iopanoic acid Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
iodine-containing contrast media 1465 96-83-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • iopanoic acid
  • iopanoicum
  • iodopanoic acid
  • iodopanic acid
Radiopaque medium used as diagnostic aid.
  • Molecular weight: 570.94
  • Formula: C11H12I3NO2
  • CLOGP: 4.70
  • LIPINSKI: 1
  • HAC: 3
  • HDO: 2
  • TPSA: 63.32
  • ALOGS: -4.62
  • ROTB: 4

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 4 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.02 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 33 % Benet LZ, Broccatelli F, Oprea TI

Approvals:

DateAgencyCompanyOrphan
July 16, 1951 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC V08AC06 VARIOUS
CONTRAST MEDIA
X-RAY CONTRAST MEDIA, IODINATED
Watersoluble, hepatotropic X-ray contrast media
MeSH PA D003287 Contrast Media
MeSH PA D064907 Diagnostic Uses of Chemicals

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Diagnostic aid indication 2949005
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Kidney disease contraindication 90708001 DOID:557
Hb SS disease contraindication 127040003 DOID:10923
Asthma contraindication 195967001 DOID:2841
Pregnancy, function contraindication 289908002
Pheochromocytoma contraindication 302835009
Hypertensive Emergencies contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.84 acidic
pKa2 2.32 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018259 VUID
N0000146589 NUI
D01014 KEGG_DRUG
4018259 VANDF
C0022028 UMLSCUI
CHEBI:5951 CHEBI
CHEMBL867 ChEMBL_ID
D007480 MESH_DESCRIPTOR_UI
DB08946 DRUGBANK_ID
3 INN_ID
FE9794P71J UNII
3735 PUBCHEM_CID
5967 RXNORM
4906 MMSL
d01438 MMSL
001220 NDDF
412227008 SNOMEDCT_US
76155001 SNOMEDCT_US

Pharmaceutical products:

None