ketoprofen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
anti-inflammatory agents, ibuprofen derivatives	1528	22071-15-4

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: RP 19583 RP-19583 ketoprofen ketoprofene ketoprophen	An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It is used in the treatment of rheumatoid arthritis and osteoarthritis. Molecular weight: 254.29 Formula: C16H14O3 CLOGP: 2.76 LIPINSKI: 0 HAC: 3 HDO: 1 TPSA: 54.37 ALOGS: -4.08 ROTB: 4 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

RP 19583
RP-19583
ketoprofen
ketoprofene
ketoprophen

An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It is used in the treatment of rheumatoid arthritis and osteoarthritis.

Molecular weight: 254.29
Formula: C16H14O3
CLOGP: 2.76
LIPINSKI: 0
HAC: 3
HDO: 1
TPSA: 54.37
ALOGS: -4.08
ROTB: 4

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.15	g	O
0.15	g	P
0.15	g	R

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.18 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	0.50 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	19.66 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	90 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	0.13 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	1.60 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.01 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	2.10 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Jan. 9, 1986	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Temperature regulation disorder	483.88	13.78	138	19337	4330	56268262
Food allergy	395.29	13.78	139	19336	8685	56263907
Coeliac disease	370.12	13.78	138	19337	10201	56262391
Immunodeficiency	326.67	13.78	143	19332	16014	56256578
Bursitis	256.83	13.78	144	19331	27438	56245154
Rash erythematous	234.11	13.78	151	19324	37070	56235522
Fluid retention	162.88	13.78	141	19334	53937	56218655
Erythema	162.66	13.78	233	19242	155706	56116886
Upper respiratory tract infection	145.87	13.78	150	19325	71138	56201454
Acute kidney injury	142.55	13.78	279	19196	240484	56032108
Hyperhidrosis	139.09	13.78	167	19308	93921	56178671
Acute generalised exanthematous pustulosis	121.25	13.78	62	19413	9807	56262785
Asthma	115.27	13.78	167	19308	112603	56159989
Constipation	100.50	13.78	218	19257	201725	56070867
Hepatocellular injury	87.70	13.78	73	19402	26441	56246151
Goitre	77.24	13.78	38	19437	5535	56267057
Hepatic cytolysis	75.37	13.78	47	19428	10859	56261733
Angioedema	71.96	13.78	80	19395	41373	56231219
Back pain	71.73	13.78	212	19263	236958	56035634
Cholestasis	66.84	13.78	63	19412	26850	56245742
Face oedema	61.42	13.78	51	19424	18401	56254191
Hepatic enzyme increased	57.39	13.78	159	19316	171225	56101367
Pulmonary pain	56.57	13.78	25	19450	2855	56269737
Overdose	53.39	13.78	115	19360	105715	56166877
Poisoning deliberate	49.63	13.78	35	19440	9918	56262674
Suicide attempt	48.22	13.78	78	19397	57758	56214834
Peripheral nerve injury	45.88	13.78	13	19462	397	56272195
Alopecia	43.07	13.78	24	19451	293434	55979158
Drug hypersensitivity	42.45	13.78	198	19277	275007	55997585
Hepatic adenoma	40.55	13.78	11	19464	285	56272307
Spinal epidural haemorrhage	40.23	13.78	9	19466	101	56272491
Lactic acidosis	39.97	13.78	55	19420	35291	56237301
Hypersensitivity	36.29	13.78	180	19295	256228	56016364
Systemic lupus erythematosus	35.96	13.78	9	19466	180069	56092523
Toxic skin eruption	34.07	13.78	30	19445	11709	56260883
Anaphylactic shock	32.73	13.78	39	19436	21701	56250891
Coma	32.59	13.78	67	19408	59588	56213004
Aspirin-exacerbated respiratory disease	32.17	13.78	12	19463	885	56271707
Hepatic function abnormal	32.11	13.78	49	19426	34509	56238083
Burning mouth syndrome	31.83	13.78	10	19465	438	56272154
Death	31.82	13.78	43	19432	341383	55931209
Lip and/or oral cavity cancer	31.58	13.78	11	19464	666	56271926
Gastritis erosive	31.07	13.78	21	19454	5556	56267036
Headache	30.49	13.78	311	19164	558733	55713859
Tubulointerstitial nephritis	30.36	13.78	33	19442	16632	56255960
Completed suicide	30.22	13.78	5	19470	133828	56138764
Therapeutic product effect decreased	29.28	13.78	11	19464	169441	56103151
Synovitis	28.67	13.78	10	19465	161295	56111297
Epidural haemorrhage	28.60	13.78	7	19468	119	56272473
Hand deformity	28.28	13.78	6	19469	134486	56138106
Fine motor skill dysfunction	27.75	13.78	18	19457	4447	56268145
Wound	27.58	13.78	7	19468	138797	56133795
Pneumoperitoneum	27.33	13.78	12	19463	1349	56271243
Melaena	26.12	13.78	40	19435	28250	56244342
Pneumococcal sepsis	25.62	13.78	9	19466	559	56272033
Sinoatrial block	25.61	13.78	10	19465	836	56271756
Drug interaction	25.35	13.78	141	19334	209614	56062978
Femoral artery dissection	25.13	13.78	5	19470	30	56272562
Glomerulonephropathy	25.03	13.78	6	19469	93	56272499
Rheumatoid arthritis	24.85	13.78	221	19254	382383	55890209
Intentional overdose	24.56	13.78	65	19410	68052	56204540
Vanishing bile duct syndrome	23.97	13.78	9	19466	676	56271916
Upper respiratory tract inflammation	23.21	13.78	13	19462	2464	56270128
Nephrolithiasis	22.87	13.78	44	19431	37291	56235301
Drug abuse	22.85	13.78	63	19412	67547	56205045
Epidural analgesia	22.70	13.78	5	19470	52	56272540
Sinusitis	22.63	13.78	21	19454	197560	56075032
Foetal heart rate abnormal	22.32	13.78	8	19467	527	56272065
Hypertransaminasaemia	22.19	13.78	16	19459	4691	56267901
Septic shock	21.88	13.78	58	19417	60777	56211815
Duplicate therapy error	21.75	13.78	5	19470	64	56272528
Hepatitis acute	21.58	13.78	20	19455	8337	56264255
Toxic epidermal necrolysis	21.54	13.78	32	19443	22010	56250582
Miosis	21.47	13.78	18	19457	6574	56266018
Weight increased	21.30	13.78	29	19446	229674	56042918
Inflammation	21.05	13.78	62	19413	69009	56203583
Atypical haemolytic uraemic syndrome	20.99	13.78	8	19467	626	56271966
Pancreatitis necrotising	20.87	13.78	10	19465	1374	56271218
Pericarditis	20.68	13.78	6	19469	108917	56163675
Blister	20.67	13.78	6	19469	108881	56163711
Amyloid arthropathy	20.56	13.78	6	19469	204	56272388
Nasal disorder	20.07	13.78	12	19463	2570	56270022
Upper gastrointestinal haemorrhage	19.98	13.78	27	19448	17027	56255565
Mixed anxiety and depressive disorder	19.82	13.78	6	19469	232	56272360
Pancreatitis acute	19.73	13.78	33	19442	25091	56247501
Gastric ulcer	19.57	13.78	31	19444	22532	56250060
Oedematous pancreatitis	19.46	13.78	7	19468	466	56272126
Product dispensing issue	18.92	13.78	5	19470	117	56272475
Ankylosing spondylitis	18.67	13.78	20	19455	9910	56262682
Drug intolerance	18.54	13.78	40	19435	264778	56007814
Abdominal discomfort	18.50	13.78	43	19432	277231	55995361
Linear IgA disease	18.46	13.78	9	19466	1284	56271308
Reversible cerebral vasoconstriction syndrome	18.35	13.78	11	19464	2366	56270226
Vascular purpura	18.10	13.78	9	19466	1341	56271251
Mobility decreased	17.82	13.78	6	19469	98985	56173607
Maternal exposure during pregnancy	17.50	13.78	24	19451	189529	56083063
Enteritis infectious	17.38	13.78	10	19465	1994	56270598
Spinal compression fracture	17.25	13.78	22	19453	13112	56259480
Gastroenteropancreatic neuroendocrine tumour disease	17.20	13.78	4	19471	54	56272538
Azotaemia	17.06	13.78	13	19462	4145	56268447
Product dose omission issue	16.90	13.78	28	19447	204725	56067867
Social anxiety disorder	16.61	13.78	6	19469	404	56272188
Pyelonephritis acute	16.60	13.78	13	19462	4316	56268276
Drug ineffective	16.44	13.78	222	19253	918767	55353825
Impaired healing	16.09	13.78	5	19470	86836	56185756
Inflammatory bowel disease	15.94	13.78	12	19463	3756	56268836
Gastric ulcer haemorrhage	15.77	13.78	13	19462	4640	56267952
Pyelonephritis	15.28	13.78	23	19452	16001	56256591
Arthritis bacterial	14.88	13.78	14	19461	5947	56266645
Renal cortical necrosis	14.81	13.78	4	19471	102	56272490
Thyroid disorder	14.73	13.78	21	19454	13917	56258675
Dermatitis exfoliative generalised	14.71	13.78	11	19464	3409	56269183
Thyroid cancer	14.70	13.78	13	19462	5103	56267489
Drug level increased	14.67	13.78	26	19449	20699	56251893
Enterocolitis	14.59	13.78	15	19460	7089	56265503
Prescribed overdose	14.55	13.78	27	19448	22269	56250323
Intervertebral discitis	14.29	13.78	10	19465	2797	56269795
Infusion related reaction	14.25	13.78	32	19443	208899	56063693
Hepatitis cholestatic	14.01	13.78	14	19461	6400	56266192
Atrioventricular block complete	13.93	13.78	15	19460	7479	56265113
Odontogenic cyst	13.82	13.78	3	19472	29	56272563

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	116.77	14.63	281	10692	279433	31406938
Angioedema	95.90	14.63	85	10888	33533	31652838
Anaphylactic shock	73.50	14.63	51	10922	14094	31672277
Acute generalised exanthematous pustulosis	57.43	14.63	32	10941	6008	31680363
Lactic acidosis	52.65	14.63	60	10913	31877	31654494
Drug interaction	50.85	14.63	173	10800	208370	31478001
Poisoning deliberate	49.11	14.63	31	10942	7313	31679058
Death	46.98	14.63	34	10939	360535	31325836
Suicide attempt	46.80	14.63	61	10912	37187	31649184
Pancreatitis acute	43.73	14.63	49	10924	25551	31660820
Hepatocellular injury	43.40	14.63	45	10928	21499	31664872
Vascular purpura	43.35	14.63	17	10956	1437	31684934
Radiation inflammation	37.54	14.63	12	10961	556	31685815
Erythema	36.76	14.63	84	10889	80321	31606050
Hepatitis cholestatic	35.33	14.63	25	10948	7121	31679250
Cholestasis	34.54	14.63	43	10930	25032	31661339
Pulmonary pain	33.36	14.63	12	10961	798	31685573
Myoclonic epilepsy	33.15	14.63	13	10960	1099	31685272
Mixed liver injury	32.57	14.63	16	10957	2321	31684050
Hyperaesthesia	32.38	14.63	19	10954	3932	31682439
Gastric ulcer	32.08	14.63	32	10941	14602	31671769
Palatal oedema	30.65	14.63	11	10962	727	31685644
Enterocolitis	30.41	14.63	23	10950	7251	31679120
Drug level increased	30.04	14.63	36	10937	20150	31666221
Eyelid oedema	28.90	14.63	19	10954	4801	31681570
Tongue oedema	27.61	14.63	15	10958	2678	31683693
Fusobacterium infection	25.87	14.63	6	10967	80	31686291
Coma	25.84	14.63	49	10924	41101	31645270
Melaena	25.80	14.63	43	10930	32611	31653760
Blood lactic acid	25.74	14.63	8	10965	338	31686033
Laryngeal discomfort	25.35	14.63	7	10966	194	31686177
Allergy test negative	25.11	14.63	4	10969	4	31686367
Polyneuropathy in malignant disease	24.03	14.63	6	10967	111	31686260
Rash pustular	23.74	14.63	17	10956	4932	31681439
Intentional overdose	23.21	14.63	47	10926	41342	31645029
Type I hypersensitivity	22.82	14.63	10	10963	1118	31685253
Dermatitis bullous	22.32	14.63	18	10955	6227	31680144
Necrotising myositis	21.89	14.63	8	10965	557	31685814
Dyschezia	21.50	14.63	10	10963	1285	31685086
Lung neoplasm malignant	21.02	14.63	27	10946	16203	31670168
Fatigue	20.91	14.63	54	10919	335152	31351219
Renal vasculitis	20.90	14.63	6	10967	192	31686179
Rash maculo-papular	20.49	14.63	34	10939	25685	31660686
Anorgasmia	19.79	14.63	8	10965	732	31685639
Anaemia	19.20	14.63	133	10840	213389	31472982
Diarrhoea infectious	19.18	14.63	7	10966	485	31685886
Vitello-intestinal duct remnant	19.08	14.63	5	10968	113	31686258
Meningoencephalitis bacterial	18.52	14.63	5	10968	127	31686244
Pruritus	18.49	14.63	89	10884	125078	31561293
Altered state of consciousness	18.36	14.63	29	10944	21022	31665349
Liver injury	18.35	14.63	23	10950	13469	31672902
Prothrombin time shortened	17.76	14.63	9	10964	1395	31684976
Hepatic function abnormal	17.64	14.63	42	10931	41180	31645191
Miosis	17.43	14.63	18	10955	8552	31677819
Brain empyema	17.30	14.63	3	10970	7	31686364
Anterograde amnesia	17.18	14.63	5	10968	168	31686203
Hyperkalaemia	17.03	14.63	55	10918	64296	31622075
Gastric ulcer haemorrhage	16.71	14.63	14	10959	5109	31681262
Rhinitis allergic	16.50	14.63	11	10962	2843	31683528
Vomiting	16.45	14.63	133	10840	223840	31462531
Epilepsy congenital	16.08	14.63	3	10970	12	31686359
Interstitial lung disease	15.82	14.63	52	10921	61351	31625020
Pallor	15.70	14.63	28	10945	22396	31663975
Off label use	15.39	14.63	65	10908	347209	31339162
Overdose	15.35	14.63	64	10909	84600	31601771
Pathological fracture	15.09	14.63	12	10961	4070	31682301
Allergic colitis	14.68	14.63	3	10970	21	31686350

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Temperature regulation disorder	459.69	12.40	136	27464	4308	70896536
Food allergy	376.41	12.40	137	27463	8387	70892457
Coeliac disease	365.00	12.40	136	27464	8897	70891947
Immunodeficiency	299.08	12.40	143	27457	17412	70883432
Bursitis	234.94	12.40	140	27460	26533	70874311
Acute kidney injury	225.28	12.40	539	27061	474085	70426759
Erythema	188.10	12.40	303	27297	199260	70701584
Rash erythematous	188.05	12.40	158	27442	51560	70849284
Acute generalised exanthematous pustulosis	157.27	12.40	89	27511	15308	70885536
Angioedema	153.84	12.40	158	27442	66452	70834392
Fluid retention	136.78	12.40	145	27455	63240	70837604
Hyperhidrosis	124.11	12.40	200	27400	131386	70769458
Hepatocellular injury	120.54	12.40	117	27483	45974	70854870
Upper respiratory tract infection	118.34	12.40	150	27450	79124	70821720
Constipation	100.75	12.40	269	27331	252169	70648675
Anaphylactic shock	95.49	12.40	88	27512	32402	70868442
Asthma	90.71	12.40	166	27434	120627	70780217
Cholestasis	88.49	12.40	101	27499	47771	70853073
Poisoning deliberate	87.72	12.40	64	27536	16996	70883848
Pulmonary pain	86.95	12.40	37	27563	3425	70897419
Lactic acidosis	83.05	12.40	114	27486	64910	70835934
Back pain	74.17	12.40	253	27347	270899	70629945
Suicide attempt	72.39	12.40	119	27481	79391	70821453
Death	67.05	12.40	60	27540	510001	70390843
Hepatic cytolysis	64.34	12.40	56	27544	19136	70881708
Drug interaction	64.27	12.40	306	27294	381135	70519709
Face oedema	61.29	12.40	62	27538	25577	70875267
Pancreatitis acute	57.30	12.40	79	27521	45145	70855699
Hepatic enzyme increased	57.27	12.40	162	27438	156828	70744016
Vascular purpura	54.89	12.40	25	27575	2721	70898123
Overdose	53.21	12.40	166	27434	169579	70731265
Completed suicide	52.53	12.40	12	27588	227123	70673721
Coma	49.51	12.40	110	27490	91734	70809110
Hypersensitivity	49.02	12.40	198	27402	229614	70671230
Drug hypersensitivity	48.16	12.40	216	27384	262243	70638601
Hepatitis cholestatic	44.61	12.40	38	27562	12612	70888232
Gastric ulcer	44.03	12.40	58	27542	31732	70869112
Drug level increased	43.65	12.40	62	27538	36407	70864437
Enterocolitis	43.54	12.40	38	27562	13028	70887816
Hepatic adenoma	39.31	12.40	11	27589	284	70900560
Peripheral nerve injury	38.03	12.40	13	27587	660	70900184
Aspirin-exacerbated respiratory disease	37.33	12.40	15	27585	1200	70899644
Melaena	36.77	12.40	73	27527	56282	70844562
Eyelid oedema	36.47	12.40	34	27566	12693	70888151
Tubulointerstitial nephritis	36.34	12.40	54	27546	33022	70867822
Radiation inflammation	36.16	12.40	12	27588	556	70900288
Hepatic function abnormal	32.83	12.40	78	27522	67918	70832926
Goitre	32.66	12.40	22	27578	5144	70895700
Laryngeal discomfort	32.22	12.40	11	27589	556	70900288
Miosis	31.71	12.40	33	27567	14068	70886776
Spinal epidural haemorrhage	31.21	12.40	8	27592	146	70900698
Burning mouth syndrome	29.38	12.40	10	27590	501	70900343
Rheumatoid arthritis	29.22	12.40	204	27396	291601	70609243
Gastritis erosive	28.98	12.40	27	27573	10068	70890776
Weight increased	28.88	12.40	31	27569	242300	70658544
Intentional overdose	27.85	12.40	93	27507	98342	70802502
Altered state of consciousness	27.51	12.40	53	27547	39969	70860875
Lip and/or oral cavity cancer	27.17	12.40	11	27589	898	70899946
Gastric ulcer haemorrhage	26.84	12.40	24	27576	8494	70892350
Foetal heart rate abnormal	26.83	12.40	8	27592	260	70900584
Hepatitis acute	26.71	12.40	30	27570	13932	70886912
Rash maculo-papular	25.51	12.40	59	27541	50486	70850358
Toxic skin eruption	25.20	12.40	35	27565	20127	70880717
Mixed liver injury	24.58	12.40	20	27580	6229	70894615
Sinusitis	24.54	12.40	18	27582	169177	70731667
Synovitis	24.16	12.40	10	27590	129218	70771626
Ankylosing spondylitis	23.96	12.40	26	27574	11620	70889224
Palatal oedema	23.90	12.40	11	27589	1227	70899617
Epidural haemorrhage	23.85	12.40	7	27593	215	70900629
Femoral artery dissection	23.40	12.40	5	27595	39	70900805
Contraindicated product administered	23.32	12.40	109	27491	134503	70766341
Fusobacterium infection	22.99	12.40	6	27594	118	70900726
Dermatofibrosarcoma protuberans	22.77	12.40	5	27595	45	70900799
Blood lactic acid	22.53	12.40	8	27592	455	70900389
Pneumoperitoneum	22.53	12.40	14	27586	2855	70897989
Epidural analgesia	21.94	12.40	5	27595	54	70900790
Hyperaesthesia	21.77	12.40	24	27576	10918	70889926
Polyneuropathy in malignant disease	21.47	12.40	6	27594	154	70900690
Allergy test negative	21.18	12.40	4	27596	15	70900829
Glossodynia	21.15	12.40	4	27596	86483	70814361
Therapeutic product effect decreased	21.02	12.40	15	27585	143003	70757841
Upper respiratory tract inflammation	20.74	12.40	15	27585	3927	70896917
Urticaria	20.62	12.40	121	27479	162928	70737916
Hypertransaminasaemia	20.23	12.40	21	27579	8922	70891922
Meningoencephalitis bacterial	20.09	12.40	6	27594	196	70900648
Amyloid arthropathy	19.86	12.40	6	27594	204	70900640
Fine motor skill dysfunction	19.59	12.40	16	27584	5008	70895836
Photosensitivity reaction	19.02	12.40	30	27570	19310	70881534
Intentional product misuse	18.90	12.40	71	27529	79524	70821320
Mixed anxiety and depressive disorder	18.85	12.40	6	27594	243	70900601
Dermatitis bullous	18.79	12.40	24	27576	12733	70888111
Fall	18.76	12.40	99	27501	443997	70456847
Anaphylactic reaction	18.75	12.40	68	27532	74906	70825938
Cerebrovascular accident	18.64	12.40	17	27583	143453	70757391
Tongue oedema	18.47	12.40	17	27583	6242	70894602
Vitello-intestinal duct remnant	18.33	12.40	5	27595	117	70900727
Hyperkalaemia	18.23	12.40	86	27514	106505	70794339
Product dispensing issue	18.13	12.40	5	27595	122	70900722
Lip oedema	18.12	12.40	16	27584	5567	70895277
Atypical haemolytic uraemic syndrome	17.93	12.40	8	27592	830	70900014
Off label use	17.89	12.40	194	27406	742866	70157978
Mediastinitis	17.84	12.40	8	27592	840	70900004
Intervertebral discitis	17.82	12.40	14	27586	4147	70896697
Sinoatrial block	17.64	12.40	9	27591	1257	70899587
Glomerulonephropathy	17.34	12.40	6	27594	316	70900528
Lethargy	17.33	12.40	4	27596	75246	70825598
Systemic lupus erythematosus	17.32	12.40	9	27591	101893	70798951
Hand deformity	17.32	12.40	6	27594	86476	70814368
Headache	17.17	12.40	319	27281	580086	70320758
Vanishing bile duct syndrome	17.04	12.40	9	27591	1350	70899494
Anxiety	16.86	12.40	38	27562	220292	70680552
Dermo-hypodermitis	16.81	12.40	7	27593	614	70900230
Pericarditis	16.75	12.40	6	27594	84699	70816145
Hepatitis	16.68	12.40	50	27550	49930	70850914
Septic shock	16.66	12.40	87	27513	112171	70788673
Vomiting	16.52	12.40	323	27277	592788	70308056
Oedematous pancreatitis	16.48	12.40	8	27592	1005	70899839
Wound	16.37	12.40	9	27591	98723	70802121
Shock haemorrhagic	16.33	12.40	27	27573	18079	70882765
Necrotising myositis	16.24	12.40	8	27592	1038	70899806
Gastroenteropancreatic neuroendocrine tumour disease	16.22	12.40	4	27596	62	70900782
Inflammation	16.12	12.40	67	27533	78598	70822246
Anorgasmia	15.96	12.40	8	27592	1077	70899767
Reversible cerebral vasoconstriction syndrome	15.94	12.40	11	27589	2674	70898170
Hepatic failure	15.90	12.40	54	27546	57571	70843273
Hyperleukocytosis	15.43	12.40	10	27590	2191	70898653
Fracture displacement	15.08	12.40	8	27592	1210	70899634
Prothrombin time shortened	15.04	12.40	11	27589	2931	70897913
Lung neoplasm malignant	14.89	12.40	31	27569	24711	70876133
Drug intolerance	14.88	12.40	42	27558	225645	70675199
Brain empyema	14.87	12.40	3	27597	17	70900827
Osteomyelitis	14.87	12.40	35	27565	30283	70870561
Social anxiety disorder	14.83	12.40	6	27594	489	70900355
Type I hypersensitivity	14.80	12.40	12	27588	3720	70897124
Product dose omission issue	14.69	12.40	40	27560	217428	70683416
Duplicate therapy error	14.62	12.40	5	27595	254	70900590
Chronic obstructive pulmonary disease	14.52	12.40	6	27594	77635	70823209
Drug-disease interaction	14.37	12.40	7	27593	886	70899958
Odontogenic cyst	14.33	12.40	3	27597	21	70900823
Dizziness	14.23	12.40	114	27486	464027	70436817
Metabolic acidosis	14.21	12.40	62	27538	74284	70826560
Anaemia	14.17	12.40	228	27372	403195	70497649
Nasal congestion	14.15	12.40	4	27596	65668	70835176
Drug ineffective	13.95	12.40	270	27330	939482	69961362
Nasal disorder	13.87	12.40	11	27589	3303	70897541
Allergic colitis	13.87	12.40	3	27597	25	70900819
Dyschezia	13.83	12.40	10	27590	2617	70898227
Pancreatitis necrotising	13.83	12.40	11	27589	3317	70897527
Colon cancer	13.81	12.40	22	27578	14284	70886560
Dyspnoea	13.74	12.40	214	27386	769846	70130998
Renal vasculitis	13.69	12.40	6	27594	596	70900248
Chills	13.67	12.40	22	27578	144764	70756080
Endothelin increased	13.66	12.40	3	27597	27	70900817
Pneumococcal sepsis	13.65	12.40	8	27592	1468	70899376
Impaired healing	13.51	12.40	6	27594	74368	70826476
Thyroid cancer	13.32	12.40	13	27587	5132	70895712
Femoral neck fracture	13.25	12.40	17	27583	9056	70891788
Gastrointestinal disorder	13.10	12.40	13	27587	105414	70795430
Alopecia	13.04	12.40	37	27563	198453	70702391
Drug abuse	13.02	12.40	100	27500	147156	70753688
Arthritis bacterial	12.94	12.40	16	27584	8217	70892627
Prescribed overdose	12.92	12.40	31	27569	27150	70873694
Cutaneous vasculitis	12.91	12.40	15	27585	7223	70893621
Pruritus allergic	12.91	12.40	7	27593	1107	70899737
Flushing	12.90	12.40	8	27592	82164	70818680
Femur fracture	12.87	12.40	37	27563	36095	70864749
Meningitis aseptic	12.63	12.40	14	27586	6405	70894439
Intentional product use issue	12.57	12.40	17	27583	120125	70780719
Spinal compression fracture	12.45	12.40	22	27578	15531	70885313

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	M01AE03	MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Propionic acid derivatives
ATC	M01AE53	MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Propionic acid derivatives
ATC	M02AA10	MUSCULO-SKELETAL SYSTEM TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN Antiinflammatory preparations, non-steroids for topical use
FDA CS	M0001335	Anti-Inflammatory Agents, Non-Steroidal
FDA MoA	N0000000160	Cyclooxygenase Inhibitors
MeSH PA	D000700	Analgesics
MeSH PA	D018712	Analgesics, Non-Narcotic
MeSH PA	D000893	Anti-Inflammatory Agents
MeSH PA	D000894	Anti-Inflammatory Agents, Non-Steroidal
MeSH PA	D018501	Antirheumatic Agents
MeSH PA	D016861	Cyclooxygenase Inhibitors
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D018689	Sensory System Agents
CHEBI has role	CHEBI:35475	non-steroidal anti-inflammatory agent
CHEBI has role	CHEBI:35493	anti-pyretic
CHEBI has role	CHEBI:35544	cyclooxygenase inhibitors
CHEBI has role	CHEBI:35703	Xenobiotic
CHEBI has role	CHEBI:78298	environmental contaminants
CHEBI has role	CHEBI:88188	allergenic drug
FDA EPC	N0000175722	Nonsteroidal Anti-inflammatory Drug

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Pain	indication	22253000
Rheumatoid arthritis	indication	69896004	DOID:7148
Dysmenorrhea	indication	266599000
Osteoarthritis	indication	396275006
Ankylosing spondylitis	off-label use	9631008	DOID:7147
Gout	off-label use	90560007	DOID:13189
Vascular headache	off-label use	128187005
Peptic ulcer	contraindication	13200003	DOID:750
Myocardial infarction	contraindication	22298006	DOID:5844
Hypertensive disorder	contraindication	38341003	DOID:10763
Gastrointestinal ulcer	contraindication	40845000
Chronic heart failure	contraindication	48447003
Disorder of cardiovascular system	contraindication	49601007	DOID:1287
Hepatic failure	contraindication	59927004
Blood coagulation disorder	contraindication	64779008	DOID:1247
Gastrointestinal hemorrhage	contraindication	74474003
Kidney disease	contraindication	90708001	DOID:557
Hypoalbuminemia	contraindication	119247004
Coronary artery bypass graft	contraindication	232717009
Pregnancy, function	contraindication	289908002
Cardiovascular event risk	contraindication	395112001
Smokes tobacco daily	contraindication	449868002

🐶 Veterinary Drug Use

Species	Use	Relation
Horses	Pain and inflammation associated with musculoskeletal disorders	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
KETOFEN	Zoetis Inc.	1
Draxxin KP	Zoetis Inc.	2
KetoMed	Bimeda Animal Health Limited	1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.28	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Prostaglandin G/H synthase 2	Enzyme	P35354	PGH2_HUMAN	INHIBITOR	IC50	6.62	WOMBAT-PK	CHEMBL
Prostaglandin G/H synthase 1	Enzyme	P23219	PGH1_HUMAN	INHIBITOR	IC50	7.33	WOMBAT-PK	CHEMBL
Prostaglandin G/H synthase 1	Enzyme		PGH1_SHEEP		IC50	6.10	CHEMBL
Prostaglandin G/H synthase 2	Enzyme		PGH2_SHEEP		IC50	6.75	CHEMBL
Cyclooxygenase	Enzyme		PGH1_BOVIN PGH2_BOVIN		IC50	5.47	CHEMBL

External reference:

ID	Source
4018064	VUID
N0000146405	NUI
D00132	KEGG_DRUG
4018064	VANDF
C0022635	UMLSCUI
CHEBI:6128	CHEBI
CHEMBL571	ChEMBL_ID
DB01009	DRUGBANK_ID
D007660	MESH_DESCRIPTOR_UI
3825	PUBCHEM_CID
4795	IUPHAR_LIGAND_ID
3284	INN_ID
90Y4QC304K	UNII
6142	RXNORM
3365	MMSL
4946	MMSL
d00028	MMSL
002394	NDDF
10099000	SNOMEDCT_US
386832008	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	0276-0504	CAPSULE	25 mg	ORAL	ANDA	23 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	0276-0504	CAPSULE	25 mg	ORAL	ANDA	23 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	0276-0506	CAPSULE	50 mg	ORAL	ANDA	23 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	0378-8200	CAPSULE, EXTENDED RELEASE	200 mg	ORAL	ANDA	29 sections
KETOPROFEN	HUMAN PRESCRIPTION DRUG LABEL	1	16590-136	CAPSULE	50 mg	ORAL	ANDA	28 sections
KETOPROFEN	HUMAN PRESCRIPTION DRUG LABEL	1	16590-137	CAPSULE	75 mg	ORAL	ANDA	28 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	21695-340	CAPSULE	50 mg	ORAL	ANDA	30 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	21695-341	CAPSULE	75 mg	ORAL	ANDA	30 sections
ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	23155-020	CAPSULE	25 mg	ORAL	ANDA	13 sections
ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	23155-021	CAPSULE	50 mg	ORAL	ANDA	13 sections
ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	23155-022	CAPSULE	75 mg	ORAL	ANDA	13 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	33261-064	CAPSULE	75 mg	ORAL	ANDA	28 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	42254-037	CAPSULE	75 mg	ORAL	ANDA	28 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	45865-379	CAPSULE	75 mg	ORAL	ANDA	28 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	45865-485	CAPSULE	50 mg	ORAL	ANDA	28 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	50090-0453	CAPSULE	75 mg	ORAL	ANDA	28 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	50090-2729	CAPSULE	50 mg	ORAL	ANDA	28 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	52959-245	CAPSULE	50 mg	ORAL	ANDA	28 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	53217-221	CAPSULE	50 mg	ORAL	ANDA	28 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	54868-2414	CAPSULE	50 mg	ORAL	ANDA	30 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	54868-2415	CAPSULE	75 mg	ORAL	ANDA	30 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	54868-4826	CAPSULE, EXTENDED RELEASE	200 mg	ORAL	ANDA	30 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	63187-018	CAPSULE	75 mg	ORAL	ANDA	28 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	67296-0369	TABLET	75 mg	ORAL	ANDA	28 sections
Ketoprofen	HUMAN PRESCRIPTION DRUG LABEL	1	69336-127	CAPSULE	25 mg	ORAL	ANDA	14 sections