Stem definition | Drug id | CAS RN |
---|---|---|
1490 | 59-63-2 |
Dose | Unit | Route |
---|---|---|
15 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Hosey CM, Chan R, Benet LZ |
S (Water solubility) | 0.80 mg/mL | Bocci G, Oprea TI, Benet LZ |
Date | Agency | Company | Orphan |
---|---|---|---|
July 1, 1959 | FDA | VALIDUS PHARMS INC |
None
None
None
None
Source | Code | Description |
---|---|---|
ATC | N06AF01 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Monoamine oxidase inhibitors, non-selective |
FDA MoA | N0000000184 | Monoamine Oxidase Inhibitors |
MeSH PA | D000928 | Antidepressive Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D008996 | Monoamine Oxidase Inhibitors |
MeSH PA | D011619 | Psychotropic Drugs |
FDA EPC | N0000175744 | Monoamine Oxidase Inhibitor |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Major depressive disorder | indication | 370143000 | |
Suicidal thoughts | contraindication | 6471006 | |
Alcoholism | contraindication | 7200002 | |
Bipolar disorder | contraindication | 13746004 | DOID:3312 |
Feeling agitated | contraindication | 24199005 | |
Orthostatic hypotension | contraindication | 28651003 | |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Conduction disorder of the heart | contraindication | 44808001 | |
Low blood pressure | contraindication | 45007003 | |
Chronic heart failure | contraindication | 48447003 | |
Anxiety | contraindication | 48694002 | |
Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
Schizophrenia | contraindication | 58214004 | DOID:5419 |
Cerebrovascular disease | contraindication | 62914000 | DOID:6713 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Seizure disorder | contraindication | 128613002 | |
Liver function tests abnormal | contraindication | 166603001 | |
Angina pectoris | contraindication | 194828000 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Hypoglycemic disorder | contraindication | 237630007 | |
Syncope | contraindication | 271594007 | |
Pheochromocytoma | contraindication | 302835009 | |
Myelogram | contraindication | 367401004 | |
Disorder of coronary artery | contraindication | 414024009 | |
Severe Headache Disorder | contraindication | ||
Hypertensive Emergencies | contraindication | ||
Frequent Headache Disorder | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 10.55 | acidic |
pKa2 | 0.0 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Amine oxidase [flavin-containing] B | Enzyme | INHIBITOR | DRUGBANK | CHEMBL | |||||
Amine oxidase [flavin-containing] A | Enzyme | INHIBITOR | DRUGBANK | CHEMBL |
ID | Source |
---|---|
4017782 | VUID |
N0000146143 | NUI |
D02580 | KEGG_DRUG |
4017782 | VANDF |
C0022154 | UMLSCUI |
CHEBI:93635 | CHEBI |
CHEMBL1201168 | ChEMBL_ID |
DB01247 | DRUGBANK_ID |
D007520 | MESH_DESCRIPTOR_UI |
3759 | PUBCHEM_CID |
7204 | IUPHAR_LIGAND_ID |
1071 | INN_ID |
34237V843T | UNII |
152005 | RXNORM |
4923 | MMSL |
6096 | MMSL |
d00882 | MMSL |
001493 | NDDF |
29877002 | SNOMEDCT_US |
387161000 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Marplan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 30698-032 | TABLET | 10 mg | ORAL | NDA | 24 sections |
Marplan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 30698-032 | TABLET | 10 mg | ORAL | NDA | 24 sections |
Marplan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 72604-032 | TABLET | 10 mg | ORAL | Unapproved drug for use in drug shortage | 2 sections |