aspartic acid Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1550 56-84-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • L-Aspartic acid
  • asparagic acid
  • aspartic acid
One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
  • Molecular weight: 133.10
  • Formula: C4H7NO4
  • CLOGP: -2.41
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 100.62
  • ALOGS: 0.03
  • ROTB: 3

Drug dosage:

None

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 643.97 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Foetal growth restriction 71.71 40.61 15 338 7159 53341554
Infantile apnoea 49.27 40.61 8 345 944 53347769
Selective eating disorder 43.51 40.61 8 345 1950 53346763

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:25512 neurotransmitters
CHEBI has role CHEBI:75771 Mus musculus metabolite
CHEBI has role CHEBI:76971 E.coli metabolites
CHEBI has role CHEBI:78675 essential metabolite

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypokalemia indication 43339004
Hypokalemia Prevention indication
Hyperkalemia contraindication 14140009
Complete atrioventricular block contraindication 27885002
Gastrointestinal ulcer contraindication 40845000
Congenital myotonia, autosomal dominant form contraindication 57938005
Acute nephropathy contraindication 58574008
Diarrhea contraindication 62315008
Kidney disease contraindication 90708001 DOID:557
Gastrointestinal obstruction contraindication 126765001
Gastroparesis contraindication 235675006
Chronic diarrhea contraindication 236071009
Hyporeninemic hypoaldosteronism contraindication 236464008
Familial hyperkalemic periodic paralysis contraindication 304737009 DOID:14451
Severe dehydration contraindication 450316000

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.45 acidic
pKa2 3.18 acidic
pKa3 10.47 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Calcium-binding mitochondrial carrier protein Aralar1 Transporter WOMBAT-PK
Aspartate aminotransferase, cytoplasmic Enzyme WOMBAT-PK
Aspartoacylase Enzyme WOMBAT-PK
Asparagine synthetase [glutamine-hydrolyzing] Enzyme WOMBAT-PK
Argininosuccinate synthase Enzyme WOMBAT-PK
Aminoacylase-1 Enzyme WOMBAT-PK
Aspartate aminotransferase, mitochondrial Enzyme WOMBAT-PK
Aspartate--tRNA ligase, cytoplasmic Enzyme WOMBAT-PK
Aspartyl/asparaginyl beta-hydroxylase Enzyme WOMBAT-PK
Excitatory amino acid transporter 1 Transporter IC50 5.03 CHEMBL
Excitatory amino acid transporter 2 Transporter IC50 4.50 CHEMBL
Excitatory amino acid transporter 3 Transporter IC50 4.71 CHEMBL
Calcium-binding mitochondrial carrier protein Aralar2 Transporter WOMBAT-PK
Glutamate NMDA receptor Ion channel IC50 5.79 CHEMBL
Excitatory amino acid transporter 4 Transporter IC50 4.96 CHEMBL
Glutamate transporter homolog Transporter Kd 9 CHEMBL
4-hydroxy-tetrahydrodipicolinate synthase Unclassified Ki 4.05 CHEMBL

External reference:

IDSource
4018680 VUID
N0000146991 NUI
D00013 KEGG_DRUG
4018680 VANDF
C0004015 UMLSCUI
CHEBI:22660 CHEBI
ASP PDB_CHEM_ID
CHEMBL274323 ChEMBL_ID
D001224 MESH_DESCRIPTOR_UI
DB00128 DRUGBANK_ID
3309 IUPHAR_LIGAND_ID
1570 INN_ID
30KYC7MIAI UNII
5960 PUBCHEM_CID
1169 RXNORM
NOCODE MMSL
000933 NDDF
44970006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
TrophAmine HUMAN PRESCRIPTION DRUG LABEL 20 0264-1933 SOLUTION 0.32 g INTRAVENOUS NDA 23 sections
Plenamine HUMAN PRESCRIPTION DRUG LABEL 17 0264-3200 SOLUTION 434 mg INTRAVENOUS ANDA 20 sections
Plenamine HUMAN PRESCRIPTION DRUG LABEL 17 0264-3205 SOLUTION 434 mg INTRAVENOUS ANDA 20 sections
Plenamine HUMAN PRESCRIPTION DRUG LABEL 17 0264-4500 SOLUTION 434 mg INTRAVENOUS ANDA 20 sections
TrophAmine HUMAN PRESCRIPTION DRUG LABEL 20 0264-9341 SOLUTION 0.32 g INTRAVENOUS NDA 23 sections
TrophAmine HUMAN PRESCRIPTION DRUG LABEL 20 0264-9361 SOLUTION 0.19 g INTRAVENOUS NDA 23 sections
ProSol HUMAN PRESCRIPTION DRUG LABEL 17 0338-0499 INJECTION, SOLUTION 600 mg INTRAVENOUS NDA 21 sections
Clinisol HUMAN PRESCRIPTION DRUG LABEL 17 0338-0502 INJECTION, SOLUTION 434 mg INTRAVENOUS ANDA 18 sections
Premasol - sulfite-free (Amino Acid) HUMAN PRESCRIPTION DRUG LABEL 19 0338-1130 INJECTION, SOLUTION 0.32 g INTRAVENOUS ANDA 15 sections
Premasol - sulfite-free (Amino Acid) HUMAN PRESCRIPTION DRUG LABEL 19 0338-1131 INJECTION, SOLUTION 0.19 g INTRAVENOUS ANDA 15 sections
Aminosyn-PF HUMAN PRESCRIPTION DRUG LABEL 18 0409-4178 INJECTION, SOLUTION 370 mg INTRAVENOUS NDA 14 sections
Aminosyn II HUMAN PRESCRIPTION DRUG LABEL 17 0409-7171 INJECTION, SOLUTION 1050 mg INTRAVENOUS NDA 19 sections
Aminosyn II HUMAN PRESCRIPTION DRUG LABEL 17 0409-7172 INJECTION, SOLUTION 700 mg INTRAVENOUS NDA 19 sections
Aminosyn-PF HUMAN PRESCRIPTION DRUG LABEL 18 0990-4178 INJECTION, SOLUTION 370 mg INTRAVENOUS NDA 13 sections
Aminosyn-PF HUMAN PRESCRIPTION DRUG LABEL 18 0990-4179 INJECTION, SOLUTION 527 mg INTRAVENOUS NDA 14 sections
Aminosyn II HUMAN PRESCRIPTION DRUG LABEL 17 0990-7171 INJECTION, SOLUTION 1050 mg INTRAVENOUS NDA 19 sections
Aminosyn II HUMAN PRESCRIPTION DRUG LABEL 17 0990-7172 INJECTION, SOLUTION 700 mg INTRAVENOUS NDA 19 sections
Kabiven HUMAN PRESCRIPTION DRUG LABEL 24 63323-712 INJECTION, EMULSION 99 mg INTRAVENOUS NDA 25 sections
Perikabiven HUMAN PRESCRIPTION DRUG LABEL 24 63323-714 INJECTION, EMULSION 71 mg INTRAVENOUS NDA 25 sections