isoflurane 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
halogenated compounds used as general inhalation anaesthetics 1493 26675-46-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • isoflurane
  • 1-Chloro-2,2,2-trifluoroethyl difluoromethyl ether
  • forane
  • forene
  • isoforine
  • isorrane
A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
  • Molecular weight: 184.49
  • Formula: C3H2ClF5O
  • CLOGP: 1.95
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 0
  • TPSA: 9.23
  • ALOGS: -1.72
  • ROTB: 3

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 18, 1979 FDA BAXTER HLTHCARE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Mitochondrial DNA mutation 153.36 61.26 24 2294 338 56289411
Propofol infusion syndrome 139.31 61.26 25 2293 830 56288919
Intra-abdominal pressure increased 126.49 61.26 19 2299 200 56289549
Pneumatosis 120.65 61.26 20 2298 411 56289338
Status epilepticus 115.00 61.26 37 2281 15104 56274645
Gene mutation 108.18 61.26 22 2296 1427 56288322
Intestinal ischaemia 105.38 61.26 29 2289 6926 56282823
Blood gases abnormal 103.67 61.26 19 2299 710 56289039
Necrosis ischaemic 101.46 61.26 19 2299 800 56288949
Apnoea 95.11 61.26 27 2291 7215 56282534
Hyperthermia malignant 90.35 61.26 17 2301 734 56289015
Delayed recovery from anaesthesia 83.92 61.26 16 2302 742 56289007
Systemic inflammatory response syndrome 79.90 61.26 22 2296 5256 56284493
Exposure during pregnancy 76.66 61.26 55 2263 136287 56153462
Metabolic acidosis 73.48 61.26 35 2283 40419 56249330
Post procedural complication 70.89 61.26 26 2292 15640 56274109
Blood lactic acid increased 68.00 61.26 20 2298 6044 56283705
Perforation 61.31 61.26 13 2305 1033 56288716

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperthermia malignant 234.83 54.51 48 2099 1936 31693261
Apnoea 111.26 54.51 33 2114 6249 31688948
Post procedural complication 102.01 54.51 35 2112 10571 31684626
Hypotension 99.38 54.51 93 2054 204525 31490672
Intestinal ischaemia 90.78 54.51 29 2118 7016 31688181
Necrosis ischaemic 87.48 54.51 15 2132 225 31694972
Fear 80.89 54.51 29 2118 9945 31685252
Anhedonia 77.18 54.51 26 2121 7416 31687781
Injury 74.42 54.51 33 2114 19676 31675521
Superinfection 73.19 54.51 19 2128 2199 31692998
Renal injury 68.04 54.51 26 2121 10639 31684558
Mucosal ulceration 67.08 54.51 15 2132 923 31694274
Systemic inflammatory response syndrome 65.53 54.51 22 2125 6203 31688994
Emotional distress 60.56 54.51 26 2121 14330 31680867

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperthermia malignant 305.31 44.99 62 4399 2599 70921384
Intestinal ischaemia 207.77 44.99 61 4400 12003 70911980
Necrosis ischaemic 180.01 44.99 34 4427 970 70923013
Hypotension 152.49 44.99 155 4306 404226 70519757
Mitochondrial DNA mutation 142.68 44.99 24 4437 345 70923638
Systemic inflammatory response syndrome 140.77 44.99 44 4417 10668 70913315
Propofol infusion syndrome 133.20 44.99 29 4432 1700 70922283
Intra-abdominal pressure increased 116.13 44.99 19 4442 228 70923755
Fear 112.17 44.99 44 4417 20767 70903216
Metabolic acidosis 108.53 44.99 64 4397 74282 70849701
Renal injury 108.25 44.99 40 4421 16054 70907929
Delayed recovery from anaesthesia 108.20 44.99 24 4437 1533 70922450
Blood lactic acid increased 106.55 44.99 36 4425 11137 70912846
Anhedonia 105.54 44.99 38 4423 14175 70909808
Pneumatosis 99.16 44.99 20 4441 806 70923177
Gene mutation 93.88 44.99 23 4438 2268 70921715
Blood gases abnormal 87.91 44.99 19 4442 1075 70922908
Emotional distress 76.07 44.99 40 4421 37148 70886835
Status epilepticus 75.94 44.99 35 4426 24491 70899492
Respiratory acidosis 74.48 44.99 27 4434 10254 70913729
Injury 74.37 44.99 48 4413 65197 70858786
Unevaluable event 68.61 44.99 42 4419 52021 70871962
Anaesthetic complication 66.58 44.99 18 4443 2618 70921365
Superinfection 62.51 44.99 19 4442 4187 70919796
Mucosal ulceration 58.43 44.99 15 4446 1786 70922197
Procedural hypotension 57.12 44.99 15 4446 1951 70922032
Ultrasound ovary abnormal 56.78 44.99 9 4452 87 70923896
Procedural complication 55.42 44.99 20 4441 7494 70916489
Perforation 53.35 44.99 13 4448 1252 70922731
Blood creatine phosphokinase increased 52.96 44.99 38 4423 61225 70862758
Left ventricular hypertrophy 52.94 44.99 21 4440 10181 70913802
Bradycardia 52.57 44.99 51 4410 124564 70799419
Renal failure 52.56 44.99 62 4399 189008 70734975
Multiple organ dysfunction syndrome 50.70 44.99 47 4414 108468 70815515
Shock 49.16 44.99 31 4430 40394 70883589
Exposure during pregnancy 46.90 44.99 41 4420 87676 70836307
CSF oligoclonal band present 46.69 44.99 9 4452 286 70923697

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N01AB06 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, GENERAL
Halogenated hydrocarbons
MeSH PA D000777 Anesthetics
MeSH PA D018685 Anesthetics, Inhalation
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
CHEBI has role CHEBI:38870 inhalation anesthetics
FDA EPC N0000175681 General Anesthetic
FDA PE N0000175975 General Anesthesia

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
General anesthesia indication 50697003
Hyperkalemia contraindication 14140009
Low blood pressure contraindication 45007003
Duchenne muscular dystrophy contraindication 76670001 DOID:11723
Disease of liver contraindication 235856003 DOID:409
Malignant hyperthermia contraindication 405501007




🐶 Veterinary Drug Use

SpeciesUseRelation
Dogs Induction and maintenance of general anesthesia Indication
Horses Induction and maintenance of general anesthesia Indication

🐶 Veterinary products

ProductApplicantIngredients
IsoFlo Zoetis Inc. 1
Isoflurane, USP Dechra Veterinary Products LLC 1
ATTANE Piramal Critical Care Inc. 1
Isoflurane, USP Piramal Enterprises Ltd. 1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor; anion channel Ion channel POSITIVE ALLOSTERIC MODULATOR CHEMBL CHEMBL
Potassium channel subfamily K member 2 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 3 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 9 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 10 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 18 Ion channel OPENER CHEMBL CHEMBL
Glycine receptor (alpha-1/beta) Ion channel POSITIVE MODULATOR CHEMBL CHEMBL
5-hydroxytryptamine receptor 2B GPCR Ki 5.11 PDSP

External reference:

IDSource
4019107 VUID
N0000147364 NUI
D00545 KEGG_DRUG
4019107 VANDF
C0022180 UMLSCUI
CHEBI:6015 CHEBI
ICF PDB_CHEM_ID
CHEMBL1256 ChEMBL_ID
DB00753 DRUGBANK_ID
D007530 MESH_DESCRIPTOR_UI
3763 PUBCHEM_CID
3286 INN_ID
2505 IUPHAR_LIGAND_ID
CYS9AKD70P UNII
6026 RXNORM
284 MMSL
4326 MMSL
4926 MMSL
d00267 MMSL
001391 NDDF
387368002 SNOMEDCT_US
66492008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
FORANE HUMAN PRESCRIPTION DRUG LABEL 1 10019-360 INHALANT 1 mL RESPIRATORY (INHALATION) NDA 23 sections
FORANE HUMAN PRESCRIPTION DRUG LABEL 1 10019-360 INHALANT 1 mL RESPIRATORY (INHALATION) NDA 23 sections
Isoflurane HUMAN PRESCRIPTION DRUG LABEL 1 12164-012 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 22 sections
Terrell HUMAN PRESCRIPTION DRUG LABEL 1 66794-011 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 13 sections
Terrell HUMAN PRESCRIPTION DRUG LABEL 1 66794-011 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 13 sections
Terrell HUMAN PRESCRIPTION DRUG LABEL 1 66794-011 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 13 sections
Isoflurane HUMAN PRESCRIPTION DRUG LABEL 1 66794-017 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 21 sections
Isoflurane HUMAN PRESCRIPTION DRUG LABEL 1 66794-017 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 21 sections
Terrell HUMAN PRESCRIPTION DRUG LABEL 1 66794-019 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 21 sections
Terrell HUMAN PRESCRIPTION DRUG LABEL 1 66794-019 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 21 sections
Isoflurane HUMAN PRESCRIPTION DRUG LABEL 1 66794-020 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 13 sections
Isoflurane HUMAN PRESCRIPTION DRUG LABEL 1 66794-020 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 13 sections
Isoflurane HUMAN PRESCRIPTION DRUG LABEL 1 66794-020 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 13 sections