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isocarboxazid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1490 | 59-63-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An MAO inhibitor that is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in the treatment of panic disorder and the phobic disorders. (From AMA, Drug Evaluations Annual, 1994, p311)
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 15 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Hosey CM, Chan R, Benet LZ |
| S (Water solubility) | 0.80 mg/mL | Bocci G, Oprea TI, Benet LZ |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK1,JAK2,MAP3K21,MAP3K7,MAPK7,MAPK9,MARK4,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CD,PRKCD,PRKDC,SIK2,SIK3,STK33,TEK,TTK | 38 | |||
| kinase-selectivity-class | AXL,BRAF,ERBB2,GRK2,MAPK7,MARK4 | 6 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| July 1, 1959 | FDA | VALIDUS PHARMS INC |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N06AF01 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Monoamine oxidase inhibitors, non-selective |
| FDA MoA | N0000000184 | Monoamine Oxidase Inhibitors |
| MeSH PA | D000928 | Antidepressive Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D008996 | Monoamine Oxidase Inhibitors |
| MeSH PA | D011619 | Psychotropic Drugs |
| FDA EPC | N0000175744 | Monoamine Oxidase Inhibitor |
Related Drugs by ATC class:
N06AF Monoamine oxidase inhibitors, non-selective 5 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Major depressive disorder | indication | 370143000 | |
| Suicidal thoughts | contraindication | 6471006 | |
| Alcoholism | contraindication | 7200002 | |
| Bipolar disorder | contraindication | 13746004 | DOID:3312 |
| Feeling agitated | contraindication | 24199005 | |
| Orthostatic hypotension | contraindication | 28651003 | |
| Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Conduction disorder of the heart | contraindication | 44808001 | |
| Low blood pressure | contraindication | 45007003 | |
| Chronic heart failure | contraindication | 48447003 | |
| Anxiety | contraindication | 48694002 | |
| Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
| Schizophrenia | contraindication | 58214004 | DOID:5419 |
| Cerebrovascular disease | contraindication | 62914000 | DOID:6713 |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Seizure disorder | contraindication | 128613002 | |
| Liver function tests abnormal | contraindication | 166603001 | |
| Angina pectoris | contraindication | 194828000 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Hypoglycemic disorder | contraindication | 237630007 | |
| Syncope | contraindication | 271594007 | |
| Pheochromocytoma | contraindication | 302835009 | |
| Myelogram | contraindication | 367401004 | |
| Disorder of coronary artery | contraindication | 414024009 | |
| Severe Headache Disorder | contraindication | ||
| Hypertensive Emergencies | contraindication | ||
| Frequent Headache Disorder | contraindication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 10.55 | acidic |
| pKa2 | 0.0 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Amine oxidase [flavin-containing] B | Enzyme | INHIBITOR | DRUGBANK | CHEMBL | |||||
| Amine oxidase [flavin-containing] A | Enzyme | INHIBITOR | DRUGBANK | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4017782 | VUID |
| N0000146143 | NUI |
| D02580 | KEGG_DRUG |
| 4017782 | VANDF |
| C0022154 | UMLSCUI |
| CHEBI:93635 | CHEBI |
| CHEMBL1201168 | ChEMBL_ID |
| DB01247 | DRUGBANK_ID |
| D007520 | MESH_DESCRIPTOR_UI |
| 3759 | PUBCHEM_CID |
| 7204 | IUPHAR_LIGAND_ID |
| 1071 | INN_ID |
| 34237V843T | UNII |
| 152005 | RXNORM |
| 4923 | MMSL |
| 6096 | MMSL |
| d00882 | MMSL |
| 001493 | NDDF |
| 29877002 | SNOMEDCT_US |
| 387161000 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Marplan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 30698-032 | TABLET | 10 mg | ORAL | NDA | 24 sections |
| MARPLAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 72336-032 | TABLET | 10 mg | ORAL | NDA | 24 sections |
| Marplan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 72604-032 | TABLET | 10 mg | ORAL | Unapproved drug for use in drug shortage | 2 sections |