isosorbide mononitrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
NO2 - derivatives	1506	16051-77-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: isosorbide mononitrate isosorbide 5-mononitrate isosorbide 5-nitrate monosorbitrate isosorbide-5-mononitrate	for prevention of angina pectoris; structure given in first source; a Russian drug Molecular weight: 191.14 Formula: C6H9NO6 CLOGP: -0.81 LIPINSKI: 0 HAC: 7 HDO: 1 TPSA: 93.74 ALOGS: -0.53 ROTB: 2 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

isosorbide mononitrate
isosorbide 5-mononitrate
isosorbide 5-nitrate
monosorbitrate
isosorbide-5-mononitrate

for prevention of angina pectoris; structure given in first source; a Russian drug

Molecular weight: 191.14
Formula: C6H9NO6
CLOGP: -0.81
LIPINSKI: 0
HAC: 7
HDO: 1
TPSA: 93.74
ALOGS: -0.53
ROTB: 2

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
40	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	1.10 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	2.50 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	8.97 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	93 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	0.70 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	2 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	1 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	4.10 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Dec. 30, 1991	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Myocardial infarction	394.05	13.34	335	27299	99558	63361830
Cardiac failure congestive	271.91	13.34	263	27371	92170	63369218
Acute myocardial infarction	180.83	13.34	133	27501	31991	63429397
Subarachnoid haemorrhage	173.12	13.34	96	27538	14187	63447201
Cardiospasm	172.35	13.34	54	27580	1853	63459535
Palmoplantar keratoderma	169.63	13.34	54	27580	1953	63459435
Pruritus genital	158.68	13.34	55	27579	2599	63458789
Sleep terror	154.31	13.34	54	27580	2626	63458762
Chest pain	153.57	13.34	309	27325	215650	63245738
Coronary artery disease	149.18	13.34	119	27515	32258	63429130
Angina pectoris	141.68	13.34	112	27522	29966	63431422
Atrial tachycardia	140.43	13.34	57	27577	4183	63457205
Carotid artery occlusion	131.51	13.34	56	27578	4638	63456750
Tension headache	129.36	13.34	57	27577	5129	63456259
Drug ineffective	118.96	13.34	170	27464	1044595	62416793
Immunisation	108.72	13.34	34	27600	1159	63460229
Anosmia	108.27	13.34	55	27579	6805	63454583
Ventricular tachycardia	106.32	13.34	80	27554	19899	63441489
Hypoglycaemia	104.85	13.34	130	27504	59935	63401453
Acute kidney injury	87.87	13.34	283	27351	263132	63198256
Lip swelling	86.73	13.34	86	27548	30977	63430411
Hyponatraemia	86.50	13.34	166	27468	111734	63349654
Pain of skin	83.69	13.34	56	27578	11578	63449810
Facial pain	83.68	13.34	54	27580	10507	63450881
Contraindicated product administered	78.22	13.34	4	27630	217644	63243744
Vasculitis	77.67	13.34	64	27570	18145	63443243
Drug intolerance	74.61	13.34	21	27613	308640	63152748
Angina unstable	70.74	13.34	42	27592	7053	63454335
Parkinsonism	69.74	13.34	48	27586	10391	63450997
Systemic lupus erythematosus	68.75	13.34	6	27628	208912	63252476
Cardiac failure	68.58	13.34	132	27502	89010	63372378
Dementia	67.79	13.34	60	27574	18734	63442654
Drug interaction	67.35	13.34	236	27398	228895	63232493
Blindness	66.05	13.34	63	27571	21636	63439752
Angioedema	65.42	13.34	92	27542	47873	63413515
Melaena	65.04	13.34	73	27561	30292	63431096
Arthropathy	64.64	13.34	12	27622	234780	63226608
Eye pruritus	64.16	13.34	58	27576	18613	63442775
Rheumatoid arthritis	63.72	13.34	16	27618	253803	63207585
Diplopia	63.12	13.34	64	27570	23664	63437724
Infusion related reaction	62.57	13.34	15	27619	245506	63215882
Coronary arterial stent insertion	60.72	13.34	28	27606	2801	63458587
Cardiorenal syndrome	59.61	13.34	20	27614	855	63460533
Bradycardia	58.24	13.34	110	27524	73117	63388271
Muscle twitching	57.78	13.34	56	27578	19612	63441776
Tinnitus	57.21	13.34	74	27560	35554	63425834
Maternal exposure during pregnancy	56.95	13.34	13	27621	220049	63241339
Transient ischaemic attack	55.36	13.34	75	27559	37678	63423710
Atrial fibrillation	54.98	13.34	142	27492	116494	63344894
Cognitive disorder	54.88	13.34	92	27542	55723	63405665
Hyperkalaemia	54.17	13.34	90	27544	54113	63407275
Intentional product misuse	54.12	13.34	96	27538	60821	63400567
Glossodynia	54.09	13.34	7	27627	178869	63282519
Hallucination	52.10	13.34	89	27545	54728	63406660
Hypotension	51.58	13.34	245	27389	272359	63189029
Multiple drug therapy	51.12	13.34	27	27607	3619	63457769
Wound	50.31	13.34	6	27628	163257	63298131
Peripheral circulatory failure	50.01	13.34	18	27616	950	63460438
Mucosal erosion	48.90	13.34	20	27614	1496	63459892
Blood glucose increased	48.04	13.34	110	27524	83646	63377742
Fear of eating	47.88	13.34	14	27620	378	63461010
Dizziness	47.02	13.34	334	27300	429591	63031797
Therapeutic product effect decreased	46.91	13.34	13	27621	193174	63268214
Syncope	46.42	13.34	134	27500	117251	63344137
Toxic epidermal necrolysis	46.07	13.34	56	27578	25278	63436110
Joint swelling	44.74	13.34	46	27588	327620	63133768
Disturbance in attention	43.06	13.34	67	27567	38122	63423266
Swelling	40.69	13.34	36	27598	275342	63186046
Fall	40.12	13.34	300	27334	392034	63069354
Stomatitis	38.35	13.34	7	27627	138718	63322670
Nasopharyngitis	37.85	13.34	33	27601	254224	63207164
Hepatic enzyme increased	37.04	13.34	21	27613	202307	63259081
Renal impairment	37.01	13.34	103	27531	88252	63373136
Sinusitis	36.76	13.34	27	27607	226626	63234762
Chronic obstructive pulmonary disease	36.68	13.34	83	27551	62603	63398785
Myocardial ischaemia	36.62	13.34	36	27598	12823	63448565
Dermatitis exfoliative	36.22	13.34	25	27609	5434	63455954
Sodium retention	35.89	13.34	9	27625	133	63461255
Intestinal ischaemia	35.56	13.34	28	27606	7440	63453948
Anxiety disorder	35.30	13.34	22	27612	4028	63457360
Iron deficiency anaemia	34.46	13.34	43	27591	19926	63441462
Atrioventricular block first degree	34.05	13.34	27	27607	7246	63454142
Rash papular	34.05	13.34	38	27596	15664	63445724
Musculoskeletal stiffness	34.03	13.34	19	27615	184599	63276789
Anti-neutrophil cytoplasmic antibody positive vasculitis	33.79	13.34	19	27615	2880	63458508
Product use issue	33.57	13.34	28	27606	220492	63240896
Cerebrovascular accident	33.18	13.34	113	27521	107911	63353477
Amnesia	32.97	13.34	74	27560	55511	63405877
Neuroglycopenia	32.86	13.34	11	27623	467	63460921
Gastrointestinal haemorrhage	32.40	13.34	93	27541	81083	63380305
Blood cholesterol decreased	32.32	13.34	13	27621	931	63460457
Blood urea increased	32.17	13.34	48	27586	26331	63435057
Dry skin	31.82	13.34	74	27560	56813	63404575
Medication error	31.45	13.34	70	27564	52214	63409174
Rhabdomyolysis	31.25	13.34	63	27571	43888	63417500
Discomfort	31.17	13.34	17	27617	167357	63294031
Memory impairment	31.10	13.34	108	27526	104150	63357238
Exposure during pregnancy	30.15	13.34	15	27619	155532	63305856
Dehydration	29.32	13.34	151	27483	173203	63288185
Hyperthyroidism	29.25	13.34	34	27600	14639	63446749
Hypersensitivity	28.90	13.34	52	27582	292633	63168755
Impaired healing	28.72	13.34	5	27629	102537	63358851
Cholecystitis	27.97	13.34	34	27600	15343	63446045
Chronic kidney disease	27.55	13.34	61	27573	45337	63416051
Therapeutic product effect incomplete	27.52	13.34	10	27624	125046	63336342
Palpitations	27.11	13.34	109	27525	112661	63348727
International normalised ratio increased	26.63	13.34	61	27573	46364	63415024
Gastric polyps	25.96	13.34	17	27617	3388	63458000
Neutropenia	25.68	13.34	23	27611	174982	63286406
Intentional overdose	24.94	13.34	80	27554	74072	63387316
Product administration error	24.84	13.34	39	27595	22358	63439030
Stupor	24.72	13.34	18	27616	4257	63457131
Blood creatine increased	24.54	13.34	20	27614	5581	63455807
Dialysis	23.93	13.34	26	27608	10401	63450987
Hypomagnesaemia	23.87	13.34	44	27590	28693	63432695
Peptic ulcer	23.58	13.34	18	27616	4569	63456819
Pain	23.47	13.34	208	27426	740420	62720968
Vasodilatation	23.41	13.34	14	27620	2381	63459007
Blood potassium increased	23.31	13.34	34	27600	18275	63443113
Blood creatinine increased	21.18	13.34	85	27549	87759	63373629
Upper gastrointestinal haemorrhage	21.14	13.34	33	27601	18819	63442569
Dyspnoea	21.05	13.34	404	27230	660909	62800479
Ill-defined disorder	20.79	13.34	5	27629	81750	63379638
Febrile neutropenia	20.67	13.34	13	27621	118436	63342952
Mitral valve stenosis	20.23	13.34	10	27624	1167	63460221
Blood cholesterol increased	19.89	13.34	8	27626	94024	63367364
Urinary retention	19.85	13.34	42	27592	30259	63431129
Visual impairment	19.79	13.34	81	27553	84365	63377023
Electrocardiogram QRS complex prolonged	19.52	13.34	18	27616	5920	63455468
Gastroenteritis bacterial	19.38	13.34	7	27627	373	63461015
Hyperparathyroidism	19.21	13.34	13	27621	2736	63458652
Nodal rhythm	19.18	13.34	11	27623	1732	63459656
Product residue present	19.12	13.34	15	27619	3964	63457424
Cardiac failure acute	18.87	13.34	22	27612	9501	63451887
Muscle injury	18.71	13.34	3	27631	65342	63396046
Drug dependence	18.49	13.34	36	27598	24447	63436941
Conjunctival discolouration	18.29	13.34	5	27629	105	63461283
Sinus arrest	18.04	13.34	11	27623	1938	63459450
Vitamin D deficiency	17.98	13.34	26	27608	13866	63447522
Labelled drug-drug interaction issue	17.88	13.34	9	27625	1092	63460296
Hiatus hernia	17.85	13.34	33	27601	21561	63439827
Acid base balance abnormal	17.74	13.34	6	27628	263	63461125
Micturition disorder	17.73	13.34	12	27622	2526	63458862
Corneal abrasion	17.70	13.34	9	27625	1115	63460273
Diabetes mellitus inadequate control	17.70	13.34	27	27607	15099	63446289
Psoriatic arthropathy	17.46	13.34	9	27625	91511	63369877
Infection	17.43	13.34	47	27587	229126	63232262
Cardiac disorder	17.24	13.34	55	27579	50761	63410627
Shock	17.12	13.34	34	27600	23429	63437959
Initial insomnia	17.09	13.34	17	27617	6140	63455248
Glomerular filtration rate abnormal	17.06	13.34	8	27626	831	63460557
Eosinophilic granulomatosis with polyangiitis	16.85	13.34	11	27623	2181	63459207
Fibromyalgia	16.75	13.34	7	27627	80413	63380975
Osteoporosis	16.74	13.34	59	27575	57279	63404109
Blood pressure decreased	16.55	13.34	64	27570	64958	63396430
Blood loss anaemia	16.53	13.34	20	27614	8981	63452407
Gastrointestinal tract mucosal pigmentation	16.26	13.34	7	27627	595	63460793
Tuberculosis of central nervous system	16.23	13.34	6	27628	342	63461046
Acute coronary syndrome	16.20	13.34	21	27613	10105	63451283
Arthritis	16.10	13.34	16	27618	115905	63345483
Coronary artery bypass	16.07	13.34	11	27623	2358	63459030
Metastatic neoplasm	16.06	13.34	14	27620	4281	63457107
Haemorrhoids	16.04	13.34	32	27602	22118	63439270
Tachycardia	16.02	13.34	97	27537	118059	63343329
Colitis microscopic	15.94	13.34	20	27614	9319	63452069
Irritable bowel syndrome	15.88	13.34	8	27626	82404	63378984
Off label use	15.83	13.34	203	27431	674259	62787129
Abdominal pain upper	15.77	13.34	148	27486	206296	63255092
Glomerulonephritis rapidly progressive	15.76	13.34	8	27626	987	63460401
Cardiac failure chronic	15.72	13.34	14	27620	4404	63456984
Bradykinesia	15.66	13.34	15	27619	5173	63456215
Lupus myocarditis	15.66	13.34	4	27630	64	63461324
Pulmonary oedema	15.62	13.34	56	27578	54817	63406571
Drug hypersensitivity	15.50	13.34	76	27558	310611	63150777
Dermatitis atopic	15.30	13.34	20	27614	9704	63451684
Completed suicide	15.17	13.34	25	27609	145648	63315740
Post procedural haemorrhage	15.12	13.34	18	27616	7946	63453442
Mitral valve incompetence	15.03	13.34	29	27605	19565	63441823
Renal failure	14.95	13.34	95	27539	117557	63343831
Schizophrenia	14.93	13.34	20	27614	9932	63451456
Procedural haemorrhage	14.82	13.34	11	27623	2677	63458711
Cutaneous lupus erythematosus	14.73	13.34	11	27623	2701	63458687
Anal haemorrhage	14.69	13.34	10	27624	2126	63459262
Electrolyte imbalance	14.53	13.34	29	27605	20047	63441341
Muscular weakness	14.45	13.34	97	27537	122256	63339132
Knee arthroplasty	14.41	13.34	3	27631	54203	63407185
Arteriosclerosis coronary artery	14.40	13.34	18	27616	8355	63453033
Hyperhidrosis	14.28	13.34	88	27546	107748	63353640
Gastrointestinal tract mucosal discolouration	14.12	13.34	3	27631	20	63461368
Electrocardiogram QT prolonged	13.87	13.34	57	27577	59473	63401915
Feeling abnormal	13.73	13.34	111	27523	148281	63313107
Motor dysfunction	13.72	13.34	20	27614	10741	63450647
Urticaria	13.37	13.34	33	27601	165769	63295619
Lethargy	13.34	13.34	54	27580	55953	63405435

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Myocardial infarction	320.66	12.82	460	30364	120625	34805482
Cardiac failure congestive	283.91	12.82	358	30466	82912	34843195
Cardiospasm	189.77	12.82	66	30758	1522	34924585
Angina pectoris	181.46	12.82	178	30646	31185	34894922
Palmoplantar keratoderma	172.79	12.82	65	30759	1888	34924219
Acute myocardial infarction	170.35	12.82	223	30601	53496	34872611
Pruritus genital	161.65	12.82	64	30760	2140	34923967
Sleep terror	158.52	12.82	64	30760	2254	34923853
Chest pain	156.50	12.82	345	30479	126417	34799690
Tension headache	154.58	12.82	68	30756	2974	34923133
Atrial tachycardia	139.77	12.82	67	30757	3578	34922529
Carotid artery occlusion	138.18	12.82	67	30757	3670	34922437
Coronary artery disease	137.06	12.82	190	30634	48115	34877992
Facial pain	132.73	12.82	65	30759	3639	34922468
Anosmia	130.54	12.82	66	30758	3958	34922149
Immunisation	129.61	12.82	45	30779	1032	34925075
Pain of skin	112.41	12.82	69	30755	6040	34920067
Drug ineffective	108.66	12.82	147	30677	456604	34469503
Angina unstable	96.60	12.82	81	30743	11572	34914535
Eye pruritus	94.91	12.82	67	30757	7422	34918685
Ventricular tachycardia	94.70	12.82	117	30707	26462	34899645
Muscle twitching	90.40	12.82	74	30750	10224	34915883
Lip swelling	88.75	12.82	89	30735	15991	34910116
Subarachnoid haemorrhage	86.96	12.82	79	30745	12556	34913551
Vasculitis	82.43	12.82	73	30751	11223	34914884
Hypotension	81.17	12.82	398	30426	221251	34704856
Pericarditis	78.56	12.82	72	30752	11573	34914534
Dizziness	76.18	12.82	387	30437	218134	34707973
Cardiac failure	70.28	12.82	208	30616	91040	34835067
Hallucination	65.46	12.82	142	30682	51356	34874751
Blindness	61.65	12.82	71	30753	14915	34911192
Transient ischaemic attack	60.13	12.82	96	30728	27517	34898590
Cognitive disorder	60.09	12.82	98	30726	28595	34897512
Off label use	59.41	12.82	182	30642	419342	34506765
Rash papular	58.77	12.82	58	30766	10220	34915887
Syncope	56.28	12.82	193	30631	91258	34834849
Presyncope	55.55	12.82	76	30748	18983	34907124
Diplopia	54.99	12.82	71	30753	16772	34909335
Drug abuse	53.68	12.82	11	30813	99085	34827022
Migraine	52.92	12.82	71	30753	17407	34908700
Dry skin	48.90	12.82	94	30730	31193	34894914
Amnesia	48.05	12.82	85	30739	26478	34899629
Myocardial ischaemia	47.12	12.82	67	30757	17341	34908766
Coronary arterial stent insertion	45.62	12.82	34	30790	4095	34922012
Palpitations	44.92	12.82	105	30719	39881	34886226
Dyspnoea	43.52	12.82	515	30309	376267	34549840
Disturbance in attention	43.08	12.82	80	30744	25865	34900242
Blood glucose increased	42.96	12.82	143	30681	66575	34859532
Anti-neutrophil cytoplasmic antibody positive vasculitis	41.56	12.82	19	30805	910	34925197
Tinnitus	41.15	12.82	68	30756	20050	34906057
Alopecia	39.07	12.82	74	30750	24281	34901826
Product use in unapproved indication	39.07	12.82	28	30796	117471	34808636
Visual impairment	38.03	12.82	92	30732	35710	34890397
Venous pressure jugular increased	37.79	12.82	17	30807	784	34925323
Blood potassium increased	36.80	12.82	58	30766	16437	34909670
Febrile neutropenia	36.61	12.82	40	30784	136809	34789298
Angioedema	36.50	12.82	93	30731	37281	34888826
Bradycardia	36.21	12.82	147	30677	75271	34850836
International normalised ratio increased	35.55	12.82	107	30717	47220	34878887
Left atrial dilatation	32.83	12.82	21	30803	1975	34924132
Gastrointestinal haemorrhage	32.33	12.82	159	30665	88318	34837789
Atrial fibrillation	30.82	12.82	199	30625	122194	34803913
Completed suicide	30.57	12.82	25	30799	98143	34827964
Ventricular dysfunction	30.02	12.82	26	30798	3879	34922228
Memory impairment	29.81	12.82	95	30729	43223	34882884
Haematocrit increased	29.34	12.82	20	30804	2093	34924014
Malignant neoplasm progression	29.23	12.82	21	30803	88025	34838082
Chest discomfort	29.18	12.82	110	30714	54420	34871687
Venous pressure jugular decreased	28.95	12.82	7	30817	40	34926067
Drug interaction	28.75	12.82	315	30509	225631	34700476
Upper gastrointestinal haemorrhage	28.64	12.82	67	30757	25451	34900656
Acute kidney injury	28.42	12.82	401	30423	304587	34621520
Mucosal dryness	26.98	12.82	16	30808	1315	34924792
Lupus pneumonitis	26.69	12.82	7	30817	58	34926049
Peripheral swelling	25.47	12.82	134	30690	76407	34849700
Arteriospasm coronary	24.95	12.82	22	30802	3360	34922747
Hyperhidrosis	24.83	12.82	132	30692	75560	34850547
Dehydration	24.43	12.82	197	30627	129772	34796335
Muscular weakness	23.83	12.82	127	30697	72770	34853337
Neutropenia	23.53	12.82	66	30758	156712	34769395
Wrong patient received product	23.13	12.82	19	30805	2635	34923472
Rhabdomyolysis	23.13	12.82	120	30704	68043	34858064
Malaise	23.13	12.82	258	30566	185567	34740540
Heart rate increased	21.96	12.82	90	30734	46253	34879854
Glomerular filtration rate decreased	21.55	12.82	40	30784	12921	34913186
Mucosal inflammation	21.50	12.82	4	30820	38618	34887489
Haemoglobin increased	20.91	12.82	20	30804	3389	34922718
Cardiac failure chronic	20.84	12.82	30	30794	7849	34918258
Toxicity to various agents	20.43	12.82	99	30725	200263	34725844
Pulmonary oedema	19.97	12.82	89	30735	47440	34878667
Hypovolaemia	19.95	12.82	32	30792	9202	34916905
Feeling abnormal	19.20	12.82	108	30716	63127	34862980
Rheumatoid arthritis	19.19	12.82	5	30819	38233	34887874
Hirsutism	19.12	12.82	7	30817	188	34925919
Nodal arrhythmia	18.97	12.82	11	30813	867	34925240
Orthostatic hypotension	18.89	12.82	58	30766	25861	34900246
Gravitational oedema	18.74	12.82	10	30814	670	34925437
Excessive cerumen production	18.62	12.82	8	30816	330	34925777
Coronary artery bypass	18.13	12.82	22	30802	4880	34921227
Oedema peripheral	18.04	12.82	173	30651	119639	34806468
Blood pressure systolic decreased	17.95	12.82	21	30803	4482	34921625
Abdominal pain upper	17.83	12.82	116	30708	71374	34854733
Nasal crusting	17.70	12.82	8	30816	373	34925734
Mast cell activation syndrome	17.43	12.82	7	30817	243	34925864
Drug reaction with eosinophilia and systemic symptoms	17.18	12.82	4	30820	33008	34893099
Pterygium	17.18	12.82	6	30818	140	34925967
General physical health deterioration	17.10	12.82	57	30767	128212	34797895
Cardiac failure acute	16.80	12.82	32	30792	10538	34915569
Ischaemic cardiomyopathy	16.42	12.82	24	30800	6365	34919742
Nitritoid reaction	16.38	12.82	4	30820	24	34926083
Stent placement	15.94	12.82	21	30803	5057	34921050
Infusion related reaction	15.91	12.82	14	30810	53043	34873064
Pancytopenia	15.84	12.82	38	30786	95119	34830988
Pyrexia	15.84	12.82	203	30621	332810	34593297
Arrhythmia	15.76	12.82	68	30756	35740	34890367
Therapeutic product effect incomplete	15.57	12.82	13	30811	50528	34875579
Electrocardiogram ST segment elevation	15.43	12.82	21	30803	5217	34920890
Septic arthritis staphylococcal	15.39	12.82	8	30816	508	34925599
Arteriosclerosis coronary artery	15.36	12.82	34	30790	12451	34913656
Seizure	15.09	12.82	45	30779	104812	34821295
Linear IgA disease	14.93	12.82	12	30812	1614	34924493
Infection	14.59	12.82	37	30787	90878	34835229
Acute coronary syndrome	14.58	12.82	35	30789	13510	34912597
Tachycardia	14.58	12.82	126	30698	84646	34841461
Rash	14.56	12.82	126	30698	222626	34703481
Contusion	14.46	12.82	67	30757	36297	34889810
Condition aggravated	14.27	12.82	105	30719	192091	34734016
Prostate cancer	13.76	12.82	9	30815	39640	34886467
Encephalopathy	13.70	12.82	7	30817	35312	34890795
Abdominal discomfort	13.66	12.82	95	30729	59740	34866367
Neutrophil count decreased	13.58	12.82	15	30809	51089	34875018
Eczema nummular	13.56	12.82	5	30819	137	34925970
Faeces discoloured	13.47	12.82	36	30788	14842	34911265
Injection site pain	13.34	12.82	9	30815	38996	34887111
Bundle branch block left	13.30	12.82	21	30803	5958	34920149
Drug intolerance	13.23	12.82	20	30804	59550	34866557
Treatment failure	13.20	12.82	13	30811	46684	34879423
Incarcerated hernia	12.92	12.82	5	30819	157	34925950

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Myocardial infarction	708.51	12.06	732	51814	183397	79508445
Cardiac failure congestive	525.57	12.06	554	51992	141848	79549994
Cardiospasm	343.60	12.06	115	52431	3186	79688656
Acute myocardial infarction	343.01	12.06	332	52214	76704	79615138
Palmoplantar keratoderma	326.41	12.06	114	52432	3602	79688240
Pruritus genital	305.44	12.06	114	52432	4372	79687470
Sleep terror	302.48	12.06	113	52433	4345	79687497
Angina pectoris	270.76	12.06	244	52302	51488	79640354
Atrial tachycardia	270.38	12.06	119	52427	7014	79684828
Tension headache	269.13	12.06	119	52427	7092	79684750
Coronary artery disease	263.29	12.06	267	52279	65207	79626635
Carotid artery occlusion	259.27	12.06	118	52428	7529	79684313
Chest pain	253.46	12.06	568	51978	281736	79410106
Subarachnoid haemorrhage	239.77	12.06	167	52379	24298	79667544
Anosmia	236.90	12.06	116	52430	8728	79683114
Immunisation	223.58	12.06	75	52471	2092	79689750
Facial pain	200.47	12.06	116	52430	12234	79679608
Drug ineffective	196.30	12.06	256	52290	1080657	78611185
Pain of skin	192.47	12.06	120	52426	14493	79677349
Ventricular tachycardia	190.82	12.06	183	52363	41752	79650090
Angina unstable	174.17	12.06	118	52428	16409	79675433
Lip swelling	166.54	12.06	168	52378	40743	79651099
Vasculitis	154.69	12.06	130	52416	24972	79666870
Eye pruritus	151.01	12.06	118	52428	20452	79671390
Muscle twitching	145.94	12.06	125	52421	24639	79667203
Blindness	127.48	12.06	123	52423	28260	79663582
Acute kidney injury	124.02	12.06	671	51875	518733	79173109
Diplopia	122.80	12.06	130	52416	33336	79658506
Hypotension	122.64	12.06	594	51952	439723	79252119
Hallucination	122.43	12.06	210	52336	85535	79606307
Cardiac failure	116.36	12.06	291	52255	154551	79537291
Coronary arterial stent insertion	114.97	12.06	63	52483	5981	79685861
Cognitive disorder	114.27	12.06	182	52364	69744	79622098
Transient ischaemic attack	111.75	12.06	155	52391	52540	79639302
Dizziness	107.22	12.06	652	51894	525789	79166053
Drug intolerance	100.74	12.06	25	52521	264094	79427748
Syncope	96.01	12.06	298	52248	179151	79512691
Rash papular	94.71	12.06	93	52453	21823	79670019
Angioedema	94.13	12.06	175	52371	75860	79615982
Rheumatoid arthritis	91.54	12.06	14	52532	208456	79483386
Bradycardia	90.75	12.06	244	52302	135313	79556529
Tinnitus	90.42	12.06	128	52418	44205	79647637
Disturbance in attention	89.64	12.06	137	52409	50664	79641178
Atrial fibrillation	86.57	12.06	307	52239	197579	79494263
Synovitis	85.91	12.06	3	52543	150731	79541111
Blood glucose increased	85.20	12.06	215	52331	114760	79577082
Dry skin	83.54	12.06	156	52390	67839	79624003
Drug interaction	83.01	12.06	512	52034	414671	79277171
Infusion related reaction	80	12.06	26	52520	230211	79461631
Sinusitis	75.51	12.06	18	52528	195483	79496359
Arthropathy	75.28	12.06	13	52533	177098	79514744
Gastrointestinal haemorrhage	73.22	12.06	239	52307	147480	79544362
Amnesia	72.93	12.06	141	52405	62916	79628926
Off label use	71.81	12.06	331	52215	906884	78784958
Treatment failure	71.40	12.06	13	52533	170473	79521369
Myocardial ischaemia	71.22	12.06	86	52460	25433	79666409
Hyperkalaemia	70.68	12.06	200	52346	114198	79577644
Contraindicated product administered	70.49	12.06	10	52536	157528	79534314
Anti-neutrophil cytoplasmic antibody positive vasculitis	68.54	12.06	38	52508	3691	79688151
Hypoglycaemia	68.10	12.06	183	52363	101411	79590431
Rhabdomyolysis	65.38	12.06	182	52364	102949	79588893
Palpitations	64.68	12.06	207	52339	126403	79565439
Hyponatraemia	63.78	12.06	259	52287	177589	79514253
Melaena	63.03	12.06	130	52416	60760	79631082
Therapeutic product effect decreased	61.51	12.06	16	52530	163847	79527995
Dehydration	58.58	12.06	320	52226	247867	79443975
Blood potassium increased	57.45	12.06	83	52463	29192	79662650
Memory impairment	56.45	12.06	182	52364	111552	79580290
Joint swelling	55.56	12.06	65	52481	288581	79403261
International normalised ratio increased	54.17	12.06	150	52396	84571	79607271
Stomatitis	53.81	12.06	15	52531	146742	79545100
Intentional product misuse	53.61	12.06	161	52385	95004	79596838
Febrile neutropenia	52.48	12.06	45	52501	230954	79460888
Maternal exposure during pregnancy	51.88	12.06	13	52533	136525	79555317
Presyncope	51.43	12.06	95	52451	40959	79650883
Fear of eating	51.30	12.06	17	52529	456	79691386
Systemic lupus erythematosus	51.23	12.06	9	52537	121140	79570702
Completed suicide	50.99	12.06	52	52494	245715	79446127
Drug abuse	50.43	12.06	22	52524	162669	79529173
Dyspnoea	49.69	12.06	816	51730	856209	78835633
Upper gastrointestinal haemorrhage	49.65	12.06	94	52452	41286	79650556
Wound	48.33	12.06	9	52537	116170	79575672
Visual impairment	48.29	12.06	152	52394	91979	79599863
Nasopharyngitis	45.88	12.06	60	52486	253821	79438021
Product use in unapproved indication	44.39	12.06	60	52486	250299	79441543
Mucosal erosion	43.64	12.06	24	52522	2294	79689548
Peripheral circulatory failure	43.04	12.06	19	52527	1127	79690715
Multiple drug therapy	42.68	12.06	29	52517	4049	79687793
Therapeutic product effect incomplete	42.58	12.06	20	52526	141625	79550217
Neutropenia	42.43	12.06	78	52468	287632	79404210
Musculoskeletal stiffness	42.36	12.06	32	52514	174976	79516866
Swelling	40.41	12.06	50	52496	216661	79475181
Cardiac failure chronic	40.38	12.06	43	52503	11092	79680750
Hyperhidrosis	40.31	12.06	202	52344	151290	79540552
Product use issue	39.56	12.06	48	52498	209774	79482068
Pemphigus	38.77	12.06	9	52537	99573	79592269
Dementia	38.64	12.06	63	52483	24596	79667246
Coronary artery bypass	38.59	12.06	32	52514	6030	79685812
Infection	37.93	12.06	63	52483	241649	79450193
Muscular weakness	37.73	12.06	207	52339	160522	79531320
Cardiorenal syndrome	37.12	12.06	19	52527	1570	79690272
Ventricular dysfunction	36.70	12.06	31	52515	5992	79685850
Glossodynia	35.29	12.06	12	52534	103325	79588517
Cardiac failure acute	34.73	12.06	52	52494	18877	79672965
Pulmonary oedema	34.41	12.06	132	52414	88122	79603720
Left atrial dilatation	34.38	12.06	23	52523	3130	79688712
Venous pressure jugular increased	34.17	12.06	17	52529	1323	79690519
Impaired healing	33.97	12.06	8	52538	87647	79604195
Renal impairment	33.60	12.06	198	52348	157585	79534257
Mucosal inflammation	33.33	12.06	5	52541	75575	79616267
Hypersensitivity	32.84	12.06	78	52468	262161	79429681
Exposure during pregnancy	32.42	12.06	13	52533	101119	79590723
Helicobacter infection	32.18	12.06	4	52542	69700	79622142
Feeling abnormal	31.50	12.06	196	52350	159003	79532839
Atrioventricular block first degree	31.48	12.06	40	52506	12451	79679391
Dermatitis exfoliative	31.04	12.06	37	52509	10792	79681050
Arthritis	30.47	12.06	19	52527	114861	79576981
Psoriatic arthropathy	30.46	12.06	7	52539	77992	79613850
Discomfort	30.35	12.06	23	52523	125594	79566248
Glomerular filtration rate decreased	30.29	12.06	54	52492	22648	79669194
Ischaemic cardiomyopathy	30.20	12.06	31	52515	7664	79684178
Arteriosclerosis coronary artery	29.95	12.06	47	52499	17769	79674073
Blood creatine increased	29.93	12.06	34	52512	9421	79682421
Parkinsonism	29.63	12.06	45	52501	16539	79675303
Migraine	29.43	12.06	125	52421	87368	79604474
Sodium retention	29.28	12.06	9	52537	188	79691654
Malignant neoplasm progression	29.07	12.06	28	52518	135962	79555880
Fibromyalgia	28.97	12.06	4	52542	64336	79627506
Cerebrovascular accident	28.75	12.06	188	52358	155104	79536738
Tachycardia	28.65	12.06	208	52338	177560	79514282
Injection site pain	28.62	12.06	26	52520	129812	79562030
Gastric polyps	28.59	12.06	22	52524	3725	79688117
General physical health deterioration	28.38	12.06	90	52456	275148	79416694
Neuroglycopenia	28.27	12.06	11	52535	473	79691369
Hepatic enzyme increased	27.35	12.06	49	52497	182561	79509281
Drug reaction with eosinophilia and systemic symptoms	26.67	12.06	5	52541	64239	79627603
Lupus pneumonitis	26.53	12.06	7	52539	82	79691760
Gravitational oedema	26.50	12.06	16	52530	1823	79690019
Venous pressure jugular decreased	26.38	12.06	7	52539	84	79691758
Arteriospasm coronary	26.26	12.06	27	52519	6689	79685153
Blood urea increased	26.02	12.06	81	52465	48709	79643133
Irritable bowel syndrome	25.50	12.06	5	52541	62236	79629606
Blood pressure decreased	25.30	12.06	131	52415	99335	79592507
Chronic obstructive pulmonary disease	24.93	12.06	117	52429	85302	79606540
Haemoglobin increased	24.61	12.06	25	52521	6107	79685735
Acute coronary syndrome	24.11	12.06	47	52499	21086	79670756
Osteoarthritis	23.76	12.06	14	52532	87295	79604547
Rash	23.39	12.06	256	52290	578102	79113740
Urticaria	23.24	12.06	55	52491	185146	79506696
Bundle branch block left	23.11	12.06	33	52513	11480	79680362
Heart rate increased	22.86	12.06	147	52399	120577	79571265
Malaise	22.79	12.06	451	52095	489418	79202424
Orthostatic hypotension	22.71	12.06	85	52461	56079	79635763
Wrong patient received product	22.61	12.06	21	52525	4597	79687245
Condition aggravated	22.23	12.06	217	52329	500907	79190935
Muscle injury	21.91	12.06	3	52543	48558	79643284
Rectal haemorrhage	21.90	12.06	104	52442	76196	79615646
Ill-defined disorder	21.89	12.06	8	52538	65867	79625975
Arrhythmia	21.75	12.06	89	52457	61183	79630659
Abdominal pain upper	21.57	12.06	234	52312	223585	79468257
Haematocrit increased	21.03	12.06	19	52527	4015	79687827
Blood loss anaemia	20.85	12.06	37	52509	15461	79676381
Atrioventricular block	20.83	12.06	35	52511	14006	79677836
Fall	20.40	12.06	442	52104	487187	79204655
Toxicity to various agents	20.21	12.06	179	52367	421361	79270481
Cholecystitis	20.19	12.06	45	52501	22167	79669675
Toxic epidermal necrolysis	20.17	12.06	70	52476	44511	79647331
Faeces discoloured	20.04	12.06	53	52493	29074	79662768
Oedema peripheral	19.98	12.06	254	52292	252034	79439808
Oxygen saturation decreased	19.89	12.06	34	52512	129013	79562829
Prinzmetal angina	19.85	12.06	13	52533	1707	79690135
Blood cholesterol decreased	19.82	12.06	13	52533	1712	79690130
Neutrophil count decreased	19.33	12.06	20	52526	93939	79597903
Pain	19.31	12.06	337	52209	703465	78988377
Injection site erythema	19.30	12.06	14	52532	78183	79613659
Chest discomfort	19.15	12.06	156	52390	137888	79553954
Mitral valve stenosis	18.67	12.06	11	52535	1199	79690643
Coronary artery occlusion	18.63	12.06	35	52511	15280	79676562
Weight increased	18.54	12.06	107	52439	277279	79414563
Sinus bradycardia	18.46	12.06	47	52499	25200	79666642
Blood creatinine increased	18.26	12.06	169	52377	154888	79536954
Electrocardiogram ST segment elevation	18.24	12.06	25	52521	8372	79683470
Hypomagnesaemia	18.14	12.06	70	52476	46841	79645001
Drug hypersensitivity	18.06	12.06	119	52427	298797	79393045
Glomerular filtration rate abnormal	17.92	12.06	12	52534	1636	79690206
Sleep disorder	17.89	12.06	18	52528	85659	79606183
Pruritus	17.89	12.06	362	52184	394286	79297556
Neoplasm progression	17.65	12.06	6	52540	51676	79640166
Excessive cerumen production	17.61	12.06	9	52537	741	79691101
Gastrointestinal tract mucosal pigmentation	17.40	12.06	10	52536	1040	79690802
Hypovolaemia	17.40	12.06	37	52509	17654	79674188
Ventricular hypertrophy	17.14	12.06	22	52524	6916	79684926
Inflammation	17.08	12.06	22	52524	93731	79598111
Mucosal dryness	17.07	12.06	16	52530	3543	79688299
Ventricular fibrillation	17.02	12.06	53	52493	31873	79659969
Intestinal ischaemia	16.98	12.06	31	52515	13239	79678603
Nitritoid reaction	16.88	12.06	4	52542	29	79691813
COVID-19	16.67	12.06	168	52378	157506	79534336
Knee arthroplasty	16.65	12.06	4	52542	43244	79648598
Vasodilatation	16.58	12.06	15	52531	3176	79688666
Disease progression	16.50	12.06	64	52482	184298	79507544
Therapeutic response decreased	16.46	12.06	12	52534	66841	79625001
Nasal crusting	16.34	12.06	8	52538	601	79691241
Injection site reaction	16.05	12.06	8	52538	54777	79637065
Shock	16.05	12.06	64	52482	43484	79648358
Upper respiratory tract infection	15.99	12.06	22	52524	91146	79600696
Corneal abrasion	15.87	12.06	10	52536	1229	79690613
Mitral valve incompetence	15.77	12.06	48	52498	28517	79663325
Pericarditis	15.67	12.06	120	52426	104116	79587726
Gastroenteritis bacterial	15.44	12.06	7	52539	442	79691400
Conjunctival discolouration	15.31	12.06	5	52541	128	79691714
White blood cell count decreased	15.21	12.06	68	52478	188220	79503622
Liver function test abnormal	15.09	12.06	83	52463	64392	79627450
Cardiac disorder	14.95	12.06	84	52462	65673	79626169
Renal failure	14.93	12.06	200	52346	200768	79491074
Hyperthyroidism	14.86	12.06	40	52506	22169	79669673
Weight decreased	14.82	12.06	156	52390	355042	79336800
Electrocardiogram QRS complex prolonged	14.75	12.06	26	52520	10807	79681035
Gastritis erosive	14.73	12.06	26	52520	10821	79681021
Arteriosclerosis	14.45	12.06	35	52511	18192	79673650
Blood pressure systolic decreased	14.33	12.06	26	52520	11050	79680792
Stupor	14.24	12.06	20	52526	6852	79684990
Septic arthritis staphylococcal	14.18	12.06	8	52538	803	79691039
Dialysis	14.16	12.06	35	52511	18427	79673415
Chronic kidney disease	14.06	12.06	83	52463	66071	79625771
Bronchitis	13.96	12.06	42	52504	130602	79561240
Hypercalcaemia	13.95	12.06	4	52542	38426	79653416
Lower gastrointestinal haemorrhage	13.91	12.06	32	52514	16093	79675749
Pyrexia	13.86	12.06	341	52205	678368	79013474
Nodal arrhythmia	13.77	12.06	11	52535	1967	79689875
Oliguria	13.67	12.06	32	52514	16277	79675565
Hiatus hernia	13.65	12.06	40	52506	23272	79668570
Sudden cardiac death	13.59	12.06	17	52529	5208	79686634
Stent placement	13.55	12.06	19	52527	6501	79685341
Acid base balance abnormal	13.43	12.06	6	52540	366	79691476
Subacute cutaneous lupus erythematosus	13.35	12.06	14	52532	3547	79688295
Multiple sclerosis relapse	13.33	12.06	7	52539	46526	79645316
Glomerulonephritis rapidly progressive	13.29	12.06	10	52536	1638	79690204
Atrioventricular block complete	13.28	12.06	32	52514	16578	79675264
Stress	13.18	12.06	20	52526	79592	79612250
Palmar-plantar erythrodysaesthesia syndrome	12.88	12.06	3	52543	33131	79658711
Vascular stent thrombosis	12.88	12.06	14	52532	3696	79688146
Peripheral arterial occlusive disease	12.80	12.06	21	52525	8237	79683605
Leukopenia	12.78	12.06	37	52509	116476	79575366
Peptic ulcer	12.73	12.06	18	52528	6205	79685637
Lupus myocarditis	12.69	12.06	4	52542	91	79691751
Hyperparathyroidism	12.68	12.06	13	52533	3211	79688631
Asthma	12.67	12.06	46	52500	135049	79556793
Pneumonectomy	12.57	12.06	4	52542	94	79691748
Hip arthroplasty	12.47	12.06	4	52542	35752	79656090
Loss of personal independence in daily activities	12.44	12.06	31	52515	102549	79589293
Peripheral swelling	12.43	12.06	248	52298	269369	79422473
Labelled drug-drug interaction issue	12.35	12.06	9	52537	1404	79690438
Colitis microscopic	12.35	12.06	24	52522	10744	79681098
Paraesthesia	12.33	12.06	67	52479	176256	79515586
Blood creatine phosphokinase increased	12.21	12.06	80	52466	66010	79625832
Injection site swelling	12.21	12.06	8	52538	47124	79644718

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	C01DA14	CARDIOVASCULAR SYSTEM CARDIAC THERAPY VASODILATORS USED IN CARDIAC DISEASES Organic nitrates
FDA CS	M0014874	Nitrates
FDA PE	N0000009909	Vasodilation
FDA EPC	N0000175415	Nitrate Vasodilator
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D020030	Nitric Oxide Donors
MeSH PA	D014665	Vasodilator Agents
CHEBI has role	CHEBI:35620	vasodilator agents
CHEBI has role	CHEBI:50566	nitric oxide generators

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Angina pectoris	indication	194828000
Angina Pectoris Prevention	indication
Chronic heart failure	off-label use	48447003
Prevention of Bleeding Esophageal Varices	off-label use
Myocardial infarction	contraindication	22298006	DOID:5844
Hyperthyroidism	contraindication	34486009	DOID:7998
Low blood pressure	contraindication	45007003
Injury of head	contraindication	82271004
Increased intestinal motility	contraindication	102624003
Hypertrophic cardiomyopathy	contraindication	233873004	DOID:11984
Anemia	contraindication	271737000	DOID:2355
Cerebral hemorrhage	contraindication	274100004
Malabsorption States	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Soluble guanylate cyclase	Enzyme	O75343 P33402 Q02108 Q02153	GCYB2_HUMAN GCYA2_HUMAN GCYA3_HUMAN GCYB1_HUMAN	ACTIVATOR				CHEMBL	CHEMBL
Atrial natriuretic peptide receptor 1	Enzyme	P16066	ANPRA_HUMAN					WOMBAT-PK

External reference:

ID	Source
4020224	VUID
N0000179163	NUI
D00630	KEGG_DRUG
4020224	VANDF
C0064079	UMLSCUI
CHEBI:6062	CHEBI
CHEMBL1311	ChEMBL_ID
DB01020	DRUGBANK_ID
27661	PUBCHEM_CID
5177	INN_ID
C030397	MESH_SUPPLEMENTAL_RECORD_UI
7052	IUPHAR_LIGAND_ID
LX1OH63030	UNII
28004	RXNORM
4935	MMSL
6257	MMSL
d00269	MMSL
003639	NDDF
108484003	SNOMEDCT_US
386854005	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Isosorbide Mononitrate	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2620	TABLET	20 mg	ORAL	ANDA	21 sections
Isosorbide Mononitrate	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2620	TABLET	20 mg	ORAL	ANDA	21 sections
Isosorbide Mononitrate	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2631	TABLET	10 mg	ORAL	ANDA	21 sections
Isosorbide Mononitrate	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2631	TABLET	10 mg	ORAL	ANDA	21 sections
ISOSORBIDE MONONITRATE	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7767	TABLET, EXTENDED RELEASE	30 mg	ORAL	ANDA	12 sections
ISOSORBIDE MONONITRATE	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7768	TABLET, EXTENDED RELEASE	60 mg	ORAL	ANDA	20 sections
ISOSORBIDE MONONITRATE	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8043	TABLET	30 mg	ORAL	ANDA	23 sections
ISOSORBIDE MONONITRATE	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8043	TABLET	30 mg	ORAL	ANDA	23 sections
ISOSORBIDE MONONITRATE	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8044	TABLET	60 mg	ORAL	ANDA	23 sections
ISOSORBIDE MONONITRATE	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8044	TABLET	60 mg	ORAL	ANDA	23 sections
ISOSORBIDE MONONITRATE	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6449	TABLET, EXTENDED RELEASE	30 mg	ORAL	ANDA	12 sections
ISOSORBIDE MONONITRATE	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6449	TABLET, EXTENDED RELEASE	30 mg	ORAL	ANDA	12 sections
ISOSORBIDE MONONITRATE	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6450	TABLET, EXTENDED RELEASE	60 mg	ORAL	ANDA	12 sections
ISOSORBIDE MONONITRATE	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6450	TABLET, EXTENDED RELEASE	60 mg	ORAL	ANDA	12 sections
ISOSORBIDE MONONITRATE	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6451	TABLET, EXTENDED RELEASE	120 mg	ORAL	ANDA	12 sections
ISOSORBIDE MONONITRATE	HUMAN PRESCRIPTION DRUG LABEL	1	10544-243	TABLET, EXTENDED RELEASE	60 mg	ORAL	ANDA	21 sections
ISOSORBIDE MONONITRATE	HUMAN PRESCRIPTION DRUG LABEL	1	13668-104	TABLET, EXTENDED RELEASE	30 mg	ORAL	ANDA	12 sections
ISOSORBIDE MONONITRATE	HUMAN PRESCRIPTION DRUG LABEL	1	13668-104	TABLET, EXTENDED RELEASE	30 mg	ORAL	ANDA	12 sections
ISOSORBIDE MONONITRATE	HUMAN PRESCRIPTION DRUG LABEL	1	13668-104	TABLET, EXTENDED RELEASE	30 mg	ORAL	ANDA	12 sections
ISOSORBIDE MONONITRATE	HUMAN PRESCRIPTION DRUG LABEL	1	13668-105	TABLET, EXTENDED RELEASE	60 mg	ORAL	ANDA	12 sections
ISOSORBIDE MONONITRATE	HUMAN PRESCRIPTION DRUG LABEL	1	13668-105	TABLET, EXTENDED RELEASE	60 mg	ORAL	ANDA	12 sections
ISOSORBIDE MONONITRATE	HUMAN PRESCRIPTION DRUG LABEL	1	13668-105	TABLET, EXTENDED RELEASE	60 mg	ORAL	ANDA	12 sections
ISOSORBIDE MONONITRATE	HUMAN PRESCRIPTION DRUG LABEL	1	13668-106	TABLET, EXTENDED RELEASE	120 mg	ORAL	ANDA	12 sections
ISOSORBIDE MONONITRATE	HUMAN PRESCRIPTION DRUG LABEL	1	13668-106	TABLET, EXTENDED RELEASE	120 mg	ORAL	ANDA	12 sections
ISOSORBIDE MONONITRATE	HUMAN PRESCRIPTION DRUG LABEL	1	13668-106	TABLET, EXTENDED RELEASE	120 mg	ORAL	ANDA	12 sections
isosorbide mononitrate	HUMAN PRESCRIPTION DRUG LABEL	1	16729-396	TABLET, EXTENDED RELEASE	30 mg	ORAL	ANDA	23 sections
isosorbide mononitrate	HUMAN PRESCRIPTION DRUG LABEL	1	16729-397	TABLET, EXTENDED RELEASE	60 mg	ORAL	ANDA	23 sections
isosorbide mononitrate	HUMAN PRESCRIPTION DRUG LABEL	1	16729-398	TABLET, EXTENDED RELEASE	120 mg	ORAL	ANDA	23 sections
isosorbide mononitrate	HUMAN PRESCRIPTION DRUG LABEL	1	21695-575	TABLET, EXTENDED RELEASE	30 mg	ORAL	ANDA	23 sections
isosorbide mononitrate	HUMAN PRESCRIPTION DRUG LABEL	1	21695-777	TABLET, EXTENDED RELEASE	120 mg	ORAL	ANDA	23 sections