ketoprofen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| anti-inflammatory agents, ibuprofen derivatives | 1528 | 22071-15-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It is used in the treatment of rheumatoid arthritis and osteoarthritis.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.15 | g | O |
| 0.15 | g | P |
| 0.15 | g | R |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 0.18 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 19.66 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 90 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.13 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 1.60 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.01 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 2.10 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 9, 1986 | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Temperature regulation disorder | 461.13 | 13.63 | 133 | 18426 | 4094 | 50582471 |
| Food allergy | 379.25 | 13.63 | 134 | 18425 | 8003 | 50578562 |
| Coeliac disease | 366.98 | 13.63 | 133 | 18426 | 8552 | 50578013 |
| Immunodeficiency | 314.18 | 13.63 | 138 | 18421 | 14690 | 50571875 |
| Bursitis | 264.40 | 13.63 | 139 | 18420 | 21996 | 50564569 |
| Rash erythematous | 222.86 | 13.63 | 146 | 18413 | 34706 | 50551859 |
| Fluid retention | 153.70 | 13.63 | 136 | 18423 | 50513 | 50536052 |
| Erythema | 153.31 | 13.63 | 226 | 18333 | 146188 | 50440377 |
| Upper respiratory tract infection | 139.36 | 13.63 | 145 | 18414 | 65753 | 50520812 |
| Acute kidney injury | 138.16 | 13.63 | 276 | 18283 | 227782 | 50358783 |
| Hyperhidrosis | 130.01 | 13.63 | 162 | 18397 | 89264 | 50497301 |
| Asthma | 126.94 | 13.63 | 160 | 18399 | 89177 | 50497388 |
| Constipation | 97.40 | 13.63 | 212 | 18347 | 185496 | 50401069 |
| Hepatocellular injury | 85.36 | 13.63 | 73 | 18486 | 25874 | 50560691 |
| Goitre | 76.82 | 13.63 | 38 | 18521 | 5282 | 50581283 |
| Acute generalised exanthematous pustulosis | 76.20 | 13.63 | 45 | 18514 | 8893 | 50577672 |
| Rheumatoid arthritis | 73.80 | 13.63 | 201 | 18358 | 202349 | 50384216 |
| Hepatic enzyme increased | 68.74 | 13.63 | 154 | 18405 | 137226 | 50449339 |
| Angioedema | 65.79 | 13.63 | 75 | 18484 | 37601 | 50548964 |
| Face oedema | 56.25 | 13.63 | 49 | 18510 | 17790 | 50568775 |
| Back pain | 52.87 | 13.63 | 189 | 18370 | 219841 | 50366724 |
| Peripheral nerve injury | 45.38 | 13.63 | 13 | 18546 | 389 | 50586176 |
| Hypersensitivity | 42.75 | 13.63 | 174 | 18385 | 214987 | 50371578 |
| Drug hypersensitivity | 42.21 | 13.63 | 193 | 18366 | 250817 | 50335748 |
| Poisoning deliberate | 40.68 | 13.63 | 29 | 18530 | 7883 | 50578682 |
| Hepatic adenoma | 40.37 | 13.63 | 11 | 18548 | 273 | 50586292 |
| Hepatic cytolysis | 40.06 | 13.63 | 29 | 18530 | 8074 | 50578491 |
| Lactic acidosis | 39.96 | 13.63 | 55 | 18504 | 33300 | 50553265 |
| Spinal epidural haemorrhage | 39.71 | 13.63 | 9 | 18550 | 101 | 50586464 |
| Suicide attempt | 39.13 | 13.63 | 69 | 18490 | 51663 | 50534902 |
| Cholestasis | 38.42 | 13.63 | 47 | 18512 | 25354 | 50561211 |
| Pulmonary pain | 37.83 | 13.63 | 18 | 18541 | 2297 | 50584268 |
| Overdose | 37.27 | 13.63 | 100 | 18459 | 99627 | 50486938 |
| Alopecia | 34.30 | 13.63 | 24 | 18535 | 245023 | 50341542 |
| Death | 33.64 | 13.63 | 42 | 18517 | 325337 | 50261228 |
| Completed suicide | 32.07 | 13.63 | 5 | 18554 | 131884 | 50454681 |
| Hepatic function abnormal | 32.02 | 13.63 | 49 | 18510 | 32632 | 50553933 |
| Burning mouth syndrome | 31.82 | 13.63 | 10 | 18549 | 413 | 50586152 |
| Aspirin-exacerbated respiratory disease | 31.80 | 13.63 | 12 | 18547 | 862 | 50585703 |
| Gastritis erosive | 31.54 | 13.63 | 21 | 18538 | 5113 | 50581452 |
| Coma | 30.94 | 13.63 | 66 | 18493 | 56813 | 50529752 |
| Epidural haemorrhage | 28.19 | 13.63 | 7 | 18552 | 119 | 50586446 |
| Fine motor skill dysfunction | 28.18 | 13.63 | 18 | 18541 | 4085 | 50582480 |
| Pneumoperitoneum | 27.47 | 13.63 | 12 | 18547 | 1257 | 50585308 |
| Systemic lupus erythematosus | 26.91 | 13.63 | 9 | 18550 | 140613 | 50445952 |
| Anaphylactic shock | 26.84 | 13.63 | 35 | 18524 | 20120 | 50566445 |
| Toxic skin eruption | 26.00 | 13.63 | 26 | 18533 | 11225 | 50575340 |
| Melaena | 25.92 | 13.63 | 40 | 18519 | 26824 | 50559741 |
| Sinoatrial block | 25.89 | 13.63 | 10 | 18549 | 765 | 50585800 |
| Pneumococcal sepsis | 25.81 | 13.63 | 9 | 18550 | 515 | 50586050 |
| Glomerulonephropathy | 25.39 | 13.63 | 6 | 18553 | 82 | 50586483 |
| Hypertransaminasaemia | 25.20 | 13.63 | 16 | 18543 | 3595 | 50582970 |
| Femoral artery dissection | 24.84 | 13.63 | 5 | 18554 | 30 | 50586535 |
| Headache | 23.89 | 13.63 | 287 | 18272 | 506248 | 50080317 |
| Synovitis | 23.57 | 13.63 | 8 | 18551 | 123857 | 50462708 |
| Drug interaction | 23.45 | 13.63 | 139 | 18420 | 199482 | 50387083 |
| Nephrolithiasis | 23.34 | 13.63 | 44 | 18515 | 34649 | 50551916 |
| Inflammation | 23.22 | 13.63 | 59 | 18500 | 56853 | 50529712 |
| Upper respiratory tract inflammation | 22.94 | 13.63 | 13 | 18546 | 2376 | 50584189 |
| Epidural analgesia | 22.77 | 13.63 | 5 | 18554 | 48 | 50586517 |
| Therapeutic product effect decreased | 22.30 | 13.63 | 11 | 18548 | 136039 | 50450526 |
| Septic shock | 22.02 | 13.63 | 58 | 18501 | 57117 | 50529448 |
| Foetal heart rate abnormal | 21.99 | 13.63 | 8 | 18551 | 518 | 50586047 |
| Wound | 21.63 | 13.63 | 6 | 18553 | 105788 | 50480777 |
| Atypical haemolytic uraemic syndrome | 21.55 | 13.63 | 8 | 18551 | 549 | 50586016 |
| Duplicate therapy error | 21.46 | 13.63 | 5 | 18554 | 64 | 50586501 |
| Miosis | 21.25 | 13.63 | 18 | 18541 | 6292 | 50580273 |
| Mixed anxiety and depressive disorder | 21.19 | 13.63 | 6 | 18553 | 172 | 50586393 |
| Product dose omission issue | 20.84 | 13.63 | 22 | 18537 | 183816 | 50402749 |
| Nasal disorder | 20.67 | 13.63 | 12 | 18547 | 2296 | 50584269 |
| Pancreatitis necrotising | 20.53 | 13.63 | 10 | 18549 | 1343 | 50585222 |
| Oedematous pancreatitis | 20.33 | 13.63 | 7 | 18552 | 386 | 50586179 |
| Upper gastrointestinal haemorrhage | 20.05 | 13.63 | 27 | 18532 | 16008 | 50570557 |
| Product dispensing issue | 20.03 | 13.63 | 5 | 18554 | 87 | 50586478 |
| Hand deformity | 19.90 | 13.63 | 6 | 18553 | 100193 | 50486372 |
| Intentional overdose | 19.74 | 13.63 | 59 | 18500 | 62445 | 50524120 |
| Pancreatitis acute | 19.62 | 13.63 | 33 | 18526 | 23779 | 50562786 |
| Gastric ulcer | 19.55 | 13.63 | 31 | 18528 | 21274 | 50565291 |
| Gastroenteropancreatic neuroendocrine tumour disease | 19.46 | 13.63 | 4 | 18555 | 27 | 50586538 |
| Abdominal discomfort | 18.98 | 13.63 | 35 | 18524 | 231606 | 50354959 |
| Discomfort | 18.95 | 13.63 | 8 | 18551 | 108372 | 50478193 |
| Reversible cerebral vasoconstriction syndrome | 18.93 | 13.63 | 11 | 18548 | 2108 | 50584457 |
| Weight increased | 18.87 | 13.63 | 28 | 18531 | 201863 | 50384702 |
| Sinusitis | 18.68 | 13.63 | 21 | 18538 | 170537 | 50416028 |
| Vascular purpura | 18.51 | 13.63 | 9 | 18550 | 1205 | 50585360 |
| Linear IgA disease | 18.23 | 13.63 | 9 | 18550 | 1245 | 50585320 |
| Enteritis infectious | 17.26 | 13.63 | 10 | 18549 | 1905 | 50584660 |
| Toxic epidermal necrolysis | 17.17 | 13.63 | 29 | 18530 | 20963 | 50565602 |
| Drug intolerance | 17.17 | 13.63 | 34 | 18525 | 219070 | 50367495 |
| Vanishing bile duct syndrome | 17.04 | 13.63 | 7 | 18552 | 630 | 50585935 |
| Azotaemia | 16.81 | 13.63 | 13 | 18546 | 3995 | 50582570 |
| Tubulointerstitial nephritis | 16.61 | 13.63 | 24 | 18535 | 15187 | 50571378 |
| Pyelonephritis acute | 16.60 | 13.63 | 13 | 18546 | 4070 | 50582495 |
| Social anxiety disorder | 16.40 | 13.63 | 6 | 18553 | 395 | 50586170 |
| Inflammatory bowel disease | 16.26 | 13.63 | 12 | 18547 | 3438 | 50583127 |
| Hepatitis acute | 15.88 | 13.63 | 17 | 18542 | 7944 | 50578621 |
| Gastric ulcer haemorrhage | 15.53 | 13.63 | 13 | 18546 | 4471 | 50582094 |
| Blister | 15.43 | 13.63 | 6 | 18553 | 85412 | 50501153 |
| Thyroid disorder | 15.32 | 13.63 | 21 | 18538 | 12656 | 50573909 |
| Dermatitis exfoliative generalised | 15.02 | 13.63 | 11 | 18548 | 3115 | 50583450 |
| Drug level increased | 14.95 | 13.63 | 26 | 18533 | 19242 | 50567323 |
| Arthritis bacterial | 14.87 | 13.63 | 14 | 18545 | 5615 | 50580950 |
| Enterocolitis | 14.85 | 13.63 | 15 | 18544 | 6552 | 50580013 |
| Drug ineffective | 14.75 | 13.63 | 212 | 18347 | 819121 | 49767444 |
| Renal cortical necrosis | 14.61 | 13.63 | 4 | 18555 | 101 | 50586464 |
| Intervertebral discitis | 14.27 | 13.63 | 10 | 18549 | 2646 | 50583919 |
| Maternal exposure during pregnancy | 14.12 | 13.63 | 23 | 18536 | 159755 | 50426810 |
| Pyelonephritis | 14.02 | 13.63 | 22 | 18537 | 14967 | 50571598 |
| Musculoskeletal pain | 13.99 | 13.63 | 58 | 18501 | 72119 | 50514446 |
| Drug abuse | 13.97 | 13.63 | 51 | 18508 | 59795 | 50526770 |
| Contraindicated product administered | 13.95 | 13.63 | 98 | 18461 | 148860 | 50437705 |
| Hepatitis cholestatic | 13.88 | 13.63 | 14 | 18545 | 6103 | 50580462 |
| Spinal compression fracture | 13.86 | 13.63 | 20 | 18539 | 12636 | 50573929 |
| Mobility decreased | 13.82 | 13.63 | 6 | 18553 | 79942 | 50506623 |
| Odontogenic cyst | 13.64 | 13.63 | 3 | 18556 | 29 | 50586536 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Acute kidney injury | 104.02 | 14.68 | 259 | 9904 | 265008 | 29299356 |
| Angioedema | 90.17 | 14.68 | 80 | 10083 | 31835 | 29532529 |
| Anaphylactic shock | 62.46 | 14.68 | 45 | 10118 | 13291 | 29551073 |
| Lactic acidosis | 53.95 | 14.68 | 59 | 10104 | 30188 | 29534176 |
| Hepatocellular injury | 44.22 | 14.68 | 45 | 10118 | 21198 | 29543166 |
| Suicide attempt | 43.40 | 14.68 | 56 | 10107 | 34054 | 29530310 |
| Poisoning deliberate | 43.09 | 14.68 | 26 | 10137 | 5705 | 29558659 |
| Death | 41.72 | 14.68 | 34 | 10129 | 342050 | 29222314 |
| Erythema | 40.72 | 14.68 | 84 | 10079 | 75522 | 29488842 |
| Acute generalised exanthematous pustulosis | 38.58 | 14.68 | 24 | 10139 | 5559 | 29558805 |
| Cholestasis | 37.10 | 14.68 | 43 | 10120 | 23419 | 29540945 |
| Hepatitis cholestatic | 36.31 | 14.68 | 25 | 10138 | 6868 | 29557496 |
| Myoclonic epilepsy | 34.90 | 14.68 | 13 | 10150 | 962 | 29563402 |
| Mixed liver injury | 34.68 | 14.68 | 16 | 10147 | 2035 | 29562329 |
| Pancreatitis acute | 34.13 | 14.68 | 42 | 10121 | 24343 | 29540021 |
| Vascular purpura | 33.65 | 14.68 | 14 | 10149 | 1389 | 29562975 |
| Gastric ulcer | 33.36 | 14.68 | 32 | 10131 | 14029 | 29550335 |
| Palatal oedema | 30.83 | 14.68 | 11 | 10152 | 720 | 29563644 |
| Enterocolitis | 30.08 | 14.68 | 22 | 10141 | 6644 | 29557720 |
| Eyelid oedema | 29.70 | 14.68 | 19 | 10144 | 4617 | 29559747 |
| Tongue oedema | 28.40 | 14.68 | 15 | 10148 | 2551 | 29561813 |
| Drug interaction | 28.09 | 14.68 | 138 | 10025 | 197247 | 29367117 |
| Coma | 27.58 | 14.68 | 49 | 10114 | 39401 | 29524963 |
| Laryngeal discomfort | 27.16 | 14.68 | 7 | 10156 | 149 | 29564215 |
| Fusobacterium infection | 26.65 | 14.68 | 6 | 10157 | 70 | 29564294 |
| Blood lactic acid | 25.79 | 14.68 | 8 | 10155 | 338 | 29564026 |
| Allergy test negative | 25.14 | 14.68 | 4 | 10159 | 4 | 29564360 |
| Polyneuropathy in malignant disease | 24.08 | 14.68 | 6 | 10157 | 111 | 29564253 |
| Type I hypersensitivity | 23.39 | 14.68 | 10 | 10153 | 1062 | 29563302 |
| Intentional overdose | 23.34 | 14.68 | 45 | 10118 | 38483 | 29525881 |
| Dermatitis bullous | 23.33 | 14.68 | 18 | 10145 | 5888 | 29558476 |
| Necrotising myositis | 23.20 | 14.68 | 8 | 10155 | 473 | 29563891 |
| Dyschezia | 22.20 | 14.68 | 10 | 10153 | 1203 | 29563161 |
| Melaena | 22.14 | 14.68 | 39 | 10124 | 31137 | 29533227 |
| Anaemia | 21.48 | 14.68 | 130 | 10033 | 200821 | 29363543 |
| Pruritus | 21.31 | 14.68 | 88 | 10075 | 116761 | 29447603 |
| Product dose omission issue | 20.71 | 14.68 | 4 | 10159 | 96379 | 29467985 |
| Altered state of consciousness | 19.77 | 14.68 | 29 | 10134 | 19860 | 29544504 |
| Liver injury | 19.62 | 14.68 | 23 | 10140 | 12667 | 29551697 |
| Diarrhoea infectious | 19.58 | 14.68 | 7 | 10156 | 461 | 29563903 |
| Drug level increased | 19.56 | 14.68 | 28 | 10135 | 18759 | 29545605 |
| Vitello-intestinal duct remnant | 19.42 | 14.68 | 5 | 10158 | 106 | 29564258 |
| Vomiting | 19.41 | 14.68 | 132 | 10031 | 212128 | 29352236 |
| Meningoencephalitis bacterial | 18.95 | 14.68 | 5 | 10158 | 117 | 29564247 |
| Miosis | 18.57 | 14.68 | 18 | 10145 | 7991 | 29556373 |
| Hepatic function abnormal | 18.10 | 14.68 | 41 | 10122 | 39218 | 29525146 |
| Hyperkalaemia | 17.90 | 14.68 | 54 | 10109 | 61338 | 29503026 |
| Prothrombin time shortened | 17.86 | 14.68 | 9 | 10154 | 1389 | 29562975 |
| Anterograde amnesia | 17.64 | 14.68 | 5 | 10158 | 154 | 29564210 |
| Brain empyema | 17.32 | 14.68 | 3 | 10160 | 7 | 29564357 |
| Gastric ulcer haemorrhage | 17.31 | 14.68 | 14 | 10149 | 4900 | 29559464 |
| Pallor | 17.18 | 14.68 | 28 | 10135 | 20996 | 29543368 |
| Fatigue | 17.16 | 14.68 | 54 | 10109 | 316767 | 29247597 |
| Interstitial lung disease | 17.05 | 14.68 | 51 | 10112 | 57667 | 29506697 |
| Off label use | 16.47 | 14.68 | 51 | 10112 | 300749 | 29263615 |
| Pathological fracture | 15.78 | 14.68 | 12 | 10151 | 3843 | 29560521 |
| Gastric cancer | 15.51 | 14.68 | 13 | 10150 | 4781 | 29559583 |
| Anaphylactic reaction | 15.24 | 14.68 | 31 | 10132 | 27542 | 29536822 |
| Metastases to lung | 15.18 | 14.68 | 16 | 10147 | 7839 | 29556525 |
| Dermatofibrosarcoma protuberans | 14.96 | 14.68 | 3 | 10160 | 19 | 29564345 |
| Allergic colitis | 14.70 | 14.68 | 3 | 10160 | 21 | 29564343 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Temperature regulation disorder | 440.79 | 12.28 | 131 | 25781 | 4080 | 64468740 |
| Coeliac disease | 368.00 | 12.28 | 131 | 25781 | 7281 | 64465539 |
| Food allergy | 364.38 | 12.28 | 132 | 25780 | 7719 | 64465101 |
| Immunodeficiency | 290.94 | 12.28 | 138 | 25774 | 15986 | 64456834 |
| Bursitis | 245.17 | 12.28 | 135 | 25777 | 21350 | 64451470 |
| Acute kidney injury | 204.49 | 12.28 | 512 | 25400 | 448728 | 64024092 |
| Erythema | 187.24 | 12.28 | 297 | 25615 | 186773 | 64286047 |
| Rash erythematous | 181.77 | 12.28 | 153 | 25759 | 48480 | 64424340 |
| Angioedema | 141.30 | 12.28 | 148 | 25764 | 61673 | 64411147 |
| Fluid retention | 131.42 | 12.28 | 140 | 25772 | 59466 | 64413354 |
| Hepatocellular injury | 119.24 | 12.28 | 117 | 25795 | 45118 | 64427702 |
| Hyperhidrosis | 118.90 | 12.28 | 194 | 25718 | 124726 | 64348094 |
| Upper respiratory tract infection | 115.07 | 12.28 | 144 | 25768 | 72641 | 64400179 |
| Asthma | 106.05 | 12.28 | 159 | 25753 | 95066 | 64377754 |
| Constipation | 104.51 | 12.28 | 262 | 25650 | 229075 | 64243745 |
| Acute generalised exanthematous pustulosis | 97.08 | 12.28 | 64 | 25848 | 13994 | 64458826 |
| Lactic acidosis | 83.78 | 12.28 | 113 | 25799 | 61297 | 64411523 |
| Anaphylactic shock | 75.39 | 12.28 | 76 | 25836 | 30252 | 64442568 |
| Poisoning deliberate | 73.43 | 12.28 | 53 | 25859 | 13405 | 64459415 |
| Rheumatoid arthritis | 69.89 | 12.28 | 183 | 25729 | 164111 | 64308709 |
| Hepatic enzyme increased | 68.29 | 12.28 | 157 | 25755 | 129786 | 64343034 |
| Death | 65.07 | 12.28 | 59 | 25853 | 482646 | 63990174 |
| Cholestasis | 64.93 | 12.28 | 85 | 25827 | 44787 | 64428033 |
| Suicide attempt | 63.10 | 12.28 | 107 | 25805 | 70900 | 64401920 |
| Hypersensitivity | 56.97 | 12.28 | 191 | 25721 | 196261 | 64276559 |
| Completed suicide | 56.14 | 12.28 | 11 | 25901 | 224403 | 64248417 |
| Face oedema | 56.03 | 12.28 | 59 | 25853 | 24702 | 64448118 |
| Drug hypersensitivity | 51.18 | 12.28 | 210 | 25702 | 237605 | 64235215 |
| Coma | 49.51 | 12.28 | 109 | 25803 | 87506 | 64385314 |
| Pancreatitis acute | 48.29 | 12.28 | 72 | 25840 | 42783 | 64430037 |
| Vascular purpura | 46.46 | 12.28 | 22 | 25890 | 2534 | 64470286 |
| Hepatitis cholestatic | 44.87 | 12.28 | 38 | 25874 | 12117 | 64460703 |
| Gastric ulcer | 44.87 | 12.28 | 58 | 25854 | 30176 | 64442644 |
| Back pain | 44.01 | 12.28 | 208 | 25704 | 249963 | 64222857 |
| Enterocolitis | 43.20 | 12.28 | 37 | 25875 | 11981 | 64460839 |
| Pulmonary pain | 43.20 | 12.28 | 21 | 25891 | 2563 | 64470257 |
| Drug interaction | 42.14 | 12.28 | 269 | 25643 | 361814 | 64111006 |
| Hepatic cytolysis | 40.13 | 12.28 | 38 | 25874 | 14011 | 64458809 |
| Hepatic adenoma | 39.26 | 12.28 | 11 | 25901 | 276 | 64472544 |
| Peripheral nerve injury | 38.34 | 12.28 | 13 | 25899 | 623 | 64472197 |
| Aspirin-exacerbated respiratory disease | 37.54 | 12.28 | 15 | 25897 | 1145 | 64471675 |
| Eyelid oedema | 36.58 | 12.28 | 34 | 25878 | 12245 | 64460575 |
| Overdose | 34.36 | 12.28 | 141 | 25771 | 159425 | 64313395 |
| Drug level increased | 33.69 | 12.28 | 54 | 25858 | 34142 | 64438678 |
| Laryngeal discomfort | 33.26 | 12.28 | 11 | 25901 | 488 | 64472332 |
| Melaena | 32.97 | 12.28 | 69 | 25843 | 53479 | 64419341 |
| Hepatic function abnormal | 32.97 | 12.28 | 77 | 25835 | 64236 | 64408584 |
| Goitre | 32.78 | 12.28 | 22 | 25890 | 4951 | 64467869 |
| Miosis | 32.51 | 12.28 | 33 | 25879 | 13233 | 64459587 |
| Spinal epidural haemorrhage | 30.96 | 12.28 | 8 | 25904 | 146 | 64472674 |
| Gastritis erosive | 29.42 | 12.28 | 27 | 25885 | 9568 | 64463252 |
| Burning mouth syndrome | 29.40 | 12.28 | 10 | 25902 | 484 | 64472336 |
| Contraindicated product administered | 28.74 | 12.28 | 102 | 25810 | 107727 | 64365093 |
| Altered state of consciousness | 28.36 | 12.28 | 53 | 25859 | 37849 | 64434971 |
| Gastric ulcer haemorrhage | 27.11 | 12.28 | 24 | 25888 | 8119 | 64464701 |
| Foetal heart rate abnormal | 26.94 | 12.28 | 8 | 25904 | 248 | 64472572 |
| Mixed liver injury | 26.34 | 12.28 | 20 | 25892 | 5461 | 64467359 |
| Tubulointerstitial nephritis | 25.38 | 12.28 | 45 | 25867 | 30864 | 64441956 |
| Epidural haemorrhage | 25.08 | 12.28 | 7 | 25905 | 173 | 64472647 |
| Product dose omission issue | 24.77 | 12.28 | 25 | 25887 | 194722 | 64278098 |
| Intentional overdose | 24.75 | 12.28 | 86 | 25826 | 89858 | 64382962 |
| Weight increased | 24.28 | 12.28 | 30 | 25882 | 213318 | 64259502 |
| Urticaria | 24.08 | 12.28 | 120 | 25792 | 147197 | 64325623 |
| Palatal oedema | 23.91 | 12.28 | 11 | 25901 | 1186 | 64471634 |
| Hypertransaminasaemia | 23.55 | 12.28 | 21 | 25891 | 7170 | 64465650 |
| Fusobacterium infection | 23.30 | 12.28 | 6 | 25906 | 108 | 64472712 |
| Femoral artery dissection | 23.24 | 12.28 | 5 | 25907 | 39 | 64472781 |
| Pneumoperitoneum | 22.84 | 12.28 | 14 | 25898 | 2697 | 64470123 |
| Blood lactic acid | 22.28 | 12.28 | 8 | 25904 | 455 | 64472365 |
| Epidural analgesia | 22.13 | 12.28 | 5 | 25907 | 50 | 64472770 |
| Hepatitis acute | 21.95 | 12.28 | 27 | 25885 | 13362 | 64459458 |
| Polyneuropathy in malignant disease | 21.28 | 12.28 | 6 | 25906 | 154 | 64472666 |
| Allergy test negative | 21.27 | 12.28 | 4 | 25908 | 14 | 64472806 |
| Meningoencephalitis bacterial | 20.30 | 12.28 | 6 | 25906 | 183 | 64472637 |
| Fine motor skill dysfunction | 20.09 | 12.28 | 16 | 25896 | 4683 | 64468137 |
| Mixed anxiety and depressive disorder | 19.99 | 12.28 | 6 | 25906 | 193 | 64472627 |
| Toxic skin eruption | 19.74 | 12.28 | 31 | 25881 | 19253 | 64453567 |
| Vomiting | 19.46 | 12.28 | 320 | 25592 | 550797 | 63922023 |
| Sinusitis | 19.40 | 12.28 | 18 | 25894 | 145910 | 64326910 |
| Off label use | 19.39 | 12.28 | 162 | 25750 | 632644 | 63840176 |
| Product dispensing issue | 19.31 | 12.28 | 5 | 25907 | 92 | 64472728 |
| Dermatitis bullous | 19.26 | 12.28 | 24 | 25888 | 12030 | 64460790 |
| Atypical haemolytic uraemic syndrome | 19.16 | 12.28 | 8 | 25904 | 684 | 64472136 |
| Gastroenteropancreatic neuroendocrine tumour disease | 18.73 | 12.28 | 4 | 25908 | 30 | 64472790 |
| Tongue oedema | 18.65 | 12.28 | 17 | 25895 | 5973 | 64466847 |
| Dermatofibrosarcoma protuberans | 18.62 | 12.28 | 4 | 25908 | 31 | 64472789 |
| Upper respiratory tract inflammation | 18.61 | 12.28 | 14 | 25898 | 3768 | 64469052 |
| Vitello-intestinal duct remnant | 18.47 | 12.28 | 5 | 25907 | 110 | 64472710 |
| Intervertebral discitis | 18.37 | 12.28 | 14 | 25898 | 3843 | 64468977 |
| Cerebrovascular accident | 18.26 | 12.28 | 17 | 25895 | 137566 | 64335254 |
| Sinoatrial block | 18.07 | 12.28 | 9 | 25903 | 1157 | 64471663 |
| Mediastinitis | 17.95 | 12.28 | 8 | 25904 | 801 | 64472019 |
| Hyperkalaemia | 17.68 | 12.28 | 84 | 25828 | 101045 | 64371775 |
| Fall | 17.59 | 12.28 | 97 | 25815 | 416729 | 64056091 |
| Rash maculo-papular | 17.57 | 12.28 | 50 | 25862 | 46976 | 64425844 |
| Glomerulonephropathy | 17.57 | 12.28 | 6 | 25906 | 294 | 64472526 |
| Hepatitis | 17.56 | 12.28 | 49 | 25863 | 45533 | 64427287 |
| Dermo-hypodermitis | 17.52 | 12.28 | 7 | 25905 | 534 | 64472286 |
| Synovitis | 17.45 | 12.28 | 9 | 25903 | 99081 | 64373739 |
| Oedematous pancreatitis | 17.24 | 12.28 | 8 | 25904 | 880 | 64471940 |
| Lethargy | 17.23 | 12.28 | 4 | 25908 | 72590 | 64400230 |
| Necrotising myositis | 17.19 | 12.28 | 8 | 25904 | 886 | 64471934 |
| Reversible cerebral vasoconstriction syndrome | 16.99 | 12.28 | 11 | 25901 | 2331 | 64470489 |
| Photosensitivity reaction | 16.95 | 12.28 | 28 | 25884 | 18145 | 64454675 |
| Anxiety | 16.08 | 12.28 | 36 | 25876 | 202613 | 64270207 |
| Hyperleukocytosis | 15.84 | 12.28 | 10 | 25902 | 2030 | 64470790 |
| Duplicate therapy error | 15.54 | 12.28 | 5 | 25907 | 203 | 64472617 |
| Social anxiety disorder | 15.20 | 12.28 | 6 | 25906 | 444 | 64472376 |
| Prothrombin time shortened | 15.04 | 12.28 | 11 | 25901 | 2838 | 64469982 |
| Fracture displacement | 15.01 | 12.28 | 8 | 25904 | 1183 | 64471637 |
| Nasal disorder | 14.92 | 12.28 | 11 | 25901 | 2873 | 64469947 |
| Type I hypersensitivity | 14.92 | 12.28 | 12 | 25900 | 3562 | 64469258 |
| Anaemia | 14.90 | 12.28 | 224 | 25688 | 378456 | 64094364 |
| Brain empyema | 14.78 | 12.28 | 3 | 25909 | 17 | 64472803 |
| Lip oedema | 14.75 | 12.28 | 14 | 25898 | 5175 | 64467645 |
| Metabolic acidosis | 14.70 | 12.28 | 62 | 25850 | 70896 | 64401924 |
| Septic shock | 14.55 | 12.28 | 82 | 25830 | 105355 | 64367465 |
| Glossodynia | 14.52 | 12.28 | 4 | 25908 | 64692 | 64408128 |
| Therapeutic product effect decreased | 14.44 | 12.28 | 15 | 25897 | 115336 | 64357484 |
| Hepatic failure | 14.40 | 12.28 | 52 | 25860 | 55342 | 64417478 |
| Odontogenic cyst | 14.36 | 12.28 | 3 | 25909 | 20 | 64472800 |
| Pneumococcal sepsis | 14.33 | 12.28 | 8 | 25904 | 1296 | 64471524 |
| Dyschezia | 14.32 | 12.28 | 10 | 25902 | 2400 | 64470420 |
| Pruritus allergic | 14.16 | 12.28 | 7 | 25905 | 885 | 64471935 |
| Flushing | 14.06 | 12.28 | 7 | 25905 | 78641 | 64394179 |
| Prostate cancer | 13.96 | 12.28 | 27 | 25885 | 19768 | 64453052 |
| Pancreatitis necrotising | 13.85 | 12.28 | 11 | 25901 | 3206 | 64469614 |
| Allergic colitis | 13.77 | 12.28 | 3 | 25909 | 25 | 64472795 |
| Colon cancer | 13.77 | 12.28 | 21 | 25891 | 12718 | 64460102 |
| Meningitis aseptic | 13.58 | 12.28 | 14 | 25898 | 5716 | 64467104 |
| Endothelin increased | 13.56 | 12.28 | 3 | 25909 | 27 | 64472793 |
| Femoral neck fracture | 13.35 | 12.28 | 17 | 25895 | 8707 | 64464113 |
| Chronic obstructive pulmonary disease | 13.20 | 12.28 | 6 | 25906 | 71042 | 64401778 |
| Chills | 12.95 | 12.28 | 22 | 25890 | 137242 | 64335578 |
| Drug ineffective | 12.95 | 12.28 | 249 | 25663 | 839998 | 63632822 |
| Drug intolerance | 12.88 | 12.28 | 36 | 25876 | 187956 | 64284864 |
| Nasal congestion | 12.81 | 12.28 | 4 | 25908 | 59654 | 64413166 |
| Dizziness | 12.75 | 12.28 | 111 | 25801 | 430052 | 64042768 |
| Inflammation | 12.72 | 12.28 | 56 | 25856 | 65244 | 64407576 |
| Lip pruritus | 12.60 | 12.28 | 6 | 25906 | 699 | 64472121 |
| Inflammatory bowel disease | 12.44 | 12.28 | 12 | 25900 | 4526 | 64468294 |
| Pruritus | 12.36 | 12.28 | 185 | 25727 | 312215 | 64160605 |
| Alpha tumour necrosis factor increased | 12.29 | 12.28 | 3 | 25909 | 43 | 64472777 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | M01AE03 | MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Propionic acid derivatives |
| ATC | M01AE53 | MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Propionic acid derivatives |
| ATC | M02AA10 | MUSCULO-SKELETAL SYSTEM TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN Antiinflammatory preparations, non-steroids for topical use |
| FDA CS | M0001335 | Anti-Inflammatory Agents, Non-Steroidal |
| FDA MoA | N0000000160 | Cyclooxygenase Inhibitors |
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D018712 | Analgesics, Non-Narcotic |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D000894 | Anti-Inflammatory Agents, Non-Steroidal |
| MeSH PA | D018501 | Antirheumatic Agents |
| MeSH PA | D016861 | Cyclooxygenase Inhibitors |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D018689 | Sensory System Agents |
| CHEBI has role | CHEBI:35475 | non-steroidal anti-inflammatory agent |
| CHEBI has role | CHEBI:35493 | anti-pyretic |
| CHEBI has role | CHEBI:35544 | cyclooxygenase inhibitors |
| CHEBI has role | CHEBI:35703 | Xenobiotic |
| CHEBI has role | CHEBI:78298 | environmental contaminants |
| CHEBI has role | CHEBI:88188 | allergenic drug |
| FDA EPC | N0000175722 | Nonsteroidal Anti-inflammatory Drug |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Pain | indication | 22253000 | |
| Rheumatoid arthritis | indication | 69896004 | DOID:7148 |
| Dysmenorrhea | indication | 266599000 | |
| Osteoarthritis | indication | 396275006 | |
| Ankylosing spondylitis | off-label use | 9631008 | DOID:7147 |
| Gout | off-label use | 90560007 | DOID:13189 |
| Vascular headache | off-label use | 128187005 | |
| Peptic ulcer | contraindication | 13200003 | DOID:750 |
| Myocardial infarction | contraindication | 22298006 | DOID:5844 |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Gastrointestinal ulcer | contraindication | 40845000 | |
| Chronic heart failure | contraindication | 48447003 | |
| Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
| Hepatic failure | contraindication | 59927004 | |
| Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
| Gastrointestinal hemorrhage | contraindication | 74474003 | |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Hypoalbuminemia | contraindication | 119247004 | |
| Coronary artery bypass graft | contraindication | 232717009 | |
| Pregnancy, function | contraindication | 289908002 | |
| Cardiovascular event risk | contraindication | 395112001 | |
| Smokes tobacco daily | contraindication | 449868002 |
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Horses | Pain and inflammation associated with musculoskeletal disorders | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| KETOFEN | Zoetis Inc. | 1 |
| Draxxin KP | Zoetis Inc. | 2 |
| KetoMed | Bimeda Animal Health Limited | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.28 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Prostaglandin G/H synthase 2 | Enzyme | INHIBITOR | IC50 | 6.62 | WOMBAT-PK | CHEMBL | |||
| Prostaglandin G/H synthase 1 | Enzyme | INHIBITOR | IC50 | 7.33 | WOMBAT-PK | CHEMBL | |||
| Prostaglandin G/H synthase 1 | Enzyme | IC50 | 6.10 | CHEMBL | |||||
| Prostaglandin G/H synthase 2 | Enzyme | IC50 | 6.75 | CHEMBL | |||||
| Cyclooxygenase | Enzyme | IC50 | 5.47 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4018064 | VUID |
| N0000146405 | NUI |
| D00132 | KEGG_DRUG |
| 4018064 | VANDF |
| C0022635 | UMLSCUI |
| CHEBI:6128 | CHEBI |
| CHEMBL571 | ChEMBL_ID |
| DB01009 | DRUGBANK_ID |
| D007660 | MESH_DESCRIPTOR_UI |
| 3825 | PUBCHEM_CID |
| 4795 | IUPHAR_LIGAND_ID |
| 3284 | INN_ID |
| 90Y4QC304K | UNII |
| 6142 | RXNORM |
| 3365 | MMSL |
| 4946 | MMSL |
| d00028 | MMSL |
| 002394 | NDDF |
| 10099000 | SNOMEDCT_US |
| 386832008 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Ketoprofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0276-0504 | CAPSULE | 25 mg | ORAL | ANDA | 23 sections |
| Ketoprofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-8200 | CAPSULE, EXTENDED RELEASE | 200 mg | ORAL | ANDA | 29 sections |
| KETOPROFEN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-136 | CAPSULE | 50 mg | ORAL | ANDA | 28 sections |
| KETOPROFEN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-137 | CAPSULE | 75 mg | ORAL | ANDA | 28 sections |
| Ketoprofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-340 | CAPSULE | 50 mg | ORAL | ANDA | 30 sections |
| Ketoprofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-341 | CAPSULE | 75 mg | ORAL | ANDA | 30 sections |
| ketoprofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 23155-020 | CAPSULE | 25 mg | ORAL | ANDA | 13 sections |
| ketoprofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 23155-021 | CAPSULE | 50 mg | ORAL | ANDA | 13 sections |
| ketoprofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 23155-022 | CAPSULE | 75 mg | ORAL | ANDA | 13 sections |
| Ketoprofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-064 | CAPSULE | 75 mg | ORAL | ANDA | 28 sections |
| Ketoprofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42254-037 | CAPSULE | 75 mg | ORAL | ANDA | 28 sections |
| Ketoprofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45865-379 | CAPSULE | 75 mg | ORAL | ANDA | 28 sections |
| Ketoprofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45865-485 | CAPSULE | 50 mg | ORAL | ANDA | 28 sections |
| Ketoprofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-0453 | CAPSULE | 75 mg | ORAL | ANDA | 28 sections |
| Ketoprofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-2729 | CAPSULE | 50 mg | ORAL | ANDA | 28 sections |
| Ketoprofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52959-245 | CAPSULE | 50 mg | ORAL | ANDA | 28 sections |
| Ketoprofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 53217-221 | CAPSULE | 50 mg | ORAL | ANDA | 28 sections |
| Ketoprofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-2414 | CAPSULE | 50 mg | ORAL | ANDA | 30 sections |
| Ketoprofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-2415 | CAPSULE | 75 mg | ORAL | ANDA | 30 sections |
| Ketoprofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-4826 | CAPSULE, EXTENDED RELEASE | 200 mg | ORAL | ANDA | 30 sections |
| Ketoprofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63187-018 | CAPSULE | 75 mg | ORAL | ANDA | 28 sections |
| Ketoprofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 67296-0369 | TABLET | 75 mg | ORAL | ANDA | 28 sections |
| Ketoprofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 69336-127 | CAPSULE | 25 mg | ORAL | ANDA | 14 sections |