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2022 Update-Veterinary Drugs & Uses
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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Structure 🔎
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L1000
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
lacidipine 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
calcium channel blockers, nifedipine derivatives
1532
103890-78-4
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
lacidipine
lacipil
lacirex
GR-43659X
motens
Molecular weight: 455.55
Formula: C26H33NO6
CLOGP: 5.93
LIPINSKI: 1
HAC: 7
HDO: 1
TPSA: 90.93
ALOGS: -5.31
ROTB: 11
Drug dosage:
Dose
Unit
Route
4
mg
O
ADMET properties:
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Property
Value
Reference
BA (Bioavailability)
18 %
Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
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Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Procalcitonin abnormal
64.18
39.47
11
1079
371
34955470
Encephalomalacia
55.29
39.47
11
1079
847
34954994
PO2 decreased
48.59
39.47
11
1079
1570
34954271
Acquired macroglossia
47.95
39.47
6
1084
18
34955823
PCO2 decreased
47.32
39.47
11
1079
1765
34954076
Device related sepsis
41.26
39.47
11
1079
3082
34952759
Lymphocyte count increased
40.34
39.47
11
1079
3354
34952487
Showing 1 to 7 of 7 entries
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1
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FDA Adverse Event Reporting System (Geriatric)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Procalcitonin abnormal
67.53
32.46
11
1780
379
79742218
Encephalomalacia
54.82
32.46
11
1780
1230
79741367
Drug interaction
47.21
32.46
52
1739
415131
79327466
PO2 decreased
45.29
32.46
11
1780
2952
79739645
PCO2 decreased
44.60
32.46
11
1780
3143
79739454
International normalised ratio increased
44.05
32.46
26
1765
84695
79657902
Lymphocyte count increased
42.18
32.46
12
1779
5920
79736677
Device related sepsis
37.17
32.46
11
1780
6229
79736368
Acquired macroglossia
36.49
32.46
6
1785
219
79742378
Scrotal oedema
35.37
32.46
8
1783
1577
79741020
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FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
C08CA09
CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
MeSH PA
D000959
Antihypertensive Agents
MeSH PA
D002121
Calcium Channel Blockers
MeSH PA
D000077264
Calcium-Regulating Hormones and Agents
MeSH PA
D002317
Cardiovascular Agents
MeSH PA
D049990
Membrane Transport Modulators
Showing 1 to 6 of 6 entries
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
2.23
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Voltage-gated L-type calcium channel
Ion channel
Q01668
Q13936
CAC1D_HUMAN
CAC1C_HUMAN
BLOCKER
SCIENTIFIC LITERATURE
SCIENTIFIC LITERATURE
Sodium-dependent noradrenaline transporter
Transporter
P23975
SC6A2_HUMAN
Ki
5.25
DRUG MATRIX
D(3) dopamine receptor
GPCR
P35462
DRD3_HUMAN
Ki
5.68
DRUG MATRIX
Adenosine receptor A3
GPCR
P0DMS8
AA3R_HUMAN
Ki
5.64
DRUG MATRIX
Cytochrome P450 3A4
Enzyme
P08684
CP3A4_HUMAN
IC50
6.05
DRUG MATRIX
Cytochrome P450 2C19
Enzyme
P33261
CP2CJ_HUMAN
IC50
5.70
DRUG MATRIX
Thromboxane-A synthase
Enzyme
P24557
THAS_HUMAN
IC50
5.77
DRUG MATRIX
Cytochrome P450 2C9
Enzyme
P11712
CP2C9_HUMAN
IC50
5.70
DRUG MATRIX
Androgen receptor
Transcription factor
ANDR_RAT
Ki
5.58
DRUG MATRIX
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External reference:
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entries
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ID
Source
004453
NDDF
11740
IUPHAR_LIGAND_ID
260080034N
UNII
28382
RXNORM
319299000
SNOMEDCT_US
395764001
SNOMEDCT_US
4025250
VUID
4025250
VANDF
5311217
PUBCHEM_CID
6093
INN_ID
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Pharmaceutical products:
None
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lacidipine