isosorbide mononitrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
NO2 - derivatives 1506 16051-77-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • isosorbide mononitrate
  • isosorbide 5-mononitrate
  • isosorbide 5-nitrate
  • monosorbitrate
  • isosorbide-5-mononitrate
for prevention of angina pectoris; structure given in first source; a Russian drug
  • Molecular weight: 191.14
  • Formula: C6H9NO6
  • CLOGP: -0.81
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 93.74
  • ALOGS: -0.53
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
40 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1.10 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 2.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 8.97 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 93 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.70 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 1 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 4.10 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 30, 1991 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 394.05 13.34 335 27299 99558 63361830
Cardiac failure congestive 271.91 13.34 263 27371 92170 63369218
Acute myocardial infarction 180.83 13.34 133 27501 31991 63429397
Subarachnoid haemorrhage 173.12 13.34 96 27538 14187 63447201
Cardiospasm 172.35 13.34 54 27580 1853 63459535
Palmoplantar keratoderma 169.63 13.34 54 27580 1953 63459435
Pruritus genital 158.68 13.34 55 27579 2599 63458789
Sleep terror 154.31 13.34 54 27580 2626 63458762
Chest pain 153.57 13.34 309 27325 215650 63245738
Coronary artery disease 149.18 13.34 119 27515 32258 63429130
Angina pectoris 141.68 13.34 112 27522 29966 63431422
Atrial tachycardia 140.43 13.34 57 27577 4183 63457205
Carotid artery occlusion 131.51 13.34 56 27578 4638 63456750
Tension headache 129.36 13.34 57 27577 5129 63456259
Drug ineffective 118.96 13.34 170 27464 1044595 62416793
Immunisation 108.72 13.34 34 27600 1159 63460229
Anosmia 108.27 13.34 55 27579 6805 63454583
Ventricular tachycardia 106.32 13.34 80 27554 19899 63441489
Hypoglycaemia 104.85 13.34 130 27504 59935 63401453
Acute kidney injury 87.87 13.34 283 27351 263132 63198256
Lip swelling 86.73 13.34 86 27548 30977 63430411
Hyponatraemia 86.50 13.34 166 27468 111734 63349654
Pain of skin 83.69 13.34 56 27578 11578 63449810
Facial pain 83.68 13.34 54 27580 10507 63450881
Contraindicated product administered 78.22 13.34 4 27630 217644 63243744
Vasculitis 77.67 13.34 64 27570 18145 63443243
Drug intolerance 74.61 13.34 21 27613 308640 63152748
Angina unstable 70.74 13.34 42 27592 7053 63454335
Parkinsonism 69.74 13.34 48 27586 10391 63450997
Systemic lupus erythematosus 68.75 13.34 6 27628 208912 63252476
Cardiac failure 68.58 13.34 132 27502 89010 63372378
Dementia 67.79 13.34 60 27574 18734 63442654
Drug interaction 67.35 13.34 236 27398 228895 63232493
Blindness 66.05 13.34 63 27571 21636 63439752
Angioedema 65.42 13.34 92 27542 47873 63413515
Melaena 65.04 13.34 73 27561 30292 63431096
Arthropathy 64.64 13.34 12 27622 234780 63226608
Eye pruritus 64.16 13.34 58 27576 18613 63442775
Rheumatoid arthritis 63.72 13.34 16 27618 253803 63207585
Diplopia 63.12 13.34 64 27570 23664 63437724
Infusion related reaction 62.57 13.34 15 27619 245506 63215882
Coronary arterial stent insertion 60.72 13.34 28 27606 2801 63458587
Cardiorenal syndrome 59.61 13.34 20 27614 855 63460533
Bradycardia 58.24 13.34 110 27524 73117 63388271
Muscle twitching 57.78 13.34 56 27578 19612 63441776
Tinnitus 57.21 13.34 74 27560 35554 63425834
Maternal exposure during pregnancy 56.95 13.34 13 27621 220049 63241339
Transient ischaemic attack 55.36 13.34 75 27559 37678 63423710
Atrial fibrillation 54.98 13.34 142 27492 116494 63344894
Cognitive disorder 54.88 13.34 92 27542 55723 63405665
Hyperkalaemia 54.17 13.34 90 27544 54113 63407275
Intentional product misuse 54.12 13.34 96 27538 60821 63400567
Glossodynia 54.09 13.34 7 27627 178869 63282519
Hallucination 52.10 13.34 89 27545 54728 63406660
Hypotension 51.58 13.34 245 27389 272359 63189029
Multiple drug therapy 51.12 13.34 27 27607 3619 63457769
Wound 50.31 13.34 6 27628 163257 63298131
Peripheral circulatory failure 50.01 13.34 18 27616 950 63460438
Mucosal erosion 48.90 13.34 20 27614 1496 63459892
Blood glucose increased 48.04 13.34 110 27524 83646 63377742
Fear of eating 47.88 13.34 14 27620 378 63461010
Dizziness 47.02 13.34 334 27300 429591 63031797
Therapeutic product effect decreased 46.91 13.34 13 27621 193174 63268214
Syncope 46.42 13.34 134 27500 117251 63344137
Toxic epidermal necrolysis 46.07 13.34 56 27578 25278 63436110
Joint swelling 44.74 13.34 46 27588 327620 63133768
Disturbance in attention 43.06 13.34 67 27567 38122 63423266
Swelling 40.69 13.34 36 27598 275342 63186046
Fall 40.12 13.34 300 27334 392034 63069354
Stomatitis 38.35 13.34 7 27627 138718 63322670
Nasopharyngitis 37.85 13.34 33 27601 254224 63207164
Hepatic enzyme increased 37.04 13.34 21 27613 202307 63259081
Renal impairment 37.01 13.34 103 27531 88252 63373136
Sinusitis 36.76 13.34 27 27607 226626 63234762
Chronic obstructive pulmonary disease 36.68 13.34 83 27551 62603 63398785
Myocardial ischaemia 36.62 13.34 36 27598 12823 63448565
Dermatitis exfoliative 36.22 13.34 25 27609 5434 63455954
Sodium retention 35.89 13.34 9 27625 133 63461255
Intestinal ischaemia 35.56 13.34 28 27606 7440 63453948
Anxiety disorder 35.30 13.34 22 27612 4028 63457360
Iron deficiency anaemia 34.46 13.34 43 27591 19926 63441462
Atrioventricular block first degree 34.05 13.34 27 27607 7246 63454142
Rash papular 34.05 13.34 38 27596 15664 63445724
Musculoskeletal stiffness 34.03 13.34 19 27615 184599 63276789
Anti-neutrophil cytoplasmic antibody positive vasculitis 33.79 13.34 19 27615 2880 63458508
Product use issue 33.57 13.34 28 27606 220492 63240896
Cerebrovascular accident 33.18 13.34 113 27521 107911 63353477
Amnesia 32.97 13.34 74 27560 55511 63405877
Neuroglycopenia 32.86 13.34 11 27623 467 63460921
Gastrointestinal haemorrhage 32.40 13.34 93 27541 81083 63380305
Blood cholesterol decreased 32.32 13.34 13 27621 931 63460457
Blood urea increased 32.17 13.34 48 27586 26331 63435057
Dry skin 31.82 13.34 74 27560 56813 63404575
Medication error 31.45 13.34 70 27564 52214 63409174
Rhabdomyolysis 31.25 13.34 63 27571 43888 63417500
Discomfort 31.17 13.34 17 27617 167357 63294031
Memory impairment 31.10 13.34 108 27526 104150 63357238
Exposure during pregnancy 30.15 13.34 15 27619 155532 63305856
Dehydration 29.32 13.34 151 27483 173203 63288185
Hyperthyroidism 29.25 13.34 34 27600 14639 63446749
Hypersensitivity 28.90 13.34 52 27582 292633 63168755
Impaired healing 28.72 13.34 5 27629 102537 63358851
Cholecystitis 27.97 13.34 34 27600 15343 63446045
Chronic kidney disease 27.55 13.34 61 27573 45337 63416051
Therapeutic product effect incomplete 27.52 13.34 10 27624 125046 63336342
Palpitations 27.11 13.34 109 27525 112661 63348727
International normalised ratio increased 26.63 13.34 61 27573 46364 63415024
Gastric polyps 25.96 13.34 17 27617 3388 63458000
Neutropenia 25.68 13.34 23 27611 174982 63286406
Intentional overdose 24.94 13.34 80 27554 74072 63387316
Product administration error 24.84 13.34 39 27595 22358 63439030
Stupor 24.72 13.34 18 27616 4257 63457131
Blood creatine increased 24.54 13.34 20 27614 5581 63455807
Dialysis 23.93 13.34 26 27608 10401 63450987
Hypomagnesaemia 23.87 13.34 44 27590 28693 63432695
Peptic ulcer 23.58 13.34 18 27616 4569 63456819
Pain 23.47 13.34 208 27426 740420 62720968
Vasodilatation 23.41 13.34 14 27620 2381 63459007
Blood potassium increased 23.31 13.34 34 27600 18275 63443113
Blood creatinine increased 21.18 13.34 85 27549 87759 63373629
Upper gastrointestinal haemorrhage 21.14 13.34 33 27601 18819 63442569
Dyspnoea 21.05 13.34 404 27230 660909 62800479
Ill-defined disorder 20.79 13.34 5 27629 81750 63379638
Febrile neutropenia 20.67 13.34 13 27621 118436 63342952
Mitral valve stenosis 20.23 13.34 10 27624 1167 63460221
Blood cholesterol increased 19.89 13.34 8 27626 94024 63367364
Urinary retention 19.85 13.34 42 27592 30259 63431129
Visual impairment 19.79 13.34 81 27553 84365 63377023
Electrocardiogram QRS complex prolonged 19.52 13.34 18 27616 5920 63455468
Gastroenteritis bacterial 19.38 13.34 7 27627 373 63461015
Hyperparathyroidism 19.21 13.34 13 27621 2736 63458652
Nodal rhythm 19.18 13.34 11 27623 1732 63459656
Product residue present 19.12 13.34 15 27619 3964 63457424
Cardiac failure acute 18.87 13.34 22 27612 9501 63451887
Muscle injury 18.71 13.34 3 27631 65342 63396046
Drug dependence 18.49 13.34 36 27598 24447 63436941
Conjunctival discolouration 18.29 13.34 5 27629 105 63461283
Sinus arrest 18.04 13.34 11 27623 1938 63459450
Vitamin D deficiency 17.98 13.34 26 27608 13866 63447522
Labelled drug-drug interaction issue 17.88 13.34 9 27625 1092 63460296
Hiatus hernia 17.85 13.34 33 27601 21561 63439827
Acid base balance abnormal 17.74 13.34 6 27628 263 63461125
Micturition disorder 17.73 13.34 12 27622 2526 63458862
Corneal abrasion 17.70 13.34 9 27625 1115 63460273
Diabetes mellitus inadequate control 17.70 13.34 27 27607 15099 63446289
Psoriatic arthropathy 17.46 13.34 9 27625 91511 63369877
Infection 17.43 13.34 47 27587 229126 63232262
Cardiac disorder 17.24 13.34 55 27579 50761 63410627
Shock 17.12 13.34 34 27600 23429 63437959
Initial insomnia 17.09 13.34 17 27617 6140 63455248
Glomerular filtration rate abnormal 17.06 13.34 8 27626 831 63460557
Eosinophilic granulomatosis with polyangiitis 16.85 13.34 11 27623 2181 63459207
Fibromyalgia 16.75 13.34 7 27627 80413 63380975
Osteoporosis 16.74 13.34 59 27575 57279 63404109
Blood pressure decreased 16.55 13.34 64 27570 64958 63396430
Blood loss anaemia 16.53 13.34 20 27614 8981 63452407
Gastrointestinal tract mucosal pigmentation 16.26 13.34 7 27627 595 63460793
Tuberculosis of central nervous system 16.23 13.34 6 27628 342 63461046
Acute coronary syndrome 16.20 13.34 21 27613 10105 63451283
Arthritis 16.10 13.34 16 27618 115905 63345483
Coronary artery bypass 16.07 13.34 11 27623 2358 63459030
Metastatic neoplasm 16.06 13.34 14 27620 4281 63457107
Haemorrhoids 16.04 13.34 32 27602 22118 63439270
Tachycardia 16.02 13.34 97 27537 118059 63343329
Colitis microscopic 15.94 13.34 20 27614 9319 63452069
Irritable bowel syndrome 15.88 13.34 8 27626 82404 63378984
Off label use 15.83 13.34 203 27431 674259 62787129
Abdominal pain upper 15.77 13.34 148 27486 206296 63255092
Glomerulonephritis rapidly progressive 15.76 13.34 8 27626 987 63460401
Cardiac failure chronic 15.72 13.34 14 27620 4404 63456984
Bradykinesia 15.66 13.34 15 27619 5173 63456215
Lupus myocarditis 15.66 13.34 4 27630 64 63461324
Pulmonary oedema 15.62 13.34 56 27578 54817 63406571
Drug hypersensitivity 15.50 13.34 76 27558 310611 63150777
Dermatitis atopic 15.30 13.34 20 27614 9704 63451684
Completed suicide 15.17 13.34 25 27609 145648 63315740
Post procedural haemorrhage 15.12 13.34 18 27616 7946 63453442
Mitral valve incompetence 15.03 13.34 29 27605 19565 63441823
Renal failure 14.95 13.34 95 27539 117557 63343831
Schizophrenia 14.93 13.34 20 27614 9932 63451456
Procedural haemorrhage 14.82 13.34 11 27623 2677 63458711
Cutaneous lupus erythematosus 14.73 13.34 11 27623 2701 63458687
Anal haemorrhage 14.69 13.34 10 27624 2126 63459262
Electrolyte imbalance 14.53 13.34 29 27605 20047 63441341
Muscular weakness 14.45 13.34 97 27537 122256 63339132
Knee arthroplasty 14.41 13.34 3 27631 54203 63407185
Arteriosclerosis coronary artery 14.40 13.34 18 27616 8355 63453033
Hyperhidrosis 14.28 13.34 88 27546 107748 63353640
Gastrointestinal tract mucosal discolouration 14.12 13.34 3 27631 20 63461368
Electrocardiogram QT prolonged 13.87 13.34 57 27577 59473 63401915
Feeling abnormal 13.73 13.34 111 27523 148281 63313107
Motor dysfunction 13.72 13.34 20 27614 10741 63450647
Urticaria 13.37 13.34 33 27601 165769 63295619
Lethargy 13.34 13.34 54 27580 55953 63405435

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 320.66 12.82 460 30364 120625 34805482
Cardiac failure congestive 283.91 12.82 358 30466 82912 34843195
Cardiospasm 189.77 12.82 66 30758 1522 34924585
Angina pectoris 181.46 12.82 178 30646 31185 34894922
Palmoplantar keratoderma 172.79 12.82 65 30759 1888 34924219
Acute myocardial infarction 170.35 12.82 223 30601 53496 34872611
Pruritus genital 161.65 12.82 64 30760 2140 34923967
Sleep terror 158.52 12.82 64 30760 2254 34923853
Chest pain 156.50 12.82 345 30479 126417 34799690
Tension headache 154.58 12.82 68 30756 2974 34923133
Atrial tachycardia 139.77 12.82 67 30757 3578 34922529
Carotid artery occlusion 138.18 12.82 67 30757 3670 34922437
Coronary artery disease 137.06 12.82 190 30634 48115 34877992
Facial pain 132.73 12.82 65 30759 3639 34922468
Anosmia 130.54 12.82 66 30758 3958 34922149
Immunisation 129.61 12.82 45 30779 1032 34925075
Pain of skin 112.41 12.82 69 30755 6040 34920067
Drug ineffective 108.66 12.82 147 30677 456604 34469503
Angina unstable 96.60 12.82 81 30743 11572 34914535
Eye pruritus 94.91 12.82 67 30757 7422 34918685
Ventricular tachycardia 94.70 12.82 117 30707 26462 34899645
Muscle twitching 90.40 12.82 74 30750 10224 34915883
Lip swelling 88.75 12.82 89 30735 15991 34910116
Subarachnoid haemorrhage 86.96 12.82 79 30745 12556 34913551
Vasculitis 82.43 12.82 73 30751 11223 34914884
Hypotension 81.17 12.82 398 30426 221251 34704856
Pericarditis 78.56 12.82 72 30752 11573 34914534
Dizziness 76.18 12.82 387 30437 218134 34707973
Cardiac failure 70.28 12.82 208 30616 91040 34835067
Hallucination 65.46 12.82 142 30682 51356 34874751
Blindness 61.65 12.82 71 30753 14915 34911192
Transient ischaemic attack 60.13 12.82 96 30728 27517 34898590
Cognitive disorder 60.09 12.82 98 30726 28595 34897512
Off label use 59.41 12.82 182 30642 419342 34506765
Rash papular 58.77 12.82 58 30766 10220 34915887
Syncope 56.28 12.82 193 30631 91258 34834849
Presyncope 55.55 12.82 76 30748 18983 34907124
Diplopia 54.99 12.82 71 30753 16772 34909335
Drug abuse 53.68 12.82 11 30813 99085 34827022
Migraine 52.92 12.82 71 30753 17407 34908700
Dry skin 48.90 12.82 94 30730 31193 34894914
Amnesia 48.05 12.82 85 30739 26478 34899629
Myocardial ischaemia 47.12 12.82 67 30757 17341 34908766
Coronary arterial stent insertion 45.62 12.82 34 30790 4095 34922012
Palpitations 44.92 12.82 105 30719 39881 34886226
Dyspnoea 43.52 12.82 515 30309 376267 34549840
Disturbance in attention 43.08 12.82 80 30744 25865 34900242
Blood glucose increased 42.96 12.82 143 30681 66575 34859532
Anti-neutrophil cytoplasmic antibody positive vasculitis 41.56 12.82 19 30805 910 34925197
Tinnitus 41.15 12.82 68 30756 20050 34906057
Alopecia 39.07 12.82 74 30750 24281 34901826
Product use in unapproved indication 39.07 12.82 28 30796 117471 34808636
Visual impairment 38.03 12.82 92 30732 35710 34890397
Venous pressure jugular increased 37.79 12.82 17 30807 784 34925323
Blood potassium increased 36.80 12.82 58 30766 16437 34909670
Febrile neutropenia 36.61 12.82 40 30784 136809 34789298
Angioedema 36.50 12.82 93 30731 37281 34888826
Bradycardia 36.21 12.82 147 30677 75271 34850836
International normalised ratio increased 35.55 12.82 107 30717 47220 34878887
Left atrial dilatation 32.83 12.82 21 30803 1975 34924132
Gastrointestinal haemorrhage 32.33 12.82 159 30665 88318 34837789
Atrial fibrillation 30.82 12.82 199 30625 122194 34803913
Completed suicide 30.57 12.82 25 30799 98143 34827964
Ventricular dysfunction 30.02 12.82 26 30798 3879 34922228
Memory impairment 29.81 12.82 95 30729 43223 34882884
Haematocrit increased 29.34 12.82 20 30804 2093 34924014
Malignant neoplasm progression 29.23 12.82 21 30803 88025 34838082
Chest discomfort 29.18 12.82 110 30714 54420 34871687
Venous pressure jugular decreased 28.95 12.82 7 30817 40 34926067
Drug interaction 28.75 12.82 315 30509 225631 34700476
Upper gastrointestinal haemorrhage 28.64 12.82 67 30757 25451 34900656
Acute kidney injury 28.42 12.82 401 30423 304587 34621520
Mucosal dryness 26.98 12.82 16 30808 1315 34924792
Lupus pneumonitis 26.69 12.82 7 30817 58 34926049
Peripheral swelling 25.47 12.82 134 30690 76407 34849700
Arteriospasm coronary 24.95 12.82 22 30802 3360 34922747
Hyperhidrosis 24.83 12.82 132 30692 75560 34850547
Dehydration 24.43 12.82 197 30627 129772 34796335
Muscular weakness 23.83 12.82 127 30697 72770 34853337
Neutropenia 23.53 12.82 66 30758 156712 34769395
Wrong patient received product 23.13 12.82 19 30805 2635 34923472
Rhabdomyolysis 23.13 12.82 120 30704 68043 34858064
Malaise 23.13 12.82 258 30566 185567 34740540
Heart rate increased 21.96 12.82 90 30734 46253 34879854
Glomerular filtration rate decreased 21.55 12.82 40 30784 12921 34913186
Mucosal inflammation 21.50 12.82 4 30820 38618 34887489
Haemoglobin increased 20.91 12.82 20 30804 3389 34922718
Cardiac failure chronic 20.84 12.82 30 30794 7849 34918258
Toxicity to various agents 20.43 12.82 99 30725 200263 34725844
Pulmonary oedema 19.97 12.82 89 30735 47440 34878667
Hypovolaemia 19.95 12.82 32 30792 9202 34916905
Feeling abnormal 19.20 12.82 108 30716 63127 34862980
Rheumatoid arthritis 19.19 12.82 5 30819 38233 34887874
Hirsutism 19.12 12.82 7 30817 188 34925919
Nodal arrhythmia 18.97 12.82 11 30813 867 34925240
Orthostatic hypotension 18.89 12.82 58 30766 25861 34900246
Gravitational oedema 18.74 12.82 10 30814 670 34925437
Excessive cerumen production 18.62 12.82 8 30816 330 34925777
Coronary artery bypass 18.13 12.82 22 30802 4880 34921227
Oedema peripheral 18.04 12.82 173 30651 119639 34806468
Blood pressure systolic decreased 17.95 12.82 21 30803 4482 34921625
Abdominal pain upper 17.83 12.82 116 30708 71374 34854733
Nasal crusting 17.70 12.82 8 30816 373 34925734
Mast cell activation syndrome 17.43 12.82 7 30817 243 34925864
Drug reaction with eosinophilia and systemic symptoms 17.18 12.82 4 30820 33008 34893099
Pterygium 17.18 12.82 6 30818 140 34925967
General physical health deterioration 17.10 12.82 57 30767 128212 34797895
Cardiac failure acute 16.80 12.82 32 30792 10538 34915569
Ischaemic cardiomyopathy 16.42 12.82 24 30800 6365 34919742
Nitritoid reaction 16.38 12.82 4 30820 24 34926083
Stent placement 15.94 12.82 21 30803 5057 34921050
Infusion related reaction 15.91 12.82 14 30810 53043 34873064
Pancytopenia 15.84 12.82 38 30786 95119 34830988
Pyrexia 15.84 12.82 203 30621 332810 34593297
Arrhythmia 15.76 12.82 68 30756 35740 34890367
Therapeutic product effect incomplete 15.57 12.82 13 30811 50528 34875579
Electrocardiogram ST segment elevation 15.43 12.82 21 30803 5217 34920890
Septic arthritis staphylococcal 15.39 12.82 8 30816 508 34925599
Arteriosclerosis coronary artery 15.36 12.82 34 30790 12451 34913656
Seizure 15.09 12.82 45 30779 104812 34821295
Linear IgA disease 14.93 12.82 12 30812 1614 34924493
Infection 14.59 12.82 37 30787 90878 34835229
Acute coronary syndrome 14.58 12.82 35 30789 13510 34912597
Tachycardia 14.58 12.82 126 30698 84646 34841461
Rash 14.56 12.82 126 30698 222626 34703481
Contusion 14.46 12.82 67 30757 36297 34889810
Condition aggravated 14.27 12.82 105 30719 192091 34734016
Prostate cancer 13.76 12.82 9 30815 39640 34886467
Encephalopathy 13.70 12.82 7 30817 35312 34890795
Abdominal discomfort 13.66 12.82 95 30729 59740 34866367
Neutrophil count decreased 13.58 12.82 15 30809 51089 34875018
Eczema nummular 13.56 12.82 5 30819 137 34925970
Faeces discoloured 13.47 12.82 36 30788 14842 34911265
Injection site pain 13.34 12.82 9 30815 38996 34887111
Bundle branch block left 13.30 12.82 21 30803 5958 34920149
Drug intolerance 13.23 12.82 20 30804 59550 34866557
Treatment failure 13.20 12.82 13 30811 46684 34879423
Incarcerated hernia 12.92 12.82 5 30819 157 34925950

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 708.51 12.06 732 51814 183397 79508445
Cardiac failure congestive 525.57 12.06 554 51992 141848 79549994
Cardiospasm 343.60 12.06 115 52431 3186 79688656
Acute myocardial infarction 343.01 12.06 332 52214 76704 79615138
Palmoplantar keratoderma 326.41 12.06 114 52432 3602 79688240
Pruritus genital 305.44 12.06 114 52432 4372 79687470
Sleep terror 302.48 12.06 113 52433 4345 79687497
Angina pectoris 270.76 12.06 244 52302 51488 79640354
Atrial tachycardia 270.38 12.06 119 52427 7014 79684828
Tension headache 269.13 12.06 119 52427 7092 79684750
Coronary artery disease 263.29 12.06 267 52279 65207 79626635
Carotid artery occlusion 259.27 12.06 118 52428 7529 79684313
Chest pain 253.46 12.06 568 51978 281736 79410106
Subarachnoid haemorrhage 239.77 12.06 167 52379 24298 79667544
Anosmia 236.90 12.06 116 52430 8728 79683114
Immunisation 223.58 12.06 75 52471 2092 79689750
Facial pain 200.47 12.06 116 52430 12234 79679608
Drug ineffective 196.30 12.06 256 52290 1080657 78611185
Pain of skin 192.47 12.06 120 52426 14493 79677349
Ventricular tachycardia 190.82 12.06 183 52363 41752 79650090
Angina unstable 174.17 12.06 118 52428 16409 79675433
Lip swelling 166.54 12.06 168 52378 40743 79651099
Vasculitis 154.69 12.06 130 52416 24972 79666870
Eye pruritus 151.01 12.06 118 52428 20452 79671390
Muscle twitching 145.94 12.06 125 52421 24639 79667203
Blindness 127.48 12.06 123 52423 28260 79663582
Acute kidney injury 124.02 12.06 671 51875 518733 79173109
Diplopia 122.80 12.06 130 52416 33336 79658506
Hypotension 122.64 12.06 594 51952 439723 79252119
Hallucination 122.43 12.06 210 52336 85535 79606307
Cardiac failure 116.36 12.06 291 52255 154551 79537291
Coronary arterial stent insertion 114.97 12.06 63 52483 5981 79685861
Cognitive disorder 114.27 12.06 182 52364 69744 79622098
Transient ischaemic attack 111.75 12.06 155 52391 52540 79639302
Dizziness 107.22 12.06 652 51894 525789 79166053
Drug intolerance 100.74 12.06 25 52521 264094 79427748
Syncope 96.01 12.06 298 52248 179151 79512691
Rash papular 94.71 12.06 93 52453 21823 79670019
Angioedema 94.13 12.06 175 52371 75860 79615982
Rheumatoid arthritis 91.54 12.06 14 52532 208456 79483386
Bradycardia 90.75 12.06 244 52302 135313 79556529
Tinnitus 90.42 12.06 128 52418 44205 79647637
Disturbance in attention 89.64 12.06 137 52409 50664 79641178
Atrial fibrillation 86.57 12.06 307 52239 197579 79494263
Synovitis 85.91 12.06 3 52543 150731 79541111
Blood glucose increased 85.20 12.06 215 52331 114760 79577082
Dry skin 83.54 12.06 156 52390 67839 79624003
Drug interaction 83.01 12.06 512 52034 414671 79277171
Infusion related reaction 80 12.06 26 52520 230211 79461631
Sinusitis 75.51 12.06 18 52528 195483 79496359
Arthropathy 75.28 12.06 13 52533 177098 79514744
Gastrointestinal haemorrhage 73.22 12.06 239 52307 147480 79544362
Amnesia 72.93 12.06 141 52405 62916 79628926
Off label use 71.81 12.06 331 52215 906884 78784958
Treatment failure 71.40 12.06 13 52533 170473 79521369
Myocardial ischaemia 71.22 12.06 86 52460 25433 79666409
Hyperkalaemia 70.68 12.06 200 52346 114198 79577644
Contraindicated product administered 70.49 12.06 10 52536 157528 79534314
Anti-neutrophil cytoplasmic antibody positive vasculitis 68.54 12.06 38 52508 3691 79688151
Hypoglycaemia 68.10 12.06 183 52363 101411 79590431
Rhabdomyolysis 65.38 12.06 182 52364 102949 79588893
Palpitations 64.68 12.06 207 52339 126403 79565439
Hyponatraemia 63.78 12.06 259 52287 177589 79514253
Melaena 63.03 12.06 130 52416 60760 79631082
Therapeutic product effect decreased 61.51 12.06 16 52530 163847 79527995
Dehydration 58.58 12.06 320 52226 247867 79443975
Blood potassium increased 57.45 12.06 83 52463 29192 79662650
Memory impairment 56.45 12.06 182 52364 111552 79580290
Joint swelling 55.56 12.06 65 52481 288581 79403261
International normalised ratio increased 54.17 12.06 150 52396 84571 79607271
Stomatitis 53.81 12.06 15 52531 146742 79545100
Intentional product misuse 53.61 12.06 161 52385 95004 79596838
Febrile neutropenia 52.48 12.06 45 52501 230954 79460888
Maternal exposure during pregnancy 51.88 12.06 13 52533 136525 79555317
Presyncope 51.43 12.06 95 52451 40959 79650883
Fear of eating 51.30 12.06 17 52529 456 79691386
Systemic lupus erythematosus 51.23 12.06 9 52537 121140 79570702
Completed suicide 50.99 12.06 52 52494 245715 79446127
Drug abuse 50.43 12.06 22 52524 162669 79529173
Dyspnoea 49.69 12.06 816 51730 856209 78835633
Upper gastrointestinal haemorrhage 49.65 12.06 94 52452 41286 79650556
Wound 48.33 12.06 9 52537 116170 79575672
Visual impairment 48.29 12.06 152 52394 91979 79599863
Nasopharyngitis 45.88 12.06 60 52486 253821 79438021
Product use in unapproved indication 44.39 12.06 60 52486 250299 79441543
Mucosal erosion 43.64 12.06 24 52522 2294 79689548
Peripheral circulatory failure 43.04 12.06 19 52527 1127 79690715
Multiple drug therapy 42.68 12.06 29 52517 4049 79687793
Therapeutic product effect incomplete 42.58 12.06 20 52526 141625 79550217
Neutropenia 42.43 12.06 78 52468 287632 79404210
Musculoskeletal stiffness 42.36 12.06 32 52514 174976 79516866
Swelling 40.41 12.06 50 52496 216661 79475181
Cardiac failure chronic 40.38 12.06 43 52503 11092 79680750
Hyperhidrosis 40.31 12.06 202 52344 151290 79540552
Product use issue 39.56 12.06 48 52498 209774 79482068
Pemphigus 38.77 12.06 9 52537 99573 79592269
Dementia 38.64 12.06 63 52483 24596 79667246
Coronary artery bypass 38.59 12.06 32 52514 6030 79685812
Infection 37.93 12.06 63 52483 241649 79450193
Muscular weakness 37.73 12.06 207 52339 160522 79531320
Cardiorenal syndrome 37.12 12.06 19 52527 1570 79690272
Ventricular dysfunction 36.70 12.06 31 52515 5992 79685850
Glossodynia 35.29 12.06 12 52534 103325 79588517
Cardiac failure acute 34.73 12.06 52 52494 18877 79672965
Pulmonary oedema 34.41 12.06 132 52414 88122 79603720
Left atrial dilatation 34.38 12.06 23 52523 3130 79688712
Venous pressure jugular increased 34.17 12.06 17 52529 1323 79690519
Impaired healing 33.97 12.06 8 52538 87647 79604195
Renal impairment 33.60 12.06 198 52348 157585 79534257
Mucosal inflammation 33.33 12.06 5 52541 75575 79616267
Hypersensitivity 32.84 12.06 78 52468 262161 79429681
Exposure during pregnancy 32.42 12.06 13 52533 101119 79590723
Helicobacter infection 32.18 12.06 4 52542 69700 79622142
Feeling abnormal 31.50 12.06 196 52350 159003 79532839
Atrioventricular block first degree 31.48 12.06 40 52506 12451 79679391
Dermatitis exfoliative 31.04 12.06 37 52509 10792 79681050
Arthritis 30.47 12.06 19 52527 114861 79576981
Psoriatic arthropathy 30.46 12.06 7 52539 77992 79613850
Discomfort 30.35 12.06 23 52523 125594 79566248
Glomerular filtration rate decreased 30.29 12.06 54 52492 22648 79669194
Ischaemic cardiomyopathy 30.20 12.06 31 52515 7664 79684178
Arteriosclerosis coronary artery 29.95 12.06 47 52499 17769 79674073
Blood creatine increased 29.93 12.06 34 52512 9421 79682421
Parkinsonism 29.63 12.06 45 52501 16539 79675303
Migraine 29.43 12.06 125 52421 87368 79604474
Sodium retention 29.28 12.06 9 52537 188 79691654
Malignant neoplasm progression 29.07 12.06 28 52518 135962 79555880
Fibromyalgia 28.97 12.06 4 52542 64336 79627506
Cerebrovascular accident 28.75 12.06 188 52358 155104 79536738
Tachycardia 28.65 12.06 208 52338 177560 79514282
Injection site pain 28.62 12.06 26 52520 129812 79562030
Gastric polyps 28.59 12.06 22 52524 3725 79688117
General physical health deterioration 28.38 12.06 90 52456 275148 79416694
Neuroglycopenia 28.27 12.06 11 52535 473 79691369
Hepatic enzyme increased 27.35 12.06 49 52497 182561 79509281
Drug reaction with eosinophilia and systemic symptoms 26.67 12.06 5 52541 64239 79627603
Lupus pneumonitis 26.53 12.06 7 52539 82 79691760
Gravitational oedema 26.50 12.06 16 52530 1823 79690019
Venous pressure jugular decreased 26.38 12.06 7 52539 84 79691758
Arteriospasm coronary 26.26 12.06 27 52519 6689 79685153
Blood urea increased 26.02 12.06 81 52465 48709 79643133
Irritable bowel syndrome 25.50 12.06 5 52541 62236 79629606
Blood pressure decreased 25.30 12.06 131 52415 99335 79592507
Chronic obstructive pulmonary disease 24.93 12.06 117 52429 85302 79606540
Haemoglobin increased 24.61 12.06 25 52521 6107 79685735
Acute coronary syndrome 24.11 12.06 47 52499 21086 79670756
Osteoarthritis 23.76 12.06 14 52532 87295 79604547
Rash 23.39 12.06 256 52290 578102 79113740
Urticaria 23.24 12.06 55 52491 185146 79506696
Bundle branch block left 23.11 12.06 33 52513 11480 79680362
Heart rate increased 22.86 12.06 147 52399 120577 79571265
Malaise 22.79 12.06 451 52095 489418 79202424
Orthostatic hypotension 22.71 12.06 85 52461 56079 79635763
Wrong patient received product 22.61 12.06 21 52525 4597 79687245
Condition aggravated 22.23 12.06 217 52329 500907 79190935
Muscle injury 21.91 12.06 3 52543 48558 79643284
Rectal haemorrhage 21.90 12.06 104 52442 76196 79615646
Ill-defined disorder 21.89 12.06 8 52538 65867 79625975
Arrhythmia 21.75 12.06 89 52457 61183 79630659
Abdominal pain upper 21.57 12.06 234 52312 223585 79468257
Haematocrit increased 21.03 12.06 19 52527 4015 79687827
Blood loss anaemia 20.85 12.06 37 52509 15461 79676381
Atrioventricular block 20.83 12.06 35 52511 14006 79677836
Fall 20.40 12.06 442 52104 487187 79204655
Toxicity to various agents 20.21 12.06 179 52367 421361 79270481
Cholecystitis 20.19 12.06 45 52501 22167 79669675
Toxic epidermal necrolysis 20.17 12.06 70 52476 44511 79647331
Faeces discoloured 20.04 12.06 53 52493 29074 79662768
Oedema peripheral 19.98 12.06 254 52292 252034 79439808
Oxygen saturation decreased 19.89 12.06 34 52512 129013 79562829
Prinzmetal angina 19.85 12.06 13 52533 1707 79690135
Blood cholesterol decreased 19.82 12.06 13 52533 1712 79690130
Neutrophil count decreased 19.33 12.06 20 52526 93939 79597903
Pain 19.31 12.06 337 52209 703465 78988377
Injection site erythema 19.30 12.06 14 52532 78183 79613659
Chest discomfort 19.15 12.06 156 52390 137888 79553954
Mitral valve stenosis 18.67 12.06 11 52535 1199 79690643
Coronary artery occlusion 18.63 12.06 35 52511 15280 79676562
Weight increased 18.54 12.06 107 52439 277279 79414563
Sinus bradycardia 18.46 12.06 47 52499 25200 79666642
Blood creatinine increased 18.26 12.06 169 52377 154888 79536954
Electrocardiogram ST segment elevation 18.24 12.06 25 52521 8372 79683470
Hypomagnesaemia 18.14 12.06 70 52476 46841 79645001
Drug hypersensitivity 18.06 12.06 119 52427 298797 79393045
Glomerular filtration rate abnormal 17.92 12.06 12 52534 1636 79690206
Sleep disorder 17.89 12.06 18 52528 85659 79606183
Pruritus 17.89 12.06 362 52184 394286 79297556
Neoplasm progression 17.65 12.06 6 52540 51676 79640166
Excessive cerumen production 17.61 12.06 9 52537 741 79691101
Gastrointestinal tract mucosal pigmentation 17.40 12.06 10 52536 1040 79690802
Hypovolaemia 17.40 12.06 37 52509 17654 79674188
Ventricular hypertrophy 17.14 12.06 22 52524 6916 79684926
Inflammation 17.08 12.06 22 52524 93731 79598111
Mucosal dryness 17.07 12.06 16 52530 3543 79688299
Ventricular fibrillation 17.02 12.06 53 52493 31873 79659969
Intestinal ischaemia 16.98 12.06 31 52515 13239 79678603
Nitritoid reaction 16.88 12.06 4 52542 29 79691813
COVID-19 16.67 12.06 168 52378 157506 79534336
Knee arthroplasty 16.65 12.06 4 52542 43244 79648598
Vasodilatation 16.58 12.06 15 52531 3176 79688666
Disease progression 16.50 12.06 64 52482 184298 79507544
Therapeutic response decreased 16.46 12.06 12 52534 66841 79625001
Nasal crusting 16.34 12.06 8 52538 601 79691241
Injection site reaction 16.05 12.06 8 52538 54777 79637065
Shock 16.05 12.06 64 52482 43484 79648358
Upper respiratory tract infection 15.99 12.06 22 52524 91146 79600696
Corneal abrasion 15.87 12.06 10 52536 1229 79690613
Mitral valve incompetence 15.77 12.06 48 52498 28517 79663325
Pericarditis 15.67 12.06 120 52426 104116 79587726
Gastroenteritis bacterial 15.44 12.06 7 52539 442 79691400
Conjunctival discolouration 15.31 12.06 5 52541 128 79691714
White blood cell count decreased 15.21 12.06 68 52478 188220 79503622
Liver function test abnormal 15.09 12.06 83 52463 64392 79627450
Cardiac disorder 14.95 12.06 84 52462 65673 79626169
Renal failure 14.93 12.06 200 52346 200768 79491074
Hyperthyroidism 14.86 12.06 40 52506 22169 79669673
Weight decreased 14.82 12.06 156 52390 355042 79336800
Electrocardiogram QRS complex prolonged 14.75 12.06 26 52520 10807 79681035
Gastritis erosive 14.73 12.06 26 52520 10821 79681021
Arteriosclerosis 14.45 12.06 35 52511 18192 79673650
Blood pressure systolic decreased 14.33 12.06 26 52520 11050 79680792
Stupor 14.24 12.06 20 52526 6852 79684990
Septic arthritis staphylococcal 14.18 12.06 8 52538 803 79691039
Dialysis 14.16 12.06 35 52511 18427 79673415
Chronic kidney disease 14.06 12.06 83 52463 66071 79625771
Bronchitis 13.96 12.06 42 52504 130602 79561240
Hypercalcaemia 13.95 12.06 4 52542 38426 79653416
Lower gastrointestinal haemorrhage 13.91 12.06 32 52514 16093 79675749
Pyrexia 13.86 12.06 341 52205 678368 79013474
Nodal arrhythmia 13.77 12.06 11 52535 1967 79689875
Oliguria 13.67 12.06 32 52514 16277 79675565
Hiatus hernia 13.65 12.06 40 52506 23272 79668570
Sudden cardiac death 13.59 12.06 17 52529 5208 79686634
Stent placement 13.55 12.06 19 52527 6501 79685341
Acid base balance abnormal 13.43 12.06 6 52540 366 79691476
Subacute cutaneous lupus erythematosus 13.35 12.06 14 52532 3547 79688295
Multiple sclerosis relapse 13.33 12.06 7 52539 46526 79645316
Glomerulonephritis rapidly progressive 13.29 12.06 10 52536 1638 79690204
Atrioventricular block complete 13.28 12.06 32 52514 16578 79675264
Stress 13.18 12.06 20 52526 79592 79612250
Palmar-plantar erythrodysaesthesia syndrome 12.88 12.06 3 52543 33131 79658711
Vascular stent thrombosis 12.88 12.06 14 52532 3696 79688146
Peripheral arterial occlusive disease 12.80 12.06 21 52525 8237 79683605
Leukopenia 12.78 12.06 37 52509 116476 79575366
Peptic ulcer 12.73 12.06 18 52528 6205 79685637
Lupus myocarditis 12.69 12.06 4 52542 91 79691751
Hyperparathyroidism 12.68 12.06 13 52533 3211 79688631
Asthma 12.67 12.06 46 52500 135049 79556793
Pneumonectomy 12.57 12.06 4 52542 94 79691748
Hip arthroplasty 12.47 12.06 4 52542 35752 79656090
Loss of personal independence in daily activities 12.44 12.06 31 52515 102549 79589293
Peripheral swelling 12.43 12.06 248 52298 269369 79422473
Labelled drug-drug interaction issue 12.35 12.06 9 52537 1404 79690438
Colitis microscopic 12.35 12.06 24 52522 10744 79681098
Paraesthesia 12.33 12.06 67 52479 176256 79515586
Blood creatine phosphokinase increased 12.21 12.06 80 52466 66010 79625832
Injection site swelling 12.21 12.06 8 52538 47124 79644718

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01DA14 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
VASODILATORS USED IN CARDIAC DISEASES
Organic nitrates
FDA CS M0014874 Nitrates
FDA PE N0000009909 Vasodilation
FDA EPC N0000175415 Nitrate Vasodilator
MeSH PA D002317 Cardiovascular Agents
MeSH PA D020030 Nitric Oxide Donors
MeSH PA D014665 Vasodilator Agents
CHEBI has role CHEBI:35620 vasodilator agents
CHEBI has role CHEBI:50566 nitric oxide generators

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Angina pectoris indication 194828000
Angina Pectoris Prevention indication
Chronic heart failure off-label use 48447003
Prevention of Bleeding Esophageal Varices off-label use
Myocardial infarction contraindication 22298006 DOID:5844
Hyperthyroidism contraindication 34486009 DOID:7998
Low blood pressure contraindication 45007003
Injury of head contraindication 82271004
Increased intestinal motility contraindication 102624003
Hypertrophic cardiomyopathy contraindication 233873004 DOID:11984
Anemia contraindication 271737000 DOID:2355
Cerebral hemorrhage contraindication 274100004
Malabsorption States contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Soluble guanylate cyclase Enzyme ACTIVATOR CHEMBL CHEMBL
Atrial natriuretic peptide receptor 1 Enzyme WOMBAT-PK

External reference:

IDSource
4020224 VUID
N0000179163 NUI
D00630 KEGG_DRUG
4020224 VANDF
C0064079 UMLSCUI
CHEBI:6062 CHEBI
CHEMBL1311 ChEMBL_ID
DB01020 DRUGBANK_ID
27661 PUBCHEM_CID
5177 INN_ID
C030397 MESH_SUPPLEMENTAL_RECORD_UI
7052 IUPHAR_LIGAND_ID
LX1OH63030 UNII
28004 RXNORM
4935 MMSL
6257 MMSL
d00269 MMSL
003639 NDDF
108484003 SNOMEDCT_US
386854005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Isosorbide Mononitrate HUMAN PRESCRIPTION DRUG LABEL 1 0228-2620 TABLET 20 mg ORAL ANDA 21 sections
Isosorbide Mononitrate HUMAN PRESCRIPTION DRUG LABEL 1 0228-2620 TABLET 20 mg ORAL ANDA 21 sections
Isosorbide Mononitrate HUMAN PRESCRIPTION DRUG LABEL 1 0228-2631 TABLET 10 mg ORAL ANDA 21 sections
Isosorbide Mononitrate HUMAN PRESCRIPTION DRUG LABEL 1 0228-2631 TABLET 10 mg ORAL ANDA 21 sections
ISOSORBIDE MONONITRATE HUMAN PRESCRIPTION DRUG LABEL 1 0615-7767 TABLET, EXTENDED RELEASE 30 mg ORAL ANDA 12 sections
ISOSORBIDE MONONITRATE HUMAN PRESCRIPTION DRUG LABEL 1 0615-7768 TABLET, EXTENDED RELEASE 60 mg ORAL ANDA 20 sections
ISOSORBIDE MONONITRATE HUMAN PRESCRIPTION DRUG LABEL 1 0615-8043 TABLET 30 mg ORAL ANDA 23 sections
ISOSORBIDE MONONITRATE HUMAN PRESCRIPTION DRUG LABEL 1 0615-8043 TABLET 30 mg ORAL ANDA 23 sections
ISOSORBIDE MONONITRATE HUMAN PRESCRIPTION DRUG LABEL 1 0615-8044 TABLET 60 mg ORAL ANDA 23 sections
ISOSORBIDE MONONITRATE HUMAN PRESCRIPTION DRUG LABEL 1 0615-8044 TABLET 60 mg ORAL ANDA 23 sections
ISOSORBIDE MONONITRATE HUMAN PRESCRIPTION DRUG LABEL 1 0904-6449 TABLET, EXTENDED RELEASE 30 mg ORAL ANDA 12 sections
ISOSORBIDE MONONITRATE HUMAN PRESCRIPTION DRUG LABEL 1 0904-6449 TABLET, EXTENDED RELEASE 30 mg ORAL ANDA 12 sections
ISOSORBIDE MONONITRATE HUMAN PRESCRIPTION DRUG LABEL 1 0904-6450 TABLET, EXTENDED RELEASE 60 mg ORAL ANDA 12 sections
ISOSORBIDE MONONITRATE HUMAN PRESCRIPTION DRUG LABEL 1 0904-6450 TABLET, EXTENDED RELEASE 60 mg ORAL ANDA 12 sections
ISOSORBIDE MONONITRATE HUMAN PRESCRIPTION DRUG LABEL 1 0904-6451 TABLET, EXTENDED RELEASE 120 mg ORAL ANDA 12 sections
ISOSORBIDE MONONITRATE HUMAN PRESCRIPTION DRUG LABEL 1 10544-243 TABLET, EXTENDED RELEASE 60 mg ORAL ANDA 21 sections
ISOSORBIDE MONONITRATE HUMAN PRESCRIPTION DRUG LABEL 1 13668-104 TABLET, EXTENDED RELEASE 30 mg ORAL ANDA 12 sections
ISOSORBIDE MONONITRATE HUMAN PRESCRIPTION DRUG LABEL 1 13668-104 TABLET, EXTENDED RELEASE 30 mg ORAL ANDA 12 sections
ISOSORBIDE MONONITRATE HUMAN PRESCRIPTION DRUG LABEL 1 13668-104 TABLET, EXTENDED RELEASE 30 mg ORAL ANDA 12 sections
ISOSORBIDE MONONITRATE HUMAN PRESCRIPTION DRUG LABEL 1 13668-105 TABLET, EXTENDED RELEASE 60 mg ORAL ANDA 12 sections
ISOSORBIDE MONONITRATE HUMAN PRESCRIPTION DRUG LABEL 1 13668-105 TABLET, EXTENDED RELEASE 60 mg ORAL ANDA 12 sections
ISOSORBIDE MONONITRATE HUMAN PRESCRIPTION DRUG LABEL 1 13668-105 TABLET, EXTENDED RELEASE 60 mg ORAL ANDA 12 sections
ISOSORBIDE MONONITRATE HUMAN PRESCRIPTION DRUG LABEL 1 13668-106 TABLET, EXTENDED RELEASE 120 mg ORAL ANDA 12 sections
ISOSORBIDE MONONITRATE HUMAN PRESCRIPTION DRUG LABEL 1 13668-106 TABLET, EXTENDED RELEASE 120 mg ORAL ANDA 12 sections
ISOSORBIDE MONONITRATE HUMAN PRESCRIPTION DRUG LABEL 1 13668-106 TABLET, EXTENDED RELEASE 120 mg ORAL ANDA 12 sections
isosorbide mononitrate HUMAN PRESCRIPTION DRUG LABEL 1 16729-396 TABLET, EXTENDED RELEASE 30 mg ORAL ANDA 23 sections
isosorbide mononitrate HUMAN PRESCRIPTION DRUG LABEL 1 16729-397 TABLET, EXTENDED RELEASE 60 mg ORAL ANDA 23 sections
isosorbide mononitrate HUMAN PRESCRIPTION DRUG LABEL 1 16729-398 TABLET, EXTENDED RELEASE 120 mg ORAL ANDA 23 sections
isosorbide mononitrate HUMAN PRESCRIPTION DRUG LABEL 1 21695-575 TABLET, EXTENDED RELEASE 30 mg ORAL ANDA 23 sections
isosorbide mononitrate HUMAN PRESCRIPTION DRUG LABEL 1 21695-777 TABLET, EXTENDED RELEASE 120 mg ORAL ANDA 23 sections