lactose 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1535 63-42-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • anhydrous lactose
  • lactose
  • aletobiose
  • (+)-Lactose
  • dilactose
  • lactobiose
  • respitose
A disaccharide of GLUCOSE and GALACTOSE in human and cow milk. It is used in pharmacy for tablets, in medicine as a nutrient, and in industry.
  • Molecular weight: 342.30
  • Formula: C12H22O11
  • CLOGP: -4.40
  • LIPINSKI: 2
  • HAC: 11
  • HDO: 8
  • TPSA: 189.53
  • ALOGS: 0.23
  • ROTB: 4

Drug dosage:

None

ADMET properties:

PropertyValueReference
S (Water solubility) 195 mg/mL Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Bocci G, Oprea TI, Benet LZ

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Allergic reaction to excipient 125.53 26.74 19 1599 354 63487050
Drug hypersensitivity 70.28 26.74 60 1558 310627 63176777
Allergy to metals 52.85 26.74 10 1608 725 63486679
Iodine allergy 51.96 26.74 10 1608 794 63486610
Oesophagitis 51.81 26.74 18 1600 14990 63472414
Eye oedema 45.61 26.74 10 1608 1510 63485894
Rubber sensitivity 41.35 26.74 10 1608 2321 63485083
Angioedema 29.05 26.74 17 1601 47948 63439456

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Allergic reaction to excipient 130.33 23.53 19 1653 333 79742383
Drug hypersensitivity 48.45 23.53 44 1628 298872 79443844
Eye oedema 44.51 23.53 10 1662 2053 79740663
Oesophagitis 32.96 23.53 14 1658 24275 79718441
Angioedema 24.90 23.53 17 1655 76018 79666698

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D005421 Flavoring Agents
MeSH PA D005503 Food Additives
MeSH PA D013549 Sweetening Agents
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Lactose intolerance indication 267425008
Indigestion off-label use 162031009




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.33 acidic
pKa2 13.14 acidic
pKa3 13.68 acidic
pKa4 13.99 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Galectin-8 Unclassified Kd 4.21 CHEMBL
Galectin-9 Unclassified Kd 4.64 CHEMBL
Galectin-3 Unclassified Kd 4.03 CHEMBL

External reference:

IDSource
4018071 VUID
N0000023146 NUI
D00046 KEGG_DRUG
4017823 VANDF
4018071 VANDF
C0022949 UMLSCUI
CHEBI:36219 CHEBI
LBT PDB_CHEM_ID
CHEMBL417016 ChEMBL_ID
CHEMBL2106323 ChEMBL_ID
DB04465 DRUGBANK_ID
D007785 MESH_DESCRIPTOR_UI
6134 PUBCHEM_CID
1307662 RXNORM
NOCODE MMSL
002432 NDDF
423291009 SNOMEDCT_US
47703008 SNOMEDCT_US
3SY5LH9PMK UNII

Pharmaceutical products:

None