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lactose 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1535 | 63-42-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A disaccharide of GLUCOSE and GALACTOSE in human and cow milk. It is used in pharmacy for tablets, in medicine as a nutrient, and in industry.
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 195 mg/mL | Bocci G, Oprea TI, Benet LZ |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Bocci G, Oprea TI, Benet LZ |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | -1.297 | Moderate | 0.77 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 2.612 | Moderate | 0.77 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 0.435 | 10^-6 cm/s | Moderate | 0.77 |
| dh-clint | Dog hepatocyte intrinsic clearance | 1.175 | uL/min/10^6 cells | Moderate | 0.77 |
| dppb | Dog plasma protein binding (% unbound) | 84.510 | % | Moderate | 0.77 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 88.140 | % | Moderate | 0.77 |
| herg | hERG pIC50 | 3.906 | pIC50 | Moderate | 0.77 |
| hh-clint | Human hepatocyte intrinsic clearance | 0.776 | uL/min/10^6 cells | Moderate | 0.77 |
| hlm-clint | Human liver microsomal intrinsic clearance | 3.475 | uL/min/mg protein | Moderate | 0.77 |
| hppb | Human plasma protein binding (% unbound) | 77.660 | % | Moderate | 0.77 |
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 0.570 | Moderate | 0.77 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 0.714 | Moderate | 0.77 | |
| mppb | Mouse plasma protein binding (% unbound) | 89.640 | Moderate | 0.77 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 0.624 | Moderate | 0.77 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 92.580 | % | Moderate | 0.77 |
| rh-clint | Rat hepatocyte intrinsic clearance | 3.020 | uL/min/10^6 cells | Moderate | 0.77 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 94.270 | % | Moderate | 0.77 |
| rppb | Rat plasma protein binding (% unbound) | 86.700 | % | Moderate | 0.77 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 907.821 | uM | Moderate | 0.77 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Allergic reaction to excipient | 132.79 | 32.21 | 19 | 732 | 769 | 90626927 |
| Drug hypersensitivity | 110.91 | 32.21 | 60 | 691 | 463549 | 90164147 |
| Iodine allergy | 62.24 | 32.21 | 10 | 741 | 876 | 90626820 |
| Allergy to metals | 60.64 | 32.21 | 10 | 741 | 1030 | 90626666 |
| Eye oedema | 54.35 | 32.21 | 10 | 741 | 1942 | 90625754 |
| Rubber sensitivity | 50.62 | 32.21 | 10 | 741 | 2827 | 90624869 |
| Angioedema | 42.44 | 32.21 | 17 | 734 | 64859 | 90562837 |
| Swelling face | 35.50 | 32.21 | 16 | 735 | 81336 | 90546360 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Allergic reaction to excipient | 136.80 | 32.87 | 19 | 713 | 780 | 110587787 |
| Drug hypersensitivity | 75.53 | 32.87 | 43 | 689 | 454047 | 110134520 |
| Eye oedema | 53.88 | 32.87 | 10 | 722 | 2552 | 110586015 |
| Angioedema | 39.27 | 32.87 | 17 | 715 | 98483 | 110490084 |
| Swelling face | 33.76 | 32.87 | 15 | 717 | 92306 | 110496261 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D005421 | Flavoring Agents |
| MeSH PA | D005503 | Food Additives |
| MeSH PA | D013549 | Sweetening Agents |
| CHEBI has role | CHEBI:77746 | human metabolite |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Lactose intolerance | indication | 267425008 | |
| Indigestion | off-label use | 162031009 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.33 | acidic |
| pKa2 | 13.14 | acidic |
| pKa3 | 13.68 | acidic |
| pKa4 | 13.99 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Galectin-8 | Secreted | Kd | 4.21 | CHEMBL | |||||
| Galectin-9 | Secreted | Kd | 4.64 | CHEMBL | |||||
| Galectin-3 | Secreted | Kd | 4.03 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4018071 | VUID |
| N0000023146 | NUI |
| D00046 | KEGG_DRUG |
| 4017823 | VANDF |
| 4018071 | VANDF |
| C0022949 | UMLSCUI |
| CHEBI:36218 | CHEBI |
| LBT | PDB_CHEM_ID |
| CHEMBL5314358 | ChEMBL_ID |
| CHEMBL5498481 | ChEMBL_ID |
| DB04465 | DRUGBANK_ID |
| D007785 | MESH_DESCRIPTOR_UI |
| 6134 | PUBCHEM_CID |
| 1307662 | RXNORM |
| NOCODE | MMSL |
| 002432 | NDDF |
| 423291009 | SNOMEDCT_US |
| 47703008 | SNOMEDCT_US |
| 3SY5LH9PMK | UNII |
| 3SY5LH9PMK | INXIGHT DRUGS |
Pharmaceutical products:
None