isoflurane 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
halogenated compounds used as general inhalation anaesthetics 1493 26675-46-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • isoflurane
  • 1-Chloro-2,2,2-trifluoroethyl difluoromethyl ether
  • forane
  • forene
  • isoforine
  • isorrane
A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
  • Molecular weight: 184.49
  • Formula: C3H2ClF5O
  • CLOGP: 1.95
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 0
  • TPSA: 9.23
  • ALOGS: -1.72
  • ROTB: 3

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 18, 1979 FDA BAXTER HLTHCARE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Propofol infusion syndrome 127.94 55.58 23 2137 743 50602221
Intra-abdominal pressure increased 125.82 55.58 19 2141 200 50602764
Mitochondrial DNA mutation 123.30 55.58 19 2141 231 50602733
Pneumatosis 119.94 55.58 20 2140 411 50602553
Intestinal ischaemia 105.19 55.58 29 2131 6728 50596236
Necrosis ischaemic 101.25 55.58 19 2141 780 50602184
Apnoea 95.20 55.58 27 2133 6939 50596025
Gene mutation 92.45 55.58 19 2141 1252 50601712
Hyperthermia malignant 90.02 55.58 17 2143 722 50602242
Blood gases abnormal 86.08 55.58 16 2144 623 50602341
Delayed recovery from anaesthesia 83.54 55.58 16 2144 733 50602231
Systemic inflammatory response syndrome 80.09 55.58 22 2138 5027 50597937
Exposure during pregnancy 78.46 55.58 54 2106 120961 50482003
Post procedural complication 70.92 55.58 26 2134 15078 50587886
Metabolic acidosis 64.61 55.58 32 2128 38793 50564171
Perforation 61.90 55.58 13 2147 951 50602013
Ultrasound ovary abnormal 60.27 55.58 9 2151 87 50602877
Hypotension 59.66 55.58 61 2099 235408 50367556
Blood lactic acid increased 55.84 55.58 17 2143 5568 50597396

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperthermia malignant 232.31 52.39 47 2027 1737 29570716
Apnoea 111.08 52.39 33 2041 6069 29566384
Post procedural complication 101.54 52.39 35 2039 10354 29562099
Hypotension 96.88 52.39 91 1983 194263 29378190
Intestinal ischaemia 91.26 52.39 29 2045 6663 29565790
Necrosis ischaemic 87.09 52.39 15 2059 223 29572230
Fear 81.28 52.39 29 2045 9475 29562978
Anhedonia 77.14 52.39 26 2048 7174 29565279
Superinfection 74.48 52.39 19 2055 1982 29570471
Injury 74.41 52.39 33 2041 19013 29553440
Renal injury 68.29 52.39 26 2048 10176 29562277
Mucosal ulceration 67.38 52.39 15 2059 873 29571580
Systemic inflammatory response syndrome 65.65 52.39 22 2052 5959 29566494
Emotional distress 60.51 52.39 26 2048 13869 29558584

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperthermia malignant 301.51 42.19 61 4180 2398 64492093
Intestinal ischaemia 207.74 42.19 61 4180 11488 64483003
Necrosis ischaemic 179.22 42.19 34 4207 949 64493542
Hypotension 149.04 42.19 152 4089 380822 64113669
Systemic inflammatory response syndrome 140.83 42.19 44 4197 10191 64484300
Propofol infusion syndrome 122.69 42.19 27 4214 1590 64492901
Intra-abdominal pressure increased 115.29 42.19 19 4222 228 64494263
Mitochondrial DNA mutation 114.39 42.19 19 4222 240 64494251
Fear 111.62 42.19 44 4197 20127 64474364
Renal injury 108.17 42.19 40 4201 15389 64479102
Delayed recovery from anaesthesia 107.59 42.19 24 4217 1504 64492987
Anhedonia 105.25 42.19 38 4203 13668 64480823
Pneumatosis 98.52 42.19 20 4221 796 64493695
Blood lactic acid increased 95.73 42.19 33 4208 10368 64484123
Metabolic acidosis 95.72 42.19 59 4182 70899 64423592
Gene mutation 79.87 42.19 20 4221 2062 64492429
Injury 79.17 42.19 48 4193 55944 64438547
Emotional distress 75.58 42.19 40 4201 35998 64458493
Blood gases abnormal 72.28 42.19 16 4225 967 64493524
Unevaluable event 68.08 42.19 42 4199 50447 64444044
Respiratory acidosis 67.04 42.19 25 4216 9830 64484661
Superinfection 63.17 42.19 19 4222 3867 64490624
Anaesthetic complication 61.53 42.19 17 4224 2562 64491929
Mucosal ulceration 58.39 42.19 15 4226 1712 64492779
Procedural hypotension 57.08 42.19 15 4226 1871 64492620
Ultrasound ovary abnormal 56.38 42.19 9 4232 87 64494404
Procedural complication 55.21 42.19 20 4221 7245 64487246
Perforation 54.03 42.19 13 4228 1135 64493356
Left ventricular hypertrophy 53.48 42.19 21 4220 9485 64485006
Renal failure 52.34 42.19 62 4179 181626 64312865
Multiple organ dysfunction syndrome 51.64 42.19 47 4194 101366 64393125
Bradycardia 49.19 42.19 49 4192 118170 64376321
Exposure during pregnancy 47.58 42.19 40 4201 77635 64416856
Blood creatine phosphokinase increased 46.22 42.19 35 4206 58523 64435968
Myotonia 42.26 42.19 8 4233 220 64494271

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N01AB06 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, GENERAL
Halogenated hydrocarbons
MeSH PA D000777 Anesthetics
MeSH PA D018685 Anesthetics, Inhalation
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
CHEBI has role CHEBI:38870 inhalation anesthetics
FDA EPC N0000175681 General Anesthetic
FDA PE N0000175975 General Anesthesia

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
General anesthesia indication 50697003
Hyperkalemia contraindication 14140009
Low blood pressure contraindication 45007003
Duchenne muscular dystrophy contraindication 76670001 DOID:11723
Disease of liver contraindication 235856003 DOID:409
Malignant hyperthermia contraindication 405501007




🐶 Veterinary Drug Use

SpeciesUseRelation
Dogs Induction and maintenance of general anesthesia Indication
Horses Induction and maintenance of general anesthesia Indication

🐶 Veterinary products

ProductApplicantIngredients
IsoFlo Zoetis Inc. 1
Isoflurane, USP Dechra Veterinary Products LLC 1
ATTANE Piramal Critical Care Inc. 1
Isoflurane, USP Piramal Enterprises Ltd. 1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor; anion channel Ion channel POSITIVE ALLOSTERIC MODULATOR CHEMBL CHEMBL
Potassium channel subfamily K member 2 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 3 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 9 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 10 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 18 Ion channel OPENER CHEMBL CHEMBL
Glycine receptor (alpha-1/beta) Ion channel POSITIVE MODULATOR CHEMBL CHEMBL
5-hydroxytryptamine receptor 2B GPCR Ki 5.11 PDSP

External reference:

IDSource
4019107 VUID
N0000147364 NUI
D00545 KEGG_DRUG
4019107 VANDF
C0022180 UMLSCUI
CHEBI:6015 CHEBI
ICF PDB_CHEM_ID
CHEMBL1256 ChEMBL_ID
DB00753 DRUGBANK_ID
D007530 MESH_DESCRIPTOR_UI
3763 PUBCHEM_CID
3286 INN_ID
2505 IUPHAR_LIGAND_ID
CYS9AKD70P UNII
6026 RXNORM
284 MMSL
4326 MMSL
4926 MMSL
d00267 MMSL
001391 NDDF
387368002 SNOMEDCT_US
66492008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
FORANE HUMAN PRESCRIPTION DRUG LABEL 1 10019-360 INHALANT 1 mL RESPIRATORY (INHALATION) NDA 22 sections
Isoflurane HUMAN PRESCRIPTION DRUG LABEL 1 12164-012 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 22 sections
Terrell HUMAN PRESCRIPTION DRUG LABEL 1 66794-011 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 13 sections
Terrell HUMAN PRESCRIPTION DRUG LABEL 1 66794-011 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 13 sections
Isoflurane HUMAN PRESCRIPTION DRUG LABEL 1 66794-017 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 21 sections
Terrell HUMAN PRESCRIPTION DRUG LABEL 1 66794-019 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 21 sections
Terrell HUMAN PRESCRIPTION DRUG LABEL 1 66794-019 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 21 sections
Isoflurane HUMAN PRESCRIPTION DRUG LABEL 1 66794-020 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 13 sections
Isoflurane HUMAN PRESCRIPTION DRUG LABEL 1 66794-020 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 13 sections