isoxsuprine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1510 | 395-28-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle. Its vasodilating actions are greater on the arteries supplying skeletal muscle than on those supplying skin. It is used in the treatment of peripheral vascular disease and in premature labor.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 60 | mg | O |
| 60 | mg | P |
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C04AA01 | CARDIOVASCULAR SYSTEM PERIPHERAL VASODILATORS PERIPHERAL VASODILATORS 2-amino-1-phenylethanol derivatives |
| MeSH PA | D018663 | Adrenergic Agents |
| MeSH PA | D000322 | Adrenergic Agonists |
| MeSH PA | D000318 | Adrenergic beta-Agonists |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D012102 | Reproductive Control Agents |
| MeSH PA | D013566 | Sympathomimetics |
| MeSH PA | D015149 | Tocolytic Agents |
| MeSH PA | D014665 | Vasodilator Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Disorder of blood vessel | indication | 27550009 | DOID:178 |
| Cerebrovascular disease | indication | 62914000 | DOID:6713 |
| Raynaud's disease | indication | 195295006 | DOID:10300 |
| Dysmenorrhea | off-label use | 266599000 | |
| Tachyarrhythmia | contraindication | 6285003 | |
| Low blood pressure | contraindication | 45007003 | |
| Arterial hemorrhage | contraindication | 234003006 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 10.52 | acidic |
| pKa2 | 8.54 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4019794 | VUID |
| N0000147883 | NUI |
| D01748 | KEGG_DRUG |
| 579-56-6 | SECONDARY_CAS_RN |
| 4017883 | VANDF |
| 4019794 | VANDF |
| C0022267 | UMLSCUI |
| CHEBI:91855 | CHEBI |
| CHEMBL1197051 | ChEMBL_ID |
| CHEMBL559180 | ChEMBL_ID |
| DB08941 | DRUGBANK_ID |
| D007556 | MESH_DESCRIPTOR_UI |
| 3783 | PUBCHEM_CID |
| 773 | INN_ID |
| R15UI3245N | UNII |
| 6066 | RXNORM |
| 3350 | MMSL |
| 4938 | MMSL |
| d00693 | MMSL |
| 000700 | NDDF |
| 004517 | NDDF |
| 3501003 | SNOMEDCT_US |
| 372818004 | SNOMEDCT_US |
| 68774008 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| ISOXSUPRINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51293-605 | TABLET | 20 mg | ORAL | UNAPPROVED DRUG OTHER | 9 sections |
| ISOXSUPRINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51293-606 | TABLET | 10 mg | ORAL | UNAPPROVED DRUG OTHER | 9 sections |
| ISOXSUPRINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63549-919 | TABLET | 20 mg | ORAL | UNAPPROVED DRUG OTHER | 10 sections |