isosorbide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	1501	652-67-5

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: isosorbide (+)-D-Isosorbide isobide	1,4:3,6-Dianhydro D-glucitol. Chemically inert osmotic diuretic used mainly to treat hydrocephalus; also used in glaucoma. Molecular weight: 146.14 Formula: C6H10O4 CLOGP: -1.53 LIPINSKI: 0 HAC: 4 HDO: 2 TPSA: 58.92 ALOGS: 0.92 ROTB: 0 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

isosorbide
(+)-D-Isosorbide
isobide

1,4:3,6-Dianhydro D-glucitol. Chemically inert osmotic diuretic used mainly to treat hydrocephalus; also used in glaucoma.

Molecular weight: 146.14
Formula: C6H10O4
CLOGP: -1.53
LIPINSKI: 0
HAC: 4
HDO: 2
TPSA: 58.92
ALOGS: 0.92
ROTB: 0

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Jan. 30, 1974	FDA	ALCON

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Myocardial infarction	197.77	13.87	183	16668	99710	63372461
Subarachnoid haemorrhage	195.89	13.87	89	16762	14194	63457977
Cardiospasm	194.10	13.87	53	16798	1854	63470317
Palmoplantar keratoderma	191.42	13.87	53	16798	1954	63470217
Pruritus genital	176.78	13.87	53	16798	2601	63469570
Sleep terror	176.27	13.87	53	16798	2627	63469544
Carotid artery occlusion	166.10	13.87	58	16793	4636	63467535
Atrial tachycardia	152.37	13.87	53	16798	4187	63467984
Tension headache	149.29	13.87	55	16796	5131	63467040
Anosmia	127.56	13.87	53	16798	6807	63465364

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cardiospasm	207.25	14.10	63	19246	1525	34936097
Palmoplantar keratoderma	190.36	14.10	62	19247	1891	34935731
Pruritus genital	179.07	14.10	61	19248	2143	34935479
Sleep terror	176.06	14.10	61	19248	2257	34935365
Tension headache	167.10	14.10	63	19246	2979	34934643
Atrial tachycardia	166.45	14.10	66	19243	3579	34934043
Facial pain	161.95	14.10	65	19244	3639	34933983
Myocardial infarction	159.50	14.10	259	19050	120826	34816796
Carotid artery occlusion	154.52	14.10	63	19246	3674	34933948
Anosmia	153.37	14.10	64	19245	3960	34933662

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cardiospasm	383.90	12.96	111	31359	3190	79709728
Palmoplantar keratoderma	366.59	12.96	110	31360	3606	79709312
Sleep terror	342.72	12.96	109	31361	4349	79708569
Pruritus genital	342.05	12.96	109	31361	4377	79708541
Myocardial infarction	341.28	12.96	391	31079	183738	79529180
Atrial tachycardia	310.96	12.96	114	31356	7019	79705899
Carotid artery occlusion	303.23	12.96	114	31356	7533	79705385
Tension headache	302.38	12.96	112	31358	7099	79705819
Anosmia	280.16	12.96	112	31358	8732	79704186
Subarachnoid haemorrhage	263.23	12.96	147	31323	24318	79688600

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
MeSH PA	D004232	Diuretics
MeSH PA	D004234	Diuretics, Osmotic
MeSH PA	D045283	Natriuretic Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Ocular hypertension	indication	4210003	DOID:9282

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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ID	Source
000687	NDDF
108478001	SNOMEDCT_US
386853004	SNOMEDCT_US
4018584	VUID
4018584	VANDF
4933	MMSL
5780	PUBCHEM_CID
6057	RXNORM
6433	INN_ID
C0022251	UMLSCUI

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Pharmaceutical products:

None