ketoprofen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
anti-inflammatory agents, ibuprofen derivatives	1528	22071-15-4

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: RP 19583 RP-19583 ketoprofen ketoprofene ketoprophen	An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It is used in the treatment of rheumatoid arthritis and osteoarthritis. Molecular weight: 254.29 Formula: C16H14O3 CLOGP: 2.76 LIPINSKI: 0 HAC: 3 HDO: 1 TPSA: 54.37 ALOGS: -4.08 ROTB: 4 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

RP 19583
RP-19583
ketoprofen
ketoprofene
ketoprophen

An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It is used in the treatment of rheumatoid arthritis and osteoarthritis.

Molecular weight: 254.29
Formula: C16H14O3
CLOGP: 2.76
LIPINSKI: 0
HAC: 3
HDO: 1
TPSA: 54.37
ALOGS: -4.08
ROTB: 4

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.15	g	O
0.15	g	P
0.15	g	R

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.01 mg/mL	Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine)	0.50 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	19.66 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	90 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	0.13 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	1.60 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.01 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	2.10 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Jan. 9, 1986	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Temperature regulation disorder	572.61	14.20	168	21355	5964	63461535
Food allergy	473.97	14.20	169	21354	11232	63456267
Coeliac disease	447.59	14.20	167	21356	12630	63454869
Immunodeficiency	392.73	14.20	173	21350	20081	63447418
Bursitis	293.94	14.20	173	21350	36868	63430631
Rash erythematous	289.54	14.20	180	21343	42330	63425169
Fluid retention	214.73	14.20	171	21352	59515	63407984
Erythema	191.05	14.20	265	21258	175486	63292013
Upper respiratory tract infection	184.49	14.20	180	21343	81867	63385632
Hyperhidrosis	171.97	14.20	197	21326	107639	63359860
Asthma	167.34	14.20	211	21312	127350	63340149
Acute generalised exanthematous pustulosis	144.38	14.20	72	21451	11027	63456472
Acute kidney injury	137.11	14.20	286	21237	263129	63204370
Constipation	126.20	14.20	252	21271	224691	63242808
Overdose	99.55	14.20	156	21367	114922	63352577
Rheumatoid arthritis	96.95	14.20	244	21279	253575	63213924
Hepatocellular injury	91.09	14.20	75	21448	27306	63440193
Pulmonary pain	81.39	14.20	34	21489	3456	63464043
Back pain	76.97	14.20	230	21293	263915	63203584
Goitre	75.55	14.20	38	21485	5923	63461576
Hepatic enzyme increased	71.50	14.20	189	21334	202139	63265360
Cholestasis	70.64	14.20	67	21456	29367	63438132
Angioedema	70.30	14.20	84	21439	47881	63419618
Hepatic cytolysis	61.53	14.20	47	21476	15360	63452139
Face oedema	58.27	14.20	51	21472	20161	63447338
Intentional product misuse	54.60	14.20	84	21439	60833	63406666
Suicide attempt	54.60	14.20	84	21439	60834	63406665
Amyloid arthropathy	54.59	14.20	16	21507	564	63466935
Foetal death	54.03	14.20	38	21485	10942	63456557
Drug hypersensitivity	53.76	14.20	228	21295	310459	63157040
Alopecia	53.13	14.20	24	21499	337512	63129987
Lactic acidosis	49.56	14.20	63	21460	38224	63429275
Hypersensitivity	48.48	14.20	212	21311	292473	63175026
Drug abuse	46.37	14.20	86	21437	72432	63395067
Prescribed overdose	45.48	14.20	57	21466	34096	63433403
Peripheral nerve injury	44.92	14.20	13	21510	438	63467061
Allergy test negative	44.83	14.20	11	21512	193	63467306
Coma	44.54	14.20	79	21444	64285	63403214
Poisoning deliberate	44.30	14.20	34	21489	11184	63456315
Systemic lupus erythematosus	43.35	14.20	9	21514	208909	63258590
Spinal epidural haemorrhage	40.42	14.20	9	21514	101	63467398
Lip and/or oral cavity cancer	39.91	14.20	14	21509	884	63466615
Hepatic adenoma	39.17	14.20	11	21512	332	63467167
Drug reaction with eosinophilia and systemic symptoms	36.60	14.20	51	21472	33785	63433714
Hepatic function abnormal	35.81	14.20	53	21470	37089	63430410
Synovitis	34.97	14.20	10	21513	186908	63280591
Therapeutic product effect decreased	34.94	14.20	11	21512	193176	63274323
Hand deformity	34.92	14.20	6	21517	159451	63308048
Wound	33.93	14.20	7	21516	163256	63304243
Completed suicide	32.98	14.20	5	21518	145668	63321831
Aspirin-exacerbated respiratory disease	32.44	14.20	12	21511	883	63466616
Death	32.39	14.20	48	21475	374333	63093166
Anaphylactic shock	32.36	14.20	40	21483	23593	63443906
Type I hypersensitivity	32.21	14.20	17	21506	2925	63464574
Toxic skin eruption	32.19	14.20	30	21493	12855	63454644
Toxic epidermal necrolysis	31.70	14.20	41	21482	25293	63442206
Ankylosing spondylitis	31.34	14.20	27	21496	10447	63457052
Burning mouth syndrome	30.73	14.20	10	21513	501	63466998
Femoral artery dissection	30.28	14.20	6	21517	36	63467463
Gastritis erosive	29.94	14.20	21	21502	6018	63461481
Drug interaction	29.21	14.20	154	21369	228977	63238522
Sinoatrial block	28.89	14.20	11	21512	877	63466622
Epidural haemorrhage	28.68	14.20	7	21516	120	63467379
Sinusitis	28.67	14.20	21	21502	226632	63240867
Intentional overdose	27.91	14.20	71	21452	74081	63393418
Headache	27.76	14.20	332	21191	632909	62834590
Melaena	27.37	14.20	42	21481	30323	63437176
Pneumoperitoneum	26.89	14.20	12	21511	1431	63466068
Fine motor skill dysfunction	26.81	14.20	18	21505	4807	63462692
Pericarditis	26.60	14.20	6	21517	131573	63335926
Tubulointerstitial nephritis	26.15	14.20	33	21490	19870	63447629
Weight increased	26.07	14.20	30	21493	260762	63206737
Glomerulonephropathy	25.65	14.20	6	21517	85	63467414
Psoriasis	24.56	14.20	75	21448	86882	63380617
Nasal disorder	24.34	14.20	14	21509	2850	63464649
Pneumococcal sepsis	23.96	14.20	9	21514	691	63466808
Thrombocytopenia	23.84	14.20	108	21415	151049	63316450
Vanishing bile duct syndrome	23.57	14.20	9	21514	723	63466776
Upper respiratory tract inflammation	23.24	14.20	13	21510	2510	63464989
Epidural analgesia	23.16	14.20	5	21518	48	63467451
Mobility decreased	21.71	14.20	7	21516	121152	63346347
Septic shock	21.24	14.20	60	21463	66569	63400930
Foetal heart rate abnormal	21.12	14.20	8	21515	629	63466870
Nephrolithiasis	21.06	14.20	45	21478	41939	63425560
Hepatitis acute	20.44	14.20	20	21503	9100	63458399
Duplicate therapy error	20.10	14.20	5	21518	93	63467406
Impaired healing	20.09	14.20	5	21518	102537	63364962
Miosis	20.08	14.20	18	21505	7335	63460164
Atypical haemolytic uraemic syndrome	20.00	14.20	8	21515	727	63466772
Thyroid cancer	19.98	14.20	16	21507	5595	63461904
Gastric ulcer	19.93	14.20	32	21491	24005	63443494
Upper gastrointestinal haemorrhage	19.77	14.20	28	21495	18824	63448675
Gastroenteropancreatic neuroendocrine tumour disease	19.29	14.20	4	21519	31	63467468
Pancreatitis necrotising	19.05	14.20	10	21513	1702	63465797
Inflammation	18.77	14.20	66	21457	82207	63385292
Mixed anxiety and depressive disorder	18.53	14.20	6	21517	296	63467203
Skin turgor decreased	18.38	14.20	7	21516	558	63466941
Pancreatitis acute	18.34	14.20	33	21490	27133	63440366
Oedematous pancreatitis	18.19	14.20	7	21516	574	63466925
Contraindicated product administered	18.06	14.20	131	21392	217517	63249982
Hypertransaminasaemia	17.70	14.20	16	21507	6593	63460906
Linear IgA disease	17.65	14.20	9	21514	1442	63466057
Cell death	17.65	14.20	11	21512	2590	63464909
Vascular purpura	17.50	14.20	9	21514	1469	63466030
Reversible cerebral vasoconstriction syndrome	17.43	14.20	11	21512	2647	63464852
Intentional product use issue	17.29	14.20	11	21512	127881	63339618
Product dispensing issue	17.18	14.20	5	21518	172	63467327
Enteritis infectious	17.03	14.20	10	21513	2114	63465385
Abdominal discomfort	17.03	14.20	54	21469	320831	63146668
Osteomyelitis	16.80	14.20	31	21492	25989	63441510
Gastrointestinal disorder	16.79	14.20	12	21511	131227	63336272
Azotaemia	16.46	14.20	13	21510	4458	63463041
Social anxiety disorder	16.44	14.20	6	21517	425	63467074
Maternal exposure during pregnancy	16.42	14.20	31	21492	220031	63247468
Pyelonephritis acute	16.03	14.20	13	21510	4628	63462871
Disease progression	16.00	14.20	11	21512	122747	63344752
Ill-defined disorder	15.99	14.20	4	21519	81751	63385748
Anticholinergic syndrome	15.97	14.20	10	21513	2372	63465127
Duodenal ulcer perforation	15.69	14.20	5	21518	87204	63380295
Inflammatory bowel disease	15.60	14.20	12	21511	3961	63463538
Helicobacter infection	15.53	14.20	6	21517	92779	63374720
Adverse drug reaction	15.39	14.20	4	21519	79710	63387789
Gastric ulcer haemorrhage	15.39	14.20	13	21510	4895	63462604
Pyelonephritis	15.20	14.20	24	21499	17754	63449745
Blister	15.18	14.20	13	21510	129801	63337698
Aortic aneurysm rupture	15.06	14.20	6	21517	540	63466959
COVID-19	14.92	14.20	10	21513	113093	63354406
Spinal compression fracture	14.66	14.20	21	21502	14262	63453237
Muscle spasms	14.49	14.20	19	21504	156131	63311368
Anxiety	14.25	14.20	33	21490	217508	63249991

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Angioedema	114.21	14.22	98	11927	37276	34907630
Acute kidney injury	112.25	14.22	291	11734	304697	34640209
Anaphylactic shock	77.39	14.22	55	11970	15886	34929020
Radiation inflammation	63.58	14.22	20	12005	885	34944021
Acute generalised exanthematous pustulosis	62.19	14.22	35	11990	6741	34938165
Pulmonary pain	57.65	14.22	20	12005	1204	34943702
Allergy test negative	55.07	14.22	12	12013	119	34944787
Hyperaesthesia	53.89	14.22	28	11997	4602	34940304
Vascular purpura	53.89	14.22	21	12004	1757	34943149
Drug interaction	53.64	14.22	185	11840	225761	34719145
Death	53.26	14.22	36	11989	398013	34546893
Suicide attempt	50.94	14.22	65	11960	39051	34905855
Cholestasis	50.51	14.22	54	11971	26894	34918012
Lactic acidosis	48.82	14.22	60	11965	34712	34910194
Pancreatitis acute	45.18	14.22	52	11973	28089	34916817
Erythema	43.52	14.22	95	11930	88685	34856221
Polyneuropathy in malignant disease	42.68	14.22	11	12014	234	34944672
Hepatocellular injury	42.49	14.22	45	11980	22166	34922740
Gastric ulcer	41.69	14.22	38	11987	15612	34929294
Hepatitis cholestatic	37.59	14.22	27	11998	7920	34936986
Poisoning deliberate	35.62	14.22	26	11999	7818	34937088
Lung neoplasm malignant	34.62	14.22	36	11989	17359	34927547
Type I hypersensitivity	34.27	14.22	14	12011	1325	34943581
Drug level increased	34.07	14.22	40	11985	22056	34922850
Myoclonic epilepsy	32.73	14.22	13	12012	1144	34943762
Melaena	31.47	14.22	49	11976	35331	34909575
Coma	30.95	14.22	56	11969	45622	34899284
Enterocolitis	30.68	14.22	24	12001	8002	34936904
Eyelid oedema	30.36	14.22	20	12005	5104	34939802
Severe invasive streptococcal infection	29.78	14.22	6	12019	39	34944867
Mixed liver injury	29.55	14.22	16	12009	2857	34942049
Anorgasmia	29.11	14.22	11	12014	846	34944060
Palatal oedema	29.04	14.22	11	12014	852	34944054
Intentional overdose	27.65	14.22	52	11973	43622	34901284
Vitello-intestinal duct remnant	27.06	14.22	7	12018	151	34944755
Fatigue	26.48	14.22	55	11970	370598	34574308
Tongue oedema	26.20	14.22	15	12010	2982	34941924
Fusobacterium infection	26.05	14.22	6	12019	78	34944828
Blood lactic acid	25.79	14.22	8	12017	338	34944568
Laryngeal discomfort	25.06	14.22	7	12018	204	34944702
Rash pustular	24.72	14.22	18	12007	5390	34939516
Allodynia	22.33	14.22	9	12016	822	34944084
Diarrhoea infectious	21.51	14.22	8	12017	589	34944317
Schizophrenia	21.06	14.22	20	12005	8646	34936260
Overdose	21.02	14.22	74	11951	90985	34853921
Renal vasculitis	20.94	14.22	6	12019	192	34944714
Dermatitis bullous	20.80	14.22	18	12007	6904	34938002
Rash maculo-papular	20.70	14.22	36	11989	28415	34916491
Necrotising myositis	20.44	14.22	8	12017	677	34944229
Dyschezia	20.30	14.22	10	12015	1468	34943438
Eosinophilia	20.16	14.22	34	11991	26188	34918718
Metastases to lung	19.83	14.22	20	12005	9300	34935606
Inflammation	19.55	14.22	35	11990	28260	34916646
Anaemia	19.43	14.22	142	11883	233193	34711713
Vomiting	19.11	14.22	148	11877	247473	34697433
Metastases to bone	19.00	14.22	22	12003	11948	34932958
Liver injury	18.22	14.22	24	12001	14854	34930052
Gastric ulcer haemorrhage	18.04	14.22	15	12010	5451	34939455
Altered state of consciousness	18.02	14.22	30	11995	22863	34922043
Meningoencephalitis bacterial	17.89	14.22	5	12020	146	34944760
Hepatic function abnormal	17.89	14.22	44	11981	44319	34900587
Pruritus	17.81	14.22	96	11929	141885	34803021
Prothrombin time shortened	17.46	14.22	9	12016	1455	34943451
Hyperleukocytosis	17.45	14.22	10	12015	1992	34942914
Anterograde amnesia	17.10	14.22	5	12020	172	34944734
Off label use	16.70	14.22	81	11944	419443	34525463
Epilepsy congenital	16.10	14.22	3	12022	12	34944894
Miosis	15.94	14.22	18	12007	9517	34935389
Brain empyema	15.91	14.22	3	12022	13	34944893
Rhinitis allergic	15.90	14.22	11	12014	3039	34941867
Knee arthroplasty	15.89	14.22	16	12009	7428	34937478
Completed suicide	15.78	14.22	7	12018	98161	34846745
Genital pain	15.75	14.22	6	12019	472	34944434
Arthropathy	15.75	14.22	31	11994	26876	34918030
Hepatic cytolysis	15.65	14.22	22	12003	14474	34930432
Quality of life decreased	15.37	14.22	12	12013	3989	34940917
Anaphylactic reaction	15.16	14.22	34	11991	32267	34912639
Intentional product misuse	15.07	14.22	42	11983	45569	34899337
Dermatofibrosarcoma protuberans	14.96	14.22	3	12022	19	34944887
Toxic skin eruption	14.93	14.22	19	12006	11366	34933540
Hyperkalaemia	14.82	14.22	55	11970	69334	34875572
Pathological fracture	14.39	14.22	12	12013	4379	34940527

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Temperature regulation disorder	530.07	12.45	161	30329	5692	79708206
Food allergy	436.64	12.45	162	30328	10662	79703236
Coeliac disease	425.52	12.45	161	30329	11190	79702708
Immunodeficiency	345.57	12.45	168	30322	21600	79692298
Bursitis	259.63	12.45	165	30325	35679	79678219
Rash erythematous	226.46	12.45	183	30307	57586	79656312
Erythema	219.08	12.45	342	30148	222948	79490950
Acute kidney injury	217.12	12.45	556	29934	518848	79195050
Acute generalised exanthematous pustulosis	184.06	12.45	102	30388	17152	79696746
Fluid retention	173.64	12.45	171	30319	69638	79644260
Angioedema	168.55	12.45	175	30315	75860	79638038
Hyperhidrosis	145.57	12.45	230	30260	151262	79562636
Upper respiratory tract infection	142.55	12.45	175	30315	90993	79622905
Pulmonary pain	134.18	12.45	54	30436	4419	79709479
Asthma	131.01	12.45	206	30284	134889	79579009
Hepatocellular injury	122.83	12.45	119	30371	47474	79666424
Constipation	118.84	12.45	304	30186	282746	79431152
Cholestasis	108.43	12.45	116	30374	51993	79661905
Anaphylactic shock	98.55	12.45	93	30397	35903	79677995
Allergy test negative	96.59	12.45	23	30467	311	79713587
Overdose	94.60	12.45	214	30276	183992	79529906
Lactic acidosis	89.49	12.45	122	30368	70237	79643661
Rheumatoid arthritis	86.47	12.45	223	30267	208247	79505651
Suicide attempt	82.48	12.45	128	30362	82804	79631094
Death	72.54	12.45	66	30424	566448	79147450
Poisoning deliberate	70.26	12.45	58	30432	18770	79695128
Drug interaction	69.99	12.45	329	30161	414854	79299044
Hepatic enzyme increased	67.28	12.45	187	30303	182423	79531475
Coma	65.66	12.45	129	30361	100520	79613378
Vascular purpura	64.94	12.45	29	30461	3069	79710829
Back pain	62.60	12.45	256	30234	303924	79409974
Radiation inflammation	61.49	12.45	20	30470	885	79713013
Hepatic cytolysis	61.03	12.45	63	30427	27088	79686810
Intentional product misuse	60.90	12.45	121	30369	95044	79618854
Completed suicide	59.49	12.45	11	30479	245756	79468142
Hypersensitivity	57.38	12.45	225	30265	262014	79451884
Pancreatitis acute	57.09	12.45	82	30408	49522	79664376
Face oedema	55.65	12.45	61	30429	28075	79685823
Drug hypersensitivity	54.86	12.45	243	30247	298673	79415225
Gastric ulcer	52.80	12.45	65	30425	33840	79680058
Amyloid arthropathy	52.69	12.45	16	30474	564	79713334
Foetal death	50.79	12.45	34	30456	8010	79705888
Type I hypersensitivity	49.65	12.45	27	30463	4371	79709527
Drug level increased	46.29	12.45	66	30424	39585	79674313
Hepatitis cholestatic	46.19	12.45	40	30450	13812	79700086
Melaena	43.33	12.45	81	30409	60809	79653089
Enterocolitis	42.62	12.45	39	30451	14473	79699425
Eyelid oedema	40.62	12.45	37	30453	13650	79700248
Polyneuropathy in malignant disease	39.76	12.45	11	30479	277	79713621
Toxic skin eruption	38.42	12.45	45	30445	22248	79691650
Hyperaesthesia	38.16	12.45	34	30456	12188	79701710
Hepatic adenoma	37.95	12.45	11	30479	329	79713569
Aspirin-exacerbated respiratory disease	37.69	12.45	15	30475	1192	79712706
Peripheral nerve injury	37.50	12.45	13	30477	701	79713197
Drug reaction with eosinophilia and systemic symptoms	36.74	12.45	78	30412	64166	79649732
Hepatic function abnormal	36.43	12.45	84	30406	73023	79640875
Ankylosing spondylitis	36.23	12.45	33	30457	12172	79701726
Weight increased	35.80	12.45	32	30458	277354	79436544
Prescribed overdose	35.60	12.45	57	30433	37826	79676072
Lip and/or oral cavity cancer	35.34	12.45	14	30476	1099	79712799
Severe invasive streptococcal infection	34.34	12.45	7	30483	43	79713855
Intentional overdose	32.76	12.45	102	30388	105858	79608040
Contraindicated product administered	31.88	12.45	132	30358	157406	79556492
Laryngeal discomfort	31.80	12.45	11	30479	589	79713309
Goitre	31.62	12.45	22	30468	5517	79708381
Spinal epidural haemorrhage	31.35	12.45	8	30482	146	79713752
Tubulointerstitial nephritis	31.20	12.45	54	30436	38181	79675717
Sinusitis	31.17	12.45	18	30472	195483	79518415
Synovitis	30.16	12.45	10	30480	150724	79563174
Miosis	29.10	12.45	33	30457	15756	79698142
Burning mouth syndrome	28.78	12.45	10	30480	543	79713355
Femoral artery dissection	28.40	12.45	6	30484	45	79713853
Drug abuse	28.10	12.45	130	30360	162561	79551337
Gastric ulcer haemorrhage	27.96	12.45	25	30465	9002	79704896
Gastritis erosive	27.74	12.45	27	30463	10820	79703078
Altered state of consciousness	27.15	12.45	55	30435	43767	79670131
Glossodynia	26.37	12.45	4	30486	103333	79610565
Therapeutic product effect decreased	26.25	12.45	15	30475	163848	79550050
Vitello-intestinal duct remnant	25.99	12.45	7	30483	159	79713739
Anaphylactic reaction	25.31	12.45	80	30410	83663	79630235
Lung neoplasm malignant	25.00	12.45	41	30449	27751	79686147
Dermatitis bullous	24.95	12.45	29	30461	14216	79699682
Hepatitis acute	24.52	12.45	30	30460	15512	79698386
Rash maculo-papular	24.25	12.45	61	30429	56017	79657881
Foetal heart rate abnormal	24.13	12.45	8	30482	376	79713522
Anorgasmia	23.94	12.45	11	30479	1243	79712655
Epidural haemorrhage	23.85	12.45	7	30483	219	79713679
Fall	23.65	12.45	101	30389	487528	79226370
Dermatofibrosarcoma protuberans	23.60	12.45	5	30485	38	79713860
Fusobacterium infection	23.34	12.45	6	30484	113	79713785
Blood lactic acid	22.67	12.45	8	30482	455	79713443
Systemic lupus erythematosus	22.60	12.45	9	30481	121140	79592758
Palatal oedema	22.56	12.45	11	30479	1420	79712478
Hand deformity	22.41	12.45	6	30484	103913	79609985
Epidural analgesia	22.38	12.45	5	30485	50	79713848
Pneumoperitoneum	21.72	12.45	14	30476	3094	79710804
Mixed liver injury	21.54	12.45	20	30470	7558	79706340
Cerebrovascular accident	21.14	12.45	17	30473	155275	79558623
Wound	21.07	12.45	9	30481	116170	79597728
Pericarditis	20.70	12.45	7	30483	104229	79609669
Upper respiratory tract inflammation	20.66	12.45	15	30475	4020	79709878
Lip oedema	20.58	12.45	18	30472	6298	79707600
Intentional product use issue	20.28	12.45	17	30473	152095	79561803
Sinoatrial block	20.15	12.45	10	30480	1341	79712557
Dyschezia	19.76	12.45	13	30477	2975	79710923
Dizziness	19.33	12.45	120	30370	526321	79187577
Inflammation	19.30	12.45	79	30411	93674	79620224
Alopecia	19.25	12.45	37	30453	231318	79482580
Meningoencephalitis bacterial	19.17	12.45	6	30484	234	79713664
Fine motor skill dysfunction	18.94	12.45	16	30474	5341	79708557
Lethargy	18.89	12.45	4	30486	81288	79632610
Hyperleukocytosis	18.84	12.45	12	30478	2598	79711300
Thyroid cancer	18.35	12.45	16	30474	5572	79708326
Anxiety	17.97	12.45	43	30447	248469	79465429
Mediastinitis	17.83	12.45	8	30482	856	79713042
Osteomyelitis	17.75	12.45	39	30451	32826	79681072
Toxic epidermal necrolysis	17.73	12.45	47	30443	44534	79669364
Gastroenteropancreatic neuroendocrine tumour disease	17.56	12.45	4	30486	44	79713854
Glomerulonephropathy	17.50	12.45	6	30484	313	79713585
Urticaria	17.47	12.45	126	30364	185075	79528823
Photosensitivity reaction	17.45	12.45	30	30460	21097	79692801
Psoriasis	17.28	12.45	74	30416	89513	79624385
Impaired healing	17.21	12.45	6	30484	87649	79626249
Nasal disorder	17.04	12.45	13	30477	3756	79710142
Tongue oedema	16.87	12.45	17	30473	7100	79706798
Chills	16.76	12.45	22	30468	160212	79553686
Chronic obstructive pulmonary disease	16.51	12.45	6	30484	85413	79628485
Atypical haemolytic uraemic syndrome	16.47	12.45	8	30482	1024	79712874
Dyspnoea	16.43	12.45	230	30260	856795	78857103
Intervertebral discitis	16.21	12.45	14	30476	4814	79709084
Off label use	16.16	12.45	247	30243	906968	78806930
Vomiting	16.14	12.45	350	30140	665478	79048420
Urinary retention	16.11	12.45	53	30437	56577	79657321
Mixed anxiety and depressive disorder	15.98	12.45	6	30484	407	79713491
Shock haemorrhagic	15.93	12.45	28	30462	20032	79693866
Hyperkalaemia	15.91	12.45	86	30404	114312	79599586
Arthralgia	15.88	12.45	141	30349	571662	79142236
Gastrointestinal disorder	15.87	12.45	14	30476	122191	79591707
Product dispensing issue	15.72	12.45	5	30485	206	79713692
Hypertransaminasaemia	15.64	12.45	21	30469	11903	79701995
Knee arthroplasty	15.61	12.45	44	30446	43204	79670694
Allodynia	15.56	12.45	9	30481	1639	79712259
Septic shock	15.54	12.45	90	30400	122711	79591187
Oedematous pancreatitis	15.53	12.45	8	30482	1160	79712738
Nasal congestion	15.44	12.45	5	30485	76547	79637351
Dermo-hypodermitis	15.32	12.45	7	30483	781	79713117
Eosinophilia	15.27	12.45	45	30445	45300	79668598
Colon cancer	15.25	12.45	23	30467	14500	79699398
Skin turgor decreased	15.24	12.45	7	30483	791	79713107
Staphylococcal sepsis	15.00	12.45	23	30467	14703	79699195
Vanishing bile duct syndrome	14.93	12.45	9	30481	1769	79712129
Necrotising myositis	14.91	12.45	8	30482	1260	79712638
Disease progression	14.89	12.45	30	30460	184332	79529566
Reversible cerebral vasoconstriction syndrome	14.83	12.45	11	30479	3046	79710852
Stress	14.71	12.45	6	30484	79606	79634292
Mobility decreased	14.69	12.45	15	30475	122160	79591738
Hepatic failure	14.57	12.45	54	30436	61158	79652740
Fracture displacement	14.57	12.45	8	30482	1320	79712578
Muscle spasms	14.48	12.45	28	30462	174702	79539196
Odontogenic cyst	14.38	12.45	3	30487	21	79713877
Prothrombin time shortened	14.30	12.45	11	30479	3217	79710681
Flushing	14.24	12.45	8	30482	88260	79625638
Schizophrenia	14.19	12.45	23	30467	15417	79698481
Brain empyema	14.14	12.45	3	30487	23	79713875
Social anxiety disorder	14.10	12.45	6	30484	565	79713333
Adverse drug reaction	14.00	12.45	4	30486	66388	79647510
Hepatitis	13.97	12.45	50	30440	55677	79658221
Adverse event	13.92	12.45	3	30487	60211	79653687
Duplicate therapy error	13.88	12.45	5	30485	302	79713596
Endothelin increased	13.71	12.45	3	30487	27	79713871
Infection	13.67	12.45	47	30443	241665	79472233
Meningitis aseptic	13.66	12.45	15	30475	6913	79706985
Renal vasculitis	13.58	12.45	6	30484	619	79713279
Pain in extremity	13.41	12.45	83	30407	364455	79349443
Drug-disease interaction	13.18	12.45	7	30483	1080	79712818
Pneumococcal sepsis	12.90	12.45	8	30482	1654	79712244
Type 2 diabetes mellitus	12.89	12.45	3	30487	57119	79656779
Diarrhoea infectious	12.85	12.45	8	30482	1666	79712232
Cough	12.73	12.45	85	30405	366704	79347194
Metastases to lung	12.71	12.45	24	30466	18139	79695759
Injury	12.54	12.45	7	30483	77489	79636409
Cardiac failure congestive	12.53	12.45	22	30468	142380	79571518
Allergic colitis	12.50	12.45	3	30487	42	79713856
Pancreatitis necrotising	12.46	12.45	11	30479	3897	79710001

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	M01AE03	MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Propionic acid derivatives
ATC	M01AE53	MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Propionic acid derivatives
ATC	M02AA10	MUSCULO-SKELETAL SYSTEM TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN Antiinflammatory preparations, non-steroids for topical use
FDA CS	M0001335	Anti-Inflammatory Agents, Non-Steroidal
FDA MoA	N0000000160	Cyclooxygenase Inhibitors
MeSH PA	D000700	Analgesics
MeSH PA	D018712	Analgesics, Non-Narcotic
MeSH PA	D000893	Anti-Inflammatory Agents
MeSH PA	D000894	Anti-Inflammatory Agents, Non-Steroidal
MeSH PA	D018501	Antirheumatic Agents
MeSH PA	D016861	Cyclooxygenase Inhibitors
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D018689	Sensory System Agents
CHEBI has role	CHEBI:35475	non-steroidal anti-inflammatory agent
CHEBI has role	CHEBI:35493	anti-pyretic
CHEBI has role	CHEBI:35544	cyclooxygenase inhibitors
CHEBI has role	CHEBI:35703	Xenobiotic
CHEBI has role	CHEBI:78298	environmental contaminants
CHEBI has role	CHEBI:88188	allergenic drug
FDA EPC	N0000175722	Nonsteroidal Anti-inflammatory Drug

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Pain	indication	22253000
Rheumatoid arthritis	indication	69896004	DOID:7148
Dysmenorrhea	indication	266599000
Osteoarthritis	indication	396275006
Ankylosing spondylitis	off-label use	9631008	DOID:7147
Gout	off-label use	90560007	DOID:13189
Vascular headache	off-label use	128187005
Peptic ulcer	contraindication	13200003	DOID:750
Myocardial infarction	contraindication	22298006	DOID:5844
Hypertensive disorder	contraindication	38341003	DOID:10763
Gastrointestinal ulcer	contraindication	40845000
Chronic heart failure	contraindication	48447003
Disorder of cardiovascular system	contraindication	49601007	DOID:1287
Hepatic failure	contraindication	59927004
Blood coagulation disorder	contraindication	64779008	DOID:1247
Gastrointestinal hemorrhage	contraindication	74474003
Kidney disease	contraindication	90708001	DOID:557
Hypoalbuminemia	contraindication	119247004
Coronary artery bypass graft	contraindication	232717009
Pregnancy, function	contraindication	289908002
Cardiovascular event risk	contraindication	395112001
Smokes tobacco daily	contraindication	449868002

🐶 Veterinary Drug Use

Species	Use	Relation
Horses	Pain and inflammation associated with musculoskeletal disorders	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
KETOFEN	Zoetis Inc.	1
Draxxin KP	Zoetis Inc.	2
KetoMed	Bimeda Animal Health Limited	1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.28	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Prostaglandin G/H synthase 2	Enzyme	P35354	PGH2_HUMAN	INHIBITOR	IC50	6.62	WOMBAT-PK	CHEMBL
Prostaglandin G/H synthase 1	Enzyme	P23219	PGH1_HUMAN	INHIBITOR	IC50	7.33	WOMBAT-PK	CHEMBL
Prostaglandin G/H synthase 1	Enzyme		PGH1_SHEEP		IC50	6.10	CHEMBL
Prostaglandin G/H synthase 2	Enzyme		PGH2_SHEEP		IC50	6.75	CHEMBL
Cyclooxygenase	Enzyme		PGH1_BOVIN PGH2_BOVIN		IC50	5.47	CHEMBL

External reference:

ID	Source
4018064	VUID
N0000146405	NUI
D00132	KEGG_DRUG
4018064	VANDF
C0022635	UMLSCUI
CHEBI:6128	CHEBI
CHEMBL571	ChEMBL_ID
DB01009	DRUGBANK_ID
D007660	MESH_DESCRIPTOR_UI
3825	PUBCHEM_CID
4795	IUPHAR_LIGAND_ID
3284	INN_ID
90Y4QC304K	UNII
6142	RXNORM
3365	MMSL
4946	MMSL
d00028	MMSL
002394	NDDF
10099000	SNOMEDCT_US
386832008	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	0276-0504	CAPSULE	25 mg	ORAL	ANDA	23 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	0276-0504	CAPSULE	25 mg	ORAL	ANDA	23 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	0276-0506	CAPSULE	50 mg	ORAL	ANDA	23 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	0378-8200	CAPSULE, EXTENDED RELEASE	200 mg	ORAL	ANDA	29 sections
KETOPROFEN	HUMAN PRESCRIPTION DRUG LABEL	1	16590-136	CAPSULE	50 mg	ORAL	ANDA	28 sections
KETOPROFEN	HUMAN PRESCRIPTION DRUG LABEL	1	16590-137	CAPSULE	75 mg	ORAL	ANDA	28 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	21695-340	CAPSULE	50 mg	ORAL	ANDA	30 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	21695-341	CAPSULE	75 mg	ORAL	ANDA	30 sections
ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	23155-020	CAPSULE	25 mg	ORAL	ANDA	13 sections
ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	23155-021	CAPSULE	50 mg	ORAL	ANDA	13 sections
ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	23155-022	CAPSULE	75 mg	ORAL	ANDA	13 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	33261-064	CAPSULE	75 mg	ORAL	ANDA	28 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	42254-037	CAPSULE	75 mg	ORAL	ANDA	28 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	45865-379	CAPSULE	75 mg	ORAL	ANDA	28 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	45865-485	CAPSULE	50 mg	ORAL	ANDA	28 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	50090-0453	CAPSULE	75 mg	ORAL	ANDA	28 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	50090-2729	CAPSULE	50 mg	ORAL	ANDA	28 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	52959-245	CAPSULE	50 mg	ORAL	ANDA	28 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	53217-221	CAPSULE	50 mg	ORAL	ANDA	28 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	54868-2414	CAPSULE	50 mg	ORAL	ANDA	30 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	54868-2415	CAPSULE	75 mg	ORAL	ANDA	30 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	54868-4826	CAPSULE, EXTENDED RELEASE	200 mg	ORAL	ANDA	30 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	63187-018	CAPSULE	75 mg	ORAL	ANDA	28 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	67296-0369	TABLET	75 mg	ORAL	ANDA	28 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	69336-127	CAPSULE	25 mg	ORAL	ANDA	14 sections