itopride 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
sulpiride derivatives and analogues	1512	122898-67-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: itopride hydrochloride ganaton itopride itropride itopride HCl	Molecular weight: 358.44 Formula: C20H26N2O4 CLOGP: 2.64 LIPINSKI: 0 HAC: 6 HDO: 1 TPSA: 60.03 ALOGS: -4.14 ROTB: 9

Molecule

Description

Molfile Inchi Smiles

Synonyms:

itopride hydrochloride
ganaton
itopride
itropride
itopride HCl

Molecular weight: 358.44
Formula: C20H26N2O4
CLOGP: 2.64
LIPINSKI: 0
HAC: 6
HDO: 1
TPSA: 60.03
ALOGS: -4.14
ROTB: 9

Drug dosage:

Dose	Unit	Route
0.15	g	O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Trimethylaminuria	153.57	56.00	19	783	154	63488066
Pseudomembranous colitis	98.70	56.00	19	783	3093	63485127
Peritonitis	89.55	56.00	24	778	17130	63471090
Megacolon	88.10	56.00	16	786	1899	63486321
Dysbiosis	78.58	56.00	13	789	893	63487327
Intestinal perforation	73.22	56.00	19	783	11944	63476276
Drug interaction	66.15	56.00	39	763	229092	63259128

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FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Trimethylaminuria	158.02	37.37	20	1099	176	79743093
Pseudomembranous colitis	91.87	37.37	20	1099	5354	79737915
Megacolon	82.60	37.37	17	1102	3478	79739791
Dysbiosis	80.01	37.37	14	1105	1205	79742064
Peritonitis	79.46	37.37	25	1094	28011	79715258
Intestinal perforation	68.50	37.37	20	1099	17406	79725863
Inhibitory drug interaction	45.99	37.37	11	1108	4442	79738827
Drug interaction	45.39	37.37	41	1078	415142	79328127
Clostridium difficile infection	43.99	37.37	18	1101	42667	79700602
Breath odour	38.59	37.37	8	1111	1688	79741581

Showing 1 to 10 of 12 entries

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	A03FA07	ALIMENTARY TRACT AND METABOLISM DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS PROPULSIVES Propulsives

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Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Chronic gastritis	indication	8493009

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.61	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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ID	Source
017624	NDDF
017625	NDDF
1217454005	SNOMEDCT_US
122892-31-3	SECONDARY_CAS_RN
20691000122100	SNOMEDCT_US
3792	PUBCHEM_CID
6879	INN_ID
81BMQ80QRL	UNII
C0531483	UMLSCUI
C102254	MESH_SUPPLEMENTAL_RECORD_UI

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Pharmaceutical products:

None