSL
28846 MMSL
63949 MMSL
7491 MMSL
d04349 MMSL
d07905 MMSL
007642 NDDF
014643 NDDF
109143003 SNOMEDCT_US
386981009 SNOMEDCT_US
703785006 SNOMEDCT_US
703786007 SNOMEDCT_US
C1718383 UMLSCUI
DB08880 DRUGBANK_ID
7761 INN_ID
54684141 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Arava HUMAN PRESCRIPTION DRUG LABEL 1 0088-2160 TABLET, FILM COATED 10 mg ORAL NDA 27 sections
Arava HUMAN PRESCRIPTION DRUG LABEL 1 0088-2160 TABLET, FILM COATED 10 mg ORAL NDA 27 sections
Arava HUMAN PRESCRIPTION DRUG LABEL 1 0088-2161 TABLET, FILM COATED 20 mg ORAL NDA 27 sections
Arava HUMAN PRESCRIPTION DRUG LABEL 1 0088-2161 TABLET, FILM COATED 20 mg ORAL NDA 27 sections
Arava HUMAN PRESCRIPTION DRUG LABEL 1 0088-2162 TABLET, FILM COATED 100 mg ORAL NDA 27 sections
Arava HUMAN PRESCRIPTION DRUG LABEL 1 0088-2162 TABLET, FILM COATED 100 mg ORAL NDA 27 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 0955-1735 TABLET, FILM COATED 10 mg ORAL NDA AUTHORIZED GENERIC 27 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 0955-1735 TABLET, FILM COATED 10 mg ORAL NDA AUTHORIZED GENERIC 27 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 0955-1737 TABLET, FILM COATED 20 mg ORAL NDA AUTHORIZED GENERIC 27 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 0955-1737 TABLET, FILM COATED 20 mg ORAL NDA AUTHORIZED GENERIC 27 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 10702-277 TABLET 10 mg ORAL ANDA 18 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 10702-278 TABLET 20 mg Oral ANDA 18 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 23155-043 TABLET 10 mg ORAL ANDA 23 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 23155-043 TABLET 10 mg ORAL ANDA 23 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 23155-044 TABLET 20 mg ORAL ANDA 23 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 23155-044 TABLET 20 mg ORAL ANDA 23 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 35573-447 TABLET, FILM COATED 10 mg ORAL ANDA 27 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 35573-448 TABLET, FILM COATED 20 mg ORAL ANDA 27 sections
LEFLUNOMIDE HUMAN PRESCRIPTION DRUG LABEL 1 42291-420 TABLET 10 mg ORAL ANDA 18 sections
LEFLUNOMIDE HUMAN PRESCRIPTION DRUG LABEL 1 42291-421 TABLET 20 mg ORAL ANDA 18 sections
Leflunomide Human Prescription Drug Label 1 46708-436 TABLET 10 mg ORAL ANDA 26 sections
Leflunomide Human Prescription Drug Label 1 46708-437 TABLET 20 mg ORAL ANDA 26 sections
Leflunomide Human Prescription Drug Label 1 50090-5992 TABLET, FILM COATED 20 mg ORAL ANDA 26 sections
LEFLUNOMIDE HUMAN PRESCRIPTION DRUG LABEL 1 50268-477 TABLET 10 mg ORAL ANDA 18 sections
LEFLUNOMIDE HUMAN PRESCRIPTION DRUG LABEL 1 50268-478 TABLET 20 mg ORAL ANDA 18 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 54868-2319 TABLET, FILM COATED 20 mg ORAL ANDA 26 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 54868-6170 TABLET, FILM COATED 10 mg ORAL ANDA 26 sections
Leflunomide Human Prescription Drug Label 1 59651-348 TABLET, FILM COATED 10 mg ORAL ANDA 26 sections
Leflunomide Human Prescription Drug Label 1 59651-349 TABLET, FILM COATED 20 mg ORAL ANDA 26 sections
LEFLUNOMIDE HUMAN PRESCRIPTION DRUG LABEL 1 60505-2502 TABLET 10 mg ORAL ANDA 18 sections