ipratropium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| atropine derivatives | 1475 | 60205-81-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A muscarinic antagonist structurally related to ATROPINE but often considered safer and more effective for inhalation use. It is used for various bronchial disorders, in rhinitis, and as an antiarrhythmic.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.24 | mg | N |
| 0.12 | mg | Inhal.aerosol |
| 0.12 | mg | Inhal.powder |
| 0.30 | mg | Inhal.solution |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 50 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.01 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 3 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 5.10 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 31.40 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.95 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 1.64 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 29, 1986 | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Asthma | 1287.45 | 10.87 | 1005 | 56755 | 126556 | 63304706 |
| Wheezing | 829.22 | 10.87 | 690 | 57070 | 94905 | 63336357 |
| Obstructive airways disorder | 580.70 | 10.87 | 311 | 57449 | 20388 | 63410874 |
| Chronic obstructive pulmonary disease | 494.91 | 10.87 | 429 | 57331 | 62257 | 63369005 |
| Dyspnoea | 480.94 | 10.87 | 1502 | 56258 | 659811 | 62771451 |
| Sleep disorder due to a general medical condition | 341.40 | 10.87 | 183 | 57577 | 12005 | 63419257 |
| Pneumonia | 254.40 | 10.87 | 951 | 56809 | 455816 | 62975446 |
| Cough | 254.23 | 10.87 | 710 | 57050 | 292033 | 63139229 |
| Productive cough | 245.35 | 10.87 | 295 | 57465 | 62913 | 63368349 |
| Chest discomfort | 222.52 | 10.87 | 376 | 57384 | 109593 | 63321669 |
| Full blood count abnormal | 222.16 | 10.87 | 203 | 57557 | 31514 | 63399748 |
| Drug intolerance | 186.52 | 10.87 | 29 | 57731 | 308632 | 63122630 |
| Alopecia | 161.53 | 10.87 | 53 | 57707 | 337483 | 63093779 |
| Contraindicated product administered | 161.50 | 10.87 | 9 | 57751 | 217639 | 63213623 |
| Synovitis | 144.22 | 10.87 | 6 | 57754 | 186912 | 63244350 |
| Systemic lupus erythematosus | 142.47 | 10.87 | 13 | 57747 | 208905 | 63222357 |
| Drug ineffective | 139.04 | 10.87 | 488 | 57272 | 1044277 | 62386985 |
| Pemphigus | 138.16 | 10.87 | 7 | 57753 | 183719 | 63247543 |
| Asthma-chronic obstructive pulmonary disease overlap syndrome | 132.73 | 10.87 | 55 | 57705 | 2006 | 63429256 |
| Glossodynia | 130.84 | 10.87 | 8 | 57752 | 178868 | 63252394 |
| Nasal congestion | 124.17 | 10.87 | 218 | 57542 | 65442 | 63365820 |
| Total lung capacity increased | 123.43 | 10.87 | 54 | 57706 | 2256 | 63429006 |
| Sputum discoloured | 123.06 | 10.87 | 109 | 57651 | 16238 | 63415024 |
| Arthropathy | 121.14 | 10.87 | 32 | 57728 | 234760 | 63196502 |
| Treatment failure | 119.47 | 10.87 | 19 | 57741 | 199024 | 63232238 |
| Bronchiectasis | 118.28 | 10.87 | 106 | 57654 | 16036 | 63415226 |
| Therapeutic product effect incomplete | 116.86 | 10.87 | 312 | 57448 | 124744 | 63306518 |
| Completed suicide | 114.67 | 10.87 | 4 | 57756 | 145669 | 63285593 |
| Respiratory failure | 113.83 | 10.87 | 272 | 57488 | 101586 | 63329676 |
| Rheumatoid arthritis | 111.00 | 10.87 | 46 | 57714 | 253773 | 63177489 |
| Cardiac murmur | 109.48 | 10.87 | 97 | 57663 | 14455 | 63416807 |
| Dyspnoea exertional | 108.60 | 10.87 | 196 | 57564 | 60106 | 63371156 |
| Nasal polyps | 106.10 | 10.87 | 67 | 57693 | 5972 | 63425290 |
| Breath sounds abnormal | 104.95 | 10.87 | 84 | 57676 | 10889 | 63420373 |
| Middle insomnia | 104.66 | 10.87 | 89 | 57671 | 12554 | 63418708 |
| Wound | 104.02 | 10.87 | 13 | 57747 | 163250 | 63268012 |
| Sleep apnoea syndrome | 101.74 | 10.87 | 129 | 57631 | 29004 | 63402258 |
| Loss of personal independence in daily activities | 96.25 | 10.87 | 248 | 57512 | 97042 | 63334220 |
| Bronchial neoplasm | 91.96 | 10.87 | 29 | 57731 | 471 | 63430791 |
| Nasal turbinate hypertrophy | 91.29 | 10.87 | 32 | 57728 | 731 | 63430531 |
| Joint swelling | 90.32 | 10.87 | 99 | 57661 | 327567 | 63103695 |
| Rales | 90.31 | 10.87 | 82 | 57678 | 12615 | 63418647 |
| Infusion related reaction | 90.14 | 10.87 | 56 | 57704 | 245465 | 63185797 |
| Gastrooesophageal reflux disease | 88.70 | 10.87 | 238 | 57522 | 95401 | 63335861 |
| Pericarditis | 87.52 | 10.87 | 9 | 57751 | 131570 | 63299692 |
| Bronchial haemorrhage | 87.14 | 10.87 | 29 | 57731 | 563 | 63430699 |
| Off label use | 86.68 | 10.87 | 319 | 57441 | 674143 | 62757119 |
| Vocal cord dysfunction | 84.85 | 10.87 | 28 | 57732 | 529 | 63430733 |
| Maternal exposure during pregnancy | 83.86 | 10.87 | 48 | 57712 | 220014 | 63211248 |
| Hyper IgE syndrome | 83.19 | 10.87 | 27 | 57733 | 483 | 63430779 |
| Blood test abnormal | 83.05 | 10.87 | 86 | 57674 | 15543 | 63415719 |
| Rhinitis allergic | 81.97 | 10.87 | 75 | 57685 | 11652 | 63419610 |
| Discomfort | 80.45 | 10.87 | 26 | 57734 | 167348 | 63263914 |
| Bronchitis | 80.10 | 10.87 | 273 | 57487 | 124662 | 63306600 |
| Toxicity to various agents | 79.47 | 10.87 | 65 | 57695 | 247185 | 63184077 |
| Abdominal discomfort | 78.84 | 10.87 | 106 | 57654 | 320779 | 63110483 |
| Rhonchi | 78.70 | 10.87 | 41 | 57719 | 2535 | 63428727 |
| Therapeutic product effect decreased | 78.20 | 10.87 | 39 | 57721 | 193148 | 63238114 |
| Ventricular failure | 77.87 | 10.87 | 24 | 57736 | 360 | 63430902 |
| Acute respiratory failure | 77.86 | 10.87 | 124 | 57636 | 34361 | 63396901 |
| Sarcoidosis | 75.63 | 10.87 | 58 | 57702 | 7064 | 63424198 |
| Respiration abnormal | 74.22 | 10.87 | 55 | 57705 | 6362 | 63424900 |
| Upper-airway cough syndrome | 73.97 | 10.87 | 70 | 57690 | 11348 | 63419914 |
| Blood immunoglobulin E increased | 73.42 | 10.87 | 45 | 57715 | 3804 | 63427458 |
| Endometrial ablation | 73.34 | 10.87 | 29 | 57731 | 935 | 63430327 |
| Arthralgia | 72.76 | 10.87 | 270 | 57490 | 569440 | 62861822 |
| Anti-cyclic citrullinated peptide antibody positive | 72.22 | 10.87 | 10 | 57750 | 116202 | 63315060 |
| Oesophageal spasm | 71.30 | 10.87 | 41 | 57719 | 3082 | 63428180 |
| Hypercapnia | 70.68 | 10.87 | 50 | 57710 | 5381 | 63425881 |
| Total lung capacity decreased | 70.30 | 10.87 | 36 | 57724 | 2147 | 63429115 |
| Prolonged expiration | 69.74 | 10.87 | 29 | 57731 | 1067 | 63430195 |
| Eosinophilia | 68.98 | 10.87 | 94 | 57666 | 22662 | 63408600 |
| Swelling | 68.61 | 10.87 | 90 | 57670 | 275288 | 63155974 |
| Pain | 68.53 | 10.87 | 395 | 57365 | 740233 | 62691029 |
| Bronchospasm | 67.56 | 10.87 | 81 | 57679 | 17199 | 63414063 |
| Haemoptysis | 67.21 | 10.87 | 105 | 57655 | 28621 | 63402641 |
| Hypoxia | 67.11 | 10.87 | 160 | 57600 | 59632 | 63371630 |
| Rhinitis | 66.71 | 10.87 | 66 | 57694 | 11300 | 63419962 |
| Helicobacter infection | 65.34 | 10.87 | 5 | 57755 | 92780 | 63338482 |
| Forced expiratory volume decreased | 65.26 | 10.87 | 46 | 57714 | 4922 | 63426340 |
| Bronchial disorder | 65.19 | 10.87 | 29 | 57731 | 1261 | 63430001 |
| Restrictive pulmonary disease | 64.85 | 10.87 | 32 | 57728 | 1763 | 63429499 |
| Upper respiratory tract infection | 64.16 | 10.87 | 192 | 57568 | 81855 | 63349407 |
| Rib deformity | 63.25 | 10.87 | 19 | 57741 | 260 | 63431002 |
| Oesophageal pain | 62.37 | 10.87 | 40 | 57720 | 3661 | 63427601 |
| Heart sounds | 62.19 | 10.87 | 26 | 57734 | 970 | 63430292 |
| Myocardial infarction | 60.29 | 10.87 | 214 | 57546 | 99679 | 63331583 |
| Rash | 57.97 | 10.87 | 288 | 57472 | 560583 | 62870679 |
| Bronchopulmonary aspergillosis allergic | 57.93 | 10.87 | 32 | 57728 | 2226 | 63429036 |
| Laryngeal stenosis | 56.94 | 10.87 | 25 | 57735 | 1053 | 63430209 |
| Throat clearing | 55.87 | 10.87 | 32 | 57728 | 2387 | 63428875 |
| Oxygen saturation decreased | 54.51 | 10.87 | 191 | 57569 | 88394 | 63342868 |
| Breast conserving surgery | 54.35 | 10.87 | 24 | 57736 | 1025 | 63430237 |
| Sinus disorder | 53.66 | 10.87 | 87 | 57673 | 24466 | 63406796 |
| Dysphonia | 51.91 | 10.87 | 126 | 57634 | 47488 | 63383774 |
| Exposure during pregnancy | 51.06 | 10.87 | 40 | 57720 | 155507 | 63275755 |
| Tachypnoea | 50.22 | 10.87 | 70 | 57690 | 17232 | 63414030 |
| Psoriatic arthropathy | 50.04 | 10.87 | 11 | 57749 | 91509 | 63339753 |
| Blister | 48.45 | 10.87 | 29 | 57731 | 129785 | 63301477 |
| Product use issue | 48.12 | 10.87 | 79 | 57681 | 220441 | 63210821 |
| PO2 decreased | 46.09 | 10.87 | 24 | 57736 | 1482 | 63429780 |
| Jaundice cholestatic | 45.73 | 10.87 | 44 | 57716 | 7280 | 63423982 |
| Hepatic enzyme increased | 45.54 | 10.87 | 71 | 57689 | 202257 | 63229005 |
| Irritable bowel syndrome | 44.87 | 10.87 | 10 | 57750 | 82402 | 63348860 |
| Lung neoplasm malignant | 43.50 | 10.87 | 70 | 57690 | 19563 | 63411699 |
| Lower respiratory tract infection | 43.38 | 10.87 | 236 | 57524 | 132071 | 63299191 |
| Hypomania | 43.30 | 10.87 | 40 | 57720 | 6290 | 63424972 |
| Lung opacity | 43.17 | 10.87 | 30 | 57730 | 3138 | 63428124 |
| Nasal obstruction | 42.95 | 10.87 | 24 | 57736 | 1707 | 63429555 |
| Sight disability | 42.42 | 10.87 | 12 | 57748 | 131 | 63431131 |
| PCO2 increased | 41.55 | 10.87 | 21 | 57739 | 1218 | 63430044 |
| Sinus tachycardia | 41.29 | 10.87 | 77 | 57683 | 24191 | 63407071 |
| Respiratory rate increased | 40.79 | 10.87 | 56 | 57704 | 13592 | 63417670 |
| Oedema peripheral | 40.41 | 10.87 | 303 | 57457 | 189208 | 63242054 |
| Respiratory disorder | 40.04 | 10.87 | 101 | 57659 | 38981 | 63392281 |
| Lymphoedema | 39.59 | 10.87 | 51 | 57709 | 11641 | 63419621 |
| Aspiration | 39.39 | 10.87 | 49 | 57711 | 10802 | 63420460 |
| Intentional product use issue | 39.36 | 10.87 | 35 | 57725 | 127857 | 63303405 |
| Venous pressure jugular increased | 39.20 | 10.87 | 16 | 57744 | 561 | 63430701 |
| Thermohypoaesthesia | 38.73 | 10.87 | 11 | 57749 | 122 | 63431140 |
| Influenza B virus test positive | 38.70 | 10.87 | 13 | 57747 | 260 | 63431002 |
| Lung hyperinflation | 37.82 | 10.87 | 20 | 57740 | 1275 | 63429987 |
| Cardiac failure congestive | 37.42 | 10.87 | 175 | 57585 | 92258 | 63339004 |
| Impaired healing | 36.75 | 10.87 | 24 | 57736 | 102518 | 63328744 |
| Granuloma | 36.71 | 10.87 | 35 | 57725 | 5726 | 63425536 |
| Reversible airways obstruction | 36.32 | 10.87 | 22 | 57738 | 1820 | 63429442 |
| Sleep disorder due to general medical condition, insomnia type | 36.24 | 10.87 | 3 | 57757 | 52214 | 63379048 |
| Infective exacerbation of chronic obstructive airways disease | 35.54 | 10.87 | 19 | 57741 | 1238 | 63430024 |
| Status asthmaticus | 35.31 | 10.87 | 17 | 57743 | 887 | 63430375 |
| Drug abuse | 35.30 | 10.87 | 11 | 57749 | 72507 | 63358755 |
| Blood insulin abnormal | 35.18 | 10.87 | 8 | 57752 | 32 | 63431230 |
| FEV1/FVC ratio decreased | 34.96 | 10.87 | 10 | 57750 | 114 | 63431148 |
| Tracheomalacia | 34.36 | 10.87 | 11 | 57749 | 188 | 63431074 |
| Pulmonary hypertension | 34.00 | 10.87 | 92 | 57668 | 37031 | 63394231 |
| Infective pulmonary exacerbation of cystic fibrosis | 33.92 | 10.87 | 41 | 57719 | 8776 | 63422486 |
| Airway peak pressure increased | 33.87 | 10.87 | 12 | 57748 | 283 | 63430979 |
| Respiratory distress | 32.98 | 10.87 | 86 | 57674 | 33865 | 63397397 |
| Dyslipidaemia | 32.82 | 10.87 | 37 | 57723 | 7356 | 63423906 |
| Multimorbidity | 32.11 | 10.87 | 14 | 57746 | 580 | 63430682 |
| Polycystic ovaries | 32.04 | 10.87 | 29 | 57731 | 4442 | 63426820 |
| Respiratory tract infection | 31.40 | 10.87 | 96 | 57664 | 41387 | 63389875 |
| Affective disorder | 31.18 | 10.87 | 33 | 57727 | 6113 | 63425149 |
| Heart rate increased | 30.81 | 10.87 | 168 | 57592 | 94070 | 63337192 |
| Pneumonia viral | 30.74 | 10.87 | 37 | 57723 | 7885 | 63423377 |
| Diarrhoea | 30.47 | 10.87 | 463 | 57297 | 714903 | 62716359 |
| Respiratory gas exchange disorder | 30.37 | 10.87 | 12 | 57748 | 386 | 63430876 |
| Depressive symptom | 30.17 | 10.87 | 27 | 57733 | 4075 | 63427187 |
| Skin lesion | 30.03 | 10.87 | 78 | 57682 | 30643 | 63400619 |
| Hip arthroplasty | 29.83 | 10.87 | 4 | 57756 | 47642 | 63383620 |
| Bundle branch block left | 29.09 | 10.87 | 34 | 57726 | 7025 | 63424237 |
| C-reactive protein abnormal | 28.55 | 10.87 | 4 | 57756 | 46092 | 63385170 |
| Schizophrenia | 28.49 | 10.87 | 40 | 57720 | 9912 | 63421350 |
| Coronary artery disease | 27.44 | 10.87 | 78 | 57682 | 32299 | 63398963 |
| Fatigue | 27.42 | 10.87 | 608 | 57152 | 887420 | 62543842 |
| Drug hypersensitivity | 27.36 | 10.87 | 168 | 57592 | 310519 | 63120743 |
| Atrial fibrillation | 26.85 | 10.87 | 190 | 57570 | 116446 | 63314816 |
| Red blood cell sedimentation rate increased | 26.81 | 10.87 | 4 | 57756 | 43978 | 63387284 |
| Gastrointestinal disorder | 26.80 | 10.87 | 49 | 57711 | 131190 | 63300072 |
| Lactose intolerance | 26.79 | 10.87 | 22 | 57738 | 2956 | 63428306 |
| Cyanosis | 26.67 | 10.87 | 52 | 57708 | 16883 | 63414379 |
| Asthmatic crisis | 26.67 | 10.87 | 18 | 57742 | 1795 | 63429467 |
| Liver injury | 26.36 | 10.87 | 11 | 57749 | 60509 | 63370753 |
| Separation anxiety disorder | 26 | 10.87 | 6 | 57754 | 26 | 63431236 |
| Chest X-ray abnormal | 25.92 | 10.87 | 26 | 57734 | 4523 | 63426739 |
| Kyphosis | 25.48 | 10.87 | 20 | 57740 | 2520 | 63428742 |
| Respiratory acidosis | 25.47 | 10.87 | 31 | 57729 | 6684 | 63424578 |
| Toxic epidermal necrolysis | 25.46 | 10.87 | 65 | 57695 | 25269 | 63405993 |
| Crystal arthropathy | 25.18 | 10.87 | 10 | 57750 | 326 | 63430936 |
| Blood pH decreased | 25.15 | 10.87 | 20 | 57740 | 2567 | 63428695 |
| Appetite disorder | 24.89 | 10.87 | 32 | 57728 | 7289 | 63423973 |
| Sinusitis | 24.78 | 10.87 | 315 | 57445 | 226338 | 63204924 |
| Liver disorder | 24.63 | 10.87 | 9 | 57751 | 53678 | 63377584 |
| Intentional overdose | 24.41 | 10.87 | 19 | 57741 | 74133 | 63357129 |
| Rhinorrhoea | 24.26 | 10.87 | 121 | 57639 | 65456 | 63365806 |
| Blood cholesterol increased | 24.14 | 10.87 | 30 | 57730 | 94002 | 63337260 |
| Haematoma | 23.98 | 10.87 | 78 | 57682 | 34742 | 63396520 |
| Heparin-induced thrombocytopenia | 23.96 | 10.87 | 25 | 57735 | 4557 | 63426705 |
| Unresponsive to stimuli | 23.51 | 10.87 | 76 | 57684 | 33740 | 63397522 |
| Knee arthroplasty | 23.37 | 10.87 | 10 | 57750 | 54196 | 63377066 |
| Abortion spontaneous | 23.25 | 10.87 | 7 | 57753 | 47188 | 63384074 |
| Blood bicarbonate decreased | 22.91 | 10.87 | 20 | 57740 | 2921 | 63428341 |
| Emphysema | 22.88 | 10.87 | 38 | 57722 | 10900 | 63420362 |
| Influenza | 22.68 | 10.87 | 173 | 57587 | 108549 | 63322713 |
| Acute generalised exanthematous pustulosis | 22.47 | 10.87 | 38 | 57722 | 11061 | 63420201 |
| Amaurosis | 22.43 | 10.87 | 11 | 57749 | 598 | 63430664 |
| Lung disorder | 22.41 | 10.87 | 114 | 57646 | 62147 | 63369115 |
| Febrile neutropenia | 21.79 | 10.87 | 47 | 57713 | 118402 | 63312860 |
| Pulmonary function test decreased | 21.47 | 10.87 | 22 | 57738 | 3925 | 63427337 |
| Rectal prolapse | 20.73 | 10.87 | 16 | 57744 | 1967 | 63429295 |
| Oesophageal motility disorder | 20.52 | 10.87 | 9 | 57751 | 378 | 63430884 |
| Brain hypoxia | 20.52 | 10.87 | 10 | 57750 | 536 | 63430726 |
| Peripheral swelling | 20.31 | 10.87 | 150 | 57610 | 265792 | 63165470 |
| Optic ischaemic neuropathy | 20.08 | 10.87 | 13 | 57747 | 1209 | 63430053 |
| Eosinophil count abnormal | 19.82 | 10.87 | 10 | 57750 | 578 | 63430684 |
| Blood lactic acid increased | 19.57 | 10.87 | 28 | 57732 | 7058 | 63424204 |
| Adverse event | 19.02 | 10.87 | 20 | 57740 | 67539 | 63363723 |
| Peak expiratory flow rate abnormal | 18.94 | 10.87 | 6 | 57754 | 99 | 63431163 |
| Stress cardiomyopathy | 18.66 | 10.87 | 32 | 57728 | 9418 | 63421844 |
| Angina pectoris | 18.61 | 10.87 | 65 | 57695 | 30013 | 63401249 |
| Mobility decreased | 18.45 | 10.87 | 53 | 57707 | 121106 | 63310156 |
| Frustration tolerance decreased | 18.41 | 10.87 | 27 | 57733 | 6961 | 63424301 |
| Pupillary reflex impaired | 18.16 | 10.87 | 15 | 57745 | 2032 | 63429230 |
| Upper airway obstruction | 18.14 | 10.87 | 10 | 57750 | 693 | 63430569 |
| Hypoventilation | 18.11 | 10.87 | 22 | 57738 | 4732 | 63426530 |
| Upper respiratory tract irritation | 18.11 | 10.87 | 7 | 57753 | 212 | 63431050 |
| Injection site reaction | 18.02 | 10.87 | 16 | 57744 | 58508 | 63372754 |
| Premature delivery | 17.90 | 10.87 | 3 | 57757 | 30278 | 63400984 |
| Humidity intolerance | 17.85 | 10.87 | 8 | 57752 | 354 | 63430908 |
| Blood calcium increased | 17.60 | 10.87 | 31 | 57729 | 9319 | 63421943 |
| Sneezing | 17.54 | 10.87 | 46 | 57714 | 18172 | 63413090 |
| Dystrophic calcification | 17.50 | 10.87 | 6 | 57754 | 128 | 63431134 |
| Pulmonary oedema | 17.37 | 10.87 | 97 | 57663 | 54776 | 63376486 |
| Infusion site erythema | 17.36 | 10.87 | 35 | 57725 | 11644 | 63419618 |
| Seasonal allergy | 17.29 | 10.87 | 50 | 57710 | 20900 | 63410362 |
| Pneumonia staphylococcal | 17.21 | 10.87 | 17 | 57743 | 2903 | 63428359 |
| Musculoskeletal stiffness | 17.20 | 10.87 | 98 | 57662 | 184520 | 63246742 |
| Presyncope | 17.15 | 10.87 | 60 | 57700 | 27725 | 63403537 |
| Neuromyelitis optica spectrum disorder | 16.99 | 10.87 | 11 | 57749 | 1023 | 63430239 |
| Pneumonia respiratory syncytial viral | 16.84 | 10.87 | 11 | 57749 | 1039 | 63430223 |
| Pulmonary mass | 16.82 | 10.87 | 52 | 57708 | 22544 | 63408718 |
| Chest pain | 16.81 | 10.87 | 283 | 57477 | 215676 | 63215586 |
| Nephrocalcinosis | 16.57 | 10.87 | 11 | 57749 | 1067 | 63430195 |
| Staphylococcus test positive | 16.45 | 10.87 | 19 | 57741 | 3877 | 63427385 |
| Psoriasis | 16.42 | 10.87 | 34 | 57726 | 86923 | 63344339 |
| Infusion site extravasation | 16.40 | 10.87 | 32 | 57728 | 10394 | 63420868 |
| Disease progression | 16.37 | 10.87 | 57 | 57703 | 122701 | 63308561 |
| Oropharyngeal discomfort | 16.35 | 10.87 | 22 | 57738 | 5238 | 63426024 |
| Forced expiratory volume increased | 16.25 | 10.87 | 4 | 57756 | 24 | 63431238 |
| Chronic sinusitis | 16.20 | 10.87 | 36 | 57724 | 12807 | 63418455 |
| Injection site pain | 16.17 | 10.87 | 62 | 57698 | 129738 | 63301524 |
| Injection site bruising | 16.14 | 10.87 | 9 | 57751 | 41901 | 63389361 |
| Nausea | 15.57 | 10.87 | 628 | 57132 | 853843 | 62577419 |
| Tinnitus | 15.56 | 10.87 | 69 | 57691 | 35559 | 63395703 |
| Infusion site haemorrhage | 15.39 | 10.87 | 21 | 57739 | 5065 | 63426197 |
| Decreased appetite | 15.38 | 10.87 | 150 | 57610 | 250902 | 63180360 |
| Malaise | 15.15 | 10.87 | 490 | 57270 | 415464 | 63015798 |
| Pancytopenia | 15.05 | 10.87 | 42 | 57718 | 96891 | 63334371 |
| Abscess | 14.95 | 10.87 | 41 | 57719 | 16627 | 63414635 |
| Idiopathic angioedema | 14.64 | 10.87 | 4 | 57756 | 38 | 63431224 |
| Extensor plantar response | 14.63 | 10.87 | 11 | 57749 | 1300 | 63429962 |
| Acute myocardial infarction | 14.63 | 10.87 | 63 | 57697 | 32061 | 63399201 |
| Respiratory alkalosis | 14.59 | 10.87 | 15 | 57745 | 2686 | 63428576 |
| Glycosylated haemoglobin decreased | 14.46 | 10.87 | 8 | 57752 | 558 | 63430704 |
| Stomatitis | 14.39 | 10.87 | 71 | 57689 | 138654 | 63292608 |
| Hepatic function abnormal | 14.27 | 10.87 | 8 | 57752 | 37134 | 63394128 |
| Respiratory tract congestion | 14.18 | 10.87 | 42 | 57718 | 17790 | 63413472 |
| Sputum purulent | 14.13 | 10.87 | 10 | 57750 | 1077 | 63430185 |
| Inflammation | 14.03 | 10.87 | 34 | 57726 | 82239 | 63349023 |
| Infusion site pruritus | 14.03 | 10.87 | 22 | 57738 | 6013 | 63425249 |
| White blood cell count decreased | 13.97 | 10.87 | 72 | 57688 | 139032 | 63292230 |
| Eye pruritus | 13.93 | 10.87 | 43 | 57717 | 18628 | 63412634 |
| Hypoaesthesia | 13.81 | 10.87 | 93 | 57667 | 168300 | 63262962 |
| Vascular parkinsonism | 13.77 | 10.87 | 5 | 57755 | 127 | 63431135 |
| Lactic acidosis | 13.70 | 10.87 | 70 | 57690 | 38217 | 63393045 |
| Eczema | 13.70 | 10.87 | 62 | 57698 | 32229 | 63399033 |
| Peak expiratory flow rate decreased | 13.67 | 10.87 | 8 | 57752 | 621 | 63430641 |
| Hyperlipidaemia | 13.62 | 10.87 | 44 | 57716 | 19527 | 63411735 |
| Foetal exposure during pregnancy | 13.61 | 10.87 | 6 | 57754 | 31956 | 63399306 |
| Idiopathic intracranial hypertension | 13.58 | 10.87 | 15 | 57745 | 2916 | 63428346 |
| Agitation | 13.54 | 10.87 | 97 | 57663 | 59660 | 63371602 |
| Type 2 diabetes mellitus | 13.52 | 10.87 | 102 | 57658 | 63766 | 63367496 |
| Tremor | 13.27 | 10.87 | 181 | 57579 | 132058 | 63299204 |
| Chondrocalcinosis pyrophosphate | 13.26 | 10.87 | 10 | 57750 | 1188 | 63430074 |
| Laryngospasm | 13.18 | 10.87 | 15 | 57745 | 3013 | 63428249 |
| Pneumonia haemophilus | 13.15 | 10.87 | 8 | 57752 | 667 | 63430595 |
| Multiple sclerosis relapse | 12.93 | 10.87 | 15 | 57745 | 48463 | 63382799 |
| Hypersensitivity | 12.89 | 10.87 | 188 | 57572 | 292497 | 63138765 |
| Hypertrophic cardiomyopathy | 12.78 | 10.87 | 11 | 57749 | 1576 | 63429686 |
| Anxiety | 12.77 | 10.87 | 273 | 57487 | 217268 | 63213994 |
| Pharyngeal mass | 12.72 | 10.87 | 6 | 57754 | 299 | 63430963 |
| Sedation | 12.70 | 10.87 | 10 | 57750 | 38799 | 63392463 |
| Cardiomegaly | 12.62 | 10.87 | 40 | 57720 | 17574 | 63413688 |
| C-reactive protein increased | 12.61 | 10.87 | 44 | 57716 | 94663 | 63336599 |
| Flank pain | 12.44 | 10.87 | 38 | 57722 | 16372 | 63414890 |
| Inspiratory capacity decreased | 12.41 | 10.87 | 4 | 57756 | 70 | 63431192 |
| Ankle fracture | 12.30 | 10.87 | 40 | 57720 | 17815 | 63413447 |
| Hyperlactacidaemia | 12.21 | 10.87 | 14 | 57746 | 2835 | 63428427 |
| Musculoskeletal pain | 12.20 | 10.87 | 43 | 57717 | 92234 | 63339028 |
| Visceral pain | 12.19 | 10.87 | 3 | 57757 | 18 | 63431244 |
| Blood glucose abnormal | 12.15 | 10.87 | 24 | 57736 | 7868 | 63423394 |
| Frequent bowel movements | 12.12 | 10.87 | 3 | 57757 | 23019 | 63408243 |
| Anaphylactic reaction | 12.05 | 10.87 | 102 | 57658 | 65998 | 63365264 |
| Blood albumin decreased | 11.95 | 10.87 | 35 | 57725 | 14731 | 63416531 |
| Vocal cord disorder | 11.93 | 10.87 | 10 | 57750 | 1383 | 63429879 |
| Infusion site bruising | 11.87 | 10.87 | 16 | 57744 | 3816 | 63427446 |
| Forced expiratory volume abnormal | 11.82 | 10.87 | 4 | 57756 | 82 | 63431180 |
| Pneumonia pseudomonal | 11.80 | 10.87 | 13 | 57747 | 2520 | 63428742 |
| Bone marrow failure | 11.71 | 10.87 | 6 | 57754 | 29284 | 63401978 |
| Facial discomfort | 11.59 | 10.87 | 4 | 57756 | 87 | 63431175 |
| Tachycardia | 11.56 | 10.87 | 161 | 57599 | 117995 | 63313267 |
| Generalised tonic-clonic seizure | 11.51 | 10.87 | 6 | 57754 | 29010 | 63402252 |
| Impaired quality of life | 11.48 | 10.87 | 33 | 57727 | 13750 | 63417512 |
| Pulmonary pain | 11.47 | 10.87 | 15 | 57745 | 3475 | 63427787 |
| Restless legs syndrome | 11.42 | 10.87 | 40 | 57720 | 18491 | 63412771 |
| Pulmonary embolism | 11.42 | 10.87 | 159 | 57601 | 116525 | 63314737 |
| Angle closure glaucoma | 11.41 | 10.87 | 12 | 57748 | 2207 | 63429055 |
| Fluid retention | 11.35 | 10.87 | 93 | 57667 | 59593 | 63371669 |
| Foreign body sensation in eyes | 11.34 | 10.87 | 12 | 57748 | 2222 | 63429040 |
| Drug eruption | 11.29 | 10.87 | 6 | 57754 | 28688 | 63402574 |
| Breathing-related sleep disorder | 11.26 | 10.87 | 4 | 57756 | 95 | 63431167 |
| Cardiac disorder | 11.23 | 10.87 | 82 | 57678 | 50734 | 63380528 |
| Hiatus hernia | 11.13 | 10.87 | 44 | 57716 | 21550 | 63409712 |
| Barrett's oesophagus | 11.04 | 10.87 | 7 | 57753 | 628 | 63430634 |
| Tongue exfoliation | 11.00 | 10.87 | 4 | 57756 | 102 | 63431160 |
| Prescribed overdose | 10.92 | 10.87 | 9 | 57751 | 34144 | 63397118 |
| Tumour hyperprogression | 10.89 | 10.87 | 4 | 57756 | 105 | 63431157 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Asthma | 699.67 | 11.82 | 511 | 43180 | 42145 | 34871095 |
| Wheezing | 548.83 | 11.82 | 437 | 43254 | 40965 | 34872275 |
| Chronic obstructive pulmonary disease | 467.56 | 11.82 | 428 | 43263 | 48490 | 34864750 |
| Obstructive airways disorder | 453.62 | 11.82 | 267 | 43424 | 15227 | 34898013 |
| Dyspnoea | 330.60 | 11.82 | 1125 | 42566 | 375657 | 34537583 |
| Asthma-chronic obstructive pulmonary disease overlap syndrome | 269.88 | 11.82 | 89 | 43602 | 1198 | 34912042 |
| Appendicolith | 240.62 | 11.82 | 144 | 43547 | 8457 | 34904783 |
| Full blood count abnormal | 193.19 | 11.82 | 171 | 43520 | 18497 | 34894743 |
| Appendicitis | 182.58 | 11.82 | 150 | 43541 | 14657 | 34898583 |
| Stress | 174.09 | 11.82 | 202 | 43489 | 30145 | 34883095 |
| Sputum discoloured | 168.71 | 11.82 | 111 | 43580 | 7701 | 34905539 |
| Cardiogenic shock | 154.05 | 11.82 | 178 | 43513 | 26440 | 34886800 |
| Cough | 151.95 | 11.82 | 472 | 43219 | 149668 | 34763572 |
| Bronchiectasis | 135.09 | 11.82 | 106 | 43585 | 9695 | 34903545 |
| Nasal obstruction | 126.60 | 11.82 | 43 | 43648 | 637 | 34912603 |
| Chest discomfort | 125.60 | 11.82 | 236 | 43455 | 54294 | 34858946 |
| Productive cough | 123.25 | 11.82 | 191 | 43500 | 37622 | 34875618 |
| Pulmonary function test decreased | 120.52 | 11.82 | 76 | 43615 | 4899 | 34908341 |
| Sinus pain | 119.93 | 11.82 | 42 | 43649 | 685 | 34912555 |
| Pneumonia | 112.09 | 11.82 | 805 | 42886 | 361822 | 34551418 |
| Ventricular fibrillation | 110.75 | 11.82 | 140 | 43551 | 22814 | 34890426 |
| Fractional exhaled nitric oxide increased | 110.60 | 11.82 | 44 | 43647 | 1038 | 34912202 |
| Blood phosphorus increased | 101.03 | 11.82 | 81 | 43610 | 7640 | 34905600 |
| Forced expiratory volume decreased | 93.15 | 11.82 | 55 | 43636 | 3148 | 34910092 |
| Eosinophilia | 91.86 | 11.82 | 137 | 43554 | 26085 | 34887155 |
| Drug abuse | 86.37 | 11.82 | 11 | 43680 | 99085 | 34814155 |
| Toxicity to various agents | 85.35 | 11.82 | 75 | 43616 | 200287 | 34712953 |
| Toxic epidermal necrolysis | 84.42 | 11.82 | 119 | 43572 | 21527 | 34891713 |
| Completed suicide | 82.94 | 11.82 | 12 | 43679 | 98156 | 34815084 |
| Lower respiratory tract infection | 81.78 | 11.82 | 144 | 43547 | 31493 | 34881747 |
| Mycobacterium avium complex infection | 80.67 | 11.82 | 46 | 43645 | 2465 | 34910775 |
| Plantar fasciitis | 79.58 | 11.82 | 43 | 43648 | 2073 | 34911167 |
| Multiple organ dysfunction syndrome | 75.69 | 11.82 | 239 | 43452 | 76327 | 34836913 |
| Emphysema | 73.16 | 11.82 | 74 | 43617 | 9451 | 34903789 |
| Myoglobin blood increased | 72.77 | 11.82 | 46 | 43645 | 2977 | 34910263 |
| Nasal congestion | 71.67 | 11.82 | 114 | 43577 | 22943 | 34890297 |
| Sensation of foreign body | 71.15 | 11.82 | 44 | 43647 | 2739 | 34910501 |
| Dyspnoea exertional | 69.92 | 11.82 | 162 | 43529 | 43117 | 34870123 |
| Bronchitis | 69.92 | 11.82 | 159 | 43532 | 41804 | 34871436 |
| Middle insomnia | 69.72 | 11.82 | 62 | 43629 | 6740 | 34906500 |
| Abdominal distension | 69.59 | 11.82 | 195 | 43496 | 58297 | 34854943 |
| Therapeutic product effect incomplete | 68.69 | 11.82 | 177 | 43514 | 50364 | 34862876 |
| Ascites | 67.36 | 11.82 | 167 | 43524 | 46404 | 34866836 |
| Brain natriuretic peptide increased | 62.87 | 11.82 | 54 | 43637 | 5605 | 34907635 |
| Secretion discharge | 60.87 | 11.82 | 54 | 43637 | 5851 | 34907389 |
| Oxygen saturation decreased | 60.69 | 11.82 | 176 | 43515 | 53642 | 34859598 |
| Lung consolidation | 60.63 | 11.82 | 54 | 43637 | 5882 | 34907358 |
| Respiratory distress | 60.37 | 11.82 | 136 | 43555 | 35529 | 34877711 |
| General physical health deterioration | 59.03 | 11.82 | 316 | 43375 | 127953 | 34785287 |
| Osteopenia | 57.41 | 11.82 | 48 | 43643 | 4801 | 34908439 |
| Respiratory failure | 55.16 | 11.82 | 275 | 43416 | 108297 | 34804943 |
| Sleep disorder due to a general medical condition | 54.33 | 11.82 | 48 | 43643 | 5173 | 34908067 |
| Respiratory disorder | 54.12 | 11.82 | 91 | 43600 | 19173 | 34894067 |
| Hyponatraemia | 48.96 | 11.82 | 219 | 43472 | 82472 | 34830768 |
| Painful respiration | 48.96 | 11.82 | 26 | 43665 | 1210 | 34912030 |
| Pulmonary function test abnormal | 46.64 | 11.82 | 33 | 43658 | 2577 | 34910663 |
| Myasthenia gravis | 46.28 | 11.82 | 50 | 43641 | 6890 | 34906350 |
| Eye disorder | 44.18 | 11.82 | 57 | 43634 | 9471 | 34903769 |
| Dry mouth | 43.42 | 11.82 | 108 | 43583 | 30057 | 34883183 |
| Throat irritation | 42.46 | 11.82 | 59 | 43632 | 10526 | 34902714 |
| Bronchial hyperreactivity | 41.12 | 11.82 | 26 | 43665 | 1683 | 34911557 |
| Blood uric acid increased | 40.65 | 11.82 | 55 | 43636 | 9569 | 34903671 |
| Tachypnoea | 40.44 | 11.82 | 78 | 43613 | 18274 | 34894966 |
| Chest injury | 40.28 | 11.82 | 25 | 43666 | 1566 | 34911674 |
| Diarrhoea | 39.78 | 11.82 | 305 | 43386 | 389607 | 34523633 |
| Pneumothorax | 39.47 | 11.82 | 79 | 43612 | 19013 | 34894227 |
| Pulmonary mass | 37.97 | 11.82 | 62 | 43629 | 12750 | 34900490 |
| Pleural thickening | 37.08 | 11.82 | 15 | 43676 | 370 | 34912870 |
| Bronchospasm | 36.05 | 11.82 | 55 | 43636 | 10676 | 34902564 |
| Pneumonitis | 34.58 | 11.82 | 107 | 43584 | 33771 | 34879469 |
| Exostosis | 33.21 | 11.82 | 35 | 43656 | 4688 | 34908552 |
| Constipation | 33.15 | 11.82 | 288 | 43403 | 136694 | 34776546 |
| Dysphonia | 31.86 | 11.82 | 82 | 43609 | 23301 | 34889939 |
| Drug therapy | 31.63 | 11.82 | 19 | 43672 | 1122 | 34912118 |
| Genital herpes simplex | 31.44 | 11.82 | 10 | 43681 | 119 | 34913121 |
| Foetal exposure during pregnancy | 31.37 | 11.82 | 5 | 43686 | 38096 | 34875144 |
| Walking aid user | 31.35 | 11.82 | 23 | 43668 | 1901 | 34911339 |
| Analgesic therapy | 31.30 | 11.82 | 18 | 43673 | 980 | 34912260 |
| Hypoventilation | 30.85 | 11.82 | 29 | 43662 | 3385 | 34909855 |
| Overdose | 30.00 | 11.82 | 42 | 43649 | 91017 | 34822223 |
| Diaphragmatic disorder | 29.69 | 11.82 | 19 | 43672 | 1256 | 34911984 |
| Hyperkaliuria | 29.27 | 11.82 | 9 | 43682 | 95 | 34913145 |
| Lung disorder | 27.80 | 11.82 | 101 | 43590 | 34595 | 34878645 |
| Sensitivity to weather change | 27.77 | 11.82 | 20 | 43671 | 1606 | 34911634 |
| Febrile neutropenia | 25.99 | 11.82 | 86 | 43605 | 136763 | 34776477 |
| White blood cell count decreased | 25.87 | 11.82 | 50 | 43641 | 95395 | 34817845 |
| Neuropathy peripheral | 25.87 | 11.82 | 40 | 43651 | 83223 | 34830017 |
| Malignant neoplasm progression | 25.76 | 11.82 | 44 | 43647 | 88002 | 34825238 |
| Use of accessory respiratory muscles | 25.76 | 11.82 | 12 | 43679 | 420 | 34912820 |
| Sleep disorder therapy | 25.71 | 11.82 | 16 | 43675 | 1007 | 34912233 |
| Total lung capacity abnormal | 25.52 | 11.82 | 9 | 43682 | 150 | 34913090 |
| Hypercapnia | 25.51 | 11.82 | 29 | 43662 | 4226 | 34909014 |
| Seasonal allergy | 24.99 | 11.82 | 36 | 43655 | 6639 | 34906601 |
| Hyperphosphataemia | 24.53 | 11.82 | 29 | 43662 | 4408 | 34908832 |
| Bronchitis viral | 24.37 | 11.82 | 10 | 43681 | 256 | 34912984 |
| Upper-airway cough syndrome | 24.37 | 11.82 | 26 | 43665 | 3532 | 34909708 |
| COVID-19 treatment | 23.95 | 11.82 | 10 | 43681 | 268 | 34912972 |
| Oral candidiasis | 23.71 | 11.82 | 49 | 43642 | 12061 | 34901179 |
| Ocular discomfort | 22.97 | 11.82 | 20 | 43671 | 2114 | 34911126 |
| Platelet count decreased | 22.89 | 11.82 | 75 | 43616 | 119642 | 34793598 |
| Breath sounds abnormal | 22.73 | 11.82 | 35 | 43656 | 6846 | 34906394 |
| Wolff-Parkinson-White syndrome | 22.44 | 11.82 | 9 | 43682 | 217 | 34913023 |
| Lung hyperinflation | 22.43 | 11.82 | 14 | 43677 | 886 | 34912354 |
| Iron deficiency | 21.59 | 11.82 | 30 | 43661 | 5351 | 34907889 |
| Off label use | 21.59 | 11.82 | 382 | 43309 | 419142 | 34494098 |
| Intentional overdose | 21.56 | 11.82 | 14 | 43677 | 43660 | 34869580 |
| Bronchial wall thickening | 21.49 | 11.82 | 16 | 43675 | 1352 | 34911888 |
| Drug ineffective | 21.31 | 11.82 | 423 | 43268 | 456328 | 34456912 |
| Hypoxia | 20.88 | 11.82 | 129 | 43562 | 54966 | 34858274 |
| Chronic respiratory failure | 20.87 | 11.82 | 16 | 43675 | 1413 | 34911827 |
| Influenza | 20.56 | 11.82 | 119 | 43572 | 49547 | 34863693 |
| Treatment failure | 20.42 | 11.82 | 17 | 43674 | 46680 | 34866560 |
| Blood immunoglobulin E decreased | 20.37 | 11.82 | 6 | 43685 | 54 | 34913186 |
| Aortic aneurysm | 20.35 | 11.82 | 33 | 43658 | 6746 | 34906494 |
| Type IIa hyperlipidaemia | 20.06 | 11.82 | 8 | 43683 | 190 | 34913050 |
| Blood immunoglobulin E increased | 19.95 | 11.82 | 20 | 43671 | 2526 | 34910714 |
| Dust allergy | 19.86 | 11.82 | 13 | 43678 | 893 | 34912347 |
| Rash | 19.58 | 11.82 | 181 | 43510 | 222571 | 34690669 |
| Inappropriate schedule of product administration | 19.28 | 11.82 | 30 | 43661 | 62266 | 34850974 |
| Hypohidrosis | 19.24 | 11.82 | 8 | 43683 | 212 | 34913028 |
| Neutropenia | 19.21 | 11.82 | 116 | 43575 | 156662 | 34756578 |
| Forced vital capacity decreased | 19.16 | 11.82 | 12 | 43679 | 764 | 34912476 |
| Incorrect route of product administration | 19.13 | 11.82 | 51 | 43640 | 14794 | 34898446 |
| Peak expiratory flow rate decreased | 19.05 | 11.82 | 7 | 43684 | 132 | 34913108 |
| Illness | 19.00 | 11.82 | 48 | 43643 | 13481 | 34899759 |
| Respiratory tract infection | 18.96 | 11.82 | 61 | 43630 | 19651 | 34893589 |
| Infective pulmonary exacerbation of cystic fibrosis | 18.93 | 11.82 | 32 | 43659 | 6769 | 34906471 |
| Tachycardia foetal | 18.83 | 11.82 | 9 | 43682 | 334 | 34912906 |
| Genital herpes | 18.71 | 11.82 | 11 | 43680 | 624 | 34912616 |
| Respiratory tract congestion | 18.58 | 11.82 | 30 | 43661 | 6109 | 34907131 |
| Respiratory acidosis | 18.56 | 11.82 | 27 | 43664 | 5023 | 34908217 |
| Aggression | 18.55 | 11.82 | 13 | 43678 | 38951 | 34874289 |
| Feeling cold | 18.47 | 11.82 | 41 | 43650 | 10598 | 34902642 |
| Disease progression | 18.46 | 11.82 | 71 | 43620 | 108006 | 34805234 |
| Rales | 18.20 | 11.82 | 39 | 43652 | 9844 | 34903396 |
| Atrial fibrillation | 18.09 | 11.82 | 233 | 43458 | 122160 | 34791080 |
| Drug resistance | 18.07 | 11.82 | 5 | 43686 | 25922 | 34887318 |
| Cardiac disorder | 17.63 | 11.82 | 103 | 43588 | 43023 | 34870217 |
| Blood cholesterol increased | 17.48 | 11.82 | 61 | 43630 | 20482 | 34892758 |
| Suicide attempt | 17.40 | 11.82 | 14 | 43677 | 39102 | 34874138 |
| Bilirubin conjugated abnormal | 16.69 | 11.82 | 6 | 43685 | 106 | 34913134 |
| Perfume sensitivity | 16.59 | 11.82 | 6 | 43685 | 108 | 34913132 |
| Haemoptysis | 16.57 | 11.82 | 87 | 43604 | 34919 | 34878321 |
| Sneezing | 16.39 | 11.82 | 26 | 43665 | 5216 | 34908024 |
| Diastolic hypotension | 16.33 | 11.82 | 5 | 43686 | 52 | 34913188 |
| Left ventricular hypertrophy | 16.04 | 11.82 | 33 | 43658 | 8097 | 34905143 |
| Bronchospasm paradoxical | 15.91 | 11.82 | 5 | 43686 | 57 | 34913183 |
| Reversible airways obstruction | 15.82 | 11.82 | 9 | 43682 | 480 | 34912760 |
| Sepsis | 15.75 | 11.82 | 294 | 43397 | 166267 | 34746973 |
| Injection related reaction | 15.60 | 11.82 | 8 | 43683 | 346 | 34912894 |
| Multiple allergies | 15.57 | 11.82 | 19 | 43672 | 2984 | 34910256 |
| Carbon dioxide increased | 15.56 | 11.82 | 12 | 43679 | 1069 | 34912171 |
| Back injury | 15.43 | 11.82 | 22 | 43669 | 4019 | 34909221 |
| Pancreatitis acute | 15.33 | 11.82 | 8 | 43683 | 28133 | 34885107 |
| Viral myelitis | 15.32 | 11.82 | 5 | 43686 | 65 | 34913175 |
| Headache | 15.15 | 11.82 | 169 | 43522 | 200466 | 34712774 |
| Ischaemic cardiomyopathy | 15.12 | 11.82 | 28 | 43663 | 6361 | 34906879 |
| Vital capacity decreased | 14.83 | 11.82 | 8 | 43683 | 384 | 34912856 |
| Conjunctivitis allergic | 14.72 | 11.82 | 12 | 43679 | 1158 | 34912082 |
| Product prescribing error | 14.52 | 11.82 | 62 | 43629 | 22865 | 34890375 |
| Occupational exposure to air contaminants | 14.47 | 11.82 | 6 | 43685 | 158 | 34913082 |
| Pruritus | 14.43 | 11.82 | 111 | 43580 | 141870 | 34771370 |
| Memory impairment | 14.24 | 11.82 | 20 | 43671 | 43298 | 34869942 |
| Fatigue | 13.91 | 11.82 | 355 | 43336 | 370298 | 34542942 |
| Respiratory rate increased | 13.79 | 11.82 | 35 | 43656 | 9859 | 34903381 |
| Psoriasis | 13.70 | 11.82 | 17 | 43674 | 38795 | 34874445 |
| Toxic optic neuropathy | 13.48 | 11.82 | 10 | 43681 | 840 | 34912400 |
| Cytomegalovirus infection | 13.42 | 11.82 | 8 | 43683 | 26127 | 34887113 |
| Acute respiratory failure | 13.38 | 11.82 | 75 | 43616 | 30853 | 34882387 |
| Pain | 13.33 | 11.82 | 178 | 43513 | 204497 | 34708743 |
| Premature baby | 13.29 | 11.82 | 4 | 43687 | 19629 | 34893611 |
| Cytokine release syndrome | 13.23 | 11.82 | 6 | 43685 | 22871 | 34890369 |
| Bone marrow oedema | 13.19 | 11.82 | 9 | 43682 | 663 | 34912577 |
| Status asthmaticus | 13.14 | 11.82 | 7 | 43684 | 328 | 34912912 |
| Subcutaneous emphysema | 12.47 | 11.82 | 11 | 43680 | 1183 | 34912057 |
| Medication error | 12.42 | 11.82 | 64 | 43627 | 25501 | 34887739 |
| Therapeutic response decreased | 12.41 | 11.82 | 11 | 43680 | 29302 | 34883938 |
| Lung opacity | 12.35 | 11.82 | 15 | 43676 | 2344 | 34910896 |
| Mycobacterial infection | 12.28 | 11.82 | 15 | 43676 | 2359 | 34910881 |
| Hyperaesthesia teeth | 12.16 | 11.82 | 8 | 43683 | 554 | 34912686 |
| Expiratory reserve volume decreased | 12.05 | 11.82 | 4 | 43687 | 55 | 34913185 |
| Cardiomyopathy | 11.86 | 11.82 | 47 | 43644 | 16761 | 34896479 |
| Gastrointestinal disorder | 11.84 | 11.82 | 15 | 43676 | 33933 | 34879307 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Asthma | 1620.56 | 10.55 | 1263 | 84523 | 133832 | 79524770 |
| Wheezing | 1072.03 | 10.55 | 935 | 84851 | 115729 | 79542873 |
| Obstructive airways disorder | 870.78 | 10.55 | 496 | 85290 | 30963 | 79627639 |
| Chronic obstructive pulmonary disease | 846.12 | 10.55 | 715 | 85071 | 84704 | 79573898 |
| Dyspnoea | 599.62 | 10.55 | 2148 | 83638 | 854877 | 78803725 |
| Full blood count abnormal | 376.33 | 10.55 | 327 | 85459 | 40147 | 79618455 |
| Asthma-chronic obstructive pulmonary disease overlap syndrome | 352.05 | 10.55 | 132 | 85654 | 3089 | 79655513 |
| Productive cough | 348.69 | 10.55 | 452 | 85334 | 87879 | 79570723 |
| Cough | 336.09 | 10.55 | 1010 | 84776 | 365779 | 79292823 |
| Pneumonia | 322.54 | 10.55 | 1483 | 84303 | 658763 | 78999839 |
| Chest discomfort | 258.67 | 10.55 | 502 | 85284 | 137542 | 79521060 |
| Appendicolith | 258.66 | 10.55 | 143 | 85643 | 8408 | 79650194 |
| Sputum discoloured | 248.49 | 10.55 | 198 | 85588 | 21545 | 79637057 |
| Bronchiectasis | 237.10 | 10.55 | 195 | 85591 | 22191 | 79636411 |
| Completed suicide | 225.35 | 10.55 | 9 | 85777 | 245758 | 79412844 |
| Sleep disorder due to a general medical condition | 209.59 | 10.55 | 151 | 85635 | 14126 | 79644476 |
| Middle insomnia | 193.66 | 10.55 | 151 | 85635 | 15918 | 79642684 |
| Toxicity to various agents | 169.33 | 10.55 | 124 | 85662 | 421416 | 79237186 |
| Nasal congestion | 166.59 | 10.55 | 297 | 85489 | 76255 | 79582347 |
| Appendicitis | 163.65 | 10.55 | 153 | 85633 | 20641 | 79637961 |
| Forced expiratory volume decreased | 141.40 | 10.55 | 94 | 85692 | 7720 | 79650882 |
| Synovitis | 130.22 | 10.55 | 8 | 85778 | 150726 | 79507876 |
| Dyspnoea exertional | 128.24 | 10.55 | 287 | 85499 | 86786 | 79571816 |
| Respiratory failure | 124.73 | 10.55 | 453 | 85333 | 180458 | 79478144 |
| Lower respiratory tract infection | 121.86 | 10.55 | 360 | 85426 | 128860 | 79529742 |
| Nasal obstruction | 121.27 | 10.55 | 55 | 85731 | 2109 | 79656493 |
| Bronchitis | 120.38 | 10.55 | 361 | 85425 | 130283 | 79528319 |
| Stress | 120.16 | 10.55 | 265 | 85521 | 79347 | 79579255 |
| Cardiogenic shock | 118.55 | 10.55 | 183 | 85603 | 41731 | 79616871 |
| Drug abuse | 116.22 | 10.55 | 18 | 85768 | 162673 | 79495929 |
| Pulmonary function test decreased | 114.90 | 10.55 | 82 | 85704 | 7555 | 79651047 |
| Breath sounds abnormal | 113.25 | 10.55 | 111 | 85675 | 15873 | 79642729 |
| Therapeutic product effect incomplete | 112.68 | 10.55 | 372 | 85414 | 141273 | 79517329 |
| Total lung capacity increased | 111.94 | 10.55 | 53 | 85733 | 2245 | 79656357 |
| Alopecia | 108.08 | 10.55 | 57 | 85729 | 231298 | 79427304 |
| Eosinophilia | 107.84 | 10.55 | 183 | 85603 | 45162 | 79613440 |
| Toxic epidermal necrolysis | 104.81 | 10.55 | 179 | 85607 | 44402 | 79614200 |
| Drug intolerance | 104.26 | 10.55 | 79 | 85707 | 264040 | 79394562 |
| Systemic lupus erythematosus | 100.09 | 10.55 | 8 | 85778 | 121141 | 79537461 |
| Nasal polyps | 99.63 | 10.55 | 74 | 85712 | 7253 | 79651349 |
| Treatment failure | 97.43 | 10.55 | 31 | 85755 | 170455 | 79488147 |
| Oxygen saturation decreased | 97.40 | 10.55 | 333 | 85453 | 128714 | 79529888 |
| Ventricular fibrillation | 96.82 | 10.55 | 144 | 85642 | 31782 | 79626820 |
| Upper-airway cough syndrome | 95.80 | 10.55 | 88 | 85698 | 11605 | 79646997 |
| Hand deformity | 94.54 | 10.55 | 4 | 85782 | 103915 | 79554687 |
| Infusion related reaction | 93.27 | 10.55 | 67 | 85719 | 230170 | 79428432 |
| Nasal turbinate hypertrophy | 91.82 | 10.55 | 33 | 85753 | 682 | 79657920 |
| Respiratory distress | 91.21 | 10.55 | 197 | 85589 | 58142 | 79600460 |
| Blood phosphorus increased | 90.92 | 10.55 | 81 | 85705 | 10266 | 79648336 |
| Arthropathy | 89.80 | 10.55 | 39 | 85747 | 177072 | 79481530 |
| Rales | 89.42 | 10.55 | 109 | 85677 | 19892 | 79638710 |
| Blood immunoglobulin E increased | 88.13 | 10.55 | 63 | 85723 | 5819 | 79652783 |
| Drug ineffective | 88.06 | 10.55 | 743 | 85043 | 1080170 | 78578432 |
| Cardiac murmur | 87.12 | 10.55 | 96 | 85690 | 15728 | 79642874 |
| Bronchial neoplasm | 86.73 | 10.55 | 29 | 85757 | 479 | 79658123 |
| Rheumatoid arthritis | 86.64 | 10.55 | 59 | 85727 | 208411 | 79450191 |
| Pericarditis | 85.78 | 10.55 | 7 | 85779 | 104229 | 79554373 |
| Off label use | 85.38 | 10.55 | 599 | 85187 | 906616 | 78751986 |
| Bronchospasm | 82.47 | 10.55 | 117 | 85669 | 24742 | 79633860 |
| Glossodynia | 82.18 | 10.55 | 8 | 85778 | 103329 | 79555273 |
| Sleep apnoea syndrome | 81.22 | 10.55 | 143 | 85643 | 36335 | 79622267 |
| Joint swelling | 80.52 | 10.55 | 116 | 85670 | 288530 | 79370072 |
| Blood test abnormal | 79.96 | 10.55 | 97 | 85689 | 17613 | 79640989 |
| Hypercapnia | 78.62 | 10.55 | 70 | 85716 | 8865 | 79649737 |
| Pemphigus | 78.43 | 10.55 | 8 | 85778 | 99574 | 79559028 |
| Gastrooesophageal reflux disease | 77.77 | 10.55 | 268 | 85518 | 103978 | 79554624 |
| Vocal cord dysfunction | 77.54 | 10.55 | 28 | 85758 | 587 | 79658015 |
| Tachypnoea | 77.03 | 10.55 | 130 | 85656 | 31933 | 79626669 |
| Respiratory disorder | 76.55 | 10.55 | 157 | 85629 | 44699 | 79613903 |
| Acute respiratory failure | 76.42 | 10.55 | 186 | 85600 | 59355 | 79599247 |
| Hypoxia | 75.78 | 10.55 | 264 | 85522 | 102979 | 79555623 |
| Hyper IgE syndrome | 75.76 | 10.55 | 27 | 85759 | 544 | 79658058 |
| Haemoptysis | 74.09 | 10.55 | 177 | 85609 | 55822 | 79602780 |
| Oesophageal spasm | 73.44 | 10.55 | 46 | 85740 | 3410 | 79655192 |
| Total lung capacity decreased | 72.87 | 10.55 | 43 | 85743 | 2862 | 79655740 |
| Therapeutic product effect decreased | 72.71 | 10.55 | 43 | 85743 | 163820 | 79494782 |
| Contraindicated product administered | 71.82 | 10.55 | 40 | 85746 | 157498 | 79501104 |
| Rhonchi | 71.69 | 10.55 | 48 | 85738 | 3988 | 79654614 |
| Arthralgia | 71.05 | 10.55 | 345 | 85441 | 571458 | 79087144 |
| Pain | 70.96 | 10.55 | 455 | 85331 | 703347 | 78955255 |
| Endometrial ablation | 70.78 | 10.55 | 29 | 85757 | 864 | 79657738 |
| Respiration abnormal | 70.49 | 10.55 | 62 | 85724 | 7726 | 79650876 |
| Ventricular failure | 69.41 | 10.55 | 25 | 85761 | 520 | 79658082 |
| Restrictive pulmonary disease | 69.29 | 10.55 | 40 | 85746 | 2555 | 79656047 |
| Multiple organ dysfunction syndrome | 68.05 | 10.55 | 283 | 85503 | 119963 | 79538639 |
| Bronchopulmonary aspergillosis allergic | 63.19 | 10.55 | 40 | 85746 | 3021 | 79655581 |
| Bronchial haemorrhage | 62.94 | 10.55 | 30 | 85756 | 1290 | 79657312 |
| Rash | 61.83 | 10.55 | 367 | 85419 | 577991 | 79080611 |
| Emphysema | 60.51 | 10.55 | 81 | 85705 | 16219 | 79642383 |
| Rhinitis allergic | 60.01 | 10.55 | 70 | 85716 | 12199 | 79646403 |
| Upper respiratory tract infection | 59.17 | 10.55 | 224 | 85562 | 90944 | 79567658 |
| Heart sounds | 58.75 | 10.55 | 26 | 85760 | 940 | 79657662 |
| Prolonged expiration | 57.91 | 10.55 | 28 | 85758 | 1243 | 79657359 |
| Oesophageal pain | 57.69 | 10.55 | 43 | 85743 | 4236 | 79654366 |
| Diarrhoea | 57.64 | 10.55 | 638 | 85148 | 879851 | 78778751 |
| Lung hyperinflation | 55.97 | 10.55 | 31 | 85755 | 1828 | 79656774 |
| Rib deformity | 54.87 | 10.55 | 17 | 85769 | 217 | 79658385 |
| Helicobacter infection | 53.86 | 10.55 | 6 | 85780 | 69698 | 79588904 |
| Breast conserving surgery | 53.71 | 10.55 | 23 | 85763 | 767 | 79657835 |
| Duodenal ulcer perforation | 52.97 | 10.55 | 5 | 85781 | 66206 | 79592396 |
| Mycobacterium avium complex infection | 52.78 | 10.55 | 42 | 85744 | 4558 | 79654044 |
| Laryngeal stenosis | 52.71 | 10.55 | 25 | 85761 | 1063 | 79657539 |
| Pulmonary function test abnormal | 52.23 | 10.55 | 40 | 85746 | 4104 | 79654498 |
| Wound | 52.23 | 10.55 | 30 | 85756 | 116149 | 79542453 |
| Abdominal discomfort | 51.86 | 10.55 | 121 | 85665 | 250606 | 79407996 |
| Maternal exposure during pregnancy | 51.12 | 10.55 | 43 | 85743 | 136495 | 79522107 |
| Respiratory rate increased | 51.12 | 10.55 | 87 | 85699 | 21513 | 79637089 |
| Lung opacity | 50.49 | 10.55 | 43 | 85743 | 5131 | 79653471 |
| Sarcoidosis | 50.15 | 10.55 | 53 | 85733 | 8282 | 79650320 |
| Bronchial disorder | 50.07 | 10.55 | 32 | 85754 | 2457 | 79656145 |
| Blister | 49.37 | 10.55 | 34 | 85752 | 119442 | 79539160 |
| Rhinitis | 48.10 | 10.55 | 69 | 85717 | 14738 | 79643864 |
| Product use issue | 46.89 | 10.55 | 97 | 85689 | 209725 | 79448877 |
| Ascites | 46.04 | 10.55 | 182 | 85604 | 75380 | 79583222 |
| Hypoventilation | 45.37 | 10.55 | 47 | 85739 | 7177 | 79651425 |
| Loss of personal independence in daily activities | 45.01 | 10.55 | 224 | 85562 | 102356 | 79556246 |
| Pneumonitis | 44.10 | 10.55 | 155 | 85631 | 60705 | 79597897 |
| Intentional overdose | 43.98 | 10.55 | 30 | 85756 | 105930 | 79552672 |
| Throat clearing | 43.42 | 10.55 | 30 | 85756 | 2624 | 79655978 |
| Influenza | 42.79 | 10.55 | 262 | 85524 | 129344 | 79529258 |
| Sinus pain | 42.58 | 10.55 | 34 | 85752 | 3708 | 79654894 |
| Lung consolidation | 42.02 | 10.55 | 50 | 85736 | 8897 | 79649705 |
| Status asthmaticus | 41.81 | 10.55 | 21 | 85765 | 1013 | 79657589 |
| Reversible airways obstruction | 41.37 | 10.55 | 27 | 85759 | 2149 | 79656453 |
| Febrile neutropenia | 41.24 | 10.55 | 120 | 85666 | 230879 | 79427723 |
| Myasthenia gravis | 40.64 | 10.55 | 53 | 85733 | 10346 | 79648256 |
| Respiratory tract infection | 40.59 | 10.55 | 130 | 85656 | 48559 | 79610043 |
| Infective pulmonary exacerbation of cystic fibrosis | 40.45 | 10.55 | 59 | 85727 | 12792 | 79645810 |
| PCO2 increased | 40.39 | 10.55 | 25 | 85761 | 1815 | 79656787 |
| Hepatic enzyme increased | 40.31 | 10.55 | 85 | 85701 | 182525 | 79476077 |
| Bronchial hyperreactivity | 39.76 | 10.55 | 30 | 85756 | 3010 | 79655592 |
| Respiratory acidosis | 39.06 | 10.55 | 54 | 85732 | 11146 | 79647456 |
| Psoriatic arthropathy | 38.23 | 10.55 | 18 | 85768 | 77981 | 79580621 |
| Hyponatraemia | 38.10 | 10.55 | 324 | 85462 | 177524 | 79481078 |
| Muscle injury | 37.98 | 10.55 | 4 | 85782 | 48557 | 79610045 |
| Abdominal distension | 37.69 | 10.55 | 239 | 85547 | 119411 | 79539191 |
| Sinus disorder | 37.58 | 10.55 | 78 | 85708 | 22386 | 79636216 |
| Seasonal allergy | 37.40 | 10.55 | 65 | 85721 | 16341 | 79642261 |
| Lung neoplasm malignant | 36.92 | 10.55 | 88 | 85698 | 27704 | 79630898 |
| Lung disorder | 36.83 | 10.55 | 178 | 85608 | 80379 | 79578223 |
| Oedema peripheral | 36.70 | 10.55 | 424 | 85362 | 251864 | 79406738 |
| COVID-19 treatment | 36.36 | 10.55 | 15 | 85771 | 455 | 79658147 |
| Dysphonia | 36.29 | 10.55 | 139 | 85647 | 56733 | 79601869 |
| Sight disability | 36.12 | 10.55 | 11 | 85775 | 132 | 79658470 |
| Irritable bowel syndrome | 36.11 | 10.55 | 11 | 85775 | 62230 | 79596372 |
| PO2 decreased | 36.03 | 10.55 | 28 | 85758 | 2935 | 79655667 |
| Pulmonary mass | 35.45 | 10.55 | 89 | 85697 | 28945 | 79629657 |
| Red blood cell sedimentation rate increased | 35.38 | 10.55 | 4 | 85782 | 45938 | 79612664 |
| Neuropathy peripheral | 35.36 | 10.55 | 61 | 85725 | 141244 | 79517358 |
| Overdose | 34.87 | 10.55 | 93 | 85693 | 184113 | 79474489 |
| Impaired healing | 34.83 | 10.55 | 26 | 85760 | 87629 | 79570973 |
| Blood uric acid increased | 34.55 | 10.55 | 56 | 85730 | 13304 | 79645298 |
| Painful respiration | 34.31 | 10.55 | 29 | 85757 | 3424 | 79655178 |
| Intentional product use issue | 34.25 | 10.55 | 70 | 85716 | 152042 | 79506560 |
| Exposure during pregnancy | 34.13 | 10.55 | 35 | 85751 | 101097 | 79557505 |
| Polycystic ovaries | 34.03 | 10.55 | 30 | 85756 | 3749 | 79654853 |
| Diaphragmatic disorder | 33.97 | 10.55 | 22 | 85764 | 1728 | 79656874 |
| Aspiration | 33.73 | 10.55 | 70 | 85716 | 20088 | 79638514 |
| Analgesic therapy | 33.64 | 10.55 | 18 | 85768 | 991 | 79657611 |
| Thermohypoaesthesia | 33.47 | 10.55 | 10 | 85776 | 112 | 79658490 |
| Drug therapy | 33.37 | 10.55 | 19 | 85767 | 1182 | 79657420 |
| Chest injury | 32.89 | 10.55 | 26 | 85760 | 2795 | 79655807 |
| Drug-induced liver injury | 32.80 | 10.55 | 15 | 85771 | 66102 | 79592500 |
| Influenza B virus test positive | 32.32 | 10.55 | 13 | 85773 | 369 | 79658233 |
| Sinus tachycardia | 31.18 | 10.55 | 99 | 85687 | 36809 | 79621793 |
| Peak expiratory flow rate decreased | 30.98 | 10.55 | 15 | 85771 | 668 | 79657934 |
| Fatigue | 30.71 | 10.55 | 764 | 85022 | 928963 | 78729639 |
| Lymphoedema | 30.70 | 10.55 | 51 | 85735 | 12362 | 79646240 |
| Cyanosis | 30.54 | 10.55 | 77 | 85709 | 25105 | 79633497 |
| Airway peak pressure increased | 30.05 | 10.55 | 12 | 85774 | 334 | 79658268 |
| Discomfort | 29.84 | 10.55 | 56 | 85730 | 125561 | 79533041 |
| Sneezing | 29.09 | 10.55 | 65 | 85721 | 19618 | 79638984 |
| Swelling | 29.06 | 10.55 | 127 | 85659 | 216584 | 79442018 |
| Hyperphosphataemia | 28.91 | 10.55 | 35 | 85751 | 6341 | 79652261 |
| Hypomania | 28.79 | 10.55 | 38 | 85748 | 7506 | 79651096 |
| White blood cell count decreased | 27.97 | 10.55 | 106 | 85680 | 188182 | 79470420 |
| Sleep disorder therapy | 27.92 | 10.55 | 16 | 85770 | 1008 | 79657594 |
| Respiratory gas exchange disorder | 27.86 | 10.55 | 15 | 85771 | 836 | 79657766 |
| Hip arthroplasty | 27.82 | 10.55 | 3 | 85783 | 35753 | 79622849 |
| Kyphosis | 27.57 | 10.55 | 23 | 85763 | 2668 | 79655934 |
| Heart rate increased | 27.48 | 10.55 | 223 | 85563 | 120501 | 79538101 |
| Frustration tolerance decreased | 27.42 | 10.55 | 37 | 85749 | 7465 | 79651137 |
| Drug resistance | 27.28 | 10.55 | 6 | 85780 | 42207 | 79616395 |
| Cardiac failure congestive | 27.18 | 10.55 | 253 | 85533 | 142149 | 79516453 |
| Aortic aneurysm | 26.91 | 10.55 | 39 | 85747 | 8407 | 79650195 |
| Gastrointestinal disorder | 26.86 | 10.55 | 57 | 85729 | 122148 | 79536454 |
| Disease progression | 26.60 | 10.55 | 105 | 85681 | 184257 | 79474345 |
| Venous pressure jugular increased | 26.39 | 10.55 | 17 | 85769 | 1323 | 79657279 |
| Atrial fibrillation | 26.32 | 10.55 | 327 | 85459 | 197559 | 79461043 |
| Platelet count decreased | 26.14 | 10.55 | 114 | 85672 | 194550 | 79464052 |
| Hyperkaliuria | 25.84 | 10.55 | 9 | 85777 | 169 | 79658433 |
| Liver disorder | 25.66 | 10.55 | 24 | 85762 | 72393 | 79586209 |
| C-reactive protein abnormal | 25.55 | 10.55 | 10 | 85776 | 48357 | 79610245 |
| Pulmonary hypertension | 25.51 | 10.55 | 111 | 85675 | 47969 | 79610633 |
| Chronic respiratory failure | 25.25 | 10.55 | 23 | 85763 | 2999 | 79655603 |
| General physical health deterioration | 25.16 | 10.55 | 426 | 85360 | 274812 | 79383790 |
| Constipation | 24.76 | 10.55 | 435 | 85351 | 282615 | 79375987 |
| Wolff-Parkinson-White syndrome | 24.56 | 10.55 | 10 | 85776 | 293 | 79658309 |
| Pneumonia viral | 24.52 | 10.55 | 39 | 85747 | 9119 | 79649483 |
| Asthmatic crisis | 24.49 | 10.55 | 19 | 85767 | 1987 | 79656615 |
| Separation anxiety disorder | 24.30 | 10.55 | 6 | 85780 | 30 | 79658572 |
| Lactose intolerance | 24.05 | 10.55 | 20 | 85766 | 2310 | 79656292 |
| Psoriasis | 23.97 | 10.55 | 37 | 85749 | 89550 | 79569052 |
| Sensitivity to weather change | 23.97 | 10.55 | 36 | 85750 | 8011 | 79650591 |
| Multiple sclerosis relapse | 23.96 | 10.55 | 10 | 85776 | 46523 | 79612079 |
| Headache | 23.54 | 10.55 | 530 | 85256 | 653242 | 79005360 |
| Jaundice cholestatic | 23.53 | 10.55 | 43 | 85743 | 11241 | 79647361 |
| FEV1/FVC ratio decreased | 23.52 | 10.55 | 9 | 85777 | 223 | 79658379 |
| Suicide attempt | 23.41 | 10.55 | 33 | 85753 | 82899 | 79575703 |
| Respiratory tract congestion | 23.15 | 10.55 | 60 | 85726 | 19894 | 79638708 |
| Granuloma | 23.14 | 10.55 | 36 | 85750 | 8261 | 79650341 |
| Affective disorder | 23.06 | 10.55 | 36 | 85750 | 8283 | 79650319 |
| C-reactive protein increased | 23.03 | 10.55 | 67 | 85719 | 128960 | 79529642 |
| Genital herpes simplex | 22.31 | 10.55 | 10 | 85776 | 373 | 79658229 |
| Type IIa hyperlipidaemia | 22.23 | 10.55 | 9 | 85777 | 260 | 79658342 |
| Neutropenia | 21.81 | 10.55 | 201 | 85585 | 287509 | 79371093 |
| Sputum purulent | 21.49 | 10.55 | 15 | 85771 | 1334 | 79657268 |
| Eosinophil count increased | 21.48 | 10.55 | 53 | 85733 | 17052 | 79641550 |
| Peripheral swelling | 21.47 | 10.55 | 186 | 85600 | 269431 | 79389171 |
| Dyslipidaemia | 21.37 | 10.55 | 42 | 85744 | 11591 | 79647011 |
| Malignant neoplasm progression | 21.21 | 10.55 | 75 | 85711 | 135915 | 79522687 |
| Palmar-plantar erythrodysaesthesia syndrome | 20.83 | 10.55 | 5 | 85781 | 33129 | 79625473 |
| Injection site bruising | 20.81 | 10.55 | 9 | 85777 | 40993 | 79617609 |
| Hypoaesthesia | 20.61 | 10.55 | 111 | 85675 | 179241 | 79479361 |
| Drug ineffective for unapproved indication | 20.61 | 10.55 | 15 | 85771 | 51223 | 79607379 |
| Sepsis | 20.41 | 10.55 | 405 | 85381 | 269023 | 79389579 |
| Inflammation | 20.38 | 10.55 | 44 | 85742 | 93709 | 79564893 |
| Myelosuppression | 20.21 | 10.55 | 9 | 85777 | 40287 | 79618315 |
| Adverse event | 20.13 | 10.55 | 21 | 85765 | 60193 | 79598409 |
| Osteopenia | 20.06 | 10.55 | 54 | 85732 | 18310 | 79640292 |
| Decreased appetite | 20.02 | 10.55 | 254 | 85532 | 342164 | 79316438 |
| Blood pH decreased | 19.97 | 10.55 | 25 | 85761 | 4686 | 79653916 |
| Eye disorder | 19.96 | 10.55 | 63 | 85723 | 23349 | 79635253 |
| Hepatic function abnormal | 19.75 | 10.55 | 30 | 85756 | 73077 | 79585525 |
| Dust allergy | 19.74 | 10.55 | 15 | 85771 | 1521 | 79657081 |
| Blood calcium increased | 19.66 | 10.55 | 38 | 85748 | 10362 | 79648240 |
| Use of accessory respiratory muscles | 19.27 | 10.55 | 10 | 85776 | 517 | 79658085 |
| Cytomegalovirus infection | 19.17 | 10.55 | 11 | 85775 | 42633 | 79615969 |
| Iron deficiency | 19.01 | 10.55 | 38 | 85748 | 10616 | 79647986 |
| Obstruction | 18.80 | 10.55 | 24 | 85762 | 4586 | 79654016 |
| Bronchospasm paradoxical | 18.70 | 10.55 | 7 | 85779 | 163 | 79658439 |
| Injection site pain | 18.69 | 10.55 | 74 | 85712 | 129764 | 79528838 |
| Colitis ischaemic | 18.66 | 10.55 | 47 | 85739 | 15312 | 79643290 |
| Musculoskeletal stiffness | 18.66 | 10.55 | 111 | 85675 | 174897 | 79483705 |
| Humidity intolerance | 18.65 | 10.55 | 9 | 85777 | 398 | 79658204 |
| Oral candidiasis | 18.56 | 10.55 | 72 | 85714 | 29556 | 79629046 |
| Injection site erythema | 18.44 | 10.55 | 35 | 85751 | 78162 | 79580440 |
| Cor pulmonale | 18.44 | 10.55 | 17 | 85769 | 2251 | 79656351 |
| Injection site reaction | 18.44 | 10.55 | 19 | 85767 | 54766 | 79603836 |
| Ischaemic cardiomyopathy | 18.21 | 10.55 | 31 | 85755 | 7664 | 79650938 |
| Suicidal ideation | 18.15 | 10.55 | 34 | 85752 | 76306 | 79582296 |
| Bundle branch block left | 18.13 | 10.55 | 39 | 85747 | 11474 | 79647128 |
| Rhinorrhoea | 18.11 | 10.55 | 142 | 85644 | 75932 | 79582670 |
| Hypohidrosis | 18.08 | 10.55 | 8 | 85778 | 289 | 79658313 |
| Forced vital capacity decreased | 18.07 | 10.55 | 15 | 85771 | 1728 | 79656874 |
| Mobility decreased | 17.99 | 10.55 | 69 | 85717 | 122106 | 79536496 |
| Peak expiratory flow rate abnormal | 17.89 | 10.55 | 6 | 85780 | 100 | 79658502 |
| Stomatitis | 17.89 | 10.55 | 89 | 85697 | 146668 | 79511934 |
| Heparin-induced thrombocytopenia | 17.84 | 10.55 | 35 | 85751 | 9647 | 79648955 |
| Pneumonia staphylococcal | 17.75 | 10.55 | 24 | 85762 | 4850 | 79653752 |
| Basal cell carcinoma | 17.74 | 10.55 | 9 | 85777 | 37366 | 79621236 |
| Pancytopenia | 17.73 | 10.55 | 105 | 85681 | 165640 | 79492962 |
| Subcutaneous emphysema | 17.69 | 10.55 | 15 | 85771 | 1779 | 79656823 |
| Sopor | 17.15 | 10.55 | 7 | 85779 | 33003 | 79625599 |
| Rectal prolapse | 17.08 | 10.55 | 16 | 85770 | 2162 | 79656440 |
| Knee arthroplasty | 16.96 | 10.55 | 13 | 85773 | 43235 | 79615367 |
| Viral myelitis | 16.92 | 10.55 | 6 | 85780 | 119 | 79658483 |
| Bilirubin conjugated abnormal | 16.88 | 10.55 | 6 | 85780 | 120 | 79658482 |
| Long QT syndrome | 16.83 | 10.55 | 26 | 85760 | 5929 | 79652673 |
| Myocardial infarction | 16.81 | 10.55 | 285 | 85501 | 183844 | 79474758 |
| Appetite disorder | 16.79 | 10.55 | 30 | 85756 | 7709 | 79650893 |
| Depressive symptom | 16.71 | 10.55 | 27 | 85759 | 6396 | 79652206 |
| Carbon dioxide increased | 16.70 | 10.55 | 16 | 85770 | 2224 | 79656378 |
| Tachycardia | 16.54 | 10.55 | 276 | 85510 | 177492 | 79481110 |
| Total lung capacity abnormal | 16.47 | 10.55 | 7 | 85779 | 229 | 79658373 |
| Chest X-ray abnormal | 16.39 | 10.55 | 30 | 85756 | 7853 | 79650749 |
| Sedation | 16.36 | 10.55 | 19 | 85767 | 51876 | 79606726 |
| Tracheomalacia | 16.32 | 10.55 | 8 | 85778 | 366 | 79658236 |
| Dystrophic calcification | 16.30 | 10.55 | 6 | 85780 | 133 | 79658469 |
| Injection site swelling | 16.26 | 10.55 | 16 | 85770 | 47116 | 79611486 |
| Bronchial wall thickening | 16.26 | 10.55 | 17 | 85769 | 2624 | 79655978 |
| Generalised tonic-clonic seizure | 16.22 | 10.55 | 14 | 85772 | 43896 | 79614706 |
| Multimorbidity | 16.21 | 10.55 | 13 | 85773 | 1426 | 79657176 |
| Brain hypoxia | 16.03 | 10.55 | 11 | 85775 | 952 | 79657650 |
| Eosinophil count abnormal | 15.97 | 10.55 | 10 | 85776 | 741 | 79657861 |
| Dry eye | 15.94 | 10.55 | 10 | 85776 | 36921 | 79621681 |
| Sinusitis | 15.86 | 10.55 | 297 | 85489 | 195204 | 79463398 |
| Malaise | 15.86 | 10.55 | 661 | 85125 | 489208 | 79169394 |
| Premature delivery | 15.86 | 10.55 | 3 | 85783 | 23464 | 79635138 |
| Frequent bowel movements | 15.78 | 10.55 | 6 | 85780 | 29533 | 79629069 |
| Upper respiratory tract irritation | 15.74 | 10.55 | 7 | 85779 | 256 | 79658346 |
| Pneumonia pseudomonal | 15.59 | 10.55 | 25 | 85761 | 5886 | 79652716 |
| Arthritis | 15.58 | 10.55 | 67 | 85719 | 114813 | 79543789 |
| Occupational exposure to air contaminants | 15.34 | 10.55 | 6 | 85780 | 158 | 79658444 |
| Nausea | 15.18 | 10.55 | 859 | 84927 | 956337 | 78702265 |
| Extrapyramidal disorder | 15.11 | 10.55 | 3 | 85783 | 22676 | 79635926 |
| Drug eruption | 15.05 | 10.55 | 15 | 85771 | 43920 | 79614682 |
| Haematoma | 15.05 | 10.55 | 102 | 85684 | 52093 | 79606509 |
| Throat irritation | 14.93 | 10.55 | 85 | 85701 | 40861 | 79617741 |
| Bone marrow failure | 14.76 | 10.55 | 20 | 85766 | 51087 | 79607515 |
| Eye pruritus | 14.56 | 10.55 | 52 | 85734 | 20518 | 79638084 |
| Pupillary reflex impaired | 14.54 | 10.55 | 18 | 85768 | 3335 | 79655267 |
| Lactic acidosis | 14.43 | 10.55 | 127 | 85659 | 70232 | 79588370 |
| Toxic optic neuropathy | 14.25 | 10.55 | 11 | 85775 | 1142 | 79657460 |
| Abortion spontaneous | 14.16 | 10.55 | 7 | 85779 | 29500 | 79629102 |
| Dysgeusia | 14.01 | 10.55 | 25 | 85761 | 57152 | 79601450 |
| Oral herpes | 13.98 | 10.55 | 6 | 85780 | 27448 | 79631154 |
| Type 2 diabetes mellitus | 13.81 | 10.55 | 107 | 85679 | 57015 | 79601587 |
| Loss of consciousness | 13.74 | 10.55 | 115 | 85671 | 167828 | 79490774 |
| Liver injury | 13.65 | 10.55 | 25 | 85761 | 56589 | 79602013 |
| Inappropriate schedule of product administration | 13.59 | 10.55 | 86 | 85700 | 133542 | 79525060 |
| Supraventricular tachycardia | 13.57 | 10.55 | 52 | 85734 | 21218 | 79637384 |
| Illness | 13.48 | 10.55 | 91 | 85695 | 46420 | 79612182 |
| Chest pain | 13.38 | 10.55 | 398 | 85388 | 281906 | 79376696 |
| Pneumothorax | 13.24 | 10.55 | 63 | 85723 | 28260 | 79630342 |
| Pneumonia respiratory syncytial viral | 13.15 | 10.55 | 13 | 85773 | 1877 | 79656725 |
| Photophobia | 13.10 | 10.55 | 3 | 85783 | 20525 | 79638077 |
| Myalgia | 13.08 | 10.55 | 132 | 85654 | 185509 | 79473093 |
| Vascular parkinsonism | 13.06 | 10.55 | 5 | 85781 | 124 | 79658478 |
| Neuromyelitis optica spectrum disorder | 13.01 | 10.55 | 10 | 85776 | 1032 | 79657570 |
| Pulmonary embolism | 12.98 | 10.55 | 258 | 85528 | 171396 | 79487206 |
| Cytopenia | 12.96 | 10.55 | 3 | 85783 | 20380 | 79638222 |
| Underdose | 12.95 | 10.55 | 10 | 85776 | 33141 | 79625461 |
| Chronic sinusitis | 12.94 | 10.55 | 37 | 85749 | 12989 | 79645613 |
| Colitis ulcerative | 12.92 | 10.55 | 11 | 85775 | 34731 | 79623871 |
| Tracheitis | 12.88 | 10.55 | 11 | 85775 | 1317 | 79657285 |
| Injection site pruritus | 12.77 | 10.55 | 16 | 85770 | 42267 | 79616335 |
| Bursitis | 12.56 | 10.55 | 12 | 85774 | 35832 | 79622770 |
| Forced expiratory volume increased | 12.44 | 10.55 | 4 | 85782 | 58 | 79658544 |
| Grip strength decreased | 12.44 | 10.55 | 4 | 85782 | 21865 | 79636737 |
| Respiratory alkalosis | 12.43 | 10.55 | 19 | 85767 | 4292 | 79654310 |
| Haemophagocytic lymphohistiocytosis | 12.41 | 10.55 | 4 | 85782 | 21833 | 79636769 |
| Intentional self-injury | 12.39 | 10.55 | 10 | 85776 | 32409 | 79626193 |
| Stress cardiomyopathy | 12.36 | 10.55 | 33 | 85753 | 11133 | 79647469 |
| Leukopenia | 12.36 | 10.55 | 74 | 85712 | 116439 | 79542163 |
| Infantile haemangioma | 12.32 | 10.55 | 3 | 85783 | 14 | 79658588 |
| Drug hypersensitivity | 12.29 | 10.55 | 237 | 85549 | 298679 | 79359923 |
| Mucosal inflammation | 12.25 | 10.55 | 41 | 85745 | 75539 | 79583063 |
| Skin lesion | 12.20 | 10.55 | 82 | 85704 | 41762 | 79616840 |
| Infective exacerbation of chronic obstructive airways disease | 12.16 | 10.55 | 15 | 85771 | 2769 | 79655833 |
| Tongue exfoliation | 12.14 | 10.55 | 5 | 85781 | 151 | 79658451 |
| Pneumonia haemophilus | 11.97 | 10.55 | 10 | 85776 | 1162 | 79657440 |
| Bronchitis viral | 11.89 | 10.55 | 10 | 85776 | 1173 | 79657429 |
| Amaurosis | 11.83 | 10.55 | 10 | 85776 | 1181 | 79657421 |
| Coronary artery disease | 11.83 | 10.55 | 115 | 85671 | 65359 | 79593243 |
| Joint stiffness | 11.77 | 10.55 | 16 | 85770 | 40814 | 79617788 |
| Schizophrenia | 11.77 | 10.55 | 40 | 85746 | 15400 | 79643202 |
| Metastases to liver | 11.77 | 10.55 | 8 | 85778 | 28306 | 79630296 |
| Paraesthesia | 11.76 | 10.55 | 127 | 85659 | 176196 | 79482406 |
| Vital capacity decreased | 11.74 | 10.55 | 12 | 85774 | 1804 | 79656798 |
| Nephrocalcinosis | 11.72 | 10.55 | 11 | 85775 | 1491 | 79657111 |
| Product use in unapproved indication | 11.72 | 10.55 | 194 | 85592 | 250165 | 79408437 |
| Interstitial lung disease | 11.69 | 10.55 | 72 | 85714 | 112528 | 79546074 |
| Glycosylated haemoglobin decreased | 11.64 | 10.55 | 8 | 85778 | 694 | 79657908 |
| Cardiac disorder | 11.63 | 10.55 | 115 | 85671 | 65642 | 79592960 |
| Hyperlipidaemia | 11.45 | 10.55 | 57 | 85729 | 26036 | 79632566 |
| Neutrophil count decreased | 11.44 | 10.55 | 57 | 85729 | 93902 | 79564700 |
| Tracheal disorder | 11.39 | 10.55 | 7 | 85779 | 502 | 79658100 |
| Oropharyngeal pain | 11.38 | 10.55 | 173 | 85613 | 109180 | 79549422 |
| Pleural thickening | 11.35 | 10.55 | 15 | 85771 | 2967 | 79655635 |
| Diastolic hypotension | 11.34 | 10.55 | 5 | 85781 | 179 | 79658423 |
| Idiopathic pulmonary fibrosis | 11.31 | 10.55 | 18 | 85768 | 4210 | 79654392 |
| Hyperlactacidaemia | 11.26 | 10.55 | 21 | 85765 | 5574 | 79653028 |
| Pharyngeal mass | 11.18 | 10.55 | 6 | 85780 | 332 | 79658270 |
| Blood bicarbonate decreased | 11.10 | 10.55 | 20 | 85766 | 5171 | 79653431 |
| Injection related reaction | 10.91 | 10.55 | 9 | 85777 | 1027 | 79657575 |
| Expiratory reserve volume decreased | 10.85 | 10.55 | 4 | 85782 | 89 | 79658513 |
| Tumour hyperprogression | 10.80 | 10.55 | 5 | 85781 | 201 | 79658401 |
| Myelodysplastic syndrome | 10.78 | 10.55 | 10 | 85776 | 30291 | 79628311 |
| Serotonin syndrome | 10.75 | 10.55 | 20 | 85766 | 45007 | 79613595 |
| Oesophageal motility disorder | 10.68 | 10.55 | 7 | 85779 | 561 | 79658041 |
| Dry mouth | 10.66 | 10.55 | 143 | 85643 | 87876 | 79570726 |
| Pancreatitis | 10.57 | 10.55 | 38 | 85748 | 68537 | 79590065 |
| Hyperglycaemia | 10.56 | 10.55 | 119 | 85667 | 70216 | 79588386 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | R01AX03 | RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Other nasal preparations |
| ATC | R03AL01 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids |
| ATC | R03AL02 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids |
| ATC | R03BB01 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS Anticholinergics |
| FDA MoA | N0000175370 | Cholinergic Antagonists |
| FDA EPC | N0000175574 | Anticholinergic |
| MeSH PA | D018927 | Anti-Asthmatic Agents |
| MeSH PA | D001993 | Bronchodilator Agents |
| MeSH PA | D018678 | Cholinergic Agents |
| MeSH PA | D018680 | Cholinergic Antagonists |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D019141 | Respiratory System Agents |
| CHEBI has role | CHEBI:35523 | bronchodilator |
| CHEBI has role | CHEBI:48876 | muscarinic antagonists |
| CHEBI has role | CHEBI:53784 | antispasmodics |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Bronchospasm | indication | 4386001 | |
| Chronic obstructive lung disease | indication | 13645005 | DOID:3083 |
| Bronchitis | indication | 32398004 | DOID:6132 |
| Allergic rhinitis | indication | 61582004 | |
| Nasal discharge | indication | 64531003 | |
| Pulmonary emphysema | indication | 87433001 | |
| Chronic Obstructive Pulmonary Disease with Bronchospasms | indication | ||
| Asthma | off-label use | 195967001 | DOID:2841 |
| Asthma-chronic obstructive pulmonary disease overlap syndrome | off-label use | 10692761000119107 | |
| Ocular hypertension | contraindication | 4210003 | DOID:9282 |
| Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Hypokalemia | contraindication | 43339004 | |
| Conduction disorder of the heart | contraindication | 44808001 | |
| Ketoacidosis | contraindication | 56051008 | |
| Metabolic acidosis | contraindication | 59455009 | |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Paradoxical bronchospasm | contraindication | 102578005 | |
| Prolonged QT interval | contraindication | 111975006 | |
| Seizure disorder | contraindication | 128613002 | |
| Bladder outflow obstruction | contraindication | 236645006 | |
| Benign prostatic hyperplasia | contraindication | 266569009 | |
| Retention of urine | contraindication | 267064002 | |
| Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
| Chronic myocardial ischemia | contraindication | 413844008 | DOID:3393 |
| Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
| Congenital long QT syndrome | contraindication | 442917000 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 13.24 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M3 | GPCR | ANTAGONIST | Ki | 9.29 | WOMBAT-PK | CHEMBL | |||
| Muscarinic acetylcholine receptor M2 | GPCR | Ki | 8.82 | WOMBAT-PK | |||||
| Muscarinic acetylcholine receptor M4 | GPCR | Ki | 9.18 | WOMBAT-PK | |||||
| Muscarinic acetylcholine receptor M5 | GPCR | Ki | 8.77 | WOMBAT-PK | |||||
| Muscarinic acetylcholine receptor M1 | GPCR | Ki | 9.31 | WOMBAT-PK | |||||
| Solute carrier family 22 member 2 | Transporter | IC50 | 4.82 | WOMBAT-PK | |||||
| Muscarinic acetylcholine receptor M2 | GPCR | Ki | 9.11 | CHEMBL | |||||
| Muscarinic acetylcholine receptor M1 | GPCR | Ki | 9.54 | CHEMBL | |||||
| Muscarinic acetylcholine receptor M3 | GPCR | Ki | 9.74 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4019791 | VUID |
| N0000147880 | NUI |
| D02212 | KEGG_DRUG |
| 66985-17-9 | SECONDARY_CAS_RN |
| 4019341 | VANDF |
| 4019791 | VANDF |
| C0027235 | UMLSCUI |
| CHEBI:5956 | CHEBI |
| X8M | PDB_CHEM_ID |
| CHEMBL1621597 | ChEMBL_ID |
| DB00332 | DRUGBANK_ID |
| CHEMBL1464005 | ChEMBL_ID |
| CHEMBL2134724 | ChEMBL_ID |
| D009241 | MESH_DESCRIPTOR_UI |
| 3746 | PUBCHEM_CID |
| 325 | IUPHAR_LIGAND_ID |
| GR88G0I6UL | UNII |
| 1309404 | RXNORM |
| 4916 | MMSL |
| 6256 | MMSL |
| d00265 | MMSL |
| 001750 | NDDF |
| 004943 | NDDF |
| 108624006 | SNOMEDCT_US |
| 372518007 | SNOMEDCT_US |
| 386881005 | SNOMEDCT_US |
| 725862005 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Ipratropium Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0045 | SPRAY | 21 ug | NASAL | ANDA | 3 sections |
| Ipratropium Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0045 | SPRAY | 21 ug | NASAL | ANDA | 3 sections |
| Ipratropium Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0046 | SPRAY | 42 ug | NASAL | ANDA | 16 sections |
| Ipratropium Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0046 | SPRAY | 42 ug | NASAL | ANDA | 16 sections |
| Ipratropium Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-7970 | SOLUTION | 0.50 mg | RESPIRATORY (INHALATION) | ANDA | 22 sections |
| Ipratropium Bromide and Albuterol Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-9671 | SOLUTION | 0.50 mg | RESPIRATORY (INHALATION) | ANDA | 28 sections |
| Ipratropium Bromide and Albuterol Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0487-0201 | SOLUTION | 0.50 mg | RESPIRATORY (INHALATION) | ANDA | 28 sections |
| Ipratropium Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0487-9801 | SOLUTION | 0.50 mg | RESPIRATORY (INHALATION) | ANDA | 22 sections |
| Ipratropium Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-3798 | SOLUTION | 0.50 mg | RESPIRATORY (INHALATION) | ANDA | 20 sections |
| Combivent Respimat | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0597-0024 | SPRAY, METERED | 20 ug | RESPIRATORY (INHALATION) | NDA | 27 sections |
| Combivent Respimat | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0597-0024 | SPRAY, METERED | 20 ug | RESPIRATORY (INHALATION) | NDA | 27 sections |
| Atrovent HFA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0087 | AEROSOL, METERED | 17 ug | RESPIRATORY (INHALATION) | NDA | 29 sections |
| Atrovent HFA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0087 | AEROSOL, METERED | 17 ug | RESPIRATORY (INHALATION) | NDA | 29 sections |
| Ipratropium Bromide and Albuterol Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0781-7146 | SOLUTION | 0.50 mg | RESPIRATORY (INHALATION) | ANDA | 28 sections |
| Ipratropium Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-7157 | SOLUTION | 0.50 mg | RESPIRATORY (INHALATION) | ANDA | 23 sections |
| Ipratropium Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-526 | SPRAY, METERED | 21 ug | NASAL | ANDA | 24 sections |
| Ipratropium Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-527 | SPRAY, METERED | 42 ug | NASAL | ANDA | 25 sections |
| Ipratropium Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-911 | SOLUTION | 0.50 mg | RESPIRATORY (INHALATION) | ANDA | 21 sections |
| Ipratropium bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24208-398 | SPRAY, METERED | 21 ug | NASAL | ANDA | 27 sections |
| Ipratropium bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24208-398 | SPRAY, METERED | 21 ug | NASAL | ANDA | 27 sections |
| Ipratropium Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24208-399 | SPRAY, METERED | 42 ug | NASAL | ANDA | 25 sections |
| Ipratropium Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24208-399 | SPRAY, METERED | 42 ug | NASAL | ANDA | 25 sections |
| Ipratropium Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42254-041 | SOLUTION | 0.50 mg | RESPIRATORY (INHALATION) | ANDA | 19 sections |
| Ipratropium Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42254-355 | SPRAY, METERED | 42 ug | NASAL | ANDA | 25 sections |
| Ipratropium Bromide | Human Prescription Drug Label | 1 | 47335-706 | SOLUTION | 0.50 mg | RESPIRATORY (INHALATION) | ANDA | 19 sections |
| Ipratropium Bromide | Human Prescription Drug Label | 1 | 47335-706 | SOLUTION | 0.50 mg | RESPIRATORY (INHALATION) | ANDA | 19 sections |
| Ipratropium Bromide and Albuterol Sulfate | Human Prescription Drug Label | 2 | 47335-756 | SOLUTION | 0.50 mg | RESPIRATORY (INHALATION) | ANDA | 22 sections |
| Ipratropium Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-0668 | SOLUTION | 0.50 mg | RESPIRATORY (INHALATION) | ANDA | 21 sections |
| Ipratropium Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-0668 | SOLUTION | 0.50 mg | RESPIRATORY (INHALATION) | ANDA | 21 sections |
| AtroventHFA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-0961 | AEROSOL, METERED | 17 ug | RESPIRATORY (INHALATION) | NDA | 25 sections |