josamycin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, produced by Streptomyces strains 1518 16846-24-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • josamycin
  • Leucomycin A3
  • iosalide
  • josacine
  • josamina
  • Turimycin A5
A macrolide antibiotic from Streptomyces narbonensis. The drug has antimicrobial activity against a wide spectrum of pathogens.
  • Molecular weight: 828.01
  • Formula: C42H69NO15
  • CLOGP: 3.67
  • LIPINSKI: 2
  • HAC: 16
  • HDO: 3
  • TPSA: 206.05
  • ALOGS: -4.19
  • ROTB: 14

Drug dosage:

DoseUnitRoute
2 g O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01FA07 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
Macrolides
CHEBI has role CHEBI:25212 metabolites
CHEBI has role CHEBI:36047 antibacterial drugs
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.8 acidic
pKa2 13.95 acidic
pKa3 7.88 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
N0000168421 NUI
D01235 KEGG_DRUG
C0022419 UMLSCUI
CHEBI:31739 CHEBI
JOS PDB_CHEM_ID
CHEMBL224436 ChEMBL_ID
D015570 MESH_DESCRIPTOR_UI
DB01321 DRUGBANK_ID
2837 INN_ID
HV13HFS217 UNII
5282165 PUBCHEM_CID
6084 RXNORM
005267 NDDF
713477009 SNOMEDCT_US

Pharmaceutical products:

None