ketoprofen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory agents, ibuprofen derivatives 1528 22071-15-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • RP 19583
  • RP-19583
  • ketoprofen
  • ketoprofene
  • ketoprophen
An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It is used in the treatment of rheumatoid arthritis and osteoarthritis.
  • Molecular weight: 254.29
  • Formula: C16H14O3
  • CLOGP: 2.76
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 54.37
  • ALOGS: -4.08
  • ROTB: 4
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.15 g O
0.15 g P
0.15 g R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 19.66 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 90 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.13 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.60 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.10 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,EIF2AK3,GRK2,PDK1,PDK2,PDK4 6
kinase-selectivity-class AXL,EIF2AK3,GRK2,PDK4,PIK3CD 5
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 1.574 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1

Approvals:

DateAgencyCompanyOrphan
Jan. 9, 1986 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Food allergy 1087.66 13.33 397 34179 25081 90568790
Temperature regulation disorder 971.58 13.33 317 34259 14262 90579609
Immunodeficiency 929.36 13.33 411 34165 42823 90551048
Rash erythematous 683.23 13.33 380 34196 64724 90529147
Hyperhidrosis 547.38 13.33 437 34139 135868 90458003
Coeliac disease 544.72 13.33 288 34288 44322 90549549
Overdose 479.79 13.33 431 34145 157278 90436593
Intentional product misuse 476.58 13.33 340 34236 89264 90504607
Foetal death 474.08 13.33 206 34370 20517 90573354
Upper respiratory tract infection 472.08 13.33 391 34185 127927 90465944
Fluid retention 454.13 13.33 328 34248 87763 90506108
Prescribed overdose 362.03 13.33 299 34277 97326 90496545
Asthma 312.99 13.33 422 34154 241738 90352133
Erythema 309.31 13.33 408 34168 228838 90365033
Bursitis 273.05 13.33 292 34284 131362 90462509
Exposure during pregnancy 244.07 13.33 372 34204 238038 90355833
Rheumatoid arthritis 239.84 13.33 466 34110 362148 90231723
Constipation 226.54 13.33 393 34183 280002 90313869
Thrombocytopenia 216.85 13.33 328 34248 208397 90385474
Acute generalised exanthematous pustulosis 200.47 13.33 100 34476 13603 90580268
Hepatic enzyme increased 195.31 13.33 427 34149 360309 90233562
Psoriasis 166.00 13.33 241 34335 147513 90446358
Hypersensitivity 156.45 13.33 453 34123 454224 90139647
Back pain 151.05 13.33 357 34219 316818 90277053
Acute kidney injury 146.52 13.33 355 34221 320032 90273839
Hepatic cytolysis 140.88 13.33 107 34469 30809 90563062
Amyloid arthropathy 134.33 13.33 42 34534 1638 90592233
Product use issue 132.49 13.33 348 34228 329571 90264300
Pulmonary pain 127.30 13.33 54 34522 5060 90588811
Glossodynia 105.27 13.33 4 34572 321775 90272096
Alopecia 100.42 13.33 32 34544 495039 90098832
Poisoning deliberate 100.23 13.33 68 34508 16418 90577453
Decreased immune responsiveness 99.70 13.33 54 34522 8694 90585177
Systemic lupus erythematosus 99.47 13.33 11 34565 361885 90231986
Hepatocellular injury 95.50 13.33 83 34493 28875 90564996
Suicide attempt 91.99 13.33 128 34448 75271 90518600
Face oedema 87.51 13.33 72 34504 23246 90570625
Headache 87.45 13.33 595 33981 862151 89731720
Wound 83.78 13.33 9 34567 302971 90290900
Synovitis 83.48 13.33 13 34563 329739 90264132
Cholestasis 83.15 13.33 85 34491 36214 90557657
Hypertension 82.32 13.33 369 34207 457163 90136708
Drug abuse 80.55 13.33 126 34450 82221 90511650
Angioedema 80.43 13.33 111 34465 64765 90529106
Hand deformity 78.97 13.33 10 34566 296352 90297519
Anaphylactic shock 77.86 13.33 77 34499 31540 90562331
Goitre 72.22 13.33 40 34536 6727 90587144
Contraindicated product administered 71.49 13.33 276 34300 319863 90274008
Pericarditis 69.86 13.33 10 34566 270141 90323730
Drug hypersensitivity 67.57 13.33 352 34224 463257 90130614
Pyrexia 65.86 13.33 454 34122 660031 89933840
Type 2 diabetes mellitus 64.86 13.33 3 34573 203241 90390630
Sinusitis 64.67 13.33 25 34551 343063 90250808
Coma 64.01 13.33 106 34470 72526 90521345
Fibromyalgia 62.86 13.33 4 34572 206265 90387606
Duodenal ulcer perforation 62.65 13.33 6 34570 221282 90372589
Joint swelling 62.55 13.33 366 34210 502934 90090937
Folliculitis 62.16 13.33 4 34572 204349 90389522
Lactic acidosis 62.03 13.33 86 34490 50377 90543494
Mobility decreased 60.97 13.33 11 34565 250723 90343148
Helicobacter infection 59.59 13.33 8 34568 226842 90367029
Infusion related reaction 58.33 13.33 313 34263 416467 90177404
Impaired healing 57.54 13.33 10 34566 234189 90359682
Peripheral nerve injury 57.10 13.33 18 34558 721 90593150
Therapeutic product effect decreased 56.11 13.33 18 34558 277553 90316318
Muscle injury 55.12 13.33 3 34573 176651 90417220
Spinal epidural haemorrhage 53.36 13.33 14 34562 287 90593584
Blister 52.50 13.33 16 34560 254982 90338889
Ill-defined disorder 52.37 13.33 5 34571 184886 90408985
Psoriatic arthropathy 51.41 13.33 12 34564 228323 90365548
Weight increased 49.35 13.33 52 34524 417875 90175996
Drug interaction 48.89 13.33 222 34354 276231 90317640
Hypoaesthesia 48.44 13.33 30 34546 314180 90279691
Epidural haemorrhage 48.05 13.33 13 34563 301 90593570
Intentional overdose 47.13 13.33 108 34468 93726 90500145
Intentional product use issue 45.76 13.33 13 34563 216879 90376992
Death 44.30 13.33 66 34510 456485 90137386
Pain 42.41 13.33 572 34004 995769 89598102
Melaena 42.31 13.33 59 34517 34738 90559133
Allergy test negative 41.91 13.33 11 34565 226 90593645
Gastric ulcer 41.83 13.33 52 34524 27396 90566475
Gastrointestinal disorder 41.69 13.33 23 34553 256664 90337207
Lip and/or oral cavity cancer 41.65 13.33 15 34561 907 90592964
Injury 41.31 13.33 12 34564 197337 90396534
Muscle spasms 40.29 13.33 23 34553 251860 90342011
Joint range of motion decreased 40.24 13.33 3 34573 135640 90458231
Rash 39.78 13.33 471 34105 795629 89798242
Dermo-hypodermitis 39.75 13.33 14 34562 793 90593078
Blood cholesterol increased 39.43 13.33 15 34561 207997 90385874
Completed suicide 38.36 13.33 5 34571 145053 90448818
Inflammatory bowel disease 37.95 13.33 24 34552 5147 90588724
Wheezing 37.70 13.33 22 34554 238058 90355813
Dyspnoea 36.34 13.33 193 34383 880762 89713109
Contusion 35.99 13.33 26 34550 251190 90342681
Abdominal discomfort 35.63 13.33 81 34495 477247 90116624
Hepatic adenoma 35.20 13.33 11 34565 428 90593443
Discomfort 34.82 13.33 32 34544 274303 90319568
Renal cortical necrosis 34.72 13.33 10 34566 293 90593578
Arthralgia 34.69 13.33 166 34410 778356 89815515
Drug reaction with eosinophilia and systemic symptoms 34.48 13.33 60 34516 42698 90551173
Gait inability 34.37 13.33 7 34569 146449 90447422
Aspirin-exacerbated respiratory disease 34.10 13.33 12 34564 678 90593193
Swelling 33.87 13.33 68 34508 418990 90174881
Sleep disorder 33.24 13.33 17 34559 198013 90395858
Pneumonia 32.70 13.33 129 34447 637930 89955941
Toxic skin eruption 32.65 13.33 35 34541 15739 90578132
Hospitalisation 32.50 13.33 5 34571 128095 90465776
Type I hypersensitivity 32.29 13.33 20 34556 4135 90589736
Treatment failure 32.01 13.33 212 34364 303716 90290155
Anxiety 31.79 13.33 43 34533 309729 90284142
Peripheral swelling 31.73 13.33 69 34507 413037 90180834
Central pain syndrome 30.64 13.33 11 34565 659 90593212
Epidural analgesia 30.54 13.33 8 34568 163 90593708
Procedure aborted 30.31 13.33 8 34568 168 90593703
Foetal heart rate abnormal 30.22 13.33 12 34564 950 90592921
Disease progression 30.17 13.33 11 34565 156604 90437267
Pancreatitis acute 29.81 13.33 48 34528 32067 90561804
Insomnia 29.69 13.33 51 34525 333423 90260448
Depression 29.58 13.33 43 34533 300558 90293313
Migraine 29.57 13.33 18 34558 190374 90403497
Femoral artery dissection 29.43 13.33 6 34570 37 90593834
Diarrhoea 28.41 13.33 226 34350 938964 89654907
Osteoarthritis 28.37 13.33 20 34556 195710 90398161
Burning mouth syndrome 27.95 13.33 10 34566 593 90593278
Tubulointerstitial nephritis 27.92 13.33 41 34535 25302 90568569
Confusional state 27.64 13.33 67 34509 386138 90207733
Memory impairment 27.49 13.33 21 34555 197223 90396648
Hepatic function abnormal 27.47 13.33 57 34519 46231 90547640
Endocarditis staphylococcal 26.87 13.33 9 34567 438 90593433
Adverse event 26.76 13.33 6 34570 117412 90476459
Liver injury 26.66 13.33 16 34560 170551 90423320
Dyspepsia 26.49 13.33 22 34554 198138 90395733
Sinoatrial block 26.31 13.33 11 34565 994 90592877
C-reactive protein abnormal 26.20 13.33 8 34568 127421 90466450
Rash maculo-papular 26.19 13.33 52 34524 40881 90552990
Hepatitis acute 25.85 13.33 26 34550 10861 90583010
Gastritis erosive 25.64 13.33 21 34555 6734 90587137
Retching 25.58 13.33 34 34542 19125 90574746
Lip dry 25.47 13.33 4 34572 100951 90492920
Ankylosing spondylitis 25.20 13.33 28 34548 13105 90580766
Reversible cerebral vasoconstriction syndrome 25.01 13.33 17 34559 4113 90589758
Grip strength decreased 24.94 13.33 3 34573 92573 90501298
Night sweats 24.88 13.33 9 34567 128757 90465114
Somnolence 24.57 13.33 150 34426 208934 90384937
Altered state of consciousness 23.82 13.33 43 34533 31489 90562382
Infusion site infection 23.76 13.33 14 34562 2646 90591225
Upper respiratory tract inflammation 23.70 13.33 14 34562 2658 90591213
Nasopharyngitis 23.68 13.33 78 34498 407026 90186845
Glomerulonephropathy 23.50 13.33 6 34570 110 90593761
Pneumoperitoneum 23.32 13.33 12 34564 1741 90592130
Fine motor skill dysfunction 23.02 13.33 18 34558 5401 90588470
Infection 23.01 13.33 225 34351 361869 90232002
Sphincter of Oddi dysfunction 22.80 13.33 8 34568 448 90593423
Stomatitis 22.67 13.33 44 34532 274654 90319217
Meningoencephalitis bacterial 22.61 13.33 7 34569 264 90593607
Maternal exposure during pregnancy 22.34 13.33 67 34509 359996 90233875
Peripheral venous disease 21.93 13.33 3 34573 83918 90509953
Toxic epidermal necrolysis 21.63 13.33 42 34534 32486 90561385
Sciatica 21.51 13.33 6 34570 101376 90492495
Nasal disorder 21.02 13.33 14 34562 3278 90590593
Hepatitis fulminant 21.00 13.33 15 34561 3930 90589941
Food interaction 20.80 13.33 10 34566 1254 90592617
Pneumococcal sepsis 20.57 13.33 9 34567 909 90592962
Dizziness 20.07 13.33 137 34439 589147 90004724
Vanishing bile duct syndrome 20.02 13.33 10 34566 1362 90592509
Dermatitis bullous 19.80 13.33 22 34554 10294 90583577
Nasal congestion 19.54 13.33 4 34572 83410 90510461
Meningitis aseptic 19.53 13.33 18 34558 6755 90587116
Autoimmune disorder 19.45 13.33 3 34573 76741 90517130
Device wireless communication issue 19.37 13.33 5 34571 96 90593775
Poor sucking reflex 19.21 13.33 7 34569 438 90593433
Septic shock 19.09 13.33 73 34503 84087 90509784
COVID-19 18.81 13.33 22 34554 168821 90425050
Thyroid cancer 18.70 13.33 17 34559 6267 90587604
General physical health deterioration 18.67 13.33 71 34505 355044 90238827
Duplicate therapy error 18.51 13.33 5 34571 115 90593756
Fall 18.47 13.33 108 34468 481702 90112169
Pulmonary fibrosis 18.38 13.33 9 34567 107494 90486377
Gastrooesophageal reflux disease 18.18 13.33 22 34554 166315 90427556
Condition aggravated 18.10 13.33 143 34433 595402 89998469
Gastroenteropancreatic neuroendocrine tumour disease 18.10 13.33 4 34572 38 90593833
Lower limb fracture 18.10 13.33 5 34571 85008 90508863
Wound infection 18.05 13.33 9 34567 106393 90487478
Muscular weakness 18.02 13.33 32 34544 206634 90387237
Fixed eruption 17.84 13.33 10 34566 1720 90592151
Toxic shock syndrome streptococcal 17.75 13.33 6 34570 300 90593571
Hyperaesthesia 17.48 13.33 21 34555 10681 90583190
Drug intolerance 17.32 13.33 253 34323 447338 90146533
Drug dependence 17.27 13.33 36 34540 29291 90564580
Hip arthroplasty 17.15 13.33 4 34572 76204 90517667
Cell death 17.15 13.33 12 34564 3043 90590828
Enteritis infectious 17.12 13.33 11 34565 2424 90591447
Stress 16.93 13.33 5 34571 81390 90512481
Injection site pain 16.92 13.33 25 34551 173674 90420197
Atypical haemolytic uraemic syndrome 16.80 13.33 8 34568 983 90592888
Lip oedema 16.73 13.33 14 34562 4625 90589246
Pleural calcification 16.61 13.33 4 34572 57 90593814
Foetal exposure during delivery 16.48 13.33 6 34570 374 90593497
Diaphragmatic hernia 16.46 13.33 7 34569 660 90593211
Chronic obstructive pulmonary disease 16.37 13.33 4 34572 73825 90520046
Anuria 16.36 13.33 24 34552 14794 90579077
Arthritis bacterial 16.26 13.33 17 34559 7428 90586443
Thyroid hormones decreased 16.24 13.33 7 34569 682 90593189
Eyelid oedema 16.22 13.33 21 34555 11513 90582358
Osteomyelitis 16.18 13.33 34 34542 27812 90566059
Nausea 16.07 13.33 313 34263 1110003 89483868
Therapeutic product effect incomplete 16.04 13.33 31 34545 193865 90400006
Gastroduodenal ulcer 16.01 13.33 6 34570 406 90593465
Joint stiffness 15.86 13.33 5 34571 78037 90515834
Amnesia 15.83 13.33 11 34565 108494 90485377
Arthropathy 15.73 13.33 79 34497 366163 90227708
Mixed anxiety and depressive disorder 15.72 13.33 6 34570 427 90593444
Upper gastrointestinal haemorrhage 15.68 13.33 30 34546 22946 90570925
Adverse drug reaction 15.53 13.33 13 34563 116688 90477183
Oedematous pancreatitis 15.36 13.33 7 34569 778 90593093
Linear IgA disease 15.32 13.33 10 34566 2264 90591607
Anaphylactic reaction 15.22 13.33 70 34506 87454 90506417
Vascular purpura 15.14 13.33 9 34567 1729 90592142
Ventricular hypokinesia 15.02 13.33 14 34562 5327 90588544
C-reactive protein increased 15.00 13.33 29 34547 181360 90412511
Pericardial disease 14.97 13.33 5 34571 241 90593630
Pancreatitis necrotising 14.90 13.33 10 34566 2371 90591500
Loss of personal independence in daily activities 14.87 13.33 18 34558 136087 90457784
Pyelonephritis acute 14.82 13.33 14 34562 5418 90588453
Liver function test increased 14.66 13.33 7 34569 84848 90509023
Influenza 14.61 13.33 19 34557 139245 90454626
Miosis 14.50 13.33 18 34558 9466 90584405
Dermatitis exfoliative generalised 14.47 13.33 14 34562 5579 90588292
Taste disorder 14.31 13.33 3 34573 61543 90532328
Road traffic accident 14.31 13.33 12 34564 107614 90486257
Aortic aneurysm rupture 14.28 13.33 6 34570 549 90593322
Metabolic acidosis 14.06 13.33 50 34526 55626 90538245
Red blood cell sedimentation rate increased 13.99 13.33 7 34569 82588 90511283
Drug level increased 13.98 13.33 32 34544 27730 90566141
Visual impairment 13.95 13.33 18 34558 132347 90461524
Product administration error 13.91 13.33 31 34545 26392 90567479
Chills 13.85 13.33 18 34558 131963 90461908
Odontogenic cyst 13.82 13.33 3 34573 26 90593845
Infusion site pain 13.75 13.33 26 34550 19712 90574159
Hypercholesterolaemia 13.73 13.33 11 34565 100881 90492990
Endothelin increased 13.72 13.33 3 34573 27 90593844
Hyperkalaemia 13.64 13.33 55 34521 64909 90528962
Anticholinergic syndrome 13.62 13.33 10 34566 2733 90591138
Alpha tumour necrosis factor increased 13.53 13.33 3 34573 29 90593842
Social anxiety disorder 13.52 13.33 6 34570 627 90593244
Fasciitis 13.45 13.33 6 34570 635 90593236

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 159.83 14.35 376 14442 366961 42239556
Angioedema 144.45 14.35 119 14699 42358 42564159
Anaphylactic shock 90.77 14.35 71 14747 23446 42583071
Hyperaesthesia 83.56 14.35 41 14777 5911 42600606
Radiation inflammation 81.10 14.35 25 14793 1023 42605494
Acute generalised exanthematous pustulosis 77.38 14.35 44 14774 8551 42597966
Myoclonic epilepsy 73.39 14.35 26 14792 1648 42604869
Lactic acidosis 72.58 14.35 84 14734 45177 42561340
Pulmonary pain 71.05 14.35 25 14793 1553 42604964
Pancreatitis acute 69.00 14.35 71 14747 33493 42573024
Drug interaction 66.74 14.35 224 14594 266775 42339742
Poisoning deliberate 63.19 14.35 41 14777 10093 42596424
Polyneuropathy in malignant disease 61.06 14.35 16 14802 360 42606157
Death 59.86 14.35 46 14772 471139 42135378
Suicide attempt 58.44 14.35 76 14742 46024 42560493
Vascular purpura 56.21 14.35 23 14795 2163 42604354
Allergy test negative 52.04 14.35 12 14806 155 42606362
Intentional overdose 50.50 14.35 75 14743 51381 42555136
Anorgasmia 47.35 14.35 17 14801 1120 42605397
Hepatocellular injury 46.69 14.35 49 14769 23629 42582888
Hyperleukocytosis 45.91 14.35 21 14797 2587 42603930
Mixed liver injury 43.24 14.35 24 14794 4450 42602067
Cholestasis 42.90 14.35 55 14763 32824 42573693
Lung neoplasm malignant 42.06 14.35 42 14776 19105 42587412
Confusion postoperative 41.73 14.35 10 14808 154 42606363
Off label use 41.13 14.35 102 14716 638233 41968284
Vomiting 41.05 14.35 204 14614 289519 42316998
Allodynia 40.51 14.35 15 14803 1079 42605438
Eyelid oedema 40.39 14.35 25 14793 5670 42600847
Type I hypersensitivity 39.90 14.35 18 14800 2148 42604369
Erythema 38.15 14.35 103 14715 108690 42497827
Gastric ulcer 36.38 14.35 38 14780 18224 42588293
Coma 36.22 14.35 66 14752 53488 42553029
Genital pain 35.63 14.35 13 14805 897 42605620
Melaena 34.50 14.35 54 14764 38692 42567825
Drug level increased 34.45 14.35 44 14774 26156 42580361
Palatal oedema 34.13 14.35 13 14805 1011 42605506
Brain injury 33.68 14.35 25 14793 7630 42598887
Metastases to lung 32.65 14.35 29 14789 11395 42595122
Fatigue 32.59 14.35 64 14754 435577 42170940
Hepatitis cholestatic 32.26 14.35 27 14791 9797 42596720
Genital ulceration 32.20 14.35 12 14806 879 42605638
Hepatic cytolysis 32.06 14.35 43 14775 26801 42579716
Electrocardiogram T wave peaked 30.20 14.35 11 14807 755 42605762
Severe invasive streptococcal infection 29.71 14.35 6 14812 39 42606478
Pallor 29.62 14.35 43 14775 28843 42577674
Postoperative delirium 28.91 14.35 10 14808 590 42605927
Prothrombin time abnormal 28.68 14.35 11 14807 872 42605645
Vitello-intestinal duct remnant 27.35 14.35 7 14811 143 42606374
Schizophrenia 26.67 14.35 25 14793 10525 42595992
Enterocolitis 26.01 14.35 24 14794 9905 42596612
Blood lactic acid 25.70 14.35 8 14810 338 42606179
Gastric ulcer haemorrhage 24.72 14.35 19 14799 6108 42600409
Tongue oedema 24.67 14.35 15 14803 3295 42603222
Laryngeal discomfort 23.92 14.35 7 14811 239 42606278
Dermatitis bullous 23.24 14.35 21 14797 8435 42598082
Inflammation 23.24 14.35 42 14776 33805 42572712
Metastases to bone 22.91 14.35 27 14791 14782 42591735
Lip oedema 22.64 14.35 14 14804 3170 42603347
Rhinitis allergic 22.62 14.35 15 14803 3827 42602690
Overdose 22.47 14.35 84 14734 105180 42501337
Quality of life decreased 22.41 14.35 17 14801 5359 42601158
Rash pustular 22.33 14.35 18 14800 6197 42600320
Renal artery dissection 22.32 14.35 4 14814 12 42606505
Food poisoning 22.08 14.35 13 14805 2693 42603824
Anaphylactic reaction 22.01 14.35 47 14771 42696 42563821
Derealisation 21.99 14.35 9 14809 846 42605671
Brain empyema 21.63 14.35 4 14814 15 42606502
Fusobacterium infection 21.58 14.35 6 14812 170 42606347
Eosinophilia 21.54 14.35 40 14778 32859 42573658
Drug dependence 21.13 14.35 37 14781 29057 42577460
Cholecystitis chronic 21.12 14.35 9 14809 936 42605581
Intentional product misuse 21.07 14.35 58 14760 61842 42544675
Toxicity to various agents 21.05 14.35 144 14674 228992 42377525
Intervertebral discitis 20.49 14.35 13 14805 3077 42603440
Mutism 20.30 14.35 10 14808 1452 42605065
Diarrhoea infectious 20.28 14.35 8 14810 684 42605833
Rash maculo-papular 20.20 14.35 42 14776 37461 42569056
Renal vasculitis 19.71 14.35 6 14812 235 42606282
Hyperkalaemia 19.55 14.35 67 14751 80391 42526126
Toxic skin eruption 19.55 14.35 24 14794 13706 42592811
Arthropathy 19.40 14.35 36 14782 29561 42576956
Gastrointestinal pain 18.49 14.35 14 14804 4401 42602116
Dyschezia 18.43 14.35 10 14808 1774 42604743
Irritable bowel syndrome 17.76 14.35 14 14804 4667 42601850
Abdominal pain upper 17.68 14.35 66 14752 82543 42523974
Vernal keratoconjunctivitis 17.47 14.35 4 14814 50 42606467
Allergy test positive 17.16 14.35 5 14813 168 42606349
Meningoencephalitis bacterial 17.14 14.35 5 14813 169 42606348
Knee arthroplasty 17.00 14.35 18 14800 8763 42597754
Drug reaction with eosinophilia and systemic symptoms 16.95 14.35 42 14776 42033 42564484
Livedo reticularis 16.78 14.35 11 14807 2753 42603764
Prothrombin time shortened 16.67 14.35 9 14809 1580 42604937
Necrotising myositis 16.43 14.35 8 14810 1133 42605384
Anaemia 16.42 14.35 159 14659 280119 42326398
Epilepsy congenital 16.07 14.35 3 14815 12 42606505
Retroperitoneal fibrosis 16.01 14.35 6 14812 446 42606071
Cerebrovascular accident 15.79 14.35 7 14811 97153 42509364
Peritonsillar abscess 15.39 14.35 6 14812 497 42606020
Drug ineffective 15.28 14.35 143 14675 630054 41976463
Miosis 15.23 14.35 21 14797 13425 42593092
Dermatofibrosarcoma protuberans 14.92 14.35 3 14815 19 42606498
Urticaria 14.89 14.35 58 14760 73978 42532539
Altered state of consciousness 14.86 14.35 32 14786 29227 42577290
Affective disorder 14.82 14.35 14 14804 5946 42600571
Anterograde amnesia 14.46 14.35 5 14813 295 42606222
Hepatic function abnormal 14.37 14.35 45 14773 51522 42554995

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Temperature regulation disorder 858.13 12.45 281 42656 12545 110533817
Food allergy 754.81 12.45 286 42651 19662 110526700
Immunodeficiency 607.18 12.45 298 42639 38540 110507822
Coeliac disease 531.52 12.45 282 42655 42905 110503457
Rash erythematous 406.17 12.45 300 42637 81532 110464830
Foetal death 405.28 12.45 172 42765 15873 110530489
Fluid retention 364.21 12.45 298 42639 94009 110452353
Erythema 348.90 12.45 494 42443 290953 110255409
Hyperhidrosis 294.33 12.45 363 42574 186935 110359427
Acute kidney injury 283.36 12.45 704 42233 634726 109911636
Overdose 282.16 12.45 398 42539 233396 110312966
Upper respiratory tract infection 281.59 12.45 299 42638 131029 110415333
Intentional product misuse 271.61 12.45 295 42642 132609 110413753
Acute generalised exanthematous pustulosis 259.49 12.45 139 42798 21525 110524837
Bursitis 257.88 12.45 284 42653 129634 110416728
Angioedema 250.64 12.45 246 42691 98254 110448108
Constipation 235.75 12.45 464 42473 357322 110189040
Pulmonary pain 198.12 12.45 79 42858 6214 110540148
Prescribed overdose 183.39 12.45 197 42740 87384 110458978
Asthma 172.49 12.45 331 42606 249960 110296402
Rheumatoid arthritis 165.99 12.45 362 42575 299251 110247111
Anaphylactic shock 160.37 12.45 144 42793 51402 110494960
Poisoning deliberate 154.59 12.45 107 42830 26224 110520138
Hepatic cytolysis 154.16 12.45 145 42792 54908 110491454
Back pain 145.22 12.45 392 42545 370604 110175758
Hepatocellular injury 137.25 12.45 131 42806 50511 110495851
Amyloid arthropathy 133.60 12.45 42 42895 1638 110544724
Suicide attempt 131.97 12.45 181 42756 103213 110443149
Psoriasis 131.19 12.45 212 42725 139781 110406581
Lactic acidosis 128.42 12.45 169 42768 92642 110453720
Cholestasis 117.59 12.45 135 42802 64383 110481979
Drug interaction 112.32 12.45 437 42500 499746 110046616
Hepatic enzyme increased 109.75 12.45 323 42614 320569 110225793
Hypersensitivity 103.19 12.45 368 42569 403630 110142732
Coma 93.82 12.45 166 42771 117703 110428659
Pancreatitis acute 93.19 12.45 116 42821 60158 110486204
Allergy test negative 91.55 12.45 23 42914 387 110545975
Hyperaesthesia 91.53 12.45 62 42875 14665 110531697
Decreased immune responsiveness 91.42 12.45 53 42884 9553 110536809
Contraindicated product administered 86.85 12.45 252 42685 248015 110298347
Face oedema 85.82 12.45 84 42853 33385 110512977
Death 85.78 12.45 87 42850 698782 109847580
Drug hypersensitivity 81.77 12.45 371 42566 453719 110092643
Radiation inflammation 78.37 12.45 25 42912 1023 110545339
Gastric ulcer 73.68 12.45 84 42853 39743 110506619
Intentional overdose 72.00 12.45 159 42778 132342 110414020
Synovitis 66.19 12.45 13 42924 274079 110272283
Drug abuse 65.83 12.45 184 42753 177227 110369135
Vascular purpura 65.11 12.45 31 42906 3740 110542622
Glossodynia 64.28 12.45 6 42931 221998 110324364
Melaena 64.20 12.45 104 42833 68653 110477709
Systemic lupus erythematosus 63.70 12.45 11 42926 254327 110292035
Pemphigus 61.59 12.45 6 42931 214564 110331798
Exposure during pregnancy 60.50 12.45 172 42765 167252 110379110
Completed suicide 57.47 12.45 12 42925 242369 110303993
Product use issue 57.04 12.45 256 42681 311439 110234923
Sinusitis 55.24 12.45 23 42914 296665 110249697
Type I hypersensitivity 54.88 12.45 33 42904 6360 110540002
Wound 54.78 12.45 12 42925 234425 110311937
Polyneuropathy in malignant disease 54.76 12.45 16 42921 485 110545877
Eyelid oedema 54.22 12.45 46 42891 15216 110531146
Hand deformity 53.52 12.45 10 42927 218496 110327866
Pericarditis 51.64 12.45 11 42926 219103 110327259
Fibromyalgia 51.17 12.45 4 42933 170905 110375457
Drug level increased 49.84 12.45 76 42861 47643 110498719
Weight increased 49.43 12.45 54 42883 419590 110126772
Peripheral nerve injury 49.02 12.45 18 42919 1130 110545232
Type 2 diabetes mellitus 48.22 12.45 6 42931 177226 110369136
Thrombocytopenia 47.15 12.45 263 42674 348622 110197740
Spinal epidural haemorrhage 46.88 12.45 13 42924 325 110546037
Mobility decreased 46.51 12.45 17 42920 237405 110308957
Impaired healing 46.10 12.45 10 42927 196707 110349655
Duodenal ulcer perforation 46.02 12.45 7 42930 177693 110368669
Toxic skin eruption 45.83 12.45 55 42882 27460 110518902
Helicobacter infection 45.24 12.45 8 42929 181869 110364493
Intentional product use issue 44.89 12.45 20 42917 247886 110298476
Epidural haemorrhage 44.30 12.45 13 42924 400 110545962
Alopecia 44.00 12.45 46 42891 364707 110181655
Drug reaction with eosinophilia and systemic symptoms 44.00 12.45 98 42839 81997 110464365
Hyperleukocytosis 43.81 12.45 23 42914 3416 110542946
Muscle injury 42.99 12.45 3 42934 140804 110405558
Meningoencephalitis bacterial 42.59 12.45 13 42924 459 110545903
Folliculitis 42.52 12.45 7 42930 167646 110378716
Mixed liver injury 42.07 12.45 36 42901 12043 110534319
Drug dependence 41.80 12.45 72 42865 49948 110496414
Dermo-hypodermitis 41.07 12.45 17 42920 1471 110544891
Aspirin-exacerbated respiratory disease 40.98 12.45 15 42922 933 110545429
Psoriatic arthropathy 40.42 12.45 13 42924 196748 110349614
Anaphylactic reaction 39.90 12.45 116 42821 114184 110432178
Dermatitis bullous 39.45 12.45 41 42896 17488 110528874
Anorgasmia 39.42 12.45 17 42920 1629 110544733
Rash maculo-papular 39.10 12.45 88 42849 74134 110472228
Wheezing 38.37 12.45 26 42911 255204 110291158
Hospitalisation 38.34 12.45 5 42932 142488 110403874
Altered state of consciousness 38.13 12.45 75 42862 57551 110488811
Lip and/or oral cavity cancer 37.67 12.45 15 42922 1175 110545187
Hepatitis cholestatic 37.59 12.45 40 42897 17526 110528836
Muscle spasms 37.14 12.45 32 42905 278125 110268237
Reversible cerebral vasoconstriction syndrome 36.84 12.45 23 42914 4738 110541624
Enterocolitis 36.81 12.45 41 42896 18908 110527454
Therapeutic product effect decreased 36.58 12.45 25 42912 244291 110302071
Tubulointerstitial nephritis 36.34 12.45 71 42866 54213 110492149
Lip oedema 35.73 12.45 27 42910 7573 110538789
Gastrointestinal disorder 34.60 12.45 26 42911 241926 110304436
Hepatic adenoma 34.34 12.45 11 42926 456 110545906
Swelling 34.27 12.45 52 42885 350989 110195373
Foetal heart rate abnormal 34.15 12.45 12 42925 663 110545699
Blister 33.07 12.45 24 42913 227352 110319010
Gastric ulcer haemorrhage 32.97 12.45 29 42908 10065 110536297
Severe invasive streptococcal infection 32.96 12.45 7 42930 53 110546309
Confusion postoperative 32.63 12.45 10 42927 358 110546004
Hepatitis acute 32.06 12.45 38 42899 18728 110527634
Goitre 31.31 12.45 23 42914 6181 110540181
Ankylosing spondylitis 30.70 12.45 34 42903 15578 110530784
Epidural analgesia 30.31 12.45 8 42929 165 110546197
Inflammatory bowel disease 30.30 12.45 24 42913 7210 110539152
Anxiety 30.08 12.45 55 42882 345023 110201339
Procedure aborted 29.95 12.45 8 42929 173 110546189
Allodynia 29.62 12.45 15 42922 2068 110544294
Hepatic function abnormal 29.61 12.45 89 42848 89206 110457156
Dizziness 29.59 12.45 155 42782 698038 109848324
Injury 29.51 12.45 16 42921 177249 110369113
Palatal oedema 29.43 12.45 14 42923 1686 110544676
Arthralgia 29.31 12.45 180 42757 779452 109766910
Renal cortical necrosis 29.15 12.45 10 42927 514 110545848
Genital pain 28.82 12.45 13 42924 1387 110544975
Laryngeal discomfort 28.78 12.45 11 42926 772 110545590
Endocarditis staphylococcal 28.67 12.45 12 42925 1068 110545294
Eosinophilia 28.64 12.45 67 42870 57869 110488493
Hypoaesthesia 28.36 12.45 49 42888 314174 110232188
Central pain syndrome 28.29 12.45 11 42926 809 110545553
Femoral artery dissection 28.19 12.45 6 42931 46 110546316
Gait inability 28.02 12.45 9 42928 136367 110409995
Migraine 27.85 12.45 16 42921 171636 110374726
C-reactive protein abnormal 27.66 12.45 8 42929 129687 110416675
Rash 27.36 12.45 459 42478 820505 109725857
Lung neoplasm malignant 27.34 12.45 48 42889 33794 110512568
Disease progression 26.99 12.45 33 42904 244001 110302361
Joint range of motion decreased 26.95 12.45 7 42930 121825 110424537
Osteoarthritis 26.92 12.45 19 42918 182604 110363758
Gastritis erosive 26.88 12.45 28 42909 11972 110534390
Pain in extremity 26.79 12.45 98 42839 487020 110059342
Intervertebral discitis 26.76 12.45 22 42915 6968 110539394
Burning mouth syndrome 26.59 12.45 10 42927 671 110545691
Cerebrovascular accident 26.53 12.45 19 42918 181265 110365097
Vitello-intestinal duct remnant 26.40 12.45 7 42930 147 110546215
Febrile neutropenia 26.28 12.45 52 42885 316715 110229647
Myelosuppression 26.14 12.45 3 42934 94337 110452025
Fall 26.11 12.45 133 42804 603349 109943013
Dyspnoea 25.92 12.45 290 42647 1106582 109439780
Peripheral swelling 25.87 12.45 76 42861 403958 110142404
Lip dry 25.78 12.45 4 42933 100079 110446283
Irritable bowel syndrome 25.66 12.45 16 42921 164199 110382163
Sleep disorder 25.14 12.45 24 42913 198620 110347742
Memory impairment 24.69 12.45 24 42913 196920 110349442
Genital ulceration 24.57 12.45 13 42924 1962 110544400
Cross sensitivity reaction 24.46 12.45 19 42918 5548 110540814
Night sweats 23.95 12.45 11 42926 133972 110412390
Blood cholesterol increased 23.77 12.45 22 42915 184763 110361599
Postoperative delirium 23.73 12.45 10 42927 905 110545457
Hyperkalaemia 23.66 12.45 110 42827 135686 110410676
Prothrombin time abnormal 23.55 12.45 11 42926 1271 110545091
Retching 23.50 12.45 36 42901 22646 110523716
Cough 23.38 12.45 96 42841 461545 110084817
Muscular weakness 23.11 12.45 38 42899 248430 110297932
Miosis 22.93 12.45 35 42902 21948 110524414
Treatment failure 22.90 12.45 185 42752 277049 110269313
Adverse event 22.68 12.45 7 42930 108802 110437560
Blood lactic acid 22.30 12.45 8 42929 470 110545892
Fixed eruption 22.06 12.45 16 42921 4216 110542146
Nasopharyngitis 21.90 12.45 79 42858 394282 110152080
Renal artery dissection 21.88 12.45 4 42933 12 110546350
Upper respiratory tract inflammation 21.60 12.45 16 42921 4355 110542007
Stress 21.56 12.45 7 42930 105341 110441021
Headache 21.40 12.45 470 42467 881907 109664455
Electrocardiogram T wave peaked 21.19 12.45 10 42927 1182 110545180
Grip strength decreased 21.12 12.45 3 42934 80171 110466191
Chronic obstructive pulmonary disease 21.06 12.45 8 42929 109150 110437212
Sciatica 21.03 12.45 5 42932 92394 110453968
Sphincter of Oddi dysfunction 20.68 12.45 8 42929 580 110545782
Allergy test positive 20.37 12.45 9 42928 914 110545448
Dermatofibrosarcoma protuberans 20.32 12.45 5 42932 77 110546285
Photosensitivity reaction 20.29 12.45 36 42901 25553 110520809
Meningitis aseptic 20.28 12.45 22 42915 9848 110536514
Anuria 20.28 12.45 35 42902 24306 110522056
Peripheral venous disease 20.27 12.45 4 42933 84113 110462249
Somnolence 20.15 12.45 190 42747 297259 110249103
Product quality issue 20.11 12.45 3 42934 77296 110469066
Septic shock 20.09 12.45 117 42820 157411 110388951
Osteomyelitis 19.95 12.45 44 42893 36556 110509806
Urinary retention 19.93 12.45 66 42871 69617 110476745
Knee arthroplasty 19.92 12.45 63 42874 64885 110481477
Pain 19.58 12.45 497 42440 954458 109591904
Prothrombin time shortened 19.50 12.45 14 42923 3632 110542730
Nasal congestion 19.30 12.45 7 42930 98275 110448087
Sinoatrial block 19.24 12.45 10 42927 1455 110544907
Fusobacterium infection 19.13 12.45 6 42931 232 110546130
Metastases to lung 19.01 12.45 33 42904 23030 110523332
Dyschezia 18.96 12.45 14 42923 3793 110542569
Balance disorder 18.71 12.45 11 42926 116549 110429813
Thyroid cancer 18.61 12.45 17 42920 6197 110540165
Pneumoperitoneum 18.39 12.45 14 42923 3970 110542392
Toxicity to various agents 18.35 12.45 275 42662 480280 110066082
Discomfort 18.01 12.45 35 42902 214672 110331690
Loss of personal independence in daily activities 17.98 12.45 19 42918 150001 110396361
Contusion 17.93 12.45 40 42897 233321 110313041
Chills 17.85 12.45 29 42908 190551 110355811
Lethargy 17.81 12.45 7 42930 93569 110452793
Toxic shock syndrome streptococcal 17.52 12.45 6 42931 307 110546055
Vomiting 17.51 12.45 470 42467 910205 109636157
Teething 17.13 12.45 5 42932 151 110546211
Brain empyema 16.95 12.45 4 42933 51 110546311
Vernal keratoconjunctivitis 16.95 12.45 4 42933 51 110546311
Diaphragmatic hernia 16.89 12.45 7 42930 608 110545754
Hypertension 16.87 12.45 285 42652 509799 110036563
Glomerulonephropathy 16.58 12.45 6 42931 361 110546001
Fine motor skill dysfunction 16.55 12.45 16 42921 6258 110540104
Affective disorder 16.36 12.45 21 42916 11220 110535142
Gingival pain 16.34 12.45 25 42912 15711 110530651
Pleural calcification 16.21 12.45 5 42932 183 110546179
Dry skin 16.12 12.45 11 42926 107642 110438720
Metabolic acidosis 16.07 12.45 79 42858 99665 110446697
Thyroid hormones decreased 16.06 12.45 7 42930 688 110545674
Autoimmune disorder 16.02 12.45 3 42934 65480 110480882
Frequent bowel movements 15.98 12.45 4 42933 71386 110474976
Injection site pain 15.81 12.45 28 42909 177894 110368468
Food interaction 15.66 12.45 10 42927 2142 110544220
Nasal disorder 15.53 12.45 13 42924 4221 110542141
Ill-defined disorder 15.52 12.45 23 42914 156830 110389532
Gastroenteropancreatic neuroendocrine tumour disease 15.46 12.45 4 42933 76 110546286
Flushing 15.29 12.45 11 42926 104725 110441637
Insomnia 15.27 12.45 80 42857 360510 110185852
Loss of consciousness 15.13 12.45 129 42808 196177 110350185
Pyrexia 14.88 12.45 455 42482 897810 109648552
Influenza like illness 14.68 12.45 8 42929 88404 110457958
Weight decreased 14.62 12.45 114 42823 467943 110078419
Tongue oedema 14.57 12.45 17 42920 8239 110538123
Pulmonary fibrosis 14.53 12.45 11 42926 102031 110444331
Joint swelling 14.48 12.45 247 42690 442598 110103764
Stomatitis 14.43 12.45 55 42882 270187 110276175
Endothelin increased 14.33 12.45 3 42934 21 110546341
Odontogenic cyst 14.33 12.45 3 42934 21 110546341
Respiratory tract infection 14.23 12.45 5 42932 71612 110474750
Maternal exposure during pregnancy 14.18 12.45 51 42886 254832 110291530
Diarrhoea infectious 14.08 12.45 9 42928 1931 110544431
Mediastinitis 14.01 12.45 8 42929 1400 110544962
Schizophrenia 13.94 12.45 28 42909 21798 110524564
Prostate cancer 13.90 12.45 39 42898 37602 110508760
Arthritis bacterial 13.88 12.45 19 42918 10801 110535561
Fracture displacement 13.68 12.45 8 42929 1464 110544898
Nail disorder 13.45 12.45 3 42934 57932 110488430
Atrial fibrillation 13.41 12.45 45 42892 229597 110316765
Atypical haemolytic uraemic syndrome 13.35 12.45 8 42929 1532 110544830
Infusion related reaction 13.34 12.45 215 42722 380947 110165415
Liver function test increased 13.33 12.45 9 42928 88539 110457823
Osteonecrosis of jaw 13.31 12.45 45 42892 47972 110498390
Mixed anxiety and depressive disorder 13.26 12.45 6 42931 645 110545717
Derealisation 13.21 12.45 9 42928 2149 110544213
Malignant respiratory tract neoplasm 13.21 12.45 3 42934 32 110546330
Chest discomfort 13.19 12.45 30 42907 173818 110372544
Nephritis allergic 13.13 12.45 7 42930 1072 110545290
Staphylococcal sepsis 13.13 12.45 24 42913 17430 110528932
Red blood cell sedimentation rate increased 13.13 12.45 7 42930 78295 110468067
Blood pressure systolic increased 13.08 12.45 8 42929 82983 110463379
Adverse drug reaction 13.07 12.45 13 42924 105546 110440816
Toxic epidermal necrolysis 13.03 12.45 50 42887 56677 110489685
Amnesia 13.03 12.45 13 42924 105395 110440967
Pneumonia 13.02 12.45 251 42686 876463 109669899
Wrong technique in product usage process 12.98 12.45 9 42928 87339 110459023
Hepatic failure 12.95 12.45 57 42880 68682 110477680
Renal vasculitis 12.83 12.45 6 42931 695 110545667
Oedematous pancreatitis 12.82 12.45 8 42929 1646 110544716
Rash pustular 12.79 12.45 20 42917 12809 110533553
Hypercholesterolaemia 12.67 12.45 10 42927 90827 110455535
Allergic colitis 12.66 12.45 3 42934 39 110546323
Peptic ulcer haemorrhage 12.58 12.45 7 42930 1166 110545196
Haematocrit decreased 12.50 12.45 5 42932 66112 110480250
Hepatitis fulminant 12.47 12.45 16 42921 8544 110537818

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M01AE03 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Propionic acid derivatives
ATC M01AE53 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Propionic acid derivatives
ATC M02AA10 MUSCULO-SKELETAL SYSTEM
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Antiinflammatory preparations, non-steroids for topical use
FDA CS M0001335 Anti-Inflammatory Agents, Non-Steroidal
FDA MoA N0000000160 Cyclooxygenase Inhibitors
MeSH PA D000700 Analgesics
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D016861 Cyclooxygenase Inhibitors
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018689 Sensory System Agents
MeSH PA D018712 Analgesics, Non-Narcotic
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35493 antipyretic
CHEBI has role CHEBI:35544 EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:73336 vulnerary
CHEBI has role CHEBI:78298 environmental contaminant
CHEBI has role CHEBI:88188 drug allergen
FDA EPC N0000175722 Nonsteroidal Anti-inflammatory Drug

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Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Pain indication 22253000
Rheumatoid arthritis indication 69896004 DOID:7148
Dysmenorrhea indication 266599000
Osteoarthritis indication 396275006
Ankylosing spondylitis off-label use 9631008 DOID:7147
Gout off-label use 90560007 DOID:13189
Vascular headache off-label use 128187005
Peptic ulcer contraindication 13200003 DOID:750
Myocardial infarction contraindication 22298006 DOID:5844
Hypertensive disorder contraindication 38341003 DOID:10763
Gastrointestinal ulcer contraindication 40845000
Chronic heart failure contraindication 48447003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Hepatic failure contraindication 59927004
Blood coagulation disorder contraindication 64779008 DOID:1247
Gastrointestinal hemorrhage contraindication 74474003
Kidney disease contraindication 90708001 DOID:557
Hypoalbuminemia contraindication 119247004
Coronary artery bypass graft contraindication 232717009
Pregnancy, function contraindication 289908002
Cardiovascular event risk contraindication 395112001
Smokes tobacco daily contraindication 449868002




🐶 Veterinary Drug Use

SpeciesUseRelation
Horses Pain and inflammation associated with musculoskeletal disorders Indication

🐶 Veterinary products

ProductApplicantIngredients
KETOFEN Zoetis Inc. 1
Draxxin KP Zoetis Inc. 2
KetoMed Bimeda Animal Health Limited 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.28 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 6.62 WOMBAT-PK CHEMBL
Prostaglandin G/H synthase 1 Enzyme INHIBITOR IC50 7.33 WOMBAT-PK CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 6.10 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 6.75 CHEMBL
Cyclooxygenase Enzyme IC50 5.47 CHEMBL

External reference:

IDSource
4018064 VUID
N0000146405 NUI
D00132 KEGG_DRUG
4018064 VANDF
C0022635 UMLSCUI
CHEBI:6128 CHEBI
CHEMBL571 ChEMBL_ID
DB01009 DRUGBANK_ID
D007660 MESH_DESCRIPTOR_UI
3825 PUBCHEM_CID
4795 IUPHAR_LIGAND_ID
3284 INN_ID
90Y4QC304K UNII
6142 RXNORM
3365 MMSL
4946 MMSL
d00028 MMSL
002394 NDDF
10099000 SNOMEDCT_US
386832008 SNOMEDCT_US
90Y4QC304K INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 0276-0504 CAPSULE 25 mg ORAL ANDA 23 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 0276-0506 CAPSULE 50 mg ORAL ANDA 23 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 0276-0507 CAPSULE 75 mg ORAL ANDA 23 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 0378-8200 CAPSULE, EXTENDED RELEASE 200 mg ORAL ANDA 28 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 0682-0150 CAPSULE 75 mg ORAL ANDA 23 sections
KETOPROFEN HUMAN PRESCRIPTION DRUG LABEL 1 16590-136 CAPSULE 50 mg ORAL ANDA 28 sections
KETOPROFEN HUMAN PRESCRIPTION DRUG LABEL 1 16590-137 CAPSULE 75 mg ORAL ANDA 28 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 21695-340 CAPSULE 50 mg ORAL ANDA 30 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 21695-341 CAPSULE 75 mg ORAL ANDA 30 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 33261-064 CAPSULE 75 mg ORAL ANDA 28 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 42254-037 CAPSULE 75 mg ORAL ANDA 28 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 45865-379 CAPSULE 75 mg ORAL ANDA 28 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 45865-485 CAPSULE 50 mg ORAL ANDA 28 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 50090-0453 CAPSULE 75 mg ORAL ANDA 28 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 50090-2729 CAPSULE 50 mg ORAL ANDA 28 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 52959-245 CAPSULE 50 mg ORAL ANDA 28 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 53217-221 CAPSULE 50 mg ORAL ANDA 28 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 54868-2414 CAPSULE 50 mg ORAL ANDA 30 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 54868-2415 CAPSULE 75 mg ORAL ANDA 30 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 54868-4826 CAPSULE, EXTENDED RELEASE 200 mg ORAL ANDA 30 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 67296-0369 TABLET 75 mg ORAL ANDA 28 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 85477-111 CAPSULE 50 mg ORAL ANDA 29 sections