ketoprofen ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory agents, ibuprofen derivatives 1528 22071-15-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • RP 19583
  • RP-19583
  • ketoprofen
  • ketoprofene
  • ketoprophen
An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It is used in the treatment of rheumatoid arthritis and osteoarthritis.
  • Molecular weight: 254.29
  • Formula: C16H14O3
  • CLOGP: 2.76
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 54.37
  • ALOGS: -4.08
  • ROTB: 4

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.15 g O
0.15 g P
0.15 g R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.18 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 19.66 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 90 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.13 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.60 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.10 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Jan. 9, 1986 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Temperature regulation disorder 461.13 13.63 133 18426 4094 50582471
Food allergy 379.25 13.63 134 18425 8003 50578562
Coeliac disease 366.98 13.63 133 18426 8552 50578013
Immunodeficiency 314.18 13.63 138 18421 14690 50571875
Bursitis 264.40 13.63 139 18420 21996 50564569
Rash erythematous 222.86 13.63 146 18413 34706 50551859
Fluid retention 153.70 13.63 136 18423 50513 50536052
Erythema 153.31 13.63 226 18333 146188 50440377
Upper respiratory tract infection 139.36 13.63 145 18414 65753 50520812
Acute kidney injury 138.16 13.63 276 18283 227782 50358783
Hyperhidrosis 130.01 13.63 162 18397 89264 50497301
Asthma 126.94 13.63 160 18399 89177 50497388
Constipation 97.40 13.63 212 18347 185496 50401069
Hepatocellular injury 85.36 13.63 73 18486 25874 50560691
Goitre 76.82 13.63 38 18521 5282 50581283
Acute generalised exanthematous pustulosis 76.20 13.63 45 18514 8893 50577672
Rheumatoid arthritis 73.80 13.63 201 18358 202349 50384216
Hepatic enzyme increased 68.74 13.63 154 18405 137226 50449339
Angioedema 65.79 13.63 75 18484 37601 50548964
Face oedema 56.25 13.63 49 18510 17790 50568775
Back pain 52.87 13.63 189 18370 219841 50366724
Peripheral nerve injury 45.38 13.63 13 18546 389 50586176
Hypersensitivity 42.75 13.63 174 18385 214987 50371578
Drug hypersensitivity 42.21 13.63 193 18366 250817 50335748
Poisoning deliberate 40.68 13.63 29 18530 7883 50578682
Hepatic adenoma 40.37 13.63 11 18548 273 50586292
Hepatic cytolysis 40.06 13.63 29 18530 8074 50578491
Lactic acidosis 39.96 13.63 55 18504 33300 50553265
Spinal epidural haemorrhage 39.71 13.63 9 18550 101 50586464
Suicide attempt 39.13 13.63 69 18490 51663 50534902
Cholestasis 38.42 13.63 47 18512 25354 50561211
Pulmonary pain 37.83 13.63 18 18541 2297 50584268
Overdose 37.27 13.63 100 18459 99627 50486938
Alopecia 34.30 13.63 24 18535 245023 50341542
Death 33.64 13.63 42 18517 325337 50261228
Completed suicide 32.07 13.63 5 18554 131884 50454681
Hepatic function abnormal 32.02 13.63 49 18510 32632 50553933
Burning mouth syndrome 31.82 13.63 10 18549 413 50586152
Aspirin-exacerbated respiratory disease 31.80 13.63 12 18547 862 50585703
Gastritis erosive 31.54 13.63 21 18538 5113 50581452
Coma 30.94 13.63 66 18493 56813 50529752
Epidural haemorrhage 28.19 13.63 7 18552 119 50586446
Fine motor skill dysfunction 28.18 13.63 18 18541 4085 50582480
Pneumoperitoneum 27.47 13.63 12 18547 1257 50585308
Systemic lupus erythematosus 26.91 13.63 9 18550 140613 50445952
Anaphylactic shock 26.84 13.63 35 18524 20120 50566445
Toxic skin eruption 26.00 13.63 26 18533 11225 50575340
Melaena 25.92 13.63 40 18519 26824 50559741
Sinoatrial block 25.89 13.63 10 18549 765 50585800
Pneumococcal sepsis 25.81 13.63 9 18550 515 50586050
Glomerulonephropathy 25.39 13.63 6 18553 82 50586483
Hypertransaminasaemia 25.20 13.63 16 18543 3595 50582970
Femoral artery dissection 24.84 13.63 5 18554 30 50586535
Headache 23.89 13.63 287 18272 506248 50080317
Synovitis 23.57 13.63 8 18551 123857 50462708
Drug interaction 23.45 13.63 139 18420 199482 50387083
Nephrolithiasis 23.34 13.63 44 18515 34649 50551916
Inflammation 23.22 13.63 59 18500 56853 50529712
Upper respiratory tract inflammation 22.94 13.63 13 18546 2376 50584189
Epidural analgesia 22.77 13.63 5 18554 48 50586517
Therapeutic product effect decreased 22.30 13.63 11 18548 136039 50450526
Septic shock 22.02 13.63 58 18501 57117 50529448
Foetal heart rate abnormal 21.99 13.63 8 18551 518 50586047
Wound 21.63 13.63 6 18553 105788 50480777
Atypical haemolytic uraemic syndrome 21.55 13.63 8 18551 549 50586016
Duplicate therapy error 21.46 13.63 5 18554 64 50586501
Miosis 21.25 13.63 18 18541 6292 50580273
Mixed anxiety and depressive disorder 21.19 13.63 6 18553 172 50586393
Product dose omission issue 20.84 13.63 22 18537 183816 50402749
Nasal disorder 20.67 13.63 12 18547 2296 50584269
Pancreatitis necrotising 20.53 13.63 10 18549 1343 50585222
Oedematous pancreatitis 20.33 13.63 7 18552 386 50586179
Upper gastrointestinal haemorrhage 20.05 13.63 27 18532 16008 50570557
Product dispensing issue 20.03 13.63 5 18554 87 50586478
Hand deformity 19.90 13.63 6 18553 100193 50486372
Intentional overdose 19.74 13.63 59 18500 62445 50524120
Pancreatitis acute 19.62 13.63 33 18526 23779 50562786
Gastric ulcer 19.55 13.63 31 18528 21274 50565291
Gastroenteropancreatic neuroendocrine tumour disease 19.46 13.63 4 18555 27 50586538
Abdominal discomfort 18.98 13.63 35 18524 231606 50354959
Discomfort 18.95 13.63 8 18551 108372 50478193
Reversible cerebral vasoconstriction syndrome 18.93 13.63 11 18548 2108 50584457
Weight increased 18.87 13.63 28 18531 201863 50384702
Sinusitis 18.68 13.63 21 18538 170537 50416028
Vascular purpura 18.51 13.63 9 18550 1205 50585360
Linear IgA disease 18.23 13.63 9 18550 1245 50585320
Enteritis infectious 17.26 13.63 10 18549 1905 50584660
Toxic epidermal necrolysis 17.17 13.63 29 18530 20963 50565602
Drug intolerance 17.17 13.63 34 18525 219070 50367495
Vanishing bile duct syndrome 17.04 13.63 7 18552 630 50585935
Azotaemia 16.81 13.63 13 18546 3995 50582570
Tubulointerstitial nephritis 16.61 13.63 24 18535 15187 50571378
Pyelonephritis acute 16.60 13.63 13 18546 4070 50582495
Social anxiety disorder 16.40 13.63 6 18553 395 50586170
Inflammatory bowel disease 16.26 13.63 12 18547 3438 50583127
Hepatitis acute 15.88 13.63 17 18542 7944 50578621
Gastric ulcer haemorrhage 15.53 13.63 13 18546 4471 50582094
Blister 15.43 13.63 6 18553 85412 50501153
Thyroid disorder 15.32 13.63 21 18538 12656 50573909
Dermatitis exfoliative generalised 15.02 13.63 11 18548 3115 50583450
Drug level increased 14.95 13.63 26 18533 19242 50567323
Arthritis bacterial 14.87 13.63 14 18545 5615 50580950
Enterocolitis 14.85 13.63 15 18544 6552 50580013
Drug ineffective 14.75 13.63 212 18347 819121 49767444
Renal cortical necrosis 14.61 13.63 4 18555 101 50586464
Intervertebral discitis 14.27 13.63 10 18549 2646 50583919
Maternal exposure during pregnancy 14.12 13.63 23 18536 159755 50426810
Pyelonephritis 14.02 13.63 22 18537 14967 50571598
Musculoskeletal pain 13.99 13.63 58 18501 72119 50514446
Drug abuse 13.97 13.63 51 18508 59795 50526770
Contraindicated product administered 13.95 13.63 98 18461 148860 50437705
Hepatitis cholestatic 13.88 13.63 14 18545 6103 50580462
Spinal compression fracture 13.86 13.63 20 18539 12636 50573929
Mobility decreased 13.82 13.63 6 18553 79942 50506623
Odontogenic cyst 13.64 13.63 3 18556 29 50586536

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 104.02 14.68 259 9904 265008 29299356
Angioedema 90.17 14.68 80 10083 31835 29532529
Anaphylactic shock 62.46 14.68 45 10118 13291 29551073
Lactic acidosis 53.95 14.68 59 10104 30188 29534176
Hepatocellular injury 44.22 14.68 45 10118 21198 29543166
Suicide attempt 43.40 14.68 56 10107 34054 29530310
Poisoning deliberate 43.09 14.68 26 10137 5705 29558659
Death 41.72 14.68 34 10129 342050 29222314
Erythema 40.72 14.68 84 10079 75522 29488842
Acute generalised exanthematous pustulosis 38.58 14.68 24 10139 5559 29558805
Cholestasis 37.10 14.68 43 10120 23419 29540945
Hepatitis cholestatic 36.31 14.68 25 10138 6868 29557496
Myoclonic epilepsy 34.90 14.68 13 10150 962 29563402
Mixed liver injury 34.68 14.68 16 10147 2035 29562329
Pancreatitis acute 34.13 14.68 42 10121 24343 29540021
Vascular purpura 33.65 14.68 14 10149 1389 29562975
Gastric ulcer 33.36 14.68 32 10131 14029 29550335
Palatal oedema 30.83 14.68 11 10152 720 29563644
Enterocolitis 30.08 14.68 22 10141 6644 29557720
Eyelid oedema 29.70 14.68 19 10144 4617 29559747
Tongue oedema 28.40 14.68 15 10148 2551 29561813
Drug interaction 28.09 14.68 138 10025 197247 29367117
Coma 27.58 14.68 49 10114 39401 29524963
Laryngeal discomfort 27.16 14.68 7 10156 149 29564215
Fusobacterium infection 26.65 14.68 6 10157 70 29564294
Blood lactic acid 25.79 14.68 8 10155 338 29564026
Allergy test negative 25.14 14.68 4 10159 4 29564360
Polyneuropathy in malignant disease 24.08 14.68 6 10157 111 29564253
Type I hypersensitivity 23.39 14.68 10 10153 1062 29563302
Intentional overdose 23.34 14.68 45 10118 38483 29525881
Dermatitis bullous 23.33 14.68 18 10145 5888 29558476
Necrotising myositis 23.20 14.68 8 10155 473 29563891
Dyschezia 22.20 14.68 10 10153 1203 29563161
Melaena 22.14 14.68 39 10124 31137 29533227
Anaemia 21.48 14.68 130 10033 200821 29363543
Pruritus 21.31 14.68 88 10075 116761 29447603
Product dose omission issue 20.71 14.68 4 10159 96379 29467985
Altered state of consciousness 19.77 14.68 29 10134 19860 29544504
Liver injury 19.62 14.68 23 10140 12667 29551697
Diarrhoea infectious 19.58 14.68 7 10156 461 29563903
Drug level increased 19.56 14.68 28 10135 18759 29545605
Vitello-intestinal duct remnant 19.42 14.68 5 10158 106 29564258
Vomiting 19.41 14.68 132 10031 212128 29352236
Meningoencephalitis bacterial 18.95 14.68 5 10158 117 29564247
Miosis 18.57 14.68 18 10145 7991 29556373
Hepatic function abnormal 18.10 14.68 41 10122 39218 29525146
Hyperkalaemia 17.90 14.68 54 10109 61338 29503026
Prothrombin time shortened 17.86 14.68 9 10154 1389 29562975
Anterograde amnesia 17.64 14.68 5 10158 154 29564210
Brain empyema 17.32 14.68 3 10160 7 29564357
Gastric ulcer haemorrhage 17.31 14.68 14 10149 4900 29559464
Pallor 17.18 14.68 28 10135 20996 29543368
Fatigue 17.16 14.68 54 10109 316767 29247597
Interstitial lung disease 17.05 14.68 51 10112 57667 29506697
Off label use 16.47 14.68 51 10112 300749 29263615
Pathological fracture 15.78 14.68 12 10151 3843 29560521
Gastric cancer 15.51 14.68 13 10150 4781 29559583
Anaphylactic reaction 15.24 14.68 31 10132 27542 29536822
Metastases to lung 15.18 14.68 16 10147 7839 29556525
Dermatofibrosarcoma protuberans 14.96 14.68 3 10160 19 29564345
Allergic colitis 14.70 14.68 3 10160 21 29564343

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Temperature regulation disorder 440.79 12.28 131 25781 4080 64468740
Coeliac disease 368.00 12.28 131 25781 7281 64465539
Food allergy 364.38 12.28 132 25780 7719 64465101
Immunodeficiency 290.94 12.28 138 25774 15986 64456834
Bursitis 245.17 12.28 135 25777 21350 64451470
Acute kidney injury 204.49 12.28 512 25400 448728 64024092
Erythema 187.24 12.28 297 25615 186773 64286047
Rash erythematous 181.77 12.28 153 25759 48480 64424340
Angioedema 141.30 12.28 148 25764 61673 64411147
Fluid retention 131.42 12.28 140 25772 59466 64413354
Hepatocellular injury 119.24 12.28 117 25795 45118 64427702
Hyperhidrosis 118.90 12.28 194 25718 124726 64348094
Upper respiratory tract infection 115.07 12.28 144 25768 72641 64400179
Asthma 106.05 12.28 159 25753 95066 64377754
Constipation 104.51 12.28 262 25650 229075 64243745
Acute generalised exanthematous pustulosis 97.08 12.28 64 25848 13994 64458826
Lactic acidosis 83.78 12.28 113 25799 61297 64411523
Anaphylactic shock 75.39 12.28 76 25836 30252 64442568
Poisoning deliberate 73.43 12.28 53 25859 13405 64459415
Rheumatoid arthritis 69.89 12.28 183 25729 164111 64308709
Hepatic enzyme increased 68.29 12.28 157 25755 129786 64343034
Death 65.07 12.28 59 25853 482646 63990174
Cholestasis 64.93 12.28 85 25827 44787 64428033
Suicide attempt 63.10 12.28 107 25805 70900 64401920
Hypersensitivity 56.97 12.28 191 25721 196261 64276559
Completed suicide 56.14 12.28 11 25901 224403 64248417
Face oedema 56.03 12.28 59 25853 24702 64448118
Drug hypersensitivity 51.18 12.28 210 25702 237605 64235215
Coma 49.51 12.28 109 25803 87506 64385314
Pancreatitis acute 48.29 12.28 72 25840 42783 64430037
Vascular purpura 46.46 12.28 22 25890 2534 64470286
Hepatitis cholestatic 44.87 12.28 38 25874 12117 64460703
Gastric ulcer 44.87 12.28 58 25854 30176 64442644
Back pain 44.01 12.28 208 25704 249963 64222857
Enterocolitis 43.20 12.28 37 25875 11981 64460839
Pulmonary pain 43.20 12.28 21 25891 2563 64470257
Drug interaction 42.14 12.28 269 25643 361814 64111006
Hepatic cytolysis 40.13 12.28 38 25874 14011 64458809
Hepatic adenoma 39.26 12.28 11 25901 276 64472544
Peripheral nerve injury 38.34 12.28 13 25899 623 64472197
Aspirin-exacerbated respiratory disease 37.54 12.28 15 25897 1145 64471675
Eyelid oedema 36.58 12.28 34 25878 12245 64460575
Overdose 34.36 12.28 141 25771 159425 64313395
Drug level increased 33.69 12.28 54 25858 34142 64438678
Laryngeal discomfort 33.26 12.28 11 25901 488 64472332
Melaena 32.97 12.28 69 25843 53479 64419341
Hepatic function abnormal 32.97 12.28 77 25835 64236 64408584
Goitre 32.78 12.28 22 25890 4951 64467869
Miosis 32.51 12.28 33 25879 13233 64459587
Spinal epidural haemorrhage 30.96 12.28 8 25904 146 64472674
Gastritis erosive 29.42 12.28 27 25885 9568 64463252
Burning mouth syndrome 29.40 12.28 10 25902 484 64472336
Contraindicated product administered 28.74 12.28 102 25810 107727 64365093
Altered state of consciousness 28.36 12.28 53 25859 37849 64434971
Gastric ulcer haemorrhage 27.11 12.28 24 25888 8119 64464701
Foetal heart rate abnormal 26.94 12.28 8 25904 248 64472572
Mixed liver injury 26.34 12.28 20 25892 5461 64467359
Tubulointerstitial nephritis 25.38 12.28 45 25867 30864 64441956
Epidural haemorrhage 25.08 12.28 7 25905 173 64472647
Product dose omission issue 24.77 12.28 25 25887 194722 64278098
Intentional overdose 24.75 12.28 86 25826 89858 64382962
Weight increased 24.28 12.28 30 25882 213318 64259502
Urticaria 24.08 12.28 120 25792 147197 64325623
Palatal oedema 23.91 12.28 11 25901 1186 64471634
Hypertransaminasaemia 23.55 12.28 21 25891 7170 64465650
Fusobacterium infection 23.30 12.28 6 25906 108 64472712
Femoral artery dissection 23.24 12.28 5 25907 39 64472781
Pneumoperitoneum 22.84 12.28 14 25898 2697 64470123
Blood lactic acid 22.28 12.28 8 25904 455 64472365
Epidural analgesia 22.13 12.28 5 25907 50 64472770
Hepatitis acute 21.95 12.28 27 25885 13362 64459458
Polyneuropathy in malignant disease 21.28 12.28 6 25906 154 64472666
Allergy test negative 21.27 12.28 4 25908 14 64472806
Meningoencephalitis bacterial 20.30 12.28 6 25906 183 64472637
Fine motor skill dysfunction 20.09 12.28 16 25896 4683 64468137
Mixed anxiety and depressive disorder 19.99 12.28 6 25906 193 64472627
Toxic skin eruption 19.74 12.28 31 25881 19253 64453567
Vomiting 19.46 12.28 320 25592 550797 63922023
Sinusitis 19.40 12.28 18 25894 145910 64326910
Off label use 19.39 12.28 162 25750 632644 63840176
Product dispensing issue 19.31 12.28 5 25907 92 64472728
Dermatitis bullous 19.26 12.28 24 25888 12030 64460790
Atypical haemolytic uraemic syndrome 19.16 12.28 8 25904 684 64472136
Gastroenteropancreatic neuroendocrine tumour disease 18.73 12.28 4 25908 30 64472790
Tongue oedema 18.65 12.28 17 25895 5973 64466847
Dermatofibrosarcoma protuberans 18.62 12.28 4 25908 31 64472789
Upper respiratory tract inflammation 18.61 12.28 14 25898 3768 64469052
Vitello-intestinal duct remnant 18.47 12.28 5 25907 110 64472710
Intervertebral discitis 18.37 12.28 14 25898 3843 64468977
Cerebrovascular accident 18.26 12.28 17 25895 137566 64335254
Sinoatrial block 18.07 12.28 9 25903 1157 64471663
Mediastinitis 17.95 12.28 8 25904 801 64472019
Hyperkalaemia 17.68 12.28 84 25828 101045 64371775
Fall 17.59 12.28 97 25815 416729 64056091
Rash maculo-papular 17.57 12.28 50 25862 46976 64425844
Glomerulonephropathy 17.57 12.28 6 25906 294 64472526
Hepatitis 17.56 12.28 49 25863 45533 64427287
Dermo-hypodermitis 17.52 12.28 7 25905 534 64472286
Synovitis 17.45 12.28 9 25903 99081 64373739
Oedematous pancreatitis 17.24 12.28 8 25904 880 64471940
Lethargy 17.23 12.28 4 25908 72590 64400230
Necrotising myositis 17.19 12.28 8 25904 886 64471934
Reversible cerebral vasoconstriction syndrome 16.99 12.28 11 25901 2331 64470489
Photosensitivity reaction 16.95 12.28 28 25884 18145 64454675
Anxiety 16.08 12.28 36 25876 202613 64270207
Hyperleukocytosis 15.84 12.28 10 25902 2030 64470790
Duplicate therapy error 15.54 12.28 5 25907 203 64472617
Social anxiety disorder 15.20 12.28 6 25906 444 64472376
Prothrombin time shortened 15.04 12.28 11 25901 2838 64469982
Fracture displacement 15.01 12.28 8 25904 1183 64471637
Nasal disorder 14.92 12.28 11 25901 2873 64469947
Type I hypersensitivity 14.92 12.28 12 25900 3562 64469258
Anaemia 14.90 12.28 224 25688 378456 64094364
Brain empyema 14.78 12.28 3 25909 17 64472803
Lip oedema 14.75 12.28 14 25898 5175 64467645
Metabolic acidosis 14.70 12.28 62 25850 70896 64401924
Septic shock 14.55 12.28 82 25830 105355 64367465
Glossodynia 14.52 12.28 4 25908 64692 64408128
Therapeutic product effect decreased 14.44 12.28 15 25897 115336 64357484
Hepatic failure 14.40 12.28 52 25860 55342 64417478
Odontogenic cyst 14.36 12.28 3 25909 20 64472800
Pneumococcal sepsis 14.33 12.28 8 25904 1296 64471524
Dyschezia 14.32 12.28 10 25902 2400 64470420
Pruritus allergic 14.16 12.28 7 25905 885 64471935
Flushing 14.06 12.28 7 25905 78641 64394179
Prostate cancer 13.96 12.28 27 25885 19768 64453052
Pancreatitis necrotising 13.85 12.28 11 25901 3206 64469614
Allergic colitis 13.77 12.28 3 25909 25 64472795
Colon cancer 13.77 12.28 21 25891 12718 64460102
Meningitis aseptic 13.58 12.28 14 25898 5716 64467104
Endothelin increased 13.56 12.28 3 25909 27 64472793
Femoral neck fracture 13.35 12.28 17 25895 8707 64464113
Chronic obstructive pulmonary disease 13.20 12.28 6 25906 71042 64401778
Chills 12.95 12.28 22 25890 137242 64335578
Drug ineffective 12.95 12.28 249 25663 839998 63632822
Drug intolerance 12.88 12.28 36 25876 187956 64284864
Nasal congestion 12.81 12.28 4 25908 59654 64413166
Dizziness 12.75 12.28 111 25801 430052 64042768
Inflammation 12.72 12.28 56 25856 65244 64407576
Lip pruritus 12.60 12.28 6 25906 699 64472121
Inflammatory bowel disease 12.44 12.28 12 25900 4526 64468294
Pruritus 12.36 12.28 185 25727 312215 64160605
Alpha tumour necrosis factor increased 12.29 12.28 3 25909 43 64472777

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M01AE03 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Propionic acid derivatives
ATC M01AE53 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Propionic acid derivatives
ATC M02AA10 MUSCULO-SKELETAL SYSTEM
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Antiinflammatory preparations, non-steroids for topical use
FDA CS M0001335 Anti-Inflammatory Agents, Non-Steroidal
FDA MoA N0000000160 Cyclooxygenase Inhibitors
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D016861 Cyclooxygenase Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory agent
CHEBI has role CHEBI:35493 anti-pyretic
CHEBI has role CHEBI:35544 cyclooxygenase inhibitors
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:88188 allergenic drug
FDA EPC N0000175722 Nonsteroidal Anti-inflammatory Drug

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Pain indication 22253000
Rheumatoid arthritis indication 69896004 DOID:7148
Dysmenorrhea indication 266599000
Osteoarthritis indication 396275006
Ankylosing spondylitis off-label use 9631008 DOID:7147
Gout off-label use 90560007 DOID:13189
Vascular headache off-label use 128187005
Peptic ulcer contraindication 13200003 DOID:750
Myocardial infarction contraindication 22298006 DOID:5844
Hypertensive disorder contraindication 38341003 DOID:10763
Gastrointestinal ulcer contraindication 40845000
Chronic heart failure contraindication 48447003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Hepatic failure contraindication 59927004
Blood coagulation disorder contraindication 64779008 DOID:1247
Gastrointestinal hemorrhage contraindication 74474003
Kidney disease contraindication 90708001 DOID:557
Hypoalbuminemia contraindication 119247004
Coronary artery bypass graft contraindication 232717009
Pregnancy, function contraindication 289908002
Cardiovascular event risk contraindication 395112001
Smokes tobacco daily contraindication 449868002




๐Ÿถ Veterinary Drug Use

SpeciesUseRelation
Horses Pain and inflammation associated with musculoskeletal disorders Indication

๐Ÿถ Veterinary products

ProductApplicantIngredients
KETOFEN Zoetis Inc. 1
Draxxin KP Zoetis Inc. 2
KetoMed Bimeda Animal Health Limited 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.28 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 6.62 WOMBAT-PK CHEMBL
Prostaglandin G/H synthase 1 Enzyme INHIBITOR IC50 7.33 WOMBAT-PK CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 6.10 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 6.75 CHEMBL
Cyclooxygenase Enzyme IC50 5.47 CHEMBL

External reference:

IDSource
4018064 VUID
N0000146405 NUI
D00132 KEGG_DRUG
4018064 VANDF
C0022635 UMLSCUI
CHEBI:6128 CHEBI
CHEMBL571 ChEMBL_ID
DB01009 DRUGBANK_ID
D007660 MESH_DESCRIPTOR_UI
3825 PUBCHEM_CID
4795 IUPHAR_LIGAND_ID
3284 INN_ID
90Y4QC304K UNII
6142 RXNORM
3365 MMSL
4946 MMSL
d00028 MMSL
002394 NDDF
10099000 SNOMEDCT_US
386832008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 0276-0504 CAPSULE 25 mg ORAL ANDA 23 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 0378-8200 CAPSULE, EXTENDED RELEASE 200 mg ORAL ANDA 29 sections
KETOPROFEN HUMAN PRESCRIPTION DRUG LABEL 1 16590-136 CAPSULE 50 mg ORAL ANDA 28 sections
KETOPROFEN HUMAN PRESCRIPTION DRUG LABEL 1 16590-137 CAPSULE 75 mg ORAL ANDA 28 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 21695-340 CAPSULE 50 mg ORAL ANDA 30 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 21695-341 CAPSULE 75 mg ORAL ANDA 30 sections
ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 23155-020 CAPSULE 25 mg ORAL ANDA 13 sections
ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 23155-021 CAPSULE 50 mg ORAL ANDA 13 sections
ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 23155-022 CAPSULE 75 mg ORAL ANDA 13 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 33261-064 CAPSULE 75 mg ORAL ANDA 28 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 42254-037 CAPSULE 75 mg ORAL ANDA 28 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 45865-379 CAPSULE 75 mg ORAL ANDA 28 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 45865-485 CAPSULE 50 mg ORAL ANDA 28 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 50090-0453 CAPSULE 75 mg ORAL ANDA 28 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 50090-2729 CAPSULE 50 mg ORAL ANDA 28 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 52959-245 CAPSULE 50 mg ORAL ANDA 28 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 53217-221 CAPSULE 50 mg ORAL ANDA 28 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 54868-2414 CAPSULE 50 mg ORAL ANDA 30 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 54868-2415 CAPSULE 75 mg ORAL ANDA 30 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 54868-4826 CAPSULE, EXTENDED RELEASE 200 mg ORAL ANDA 30 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 63187-018 CAPSULE 75 mg ORAL ANDA 28 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 67296-0369 TABLET 75 mg ORAL ANDA 28 sections
Ketoprofen HUMAN PRESCRIPTION DRUG LABEL 1 69336-127 CAPSULE 25 mg ORAL ANDA 14 sections