isocarboxazid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1490 59-63-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • marplan
  • Ro 5-0831/1
  • Ro 5-0831
  • isocarboxazid
  • benazide
  • isocarboxazide
  • isocarboxyzid
An MAO inhibitor that is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in the treatment of panic disorder and the phobic disorders. (From AMA, Drug Evaluations Annual, 1994, p311)
  • Molecular weight: 231.26
  • Formula: C12H13N3O2
  • CLOGP: 0.99
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 67.16
  • ALOGS: -3.01
  • ROTB: 4

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
15 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Hosey CM, Chan R, Benet LZ
S (Water solubility) 0.80 mg/mL Bocci G, Oprea TI, Benet LZ

Approvals:

DateAgencyCompanyOrphan
July 1, 1959 FDA VALIDUS PHARMS INC

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N06AF01 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Monoamine oxidase inhibitors, non-selective
FDA MoA N0000000184 Monoamine Oxidase Inhibitors
MeSH PA D000928 Antidepressive Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D008996 Monoamine Oxidase Inhibitors
MeSH PA D011619 Psychotropic Drugs
FDA EPC N0000175744 Monoamine Oxidase Inhibitor

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Major depressive disorder indication 370143000
Suicidal thoughts contraindication 6471006
Alcoholism contraindication 7200002
Bipolar disorder contraindication 13746004 DOID:3312
Feeling agitated contraindication 24199005
Orthostatic hypotension contraindication 28651003
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Anxiety contraindication 48694002
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Schizophrenia contraindication 58214004 DOID:5419
Cerebrovascular disease contraindication 62914000 DOID:6713
Diabetes mellitus contraindication 73211009 DOID:9351
Kidney disease contraindication 90708001 DOID:557
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Angina pectoris contraindication 194828000
Disease of liver contraindication 235856003 DOID:409
Hypoglycemic disorder contraindication 237630007
Syncope contraindication 271594007
Pheochromocytoma contraindication 302835009
Myelogram contraindication 367401004
Disorder of coronary artery contraindication 414024009
Severe Headache Disorder contraindication
Hypertensive Emergencies contraindication
Frequent Headache Disorder contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.55 acidic
pKa2 0.0 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Amine oxidase [flavin-containing] B Enzyme INHIBITOR DRUGBANK CHEMBL
Amine oxidase [flavin-containing] A Enzyme INHIBITOR DRUGBANK CHEMBL

External reference:

IDSource
4017782 VUID
N0000146143 NUI
D02580 KEGG_DRUG
4017782 VANDF
C0022154 UMLSCUI
CHEBI:93635 CHEBI
CHEMBL1201168 ChEMBL_ID
DB01247 DRUGBANK_ID
D007520 MESH_DESCRIPTOR_UI
3759 PUBCHEM_CID
7204 IUPHAR_LIGAND_ID
1071 INN_ID
34237V843T UNII
152005 RXNORM
4923 MMSL
6096 MMSL
d00882 MMSL
001493 NDDF
29877002 SNOMEDCT_US
387161000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Marplan HUMAN PRESCRIPTION DRUG LABEL 1 30698-032 TABLET 10 mg ORAL NDA 24 sections
Marplan HUMAN PRESCRIPTION DRUG LABEL 1 30698-032 TABLET 10 mg ORAL NDA 24 sections
Marplan HUMAN PRESCRIPTION DRUG LABEL 1 72604-032 TABLET 10 mg ORAL Unapproved drug for use in drug shortage 2 sections