iotrolan 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
iodine-containing contrast media 1470 79770-24-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • iotrolan
  • iotrol
  • iotrovist
  • isovist
nonionic, isotonic contrast medium designed for intrathecal use; RN given refers to cpd without isomeric designation; DL-3-117 refers to stereoisomer; structure given in first source
  • Molecular weight: 1626.24
  • Formula: C37H48I6N6O18
  • CLOGP: -4.20
  • LIPINSKI: 3
  • HAC: 24
  • HDO: 16
  • TPSA: 399.78
  • ALOGS: -3.48
  • ROTB: 24

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.23 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.49 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 1 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.03 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
None FDA BAYER HLTHCARE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC V08AB06 VARIOUS
CONTRAST MEDIA
X-RAY CONTRAST MEDIA, IODINATED
Watersoluble, nephrotropic, low osmolar X-ray contrast media
MeSH PA D003287 Contrast Media
MeSH PA D064907 Diagnostic Uses of Chemicals

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.81 acidic
pKa2 10.19 acidic
pKa3 10.62 acidic
pKa4 10.97 acidic
pKa5 11.4 acidic
pKa6 13.25 acidic
pKa7 13.67 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4019577 VUID
N0000171578 NUI
D01714 KEGG_DRUG
4019577 VANDF
C0123865 UMLSCUI
CHEBI:31715 CHEBI
CHEMBL1200555 ChEMBL_ID
DB09487 DRUGBANK_ID
C033300 MESH_SUPPLEMENTAL_RECORD_UI
5179 INN_ID
16FL47B687 UNII
3738 PUBCHEM_CID
51474 RXNORM
005146 NDDF
353919004 SNOMEDCT_US
395758008 SNOMEDCT_US

Pharmaceutical products:

None