latanoprost 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
prostaglandins 1551 130209-82-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • roclanda
  • latanoprost
  • xalatan
  • (15R)-Latanoprost
  • PhXA41
A prostaglandin F analog used to treat OCULAR HYPERTENSION in patients with GLAUCOMA.
  • Molecular weight: 432.60
  • Formula: C26H40O5
  • CLOGP: 3.60
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 86.99
  • ALOGS: -4.53
  • ROTB: 14
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.05 mg/mL Benet LZ, Broccatelli F, Oprea TI
CL (Clearance) 6.70 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.10 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.28 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAPK7,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CG,PRKDC,SIK2,SYK,TEK,TGFBR1,ZAP70 29
kinase-selectivity-class AXL,GRK2 2
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Jan. 7, 2021 EMA AERIE PHARMACEUTICALS IRELAND LIMITED
June 5, 1996 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Eye irritation 1338.90 12.23 522 40297 33456 90554172
Intraocular pressure increased 936.49 12.23 271 40548 6822 90580806
Treatment failure 861.97 12.23 859 39960 303069 90284559
Eye pain 632.07 12.23 335 40484 43833 90543795
Glaucoma 594.83 12.23 254 40565 20501 90567127
Ocular hyperaemia 513.81 12.23 267 40552 33531 90554097
Visual acuity reduced 253.74 12.23 148 40671 23262 90564366
Vision blurred 209.04 12.23 253 40566 110040 90477588
Eye pruritus 193.44 12.23 135 40684 28892 90558736
Colitis microscopic 174.78 12.23 90 40729 11069 90576559
Product container issue 163.39 12.23 54 40765 2127 90585501
Cataract 159.30 12.23 179 40640 71913 90515715
Foreign body sensation in eyes 152.39 12.23 57 40762 3243 90584385
Toxic epidermal necrolysis 126.52 12.23 110 40709 32418 90555210
Maternal exposure during pregnancy 124.60 12.23 10 40809 360053 90227575
Glossodynia 116.95 12.23 7 40812 321772 90265856
Blindness 105.66 12.23 91 40728 26477 90561151
Thyroid disorder 105.33 12.23 77 40742 17708 90569920
Dry eye 104.99 12.23 130 40689 57801 90529827
Diverticulitis 104.61 12.23 115 40704 45072 90542556
Intraocular pressure test abnormal 101.57 12.23 23 40796 205 90587423
Systemic lupus erythematosus 101.29 12.23 20 40799 361876 90225752
Skin reaction 100.20 12.23 76 40743 18477 90569151
Infusion related reaction 97.64 12.23 33 40786 416747 90170881
Pericarditis 94.85 12.23 7 40812 270144 90317484
Eye disorder 93.40 12.23 86 40733 27304 90560324
Reaction to preservatives 89.86 12.23 21 40798 218 90587410
Eye discharge 86.28 12.23 51 40768 8207 90579421
Lacrimation increased 82.77 12.23 80 40739 26982 90560646
Ocular surface disease 81.98 12.23 16 40803 62 90587566
Ocular discomfort 81.76 12.23 45 40774 6325 90581303
Folliculitis 75.59 12.23 4 40815 204349 90383279
Eye swelling 75.43 12.23 79 40740 29307 90558321
Conjunctival hyperaemia 75.24 12.23 34 40785 3135 90584493
Epidermal necrosis 74.62 12.23 31 40788 2330 90585298
Choroidal effusion 73.27 12.23 23 40796 766 90586862
Corneal disorder 72.01 12.23 29 40790 2013 90585615
Corneal opacity 70.02 12.23 23 40796 888 90586740
Psoriatic arthropathy 69.64 12.23 10 40809 228325 90359303
Visual impairment 68.96 12.23 171 40648 132194 90455434
Product quality issue 67.37 12.23 125 40694 79200 90508428
Lower respiratory tract infection 65.75 12.23 16 40803 250643 90336985
Contraindicated product administered 65.70 12.23 31 40788 320108 90267520
Growth of eyelashes 64.47 12.23 16 40803 218 90587410
Arthropathy 62.99 12.23 44 40775 366198 90221430
Blepharitis 62.06 12.23 32 40787 3944 90583684
Joint swelling 61.56 12.23 82 40737 503218 90084410
Irritable bowel syndrome 61.17 12.23 10 40809 207438 90380190
Liver injury 61.07 12.23 4 40815 170563 90417065
Product delivery mechanism issue 60.53 12.23 18 40801 498 90587130
Infection 59.04 12.23 46 40773 362048 90225580
Product packaging quantity issue 57.35 12.23 23 40796 1579 90586049
Type 2 diabetes mellitus 57.31 12.23 11 40808 203233 90384395
Visual field defect 56.49 12.23 37 40782 7129 90580499
Choroidal detachment 56.34 12.23 15 40804 274 90587354
Fall 56.00 12.23 390 40429 481420 90106208
Hypotony of eye 54.92 12.23 14 40805 214 90587414
Corneal oedema 53.55 12.23 23 40796 1878 90585750
Completed suicide 53.14 12.23 3 40816 145055 90442573
Iridocyclitis 50.14 12.23 27 40792 3634 90583994
Product packaging issue 50.03 12.23 21 40798 1620 90586008
Discomfort 49.80 12.23 31 40788 274304 90313324
Macular hole 49.10 12.23 18 40801 967 90586661
Impaired healing 49.08 12.23 22 40797 234177 90353451
Bronchitis 48.14 12.23 165 40654 152762 90434866
Ill-defined disorder 48.09 12.23 12 40807 184879 90402749
Intraocular pressure decreased 47.26 12.23 11 40808 112 90587516
Intraocular pressure fluctuation 46.68 12.23 10 40809 67 90587561
Abnormal sensation in eye 46.33 12.23 21 40798 1950 90585678
Normal tension glaucoma 46.29 12.23 9 40810 34 90587594
Rash papular 45.71 12.23 51 40768 20304 90567324
Photophobia 45.57 12.23 52 40767 21217 90566411
Injury 45.52 12.23 16 40803 197333 90390295
Erythema of eyelid 44.37 12.23 24 40795 3259 90584369
Hyphaema 43.95 12.23 13 40806 353 90587275
Wound 43.91 12.23 43 40776 302937 90284691
Exposure during pregnancy 43.19 12.23 27 40792 238383 90349245
Toxicity to various agents 42.71 12.23 40 40779 287806 90299822
Product substitution issue 41.96 12.23 46 40773 17962 90569666
Haemoglobin decreased 41.91 12.23 164 40655 161792 90425836
Trabeculectomy 41.63 12.23 8 40811 28 90587600
Product administration error 41.11 12.23 55 40764 26368 90561260
Stomatitis 40.96 12.23 38 40781 274660 90312968
Product packaging difficult to open 40.87 12.23 10 40809 128 90587500
Blister 40.78 12.23 33 40786 254965 90332663
Eye allergy 40.67 12.23 17 40802 1298 90586330
Blepharal pigmentation 40.50 12.23 9 40810 73 90587555
Transient ischaemic attack 40.43 12.23 71 40748 43105 90544523
Blindness unilateral 40.25 12.23 31 40788 7705 90579923
Burns second degree 40.02 12.23 19 40800 1961 90585667
Iris hyperpigmentation 39.85 12.23 8 40811 37 90587591
Angle closure glaucoma 39.51 12.23 21 40798 2754 90584874
Cerebrovascular accident 39.49 12.23 134 40685 123399 90464229
Abdominal discomfort 39.38 12.23 99 40720 477229 90110399
Gastrointestinal disorder 38.87 12.23 35 40784 256652 90330976
Fibromyalgia 37.85 12.23 23 40796 206246 90381382
Conjunctival scar 37.82 12.23 8 40811 50 90587578
Therapeutic product effect decreased 37.29 12.23 42 40777 277529 90310099
Eyelid oedema 36.97 12.23 35 40784 11499 90576129
Product container seal issue 36.94 12.23 10 40809 195 90587433
Joint range of motion decreased 36.86 12.23 8 40811 135635 90451993
Iris atrophy 36.38 12.23 9 40810 121 90587507
Eyelash thickening 36.08 12.23 6 40813 6 90587622
Dental restoration failure 35.83 12.23 15 40804 1149 90586479
Eyelid margin crusting 35.80 12.23 17 40802 1755 90585873
Angioplasty 35.55 12.23 16 40803 1461 90586167
Corneal neovascularisation 35.04 12.23 9 40810 142 90587486
Rheumatoid arthritis 34.98 12.23 69 40750 362545 90225083
Corneal deposits 34.97 12.23 11 40808 369 90587259
Musculoskeletal stiffness 34.52 12.23 50 40769 296482 90291146
Product use issue 34.28 12.23 60 40759 329859 90257769
Eye colour change 34.14 12.23 11 40808 399 90587229
Wound infection 34.01 12.23 4 40815 106398 90481230
Peripheral vascular disorder 33.96 12.23 26 40793 6405 90581223
Product dose omission issue 33.75 12.23 236 40583 291451 90296177
Limb injury 33.72 12.23 55 40764 31453 90556175
Macular oedema 33.08 12.23 23 40796 4886 90582742
Cystoid macular oedema 33.06 12.23 17 40802 2083 90585545
Phlebitis 32.73 12.23 27 40792 7403 90580225
Product use complaint 32.22 12.23 20 40799 3513 90584115
Choking 32.04 12.23 33 40786 12000 90575628
Lip dry 31.77 12.23 4 40815 100951 90486677
Swelling 31.47 12.23 91 40728 418967 90168661
Hyponatraemia 31.18 12.23 131 40688 133407 90454221
Catarrh 30.96 12.23 15 40804 1619 90586009
Pain 30.72 12.23 294 40525 996047 89591581
Product complaint 30.61 12.23 34 40785 13466 90574162
Product package associated injury 30.02 12.23 6 40813 27 90587601
Procollagen type I C-terminal propeptide increased 30.02 12.23 6 40813 27 90587601
Serum procollagen type I N-terminal propeptide increased 29.84 12.23 6 40813 28 90587600
Bursitis 29.79 12.23 11 40808 131643 90455985
Cardiac failure congestive 29.75 12.23 105 40714 98589 90489039
Iris adhesions 29.71 12.23 10 40809 417 90587211
Spontaneous hyphaema 29.59 12.23 5 40814 6 90587622
Eye inflammation 29.41 12.23 26 40793 7825 90579803
Uveitis 29.30 12.23 36 40783 15867 90571761
Obesity 29.13 12.23 6 40813 105501 90482127
Thermal burns of eye 29.09 12.23 8 40811 166 90587462
Hypoacusis 28.97 12.23 48 40771 27802 90559826
Alopecia 28.76 12.23 120 40699 494951 90092677
Intestinal polyp 28.69 12.23 14 40805 1535 90586093
Mobility decreased 28.47 12.23 43 40776 250691 90336937
Meniscus injury 28.34 12.23 26 40793 8211 90579417
Product storage error 28.28 12.23 40 40779 20201 90567427
Nasal discharge discolouration 28.19 12.23 17 40802 2836 90584792
Achromotrichia acquired 28.04 12.23 5 40814 10 90587618
Ocular pemphigoid 27.90 12.23 7 40812 100 90587528
Syncope 27.81 12.23 126 40693 132537 90455091
Conjunctivitis allergic 27.59 12.23 13 40806 1319 90586309
Poor quality product administered 27.53 12.23 19 40800 3989 90583639
Inflammation 27.45 12.23 24 40795 178568 90409060
Duodenal ulcer haemorrhage 27.26 12.23 16 40803 2540 90585088
Febrile neutropenia 27.22 12.23 19 40800 158330 90429298
Peripheral venous disease 27.21 12.23 3 40816 83918 90503710
Punctate keratitis 27.02 12.23 11 40808 785 90586843
Tarsal tunnel syndrome 26.76 12.23 10 40809 567 90587061
Red blood cell sedimentation rate increased 26.66 12.23 3 40816 82592 90505036
Metamorphopsia 26.48 12.23 13 40806 1444 90586184
Eye operation 26.40 12.23 16 40803 2693 90584935
Cataract operation 26.32 12.23 22 40797 6141 90581487
Steroid dependence 26.32 12.23 15 40804 2254 90585374
Purpura senile 26.14 12.23 10 40809 605 90587023
Hyperaesthesia 26.09 12.23 28 40791 10674 90576954
Haemorrhage 25.55 12.23 79 40740 69290 90518338
Instillation site pain 25.37 12.23 11 40808 919 90586709
General physical health deterioration 25.30 12.23 79 40740 355036 90232592
Iris hypopigmentation 25.30 12.23 5 40814 21 90587607
Pyrexia 25.24 12.23 184 40635 660301 89927327
Hepatic enzyme increased 25.18 12.23 81 40738 360655 90226973
Palpitations 25.12 12.23 125 40694 136603 90451025
Product formulation issue 25.12 12.23 10 40809 673 90586955
C-reactive protein abnormal 25.11 12.23 13 40806 127416 90460212
Thyroxine decreased 25.10 12.23 10 40809 675 90586953
Maculopathy 24.94 12.23 15 40804 2491 90585137
Gingival pain 24.86 12.23 26 40793 9626 90578002
Tremor 24.67 12.23 135 40684 153038 90434590
Retinal detachment 24.38 12.23 22 40797 6800 90580828
Haemorrhage intracranial 24.26 12.23 32 40787 15130 90572498
Atrial flutter 24.23 12.23 27 40792 10731 90576897
Expired product administered 24.11 12.23 22 40797 6900 90580728
Foreign body in eye 23.84 12.23 7 40812 185 90587443
Weight increased 23.83 12.23 102 40717 417825 90169803
Conjunctivitis 23.82 12.23 43 40776 26663 90560965
Chronotropic incompetence 23.52 12.23 6 40813 92 90587536
Instillation site erythema 23.46 12.23 6 40813 93 90587535
Hypersensitivity 23.04 12.23 309 40510 454368 90133260
Rash erythematous 22.93 12.23 73 40746 65031 90522597
Intentional product use issue 22.92 12.23 39 40780 216853 90370775
Eye oedema 22.90 12.23 13 40806 1939 90585689
Instillation site irritation 22.81 12.23 7 40812 216 90587412
Epigastric discomfort 22.44 12.23 22 40797 7546 90580082
Product design issue 22.43 12.23 4 40815 8 90587620
Prescribed overdose 22.35 12.23 8 40811 97617 90490011
Floppy iris syndrome 22.21 12.23 6 40813 116 90587512
Ocular hypertension 21.92 12.23 12 40807 1668 90585960
Iritis 21.91 12.23 16 40803 3670 90583958
Retinopathy haemorrhagic 21.82 12.23 4 40815 10 90587618
Arthralgia 21.77 12.23 235 40584 778287 89809341
Pupillary disorder 21.47 12.23 7 40812 264 90587364
Eyelid disorder 21.44 12.23 13 40806 2190 90585438
Hypopnoea 21.42 12.23 17 40802 4414 90583214
Suicide attempt 21.42 12.23 4 40815 75395 90512233
Dysgeusia 21.39 12.23 62 40757 52498 90535130
Eyelid irritation 21.38 12.23 10 40809 998 90586630
Conjunctival follicles 21.04 12.23 4 40815 13 90587615
Corneal epithelium defect 20.93 12.23 8 40811 483 90587145
Hip fracture 20.77 12.23 46 40773 33031 90554597
Keratitis 20.73 12.23 16 40803 3990 90583638
Facial paralysis 20.68 12.23 30 40789 15504 90572124
Tinnitus 20.67 12.23 54 40765 43048 90544580
Vitreous floaters 20.64 12.23 21 40798 7528 90580100
Hallucination 20.59 12.23 71 40748 65888 90521740
Clostridium test positive 20.46 12.23 18 40801 5383 90582245
Conjunctival erosion 20.46 12.23 6 40813 158 90587470
Retinal disorder 20.44 12.23 12 40807 1907 90585721
Scleral hyperaemia 20.41 12.23 7 40812 309 90587319
Eye complication associated with device 20.39 12.23 4 40815 16 90587612
Body height decreased 20.34 12.23 26 40793 11923 90575705
Photocoagulation 20.12 12.23 3 40816 0 90587628
Parosmia 19.94 12.23 20 40799 7049 90580579
Musculoskeletal pain 19.79 12.23 29 40790 171222 90416406
Acute kidney injury 19.77 12.23 226 40593 320161 90267467
Hip arthroplasty 19.70 12.23 5 40814 76203 90511425
Pulmonary fibrosis 19.70 12.23 12 40807 107491 90480137
Atrial fibrillation 19.69 12.23 115 40704 133496 90454132
Blood cholesterol increased 19.68 12.23 40 40779 207972 90379656
Pulmonary congestion 19.56 12.23 33 40786 19400 90568228
Product closure removal difficult 19.50 12.23 4 40815 21 90587607
Lower limb fracture 19.41 12.23 7 40812 85006 90502622
Skin exfoliation 19.40 12.23 71 40748 67842 90519786
Glaucoma surgery 19.28 12.23 5 40814 82 90587546
Skin irritation 19.18 12.23 27 40792 13576 90574052
Ophthalmic herpes simplex 18.84 12.23 8 40811 635 90586993
Genital rash 18.72 12.23 8 40811 645 90586983
Superficial injury of eye 18.70 12.23 7 40812 399 90587229
Encephalitis 18.60 12.23 24 40795 11110 90576518
Vogt-Koyanagi-Harada disease 18.57 12.23 7 40812 407 90587221
Contusion 18.51 12.23 55 40764 251161 90336467
Arrhythmia 18.26 12.23 51 40768 42281 90545347
Drug-induced liver injury 18.12 12.23 9 40810 90309 90497319
Incorrect dose administered 18.08 12.23 77 40742 78853 90508775
Cyclothymic disorder 18.06 12.23 6 40813 240 90587388
Sleep disorder 17.96 12.23 39 40780 197991 90389637
Retinal vascular disorder 17.65 12.23 6 40813 258 90587370
Retinal tear 17.61 12.23 10 40809 1492 90586136
Acute generalised exanthematous pustulosis 17.57 12.23 26 40793 13677 90573951
Hypercholesterolaemia 17.48 12.23 12 40807 100880 90486748
Dacryostenosis acquired 17.37 12.23 8 40811 771 90586857
Genital erythema 17.34 12.23 4 40815 39 90587589
Instillation site reaction 17.32 12.23 7 40812 490 90587138
Thrombosis 17.20 12.23 72 40747 73179 90514449
Vitreous haemorrhage 16.99 12.23 12 40807 2614 90585014
Oedema 16.91 12.23 41 40778 200254 90387374
Urinary tract infection 16.84 12.23 211 40608 305421 90282207
Periorbital disorder 16.82 12.23 4 40815 45 90587583
Eye infection 16.79 12.23 26 40793 14228 90573400
Epilepsy 16.78 12.23 8 40811 82198 90505430
Tubulointerstitial nephritis 16.77 12.23 36 40783 25307 90562321
Resorption bone increased 16.72 12.23 9 40810 1210 90586418
Hepatic cirrhosis 16.64 12.23 4 40815 63249 90524379
Blood magnesium decreased 16.26 12.23 27 40792 15666 90571962
Ulcerative keratitis 16.16 12.23 13 40806 3440 90584188
Hyperkalaemia 16.16 12.23 65 40754 64899 90522729
Iris neovascularisation 16.15 12.23 4 40815 54 90587574
Catheter site pain 16.13 12.23 16 40803 5563 90582065
Corneal abrasion 16.08 12.23 9 40810 1307 90586321
Coronary artery disease 16.00 12.23 42 40777 33581 90554047
Diabetic ulcer 15.97 12.23 5 40814 165 90587463
Subacute kidney injury 15.96 12.23 3 40816 9 90587619
Pharyngeal enanthema 15.95 12.23 4 40815 57 90587571
Circumstance or information capable of leading to medication error 15.78 12.23 15 40804 4952 90582676
Corneal transplant 15.78 12.23 6 40813 357 90587271
Keratitis interstitial 15.72 12.23 3 40816 10 90587618
Chronic leukaemia 15.72 12.23 3 40816 10 90587618
Corectopia 15.72 12.23 3 40816 10 90587618
Reaction to excipient 15.64 12.23 10 40809 1850 90585778
Injury corneal 15.61 12.23 5 40814 178 90587450
Fasciitis 15.61 12.23 7 40812 634 90586994
Corneal degeneration 15.56 12.23 5 40814 180 90587448
Eye haemorrhage 15.54 12.23 21 40798 10159 90577469
Joint stiffness 15.32 12.23 8 40811 78034 90509594
Optic nerve cupping 15.30 12.23 3 40816 12 90587616
Visual field tests abnormal 15.18 12.23 4 40815 70 90587558
Chondropathy 15.15 12.23 11 40808 2501 90585127
Herpes ophthalmic 15.01 12.23 9 40810 1485 90586143
Product lot number issue 14.96 12.23 5 40814 204 90587424
Lung disorder 14.89 12.23 28 40791 149855 90437773
Splenic haemorrhage 14.80 12.23 5 40814 211 90587417
Repetitive strain injury 14.77 12.23 5 40814 212 90587416
Vestibular disorder 14.71 12.23 9 40810 1540 90586088
Liquid product physical issue 14.71 12.23 9 40810 1541 90586087
Crepitations 14.66 12.23 19 40800 8833 90578795
Reading disorder 14.63 12.23 8 40811 1110 90586518
Synovitis 14.51 12.23 88 40731 329664 90257964
Adenocarcinoma metastatic 14.47 12.23 5 40814 226 90587402
Blood albumin abnormal 14.42 12.23 8 40811 1141 90586487
Dizziness 14.35 12.23 357 40462 588927 89998701
Eyelid pain 14.27 12.23 7 40812 776 90586852
Glare 13.87 12.23 4 40815 99 90587529
Muscle atrophy 13.86 12.23 18 40801 8383 90579245
Meibomian gland dysfunction 13.78 12.23 5 40814 261 90587367
Rhinitis 13.59 12.23 23 40796 13549 90574079
Sinus disorder 13.41 12.23 40 40779 34407 90553221
Upper gastrointestinal haemorrhage 13.37 12.23 31 40788 22945 90564683
Device deposit issue 13.32 12.23 3 40816 26 90587602
Dysphonia 13.28 12.23 60 40759 63024 90524604
Ageusia 13.22 12.23 25 40794 16051 90571577
Skin discolouration 13.22 12.23 47 40772 44268 90543360
Blindness transient 13.08 12.23 13 40806 4530 90583098
Symblepharon 12.98 12.23 5 40814 308 90587320
Vertigo 12.94 12.23 64 40755 69747 90517881
Corneal striae 12.94 12.23 3 40816 30 90587598
Amnesia 12.90 12.23 18 40801 108487 90479141
Conjunctival oedema 12.86 12.23 7 40812 962 90586666
Pemphigoid 12.85 12.23 18 40801 9008 90578620
Eyelids pruritus 12.76 12.23 9 40810 1955 90585673
Overdose 12.75 12.23 33 40786 157676 90429952
Dark circles under eyes 12.65 12.23 6 40813 618 90587010
Choroid melanoma 12.44 12.23 3 40816 36 90587592
Cardiac amyloidosis 12.42 12.23 7 40812 1029 90586599
Corneal scar 12.37 12.23 4 40815 147 90587481

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Treatment failure 873.42 13.38 532 27569 62092 42531142
Intraocular pressure increased 758.15 13.38 246 27855 6187 42587047
Eye irritation 522.55 13.38 217 27884 11101 42582133
Eye pain 222.25 13.38 139 27962 16891 42576343
Ocular hyperaemia 185.23 13.38 121 27980 15842 42577392
Glaucoma 185.19 13.38 96 28005 8152 42585082
Visual acuity reduced 177.16 13.38 122 27979 17428 42575806
Burns second degree 166.40 13.38 81 28020 6015 42587219
Catarrh 164.78 13.38 80 28021 5906 42587328
Steroid dependence 158.89 13.38 81 28020 6641 42586593
Parosmia 157.00 13.38 84 28017 7607 42585627
Hypopnoea 149.51 13.38 82 28019 7800 42585434
Gingival pain 146.48 13.38 83 28018 8411 42584823
Vision blurred 138.79 13.38 174 27927 53525 42539709
Systemic lupus erythematosus 134.10 13.38 81 28020 9243 42583991
Rhinitis 127.37 13.38 86 28015 11891 42581343
Cardiac murmur 117.71 13.38 84 28017 12691 42580543
Bronchiectasis 114.51 13.38 95 28006 17924 42575310
Impaired work ability 107.96 13.38 78 28023 12013 42581221
Swollen tongue 104.89 13.38 97 28004 21134 42572100
Corneal oedema 104.13 13.38 39 28062 1509 42591725
Foreign body sensation in eyes 102.27 13.38 34 28067 921 42592313
Nightmare 96.85 13.38 100 28001 24912 42568322
Alcohol poisoning 96.71 13.38 61 28040 7513 42585721
Tinnitus 94.99 13.38 106 27995 28832 42564402
Product delivery mechanism issue 94.24 13.38 24 28077 242 42592992
Impaired quality of life 92.70 13.38 76 28025 14101 42579133
Corneal disorder 87.30 13.38 31 28070 1028 42592206
Frequent bowel movements 85.44 13.38 87 28014 21320 42571914
Cataract 80.35 13.38 100 28001 30504 42562730
Dysgeusia 77.68 13.38 104 27997 34085 42559149
Accidental overdose 76.68 13.38 94 28007 28236 42564998
Vertigo 75.78 13.38 103 27998 34244 42558990
Eczema 74.88 13.38 102 27999 33984 42559250
Migraine 74.80 13.38 88 28013 25326 42567908
Cystoid macular oedema 73.05 13.38 27 28074 1006 42592228
Visual impairment 72.89 13.38 114 27987 42999 42550235
Tubulointerstitial nephritis 71.72 13.38 96 28005 31452 42561782
Medication error 71.00 13.38 98 28003 33056 42560178
Product container issue 68.75 13.38 25 28076 889 42592345
Arthritis 68.04 13.38 109 27992 41956 42551278
Eye pruritus 65.99 13.38 57 28044 11355 42581879
Corneal opacity 60.70 13.38 21 28080 644 42592590
Choroidal effusion 60.20 13.38 17 28084 261 42592973
Palpitations 58.02 13.38 113 27988 50684 42542550
Cataract operation 57.61 13.38 25 28076 1422 42591812
Choroidal detachment 56.93 13.38 19 28082 521 42592713
Hypotony of eye 56.82 13.38 16 28085 243 42592991
Rectal haemorrhage 55.02 13.38 109 27992 49497 42543737
Intraocular pressure fluctuation 54.51 13.38 10 28091 14 42593220
Colitis ulcerative 53.99 13.38 76 28025 26099 42567135
Toxicity to various agents 53.00 13.38 44 28057 229092 42364142
Ectropion 52.68 13.38 14 28087 169 42593065
Ocular surface disease 48.85 13.38 12 28089 103 42593131
Adverse drug reaction 48.63 13.38 88 28013 37346 42555888
Stress 47.65 13.38 96 28005 44116 42549118
Completed suicide 45.95 13.38 5 28096 96460 42496774
Product quality issue 43.08 13.38 56 28045 17826 42575408
Lacrimation increased 41.92 13.38 45 28056 11713 42581521
Iridocyclitis 41.91 13.38 23 28078 2188 42591046
Blindness unilateral 41.91 13.38 32 28069 5356 42587878
Anterior chamber disorder 41.78 13.38 10 28091 76 42593158
Cerebrovascular accident 40.97 13.38 149 27952 97011 42496223
Confusional state 40.83 13.38 218 27883 167379 42425855
Hyphaema 40.76 13.38 16 28085 704 42592530
Haematochezia 39.89 13.38 106 27995 58330 42534904
Blepharitis 39.12 13.38 21 28080 1912 42591322
Eye disorder 38.88 13.38 43 28058 11569 42581665
Loss of personal independence in daily activities 38.81 13.38 95 28006 49721 42543513
Angle closure glaucoma 37.03 13.38 17 28084 1105 42592129
Conjunctival hyperaemia 36.64 13.38 24 28077 3152 42590082
Abdominal discomfort 36.57 13.38 121 27980 75134 42518100
Blindness 35.30 13.38 51 28050 17927 42575307
Ulcerative keratitis 34.90 13.38 20 28081 2068 42591166
Drug interaction 34.72 13.38 78 28023 266921 42326313
Corneal infiltrates 34.63 13.38 10 28091 167 42593067
Product packaging quantity issue 34.00 13.38 17 28084 1336 42591898
Intraocular pressure test abnormal 33.91 13.38 9 28092 108 42593126
Dry eye 33.43 13.38 46 28055 15460 42577774
Eye discharge 33.02 13.38 22 28079 2973 42590261
Punctate keratitis 32.94 13.38 12 28089 429 42592805
Macular oedema 31.80 13.38 23 28078 3546 42589688
Visual field defect 31.29 13.38 26 28075 4912 42588322
Growth of eyelashes 30.86 13.38 8 28093 87 42593147
Ophthalmic herpes simplex 30.80 13.38 11 28090 371 42592863
Intraocular pressure decreased 30.70 13.38 8 28093 89 42593145
Deep vein thrombosis 29.91 13.38 115 27986 76842 42516392
Hypotony maculopathy 29.88 13.38 7 28094 48 42593186
Thermal burns of eye 29.65 13.38 6 28095 18 42593216
Keratitis 29.52 13.38 17 28084 1774 42591460
Intentional product use issue 29.29 13.38 109 27992 71724 42521510
Inappropriate schedule of product administration 29.21 13.38 133 27968 95769 42497465
Uveitis 28.81 13.38 33 28068 9225 42584009
Conjunctival oedema 28.58 13.38 12 28089 629 42592605
Reaction to preservatives 27.81 13.38 7 28094 67 42593167
Trabeculectomy 27.74 13.38 6 28095 27 42593207
Trabeculoplasty 27.69 13.38 5 28096 6 42593228
Herpes ophthalmic 27.45 13.38 12 28089 695 42592539
Corneal neovascularisation 27.27 13.38 7 28094 73 42593161
Product formulation issue 26.01 13.38 12 28089 789 42592445
Instillation site pain 25.59 13.38 7 28094 95 42593139
Glaucoma surgery 25.51 13.38 5 28096 12 42593222
Ocular hypertension 24.80 13.38 13 28088 1128 42592106
Eye inflammation 24.78 13.38 19 28082 3199 42590035
Depression 24.51 13.38 141 27960 111222 42482012
Erythema of eyelid 24.07 13.38 14 28087 1489 42591745
Ophthalmoplegia 23.87 13.38 16 28085 2184 42591050
Glaucomatous optic disc atrophy 23.06 13.38 4 28097 3 42593231
Pain in extremity 23.00 13.38 174 27927 150430 42442804
Corneal infection 22.85 13.38 5 28096 24 42593210
Pyelitis 22.56 13.38 7 28094 151 42593083
Open angle glaucoma 22.51 13.38 8 28093 266 42592968
Eyelid margin crusting 22.38 13.38 10 28091 610 42592624
Vomiting 22.13 13.38 107 27994 289616 42303618
Photophobia 22.05 13.38 27 28074 8092 42585142
Multiple organ dysfunction syndrome 21.95 13.38 19 28082 97016 42496218
Febrile neutropenia 21.94 13.38 57 28044 185646 42407588
Infection 21.84 13.38 25 28076 112043 42481191
Dizziness 21.52 13.38 255 27846 248999 42344235
Corneal perforation 21.34 13.38 8 28093 310 42592924
Ocular discomfort 21.27 13.38 17 28084 3040 42590194
Weight decreased 21.26 13.38 220 27881 207728 42385506
Optic nerve injury 21.25 13.38 7 28094 184 42593050
Product substitution issue 20.68 13.38 31 28070 11259 42581975
Septic shock 20.67 13.38 18 28083 91654 42501580
Macular cyst 20.59 13.38 4 28097 9 42593225
Conjunctival disorder 20.57 13.38 6 28095 104 42593130
COVID-19 20.03 13.38 138 27963 115810 42477424
Instillation site erythema 20.02 13.38 4 28097 11 42593223
Fatigue 19.93 13.38 400 27701 435241 42157993
Abdominal pain 19.89 13.38 62 28039 190409 42402825
Corneal decompensation 19.76 13.38 5 28096 49 42593185
Photocoagulation 19.58 13.38 5 28096 51 42593183
Foetal exposure during pregnancy 18.99 13.38 4 28097 47307 42545927
Iris hyperpigmentation 18.98 13.38 3 28098 0 42593234
Prostaglandin analogue periorbitopathy 18.98 13.38 3 28098 0 42593234
Product container seal issue 18.87 13.38 4 28097 16 42593218
Vitreous adhesions 18.32 13.38 4 28097 19 42593215
Pulmonary embolism 18.14 13.38 138 27963 119474 42473760
Rash 17.95 13.38 269 27832 276685 42316549
Thrombocytopenia 17.78 13.38 65 28036 190214 42403020
Floppy iris syndrome 17.64 13.38 7 28094 317 42592917
C-reactive protein increased 17.60 13.38 10 28091 63550 42529684
Myoclonic dystonia 17.40 13.38 5 28096 82 42593152
Macular hole 17.20 13.38 7 28094 339 42592895
Myelosuppression 17.13 13.38 3 28098 40458 42552776
Eyelids pruritus 17.12 13.38 7 28094 343 42592891
Visual acuity tests abnormal 16.86 13.38 5 28096 92 42593142
Heart rate abnormal 16.76 13.38 13 28088 2226 42591008
Eye swelling 16.73 13.38 29 28072 11891 42581343
Corneal scar 16.67 13.38 6 28095 207 42593027
Vitreous haemorrhage 16.45 13.38 14 28087 2733 42590501
Bone marrow oedema 16.29 13.38 9 28092 868 42592366
Eyelid irritation 16.18 13.38 7 28094 395 42592839
Cornea verticillata 16.11 13.38 5 28096 108 42593126
Headache 16.09 13.38 234 27867 239135 42354099
Therapeutic product effect incomplete 15.90 13.38 14 28087 70925 42522309
Somnolence 15.72 13.38 152 27949 140953 42452281
Corneal bleeding 15.68 13.38 3 28098 6 42593228
Ascites 15.57 13.38 9 28092 56669 42536565
Corneal erosion 15.53 13.38 5 28096 122 42593112
Type V hyperlipidaemia 15.53 13.38 9 28092 951 42592283
Drug ineffective for unapproved indication 14.70 13.38 6 28095 46157 42547077
Product use complaint 14.66 13.38 12 28089 2219 42591015
Eye haemorrhage 14.66 13.38 17 28084 4813 42588421
Abnormal sensation in eye 14.46 13.38 8 28093 773 42592461
Neutropenia 14.44 13.38 75 28026 199356 42393878
Sepsis 14.41 13.38 75 28026 199259 42393975
Disease progression 14.13 13.38 48 28053 143608 42449626
Optic nerve cupping 14.13 13.38 4 28097 62 42593172
Fall 14.11 13.38 225 27876 234295 42358939
Vitreous disorder 14.10 13.38 5 28096 165 42593069
Pancytopenia 14.00 13.38 36 28065 117707 42475527
Choluria 13.88 13.38 5 28096 173 42593061
Blood magnesium decreased 13.84 13.38 21 28080 7705 42585529
Corneal endotheliitis 13.78 13.38 4 28097 68 42593166
Asthenopia 13.78 13.38 8 28093 848 42592386
Nausea 13.69 13.38 182 27919 396617 42196617
Scleral hyperaemia 13.68 13.38 4 28097 70 42593164
Funguria 13.47 13.38 4 28097 74 42593160

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Intraocular pressure increased 1044.25 11.69 331 53482 10545 110524941
Eye irritation 834.65 11.69 380 53433 33072 110502414
Glaucoma 546.50 11.69 251 53562 22266 110513220
Eye pain 423.61 11.69 278 53535 49821 110485665
Visual acuity reduced 343.45 11.69 207 53606 31966 110503520
Ocular hyperaemia 327.22 11.69 216 53597 39070 110496416
Burns second degree 225.30 11.69 98 53715 7635 110527851
Catarrh 213.85 11.69 93 53720 7242 110528244
Steroid dependence 204.15 11.69 94 53719 8375 110527111
Hypopnoea 186.34 11.69 97 53716 11283 110524203
Vision blurred 185.58 11.69 269 53544 128753 110406733
Parosmia 175.70 11.69 98 53715 13082 110522404
Gingival pain 162.12 11.69 99 53714 15637 110519849
Cataract 160.99 11.69 196 53617 79289 110456197
Corneal oedema 139.52 11.69 54 53759 3119 110532367
Rhinitis 132.04 11.69 100 53713 22445 110513041
Cardiac murmur 130.63 11.69 103 53710 24525 110510961
Ocular surface disease 127.24 11.69 27 53786 157 110535329
Colitis microscopic 124.67 11.69 79 53734 13315 110522171
Choroidal effusion 114.79 11.69 34 53779 856 110534630
Nightmare 111.59 11.69 115 53698 38748 110496738
Corneal disorder 109.95 11.69 43 53770 2554 110532932
Alcohol poisoning 109.25 11.69 63 53750 8957 110526529
Bronchiectasis 108.44 11.69 110 53703 36383 110499103
Choroidal detachment 106.19 11.69 31 53782 741 110534745
Foreign body sensation in eyes 106.17 11.69 45 53768 3289 110532197
Blindness 105.14 11.69 108 53705 36251 110499235
Impaired quality of life 105.13 11.69 99 53714 29918 110505568
Corneal opacity 99.38 11.69 33 53780 1218 110534268
Tubulointerstitial nephritis 98.93 11.69 127 53686 54157 110481329
Eye pruritus 97.76 11.69 99 53714 32676 110502810
Tinnitus 97.04 11.69 133 53680 60407 110475079
Impaired work ability 96.11 11.69 89 53724 26330 110509156
Swollen tongue 95.83 11.69 132 53681 60230 110475256
Cystoid macular oedema 93.19 11.69 39 53774 2761 110532725
Hypotony of eye 92.33 11.69 25 53788 450 110535036
Completed suicide 91.29 11.69 7 53806 242374 110293112
Maternal exposure during pregnancy 88.97 11.69 10 53803 254873 110280613
Dysgeusia 86.47 11.69 136 53677 69849 110465637
Cerebrovascular accident 85.65 11.69 237 53576 181047 110354439
Vertigo 84.91 11.69 152 53661 86718 110448768
Accidental overdose 81.76 11.69 113 53700 51721 110483765
Visual field defect 80.50 11.69 54 53759 10018 110525468
Angle closure glaucoma 78.63 11.69 37 53776 3462 110532024
Infusion related reaction 78.36 11.69 44 53769 381118 110154368
Blepharitis 77.97 11.69 40 53773 4512 110530974
Product delivery mechanism issue 77.02 11.69 19 53794 232 110535254
Pericarditis 75.46 11.69 9 53804 219105 110316381
Conjunctival hyperaemia 74.03 11.69 42 53771 5789 110529697
Eczema 73.88 11.69 129 53684 72164 110463322
Toxicity to various agents 73.79 11.69 75 53738 480480 110055006
Duodenal ulcer perforation 73.45 11.69 3 53810 177697 110357789
Visual impairment 72.88 11.69 185 53628 134243 110401243
Lacrimation increased 72.06 11.69 82 53731 30868 110504618
Glossodynia 71.99 11.69 11 53802 221993 110313493
Iridocyclitis 71.50 11.69 40 53773 5368 110530118
Diverticulitis 70.30 11.69 107 53706 53415 110482071
Intraocular pressure test abnormal 69.18 11.69 17 53796 204 110535282
Epidermal necrosis 67.76 11.69 32 53781 3018 110532468
Thyroid disorder 67.28 11.69 60 53753 16909 110518577
Toxic epidermal necrolysis 67.00 11.69 108 53705 56619 110478867
Intraocular pressure fluctuation 65.32 11.69 14 53799 86 110535400
Skin reaction 65.13 11.69 65 53748 21079 110514407
Trabeculectomy 65.08 11.69 13 53800 53 110535433
Infection 64.68 11.69 49 53764 362151 110173335
Palpitations 63.53 11.69 196 53617 159016 110376470
Eye disorder 62.96 11.69 74 53739 28832 110506654
Folliculitis 62.67 11.69 5 53808 167648 110367838
Macular hole 61.68 11.69 22 53791 1009 110534477
Intraocular pressure decreased 61.35 11.69 15 53798 176 110535310
Hyphaema 60.16 11.69 22 53791 1085 110534401
Fall 59.09 11.69 498 53315 602984 109932502
Rectal haemorrhage 58.90 11.69 159 53654 119674 110415812
Reaction to preservatives 56.31 11.69 15 53798 253 110535233
Eye discharge 56.11 11.69 41 53772 8713 110526773
Psoriatic arthropathy 54.89 11.69 14 53799 196747 110338739
Blindness unilateral 52.04 11.69 41 53772 9745 110525741
Corneal neovascularisation 49.80 11.69 13 53800 202 110535284
Product container issue 49.23 11.69 21 53792 1559 110533927
Product formulation issue 49.21 11.69 20 53793 1314 110534172
Irritable bowel syndrome 49.17 11.69 10 53803 164205 110371281
Ulcerative keratitis 49.13 11.69 30 53783 4736 110530750
Stomatitis 48.95 11.69 36 53777 270206 110265280
Frequent bowel movements 48.16 11.69 107 53706 71283 110464203
Punctate keratitis 47.69 11.69 19 53794 1185 110534301
Deep vein thrombosis 47.49 11.69 163 53650 139724 110395762
Lower respiratory tract infection 47.21 11.69 30 53783 243076 110292410
Impaired healing 46.05 11.69 19 53794 196698 110338788
Dry eye 45.05 11.69 90 53723 55703 110479783
Eye inflammation 43.63 11.69 36 53777 9135 110526351
Floppy iris syndrome 43.38 11.69 13 53800 341 110535145
Bronchitis 43.24 11.69 171 53642 156861 110378625
Uveitis 43.06 11.69 53 53760 21657 110513829
Joint swelling 42.82 11.69 95 53718 442750 110092736
Ill-defined disorder 42.16 11.69 12 53801 156841 110378645
Keratitis 42.12 11.69 28 53785 5116 110530370
Eye swelling 41.89 11.69 65 53748 32983 110502503
Ophthalmic herpes simplex 41.77 11.69 16 53797 898 110534588
Arthropathy 41.72 11.69 47 53766 287475 110248011
Injury 41.69 11.69 17 53796 177248 110358238
Type 2 diabetes mellitus 41.68 11.69 17 53796 177215 110358271
Iris hyperpigmentation 41.47 11.69 8 53805 26 110535460
Product substitution issue 40.52 11.69 53 53760 23008 110512478
Inappropriate schedule of product administration 40.35 11.69 201 53612 203436 110332050
Iris atrophy 40.31 11.69 11 53802 204 110535282
Contraindicated product administered 40.09 11.69 37 53776 248230 110287256
Adverse drug reaction 39.38 11.69 127 53686 105432 110430054
Macular oedema 38.81 11.69 30 53783 6936 110528550
Haemoglobin decreased 38.81 11.69 230 53583 248497 110286989
Arthritis 38.74 11.69 173 53640 167413 110368073
Stress 37.73 11.69 125 53688 105223 110430263
Instillation site pain 37.50 11.69 14 53799 732 110534754
Joint range of motion decreased 37.35 11.69 7 53806 121825 110413661
Photophobia 35.95 11.69 53 53760 25718 110509768
Intentional overdose 35.87 11.69 10 53803 132491 110402995
Product quality issue 35.43 11.69 100 53713 77199 110458287
Mobility decreased 35.33 11.69 38 53775 237384 110298102
Instillation site erythema 35.05 11.69 8 53805 68 110535418
Dental restoration failure 34.93 11.69 15 53798 1132 110534354
Pulmonary embolism 34.54 11.69 200 53613 214274 110321212
Medication error 33.36 11.69 120 53693 105246 110430240
Anterior chamber disorder 33.24 11.69 9 53804 162 110535324
Rash papular 33.15 11.69 53 53760 27586 110507900
Wound infection 33.11 11.69 4 53809 96461 110439025
Corneal deposits 32.96 11.69 12 53801 584 110534902
Transient ischaemic attack 32.54 11.69 86 53727 63896 110471590
Colitis ulcerative 32.49 11.69 97 53716 77266 110458220
Lip dry 32.34 11.69 5 53808 100078 110435408
Cataract operation 32.05 11.69 25 53788 5858 110529628
Growth of eyelashes 31.98 11.69 9 53804 188 110535298
Arrhythmia 31.88 11.69 90 53723 69485 110466001
Iris adhesions 31.79 11.69 12 53801 647 110534839
Photocoagulation 31.75 11.69 7 53806 50 110535436
Ocular discomfort 31.52 11.69 29 53784 8504 110526982
Gastrointestinal disorder 31.48 11.69 43 53770 241909 110293577
Liver injury 31.40 11.69 17 53796 150396 110385090
Discomfort 31.25 11.69 35 53778 214672 110320814
Haematochezia 31.15 11.69 125 53688 115399 110420087
Corneal scar 31.13 11.69 10 53803 332 110535154
Normal tension glaucoma 30.83 11.69 7 53806 58 110535428
Product complaint 30.81 11.69 36 53777 13936 110521550
Blood magnesium decreased 30.64 11.69 43 53770 19953 110515533
Mucosal inflammation 30.62 11.69 5 53808 96136 110439350
Conjunctival oedema 30.55 11.69 15 53798 1541 110533945
Ectropion 30.54 11.69 11 53802 519 110534967
Corneal infiltrates 30.46 11.69 10 53803 356 110535130
Therapeutic product effect decreased 30.22 11.69 45 53768 244271 110291215
Angioplasty 29.99 11.69 16 53797 1955 110533531
Obesity 29.86 11.69 9 53804 113342 110422144
Febrile neutropenia 29.75 11.69 69 53744 316698 110218788
Open angle glaucoma 29.69 11.69 11 53802 563 110534923
Night sweats 29.68 11.69 14 53799 133969 110401517
Bursitis 29.68 11.69 13 53800 129905 110405581
Ocular hypertension 29.64 11.69 17 53796 2391 110533095
Limb injury 29.53 11.69 60 53753 37576 110497910
Fibromyalgia 29.37 11.69 24 53789 170885 110364601
Thermal burns of eye 29.24 11.69 8 53805 150 110535336
Serum procollagen type I N-terminal propeptide increased 29.20 11.69 6 53807 29 110535457
Procollagen type I C-terminal propeptide increased 28.87 11.69 6 53807 31 110535455
Hypotony maculopathy 28.87 11.69 6 53807 31 110535455
Maculopathy 28.53 11.69 18 53795 3009 110532477
Hepatic enzyme increased 28.48 11.69 72 53741 320820 110214666
Abnormal sensation in eye 28.44 11.69 16 53797 2170 110533316
Product use issue 28.39 11.69 69 53744 311626 110223860
Rheumatoid arthritis 28.35 11.69 65 53748 299548 110235938
Dacryostenosis acquired 27.81 11.69 11 53802 673 110534813
Peripheral vascular disorder 27.59 11.69 27 53786 8549 110526937
Acute kidney injury 27.50 11.69 448 53365 634982 109900504
Glaucoma surgery 27.17 11.69 7 53806 103 110535383
Intestinal polyp 26.87 11.69 16 53797 2413 110533073
Spontaneous hyphaema 26.48 11.69 5 53808 14 110535472
Phlebitis 26.24 11.69 28 53785 9813 110525673
Blister 26.11 11.69 44 53769 227332 110308154
Vitreous haemorrhage 25.96 11.69 20 53793 4600 110530886
Dizziness 25.81 11.69 480 53333 697713 109837773
Exposure during pregnancy 25.80 11.69 26 53787 167398 110368088
Myelosuppression 25.76 11.69 7 53806 94333 110441153
Wound 25.44 11.69 47 53766 234390 110301096
Multiple organ dysfunction syndrome 25.21 11.69 22 53791 151688 110383798
Nasal discharge discolouration 25.19 11.69 17 53796 3184 110532302
Swelling 25.19 11.69 87 53726 350954 110184532
Conjunctival follicles 25.11 11.69 5 53808 20 110535466
Visual field tests abnormal 25.11 11.69 5 53808 20 110535466
Red blood cell sedimentation rate increased 25.10 11.69 4 53809 78298 110457188
Arthralgia 24.85 11.69 251 53562 779381 109756105
Hyperaesthesia 24.57 11.69 33 53780 14694 110520792
Inflammation 24.47 11.69 35 53778 193203 110342283
Weight increased 24.41 11.69 113 53700 419531 110115955
Achromotrichia acquired 24.37 11.69 5 53808 24 110535462
Erythema of eyelid 24.33 11.69 18 53795 3897 110531589
International normalised ratio increased 24.29 11.69 95 53718 86677 110448809
Glaucomatous optic disc atrophy 24.28 11.69 4 53809 3 110535483
Hyponatraemia 24.16 11.69 185 53628 217468 110318018
Metamorphopsia 24.13 11.69 13 53800 1620 110533866
Instillation site irritation 24.03 11.69 7 53806 166 110535320
Choking 23.91 11.69 33 53780 15077 110520409
Musculoskeletal stiffness 23.89 11.69 64 53749 279758 110255728
Poor quality product administered 23.73 11.69 19 53794 4622 110530864
Ophthalmoplegia 23.60 11.69 17 53796 3533 110531953
Eye oedema 23.56 11.69 15 53798 2547 110532939
Confusional state 23.55 11.69 339 53474 468341 110067145
Retinal detachment 23.48 11.69 28 53785 11072 110524414
Keratitis interstitial 23.43 11.69 5 53808 30 110535456
Conjunctivitis 23.18 11.69 51 53762 33741 110501745
Alopecia 23.18 11.69 95 53718 364658 110170828
Tarsal tunnel syndrome 22.92 11.69 9 53804 540 110534946
Epigastric discomfort 22.90 11.69 25 53788 8990 110526496
COVID-19 22.73 11.69 200 53613 244860 110290626
Herpes ophthalmic 22.53 11.69 13 53800 1849 110533637
Eyelid ptosis 22.44 11.69 30 53783 13297 110522189
Meniscus injury 22.26 11.69 23 53790 7770 110527716
Corneal infection 21.95 11.69 6 53807 112 110535374
Purpura senile 21.93 11.69 9 53804 606 110534880
Ocular pemphigoid 21.92 11.69 7 53806 228 110535258
Cardiac failure congestive 21.87 11.69 137 53676 150863 110384623
Atrial flutter 21.86 11.69 41 53772 24221 110511265
Heart rate abnormal 21.83 11.69 22 53791 7216 110528270
Autoimmune disorder 21.78 11.69 3 53810 65480 110470006
Corneal epithelium defect 21.60 11.69 10 53803 902 110534584
Chronotropic incompetence 21.52 11.69 6 53807 121 110535365
Thyroxine decreased 21.51 11.69 10 53803 910 110534576
Blepharal pigmentation 21.36 11.69 5 53808 48 110535438
Liver disorder 20.90 11.69 23 53790 142220 110393266
Keratopathy 20.48 11.69 11 53802 1362 110534124
Abdominal pain 20.37 11.69 156 53657 512833 110022653
Product packaging quantity issue 20.29 11.69 12 53801 1787 110533699
Cornea verticillata 19.80 11.69 7 53806 313 110535173
Eye colour change 19.75 11.69 8 53805 521 110534965
Scleral hyperaemia 19.65 11.69 7 53806 320 110535166
Weight decreased 19.48 11.69 328 53485 467729 110067757
Eyelid disorder 19.47 11.69 13 53800 2392 110533094
Bradycardia 19.43 11.69 136 53677 155381 110380105
Eyelid oedema 19.32 11.69 30 53783 15232 110520254
Conjunctival scar 19.14 11.69 7 53806 345 110535141
Pain in extremity 19.07 11.69 338 53475 486780 110048706
Eye haemorrhage 19.06 11.69 26 53787 11748 110523738
C-reactive protein abnormal 19.02 11.69 21 53792 129674 110405812
Incorrect route of product administration 18.97 11.69 4 53809 64057 110471429
Meibomianitis 18.79 11.69 5 53808 84 110535402
Myoclonic dystonia 18.79 11.69 5 53808 84 110535402
Loss of personal independence in daily activities 18.63 11.69 131 53682 149889 110385597
Suicide attempt 18.42 11.69 14 53799 103380 110432106
Lower limb fracture 18.08 11.69 7 53806 75341 110460145
Corneal transplant 17.89 11.69 7 53806 416 110535070
Pyelitis 17.81 11.69 7 53806 421 110535065
Plasma cell myeloma 17.69 11.69 69 53744 62867 110472619
Corneal degeneration 17.66 11.69 6 53807 238 110535248
Hip fracture 17.62 11.69 47 53766 35104 110500382
Hypoacusis 17.59 11.69 47 53766 35144 110500342
Iritis 17.56 11.69 16 53797 4636 110530850
Blood cholesterol increased 17.54 11.69 40 53773 184745 110350741
Overdose 17.40 11.69 57 53756 233737 110301749
Urticaria 17.29 11.69 88 53725 318769 110216717
Retinal disorder 17.26 11.69 12 53801 2358 110533128
Optic nerve injury 17.22 11.69 8 53805 727 110534759
Encephalitis 17.18 11.69 32 53781 18807 110516679
Blepharospasm 17.14 11.69 3 53810 54848 110480638
Eyelid pain 16.87 11.69 8 53805 761 110534725
Retinal tear 16.77 11.69 11 53802 1966 110533520
Sinus disorder 16.65 11.69 44 53769 32684 110502802
Product dose omission issue 16.65 11.69 234 53579 321548 110213938
Eyelid margin crusting 16.57 11.69 11 53802 2005 110533481
Product container seal issue 16.51 11.69 5 53808 136 110535350
Skin irritation 16.51 11.69 29 53784 16290 110519196
Nail disorder 16.39 11.69 4 53809 57931 110477555
Blood albumin abnormal 16.19 11.69 8 53805 833 110534653
Epilepsy 16.09 11.69 15 53798 100194 110435292
Clostridium test positive 16.06 11.69 23 53790 10870 110524616
Anterior chamber cell 16.06 11.69 9 53804 1212 110534274
Sinusitis 16.02 11.69 82 53731 296606 110238880
Macular cyst 15.98 11.69 4 53809 52 110535434
Hallucination 15.93 11.69 94 53719 101338 110434148
Atrioventricular block complete 15.74 11.69 32 53781 20050 110515436
Retinoschisis 15.71 11.69 4 53809 56 110535430
Somnolence 15.67 11.69 217 53596 297232 110238254
Flat anterior chamber of eye 15.56 11.69 5 53808 166 110535320
Corectopia 15.49 11.69 3 53810 10 110535476
Listeriosis 15.42 11.69 12 53801 2802 110532684
Prescribed overdose 15.42 11.69 12 53801 87569 110447917
Vogt-Koyanagi-Harada disease 15.36 11.69 7 53806 609 110534877
Genital rash 15.31 11.69 9 53804 1326 110534160
Hypercholesterolaemia 15.30 11.69 13 53800 90824 110444662
Prostaglandin analogue periorbitopathy 15.27 11.69 3 53810 11 110535475
Corneal perforation 15.22 11.69 8 53805 948 110534538
Vitreous adhesions 15.21 11.69 4 53809 64 110535422
Body height decreased 15.13 11.69 22 53791 10541 110524945
Hepatic cirrhosis 15.08 11.69 7 53806 67619 110467867
Hepatotoxicity 15.03 11.69 6 53807 63394 110472092
Septic shock 15.03 11.69 34 53779 157494 110377992
Rash erythematous 14.96 11.69 79 53734 81753 110453733
Cytomegalovirus infection 14.94 11.69 4 53809 54440 110481046
Vitreous disorder 14.90 11.69 6 53807 385 110535101
Pharyngeal enanthema 14.88 11.69 4 53809 70 110535416
Iris hypopigmentation 14.88 11.69 4 53809 70 110535416
Retinal artery occlusion 14.85 11.69 14 53799 4235 110531251
Ascites 14.77 11.69 14 53799 92794 110442692
Syncope 14.69 11.69 157 53656 202379 110333107
Hypopyon 14.68 11.69 9 53804 1431 110534055
Retinal vascular disorder 14.64 11.69 6 53807 403 110535083
Superficial injury of eye 14.62 11.69 6 53807 404 110535082
Optic nerve cupping 14.52 11.69 4 53809 77 110535409
Corneal pigmentation 14.52 11.69 3 53810 15 110535471
Eye allergy 14.46 11.69 8 53805 1051 110534435
Vertebral end plate inflammation 14.42 11.69 5 53808 211 110535275
Subacute kidney injury 14.36 11.69 3 53810 16 110535470
Haemorrhage 14.34 11.69 95 53718 106597 110428889
Conjunctival disorder 14.32 11.69 6 53807 426 110535060
Resorption bone increased 14.15 11.69 9 53804 1525 110533961
Diabetic ulcer 14.13 11.69 5 53808 224 110535262
Corneal decompensation 14.10 11.69 4 53809 86 110535400
Apathy 14.08 11.69 27 53786 16212 110519274
Acute generalised exanthematous pustulosis 14.08 11.69 32 53781 21632 110513854
Repetitive strain injury 14.07 11.69 5 53808 227 110535259
Conjunctivochalasis 14.06 11.69 3 53810 18 110535468
Musculoskeletal pain 14.05 11.69 44 53769 182979 110352507
Lung disorder 14.03 11.69 43 53770 180004 110355482
Atrial fibrillation 13.96 11.69 172 53641 229470 110306016
General physical health deterioration 13.90 11.69 136 53677 425159 110110327
Facial paralysis 13.82 11.69 34 53779 24180 110511306
Eye operation 13.81 11.69 11 53802 2656 110532830
Haemorrhage intracranial 13.79 11.69 38 53775 28931 110506555
Intraocular pressure test 13.77 11.69 4 53809 94 110535392
Hip arthroplasty 13.70 11.69 5 53808 55808 110479678
Conjunctival erosion 13.61 11.69 5 53808 250 110535236
Duodenal ulcer haemorrhage 13.39 11.69 18 53795 8019 110527467
Nasopharyngitis 13.36 11.69 125 53688 394236 110141250
Corneal lesion 13.35 11.69 4 53809 105 110535381
Exostosis 13.34 11.69 3 53810 45953 110489533
Ocular rosacea 13.31 11.69 3 53810 24 110535462
Retinopathy haemorrhagic 13.27 11.69 4 53809 107 110535379
Hyperkalaemia 13.20 11.69 112 53701 135684 110399802
Product administration error 13.18 11.69 44 53769 37173 110498313
Endophthalmitis 13.13 11.69 18 53795 8169 110527317
Chondropathy 13.04 11.69 11 53802 2876 110532610
Peripheral venous disease 13.03 11.69 13 53800 84104 110451382
Synovitis 13.03 11.69 79 53734 274013 110261473
Skin exfoliation 12.98 11.69 80 53733 87571 110447915
Corneal thickening 12.89 11.69 3 53810 28 110535458
Upper respiratory tract infection 12.81 11.69 28 53785 131300 110404186
Death 12.75 11.69 437 53376 698432 109837054
Ageusia 12.75 11.69 29 53784 19616 110515870
Corneal endotheliitis 12.71 11.69 4 53809 124 110535362
Meibomian gland dysfunction 12.53 11.69 5 53808 313 110535173
Eye infection 12.42 11.69 24 53789 14494 110520992
Corneal abrasion 12.34 11.69 8 53805 1401 110534085
Depression 12.33 11.69 220 53593 317115 110218371
Coronary artery disease 12.28 11.69 68 53745 71622 110463864
Haemangioma of liver 12.23 11.69 8 53805 1422 110534064
Abdominal distension 12.14 11.69 44 53769 175059 110360427
Instillation site reaction 11.97 11.69 5 53808 352 110535134
Device deposit issue 11.96 11.69 4 53809 151 110535335
Intracranial haematoma 11.93 11.69 7 53806 1027 110534459
Vestibular disorder 11.83 11.69 10 53803 2622 110532864
Upper gastrointestinal haemorrhage 11.78 11.69 52 53761 50044 110485442
Reaction to excipient 11.76 11.69 9 53804 2050 110533436
Brain stem haematoma 11.74 11.69 4 53809 160 110535326
Oral mucosal discolouration 11.71 11.69 5 53808 372 110535114

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC S01EE01 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIGLAUCOMA PREPARATIONS AND MIOTICS
Prostaglandin analogues
ATC S01EE51 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIGLAUCOMA PREPARATIONS AND MIOTICS
Prostaglandin analogues
ATC S01EE52 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIGLAUCOMA PREPARATIONS AND MIOTICS
Prostaglandin analogues
FDA CS M0017805 Prostaglandins
FDA EPC N0000175454 Prostaglandin Analog
MeSH PA D009883 Ophthalmic Solutions
CHEBI has role CHEBI:23018 EC 4.2.1.1 (carbonic anhydrase) inhibitor
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:39456 antiglaucoma drug
CHEBI has role CHEBI:50266 prodrug

Related Drugs by ATC class:

S01EE Prostaglandin analogues 6 drugs
bimatoprostdorzolamidelatanoprostene bunodnetarsudiltafluprosttravoprost

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ocular hypertension indication 4210003 DOID:9282
Open-angle glaucoma indication 84494001 DOID:1067
Conjunctivitis contraindication 9826008 DOID:6195
Aphakia contraindication 24010005
Macular retinal edema contraindication 37231002 DOID:4449
Iritis contraindication 65074000 DOID:1406
Pseudophakia contraindication 95217000
Uveitis contraindication 128473001 DOID:13141
Cystoid macular edema contraindication 193387007 DOID:4447
Disorder of macula of retina contraindication 312999006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
0.005%;EQ 0.02% BASE ROCKLATAN ALCON LABS INC N208259 March 12, 2019 RX SOLUTION/DROPS OPHTHALMIC 10532993 July 11, 2026 REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%;EQ 0.02% BASE ROCKLATAN ALCON LABS INC N208259 March 12, 2019 RX SOLUTION/DROPS OPHTHALMIC 10882840 July 11, 2026 REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%;EQ 0.02% BASE ROCKLATAN ALCON LABS INC N208259 March 12, 2019 RX SOLUTION/DROPS OPHTHALMIC 11021456 July 11, 2026 REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%;EQ 0.02% BASE ROCKLATAN ALCON LABS INC N208259 March 12, 2019 RX SOLUTION/DROPS OPHTHALMIC 8450344 July 11, 2026 REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%;EQ 0.02% BASE ROCKLATAN ALCON LABS INC N208259 March 12, 2019 RX SOLUTION/DROPS OPHTHALMIC 9096569 July 11, 2026 REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005% XELPROS SUN PHARM N206185 Sept. 12, 2018 DISCN EMULSION OPHTHALMIC 9539262 Oct. 15, 2028 REDUCING ELEVATED INTRAOCULAR PRESSURE IN PATIENTS WITH OPEN-ANGLE GLAUCOMA OR OCULAR HYPERTENSION
0.005%;EQ 0.02% BASE ROCKLATAN ALCON LABS INC N208259 March 12, 2019 RX SOLUTION/DROPS OPHTHALMIC 10174017 Jan. 27, 2030 REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%;EQ 0.02% BASE ROCKLATAN ALCON LABS INC N208259 March 12, 2019 RX SOLUTION/DROPS OPHTHALMIC 10654844 Jan. 27, 2030 REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%;EQ 0.02% BASE ROCKLATAN ALCON LABS INC N208259 March 12, 2019 RX SOLUTION/DROPS OPHTHALMIC 11028081 Jan. 27, 2030 REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%;EQ 0.02% BASE ROCKLATAN ALCON LABS INC N208259 March 12, 2019 RX SOLUTION/DROPS OPHTHALMIC 11618748 Jan. 27, 2030 REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%;EQ 0.02% BASE ROCKLATAN ALCON LABS INC N208259 March 12, 2019 RX SOLUTION/DROPS OPHTHALMIC 8394826 Nov. 10, 2030 REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005% IYUZEH THEA PHARMA N216472 Dec. 13, 2022 RX SOLUTION/DROPS OPHTHALMIC 8637054 July 8, 2031 TOPICAL TREATMENT OF OCULAR HYPERTENSION AND GLAUCOMA
0.005%;EQ 0.02% BASE ROCKLATAN ALCON LABS INC N208259 March 12, 2019 RX SOLUTION/DROPS OPHTHALMIC 10588901 March 14, 2034 REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%;EQ 0.02% BASE ROCKLATAN ALCON LABS INC N208259 March 12, 2019 RX SOLUTION/DROPS OPHTHALMIC 11020385 March 14, 2034 REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%;EQ 0.02% BASE ROCKLATAN ALCON LABS INC N208259 March 12, 2019 RX SOLUTION/DROPS OPHTHALMIC 9931336 March 14, 2034 REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%;EQ 0.02% BASE ROCKLATAN ALCON LABS INC N208259 March 12, 2019 RX SOLUTION/DROPS OPHTHALMIC 9993470 March 14, 2034 REDUCTION OF ELEVATED INTRAOCULAR PRESSURE

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Prostaglandin F2-alpha receptor GPCR AGONIST Ki 6.30 IUPHAR CHEMBL
Prostaglandin E2 receptor EP1 subtype GPCR Ki 5.76 PDSP
Prostaglandin E2 receptor EP3 subtype GPCR Ki 5.19 PDSP
Prostaglandin F2-alpha receptor GPCR Ki 7.01 CHEMBL

External reference:

IDSource
4020967 VUID
N0000148440 NUI
D00356 KEGG_DRUG
4020967 VANDF
C0090306 UMLSCUI
CHEBI:6384 CHEBI
CHEMBL1051 ChEMBL_ID
D000077338 MESH_DESCRIPTOR_UI
DB00654 DRUGBANK_ID
5311221 PUBCHEM_CID
6980 INN_ID
6Z5B6HVF6O UNII
153159 RXNORM
4959 MMSL
52442 MMSL
5860 MMSL
d04017 MMSL
006059 NDDF
108838001 SNOMEDCT_US
386926002 SNOMEDCT_US
C5888541 UMLSCUI
CHEMBL1050 ChEMBL_ID
41639-83-2 SECONDARY_CAS_RN
6441636 PUBCHEM_CID
EJ85341990 UNII
CHEBI:63925 CHEBI
6Z5B6HVF6O INXIGHT DRUGS
EJ85341990 INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Xalatan HUMAN PRESCRIPTION DRUG LABEL 1 0013-8303 SOLUTION 50 ug OPHTHALMIC NDA 25 sections
Latanoprost HUMAN PRESCRIPTION DRUG LABEL 1 21695-986 SOLUTION/ DROPS 50 ug OPHTHALMIC ANDA 26 sections
Latanoprost HUMAN PRESCRIPTION DRUG LABEL 1 24208-463 SOLUTION/ DROPS 50 ug OPHTHALMIC ANDA 24 sections
Latanoprost HUMAN PRESCRIPTION DRUG LABEL 1 24208-463 SOLUTION/ DROPS 50 ug OPHTHALMIC ANDA 24 sections
Latanoprost HUMAN PRESCRIPTION DRUG LABEL 1 25021-001 SOLUTION/ DROPS 50 ug OPHTHALMIC ANDA 27 sections
Latanoprost HUMAN PRESCRIPTION DRUG LABEL 1 42571-499 SOLUTION/ DROPS 50 ug OPHTHALMIC ANDA 24 sections
XELPROS HUMAN PRESCRIPTION DRUG LABEL 1 47335-317 SOLUTION/ DROPS 0.05 mg OPHTHALMIC NDA 24 sections
Latanoprost HUMAN PRESCRIPTION DRUG LABEL 1 50090-1920 SOLUTION/ DROPS 50 ug OPHTHALMIC ANDA 24 sections
Latanoprost HUMAN PRESCRIPTION DRUG LABEL 1 50090-7062 SOLUTION 50 ug OPHTHALMIC ANDA 24 sections
Latanoprost HUMAN PRESCRIPTION DRUG LABEL 1 54868-6254 SOLUTION/ DROPS 50 ug OPHTHALMIC ANDA 26 sections
LATANOPROST HUMAN PRESCRIPTION DRUG LABEL 1 55545-1010 SOLUTION 50 ug OPHTHALMIC ANDA 24 sections
XALATAN HUMAN PRESCRIPTION DRUG LABEL 1 58151-419 SOLUTION/ DROPS 50 ug OPHTHALMIC NDA 25 sections
Latanoprost HUMAN PRESCRIPTION DRUG LABEL 1 59762-0333 SOLUTION 50 ug OPHTHALMIC NDA authorized generic 25 sections
Latanoprost HUMAN PRESCRIPTION DRUG LABEL 1 61314-547 SOLUTION 50 ug OPHTHALMIC ANDA 24 sections
LATANOPROST HUMAN PRESCRIPTION DRUG LABEL 1 61919-112 SOLUTION/ DROPS 50 ug OPHTHALMIC ANDA 12 sections
LATANOPROST HUMAN PRESCRIPTION DRUG LABEL 1 64980-516 SOLUTION 50 ug OPHTHALMIC ANDA 22 sections
Latanoprost Human Prescription Drug Label 1 65862-872 SOLUTION/ DROPS 50 ug OPHTHALMIC ANDA 24 sections
LATANOPROST HUMAN PRESCRIPTION DRUG LABEL 1 68071-2376 SOLUTION/ DROPS 50 ug OPHTHALMIC ANDA 20 sections
Latanoprost HUMAN PRESCRIPTION DRUG LABEL 1 68071-3884 SOLUTION 50 ug OPHTHALMIC ANDA 24 sections
Latanoprost HUMAN PRESCRIPTION DRUG LABEL 1 68071-4612 SOLUTION/ DROPS 50 ug OPHTHALMIC ANDA 25 sections
Latanoprost HUMAN PRESCRIPTION DRUG LABEL 1 68071-4650 SOLUTION/ DROPS 50 ug OPHTHALMIC ANDA 25 sections
LATANOPROST HUMAN PRESCRIPTION DRUG LABEL 1 68071-4893 SOLUTION 50 ug OPHTHALMIC ANDA 24 sections
latanoprost Human Prescription Drug Label 1 68083-609 SOLUTION/ DROPS 50 ug OPHTHALMIC ANDA 24 sections
Xalatan HUMAN PRESCRIPTION DRUG LABEL 1 68258-8976 SOLUTION 50 ug OPHTHALMIC NDA 24 sections
latanoprost HUMAN PRESCRIPTION DRUG LABEL 1 68462-944 SOLUTION/ DROPS 50 ug OPHTHALMIC ANDA 24 sections
LATANOPROST HUMAN PRESCRIPTION DRUG LABEL 1 70069-421 SOLUTION/ DROPS 50 ug OPHTHALMIC ANDA 20 sections
Latanoprost PF HUMAN PRESCRIPTION DRUG LABEL 1 70261-515 SOLUTION/ DROPS 0.05 mg OPHTHALMIC unapproved drug other 2 sections
Tim-Lat -PF HUMAN PRESCRIPTION DRUG LABEL 2 70261-517 SOLUTION/ DROPS 0.05 mg OPHTHALMIC unapproved drug other 2 sections
Tim-Dor-Lat HUMAN PRESCRIPTION DRUG LABEL 3 70261-521 SOLUTION/ DROPS 0.05 mg OPHTHALMIC unapproved drug other 2 sections
Tim-Brim-Dor-Lat HUMAN PRESCRIPTION DRUG LABEL 4 70261-522 SOLUTION/ DROPS 0.05 mg OPHTHALMIC unapproved drug other 2 sections