lactose 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1535 63-42-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • anhydrous lactose
  • lactose
  • aletobiose
  • (+)-Lactose
  • dilactose
  • lactobiose
  • respitose
A disaccharide of GLUCOSE and GALACTOSE in human and cow milk. It is used in pharmacy for tablets, in medicine as a nutrient, and in industry.
  • Molecular weight: 342.30
  • Formula: C12H22O11
  • CLOGP: -4.40
  • LIPINSKI: 2
  • HAC: 11
  • HDO: 8
  • TPSA: 189.53
  • ALOGS: 0.23
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Allergic reaction to excipient 127.42 25.43 19 1483 271 50603351
Drug hypersensitivity 71.44 25.43 59 1443 250951 50352671
Allergy to metals 54.84 25.43 10 1492 507 50603115
Iodine allergy 51.81 25.43 10 1492 691 50602931
Oesophagitis 51.15 25.43 18 1484 13365 50590257
Eye oedema 45.32 25.43 10 1492 1333 50602289
Rubber sensitivity 42.36 25.43 10 1492 1799 50601823
Angioedema 30.47 25.43 17 1485 37659 50565963
Food allergy 27.51 25.43 10 1492 8127 50595495

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Dehydration 25.88 25.83 25 966 114723 29458813

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Allergic reaction to excipient 134.36 24.53 19 1510 233 64496970
Drug hypersensitivity 50.46 24.53 43 1486 237772 64259431
Eye oedema 44.79 24.53 10 1519 1763 64495440
Oesophagitis 32.87 24.53 14 1515 21616 64475587
Angioedema 26.21 24.53 17 1512 61804 64435399

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D005421 Flavoring Agents
MeSH PA D005503 Food Additives
MeSH PA D013549 Sweetening Agents
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Lactose intolerance indication 267425008
Indigestion off-label use 162031009




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.33 acidic
pKa2 13.14 acidic
pKa3 13.68 acidic
pKa4 13.99 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Galectin-8 Unclassified Kd 4.21 CHEMBL
Galectin-9 Unclassified Kd 4.64 CHEMBL
Galectin-3 Unclassified Kd 4.03 CHEMBL

External reference:

IDSource
4018071 VUID
N0000023146 NUI
D00046 KEGG_DRUG
4017823 VANDF
4018071 VANDF
C0022949 UMLSCUI
CHEBI:36219 CHEBI
LBT PDB_CHEM_ID
CHEMBL417016 ChEMBL_ID
DB04465 DRUGBANK_ID
D007785 MESH_DESCRIPTOR_UI
6134 PUBCHEM_CID
3SY5LH9PMK UNII
1307662 RXNORM
NOCODE MMSL
002432 NDDF
423291009 SNOMEDCT_US
47703008 SNOMEDCT_US

Pharmaceutical products:

None